Aliases for KCNK7 Gene
Aliases for KCNK7 Gene
External Ids for KCNK7 Gene
- HGNC: 6282
- Entrez Gene: 10089
- Ensembl: ENSG00000173338
- OMIM: 603940
- UniProtKB: Q9Y2U2
Previous GeneCards Identifiers for KCNK7 Gene
- GC11M067876
- GC11M067042
- GC11M065136
- GC11M065139
- GC11M065116
- GC11M065360
- GC11M061687
Summaries for KCNK7 Gene
-
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK7 Gene
KCNK7 (Potassium Two Pore Domain Channel Subfamily K Member 7) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.
UniProtKB/Swiss-Prot for KCNK7 Gene
-
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK7 Gene
Genomics for KCNK7 Gene
Regulatory Elements for KCNK7 Gene
Enhancers for KCNK7 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNK7 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNK7 gene promoter:
Regulatory Element Products
Genomic Location for KCNK7 Gene
- Chromosome:
- 11
- Start:
- 65,592,855 bp from pter
- End:
- 65,595,996 bp from pter
- Size:
- 3,142 bases
- Orientation:
- Minus strand
Genomic View for KCNK7 Gene
Genes around KCNK7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
KCNK7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK7 Gene
Proteins for KCNK7 Gene
-
Protein details for KCNK7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2U2-KCNK7_HUMAN
- Recommended name:
- Potassium channel subfamily K member 7
- Protein Accession:
- Q9Y2U2
- Q3SYI2
- Q9Y2U3
- Q9Y2U4
Protein attributes for KCNK7 Gene
- Size:
- 307 amino acids
- Molecular mass:
- 31947 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for KCNK7 Gene
Post-translational modifications for KCNK7 Gene
- Glycosylation at isoforms=2, 383
Other Protein References for KCNK7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KCNK7
- Novus Biologicals Antibodies for KCNK7
- Invitrogen Antibodies for KCNK7
- antibodies-online Antibodies for KCNK7: See all 4
- Search GeneTex for Antibodies for KCNK7
Protein Products
-
OriGene Purified Proteins for KCNK7
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNK7
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- Search GeneTex for Proteins for KCNK7
Assay Products
No data available for DME Specific Peptides for KCNK7 Gene
Domains & Families for KCNK7 Gene
Gene Families for KCNK7 Gene
Protein Domains for KCNK7 Gene
Suggested Antigen Peptide Sequences for KCNK7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y2U2UniProtKB/Swiss-Prot:
KCNK7_HUMAN :- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
- Domain:
-
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK7 Gene
Molecular function for KCNK7 Gene
- GENATLAS Biochemistry:
- potassium non voltage gated,weakly inwardly rectifying subfamily K,member 7
- UniProtKB/Swiss-Prot Function:
- Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | TAS | -- |
Phenotypes for KCNK7 Gene
- MGI mutant phenotypes for KCNK7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNK7:
Animal Models for KCNK7 Gene
- MGI Knock Outs for KCNK7:
-
- Kcnk7 tm1Dgen
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNK7 gene
-
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- Search ViGene Biosciences for KCNK7
CRISPR Products
-
OriGene CRISPR knockouts for KCNK7
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK7
- GenScript: Design CRISPR guide RNA sequences for KCNK7
miRNA for KCNK7 Gene
- miRTarBase miRNAs that target KCNK7
miRNA Products
- Search ViGene Biosciences for KCNK7
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for KCNK7
- Browse OriGene Inhibitory RNA Products For KCNK7
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK7 gene
Cell Line Products
-
Horizon Cell Lines for KCNK7
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNK7 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK7 Gene
Localization for KCNK7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK7 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNK7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Cardiac conduction | ||
| 3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK7 Gene
7 Reactome pathways for KCNK7 Gene
13 Qiagen pathways for KCNK7 Gene
Interacting Proteins for KCNK7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 10206991 |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0071805 | potassium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNK7 Gene
Drugs & Compounds for KCNK7 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK7 Gene
mRNA/cDNA for KCNK7 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNK7
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK7
- GenScript: Design CRISPR guide RNA sequences for KCNK7
miRNA Products
- Search ViGene Biosciences for KCNK7
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for KCNK7
- Browse OriGene Inhibitory RNA Products For KCNK7
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK7 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | - |
Expression for KCNK7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for KCNK7 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.7) and Skin - Sun Exposed (Lower leg) (x15.1).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KCNK7 Gene:
KCNK7SOURCE GeneReport for Unigene cluster for KCNK7 Gene:
Hs.175218Evidence on tissue expression from TISSUES for KCNK7 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for KCNK7
-
OriGene qPCR primer pairs and template standards for KCNK7
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK7 Gene
Orthologs for KCNK7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK7 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNK7 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNK7 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk7 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnk7 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNK7 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | KCNK7 35 |
|
OneToOne |
- Species where no ortholog for KCNK7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNK7 Gene
Paralogs for KCNK7 Gene
(2) SIMAP similar genes for KCNK7 Gene using alignment to 5 proteins:
Variants for KCNK7 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000860898 | -- | 65,596,315(+) | GGTGA(C/T)ATTTC | upstream-variant-2KB | |
| rs1000889063 | -- | 65,596,556(+) | CAGGT(C/G)GGGGT | upstream-variant-2KB | |
| rs1002735291 | -- | 65,596,910(+) | GAGCC(C/T)CCATG | upstream-variant-2KB | |
| rs1003063963 | -- | 65,596,167(+) | CCTTC(A/C)TGGTG | upstream-variant-2KB | |
| rs1003139102 | -- | 65,596,336(+) | TAAGA(A/G)GCCAG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1969n54 | CNV | loss | 21841781 |
| esv2761680 | CNV | gain | 21179565 |
| nsv951018 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.38;
54.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNK7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNK7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK7 Gene
Disorders for KCNK7 Gene
Relevant External Links for KCNK7
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- KCNK7
No disorders were found for KCNK7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK7 Gene
Publications for KCNK7 Gene
- Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. (PMID: 10206991) Salinas M. … Lazdunski M. (J. Biol. Chem. 1999) 2 3 4 22 64
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
- Potassium leak channels and the KCNK family of two-P-domain subunits. (PMID: 11256078) Goldstein S.A. … Zilberberg N. (Nat. Rev. Neurosci. 2001) 2 3 64
- Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
- Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells. (PMID: 15695101) Bai X. … Fyfe G.K. (J. Soc. Gynecol. Investig. 2005) 22 64
Products for KCNK7 Gene
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- Novus Biologicals Antibodies for KCNK7
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer