Aliases for KCNMB2 Gene
- Potassium Channel Subfamily M Regulatory Beta Subunit 2 2 3
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 2 3
- Charybdotoxin Receptor Subunit Beta-2 3 4
- Big Potassium Channel Beta Subunit 2 2 3
- MaxiK Channel Beta-Subunit 2 2 3
- BK Channel Beta Subunit 2 2 3
- BK Channel Subunit Beta-2 3 4
- K(VCA)Beta-2 3 4
- Slo-Beta-2 3 4
- Hbeta2 3 4
External Ids for KCNMB2 Gene
Previous GeneCards Identifiers for KCNMB2 Gene
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
GeneCards Summary for KCNMB2 Gene
KCNMB2 (Potassium Channel Subfamily M Regulatory Beta Subunit 2) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include potassium channel regulator activity and ion channel inhibitor activity. An important paralog of this gene is KCNMB4.
UniProtKB/Swiss-Prot for KCNMB2 Gene
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.