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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB2 Gene

protein-coding   GIFtS: 54
GCID: GC03P177990

Potassium Large Conductance Calcium-Activated Channel, Subfamily...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M,
Beta Member 21 2
     MaxiK Channel Beta 2 Subunit2
Charybdotoxin Receptor Subunit Beta-22 3     slo-beta-22
BK Channel Subunit Beta-22 3     BKbeta23
Calcium-Activated Potassium Channel Subunit Beta-22     Hbeta23
hCG16464712     Hbeta33
hbeta22     K(VCA)beta-23
k(VCA)beta-22     Slo-beta-23
Large Conductance Calcium-Activated Potassium Channel Beta 2 Subunit2     Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-23
Large-Conductance Ca2+-Activated K+ Channel Beta2 Subunit2     Maxi K Channel Subunit Beta-23

External Ids:    HGNC: 62861   Entrez Gene: 102422   Ensembl: ENSG000001975847   OMIM: 6052145   UniProtKB: Q9Y6913   

Export aliases for KCNMB2 gene to outside databases

Previous GC identifers: GC03M181111 GC03U900023 GC03P179656 GC03P179575 GC03P179736 GC03P175660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNMB2 Gene:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to
the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the
pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta
subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in
multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full
length nature has not been described. (provided by RefSeq, Jul 2013)

GeneCards Summary for KCNMB2 Gene: 
KCNMB2 (potassium large conductance calcium-activated channel, subfamily M, beta member 2) is a protein-coding gene. Diseases associated with KCNMB2 include insulinoma, and lymphoblastic leukemia, and among its related super-pathways are cGMP effects and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel inhibitor activity and potassium channel regulator activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative
regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1
inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons

summary for KCNMB2 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB2 gene promoter:
         LHX3b/Lhx3b   GATA-3   SEF-1 (1)   CUTL1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNMB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.32   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.32

KCNMB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P177990:  view genomic region     (about GC identifiers)

Start:
177,990,720 bp from pter      End:
178,562,217 bp from pter
Size:
571,498 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-2  
Size: 235 amino acids; 27130 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for KCNMB2:
1JO6 (3D)    

Explore the universe of human proteins at neXtProt for KCNMB2: NX_Q9Y691

Explore proteomics data for KCNMB2 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y691

  • KCNMB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNMB2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265840.1  NP_005823.1  NP_852006.1  

    ENSEMBL proteins: 
     ENSP00000395807   ENSP00000408252   ENSP00000397483   ENSP00000407592   ENSP00000399100  
     ENSP00000414228   ENSP00000351068  
    Reactome Protein details: Q9Y691
    Human Recombinant Protein Products for KCNMB2: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----

    KCNMB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels

    2 InterPro protein domains:
     IPR003930 K_chnl_Ca-activ_BK_bsu
     IPR015382 KCNMB2_ball_chain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y691

    ProtoNet protein and cluster: Q9Y691

    1 Blocks protein domain: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
    Domain: The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of
    KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues
    20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a
    well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its
    C-terminus
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily


    KCNMB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMB2_HUMAN, Q9Y691
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative
    regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1
    inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008200ion channel inhibitor activity TAS10097176
    GO:0015269calcium-activated potassium channel activity IDA10692449
    GO:0015459potassium channel regulator activity TAS10097176
         
    KCNMB2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNMB2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase0.75
    Platelet homeostasis0.34
    cGMP effects0.75
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Potassium Channels
    Potassium Channels0.43
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Insulin secretion
    Insulin secretion0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for KCNMB2 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    2         Kegg Pathways  (Kegg details for KCNMB2):
        Vascular smooth muscle contraction
    Insulin secretion


    KCNMB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNMB2 (ENSP000003510684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKG1ENSP000003630924STRING: ENSP00000363092
    PRKXENSP000002628484STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--

    KCNMB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNMB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNMB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for KCNMB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313
    (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium-- --target----

    Search CenterWatch for drugs/clinical trials and news about KCNMB2 / KCMB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNMB2 gene (3 alternative transcripts): 
    NM_001278911.1  NM_005832.4  NM_181361.2  

    Unigene Cluster for KCNMB2:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 2
    Hs.478368  [show with all ESTs]
    Unigene Representative Sequence: AF209747
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437510 ENST00000420517 ENST00000470361 ENST00000452583 ENST00000432997(uc003fjd.3 uc003fje.3 uc003fjf.3 uc011bqb.2)
    ENST00000455865 ENST00000422927 ENST00000436247 ENST00000358316(uc011bqa.2)

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    Additional mRNA sequence: 

    AB193524.1 AB193525.1 AB193526.1 AB193527.1 AB193528.1 AB193529.1 AB193530.1 AF099137.1 
    AF209747.1 AK298291.1 BC017825.1 

    7 DOTS entries:

    DT.70100591  DT.95222498  DT.404351  DT.97783345  DT.120853096  DT.100695555  DT.91739157 

    24/30 AceView cDNA sequences (see all 30):

