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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK6 Gene

protein-coding   GIFtS: 57
GCID: GC19P038810

potassium channel, subfamily K, member 6
 Explore 4 diseases affiliated with
KCNK6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNK6    

Aliases
for KCNK6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Channel, Subfamily K, Member 61 2     TWIK-Originated Similarity Sequence2 3
TOSS2 3 5     KCNK82
TWIK22 3 5     K2P6.1 Potassium Channel2
K2p6.11 2     Potassium Channel Subfamily K Member 62
TWIK-21 2     TWIK-Originated Sodium Similarity Sequence2
Inward Rectifying Potassium Channel Protein TWIK-22 3     

External Ids:    HGNC: 62811   Entrez Gene: 94242   Ensembl: ENSG000000993377   OMIM: 6039395   UniProtKB: Q9Y2573   

Export aliases for KCNK6 gene to outside databases

Previous GC identifers: GC19P039425 GC19P039201 GC19P043487 GC19P043505 GC19P043506 GC19P043507 GC19P035258


Summaries
for KCNK6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNK6:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P
domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic
acid, and inhibited by internal acidification and volatile anaesthetics. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
Function: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical
K(+) conditions

Gene Wiki entry for KCNK6


Genomic Views
for KCNK6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK6 gene promoter:
         CRE-BP1   AhR   GATA-3   ATF-2   GATA-2   GATA-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

KCNK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P038810:  view genomic region     (about GC identifiers)

Start:
 38,810,484 bp from pter      End:
 38,819,660 bp from pter
Size:
 9,177 bases      Orientation:
 plus strand

Proteins
for KCNK6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 6  
Size: 313 amino acids; 33747 Da
Subunit: Homodimer (Potential)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine
or barium
Secondary accessions: Q9HB47
Alternative splicing: 2 isoforms:  Q9Y257-1   Q9Y257-2   

Explore the universe of human proteins at neXtProt for KCNK6: NX_Q9Y257

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y257

    • KCNK6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004814.1  
    ENSEMBL proteins: 
     ENSP00000263372  
    Reactome Protein details: Q9Y257
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: KCNK6
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    Novus Biologicals KCNK6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNK6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS10075682


    KCNK6 for ontologies           About GeneDecksing



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    Uscn Antibodies for KCNK6
    Search ThermoFisher Antibodies for KCNK6

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    Uscn ELISAs and CLIAs for KCNK6

    Protein Domains /
    Families
    for KCNK6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNK6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003280 2pore_dom_K_chnl
     IPR022306 2pore_dom_K_chnl_TASK/TWIK
     IPR005408 2pore_dom_K_chnl_TWIK
     IPR005409 2pore_dom_K_chnl_TWIK2
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry Q9Y257

    ProtoNet protein and cluster: Q9Y257

    4 Blocks protein families:
    IPB003280 Two pore domain K+ channel signature
    IPB005408 TWIK-1/TWIK-2 K+ channel family signature
    IPB005409 TWIK-2 K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Function
    for KCNK6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
    Function: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical
    K(+) conditions

         Genatlas biochemistry entry for KCNK6:
    potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNK6
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    SwitchGear 3'UTR luciferase reporter plasmid: KCNK6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK6 (see all 7)
    OriGene shRNA RFP: KCNK6
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK6 (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK6

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity TAS10075682


    KCNK6 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KCNK6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Bitter Taste Signaling0.44
    		Melatonin Signaling0.72
    		Sperm Motility0.36
    		Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Cholera Infection0.40
    		Aldosterone Signaling in Epithelial Cells0.47
    4Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    5Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    		MODY (Maturity-Onset Diabetes of Young)0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for KCNK6
        Potassium transporters- inward current
    Selected targets of ESR1
    Potassium transporters- outward current

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK6 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    4        Reactome Pathways for KCNK6
        Potassium Channels
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
    Neuronal System
    Tandem pore domain potassium channels



    KCNK6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK6

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS10075682
    GO:0007268synaptic transmission TAS--


    KCNK6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNK6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNK6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]

    2 DrugBank Compounds for KCNK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetinhibitor15926871 9257085
    Quinidine-- 56-54-2targetinhibitor18582585 10887187

    Search CenterWatch for drugs/clinical trials and news about KCNK6 

    Transcripts
    for KCNK6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNK6 gene: 
    NM_004823.1  

    Unigene Cluster for KCNK6:

    Potassium channel, subfamily K, member 6
    Hs.240395  [show with all ESTs]
    Unigene Representative Sequence: NM_004823
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263372(uc002oic.3 uc002oid.3) ENST00000588137

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: KCNK6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK6 (see all 7)
    OriGene shRNA RFP: KCNK6
    OriGene siRNA: KCNK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNK6
    Clone
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    GenScript: all cDNA clones in your preferred vector: KCNK6 (NM_004823)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNK6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK6

    Additional cDNA sequence: 

    AF117708.1 AF134149.1 AF281302.1 AF281303.1 AK022344.1 AK222545.1 AK315653.1 BC004367.1 
    EU978937.1 

    4 DOTS entries:

    DT.75200295  DT.99931649  DT.121443116  DT.95100529 

    24/50 AceView cDNA sequences (see all 50):

    AF117708 AV725208 AI493766 BC004367 NM_004823 AK022344 AI861948 AA029298 
    AF281302 AA604914 CR614493 BX370291 BU164630 BE858776 AA029837 W74496 
    BQ709141 BE735881 BI906214 AF134149 AU122142 BX400294 AI377055 AF281303 

