Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNMB3 Gene

Aliases for KCNMB3 Gene

  • Potassium Channel Subfamily M Regulatory Beta Subunit 3 2 3
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M Beta Member 3 2 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-3 3 4
  • Charybdotoxin Receptor Subunit Beta-3 3 4
  • Big Potassium Channel Beta Subunit 3 2 3
  • Maxi K Channel Subunit Beta-3 3 4
  • MaxiK Channel Beta-Subunit 3 2 3
  • BK Channel Beta Subunit 3 2 3
  • BK Channel Subunit Beta-3 3 4
  • K(VCA)BETA-3 3 4
  • SLO-BETA-3 3 4
  • BKBETA3 3 4
  • Hbeta3 3 4
  • KCNMB2 3 4
  • KCNMBL 3 4
  • Large Conductance, Voltage And Ca2+ Activated Potassium Channel Maxi K Beta 3 Subunit 3
  • Calcium-Activated Potassium Channel Regulatory Subunit 3
  • Calcium-Activated Potassium Channel Subunit Beta-3 3
  • SLOBETA3 3

External Ids for KCNMB3 Gene

Previous Symbols for KCNMB3 Gene

  • KCNMB2
  • KCNMBL

Summaries for KCNMB3 Gene

Entrez Gene Summary for KCNMB3 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

GeneCards Summary for KCNMB3 Gene

KCNMB3 (Potassium Channel Subfamily M Regulatory Beta Subunit 3) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot for KCNMB3 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Tocris Summary for KCNMB3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB3 Gene

Genomics for KCNMB3 Gene

Genomic Location for KCNMB3 Gene

Start:
179,236,691 bp from pter
End:
179,267,050 bp from pter
Size:
30,360 bases
Orientation:
Minus strand

Genomic View for KCNMB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNMB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB3 Gene

Regulatory Elements for KCNMB3 Gene

Proteins for KCNMB3 Gene

  • Protein details for KCNMB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA1-KCMB3_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-3
    Protein Accession:
    Q9NPA1
    Secondary Accessions:
    • B7Z9C9
    • D3DNR2
    • E9PER5
    • Q9NPG7
    • Q9NRM9
    • Q9UHN3

    Protein attributes for KCNMB3 Gene

    Size:
    279 amino acids
    Molecular mass:
    31604 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.

    Alternative splice isoforms for KCNMB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNMB3 Gene

Proteomics data for KCNMB3 Gene at MOPED

Post-translational modifications for KCNMB3 Gene

Other Protein References for KCNMB3 Gene

No data available for DME Specific Peptides for KCNMB3 Gene

Domains for KCNMB3 Gene

Gene Families for KCNMB3 Gene

HGNC:
  • KCN :Potassium channels

UniProtKB/Swiss-Prot:

KCMB3_HUMAN
Domain:
  • Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site:
    • Q9NPA1
  • The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization:
    • Q9NPA1
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.:
    • Q9NPA1
genes like me logo Genes that share domains with KCNMB3: view

Function for KCNMB3 Gene

Molecular function for KCNMB3 Gene

GENATLAS Biochemistry: potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability, modulatory beta member 3,predominantly expressed in pancreas,situated in the duplication region dup(Bq),see KCNMA1
UniProtKB/Swiss-Prot Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Gene Ontology (GO) - Molecular Function for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015269 calcium-activated potassium channel activity IDA 10692449
GO:0015459 potassium channel regulator activity NAS 10766764
genes like me logo Genes that share ontologies with KCNMB3: view

Phenotypes for KCNMB3 Gene

GenomeRNAi human phenotypes for KCNMB3:
genes like me logo Genes that share phenotypes with KCNMB3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNMB3 Gene

Localization for KCNMB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB3 Gene COMPARTMENTS Subcellular localization image for KCNMB3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10692449
GO:0008076 voltage-gated potassium channel complex IDA 10692449
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNMB3: view

Pathways for KCNMB3 Gene

genes like me logo Genes that share pathways with KCNMB3: view

Pathways by source for KCNMB3 Gene

Interacting Proteins for KCNMB3 Gene

Gene Ontology (GO) - Biological Process for KCNMB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IDA 10692449
GO:0005513 detection of calcium ion IDA 10692449
GO:0006813 potassium ion transport IDA 10692449
GO:0007268 synaptic transmission TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with KCNMB3: view