    NM_181361 BQ286029 BM974129 BF434939 NM_005832 AA952936 BG185231 BG188850 
    BU950418 AI299145 BM983559 AI457816 AF209747 AI791525 AI301175 AF099137 
    BQ269391 BG502844 AI733035 BF478158 BC017825 BG195580 AA910198 BG701449 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:        -     -                           
    SP2:        -                                 
    SP3:                                          


    ECgene alternative splicing isoforms for KCNMB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB2 expression in normal human tissues (normalized intensities)      KCNMB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNMB2 Expression
    About this image


    KCNMB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
             oocyte   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   

     -- (Endocrine System)
             pituitary gland   

    See KCNMB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB2

    SOURCE GeneReport for Unigene cluster: Hs.478368

    UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
    Tissue specificity: Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in
    other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnmb21 , 5 potassium large conductance calcium-activated channel, more1, 5 88.65(n)1
    95.32(a)1
      3 (15.48 cM)5
    724131  NM_028231.21  NP_082507.11 
     319025075 
    chicken
    (Gallus gallus)
    Aves KCNMB21 potassium large conductance calcium-activated channel, more 81.56(n)
    92.77(a)
      770907  XM_003641775.1  XP_003641823.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNMB26
    --
    Uncharacterized protein
    89(a)
    78(a)
    1 ↔ many
    1 ↔ many
    3(2456598-2456885)
    AAWZ02039013(7499-7971)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.133352 Transcribed sequence with moderate similarity to protein more 81.02(n)    BX729097.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7967531 calcium-activated potassium channel subunit beta-2-like 59.08(n)
    55.36(a)
      796753  XM_001337104.2  XP_001337140.2 


    ENSEMBL Gene Tree for KCNMB2 (if available)
    TreeFam Gene Tree for KCNMB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB2 gene
    KCNMB42  KCNMB32  KCNMB12  
    3 SIMAP similar genes for KCNMB2 using alignment to 12 protein entries:     KCMB2_HUMAN (see all proteins):
    KCNMB3    KCNMB1    KCNMB4

    KCNMB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6530 SNPs in KCNMB2 are shown (see all 6530)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112798381,2
    C--175799636(+) TAAAG-/AGT   
       GCAAG
    TTAGC
    1 -- int11Minor allele frequency- AGTGCAAG:0.00NA 2
    rs676905741,2
    C--175863047(+) TACTG-/AATC  
            
    AGTCT
    1 -- int10--------
    rs611487611,2
    C--175875711(+) AAAAA-/A/AAA 
            
    GCAGT
    1 -- int11NA 2
    rs1112325871,2
    C--178144924(+) AAAAA-/ATTGAG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1874640521,2
    --178252242(+) ACAAAC/TACTTT 1 -- us2k10--------
    rs1927489061,2
    --178252354(+) CTTTTC/TGGAGT 1 -- us2k10--------
    rs622847881,2
    C--178252369(+) ATACTC/TACACT 1 -- us2k14Minor allele frequency- T:0.26NA WA EA 360
    rs1431368651,2
    --178252509(+) GACCAC/TGAGGC 1 -- us2k10--------
    rs560267861,2
    C--178252532(+) TTGGAC/TTCTTA 1 -- us2k10--------
    rs1907676541,2
    --178252586(+) ATTTGA/GAAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNMB2 (177990720 - 178240720 bp, first 250kb of KCNMB2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for KCNMB2 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2536068CNV Deletion19546169
    esv2726250CNV Deletion23290073
    esv1066766CNV Deletion17803354
    esv2726254CNV Deletion23290073
    esv2299103CNV Deletion18987734
    esv1084850CNV Deletion17803354
    esv2666875CNV Deletion23128226
    esv2726253CNV Deletion23290073
    esv1105229CNV Deletion17803354
    esv2726249CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605214    OMIM disorders: --

    5 diseases for KCNMB2:    About MalaCards
    insulinoma    lymphoblastic leukemia    hypoxia    neuronitis
    leukemia


    KCNMB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNMB2

    Export disorders for KCNMB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with KCNMB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. (PubMed id 10097176)1, 2, 3 Wallner M.... Toro L. (1999)
    2. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1, 4 TreviA+o L.R....Relling M.V. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. (PubMed id 12566540)1, 2 Xia X.-M.... Lingle C.J. (2003)
    5. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
    6. NMR structure of the 'ball-and-chain' domain of KCNMB2, the beta 2- subunit of large conductance Ca2+- and voltage-activated potassium channels. (PubMed id 11517232)1, 2 Bentrop D.... Fakler B. (2001)
    7. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
    8. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PubMed id 10692449)1, 2 Brenner R.... Aldrich R.W. (2000)
    9. Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. (PubMed id 10377337)1, 2 Xia X.-M.... Lingle C.J. (1999)
    10. Genome-wide association analyses identify multiple loc i associated with central corneal thickness and keratoconus. (PubMed id 23291589)1 Lu Y....Wong T.Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10242 HGNC: 6286 AceView: KCNMB2 Ensembl:ENSG00000197584 euGenes: HUgn10242
    ECgene: KCNMB2 Kegg: 10242 H-InvDB: KCNMB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNMB2 gene:
    Search GeneIP for patents involving KCNMB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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