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Aliases for KCNMB1 Gene

Aliases for KCNMB1 Gene

  • Potassium Channel Subfamily M Regulatory Beta Subunit 1 2 3
  • Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 1 2 3
  • Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-1 3 4
  • Charybdotoxin Receptor Subunit Beta-1 3 4
  • Big Potassium Channel Beta Subunit 1 2 3
  • Maxi K Channel Subunit Beta-1 3 4
  • MaxiK Channel Beta-Subunit 1 2 3
  • BK Channel Beta Subunit 1 2 3
  • BK Channel Subunit Beta-1 3 4
  • K(VCA)Beta-1 3 4
  • Slo-Beta-1 3 4
  • SLO-BETA 3 4
  • BKbeta1 3 4
  • Hbeta1 3 4
  • Large Conductance Ca2+-Activated K+ Channel Beta 1 Subunit 3
  • Calcium-Activated Potassium Channel Subunit Beta-1 3
  • Calcium-Activated Potassium Channel Subunit Beta 4
  • K(VCA)Beta 3
  • Hslo-Beta 3
  • BKbeta 4

External Ids for KCNMB1 Gene

Summaries for KCNMB1 Gene

Entrez Gene Summary for KCNMB1 Gene

  • MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNMB1 Gene

KCNMB1 (Potassium Channel Subfamily M Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNMB1 include hypertension, diastolic and sleep apnea. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB4.

UniProtKB/Swiss-Prot for KCNMB1 Gene

  • Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

Tocris Summary for KCNMB1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNMB1 Gene

Genomics for KCNMB1 Gene

Genomic Location for KCNMB1 Gene

Start:
170,374,671 bp from pter
End:
170,389,677 bp from pter
Size:
15,007 bases
Orientation:
Minus strand

Genomic View for KCNMB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNMB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNMB1 Gene

Regulatory Elements for KCNMB1 Gene

Proteins for KCNMB1 Gene

  • Protein details for KCNMB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16558-KCMB1_HUMAN
    Recommended name:
    Calcium-activated potassium channel subunit beta-1
    Protein Accession:
    Q16558
    Secondary Accessions:
    • O00707
    • O00708
    • P78475
    • Q53YR0
    • Q8TAX3
    • Q93005

    Protein attributes for KCNMB1 Gene

    Size:
    191 amino acids
    Molecular mass:
    21797 Da
    Quaternary structure:
    • Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer

    Alternative splice isoforms for KCNMB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNMB1 Gene

Proteomics data for KCNMB1 Gene at MOPED

Post-translational modifications for KCNMB1 Gene

Other Protein References for KCNMB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNMB1 Gene

Domains for KCNMB1 Gene

Gene Families for KCNMB1 Gene

HGNC:
  • KCN :Potassium channels

Protein Domains for KCNMB1 Gene

UniProtKB/Swiss-Prot:

KCMB1_HUMAN
Family:
  • Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.:
    • Q16558
genes like me logo Genes that share domains with KCNMB1: view

Function for KCNMB1 Gene

Molecular function for KCNMB1 Gene

GENATLAS Biochemistry: potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth muscle tissues like small intestine,colon,uterus,aorta,see KCNMA1
UniProtKB/Swiss-Prot Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate

Gene Ontology (GO) - Molecular Function for KCNMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015269 calcium-activated potassium channel activity IEA --
GO:0015459 potassium channel regulator activity IEA --
genes like me logo Genes that share ontologies with KCNMB1: view
genes like me logo Genes that share phenotypes with KCNMB1: view

Animal Models for KCNMB1 Gene

MGI Knock Outs for KCNMB1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNMB1 Gene

Localization for KCNMB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNMB1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNMB1 Gene COMPARTMENTS Subcellular localization image for KCNMB1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KCNMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNMB1: view

Pathways for KCNMB1 Gene

genes like me logo Genes that share pathways with KCNMB1: view

Pathways by source for KCNMB1 Gene

Gene Ontology (GO) - Biological Process for KCNMB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005513 detection of calcium ion IBA --
GO:0006813 potassium ion transport TAS 8799178
GO:0007268 synaptic transmission TAS --
GO:0007596 blood coagulation TAS --
GO:0051592 response to calcium ion --
genes like me logo Genes that share ontologies with KCNMB1: view

Compounds for KCNMB1 Gene

(5) Tocris Compounds for KCNMB1 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(1) HMDB Compounds for KCNMB1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for KCNMB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Miconazole
22916-47-8 target inhibitor

