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Aliases for KCNMB1 Gene

Aliases for KCNMB1 Gene

  • Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1 2 3
  • Potassium Channel Subfamily M Regulatory Beta Subunit 1 2 3 5
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 1 2 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-1 3 4
  • Charybdotoxin Receptor Subunit Beta-1 3 4
  • Big Potassium Channel Beta Subunit 1 2 3
  • Maxi K Channel Subunit Beta-1 3 4
  • MaxiK Channel Beta-Subunit 1 2 3
  • BK Channel Beta Subunit 1 2 3
  • BK Channel Subunit Beta-1 3 4
  • K(VCA)Beta-1 3 4
  • Slo-Beta-1 3 4
  • SLO-BETA 3 4
  • BKbeta1 3 4
  • Hbeta1 3 4
  • Large Conductance Ca2+-Activated K+ Channel Beta 1 Subunit 3
  • Calcium-Activated Potassium Channel Subunit Beta 4
  • K(VCA)Beta 3
  • Hslo-Beta 3
  • BKbeta 4

External Ids for KCNMB1 Gene

Previous GeneCards Identifiers for KCNMB1 Gene

  • GC05M170040
  • GC05M170508
  • GC05M169740
  • GC05M169786
  • GC05M169737
  • GC05M164904

Summaries for KCNMB1 Gene

Entrez Gene Summary for KCNMB1 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNMB1 Gene

KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNMB1 include hypertension, diastolic. Among its related pathways are Platelet activation, signaling and aggregation and Transmission across Chemical Synapses. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot for KCNMB1 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

Tocris Summary for KCNMB1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNMB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB1 Gene

Genomics for KCNMB1 Gene

Regulatory Elements for KCNMB1 Gene

Promoters for KCNMB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNMB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNMB1 Gene

Chromosome:
5
Start:
170,374,671 bp from pter
End:
170,389,677 bp from pter
Size:
15,007 bases
Orientation:
Minus strand

Genomic View for KCNMB1 Gene

Genes around KCNMB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNMB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNMB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB1 Gene

Proteins for KCNMB1 Gene

  • Protein details for KCNMB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16558-KCMB1_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-1
    Protein Accession:
    Q16558
    Secondary Accessions:
    • O00707
    • O00708
    • P78475
    • Q53YR0
    • Q8TAX3
    • Q93005

    Protein attributes for KCNMB1 Gene

    Size:
    191 amino acids
    Molecular mass:
    21797 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.

    Alternative splice isoforms for KCNMB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNMB1 Gene

Proteomics data for KCNMB1 Gene at MOPED

Post-translational modifications for KCNMB1 Gene

Other Protein References for KCNMB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNMB1 Gene

Domains & Families for KCNMB1 Gene

Protein Domains for KCNMB1 Gene

Suggested Antigen Peptide Sequences for KCNMB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16558

UniProtKB/Swiss-Prot:

KCMB1_HUMAN :
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
genes like me logo Genes that share domains with KCNMB1: view

Function for KCNMB1 Gene

Molecular function for KCNMB1 Gene

GENATLAS Biochemistry:
potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth muscle tissues like small intestine,colon,uterus,aorta,see KCNMA1
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
genes like me logo Genes that share phenotypes with KCNMB1: view

Animal Models for KCNMB1 Gene

MGI Knock Outs for KCNMB1:

Animal Model Products

miRNA for KCNMB1 Gene

miRTarBase miRNAs that target KCNMB1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNMB1 Gene

Localization for KCNMB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB1 Gene COMPARTMENTS Subcellular localization image for KCNMB1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNMB1: view

Pathways & Interactions for KCNMB1 Gene

genes like me logo Genes that share pathways with KCNMB1: view

Gene Ontology (GO) - Biological Process for KCNMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA,TAS 8799178
GO:0007596 blood coagulation TAS --
GO:0071805 potassium ion transmembrane transport TAS 8612769
genes like me logo Genes that share ontologies with KCNMB1: view

No data available for SIGNOR curated interactions for KCNMB1 Gene

Drugs & Compounds for KCNMB1 Gene

(7) Drugs for KCNMB1 Gene - From: PharmGKB, Tocris, Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, Target, inhibitor 3026
Procaine Approved, Investigational Pharma Channel blocker, Target, binder 35
Verapamil Approved Pharma Channel blocker 117
calcium Nutra 0
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNMB1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4
genes like me logo Genes that share compounds with KCNMB1: view

