KCNMB3 Gene
protein-coding GIFtS: 56
GCID: GC03M178957
|
|
potassium large conductance calcium-activated channel, subfamily...
(Previous symbols: KCNMB2, KCNMBL)
| |
Aliases
for KCNMB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Potassium Large Conductance Calcium-Activated Channel, Subfamily M BetaMember 31 2 | | HBETA32 | | KCNMB21 2 3 | | SLOBETA32 | | KCNMBL1 2 3 | | Calcium-Activated Potassium Channel Subunit Beta-32 | | Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-32 3 | | Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K Beta 3Subunit2 | | Charybdotoxin Receptor Subunit Beta-32 3 | | Slo-Beta-31 | | Maxi K Channel Subunit Beta-32 3 | | BKbeta33 | | K(VCA)Beta-31 | | Hbeta33 | | BK Channel Subunit Beta-32 3 | | Slo-Beta-31 | | BKBETA32 | | |
| External Ids: | HGNC: 62871 | Entrez Gene: 270942 | Ensembl: ENSG000001711217 | OMIM: 6052225 | UniProtKB: Q9NPA13 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408156 | |
Export aliases for KCNMB3 gene to outside databasesPrevious GC identifers: GC03M175611 GC03M179800 GC03M180359 GC03M180278 GC03M180281 GC03M180440 GC03M176360
Summaries
for KCNMB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNMB3:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to thecontrol of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-formingalpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which maypartially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicingresults in multiple transcript variants. A related pseudogene has been identified on chromosome 22. (provided byRefSeq, Jul 2009)
UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calciumsensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functionalproperties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate thecurrent of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only atlarge depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunitsof KCNMB3 are required to block the KCNMA1 tetramer
 summary
for KCNMB3:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNMB3
|
Genomic Views
for KCNMB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNMB3 gene promoter:
RORalpha1 RelA CUTL1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNMB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.3-q27 Ensembl cytogenetic band: 3q26.32 HGNC cytogenetic band: 3q26.3-q27KCNMB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M178957: view genomic region
(about GC identifiers)
Start:
|
178,957,530 bp from pter |
End:
|
178,984,838 bp from pter |
Size:
|
27,309 bases |
Orientation:
|
minus strand |
|
Proteins
for KCNMB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1 (See
protein sequence)Recommended Name: Calcium-activated potassium channel subunit beta-3 Size: 279 amino acids; 31604 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B7Z9C9 D3DNR2 E9PER5 Q9NPG7 Q9NRM9 Q9UHN3Alternative splicing: 5 isoforms: Q9NPA1-1 Q9NPA1-2 Q9NPA1-3 Q9NPA1-4 Q9NPA1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCNMB3: NX_Q9NPA1
Post-translational modifications:
N-glycosylated1
The extracellular domain contains disulfide bond essential for the gating mechanism1
View neXtProt modification sites for NX_Q9NPA1
KCNMB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001157149.1 NP_055222.3 NP_741979.1 NP_741980.1 NP_741981.1
ENSEMBL proteins: ENSP00000417091 ENSP00000376452 ENSP00000376451 ENSP00000327866 ENSP00000319370 ENSP00000418536 Reactome Protein details: Q9NPA1
Human Recombinant Protein Products for KCNMB3:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KCNMB3 for ontologies About GeneDecksing
KCNMB3 Antibody Products:
Assay Products for KCNMB3: |
Protein
Domains /
Families
for KCNMB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNMB3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NPA1ProtoNet protein and cluster: Q9NPA1 2 Blocks protein families: IPB003930 Calcium-activated BK potassium channel beta subunit signature IPB008162 Inorganic pyrophosphatase
UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1Domain: Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by bindingto a receptor siteDomain: The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can berapidly diminished upon cellular repolarizationSimilarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily |
Function
for KCNMB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCMB3_HUMAN, Q9NPA1Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calciumsensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functionalproperties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate thecurrent of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only atlarge depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunitsof KCNMB3 are required to block the KCNMA1 tetramer Genatlas biochemistry entry for KCNMB3:potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control ofsmooth muscle tone and neuronal excitability, modulatory beta member 3,predominantly expressed in pancreas,situated inthe duplication region dup(Bq),see KCNMA1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KCNMB3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for KCNMB3:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for KCNMB3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNMB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB3 |
|
Pathways & Interactions
for KCNMB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nitric oxide stimulates guanylate cyclase | | | 2 | Potassium Channels | | | 3 | Ca2+ activated K+ channels | | | 4 | Transmission across Chemical Synapses | | | 5 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for KCNMB3 (see all 7)
1 
Kegg Pathway (Kegg details for KCNMB3):
KCNMB3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for KCNMB3 (ENSP000003193704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
KCNMB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNMB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for KCNMB3 available from Tocris Bioscience About this table
2 HMDB Compounds for KCNMB3 About this table
1 DrugBank Compound for KCNMB3 About this table
Search CenterWatch for drugs/clinical trials and news about KCNMB3 / KCMB3
