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KCNMB3 Gene

protein-coding   GIFtS: 57
GCID: GC03M178957

Potassium Large Conductance Calcium-Activated Channel, Subfamily...


(Previous symbols: KCNMB2, KCNMBL)
  See KCNMB3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta
Member 31 2
     HBETA32
KCNMB21 2 3     SLOBETA32
KCNMBL1 2 3     Calcium-Activated Potassium Channel Subunit Beta-32
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-32 3     Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K
Beta 3 Subunit2
Charybdotoxin Receptor Subunit Beta-32 3     slo-beta-32
Maxi K Channel Subunit Beta-32 3     BKbeta33
K(VCA)beta-32 3     Hbeta33
BK Channel Subunit Beta-32 3     Slo-beta-33
BKBETA32     

External Ids:    HGNC: 62871   Entrez Gene: 270942   Ensembl: ENSG000001711217   OMIM: 6052225   UniProtKB: Q9NPA13   

Export aliases for KCNMB3 gene to outside databases

Previous GC identifers: GC03M175611 GC03M179800 GC03M180359 GC03M180278 GC03M180281 GC03M180440 GC03M176360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNMB3 Gene:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to
the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the
pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta
subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents.
Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on
chromosome 22. (provided by RefSeq, Jul 2009)

GeneCards Summary for KCNMB3 Gene:
KCNMB3 (potassium large conductance calcium-activated channel, subfamily M beta member 3) is a protein-coding gene. Diseases associated with KCNMB3 include idiopathic generalized epilepsy. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB2.

UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the
functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4
partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1
channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable
inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer

summary for KCNMB3 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNMB3 gene promoter:
         RORalpha1   RelA   CUTL1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNMB3 promoter sequence
   Search Chromatin IP Primers for KCNMB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNMB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3-q27   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.3-q27

KCNMB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M178957:  view genomic region     (about GC identifiers)

Start:
178,957,530 bp from pter      End:
178,984,838 bp from pter
Size:
27,309 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-3  
Size: 279 amino acids; 31604 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer
Secondary accessions: B7Z9C9 D3DNR2 E9PER5 Q9NPG7 Q9NRM9 Q9UHN3
Alternative splicing: 5 isoforms:  Q9NPA1-1   Q9NPA1-2   Q9NPA1-3   Q9NPA1-4   Q9NPA1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNMB3: NX_Q9NPA1

Explore proteomics data for KCNMB3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • The extracellular domain contains disulfide bond essential for the gating mechanism1
  • Glycosylation2 at Asn131

  • See KCNMB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001157149.1  NP_055222.3  NP_741979.1  NP_741980.1  NP_741981.1  

    ENSEMBL proteins: 
     ENSP00000417091   ENSP00000376452   ENSP00000376451   ENSP00000319370   ENSP00000327866  
     ENSP00000418536  
    Reactome Protein details: Q9NPA1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels

    1 InterPro protein domain:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q9NPA1

    ProtoNet protein and cluster: Q9NPA1

    2 Blocks protein domains:
    IPB003930 Calcium-activated BK potassium channel beta subunit signature
    IPB008162 Inorganic pyrophosphatase


    UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
    Domain: Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by
    binding to a receptor site
    Domain: The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can
    be rapidly diminished upon cellular repolarization
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily


    Find genes that share domains with KCNMB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMB3_HUMAN, Q9NPA1
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the
    functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4
    partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1
    channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable
    inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer

         Genatlas biochemistry entry for KCNMB3:
    potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the
    control of smooth muscle tone and neuronal excitability, modulatory beta member 3,predominantly expressed in
    pancreas,situated in the duplication region dup(Bq),see KCNMA1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015269calcium-activated potassium channel activity IDA10692449
    GO:0015459potassium channel regulator activity NAS10766764
         
    Find genes that share ontologies with KCNMB3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNMB3:
     Increased gamma-H2AX phosphory 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCMB3_HUMAN, Q9NPA1: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----

    Find genes that share ontologies with KCNMB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNMB3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    2Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Hemostasis
    Hemostasis0.43
    5Potassium Channels
    Potassium Channels0.43


    Find genes that share SuperPaths with KCNMB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for KCNMB3
        Ca2+ activated K+ channels
    cGMP effects


    2 Kegg Pathways  (Kegg details for KCNMB3):
        Vascular smooth muscle contraction
    Insulin secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNMB3
    Interactions:

        Search GeneGlobe Interaction Network for KCNMB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNMB3 (ENSP000003193704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKG1ENSP000003630924STRING: ENSP00000363092
    PRKXENSP000002628484STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for KCNMB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    2 HMDB Compounds for KCNMB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PotassiumK+ (see all 16)7440-09-7--

    1 DrugBank Compound for KCNMB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNMB3 gene (5 alternative transcripts): 
    NM_001163677.1  NM_014407.3  NM_171828.2  NM_171829.2  NM_171830.1  

    Unigene Cluster for KCNMB3:

    Potassium large conductance calcium-activated channel, subfamily M beta member 3
    Hs.591285  [show with all ESTs]
    Unigene Representative Sequence: NR_028135
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486944 ENST00000497599(uc011bqc.1) ENST00000392686(uc003fjl.3 uc003fjo.3)
    ENST00000392685(uc003fjm.3 uc003fjn.3) ENST00000314235 ENST00000349697(uc003fjp.1)
    ENST00000485523
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    Additional mRNA sequence: 

