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Aliases for KCNMB3 Gene

Aliases for KCNMB3 Gene

  • Potassium Channel Subfamily M Regulatory Beta Subunit 3 2 3
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta Member 3 2 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-3 3 4
  • Charybdotoxin Receptor Subunit Beta-3 3 4
  • Big Potassium Channel Beta Subunit 3 2 3
  • Maxi K Channel Subunit Beta-3 3 4
  • MaxiK Channel Beta-Subunit 3 2 3
  • BK Channel Beta Subunit 3 2 3
  • BK Channel Subunit Beta-3 3 4
  • K(VCA)BETA-3 3 4
  • SLO-BETA-3 3 4
  • BKBETA3 3 4
  • Hbeta3 3 4
  • KCNMB2 3 4
  • KCNMBL 3 4
  • Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K Beta 3 Subunit 3
  • Calcium-Activated Potassium Channel Regulatory Subunit 3
  • SLOBETA3 3

External Ids for KCNMB3 Gene

Previous HGNC Symbols for KCNMB3 Gene

  • KCNMB2
  • KCNMBL

Previous GeneCards Identifiers for KCNMB3 Gene

  • GC03M175611
  • GC03M179800
  • GC03M180359
  • GC03M180278
  • GC03M180281
  • GC03M180440
  • GC03M178957
  • GC03M176360

Summaries for KCNMB3 Gene

Entrez Gene Summary for KCNMB3 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

GeneCards Summary for KCNMB3 Gene

KCNMB3 (Potassium Channel Subfamily M Regulatory Beta Subunit 3) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot for KCNMB3 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Tocris Summary for KCNMB3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNMB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB3 Gene

Genomics for KCNMB3 Gene

Regulatory Elements for KCNMB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNMB3 Gene

Chromosome:
3
Start:
179,236,691 bp from pter
End:
179,267,050 bp from pter
Size:
30,360 bases
Orientation:
Minus strand

Genomic View for KCNMB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB3 Gene

Proteins for KCNMB3 Gene

  • Protein details for KCNMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA1-KCMB3_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-3
    Protein Accession:
    Q9NPA1
    Secondary Accessions:
    • B7Z9C9
    • D3DNR2
    • E9PER5
    • Q9NPG7
    • Q9NRM9
    • Q9UHN3

    Protein attributes for KCNMB3 Gene

    Size:
    279 amino acids
    Molecular mass:
    31604 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.

    Alternative splice isoforms for KCNMB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNMB3 Gene

Proteomics data for KCNMB3 Gene at MOPED

Post-translational modifications for KCNMB3 Gene

Antibody Products

No data available for DME Specific Peptides for KCNMB3 Gene

Domains & Families for KCNMB3 Gene

Suggested Antigen Peptide Sequences for KCNMB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA1

UniProtKB/Swiss-Prot:

KCMB3_HUMAN :
  • Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
Domain:
  • Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site
  • The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
genes like me logo Genes that share domains with KCNMB3: view

Function for KCNMB3 Gene

Molecular function for KCNMB3 Gene

GENATLAS Biochemistry:
potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability, modulatory beta member 3,predominantly expressed in pancreas,situated in the duplication region dup(Bq),see KCNMA1
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Gene Ontology (GO) - Molecular Function for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding --
GO:0004427 inorganic diphosphatase activity --
GO:0015269 calcium-activated potassium channel activity IDA 10692449
GO:0015459 potassium channel regulator activity NAS 10766764
genes like me logo Genes that share ontologies with KCNMB3: view
genes like me logo Genes that share phenotypes with KCNMB3: view

Animal Model Products

miRNA for KCNMB3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNMB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNMB3 Gene

Localization for KCNMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB3 Gene COMPARTMENTS Subcellular localization image for KCNMB3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10692449
GO:0008076 voltage-gated potassium channel complex IDA 10692449
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNMB3: view

Pathways & Interactions for KCNMB3 Gene

genes like me logo Genes that share pathways with KCNMB3: view

Interacting Proteins for KCNMB3 Gene

Gene Ontology (GO) - Biological Process for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IDA 10692449
GO:0005513 detection of calcium ion IDA 10692449
GO:0006796 phosphate-containing compound metabolic process --
GO:0006813 potassium ion transport IDA 10692449
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with KCNMB3: view

