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Aliases for KCNK6 Gene

Aliases for KCNK6 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 6 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 6 2 3
  • Inward Rectifying Potassium Channel Protein TWIK-2 3 4
  • TWIK-Originated Similarity Sequence 3 4
  • TWIK2 3 4
  • TOSS 3 4
  • TWIK-Originated Sodium Similarity Sequence 3
  • Potassium Channel, Subfamily K, Member 6 2
  • Potassium Channel Subfamily K Member 6 3
  • K2P6.1 Potassium Channel 3
  • K2p6.1 3
  • TWIK-2 3
  • KCNK8 3

External Ids for KCNK6 Gene

Previous GeneCards Identifiers for KCNK6 Gene

  • GC19P039425
  • GC19P039201
  • GC19P043487
  • GC19P043505
  • GC19P043506
  • GC19P043507
  • GC19P038810
  • GC19P035258

Summaries for KCNK6 Gene

Entrez Gene Summary for KCNK6 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK6 Gene

KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include Hemopericardium and Brachial Plexus Lesion. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.

UniProtKB/Swiss-Prot for KCNK6 Gene

  • Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Tocris Summary for KCNK6 Gene

Gene Wiki entry for KCNK6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK6 Gene

Genomics for KCNK6 Gene

Regulatory Elements for KCNK6 Gene

Enhancers for KCNK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038373 1.2 ENCODE 16.2 +55.6 55579 3.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 CATSPERG ZNF793 KCNK6 ZNF781 ENSG00000267152 ZNF607 FBXO17 FAM98C YIF1B PPP1R14A
GH19G038269 1.5 Ensembl ENCODE dbSUPER 11.9 -49.1 -49110 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF592 SMARCA4 ZSCAN16 GLIS1 C19orf33 CATSPERG ZNF607 ZNF793 LOC100631378 KCNK6 DPF1 YIF1B ENSG00000269688 GGN
GH19G038262 1.4 ENCODE dbSUPER 11.9 -53.9 -53949 6.7 HDGF FOXA2 PKNOX1 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF573 ZNF607 ZNF793 ZNF569 C19orf33 ZNF570 CATSPERG LOC100631378 PPP1R14A LOC284412
GH19G038276 1.4 Ensembl ENCODE dbSUPER 11.9 -41.9 -41920 2.6 PKNOX1 KLF17 SIN3A RAD21 ZNF121 GATA2 SCRT2 ZNF143 FOS CREM C19orf33 ZNF793 ZNF781 ENSG00000267152 ZNF607 PPP1R14A SPINT2 YIF1B KCNK6 CATSPERG
GH19G038297 1.3 Ensembl ENCODE dbSUPER 12.5 -21.1 -21082 1.8 GTF2F1 KLF1 ESRRA NFIB ZIC2 ZNF335 ZNF23 CTBP1 ZFHX2 GATA3 KCNK6 CATSPERG PPP1R14A SPINT2 C19orf33 ENSG00000200209
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNK6 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109271 386 1201 ZNF133 SIN3A GLIS2 ZNF366 ZNF391 EGR2 SP3 GATAD2B ZNF623 MTA1

Genomic Location for KCNK6 Gene

Chromosome:
19
Start:
38,319,814 bp from pter
End:
38,332,076 bp from pter
Size:
12,263 bases
Orientation:
Plus strand

Genomic View for KCNK6 Gene

Genes around KCNK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK6 Gene

Proteins for KCNK6 Gene

  • Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y257-KCNK6_HUMAN
    Recommended name:
    Potassium channel subfamily K member 6
    Protein Accession:
    Q9Y257
    Secondary Accessions:
    • Q9HB47

    Protein attributes for KCNK6 Gene

    Size:
    313 amino acids
    Molecular mass:
    33747 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

    Alternative splice isoforms for KCNK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK6 Gene

Post-translational modifications for KCNK6 Gene

  • Glycosylation at isoforms=79 and posLast=8585
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK6 Gene

No data available for DME Specific Peptides for KCNK6 Gene

Domains & Families for KCNK6 Gene

Gene Families for KCNK6 Gene

Suggested Antigen Peptide Sequences for KCNK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y257

UniProtKB/Swiss-Prot:

KCNK6_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK6: view

Function for KCNK6 Gene

Molecular function for KCNK6 Gene

GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo
UniProtKB/Swiss-Prot Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Gene Ontology (GO) - Molecular Function for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 10075682
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS --
genes like me logo Genes that share ontologies with KCNK6: view
genes like me logo Genes that share phenotypes with KCNK6: view