|
Transcripts
for KCNMB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNMB3 gene (5 alternative transcripts): NM_001163677.1 NM_014407.3 NM_171828.1 NM_171829.2 NM_171830.1 Unigene Cluster for KCNMB3: Potassium large conductance calcium-activated channel, subfamily M beta member 3 Hs.591285 [show with all ESTs]Unigene Representative Sequence: NR_0281357 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486944 ENST00000497599(uc011bqc.1) ENST00000392686(uc003fjl.3 uc003fjo.3)
ENST00000392685(uc003fjm.3 uc003fjn.3) ENST00000349697(uc003fjp.1)
ENST00000314235 ENST00000485523
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for KCNMB3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNMB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB3 |
Additional cDNA sequence: AF139471.1 AF160968.1 AF170916.1 AF214561.1 AK304837.1 BC082272.1 BC113851.1 NR_028135.1 7 DOTS entries: DT.92416406 DT.95319032 DT.99950166 DT.102836106 DT.120858776 DT.120663210 DT.86853337 24/31 AceView cDNA sequences (see all 31): NM_014407 NM_171830 AI823768 NM_171829 NM_171828 BC082272 AA761761 AW297141 AI816873 CD625664 CD625660 CD625656 AA934876 AF214561 BF027384 CD625662 BM745010 CD625652 AF139471 CD625666 AF170916 AF160968 BX113095 AA917510
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for KCNMB3
|
Expression
for KCNMB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNMB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCNMB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNMB3
SOURCE GeneReport for Unigene cluster: Hs.591285
UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1Tissue specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas,kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis
SABiosciences Custom PCR Arrays for KCNMB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNMB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KCNMB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNMB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNMB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB3 |
Orthologs
for KCNMB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KCNMB3 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.162492 |
Transcribed sequence with weak similarity to protein more |
75.51(n) |
|
BX716835.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CT027646.16 |
-- |
30(a) |
1 ↔ 1 |
2(7616432-7629401) |
ENSEMBL Gene Tree for KCNMB3 (if available)
TreeFam Gene Tree for KCNMB3 (if available) |
Paralogs
for KCNMB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNMB3 gene
- KCNMB22 KCNMB42 KCNMB12
3 SIMAP similar genes for KCNMB3 using alignment to 2 protein entries: KCMB3_HUMAN (see all proteins):KCNMB2 KCNMB4 KCNMB1
KCNMB3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KCNMB3
PGOHUM00000259680
|
Genomic Variants
for KCNMB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNMB3 (178957530 - 178984838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNMB3: --
Human Gene Mutation Database (HGMD): KCNMB3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNMB3 |
|
Disorders
/ Diseases
for KCNMB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNMB3 for disorders About GeneDecksing
OMIM gene information: 605222
OMIM disorders: --
3  diseases for KCNMB3: About MalaCardsidiopathic generalized epilepsy generalized epilepsy neuronitis
1 disease from the University of Copenhagen DISEASES database for KCNMB3:Idiopathic generalized epilepsy Human Genome Epidemiology (HuGE) Navigator: KCNMB3 (1 document)
Export disorders for KCNMB3 gene to outside databases
|
Publications
for KCNMB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNMB3 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with KCNMB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PubMed id 10585773)1, 2, 3 Riazi M.A.... McDermid H.E. (1999)
- Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. (PubMed id 12740608)1, 2 Zeng X.-H.... Lingle C.J. (2003)
- Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation. (PubMed id 14612589)1, 2 Hu S.... Ali D.W. (2003)
- New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
- Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. (PubMed id 11382809)1, 2 Zeng X.-H.... Lingle C.J. (2001)
- Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. (PubMed id 11382808)1, 2 Lingle C.J.... Xia X.-M. (2001)
- hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2 Behrens R....Pongs O. (2000)
- Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. (PubMed id 10864947)1, 2 Xia X.-M.... Lingle C.J. (2000)
- A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
- Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel. (PubMed id 10766764)1, 2 Uebele V.N.... Swanson R. (2000)
|
External Searches for KCNMB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNMB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNMB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNMB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNMB3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNMB3 gene:
Search GeneIP for patents involving KCNMB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNMB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for KCNMB3 | | OriGene shRNA RFP for KCNMB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNMB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNMB3 | | | OriGene Protein Over-expression Lysate for KCNMB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNMB3 | | OriGene 3'-UTR Clone for KCNMB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNMB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNMB3 | | OriGene Custom Protein Services for KCNMB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNMB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNMB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNMB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNMB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNMB3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KCNMB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNMB3 |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013
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