Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK9 Gene

Aliases for KCNK9 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 9 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 9 2 3 5
  • Acid-Sensitive Potassium Channel Protein TASK-3 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 3 3 4
  • Two Pore Potassium Channel KT3.2 3 4
  • Two Pore K(+) Channel KT3.2 3 4
  • TASK3 3 4
  • Potassium Channel, Subfamily K, Member 9 2
  • K2p9.1 3
  • TASK-3 3
  • KT3.2 3

External Ids for KCNK9 Gene

Previous GeneCards Identifiers for KCNK9 Gene

  • GC08M140782
  • GC08M140309
  • GC08M140595
  • GC08M140693
  • GC08M135936

Summaries for KCNK9 Gene

Entrez Gene Summary for KCNK9 Gene

  • This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for KCNK9 Gene

KCNK9 (Potassium Two Pore Domain Channel Subfamily K Member 9) is a Protein Coding gene. Diseases associated with KCNK9 include Birk-Barel Mental Retardation Dysmorphism Syndrome and Intellectual Disability, Birk-Barel Type. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and potassium channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK9 Gene

  • pH-dependent, voltage-insensitive, background potassium channel protein.

Tocris Summary for KCNK9 Gene

Gene Wiki entry for KCNK9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK9 Gene

Genomics for KCNK9 Gene

Regulatory Elements for KCNK9 Gene

Enhancers for KCNK9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK9 Gene

139,600,838 bp from pter
139,703,068 bp from pter
102,231 bases
Minus strand

Genomic View for KCNK9 Gene

Genes around KCNK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK9 Gene

Proteins for KCNK9 Gene

  • Protein details for KCNK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M290
    • Q540F2

    Protein attributes for KCNK9 Gene

    374 amino acids
    Molecular mass:
    42264 Da
    Quaternary structure:
    • Homodimer (Probable). Heterodimer with KCNK1.
    • Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.
    • Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.

    Three dimensional structures from OCA and Proteopedia for KCNK9 Gene

neXtProt entry for KCNK9 Gene

Proteomics data for KCNK9 Gene at MOPED

Post-translational modifications for KCNK9 Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK9 Gene

Domains & Families for KCNK9 Gene

Gene Families for KCNK9 Gene

Suggested Antigen Peptide Sequences for KCNK9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK9: view

Function for KCNK9 Gene

Molecular function for KCNK9 Gene

UniProtKB/Swiss-Prot Function:
pH-dependent, voltage-insensitive, background potassium channel protein.

Gene Ontology (GO) - Molecular Function for KCNK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IEA,TAS --
GO:0022841 potassium ion leak channel activity IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with KCNK9: view
genes like me logo Genes that share phenotypes with KCNK9: view

Human Phenotype Ontology for KCNK9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KCNK9 Gene

MGI Knock Outs for KCNK9:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK9

miRNA for KCNK9 Gene

miRTarBase miRNAs that target KCNK9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KCNK9 Gene

Localization for KCNK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK9 Gene COMPARTMENTS Subcellular localization image for KCNK9 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNK9: view

Pathways & Interactions for KCNK9 Gene

genes like me logo Genes that share pathways with KCNK9: view

SIGNOR curated interactions for KCNK9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KCNK9 Gene


Drugs & Compounds for KCNK9 Gene

(9) Drugs for KCNK9 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved Pharma Activator, antagonist, Target, binder 1
Doxapram Approved Pharma Target, inhibitor 7
Anandamide Pharma Antagonist, Pore Blocker 0
ruthenium red Pharma Channel blocker Non-selective Ca2+ channel blocker (N- and P-type) 0
Doxapram HCl Pharma 0

(7) Additional Compounds for KCNK9 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
Cesium chloride
DMP 543
ML 365

(5) Tocris Compounds for KCNK9 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5

(1) ApexBio Compounds for KCNK9 Gene

Compound Action Cas Number
Doxapram HCl 7081-53-0
genes like me logo Genes that share compounds with KCNK9: view

Transcripts for KCNK9 Gene

Unigene Clusters for KCNK9 Gene

Potassium channel, subfamily K, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK9 Gene

No ASD Table

Relevant External Links for KCNK9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK9 Gene

mRNA expression in normal human tissues for KCNK9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK9 Gene

This gene is overexpressed in Brain - Cerebellum (x18.8) and Brain - Cerebellar Hemisphere (x17.9).