Animal Models for KCNK6 Gene

MGI Knock Outs for KCNK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK6

CRISPR Products

miRNA for KCNK6 Gene

miRTarBase miRNAs that target KCNK6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK6 Gene

Localization for KCNK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 10075682
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK6: view

Pathways & Interactions for KCNK6 Gene

genes like me logo Genes that share pathways with KCNK6: view

Gene Ontology (GO) - Biological Process for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10075682
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK6: view

No data available for SIGNOR curated interactions for KCNK6 Gene

Drugs & Compounds for KCNK6 Gene

(5) Drugs for KCNK6 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibutilide Approved Pharma Target, inhibitor 5
Quinidine Approved Pharma Pore Blocker, Target, inhibitor 45
BL 1249 Pharma Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener 0
DMP 543 Pharma K+ channel blocker and potent ACh release enhancer 0
ML365 Pharma Potent and selective TASK-1 channel blocker 0

(2) Additional Compounds for KCNK6 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK6 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3
genes like me logo Genes that share compounds with KCNK6: view

Transcripts for KCNK6 Gene

Unigene Clusters for KCNK6 Gene

Potassium channel, subfamily K, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK6 Gene

No ASD Table

Relevant External Links for KCNK6 Gene

GeneLoc Exon Structure for
KCNK6
ECgene alternative splicing isoforms for
KCNK6

Expression for KCNK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNK6 Gene

This gene is overexpressed in Platelet (32.6), Peripheral blood mononuclear cells (29.6), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK6 Gene



Protein tissue co-expression partners for KCNK6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK6 Gene:

KCNK6

SOURCE GeneReport for Unigene cluster for KCNK6 Gene:

Hs.240395

mRNA Expression by UniProt/SwissProt for KCNK6 Gene:

Q9Y257-KCNK6_HUMAN
Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Evidence on tissue expression from TISSUES for KCNK6 Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with KCNK6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK6 Gene

Orthologs for KCNK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK6 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia KCNK6 34 35
  • 86.54 (n)
dog
(Canis familiaris)
Mammalia KCNK6 34 35
  • 85.73 (n)
mouse
(Mus musculus)
Mammalia Kcnk6 34 16 35
  • 83.81 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909725 34
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNK6 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK6 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK6 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk6 34
  • 57.63 (n)
Str.15611 34
African clawed frog
(Xenopus laevis)
Amphibia kcnk6-prov 34
zebrafish
(Danio rerio)
Actinopterygii kcnk6 34 35
  • 59.39 (n)
Dr.27093 34
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.19 36
  • 35 (a)
Species where no ortholog for KCNK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK6 Gene

ENSEMBL:
Gene Tree for KCNK6 (if available)
TreeFam:
Gene Tree for KCNK6 (if available)

Paralogs for KCNK6 Gene

Paralogs for KCNK6 Gene

(7) SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK6: view

Variants for KCNK6 Gene

Sequence variations from dbSNP and Humsavar for KCNK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000308085 -- 38,322,165(+) AGACG(G/T)CATAG intron-variant
rs1000372110 -- 38,323,995(+) AAAAC(A/G)CTGTT intron-variant
rs1000387631 -- 38,317,897(+) ATTTA(A/C)TTAAT intron-variant, upstream-variant-2KB
rs1000488188 -- 38,324,309(+) ATGAG(A/G)GTTGG intron-variant
rs1000835862 -- 38,319,235(+) GGGAC(A/T)ACAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK6 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for KCNK6 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK6 Gene

Human Gene Mutation Database (HGMD)
KCNK6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene

Disorders for KCNK6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KCNK6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hemopericardium
  • haemopericardium
brachial plexus lesion
  • brachial plexus lesions
gingival recession
  • gingival recession nos
patellofemoral pain syndrome
developmental coordination disorder
  • motor skills disorders
- elite association - COSMIC cancer census association via MalaCards
Search KCNK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNK6

Genetic Association Database (GAD)
KCNK6
Human Genome Epidemiology (HuGE) Navigator
KCNK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK6
genes like me logo Genes that share disorders with KCNK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK6 Gene

Publications for KCNK6 Gene

  1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez R.A. … Yost C.S. (J. Biol. Chem. 1999) 2 3 4 64
  2. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PMID: 20029952) Sebastiani P. … Steinberg M.H. (Am. J. Hematol. 2010) 3 46 64
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel A.J. … Honore E. (J. Biol. Chem. 2000) 3 4 64

Products for KCNK6 Gene

Sources for KCNK6 Gene

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