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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNMB1 Gene

protein-coding   GIFtS: 61
GCID: GC05M169737

potassium large conductance calcium-activated channel, subfamily...
 Explore 12 diseases affiliated with
KCNMB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNMB1    

Aliases
for KCNMB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta
Member 11 2
     Hbeta13
Hslo-Beta1     K(VCA)Beta-11
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-12 3     Large Conductance Ca2+-Activated K+ Channel Beta 1 Subunit2
Charybdotoxin Receptor Subunit Beta-12 3     Maxi K Channel Beta Subunit2
Maxi K Channel Subunit Beta-12 3     Slo-Beta-11
BKbeta12 3     BKbeta3
BK Channel Subunit Beta-12 3     Hbeta13
K(VCA)Beta1     K(VCA)Beta-11
SLO-BETA2     Slo-Beta1
BK Channel Beta Subunit2     Slo-Beta-11
Calcium-Activated Potassium Channel Subunit Beta-12     Calcium-Activated Potassium Channel Subunit Beta3

External Ids:    HGNC: 62851   Entrez Gene: 37792   Ensembl: ENSG000001459367   OMIM: 6039515   UniProtKB: Q165583   

Export aliases for KCNMB1 gene to outside databases

Previous GC identifers: GC05M170040 GC05M170508 GC05M169740 GC05M169786 GC05M164904


Summaries
for KCNMB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNMB1:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the
control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming
alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical
association between the alpha and beta subunits. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent
Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its
pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a
negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a
requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and
for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin
(CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

summary for KCNMB1:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB1


Genomic Views
for KCNMB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNMB1 gene promoter:
         TBP   SRF   Tal-1   SRF (504 AA)   XBP-1   AP-4   FOXL1   E47   MZF-1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNMB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNMB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q34

KCNMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M169737:  view genomic region     (about GC identifiers)

Start:
 169,805,167 bp from pter      End:
 169,816,681 bp from pter
Size:
 11,515 bases      Orientation:
 minus strand

Proteins
for KCNMB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-1  
Size: 191 amino acids; 21797 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00707 O00708 P78475 Q53YR0 Q8TAX3 Q93005
Alternative splicing: 2 isoforms:  Q16558-1   Q16558-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNMB1: NX_Q16558

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16558

    • KCNMB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004128.1  
    ENSEMBL proteins: 
     ENSP00000274629   ENSP00000427940  
    Reactome Protein details: Q16558
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    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016021integral to membrane ----


    KCNMB1 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for KCNMB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNMB1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q16558

    ProtoNet protein and cluster: Q16558

    1 Blocks protein family: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily


    Function
    for KCNMB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent
    Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its
    pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a
    negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a
    requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and
    for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin
    (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

         Genatlas biochemistry entry for KCNMB1:
    potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of
    smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth muscle tissues like
    small intestine,colon,uterus,aorta,see KCNMA1

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    SwitchGear 3'UTR luciferase reporter plasmid: KCNMB1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015269calcium-activated potassium channel activity IEA--
    GO:0015459potassium channel regulator activity IEA--


    KCNMB1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Kcnmb1tm1Pong for KCNMB1
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnmb1):
     cardiovascular system  hearing/vestibular/ear  muscle  renal/urinary system 

    KCNMB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNMB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nitric oxide stimulates guanylate cyclase
    		Nitric oxide stimulates guanylate cyclase1.00
    		Platelet homeostasis0.34
    		cGMP effects0.75
    2Potassium Channels
    		Potassium Channels1.00
    3Ca2+ activated K+ channels
    		Ca2+ activated K+ channels1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67
    5Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for KCNMB1 (see all 7)
        Hemostasis
    Potassium Channels
    Ca2+ activated K+ channels
    cGMP effects
    Platelet homeostasis


    1         Kegg Pathway  (Kegg details for KCNMB1):
        Vascular smooth muscle contraction


    KCNMB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNMB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/15 Interacting proteins for KCNMB1 (Q165582, 3 ENSP000002746294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLCA1A8K7I43, ENSP000002347014STRING: ENSP00000234701 I2D: score=2 
    MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
    KCNMA1Q127913, ENSP000002866274I2D: score=2 STRING: ENSP00000286627
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    SHCBP1Q8NEM23I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8799178
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--
    GO:0051592response to calcium ion IEA--


    KCNMB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNMB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNMB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for KCNMB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNMB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNMB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    3 Novoseek chemical compound relationships for KCNMB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetrandrine 75.4 2 8764643 (1), 12007141 (1)
    potassium 67.5 5 10828459 (2), 8764643 (1), 8799178 (1), 10692449 (1)
    calcium 25 6 10828459 (3), 11985543 (1), 8799178 (1), 10692449 (1)

    1 PharmGKB related drug/compound annotation for KCNMB1 gene
    Drug/compound PharmGKB Annotation
    verapamilCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about KCNMB1 / KCMB1 

    Transcripts
    for KCNMB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNMB1 gene: 
    NM_004137.3  

    Unigene Cluster for KCNMB1:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 1
    Hs.484099  [show with all ESTs]
    Unigene Representative Sequence: BC025707
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274629(uc003maq.1) ENST00000521859(uc003mar.3)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF026002.1 AK313979.1 AY044441.1 AY515264.1 BC025707.1 U25138.1 U38907.1 U42600.1 
    U61536.1 

    3 DOTS entries:

    DT.314578  DT.75169130  DT.92417786 

    24/62 AceView cDNA sequences (see all 62):

