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KCNMB1 Gene

protein-coding   GIFtS: 61
GCID: GC05M169737

Potassium Large Conductance Calcium-Activated Channel, Subfamily...

  See KCNMB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Large Conductance Calcium-Activated Channel, Subfamily M,
Beta Member 11 2
     hslo-beta2
Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-12 3     k(VCA)beta-12
Charybdotoxin Receptor Subunit Beta-12 3     Large Conductance Ca2+-Activated K+ Channel Beta 1 Subunit2
Maxi K Channel Subunit Beta-12 3     slo-beta-12
BKbeta12 3     BKbeta3
BK Channel Subunit Beta-12 3     Hbeta13
BK Channel Beta Subunit1     K(VCA)beta-13
K(VCA)beta2     Slo-beta3
SLO-BETA2     Slo-beta-13
Calcium-Activated Potassium Channel Subunit Beta-12     Calcium-Activated Potassium Channel Subunit Beta3
hbeta12     

External Ids:    HGNC: 62851   Entrez Gene: 37792   Ensembl: ENSG000001459367   OMIM: 6039515   UniProtKB: Q165583   

Export aliases for KCNMB1 gene to outside databases

Previous GC identifers: GC05M170040 GC05M170508 GC05M169740 GC05M169786 GC05M164904


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNMB1 Gene:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to
the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the
pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium
regulates the physical association between the alpha and beta subunits. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNMB1 Gene:
KCNMB1 (potassium large conductance calcium-activated channel, subfamily M, beta member 1) is a protein-coding gene. Diseases associated with KCNMB1 include hypertension, diastolic, and sleep apnea. GO annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB2.

UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the
apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters
its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts
as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence
is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene
glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity
of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the
dissociation rate

summary for KCNMB1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNMB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNMB1 gene promoter:
         TBP   SRF   Tal-1   SRF (504 AA)   XBP-1   AP-4   FOXL1   E47   MZF-1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNMB1 promoter sequence
   Search Chromatin IP Primers for KCNMB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNMB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q34

KCNMB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNMB1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M169737:  view genomic region     (about GC identifiers)

Start:
169,801,675 bp from pter      End:
169,816,681 bp from pter
Size:
15,007 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558 (See protein sequence)
Recommended Name: Calcium-activated potassium channel subunit beta-1  
Size: 191 amino acids; 21797 Da
Subunit: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer
Secondary accessions: O00707 O00708 P78475 Q53YR0 Q8TAX3 Q93005
Alternative splicing: 2 isoforms:  Q16558-1   Q16558-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNMB1: NX_Q16558

Explore proteomics data for KCNMB1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn80, Asn142

  • See KCNMB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004128.1  
    ENSEMBL proteins: 
     ENSP00000274629   ENSP00000427940  
    Reactome Protein details: Q16558

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels

    1 InterPro protein domain:
     IPR003930 K_chnl_Ca-activ_BK_bsu

    Graphical View of Domain Structure for InterPro Entry Q16558

    ProtoNet protein and cluster: Q16558

    1 Blocks protein domain: IPB003930 Calcium-activated BK potassium channel beta subunit signature

    UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily


    Find genes that share domains with KCNMB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCMB1_HUMAN, Q16558
    Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium
    sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the
    apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters
    its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts
    as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence
    is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene
    glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity
    of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the
    dissociation rate

         Genatlas biochemistry entry for KCNMB1:
    potassium non voltage gated large conductance calcium activated channel,subfamily M,Maxik,fundamental in the
    control of smooth muscle tone and neuronal excitability,subunit,modulatory beta member 1,expressed in smooth
    muscle tissues like small intestine,colon,uterus,aorta,see KCNMA1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015269calcium-activated potassium channel activity IEA--
    GO:0015459potassium channel regulator activity IEA--
         
    Find genes that share ontologies with KCNMB1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnmb1):
     cardiovascular system  hearing/vestibular/ear  muscle  renal/urinary system 

    Find genes that share phenotypes with KCNMB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNMB1: Kcnmb1tm1Ltor Kcnmb1tm1Pong

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    SwitchGear 3'UTR luciferase reporter plasmidKCNMB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCMB1_HUMAN, Q16558: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with KCNMB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNMB1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36
    Ca2+ activated K+ channels0.00
    2Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    3Transmission across Chemical Synapses
    Neuronal System0.68
    4Hemostasis
    Hemostasis0.43
    5Potassium Channels
    Potassium Channels0.43


    Find genes that share SuperPaths with KCNMB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for KCNMB1
        Ca2+ activated K+ channels
    cGMP effects


    2 Kegg Pathways  (Kegg details for KCNMB1):
        Vascular smooth muscle contraction
    Insulin secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNMB1
    Interactions:

        GeneGlobe Interaction Network for KCNMB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for KCNMB1 (Q165582, 3 ENSP000002746294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLCA1A8K7I43, ENSP000002347014STRING: ENSP00000234701 I2D: score=2 
    MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
    KCNMA1Q127913, ENSP000002866274I2D: score=2 STRING: ENSP00000286627
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    SHCBP1Q8NEM23I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8799178
    GO:0007268synaptic transmission TAS--
    GO:0007596blood coagulation TAS--
    GO:0051592response to calcium ion IEA--
    GO:0071805potassium ion transmembrane transport TAS8612769

