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Aliases for KCNK7 Gene

Aliases for KCNK7 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 7 2 3
  • Potassium Channel, Subfamily K, Member 7 2 3
  • Potassium Channel Subfamily K Member 7 3
  • Two Pore Domain K+ Channel 3
  • K2p7.1 3
  • TWIK3 3

External Ids for KCNK7 Gene

Summaries for KCNK7 Gene

Entrez Gene Summary for KCNK7 Gene

  • This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK7 Gene

KCNK7 (Potassium Channel, Two Pore Domain Subfamily K, Member 7) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK7 Gene

  • Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane

Gene Wiki entry for KCNK7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK7 Gene

Genomics for KCNK7 Gene

Genomic Location for KCNK7 Gene

Start:
65,592,855 bp from pter
End:
65,595,996 bp from pter
Size:
3,142 bases
Orientation:
Minus strand

Genomic View for KCNK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK7 Gene

Regulatory Elements for KCNK7 Gene

Proteins for KCNK7 Gene

  • Protein details for KCNK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2U2-KCNK7_HUMAN
    Recommended name:
    Potassium channel subfamily K member 7
    Protein Accession:
    Q9Y2U2
    Secondary Accessions:
    • Q3SYI2
    • Q9Y2U3
    • Q9Y2U4

    Protein attributes for KCNK7 Gene

    Size:
    307 amino acids
    Molecular mass:
    31947 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KCNK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK7 Gene

Proteomics data for KCNK7 Gene at MOPED

Post-translational modifications for KCNK7 Gene

Other Protein References for KCNK7 Gene

No data available for DME Specific Peptides for KCNK7 Gene

Domains for KCNK7 Gene

Gene Families for KCNK7 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

UniProtKB/Swiss-Prot:

KCNK7_HUMAN
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.:
    • Q9Y2U2
genes like me logo Genes that share domains with KCNK7: view

Function for KCNK7 Gene

Molecular function for KCNK7 Gene

GENATLAS Biochemistry: potassium non voltage gated,weakly inwardly rectifying subfamily K,member 7
UniProtKB/Swiss-Prot Function: Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane

Gene Ontology (GO) - Molecular Function for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS 10206991
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK7: view

Phenotypes for KCNK7 Gene

MGI mutant phenotypes for KCNK7:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with KCNK7: view

Animal Models for KCNK7 Gene

MGI Knock Outs for KCNK7:

miRNA for KCNK7 Gene

miRTarBase miRNAs that target KCNK7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNK7 Gene

Localization for KCNK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK7 Gene COMPARTMENTS Subcellular localization image for KCNK7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK7: view

Pathways for KCNK7 Gene

genes like me logo Genes that share pathways with KCNK7: view

Interacting Proteins for KCNK7 Gene

Gene Ontology (GO) - Biological Process for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 10206991
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK7: view

Compounds for KCNK7 Gene

(5) Tocris Compounds for KCNK7 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
Tetraethylammonium chloride Non-selective K+ channel blocker [56-34-8]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [33978-72-2]
genes like me logo Genes that share compounds with KCNK7: view

Transcripts for KCNK7 Gene

Unigene Clusters for KCNK7 Gene

Potassium channel, subfamily K, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for KCNK7 Gene

GeneLoc Exon Structure for
KCNK7
ECgene alternative splicing isoforms for
KCNK7

Expression for KCNK7 Gene

mRNA expression in normal human tissues for KCNK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (15.7) and Skin - Sun Exposed (Lower leg) (15.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK7 Gene

SOURCE GeneReport for Unigene cluster for KCNK7 Gene Hs.175218

genes like me logo Genes that share expressions with KCNK7: view

Orthologs for KCNK7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK7 36
  • 99.46 (n)
  • 98.7 (a)
KCNK7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK7 36
  • 84.35 (n)
  • 81.63 (a)
KCNK7 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK7 36
  • 81.87 (n)
  • 80.13 (a)
KCNK7 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk7 36
  • 80.79 (n)
  • 80.13 (a)
Kcnk7 16
Kcnk7 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK7 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk7 36
  • 78.66 (n)
  • 78.22 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNK7 37
  • 36 (a)
OneToOne
Species with no ortholog for KCNK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK7 Gene

ENSEMBL:
Gene Tree for KCNK7 (if available)
TreeFam:
Gene Tree for KCNK7 (if available)

Paralogs for KCNK7 Gene

Selected SIMAP similar genes for KCNK7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNK7: view

Variants for KCNK7 Gene

Sequence variations from dbSNP and Humsavar for KCNK7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs749112 -- 65,594,294(+) AATCA(C/T)GAAGG intron-variant
rs948685 -- 65,595,164(-) CAATA(C/G)AGTGG intron-variant
rs1784228 -- 65,594,569(+) TTTCC(A/C)AAAGA intron-variant
rs2509947 -- 65,595,779(-) CAGCG(A/G)CCTGC utr-variant-5-prime
rs3180819 -- 65,593,795(+) GCTAA(A/G)GAGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KCNK7 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
nsv897730 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
dgv1181n71 CNV Loss 21882294
dgv1182n71 CNV Loss 21882294
nsv897739 CNV Loss 21882294

Relevant External Links for KCNK7 Gene

HapMap Linkage Disequilibrium report
KCNK7

Disorders for KCNK7 Gene

No disorders were found for KCNK7 Gene.

No data available for UniProtKB/Swiss-Prot for KCNK7 Gene

Publications for KCNK7 Gene

  1. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. (PMID: 10206991) Salinas M. … Lazdunski M. (J. Biol. Chem. 1999) 2 3 4 23
  2. Potassium leak channels and the KCNK family of two-P-domain subunits. (PMID: 11256078) Goldstein S.A. … Zilberberg N. (Nat. Rev. Neurosci. 2001) 2 3
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for KCNK7 Gene

Sources for KCNK7 Gene

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