    AF139471.1 AF160968.1 AF170916.1 AF214561.1 AK304837.1 BC082272.1 BC113851.1 NR_028135.1 

    7 DOTS entries:

    DT.92416406  DT.95319032  DT.99950166  DT.102836106  DT.120858776  DT.120663210  DT.86853337 

    Selected AceView cDNA sequences (see all 31):

    NM_171828 AI823768 BC082272 NM_171830 NM_171829 NM_014407 AF214561 AW297141 
    AA761761 CD625662 CD625660 CD625652 BF027384 AF160968 CD625656 BX113095 
    AA934876 AF139471 AA917510 AF170916 CD625664 AI816873 CD625666 BM745010 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -     -                                 
    SP2:                                                      
    SP3:                                                      
    SP4:        -     -     -                                 


    ECgene alternative splicing isoforms for KCNMB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNMB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNMB3 Expression
    About this image

    KCNMB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNMB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591285

    UniProtKB/Swiss-Prot: KCMB3_HUMAN, Q9NPA1
    Tissue specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta,
    pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnmb31 , 5 potassium large conductance calcium-activated channel, more1, 5 75.77(n)1
    73.11(a)1
      3 (15.73 cM)5
    1005028761  NM_001195074.11  NP_001182003.11 
     324723215 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    many ↔ many
    AAWZ02039013(7499-7971)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.162492 Transcribed sequence with weak similarity to protein more 75.51(n)    BX716835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii KCNMB36
    potassium large conductance calcium-activated chan...
    31(a)
    1 ↔ 1
    2(7616255-7629451) ENSDARG00000063129


    ENSEMBL Gene Tree for KCNMB3 (if available)
    TreeFam Gene Tree for KCNMB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNMB3 gene
    KCNMB22  KCNMB42  KCNMB12  
    3 SIMAP similar genes for KCNMB3 using alignment to 2 protein entries:     KCMB3_HUMAN (see all proteins):
    KCNMB2    KCNMB4    KCNMB1

    Find genes that share paralogs with KCNMB3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KCNMB3
    PGOHUM00000259680


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNMB3 (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925143351,2
    --178957176(+) TTAGAC/GTAAAC 2 -- ds50010--------
    rs1405347351,2
    C--178957209(+) AAATC-/ATTATCTA 2 -- ds50010--------
    rs1846518631,2
    --178957300(+) GAGGTC/TGGAGA 2 -- ds50010--------
    rs1889284361,2
    --178957520(+) AAATTC/TGAACC 2 -- ds50010--------
    rs1813414821,2
    --178957677(+) CAAGAC/TGCATG 2 -- ut31 nc-transcript-variant0--------
    rs40961271,2
    --178957684(-) AGTAAC/TACATG 2 -- ut31 nc-transcript-variant0--------
    rs39146761,2
    --178957688(-) ATATAA/GTAACA 2 -- ut31 nc-transcript-variant0--------
    rs40961261,2
    --178957773(-) GTCACA/GGGCCA 2 -- ut31 nc-transcript-variant0--------
    rs39765071,2
    C,F,A,H--178957783(-) AGTAAG/ATGCAG 2 -- ut31 nc-transcript-variant15Minor allele frequency- A:0.21NA EA NS WA EU 1375
    rs1845505951,2
    C,F--178957810(+) AACTGT/CCAATG 3 /T /A mis11Minor allele frequency- C:0.01EU 569

    HapMap Linkage Disequilibrium report for KCNMB3 (178957530 - 178984838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNMB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5352n71CNV Loss21882294
    nsv471116CNV Gain18288195
    nsv829806CNV Gain17160897

    Human Gene Mutation Database (HGMD): KCNMB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNMB3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605222    OMIM disorders: --

    1 disease for KCNMB3:    
    About MalaCards
    idiopathic generalized epilepsy


    Find genes that share disorders with KCNMB3           About GenesLikeMe

    Genetic Association Database (GAD): KCNMB3
    Human Genome Epidemiology (HuGE) Navigator: KCNMB3 (1 document)

    Export disorders for KCNMB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNMB3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with KCNMB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PubMed id 10585773)1, 2, 3 Riazi M.A.... McDermid H.E. (Genomics 1999)
    2. Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. (PubMed id 16958040)1, 4 Lorenz S....Sander T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    3. Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. (PubMed id 12740608)1, 2 Zeng X.-H.... Lingle C.J. (Nat. Struct. Biol. 2003)
    4. Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation. (PubMed id 14612589)1, 2 Hu S.... Ali D.W. (Physiol. Genomics 2003)
    5. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (News Physiol. Sci. 2002)
    6. Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. (PubMed id 11382809)1, 2 Zeng X.-H.... Lingle C.J. (J. Gen. Physiol. 2001)
    7. Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. (PubMed id 11382808)1, 2 Lingle C.J.... Xia X.-M. (J. Gen. Physiol. 2001)
    8. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. (PubMed id 10828459)1, 2 Behrens R....Pongs O. (FEBS Lett. 2000)
    9. Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. (PubMed id 10864947)1, 2 Xia X.-M.... Lingle C.J. (J. Neurosci. 2000)
    10. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27094 HGNC: 6287 AceView: KCNMB3 Ensembl:ENSG00000171121 euGenes: HUgn27094
    ECgene: KCNMB3 Kegg: 27094 H-InvDB: KCNMB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNMB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNMB3 gene:
    Search GeneIP for patents involving KCNMB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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