Aliases for KCNMB1 Gene
Aliases for KCNMB1 Gene
- Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1 2 3 5
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 1 2 3
- Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-1 3 4
- Potassium Channel Subfamily M Regulatory Beta Subunit 1 2 3
- Charybdotoxin Receptor Subunit Beta-1 3 4
- Big Potassium Channel Beta Subunit 1 2 3
- Maxi K Channel Subunit Beta-1 3 4
- MaxiK Channel Beta-Subunit 1 2 3
- BK Channel Beta Subunit 1 2 3
- BK Channel Subunit Beta-1 3 4
- K(VCA)Beta-1 3 4
External Ids for KCNMB1 Gene
- HGNC: 6285
- Entrez Gene: 3779
- Ensembl: ENSG00000145936
- OMIM: 603951
- UniProtKB: Q16558
Previous GeneCards Identifiers for KCNMB1 Gene
- GC05M170040
- GC05M170508
- GC05M169740
- GC05M169786
- GC05M169737
- GC05M164904
Summaries for KCNMB1 Gene
-
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNMB1 Gene
KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNMB1 include Hypertension, Diastolic. Among its related pathways are Vascular smooth muscle contraction and Insulin secretion. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is ENSG00000275163.
UniProtKB/Swiss-Prot for KCNMB1 Gene
-
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
-
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB1 Gene
Genomics for KCNMB1 Gene
Regulatory Elements for KCNMB1 Gene
Enhancers for KCNMB1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNMB1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNMB1 gene promoter:
Regulatory Element Products
Genomic Location for KCNMB1 Gene
- Chromosome:
- 5
- Start:
- 170,374,671 bp from pter
- End:
- 170,389,677 bp from pter
- Size:
- 15,007 bases
- Orientation:
- Minus strand
Genomic View for KCNMB1 Gene
Genes around KCNMB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.1 by Ensembl
- 5q35.1 by Entrez Gene
- 5q35.1 by HGNC
KCNMB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNMB1 Gene
Proteins for KCNMB1 Gene
-
Protein details for KCNMB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16558-KCMB1_HUMAN
- Recommended name:
- Calcium-activated potassium channel subunit beta-1
- Protein Accession:
- Q16558
- O00707
- O00708
- P78475
- Q53YR0
- Q8TAX3
- Q93005
Protein attributes for KCNMB1 Gene
- Size:
- 191 amino acids
- Molecular mass:
- 21797 Da
- Quaternary structure:
-
- Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.
Protein Expression for KCNMB1 Gene
Post-translational modifications for KCNMB1 Gene
- N-glycosylated.
- Glycosylation at posLast=8080 and isoforms=142
- Modification sites at PhosphoSitePlus
Other Protein References for KCNMB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for KCNMB1
-
Custom Antibody ServicesOriGene Antibodies for KCNMB1
- Novus Biologicals Antibodies for KCNMB1
- Invitrogen Antibodies for KCNMB1
- antibodies-online Antibodies for KCNMB1: See all 39
- GeneTex KCNMB1 antibody for KCNMB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNMB1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KCNMB1
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- Novus Biologicals proteins for KCNMB1
- Search GeneTex for Proteins for KCNMB1
Assay Products
No data available for DME Specific Peptides for KCNMB1 Gene
Domains & Families for KCNMB1 Gene
Gene Families for KCNMB1 Gene
Protein Domains for KCNMB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNMB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16558- Family:
-
- Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
Function for KCNMB1 Gene
Molecular function for KCNMB1 Gene
- GENATLAS Biochemistry:
- potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth muscle tissues like small intestine,colon,uterus,aorta,see KCNMA1
- UniProtKB/Swiss-Prot Function:
- Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015269 | calcium-activated potassium channel activity | TAS,IBA | -- |
| GO:0015459 | potassium channel regulator activity | TAS,IBA | -- |
Phenotypes for KCNMB1 Gene
- MGI mutant phenotypes for KCNMB1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for KCNMB1:
Animal Models for KCNMB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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ViGene Biosciences lentiviral particle packaged cDNA for KCNMB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNMB1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for KCNMB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNMB1
- GenScript: Design CRISPR guide RNA sequences for KCNMB1
miRNA for KCNMB1 Gene
- miRTarBase miRNAs that target KCNMB1
-
- hsa-mir-6807-5p (MIRT509973)
- hsa-mir-7151-3p (MIRT509974)
- hsa-mir-6075 (MIRT509975)
- hsa-mir-5095 (MIRT509976)
- hsa-mir-1292-3p (MIRT509977)
- hsa-mir-4433a-3p (MIRT509978)
- hsa-mir-6504-3p (MIRT509979)
- hsa-mir-4433b-3p (MIRT509980)
- hsa-mir-4700-3p (MIRT509981)
- hsa-mir-6715b-3p (MIRT513323)
- hsa-mir-6832-5p (MIRT513324)
- hsa-mir-4524a-3p (MIRT513325)
- hsa-mir-6715a-3p (MIRT513326)
- hsa-mir-4524b-3p (MIRT513327)
- hsa-mir-6736-5p (MIRT518666)
- hsa-mir-4701-3p (MIRT518667)
- hsa-mir-1262 (MIRT518668)
- hsa-mir-655-3p (MIRT518669)