No data available for SIGNOR curated interactions for KCNMB3 Gene

Drugs & Compounds for KCNMB3 Gene

(5) Drugs for KCNMB3 Gene - From: Tocris, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Channel blocker, Target, inhibitor 2912
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 28
Potassium Experimental Pharma 0
Calcium Nutra 0
Flupirtine maleate Pharma KV7 channel activator 0

(3) Additional Compounds for KCNMB3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Kaliotoxin
145199-73-1
L-364,373
103342-82-1
PD 118057
313674-97-4
genes like me logo Genes that share compounds with KCNMB3: view

Transcripts for KCNMB3 Gene

Unigene Clusters for KCNMB3 Gene

Potassium large conductance calcium-activated channel, subfamily M beta member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNMB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3:
SP4: - - -

Relevant External Links for KCNMB3 Gene

GeneLoc Exon Structure for
KCNMB3
ECgene alternative splicing isoforms for
KCNMB3

Expression for KCNMB3 Gene

mRNA expression in normal human tissues for KCNMB3 Gene

SOURCE GeneReport for Unigene cluster for KCNMB3 Gene Hs.591285

mRNA Expression by UniProt/SwissProt for KCNMB3 Gene

Q9NPA1-KCMB3_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
genes like me logo Genes that share expression patterns with KCNMB3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNMB3 Gene

Orthologs for KCNMB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNMB3 35
  • 84.36 (n)
  • 77.98 (a)
KCNMB3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb3 35
  • 75.77 (n)
  • 73.11 (a)
Kcnmb3 16
Kcnmb3 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNMB3 35
  • 99.16 (n)
  • 97.83 (a)
KCNMB3 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb3 35
  • 76.19 (n)
  • 75.63 (a)
dog
(Canis familiaris)
Mammalia KCNMB3 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNMB3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnmb3 35
  • 65.7 (n)
  • 62.81 (a)
Str.16249 35
zebrafish
(Danio rerio)
Actinopterygii KCNMB3 36
  • 31 (a)
OneToOne
Species with no ortholog for KCNMB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNMB3 Gene

ENSEMBL:
Gene Tree for KCNMB3 (if available)
TreeFam:
Gene Tree for KCNMB3 (if available)

Paralogs for KCNMB3 Gene

Paralogs for KCNMB3 Gene

(3) SIMAP similar genes for KCNMB3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KCNMB3 Gene

genes like me logo Genes that share paralogs with KCNMB3: view

Variants for KCNMB3 Gene

Sequence variations from dbSNP and Humsavar for KCNMB3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1055071 -- 179,243,540(-) ATGAA(A/G/T)TTGGT intron-variant
rs1059690 -- 179,243,192(-) GGAAC(C/T)CCCTT intron-variant, reference, synonymous-codon, nc-transcript-variant
rs1059691 -- 179,242,819(-) ACTAA(C/T)AATGT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1170672 - 179,250,872(+) GCACA(C/T)CTAGT reference, missense, nc-transcript-variant
rs1170673 -- 179,252,222(+) cctac(A/G)gtgtc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNMB3 Gene

Variant ID Type Subtype PubMed ID
dgv5352n71 CNV Loss 21882294
nsv829806 CNV Gain 17160897
nsv471116 CNV Gain 18288195

Variation tolerance for KCNMB3 Gene

Residual Variation Intolerance Score: 73.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.57; 96.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNMB3 Gene

HapMap Linkage Disequilibrium report
KCNMB3
Human Gene Mutation Database (HGMD)
KCNMB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNMB3 Gene

Disorders for KCNMB3 Gene

Relevant External Links for KCNMB3

Genetic Association Database (GAD)
KCNMB3
Human Genome Epidemiology (HuGE) Navigator
KCNMB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNMB3
genes like me logo Genes that share disorders with KCNMB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNMB3 Gene

Publications for KCNMB3 Gene

  1. Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. (PMID: 18591419) Zeng X. … Lingle C.J. (J. Gen. Physiol. 2008) 23 67
  2. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PMID: 10585773) Riazi M.A. … McDermid H.E. (Genomics 1999) 2 67
  3. Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. (PMID: 8760033) Hatton C.J. … Peers C. (Am. J. Physiol. 1996) 25 26
  4. High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. (PMID: 1376313) Alvarez J. … Garcia-Sancho J. (J. Biol. Chem. 1992) 25 26
  5. Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance. (PMID: 23826284) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 67

Products for KCNMB3 Gene

Sources for KCNMB3 Gene

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