Aliases for KCNMB3 Gene
- Potassium Channel Subfamily M Regulatory Beta Subunit 3 2 3
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta Member 3 2 3
- Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-3 3 4
- Charybdotoxin Receptor Subunit Beta-3 3 4
- Big Potassium Channel Beta Subunit 3 2 3
- Maxi K Channel Subunit Beta-3 3 4
- MaxiK Channel Beta-Subunit 3 2 3
- BK Channel Beta Subunit 3 2 3
- BK Channel Subunit Beta-3 3 4
- K(VCA)BETA-3 3 4
External Ids for KCNMB3 Gene
Previous Symbols for KCNMB3 Gene
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
GeneCards Summary for KCNMB3 Gene
KCNMB3 (Potassium Channel Subfamily M Regulatory Beta Subunit 3) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB4.
UniProtKB/Swiss-Prot for KCNMB3 Gene
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.