    AI149650 AI341809 U42600 CD516242 NM_004137 AA464625 AF026002 BX103056 
    U38907 AY044441 AA447713 CA426968 CD367598 AA029299 AI619439 BU731162 
    AI309617 AW953038 BI835962 BQ072610 BU617276 AA447869 BM694558 AA594611 

    GeneLoc Exon Structure


    Expression
    for KCNMB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNMB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNMB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNMB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNMB1

    SOURCE GeneReport for Unigene cluster: Hs.484099

    UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Tissue specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the
    brain, relatively high levels found in hippocampus and corpus callosum

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    In Situ
    Assay Products:     
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    Orthologs
    for KCNMB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcnmb11 , 5 potassium large conductance calcium-activated channel, more1, 5 84.47(n)1
    82.72(a)1    		   11 (19.32 cM)5
    165331  NM_031169.41  NP_112446.21 
     339630135 
    chicken
    (Gallus gallus)    		 Aves KCNMB11 potassium large conductance calcium-activated channel, more 58.99(n)
    47.12(a)    		   395301  NM_204602.1  NP_989933.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CR855338.16
    kcnmb26
    		 --
    potassium large conductance calcium-activated chan...
    		 29(a)
    29(a)
    		 many ↔ many
    many ↔ many
    		 11(8388864-8402037)
    2(7602709-7613741)


    ENSEMBL Gene Tree for KCNMB1 (if available)
    TreeFam Gene Tree for KCNMB1 (if available) 

    Paralogs
    for KCNMB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNMB1 gene
    KCNMB22  KCNMB42  KCNMB32  
    2 SIMAP similar genes for KCNMB1 using alignment to 1 protein entry:     KCMB1_HUMAN:
    KCNMB2    KCNMB3

    KCNMB1 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNMB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Polymorphism: Genetic variation in KCNMB1 can influence the severity of diastolic hypertension


    10/320 NCBI SNPs in KCNMB1 are shown (see all 320)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs117391361,2
    		C,F,H,pathogenic176014970(+) CAGCTC/TCTCCT 1 -- int1 ese324Minor allele frequency- T:0.10NS EA NA WA EU 12391
    rs346133751,2
    		C,F--164903859(+) GACACG/ACTCTT 1 -- int12Minor allele frequency- A:0.50NA 4
    rs455304351,2
    		C,F,--164904476(-) TTCCAG/CTCCAA 1 -- int12Minor allele frequency- C:0.08WA 238
    rs1121211551,2
    		C--164904550(+) CAGTCC/G/TCCTGT 1 -- int11CSA 1
    rs125153311,2
    		C,F,H,--164905931(+) GCAAGC/TGGGTA 1 -- int17Minor allele frequency- T:0.05NS EA CSA WA 533
    rs800922991,2
    		C,--164906188(+) CCCAGG/ATCCCT 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs733256531,2
    		C,--164906216(+) GAGGGC/TGAGAC 1 -- int12Minor allele frequency- T:0.02WA 120
    rs125186281,2
    		C,F,A,H,--164906331(+) ATTCCT/CTGCAG 1 -- int16Minor allele frequency- C:0.05NS EA CSA WA 537
    rs125186331,2
    		C,F,A,H,--164906367(+) TGAGGT/CGCCAC 1 -- int118Minor allele frequency- C:0.06NS EA NA CSA WA 1909
    rs1118945621,2
    		--164906599(+) GCTGAC/TGGTGA 1 -- int13Minor allele frequency- T:0.11CSA WA 121

    HapMap Linkage Disequilibrium report for KCNMB1 (169805167 - 169816681 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNMB1: --
    Human Gene Mutation Database (HGMD): KCNMB1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNMB1
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    Disorders / Diseases
    for KCNMB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNMB1 for disorders           About GeneDecksing

    OMIM gene information: 603951   
    OMIM disorders: 608622  
    12 diseases for KCNMB1:    About MalaCards
    hypertension, diastolic, resistance to    corpus callosum    sleep apnea    apnea
    neuronitis    essential hypertension    hypertension    myocarditis
    kidney disease    asthma    cholesterol    hypoxia

    Genetic Association Database (GAD): KCNMB1
    Human Genome Epidemiology (HuGE) Navigator: KCNMB1 (16 documents)

    Export disorders for KCNMB1 gene to outside databases

    Publications
    for KCNMB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNMB1 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with KCNMB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PubMed id 8799178)1, 2, 3, 9 Tseng-Crank J.... Reinhart P.H. (1996)
    2. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. (PubMed id 8764643)1, 2, 9 Dworetzky S.I.... Gribkoff V.K. (1996)
    3. The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PubMed id 12011654)1, 4, 9 Gollasch M....Bahring S. (2002)
    4. Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. (PubMed id 16293791)1, 4 Senti M....Valverde M.A. (2005)
    5. E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients. (PubMed id 16155733)1, 4 Via M....Moral P. (2005)
    6. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study. (PubMed id 15671602)1, 4 Kokubo Y....Tomoike H. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. (PubMed id 15057310)1, 2 Fernandez-Fernandez J.M.... Valverde M.A. (2004)
    9. Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. (PubMed id 12434576)1, 2 Mazzone J.N.... Buxton I.L.O. (2002)
    10. New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044)1, 2 Orio P.... Latorre R. (2002)

    External Searches for KCNMB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KCNMB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3779 HGNC: 6285 AceView: KCNMB1 Ensembl:ENSG00000145936 euGenes: HUgn3779
    ECgene: KCNMB1 Kegg: 3779 H-InvDB: KCNMB1

    Other Databases showing KCNMB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNMB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNMB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KCNMB1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KCNMB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNMB1 gene:
    Search GeneIP for patents involving KCNMB1

    GeneCards and IP:
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