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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB2 Gene

protein-coding   GIFtS: 53
GCID: GC03P177990

potassium large conductance calcium-activated channel, subfamily...
 Explore 5 diseases affiliated with
KCNMB2 via
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 Human Malady Compendium 
Biological research products
for KCNMB2    

Aliases
for KCNMB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta
Member 21 2
     K(VCA)Beta-21
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-22 3     Large Conductance Calcium-Activated Potassium Channel Beta 2 Subunit2
Charybdotoxin Receptor Subunit Beta-22 3     Large-Conductance Ca2+-Activated K+ Channel Beta2 Subunit2
Maxi K Channel Subunit Beta-22 3     MaxiK Channel Beta 2 Subunit2
BKbeta22 3     Slo-Beta-21
BK Channel Subunit Beta-22 3     Hbeta23
Calcium-Activated Potassium Channel Subunit Beta-22     Hbeta33
HCG16464711     K(VCA)Beta-21
Hbeta23     Slo-Beta-21
Hbeta33     

External Ids:    HGNC: 62861   Entrez Gene: 102422   Ensembl: ENSG000001975847   OMIM: 6052145   UniProtKB: Q9Y6913   

Export aliases for KCNMB2 gene to outside databases

Previous GC identifers: GC03M181111 GC03U900023 GC03P179656 GC03P179575 GC03P179736 GC03P175660


Summaries
for KCNMB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNMB2:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the
control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming
alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which
decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found
for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative
regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1
inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons

summary for KCNMB2:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB2


Genomic Views
for KCNMB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB2 gene promoter:
         LHX3b/Lhx3b   GATA-3   SEF-1 (1)   CUTL1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNMB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.32   Ensembl cytogenetic band:  3q26.32   HGNC cytogenetic band: 3q26.32

KCNMB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P177990:  view genomic region     (about GC identifiers)

Start:
 177,990,720 bp from pter      End:
 178,562,217 bp from pter
Size:
 571,498 bases      Orientation:
 plus strand

Proteins
for KCNMB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-2  
Size: 235 amino acids; 27130 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for KCNMB2:
1JO6 (3D)    

Explore the universe of human proteins at neXtProt for KCNMB2: NX_Q9Y691

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y691

    • KCNMB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005823.1  NP_852006.1  

    ENSEMBL proteins: 
     ENSP00000395807   ENSP00000408252   ENSP00000397483   ENSP00000407592   ENSP00000399100  
     ENSP00000414228   ENSP00000351068  
    Reactome Protein details: Q9Y691
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA10692449
    GO:0008076voltage-gated potassium channel complex IDA10692449
    GO:0016020membrane ----


    KCNMB2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCNMB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNMB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003930 K_chnl_Ca-activ_BK_bsu
     IPR015382 KCNMB2_ball_chain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y691

    ProtoNet protein and cluster: Q9Y691

    1 Blocks protein family: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
    Domain: The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1
    channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it
    to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered
    loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily


    Function
    for KCNMB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative
    regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1
    inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons

    miRNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005267potassium channel activity ----
    GO:0008200ion channel inhibitor activity TAS10097176
    GO:0015269calcium-activated potassium channel activity IDA10692449
    GO:0015459potassium channel regulator activity TAS10097176


    KCNMB2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KCNMB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    		cGMP effects0.75
    2Potassium Channels
    		Potassium Channels1.00
    3Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67
    5Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for KCNMB2 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    1         Kegg Pathway  (Kegg details for KCNMB2):
        Vascular smooth muscle contraction


    KCNMB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNMB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNMB2 (ENSP000003510684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKG1ENSP000003630924STRING: ENSP00000363092
    PRKXENSP000002628484STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001508regulation of action potential IDA10692449
    GO:0005513detection of calcium ion IDA10692449
    GO:0006813potassium ion transport IDA10692449
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--


    KCNMB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNMB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNMB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNMB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for KCNMB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313
    (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium-- --target----

    Search CenterWatch for drugs/clinical trials and news about KCNMB2 / KCMB2 

    Transcripts
    for KCNMB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNMB2 gene (2 alternative transcripts): 
    NM_005832.3  NM_181361.1  

    Unigene Cluster for KCNMB2:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 2
    Hs.478368  [show with all ESTs]
    Unigene Representative Sequence: AF209747
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437510 ENST00000420517 ENST00000452583 ENST00000470361 ENST00000432997(uc003fjd.3 uc003fje.3 uc003fjf.3 uc011bqb.2)
    ENST00000455865 ENST00000422927 ENST00000436247 ENST00000358316(uc011bqa.2)


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    hsa-miR-448 hsa-miR-137 hsa-miR-520d-5p hsa-miR-16-1* hsa-miR-144 hsa-miR-9 hsa-miR-3121-3p hsa-miR-3163
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB193524.1 AB193525.1 AB193526.1 AB193527.1 AB193528.1 AB193529.1 AB193530.1 AF099137.1 
    AF209747.1 AK298291.1 BC017825.1 

