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Aliases for KCNK6 Gene

Aliases for KCNK6 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 6 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 6 2 3 5
  • Inward Rectifying Potassium Channel Protein TWIK-2 3 4
  • TWIK-Originated Similarity Sequence 3 4
  • TWIK2 3 4
  • TOSS 3 4
  • TWIK-Originated Sodium Similarity Sequence 3
  • Potassium Channel, Subfamily K, Member 6 2
  • K2P6.1 Potassium Channel 3
  • K2p6.1 3
  • TWIK-2 3
  • KCNK8 3

External Ids for KCNK6 Gene

Previous GeneCards Identifiers for KCNK6 Gene

  • GC19P039425
  • GC19P039201
  • GC19P043487
  • GC19P043505
  • GC19P043506
  • GC19P043507
  • GC19P038810
  • GC19P035258

Summaries for KCNK6 Gene

Entrez Gene Summary for KCNK6 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK6 Gene

KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include hemopericardium and gingival recession. Among its related pathways are Transmission across Chemical Synapses and Hepatic ABC Transporters. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK6 Gene

  • Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Tocris Summary for KCNK6 Gene

Gene Wiki entry for KCNK6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK6 Gene

Genomics for KCNK6 Gene

Regulatory Elements for KCNK6 Gene

Promoters for KCNK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK6 Gene

Chromosome:
19
Start:
38,319,814 bp from pter
End:
38,332,076 bp from pter
Size:
12,263 bases
Orientation:
Plus strand

Genomic View for KCNK6 Gene

Genes around KCNK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK6 Gene

Proteins for KCNK6 Gene

  • Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y257-KCNK6_HUMAN
    Recommended name:
    Potassium channel subfamily K member 6
    Protein Accession:
    Q9Y257
    Secondary Accessions:
    • Q9HB47

    Protein attributes for KCNK6 Gene

    Size:
    313 amino acids
    Molecular mass:
    33747 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

    Alternative splice isoforms for KCNK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK6 Gene

Proteomics data for KCNK6 Gene at MOPED

Post-translational modifications for KCNK6 Gene

  • Glycosylation at Asn 79 and Asn 85
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK6 Gene

Domains & Families for KCNK6 Gene

Gene Families for KCNK6 Gene

Suggested Antigen Peptide Sequences for KCNK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y257

UniProtKB/Swiss-Prot:

KCNK6_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK6: view

Function for KCNK6 Gene

Molecular function for KCNK6 Gene

GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo
UniProtKB/Swiss-Prot Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Gene Ontology (GO) - Molecular Function for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IEA,TAS --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK6: view
genes like me logo Genes that share phenotypes with KCNK6: view

Animal Models for KCNK6 Gene

MGI Knock Outs for KCNK6:

Animal Model Products

miRNA for KCNK6 Gene

miRTarBase miRNAs that target KCNK6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK6 Gene

Localization for KCNK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK6 Gene COMPARTMENTS Subcellular localization image for KCNK6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNK6: view

Pathways & Interactions for KCNK6 Gene

genes like me logo Genes that share pathways with KCNK6: view

Interacting Proteins for KCNK6 Gene

Gene Ontology (GO) - Biological Process for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006813 potassium ion transport TAS 10075682
GO:0060075 regulation of resting membrane potential IEA --
GO:0061337 cardiac conduction TAS --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK6: view

No data available for SIGNOR curated interactions for KCNK6 Gene

Drugs & Compounds for KCNK6 Gene

(2) Drugs for KCNK6 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibutilide Approved Pharma Target, inhibitor 5
Quinidine Approved Pharma Pore Blocker, Target, inhibitor 41

(5) Additional Compounds for KCNK6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
PK-THPP
1332454-07-5

(5) Tocris Compounds for KCNK6 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
genes like me logo Genes that share compounds with KCNK6: view

Transcripts for KCNK6 Gene

mRNA/cDNA for KCNK6 Gene

Unigene Clusters for KCNK6 Gene

Potassium channel, subfamily K, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK6 Gene

No ASD Table

Relevant External Links for KCNK6 Gene

GeneLoc Exon Structure for
KCNK6
ECgene alternative splicing isoforms for
KCNK6

Expression for KCNK6 Gene

mRNA expression in normal human tissues for KCNK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNK6 Gene

This gene is overexpressed in Platelet (32.6), Peripheral blood mononuclear cells (29.6), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK6 Gene



SOURCE GeneReport for Unigene cluster for KCNK6 Gene Hs.240395

mRNA Expression by UniProt/SwissProt for KCNK6 Gene

Q9Y257-KCNK6_HUMAN
Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
genes like me logo Genes that share expression patterns with KCNK6: view

Protein tissue co-expression partners for KCNK6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KCNK6 Gene

Orthologs for KCNK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK6 35
  • 86.54 (n)
  • 88.46 (a)
KCNK6 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK6 35
  • 85.73 (n)
  • 85.94 (a)
KCNK6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk6 35
  • 83.81 (n)
  • 84.98 (a)
Kcnk6 16
Kcnk6 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK6 35
  • 99.57 (n)
  • 99.36 (a)
KCNK6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk6 35
  • 83.6 (n)
  • 84.35 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK6 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK6 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK6 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk6 35
  • 57.63 (n)
  • 52.11 (a)
Str.15611 35
African clawed frog
(Xenopus laevis)
Amphibia kcnk6-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27093 35
kcnk6 35
  • 59.39 (n)
  • 54.58 (a)
kcnk6 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.19 37
  • 35 (a)
Species with no ortholog for KCNK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK6 Gene

ENSEMBL:
Gene Tree for KCNK6 (if available)
TreeFam:
Gene Tree for KCNK6 (if available)

Paralogs for KCNK6 Gene

(7) SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK6: view

Variants for KCNK6 Gene

Sequence variations from dbSNP and Humsavar for KCNK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35762773 - 38,326,719(+) GCTGA(C/G/T)TCACG reference, missense
rs34989303 - 38,327,236(+) GCCAC(A/G)TGTCC reference, missense
rs35496032 - 38,326,988(+) TCACA(A/G)GTGAG reference, missense
rs931749 -- 38,328,285(-) CTATC(A/G)CCCAG utr-variant-3-prime
rs931750 -- 38,328,111(-) TCCCT(A/G)TGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNK6 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294

Variation tolerance for KCNK6 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK6 Gene

HapMap Linkage Disequilibrium report
KCNK6
Human Gene Mutation Database (HGMD)
KCNK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene

Disorders for KCNK6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for KCNK6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemopericardium
  • haemopericardium
gingival recession
  • gingival recession nos
brachial plexus lesion
  • brachial plexus lesions
patellofemoral pain syndrome
developmental coordination disorder
  • motor skills disorders
- elite association - COSMIC cancer census association via MalaCards
Search KCNK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNK6

Genetic Association Database (GAD)
KCNK6
Human Genome Epidemiology (HuGE) Navigator
KCNK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK6
genes like me logo Genes that share disorders with KCNK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK6 Gene

Publications for KCNK6 Gene

  1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez R.A. … Yost C.S. (J. Biol. Chem. 1999) 2 3 4 67
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  3. TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel A.J. … Honore E. (J. Biol. Chem. 2000) 3 25
  4. Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. (PMID: 10393428) Gray A.T. … Yost C.S. (Cytogenet. Cell Genet. 1999) 2 3
  5. A role for two-pore Ka8_ channels in modulating Naa8_ absorption and Cla8> secretion in normal human bronchial epithelial cells. (PMID: 21964404) Zhao K.Q. … Kreindler J.L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012) 3

Products for KCNK6 Gene

Sources for KCNK6 Gene

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