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Aliases for KCNK9 Gene

Aliases for KCNK9 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 9 2 3
  • TASK3 3 4 6
  • Acid-Sensitive Potassium Channel Protein TASK-3 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 3 3 4
  • Two Pore Potassium Channel KT3.2 3 4
  • Two Pore K(+) Channel KT3.2 3 4
  • Potassium Channel, Subfamily K, Member 9 2
  • Potassium Channel Subfamily K Member 9 3
  • K2p9.1 3
  • TASK-3 3
  • KT3.2 3

External Ids for KCNK9 Gene

Previous GeneCards Identifiers for KCNK9 Gene

  • GC08M140782
  • GC08M140309
  • GC08M140595
  • GC08M140693
  • GC08M135936

Summaries for KCNK9 Gene

Entrez Gene Summary for KCNK9 Gene

  • This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for KCNK9 Gene

KCNK9 (Potassium Channel, Two Pore Domain Subfamily K, Member 9) is a Protein Coding gene. Diseases associated with KCNK9 include birk-barel mental retardation dysmorphism syndrome and fetal alcohol spectrum disorder. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and potassium channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK9 Gene

  • pH-dependent, voltage-insensitive, background potassium channel protein.

Tocris Summary for KCNK9 Gene

Gene Wiki entry for KCNK9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK9 Gene

Genomics for KCNK9 Gene

Regulatory Elements for KCNK9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK9 Gene

139,600,838 bp from pter
139,703,056 bp from pter
102,219 bases
Minus strand

Genomic View for KCNK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK9 Gene

Proteins for KCNK9 Gene

  • Protein details for KCNK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M290
    • Q540F2

    Protein attributes for KCNK9 Gene

    374 amino acids
    Molecular mass:
    42264 Da
    Quaternary structure:
    No Data Available
    • Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0
    • Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors

    Three dimensional structures from OCA and Proteopedia for KCNK9 Gene

neXtProt entry for KCNK9 Gene

Proteomics data for KCNK9 Gene at MOPED

Post-translational modifications for KCNK9 Gene

  • Glycosylation at Asn53
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK9 Gene

Domains for KCNK9 Gene

Suggested Antigen Peptide Sequences for KCNK9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK9: view

Function for KCNK9 Gene

Molecular function for KCNK9 Gene

UniProtKB/Swiss-Prot Function:
pH-dependent, voltage-insensitive, background potassium channel protein.

Gene Ontology (GO) - Molecular Function for KCNK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity --
GO:0022841 potassium ion leak channel activity IBA --
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with KCNK9: view
genes like me logo Genes that share phenotypes with KCNK9: view

Animal Models for KCNK9 Gene

MGI Knock Outs for KCNK9:

Animal Model Products

miRNA for KCNK9 Gene

miRTarBase miRNAs that target KCNK9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KCNK9 Gene

Localization for KCNK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK9 Gene COMPARTMENTS Subcellular localization image for KCNK9 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK9: view

Pathways for KCNK9 Gene

genes like me logo Genes that share pathways with KCNK9: view

Gene Ontology (GO) - Biological Process for KCNK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport NAS 11042359
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK9: view

Drugs for KCNK9 Gene

(2) Drugbank Compounds for KCNK9 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (+-)-Doxapram
309-29-5 3156 Target inhibitor approved
  • 1-Bromo-1-chloro-2,2,2-trifluoroethane
151-67-7 3562 Target binder approved

(5) Tocris Compounds for KCNK9 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(1) ApexBio Compounds for KCNK9 Gene

Compound Action Cas Number
Doxapram HCl [7081-53-0]

(3) IUPHAR Ligand for KCNK9 Gene

Ligand Type Action Affinity Pubmed IDs
ruthenium red Channel blocker None
anandamide Channel blocker None
halothane Activator None

(6) Novoseek inferred chemical compound relationships for KCNK9 Gene

Compound -log(P) Hits PubMed IDs
potassium 64.5 8
ruthenium 40.2 1
lysine 18 2
glutamate 11.8 3
alanine 7.64 2
genes like me logo Genes that share compounds with KCNK9: view

Transcripts for KCNK9 Gene

Unigene Clusters for KCNK9 Gene

Potassium channel, subfamily K, member 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK9 Gene

No ASD Table

Relevant External Links for KCNK9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK9 Gene

mRNA expression in normal human tissues for KCNK9 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK9 Gene

This gene is overexpressed in Brain - Cerebellum (18.8) and Brain - Cerebellar Hemisphere (17.9).