- hsa-mir-374c-5p (MIRT518670)
- hsa-mir-4793-3p (MIRT518671)
- hsa-mir-6776-5p (MIRT518672)
- hsa-mir-3130-3p (MIRT518673)
- hsa-mir-6742-3p (MIRT518674)
- hsa-mir-7851-3p (MIRT518675)
- hsa-mir-619-3p (MIRT518676)
- hsa-mir-5089-5p (MIRT518677)
- hsa-mir-5589-5p (MIRT518678)
- hsa-mir-4731-5p (MIRT518679)
- hsa-mir-6506-5p (MIRT518680)
- hsa-mir-619-5p (MIRT518681)
- hsa-mir-512-3p (MIRT518682)
- hsa-mir-520e (MIRT518683)
- hsa-mir-520d-3p (MIRT518684)
- hsa-mir-520c-3p (MIRT518685)
- hsa-mir-520b (MIRT518686)
- hsa-mir-520a-3p (MIRT518687)
- hsa-mir-373-3p (MIRT518688)
- hsa-mir-372-3p (MIRT518689)
- hsa-mir-302e (MIRT518690)
- hsa-mir-302d-3p (MIRT518691)
- hsa-mir-302c-3p (MIRT518692)
- hsa-mir-302b-3p (MIRT518693)
- hsa-mir-302a-3p (MIRT518694)
- hsa-mir-93-5p (MIRT518695)
- hsa-mir-526b-3p (MIRT518696)
- hsa-mir-519d-3p (MIRT518697)
- hsa-mir-20b-5p (MIRT518698)
- hsa-mir-20a-5p (MIRT518699)
- hsa-mir-17-5p (MIRT518700)
- hsa-mir-106b-5p (MIRT518701)
- hsa-mir-106a-5p (MIRT518702)
- hsa-mir-4529-3p (MIRT531533)
- hsa-mir-8058 (MIRT531534)
- hsa-mir-5009-5p (MIRT531535)
- hsa-mir-1269b (MIRT531536)
- hsa-mir-1269a (MIRT531537)
- hsa-mir-432-5p (MIRT531538)
- hsa-mir-20a-3p (MIRT531539)
- hsa-mir-3156-5p (MIRT531540)
- hsa-mir-640 (MIRT649099)
- hsa-mir-378a-5p (MIRT649100)
- hsa-mir-6821-3p (MIRT649101)
- hsa-mir-6790-3p (MIRT649102)
- hsa-mir-1976 (MIRT649103)
- hsa-mir-3653-5p (MIRT649104)
- hsa-mir-6849-3p (MIRT649105)
- hsa-mir-1226-3p (MIRT649106)
- hsa-mir-6869-5p (MIRT679419)
- hsa-mir-4279 (MIRT679420)
- hsa-mir-1200 (MIRT679421)
- hsa-mir-3649 (MIRT679422)
- hsa-mir-6829-3p (MIRT679423)
- hsa-mir-6791-3p (MIRT679424)
- hsa-mir-6747-3p (MIRT679425)
- hsa-mir-6727-3p (MIRT679426)
- hsa-mir-4722-3p (MIRT679427)
- hsa-mir-544b (MIRT679428)
- hsa-mir-4324 (MIRT679429)
- hsa-mir-660-3p (MIRT679430)
- hsa-mir-140-3p (MIRT679431)
- hsa-mir-764 (MIRT679432)
- hsa-mir-552-3p (MIRT679433)
- hsa-mir-4652-3p (MIRT724282)
- hsa-mir-4743-3p (MIRT724283)
- hsa-mir-1294 (MIRT724284)
- hsa-mir-4316 (MIRT724285)
- hsa-mir-7114-3p (MIRT724286)
- hsa-mir-1180-5p (MIRT724287)
- hsa-mir-4679 (MIRT724288)
- hsa-mir-4677-3p (MIRT724289)
miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for KCNMB1 gene
Clone Products
-
OriGene ORF clones in human for KCNMB1
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for KCNMB1
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNMB1 gene
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ViGene Biosciences lentiviral particle packaged cDNA for KCNMB1 gene
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ViGene Biosciences ready-to-package AAV shRNAs for KCNMB1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNMB1 Gene
Localization for KCNMB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNMB1 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNMB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vascular smooth muscle contraction | ||
| 2 | Insulin secretion | ||
| 3 | Nitric oxide stimulates guanylate cyclase |
.01
|
|
| 4 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 5 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for KCNMB1 Gene
7 Reactome pathways for KCNMB1 Gene
3 KEGG pathways for KCNMB1 Gene
Interacting Proteins for KCNMB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005513 | detection of calcium ion | IBA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 8799178 |
| GO:0007268 | chemical synaptic transmission | TAS | 8799178 |
No data available for SIGNOR curated interactions for KCNMB1 Gene
Drugs & Compounds for KCNMB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Miconazole | Approved, Investigational, Vet_approved | Pharma | Antagonist, Pore Blocker, Target, inhibitor | 3706 | ||
| Procaine | Approved, Investigational, Vet_approved | Pharma | Channel blocker, Target, binder | 49 | ||
| Verapamil | Approved | Pharma | Channel blocker | 130 | ||
| 4-Aminopyridine | Approved | Pharma | Pore Blocker | potassium channel-blocking agent, Non-selective KV channel blocker | 69 | |
| calcium | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| HMR 1556 |
|
223749-46-0 |
|
|
(5) Tocris Compounds for KCNMB1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 4-Aminopyridine | Non-selective KV channel blocker | 504-24-5 |
| E-4031 dihydrochloride | KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) | 113559-13-0 |
| HMR 1556 | Potent and selective Iks channel blocker | 223749-46-0 |
| Linopirdine dihydrochloride | KV7 (KCNQ) channel blocker | 113168-57-3 |
| XE 991 dihydrochloride | Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents | 122955-13-9 |
Transcripts for KCNMB1 Gene
mRNA/cDNA for KCNMB1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (62) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNMB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNMB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNMB1
- GenScript: Design CRISPR guide RNA sequences for KCNMB1
miRNA Products
- Search ViGene Biosciences for KCNMB1
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for KCNMB1