    Find genes that share ontologies with KCNMB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNMB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNMB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for KCNMB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Miconazole-- 22916-47-8targetinhibitor8760033 1376313

    3 Novoseek inferred chemical compound relationships for KCNMB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetrandrine 75.4 2 8764643 (1), 12007141 (1)
    potassium 67.5 5 10828459 (2), 8764643 (1), 8799178 (1), 10692449 (1)
    calcium 25 6 10828459 (3), 11985543 (1), 8799178 (1), 10692449 (1)

    1 PharmGKB related drug/compound annotation for KCNMB1 gene    About this table
    Drug/compound PharmGKB Annotation
    verapamilCA  



    Find genes that share compounds with KCNMB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNMB1 gene: 
    NM_004137.3  

    Unigene Cluster for KCNMB1:

    Potassium large conductance calcium-activated channel, subfamily M, beta member 1
    Hs.484099  [show with all ESTs]
    Unigene Representative Sequence: NM_004137
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274629(uc003maq.1) ENST00000521859(uc003mar.3)
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    Additional mRNA sequence: 

    AF026002.1 AK313979.1 AY044441.1 AY515264.1 U25138.1 U38907.1 U42600.1 U61536.1 

    3 DOTS entries:

    DT.314578  DT.75169130  DT.92417786 

    Selected AceView cDNA sequences (see all 62):

    AI619439 CD367598 AA029299 CA426968 AA447713 AI149650 U42600 AA464625 
    BX103056 NM_004137 CD516242 AI341809 U38907 AF026002 AY044441 BU731162 
    BP377746 BG185384 AI083548 AW953038 BC025707 AI093289 AA594611 AI089652 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNMB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNMB1 Expression
    About this image


    KCNMB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Uterus (Reproductive System)
    KCNMB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNMB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484099

    UniProtKB/Swiss-Prot: KCMB1_HUMAN, Q16558
    Tissue specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within
    the brain, relatively high levels found in hippocampus and corpus callosum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNMB1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnmb11 , 5 potassium large conductance calcium-activated channel, more1, 5 84.47(n)1
    82.72(a)1
      11 (19.32 cM)5
    165331  NM_031169.41  NP_112446.21 
     339630135 
    chicken
    (Gallus gallus)
    Aves KCNMB11 potassium large conductance calcium-activated channel, more 58.99(n)
    47.12(a)
      395301  NM_204602.1  NP_989933.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNMB16
    potassium large conductance calcium-activated chan...
    41(a)
    1 ↔ 1
    2(120867017-120874608)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnmb26
    CR855338.16
    Uncharacterized protein
    29(a)
    29(a)
    many ↔ many
    many ↔ many
    2(7602709-7613741) ENSDARG00000006568
    11(8388864-8402037) ENSDARG00000001712


    ENSEMBL Gene Tree for KCNMB1 (if available)
    TreeFam Gene Tree for KCNMB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNMB1 gene
    KCNMB22  KCNMB42  KCNMB32  
    2 SIMAP similar genes for KCNMB1 using alignment to 1 protein entry:     KCMB1_HUMAN:
    KCNMB2    KCNMB3

    Find genes that share paralogs with KCNMB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    KCMB1_HUMAN, Q16558: Genetic variation in KCNMB1 can influence the severity of diastolic hypertension


    2 SNPs for KCNMB1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117391361,2,4
    ----see VAR_0193252 mis40--------
    rs23011491,2,4
    ----see VAR_0470092 mis40--------

    HapMap Linkage Disequilibrium report for KCNMB1 (169801675 - 169816681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNMB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471054CNV Loss18288195
    nsv462515CNV Loss19166990
    nsv883106CNV Loss21882294

    Human Gene Mutation Database (HGMD): KCNMB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNMB1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNMB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603951   
    OMIM disorders: 608622  
    2 diseases for KCNMB1:    
    About MalaCards
    hypertension, diastolic    sleep apnea


    Find genes that share disorders with KCNMB1           About GenesLikeMe

    Genetic Association Database (GAD): KCNMB1
    Human Genome Epidemiology (HuGE) Navigator: KCNMB1 (16 documents)

    Export disorders for KCNMB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNMB1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with KCNMB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. (PubMed id 8799178)1, 2, 3, 9 Tseng-Crank J.... Reinhart P.H. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation. (PubMed id 8764643)1, 2, 9 Dworetzky S.I.... Gribkoff V.K. (J. Neurosci. 1996)
    3. Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit. (PubMed id 17496725)1, 4, 9 Gong Y....Johnson J.A. (Pharmacogenet. Genomics 2007)
    4. The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation. (PubMed id 12011654)1, 4, 9 Gollasch M....BAohring S. (J. Hypertens. 2002)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. Common charge-shift mutation Glu65Lys in K+ channel I^a88-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. (PubMed id 20861615)1, 4 Chen Y....O'Connor D.T. (Am. J. Nephrol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. (PubMed id 19050450)1, 4 Kelley-Hedgepeth A....Mitchell G.F. (J. Hypertens. 2009)
    9. Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. (PubMed id 19282863)1, 4 Yoshida T....Yamada Y. (Hypertens. Res. 2009)
    10. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3779 HGNC: 6285 AceView: KCNMB1 Ensembl:ENSG00000145936 euGenes: HUgn3779
    ECgene: KCNMB1 Kegg: 3779 H-InvDB: KCNMB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNMB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KCNMB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNMB1 gene:
    Search GeneIP for patents involving KCNMB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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