Protein differential expression in normal tissues for KCNK9 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK9 Gene

SOURCE GeneReport for Unigene cluster for KCNK9 Gene Hs.493037

mRNA Expression by UniProt/SwissProt for KCNK9 Gene

Tissue specificity: Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.
genes like me logo Genes that share expressions with KCNK9: view

Expression partners for KCNK9 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KCNK9 Gene

Orthologs for KCNK9 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK9 35
  • 93.58 (n)
  • 95.72 (a)
KCNK9 36
  • 96 (a)
(Canis familiaris)
Mammalia KCNK9 35
  • 91.58 (n)
  • 94.39 (a)
KCNK9 36
  • 94 (a)
(Mus musculus)
Mammalia Kcnk9 35
  • 73.73 (n)
  • 73.73 (a)
Kcnk9 16
Kcnk9 36
  • 67 (a)
(Pan troglodytes)
Mammalia KCNK9 35
  • 99.91 (n)
  • 100 (a)
KCNK9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnk9 35
  • 74.82 (n)
  • 73.92 (a)
(Monodelphis domestica)
Mammalia KCNK9 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK9 36
  • 87 (a)
(Gallus gallus)
Aves LOC100859545 35
  • 83.42 (n)
  • 90.91 (a)
KCNK9 36
  • 88 (a)
(Anolis carolinensis)
Reptilia KCNK9 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk9 35
  • 79.68 (n)
  • 89.04 (a)
Str.14039 35
(Danio rerio)
Actinopterygii LOC799704 35
  • 78.52 (n)
  • 81.28 (a)
kcnk9 36
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13601 35
fruit fly
(Drosophila melanogaster)
Insecta CG9361 37
  • 51 (a)
CG9637 37
  • 57 (a)
Task7 35
  • 57.56 (n)
  • 52.67 (a)
Task6 36
  • 42 (a)
Task7 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002466 35
  • 60.22 (n)
  • 54 (a)
(Caenorhabditis elegans)
Secernentea twk-23 37
  • 55 (a)
twk-4 37
  • 44 (a)
sup-9 36
  • 50 (a)
twk-20 36
  • 36 (a)
twk-46 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for KCNK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK9 Gene

Gene Tree for KCNK9 (if available)
Gene Tree for KCNK9 (if available)

Paralogs for KCNK9 Gene

(3) SIMAP similar genes for KCNK9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK9: view

Variants for KCNK9 Gene

Sequence variations from dbSNP and Humsavar for KCNK9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs199206 -- 139,702,048(+) AGCAA(C/T)TGAGG intron-variant
rs199207 -- 139,701,735(+) CCACC(A/G)CGTCC intron-variant
rs199208 -- 139,700,679(-) AGGGG(C/T)TGTGG intron-variant
rs199209 -- 139,700,546(+) CGCGC(A/G)CACAC intron-variant
rs199210 -- 139,700,510(+) CACAC(A/G)CGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK9 Gene

Variant ID Type Subtype PubMed ID
nsv6423 CNV Loss 18451855
nsv522721 CNV Loss 19592680
nsv525709 CNV Gain 19592680
nsv6425 CNV Loss 18451855
esv2154233 CNV Deletion 18987734
esv2661944 CNV Deletion 23128226
esv2677546 CNV Deletion 23128226
nsv397287 CNV Loss 16902084
esv2737715 CNV Deletion 23290073
esv2737716 CNV Deletion 23290073
esv2737717 CNV Deletion 23290073
nsv824745 CNV Gain 20364138
esv1065914 CNV Insertion 17803354
nsv397727 CNV Loss 16902084
esv1422449 CNV Deletion 17803354
esv2737719 CNV Deletion 23290073
nsv465942 CNV Loss 19166990
nsv524756 CNV Gain 19592680
dgv1198n67 CNV Gain 20364138

Relevant External Links for KCNK9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK9 Gene

Disorders for KCNK9 Gene

(1) OMIM Diseases for KCNK9 Gene (605874)


  • Birk-Barel mental retardation dysmorphism syndrome (BIBAS) [MIM:612292]: A syndrome characterized by mental retardation, hypotonia, hyperactivity, and facial dysmorphism. {ECO:0000269 PubMed:18678320}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for KCNK9 Gene

(3) Novoseek inferred disease relationships for KCNK9 Gene

Disease -log(P) Hits PubMed IDs
childhood absence epilepsy 71.1 1
absence seizures 52.6 5
acidosis 31.7 1

Relevant External Links for KCNK9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KCNK9: view

No data available for Genatlas for KCNK9 Gene

Publications for KCNK9 Gene

  1. Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. (PMID: 11042359) Chapman C.G. … Gloger I.S. (Brain Res. Mol. Brain Res. 2000) 3 4 23
  2. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 3 4 23
  3. TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histidine as pH sensor. (PMID: 10747866) Rajan S. … Derst C. (J. Biol. Chem. 2000) 3 4 23
  4. A TASK3 channel (KCNK9) mutation in a genetic model of absence epilepsy. (PMID: 15781965) Holter J. … Vincent P. (J. Mol. Neurosci. 2005) 3 23
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3

Products for KCNK9 Gene

Sources for KCNK9 Gene

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