    GeneLoc Exon Structure


    Expression
    for KCNK6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACACCATTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNK6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See KCNK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNK6

    SOURCE GeneReport for Unigene cluster: Hs.240395

    UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
    Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest
    expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung,
    liver, kidney and thymus. Lowest expression detected in brain

        SABiosciences Custom PCR Arrays for KCNK6
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    In Situ
    Assay Products:     
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    Orthologs
    for KCNK6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNK6 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcnk61 , 5 potassium inwardly-rectifying channel, subfamily K, member 6 less1, 5 83.81(n)1
    84.98(a)1    		   7 (16.94 cM)5
    521501  NM_001033525.31  NP_001028697.21 
     292219285 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNK66
    KCNK126
    		 --
    		 56(a)
    22(a)
    		 1 ↔ 1
    possible ortholog
    		 LGf(1892986-1895635)
    1(254990917-254991252)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kcnk6-prov2 potassium channel, subfamily K, member 6 (TWIK-2) 75.03(n)    BC047247.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.270932 Danio rerio cDNA clone IMAGE3815424, partial cds 75(n)    BC058054.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y39B6A.193   -- 35(a)   V(19056869-19063586)   --


    ENSEMBL Gene Tree for KCNK6 (if available)
    TreeFam Gene Tree for KCNK6 (if available) 

    Paralogs
    for KCNK6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNK6 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK22  KCNK182  
    KCNK172  KCNK102  KCNK72  KCNK42  KCNK132  KCNK12  
    7 SIMAP similar genes for KCNK6 using alignment to 3 protein entries:     KCNK6_HUMAN (see all proteins):
    KCNK1    KCNK16    KCNK7    KCNK2    KCNK10    KCNK17
    KCNK4

    KCNK6 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNK6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 NCBI SNPs in KCNK6 are shown (see all 214)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1861259631,2
    		--38808498(+) TACAGG/TCATGA 4 -- int1 us2k10--------
    rs1172341391,2
    		F,--38808504(+) CATGAA/GACACC 4 -- int1 us2k11Minor allele frequency- G:0.21NA 120
    rs1176244911,2
    		F,--38808505(+) ATGAAA/CCACCG 4 -- us2k1 int11Minor allele frequency- C:0.20NA 120
    rs779127941,2
    		C,F,--38808512(+) ACCGCA/GCCCAG 4 -- int1 us2k11Minor allele frequency- G:0.23NA 120
    rs1909863101,2
    		--38808518(+) CCCAGC/TCTTAT 4 -- int1 us2k10--------
    rs1119587191,2
    		--38808533(+) ATATAT/CTTAAT 4 -- us2k1 int13Minor allele frequency- C:0.12CSA NA EA 242
    rs1125398861,2
    		C,--38808573(+) GATCAC/TGCCTG 4 -- us2k1 int10--------
    rs1834816661,2
    		--38808702(+) GTGGCA/GGGCAT 1 -- int10--------
    rs1436253681,2
    		--38808861(+) AAAAA-/GCAAGTT 1 -- int10--------
    rs1884241851,2
    		--38808935(+) TTTTTA/GTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KCNK6 (38810484 - 38819660 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNK6: --
    Human Gene Mutation Database (HGMD): KCNK6

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    Disorders / Diseases
    for KCNK6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNK6 for disorders           About GeneDecksing

    OMIM gene information: 603939    OMIM disorders: --

    4 diseases for KCNK6:    About MalaCards
    brachial plexus lesion    root caries    hemopericardium    duodenitis

    3 diseases from the University of Copenhagen DISEASES database for KCNK6:
    Developmental coordination disorder     Brachial plexus lesion     Hemopericardium
    Human Genome Epidemiology (HuGE) Navigator: KCNK6 (1 document)

    Export disorders for KCNK6 gene to outside databases

    Publications
    for KCNK6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNK6 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with KCNK6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TWIK-2, an inactivating 2P domain K+ channel. (PubMed id 10887187)1, 2, 7 Patel A.J....Honore E. (2000)
    2. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PubMed id 10075682)1, 2, 3 Chavez R.A.... Yost C.S. (1999)
    3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. (PubMed id 10393428)1, 3 Gray A.T....Yost C.S. (1999)
    6. Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. (PubMed id 10359073)1, 2 Pountney D.J.... Coetzee W.A. (1999)
    7. A role for two-pore K^+ channels in modulating Na^+ ab sorption and Cl^- secretion in normal human bronchial epithelial cells. (PubMed id 21964404)1 Zhao K.Q....Kreindler J.L. (2012)
    8. A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
    9. Genetic modifiers of the severity of sickle cell anem ia identified through a genome-wide association study. (PubMed id 20029952)1 Sebastiani P....Steinberg M.H. (2010)
    10. Selective block of IKs plays a significant role in MA P triangulation induced by IKr block in isolated rabbit heart. (PubMed id 18582585)7 GuAcrard N.C....Dumotier B.M. (2008)

    External Searches for KCNK6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KCNK6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9424 HGNC: 6281 AceView: KCNK6 Ensembl:ENSG00000099337 euGenes: HUgn9424
    ECgene: KCNK6 H-InvDB: KCNK6

    Other Databases showing KCNK6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNK6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNK6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNK6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNK6 gene:
    Search GeneIP for patents involving KCNK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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