Compounds for KCNMB3 Gene

(5) Tocris Compounds for KCNMB3 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(2) HMDB Compounds for KCNMB3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Potassium
  • K+
7440-09-7

(1) Drugbank Compounds for KCNMB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miconazole
22916-47-8 target inhibitor
genes like me logo Genes that share compounds with KCNMB3: view

Transcripts for KCNMB3 Gene

Unigene Clusters for KCNMB3 Gene

Potassium large conductance calcium-activated channel, subfamily M beta member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3:
SP4: - - -

Relevant External Links for KCNMB3 Gene

GeneLoc Exon Structure for
KCNMB3
ECgene alternative splicing isoforms for
KCNMB3

Expression for KCNMB3 Gene

mRNA expression in normal human tissues for KCNMB3 Gene

SOURCE GeneReport for Unigene cluster for KCNMB3 Gene Hs.591285

mRNA Expression by UniProt/SwissProt for KCNMB3 Gene

Q9NPA1-KCMB3_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
genes like me logo Genes that share expressions with KCNMB3: view

Orthologs for KCNMB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNMB3 36
  • 99.16 (n)
  • 97.83 (a)
KCNMB3 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNMB3 36
  • 84.36 (n)
  • 77.98 (a)
KCNMB3 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNMB3 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb3 36
  • 75.77 (n)
  • 73.11 (a)
Kcnmb3 16
Kcnmb3 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNMB3 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB3 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb3 36
  • 76.19 (n)
  • 75.63 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnmb3 36
  • 65.7 (n)
  • 62.81 (a)
Str.16249 36
zebrafish
(Danio rerio)
Actinopterygii KCNMB3 37
  • 31 (a)
OneToOne
Species with no ortholog for KCNMB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNMB3 Gene

ENSEMBL:
Gene Tree for KCNMB3 (if available)
TreeFam:
Gene Tree for KCNMB3 (if available)

Paralogs for KCNMB3 Gene

Paralogs for KCNMB3 Gene

Selected SIMAP similar genes for KCNMB3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KCNMB3 Gene

genes like me logo Genes that share paralogs with KCNMB3: view

Variants for KCNMB3 Gene

Sequence variations from dbSNP and Humsavar for KCNMB3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1055071 -- 179,243,540(-) ATGAA(A/G/T)TTGGT intron-variant
rs1059690 -- 179,243,192(-) GGAAC(C/T)CCCTT intron-variant, reference, synonymous-codon, nc-transcript-variant
rs1059691 -- 179,242,819(-) ACTAA(C/T)AATGT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1170672 - 179,250,872(+) GCACA(C/T)CTAGT reference, missense, nc-transcript-variant
rs1170673 -- 179,252,222(+) cctac(A/G)gtgtc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNMB3 Gene

Variant ID Type Subtype PubMed ID
dgv5352n71 CNV Loss 21882294
nsv829806 CNV Gain 17160897
nsv471116 CNV Gain 18288195

Relevant External Links for KCNMB3 Gene

HapMap Linkage Disequilibrium report
KCNMB3
Human Gene Mutation Database (HGMD)
KCNMB3

Disorders for KCNMB3 Gene

Relevant External Links for KCNMB3

Genetic Association Database (GAD)
KCNMB3
Human Genome Epidemiology (HuGE) Navigator
KCNMB3
genes like me logo Genes that share disorders with KCNMB3: view

No data available for UniProtKB/Swiss-Prot for KCNMB3 Gene

Publications for KCNMB3 Gene

  1. Identification of a putative regulatory subunit of a calcium- activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. (PMID: 10585773) Riazi M.A. … McDermid H.E. (Genomics 1999) 2 3 4
  2. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PMID: 10692449) Brenner R. … Aldrich R.W. (J. Biol. Chem. 2000) 3 4
  3. Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. (PMID: 18591419) Zeng X. … Lingle C.J. (J. Gen. Physiol. 2008) 3 23
  4. Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel. (PMID: 10766764) Uebele V.N. … Swanson R. (J. Biol. Chem. 2000) 3 4
  5. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PMID: 10792058) Meera P. … Toro L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for KCNMB3 Gene

Sources for KCNMB3 Gene

Back to Top

Content