Aliases for KCNMA1 Gene
- Potassium Calcium-Activated Channel Subfamily M Alpha 1 2 3
- Potassium Channel, Calcium Activated Large Conductance Subfamily M Alpha, Member 1 2 3 5
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Alpha Member 1 2 3
- Calcium-Activated Potassium Channel, Subfamily M Subunit Alpha-1 3 4
- Big Potassium Channel Alpha Subunit 2 3
- BK Channel Alpha Subunit 2 3
- Slowpoke Homolog 3 4
- Slo Homolog 3 4
- K(VCA)Alpha 3 4
- SLO-ALPHA 3 4
- KCa1.1 3 4
- MaxiK 3 4
- SLO1 3 4
- HSlo 3 4
External Ids for KCNMA1 Gene
Previous HGNC Symbols for KCNMA1 Gene
Previous GeneCards Identifiers for KCNMA1 Gene
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNMA1 Gene
KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1) is a Protein Coding gene. Diseases associated with KCNMA1 include Generalized Epilepsy And Paroxysmal Dyskinesia and Vitreous Detachment. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include actin binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNU1.
UniProtKB/Swiss-Prot for KCNMA1 Gene
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).