    7 DOTS entries:

    DT.70100591  DT.95222498  DT.404351  DT.97783345  DT.120853096  DT.100695555  DT.91739157 

    24/30 AceView cDNA sequences (see all 30):

    NM_181361 BQ286029 NM_005832 AA952936 BF434939 BM974129 BG188850 AI299145 
    AF209747 BF478158 AI457816 BG502844 BC017825 AF099137 AI733035 AI301175 
    BQ269391 BG195580 BM983559 AA910198 AI791525 BG185231 BU950418 BG701449 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:        -     -                           
    SP2:        -                                 
    SP3:                                          


    ECgene alternative splicing isoforms for KCNMB2

    Expression
    for KCNMB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNMB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNMB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB2

    SOURCE GeneReport for Unigene cluster: Hs.478368

    UniProtKB/Swiss-Prot: KCMB2_HUMAN, Q9Y691
    Tissue specificity: Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other
    tissues

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    In Situ
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    Orthologs
    for KCNMB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB2 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNMB21 potassium large conductance calcium-activated channel, more 81.56(n)
    92.77(a)    		   770907  XM_003641775.1  XP_003641823.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNMB26
    --
    		 --
    		 89(a)
    80(a)
    		 1 ↔ 1
    possible ortholog
    		 3(2456598-2456885)
    AAWZ02039013(7499-7971)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.133352 Transcribed sequence with moderate similarity to protein more 81.02(n)    BX729097.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7967531 calcium-activated potassium channel subunit beta-2-like 59.08(n)
    55.36(a)    		   796753  XM_001337104.2  XP_001337140.2 


    ENSEMBL Gene Tree for KCNMB2 (if available)
    TreeFam Gene Tree for KCNMB2 (if available) 

    Paralogs
    for KCNMB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB2 gene
    KCNMB42  KCNMB32  KCNMB12  
    3 SIMAP similar genes for KCNMB2 using alignment to 12 protein entries:     KCMB2_HUMAN (see all proteins):
    KCNMB3    KCNMB1    KCNMB4

    KCNMB2 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNMB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5563 NCBI SNPs in KCNMB2 are shown (see all 5563)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1874640521,2
    		--178252242(+) ACAAAC/TACTTT 1 -- us2k10--------
    rs1927489061,2
    		--178252354(+) CTTTTC/TGGAGT 1 -- us2k10--------
    rs622847881,2
    		C,--178252369(+) ATACTC/TACACT 1 -- us2k14Minor allele frequency- T:0.26NA WA EA 360
    rs1431368651,2
    		--178252509(+) GACCAC/TGAGGC 1 -- us2k10--------
    rs560267861,2
    		--178252532(+) TTGGAC/TTCTTA 1 -- us2k10--------
    rs1907676541,2
    		--178252586(+) ATTTGA/GAAAAG 1 -- us2k10--------
    rs1470702431,2
    		--178252593(+) AAAGTA/CTTTTT 1 -- us2k10--------
    rs666494561,2
    		C--178252630(+) AAAGATTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1920517961,2
    		--178252660(+) GCAATA/GAGTAT 1 -- us2k10--------
    rs342114561,2
    		C,F,--178252718(+) GAGAAC/TAAAAT 1 -- us2k16Minor allele frequency- T:0.19NA EA 248

    HapMap Linkage Disequilibrium report for KCNMB2 (177990720 - 178240720 bp, first 250kb of KCNMB2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for KCNMB2
         5 CNVs: 98545 59110 63675 51022 62127
         9 Indels: 27228 60444 27226 27227 12355 40581 63674 46337 12356

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    Disorders / Diseases
    for KCNMB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNMB2 for disorders           About GeneDecksing

    OMIM gene information: 605214    OMIM disorders: --

    5 diseases for KCNMB2:    About MalaCards
    neuronitis    lymphoblastic leukemia    insulinoma    leukemia
    hypoxia


    Export disorders for KCNMB2 gene to outside databases

    Publications
    for KCNMB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with KCNMB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. (PubMed id 10097176)1, 2, 3 Wallner M.... Toro L. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. (PubMed id 12566540)1, 2 Xia X.-M.... Lingle C.J. (2003)
    4. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)
    5. NMR structure of the 'ball-and-chain' domain of KCNMB2, the beta 2- subunit of large conductance Ca2+- and voltage-activated potassium channels. (PubMed id 11517232)1, 2 Bentrop D.... Fakler B. (2001)
    6. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. (PubMed id 10792058)1, 2 Meera P.... Toro L. (2000)
    7. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. (PubMed id 10692449)1, 2 Brenner R.... Aldrich R.W. (2000)
    8. Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. (PubMed id 10377337)1, 2 Xia X.-M.... Lingle C.J. (1999)
    9. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    External Searches for KCNMB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KCNMB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10242 HGNC: 6286 AceView: KCNMB2 Ensembl:ENSG00000197584 euGenes: HUgn10242
    ECgene: KCNMB2 Kegg: 10242 H-InvDB: KCNMB2

    Other Databases showing KCNMB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNMB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNMB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNMB2 gene:
    Search GeneIP for patents involving KCNMB2

    GeneCards and IP:
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