Protein differential expression in normal tissues from HIPED for KCNK9 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK9 Gene

SOURCE GeneReport for Unigene cluster for KCNK9 Gene Hs.493037

mRNA Expression by UniProt/SwissProt for KCNK9 Gene

Tissue specificity: Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.
genes like me logo Genes that share expression patterns with KCNK9: view

Protein tissue co-expression partners for KCNK9 Gene

- Elite partner

Primer Products

Orthologs for KCNK9 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK9 35
  • 93.58 (n)
  • 95.72 (a)
KCNK9 36
  • 96 (a)
(Canis familiaris)
Mammalia KCNK9 35
  • 91.58 (n)
  • 94.39 (a)
KCNK9 36
  • 94 (a)
(Mus musculus)
Mammalia Kcnk9 35
  • 73.73 (n)
  • 73.73 (a)
Kcnk9 16
Kcnk9 36
  • 67 (a)
(Pan troglodytes)
Mammalia KCNK9 35
  • 99.91 (n)
  • 100 (a)
KCNK9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnk9 35
  • 74.82 (n)
  • 73.92 (a)
(Monodelphis domestica)
Mammalia KCNK9 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK9 36
  • 87 (a)
(Gallus gallus)
Aves LOC100859545 35
  • 83.42 (n)
  • 90.91 (a)
KCNK9 36
  • 88 (a)
(Anolis carolinensis)
Reptilia KCNK9 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk9 35
  • 79.68 (n)
  • 89.04 (a)
Str.14039 35
(Danio rerio)
Actinopterygii LOC799704 35
  • 78.52 (n)
  • 81.28 (a)
kcnk9 36
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13601 35
fruit fly
(Drosophila melanogaster)
Insecta CG9361 37
  • 51 (a)
CG9637 37
  • 57 (a)
Task7 35
  • 57.56 (n)
  • 52.67 (a)
Task6 36
  • 42 (a)
Task7 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002466 35
  • 60.22 (n)
  • 54 (a)
(Caenorhabditis elegans)
Secernentea twk-23 37
  • 55 (a)
twk-4 37
  • 44 (a)
sup-9 36
  • 50 (a)
twk-20 36
  • 36 (a)
twk-46 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for KCNK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK9 Gene

Gene Tree for KCNK9 (if available)
Gene Tree for KCNK9 (if available)

Paralogs for KCNK9 Gene

(3) SIMAP similar genes for KCNK9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK9: view

Variants for KCNK9 Gene

Sequence variations from dbSNP and Humsavar for KCNK9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_054373 Birk-Barel mental retardation dysmorphism syndrome (BIBAS)
rs2072565 -- 139,603,677(-) CTGCT(C/T)TGATG intron-variant
rs2072566 -- 139,603,631(-) CAGAG(A/T)GCAAG intron-variant
rs2072567 -- 139,603,044(-) AACCG(A/T)AGGAG intron-variant
rs2080638 -- 139,637,471(-) agcaa(A/C/G)attct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK9 Gene

Variant ID Type Subtype PubMed ID
nsv6423 CNV Loss 18451855
nsv522721 CNV Loss 19592680
nsv525709 CNV Gain 19592680
nsv6425 CNV Loss 18451855
esv2154233 CNV Deletion 18987734
esv2661944 CNV Deletion 23128226
esv2677546 CNV Deletion 23128226
nsv397287 CNV Loss 16902084
esv2737715 CNV Deletion 23290073
esv2737716 CNV Deletion 23290073
esv2737717 CNV Deletion 23290073
nsv824745 CNV Gain 20364138
esv1065914 CNV Insertion 17803354
nsv397727 CNV Loss 16902084
esv1422449 CNV Deletion 17803354
esv2737719 CNV Deletion 23290073
nsv465942 CNV Loss 19166990
nsv524756 CNV Gain 19592680
dgv1198n67 CNV Gain 20364138

Variation tolerance for KCNK9 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK9 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK9 Gene

Disorders for KCNK9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KCNK9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
birk-barel mental retardation dysmorphism syndrome
  • birk-barel syndrome
intellectual disability, birk-barel type
  • intellectual disability-hypotonia-facial dysmorphism syndrome
childhood absence epilepsy
  • absence seizure
- elite association - COSMIC cancer census association via MalaCards
Search KCNK9 in MalaCards View complete list of genes associated with diseases


  • Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM:612292]: A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. {ECO:0000269 PubMed:18678320}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KCNK9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KCNK9: view

No data available for Genatlas for KCNK9 Gene

Publications for KCNK9 Gene

  1. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 3 4 23 67
  2. TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation. (PMID: 20049674) Bandulik S. … Warth R. (Horm. Metab. Res. 2010) 3 23
  3. The two-pore domain potassium channel TASK3 functionally impacts glioma cell death. (PMID: 18217213) Meuth S.G. … Wiendl H. (J. Neurooncol. 2008) 3 23
  4. Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation. (PMID: 18824070) Meuth S.G. … Wiendl H. (Neurosci. Lett. 2008) 3 23
  5. Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture. (PMID: 17013562) Pocsai K. … RusznA!k Z. (Cell. Mol. Life Sci. 2006) 3 23

Products for KCNK9 Gene

Sources for KCNK9 Gene