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-
ViGene Biosciences ready-to-package AAV shRNAs for KCNMB1 gene
Clone Products
-
OriGene ORF clones in human for KCNMB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for KCNMB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
-
Uterus (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for KCNMB1 Gene
This gene is overexpressed in Esophagus - Muscularis (x6.8), Esophagus - Gastroesophageal Junction (x6.6), Colon - Sigmoid (x5.8), and Artery - Tibial (x4.6).
This gene is overexpressed in Prostate (35.9), Uterus (12.4), Urinary Bladder (7.8), and Seminal vesicle (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNMB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNMB1 Gene:
KCNMB1SOURCE GeneReport for Unigene cluster for KCNMB1 Gene:
Hs.484099mRNA Expression by UniProt/SwissProt for KCNMB1 Gene:
Q16558-KCMB1_HUMAN
Tissue specificity:
Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Evidence on tissue expression from TISSUES for KCNMB1 Gene
- Muscle(4.5)
- Nervous system(4.4)
- Pancreas(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for KCNMB1
-
OriGene qPCR primer pairs for KCNMB1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNMB1 Gene
Orthologs for KCNMB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNMB1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNMB1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNMB1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnmb1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnmb1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNMB1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KCNMB1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNMB1 34 |
|
||
| CO6 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | KCNMB1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CR855338.1 35 |
|
ManyToMany | |
| kcnmb2 35 |
|
ManyToMany |
- Species where no ortholog for KCNMB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNMB1 Gene
Variants for KCNMB1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for KCNMB1 Gene
- KCMB1_HUMAN-Q16558
- Genetic variation in KCNMB1 can influence the severity of diastolic hypertension (PubMed:15057310).
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11739136 | other | 170,383,792(+) | CAGCT(C/T)CTCCT | intron-variant, reference, missense | |
| rs1000096729 | -- | 170,379,889(+) | GGAGG(C/T)TGCAG | intron-variant | |
| rs1000279566 | -- | 170,385,879(+) | CTTTC(A/G)GAGAC | intron-variant | |
| rs1000329384 | -- | 170,391,433(+) | ACAAC(A/C)AAAAG | intron-variant, upstream-variant-2KB | |
| rs1000680260 | -- | 170,384,771(+) | AGGGC(A/G)TGGAC | intron-variant |
Residual Variation Intolerance Score:
77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.50;
82.21% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNMB1 Gene
Disorders for KCNMB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertension, diastolic |
|
|
Search KCNMB1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNMB1
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNMB1 Gene
Publications for KCNMB1 Gene
- Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PMID: 8799178) Tseng-Crank J. … Reinhart P.H. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
- Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit. (PMID: 17496725) Gong Y. … Johnson J.A. (Pharmacogenet. Genomics 2007) 3 22 46 64
- The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PMID: 12011654) Gollasch M. … BAohring S. (J. Hypertens. 2002) 3 22 46 64
- Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. (PMID: 8764643) Dworetzky S.I. … Gribkoff V.K. (J. Neurosci. 1996) 3 4 22 64
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
Products for KCNMB1 Gene
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for KCNMB1
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- OriGene qPCR primer pairs for KCNMB1
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- OriGene ORF clones in human for KCNMB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for KCNMB1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for KCNMB1
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- GenScript: Design CRISPR guide RNA sequences for KCNMB1
- Design optimal peptide antigens
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for KCNMB1
- Novus Biologicals proteins for KCNMB1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for KCNMB1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KCNMB1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KCNMB1 gene
- Search ViGene Biosciences for KCNMB1
- Santa Cruz Biotechnology (SCBT) Antibodies for KCNMB1
- Search Santa Cruz Biotechnology (SCBT) for KCNMB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KCNMB1
- Horizon Cell Lines for KCNMB1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNMB1
- VectorBuilder custom plasmid, inducible vectors for KCNMB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNMB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNMB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer