KCNMB1 Gene
protein-coding GIFtS : 61 GCID: GC05 M169737
potassium large conductance calcium-activated channel, subfamily...
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Aliasesfor KCNMB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Potassium Large Conductance Calcium-Activated Channel, Subfamily M, BetaMember 1 1 2 Hbeta13 Hslo-Beta1 K(VCA)Beta-11 Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-12 3 Large Conductance Ca2+-Activated K+ Channel Beta 1 Subunit2 Charybdotoxin Receptor Subunit Beta-12 3 Maxi K Channel Beta Subunit2 Maxi K Channel Subunit Beta-12 3 Slo-Beta-11 BKbeta12 3 BKbeta3 BK Channel Subunit Beta-12 3 Hbeta13 K(VCA)Beta1 K(VCA)Beta-11 SLO-BETA2 Slo-Beta1 BK Channel Beta Subunit2 Slo-Beta-11 Calcium-Activated Potassium Channel Subunit Beta-12 Calcium-Activated Potassium Channel Subunit Beta3
Export aliases for KCNMB1 gene to outside databases Previous GC identifers: GC05M170040 GC05M170508 GC05M169740 GC05M169786 GC05M164904
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Summariesfor KCNMB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KCNMB1 : MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 Function : Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calciumsensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate summary
for KCNMB1 : Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises theCa2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunitscontain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formedwithin subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3. Gene Wiki entry for KCNMB1
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Genomic Viewsfor KCNMB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_023133.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KCNMB1 gene promoter:TBP SRF Tal-1 SRF (504 AA) XBP-1 AP-4 FOXL1 E47 MZF-1 HSF2 Other transcription factors Search SABiosciences Chromatin IP Primers for KCNMB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q34 KCNMB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M169737: view genomic region
(about GC identifiers )
Start: 169,805,167 bp from pter End:
169,816,681 bp from pter
Size: 11,515 bases Orientation:
minus strand
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Proteinsfor KCNMB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 See
protein sequence )Recommended Name: Size : 191 amino acids; 21797 DaSubunit : Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramerSubcellular location : Membrane; Multi-pass membrane proteinSecondary accessions : O00707 O00708 P78475 Q53YR0 Q8TAX3 Q93005Alternative splicing : 2 isoforms : Q16558-1 Q16558-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCNMB1: NX_Q16558 Post-translational modifications:
N-glycosylated1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q16558 KCNMB1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004128.1 ENSEMBL proteins: ENSP00000274629 ENSP00000427940 Reactome Protein details: Q16558 Human Recombinant Protein Products for KCNMB1: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
TAS -- GO:0008076 voltage-gated potassium channel complex
IEA -- GO:0016021 integral to membrane
-- --
About GeneDecksing KCNMB1 Antibody Products: Assay Products for KCNMB1:
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Protein
Domains /for KCNMB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q16558 ProtoNet protein and cluster: Q16558
1 Blocks protein family : IPB003930 UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 Similarity : Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily
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Functionfor KCNMB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: KCMB1_HUMAN, Q16558 Function : Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calciumsensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate
Genatlas biochemistry entry for KCNMB1 potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the control of smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth muscle tissues like small intestine,colon,uterus,aorta,see KCNMA1 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0015269 calcium-activated potassium channel activity
IEA -- GO:0015459 potassium channel regulator activity
IEA --
About GeneDecksing Phenotypes: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnmb1) :About GeneDecksing Animal Models: Kcnmb1 tm1Pong for KCNMB1Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KCNMB1 (NM_004137 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNMB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KCNMB1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB1
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Pathways & Interactionsfor KCNMB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Nitric oxide stimulates guanylate cyclase 2 Potassium Channels 3 Ca2+ activated K+ channels 4 Transmission across Chemical Synapses 5 Platelet activation, signaling and aggregation
Pathway sources See GeneCards unified pathways Show all pathways 5/7 (see all 7 )1 (Kegg details for KCNMB1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNMB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)5/15 Interacting proteins for KCNMB1 (Q16558 2 , 3 ENSP00000274629 4 via UniProtKB, MINT, STRING , and/or I2D (see all 15 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
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Drugs & Compoundsfor KCNMB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for KCNMB1 available from Tocris Bioscience About this table 1 HMDB Compound for KCNMB1 About this table 1 DrugBank Compound for KCNMB1 About this table 3 Novoseek chemical compound relationships for KCNMB1 gene About this table 1 PharmGKB related drug/compound annotation for KCNMB1 gene About this table KCNMB1 / KCMB1