Transcripts for KCNMB1 Gene

mRNA/cDNA for KCNMB1 Gene

Unigene Clusters for KCNMB1 Gene

Potassium large conductance calcium-activated channel, subfamily M, beta member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB1 Gene

No ASD Table

Relevant External Links for KCNMB1 Gene

GeneLoc Exon Structure for
KCNMB1
ECgene alternative splicing isoforms for
KCNMB1

Expression for KCNMB1 Gene

mRNA expression in normal human tissues for KCNMB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNMB1 Gene

This gene is overexpressed in Esophagus - Muscularis (x6.8), Esophagus - Gastroesophageal Junction (x6.6), Colon - Sigmoid (x5.8), and Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for KCNMB1 Gene

This gene is overexpressed in Prostate (35.9), Uterus (12.4), Urinary Bladder (7.8), and Seminal vesicle (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNMB1 Gene



SOURCE GeneReport for Unigene cluster for KCNMB1 Gene Hs.484099

mRNA Expression by UniProt/SwissProt for KCNMB1 Gene

Q16558-KCMB1_HUMAN
Tissue specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
genes like me logo Genes that share expression patterns with KCNMB1: view

Protein tissue co-expression partners for KCNMB1 Gene

Primer Products

In Situ Assay Products

Orthologs for KCNMB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNMB1 35
  • 99.48 (n)
  • 99.48 (a)
KCNMB1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNMB1 36
  • 85 (a)
OneToOne
KCNMB1 35
  • 87.96 (n)
  • 84.82 (a)
dog
(Canis familiaris)
Mammalia KCNMB1 35
  • 88.31 (n)
  • 85.34 (a)
KCNMB1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb1 16
Kcnmb1 35
  • 84.47 (n)
  • 82.72 (a)
Kcnmb1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNMB1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb1 35
  • 82.72 (n)
  • 82.72 (a)
chicken
(Gallus gallus)
Aves KCNMB1 35
  • 58.99 (n)
  • 47.12 (a)
CO6 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNMB1 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR855338.1 36
  • 29 (a)
ManyToMany
kcnmb2 36
  • 29 (a)
ManyToMany
Species with no ortholog for KCNMB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNMB1 Gene

ENSEMBL:
Gene Tree for KCNMB1 (if available)
TreeFam:
Gene Tree for KCNMB1 (if available)

Paralogs for KCNMB1 Gene

Paralogs for KCNMB1 Gene

(2) SIMAP similar genes for KCNMB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNMB1: view

Variants for KCNMB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNMB1 Gene

Q16558-KCMB1_HUMAN
Genetic variation in KCNMB1 can influence the severity of diastolic hypertension (PubMed:15057310).

Sequence variations from dbSNP and Humsavar for KCNMB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_019325 -
VAR_047009 -

Structural Variations from Database of Genomic Variants (DGV) for KCNMB1 Gene

Variant ID Type Subtype PubMed ID
nsv462515 CNV Loss 19166990
nsv471054 CNV Loss 18288195
nsv883106 CNV Loss 21882294

Variation tolerance for KCNMB1 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNMB1 Gene

HapMap Linkage Disequilibrium report
KCNMB1
Human Gene Mutation Database (HGMD)
KCNMB1

Disorders for KCNMB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNMB1 Gene - From: OMIM and GeneTests

Disorder Aliases PubMed IDs
hypertension, diastolic
  • hypertension, diastolic, resistance to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCNMB1

Genetic Association Database (GAD)
KCNMB1
Human Genome Epidemiology (HuGE) Navigator
KCNMB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNMB1
genes like me logo Genes that share disorders with KCNMB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNMB1 Gene

Publications for KCNMB1 Gene

  1. Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PMID: 8799178) Tseng-Crank J. … Reinhart P.H. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. (PMID: 19801679) Long X. … Miano J.M. (J. Biol. Chem. 2009) 3 23
  3. Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit. (PMID: 17496725) Gong Y. … Johnson J.A. (Pharmacogenet. Genomics 2007) 3 23
  4. The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PMID: 12011654) Gollasch M. … BAohring S. (J. Hypertens. 2002) 3 23
  5. Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. (PMID: 9888999) Jiang Z. … Toro L. (Genomics 1999) 2 3

Products for KCNMB1 Gene

Sources for KCNMB1 Gene

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