(3) Novoseek inferred chemical compound relationships for KCNMB1 Gene

Compound -log(P) Hits PubMed IDs
tetrandrine 75.4 2
potassium 67.5 5
calcium 25 6

(1) PharmGKB related drug/compound annotations for KCNMB1 Gene

Drug/compound Annotation
verapamil CA
genes like me logo Genes that share compounds with KCNMB1: view

Transcripts for KCNMB1 Gene

mRNA/cDNA for KCNMB1 Gene

Unigene Clusters for KCNMB1 Gene

Potassium large conductance calcium-activated channel, subfamily M, beta member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNMB1 Gene

No ASD Table

Relevant External Links for KCNMB1 Gene

GeneLoc Exon Structure for
KCNMB1
ECgene alternative splicing isoforms for
KCNMB1

Expression for KCNMB1 Gene

mRNA expression in normal human tissues for KCNMB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNMB1 Gene

This gene is overexpressed in Esophagus - Muscularis (6.8), Esophagus - Gastroesophageal Junction (6.6), Colon - Sigmoid (5.8), and Artery - Tibial (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNMB1 Gene

SOURCE GeneReport for Unigene cluster for KCNMB1 Gene Hs.484099

mRNA Expression by UniProt/SwissProt for KCNMB1 Gene

Q16558-KCMB1_HUMAN
Tissue specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum
genes like me logo Genes that share expressions with KCNMB1: view

Orthologs for KCNMB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNMB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNMB1 36
  • 99.48 (n)
  • 99.48 (a)
KCNMB1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNMB1 36
  • 87.96 (n)
  • 84.82 (a)
KCNMB1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNMB1 36
  • 88.31 (n)
  • 85.34 (a)
KCNMB1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnmb1 36
  • 84.47 (n)
  • 82.72 (a)
Kcnmb1 16
Kcnmb1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNMB1 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNMB1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnmb1 36
  • 82.72 (n)
  • 82.72 (a)
chicken
(Gallus gallus)
Aves CO6 37
  • 45 (a)
OneToOne
KCNMB1 36
  • 58.99 (n)
  • 47.12 (a)
lizard
(Anolis carolinensis)
Reptilia KCNMB1 37
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR855338.1 37
  • 29 (a)
ManyToMany
kcnmb2 37
  • 29 (a)
ManyToMany
Species with no ortholog for KCNMB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNMB1 Gene

ENSEMBL:
Gene Tree for KCNMB1 (if available)
TreeFam:
Gene Tree for KCNMB1 (if available)

Paralogs for KCNMB1 Gene

Paralogs for KCNMB1 Gene

Selected SIMAP similar genes for KCNMB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNMB1: view

Variants for KCNMB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNMB1 Gene

Q16558-KCMB1_HUMAN
Genetic variation in KCNMB1 can influence the severity of diastolic hypertension

Sequence variations from dbSNP and Humsavar for KCNMB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_019325 -
VAR_047009 -

Structural Variations from Database of Genomic Variants (DGV) for KCNMB1 Gene

Variant ID Type Subtype PubMed ID
nsv462515 CNV Loss 19166990
nsv471054 CNV Loss 18288195
nsv883106 CNV Loss 21882294

Relevant External Links for KCNMB1 Gene

HapMap Linkage Disequilibrium report
KCNMB1
Human Gene Mutation Database (HGMD)
KCNMB1

Disorders for KCNMB1 Gene

(1) OMIM Diseases for KCNMB1 Gene (603951)

Relevant External Links for KCNMB1

Genetic Association Database (GAD)
KCNMB1
Human Genome Epidemiology (HuGE) Navigator
KCNMB1
genes like me logo Genes that share disorders with KCNMB1: view

No data available for UniProtKB/Swiss-Prot for KCNMB1 Gene

Publications for KCNMB1 Gene

  1. Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PMID: 8799178) Tseng-Crank J. … Reinhart P.H. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  2. The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PMID: 12011654) Gollasch M. … BAohring S. (J. Hypertens. 2002) 3 23 49
  3. Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit. (PMID: 17496725) Gong Y. … Johnson J.A. (Pharmacogenet. Genomics 2007) 3 23 49
  4. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. (PMID: 8764643) Dworetzky S.I. … Gribkoff V.K. (J. Neurosci. 1996) 3 4 23
  5. Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. (PMID: 19282863) Yoshida T. … Yamada Y. (Hypertens. Res. 2009) 3 49

Products for KCNMB1 Gene

Sources for KCNMB1 Gene

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