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Transcriptsfor KCNMB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KCNMB1 gene: NM_004137.3 Unigene Cluster for KCNMB1:
Potassium large conductance calcium-activated channel, subfamily M, beta member 1 Hs.484099 [show with all ESTs ] Unigene Representative Sequence: BC025707 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000274629 (uc003maq.1 ) ENST00000521859 (uc003mar.3 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KCNMB1 (NM_004137 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNMB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KCNMB1
Additional cDNA sequence: AF026002.1 AK313979.1 AY044441.1 AY515264.1 BC025707.1 U25138.1 U38907.1 U42600.1 U61536.1
3 DOTS entries : DT.314578 DT.75169130
DT.92417786 24/62 AceView cDNA sequences (see all 62 ):
AI149650 AI341809 U42600 CD516242 NM_004137 AA464625 AF026002 BX103056 U38907 AY044441 AA447713 CA426968 CD367598 AA029299 AI619439 BU731162 AI309617 AW953038 BI835962 BQ072610 BU617276 AA447869 BM694558 AA594611 GeneLoc Exon Structure
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Expression for KCNMB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KCNMB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image KCNMB1 expression in embryonic tissues and stem cells About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor U31 (Embryonic Progenitor Cell)Expression: Experimental details:
In-situ hybridization
See KCNMB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KCNMB1 SOURCE GeneReport for Unigene cluster: Hs.484099 UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 Tissue specificity : Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within thebrain, relatively high levels found in hippocampus and corpus callosum SABiosciences Custom PCR Arrays for KCNMB1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB1
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Orthologsfor KCNMB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KCNMB1 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for KCNMB1 (if available)TreeFam Gene Tree for KCNMB1 (if available)
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Paralogsfor KCNMB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KCNMB1 gene KCNMB2 2 KCNMB4 2 KCNMB3 2 2 SIMAP similar genes for KCNMB1 using alignment to 1 protein entry: KCMB1_HUMAN :KCNMB2 KCNMB3 About GeneDecksing
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Genomic Variantsfor KCNMB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 Polymorphism : Genetic variation in KCNMB1 can influence the severity of diastolic hypertension
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 5 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KCNMB1 (169805167 - 169816681 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KCNMB1: -- Human Gene Mutation Database (HGMD) : KCNMB1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KCNMB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603951 OMIM disorders : 608622 12 : About MalaCards hypertension, diastolic, resistance to corpus callosum sleep apnea apnea neuronitis essential hypertension hypertension myocarditis kidney disease asthma cholesterol hypoxia Genetic Association Database (GAD): KCNMB1 Human Genome Epidemiology (HuGE) Navigator: KCNMB1 (16 documents) Export disorders for KCNMB1 gene to outside databases
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Publicationsfor KCNMB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KCNMB1 gene, integrated from 9 sources (see all 60 ):(articles sorted by number of sources associating them with KCNMB1) Utopia : connect your pdf to the dynamic
Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PubMed id 8799178) 1 , 2 , 3, 9(1996) Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. (PubMed id 8764643) 1 , 2 , 9(1996) The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PubMed id 12011654) 1 , 4, 9(2002) Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. (PubMed id 16293791) 1 , 4(2005) E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients. (PubMed id 16155733) 1 , 4(2005) Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study. (PubMed id 15671602) 1 , 4(2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. (PubMed id 15057310) 1 , 2 (2004) Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. (PubMed id 12434576) 1 , 2 (2002) New disguises for an old channel: MaxiK channel beta-subunits. (PubMed id 12136044) 1 , 2 (2002)
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External Searches for KCNMB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KCNMB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KCNMB1 gene
(According to HUGE )
About This Section --
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Aliases
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Specialized Databases showing KCNMB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for KCNMB1 gene: KCNMB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KCNMB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KCNMB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KCNMB1 OriGene 3'-UTR Clone for KCNMB1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KCNMB1 OriGene Custom Protein Services for KCNMB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNMB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNMB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNMB1
Search ThermoFisher Antibodies for KCNMB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KCNMB1
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summary
for 
Kegg Pathway 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
