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KCNK6 Gene

protein-coding   GIFtS: 62
GCID: GC19P038810

Potassium Channel, Subfamily K, Member 6

  See KCNK6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel, Subfamily K, Member 61 2     KCNK82
TOSS2 3 5     TWIK-22
TWIK22 3 5     K2P6.1 Potassium Channel2
Inward Rectifying Potassium Channel Protein TWIK-22 3     Potassium Channel Subfamily K Member 62
TWIK-Originated Similarity Sequence2 3     TWIK-Originated Sodium Similarity Sequence2
K2p6.12     

External Ids:    HGNC: 62811   Entrez Gene: 94242   Ensembl: ENSG000000993377   OMIM: 6039395   UniProtKB: Q9Y2573   

Export aliases for KCNK6 gene to outside databases

Previous GC identifers: GC19P039425 GC19P039201 GC19P043487 GC19P043505 GC19P043506 GC19P043507 GC19P035258


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNK6 Gene:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming
P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by
arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. (provided by RefSeq, Jul
2008)

GeneCards Summary for KCNK6 Gene:
KCNK6 (potassium channel, subfamily K, member 6) is a protein-coding gene. Diseases associated with KCNK6 include hemopericardium, and brachial plexus lesion. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
Function: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in
symmetrical K(+) conditions

Gene Wiki entry for KCNK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK6 gene promoter:
         CRE-BP1   AhR   GATA-3   ATF-2   GATA-2   GATA-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK6 promoter sequence
   Search Chromatin IP Primers for KCNK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

KCNK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P038810:  view genomic region     (about GC identifiers)

Start:
38,810,484 bp from pter      End:
38,819,660 bp from pter
Size:
9,177 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 6  
Size: 313 amino acids; 33747 Da
Subunit: Homodimer (Potential)
Miscellaneous: Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine,
quinidine or barium
Secondary accessions: Q9HB47
Alternative splicing: 2 isoforms:  Q9Y257-1   Q9Y257-2   

Explore the universe of human proteins at neXtProt for KCNK6: NX_Q9Y257

Explore proteomics data for KCNK6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn79, Asn85
  • Modification sites at PhosphoSitePlus

  • See KCNK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004814.1  
    ENSEMBL proteins: 
     ENSP00000263372  
    Reactome Protein details: Q9Y257

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P6.1
    Two-P potassium channels

    5 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR005408 2pore_dom_K_chnl_TWIK
     IPR005409 2pore_dom_K_chnl_TWIK2
     IPR013099 2pore_dom_K_chnl_dom
     IPR003092 2pore_dom_K_chnl_TASK

    Graphical View of Domain Structure for InterPro Entry Q9Y257

    ProtoNet protein and cluster: Q9Y257

    4 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB005408 TWIK-1/TWIK-2 K+ channel family signature
    IPB005409 TWIK-2 K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Find genes that share domains with KCNK6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNK6_HUMAN, Q9Y257
    Function: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in
    symmetrical K(+) conditions

         Genatlas biochemistry entry for KCNK6:
    potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and
    embryo

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity TAS10075682
    GO:0005267potassium channel activity ----
         
    Find genes that share ontologies with KCNK6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcnk6):
     cardiovascular system  muscle 

    Find genes that share phenotypes with KCNK6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KCNK6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNK6_HUMAN, Q9Y257: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS10075682
    GO:0016020membrane ----

    Find genes that share ontologies with KCNK6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNK6 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)0.00
    Potassium transporters outward current0.41
    Tandem pore domain potassium channels0.00
    2Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41


    Find genes that share SuperPaths with KCNK6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNK6 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    1 Reactome Pathway for KCNK6
        Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNK6
    Interactions:

        Search GeneGlobe Interaction Network for KCNK6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KCNK6 (ENSP000002633724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP9-1ENSP000003814884STRING: ENSP00000381488
    BMPERENSP000002971614STRING: ENSP00000297161
    CRIM1ENSP000002805274STRING: ENSP00000280527
    --ENSP000003966644STRING: ENSP00000396664
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003073regulation of systemic arterial blood pressure ----
    GO:0003085negative regulation of systemic arterial blood pressure IEA--
    GO:0006813potassium ion transport TAS10075682
    GO:0007268synaptic transmission TAS--
    GO:0060075regulation of resting membrane potential IEA--

    Find genes that share ontologies with KCNK6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for KCNK6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    2 DrugBank Compounds for KCNK6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetinhibitor15926871 9257085
    Quinidine-- 56-54-2targetinhibitor18582585 10887187



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNK6 gene: 
    NM_004823.1  

    Unigene Cluster for KCNK6:

    Potassium channel, subfamily K, member 6
    Hs.240395  [show with all ESTs]
    Unigene Representative Sequence: NM_004823
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263372(uc002oic.3 uc002oid.3) ENST00000588137
    miRNA
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    Additional mRNA sequence: 

    AF117708.1 AF134149.1 AF281302.1 AF281303.1 AK022344.1 AK222545.1 AK315653.1 BC004367.1 
    EU978937.1 

    4 DOTS entries:

    DT.75200295  DT.99931649  DT.121443116  DT.95100529 

    Selected AceView cDNA sequences (see all 50):

    AV725208 AA604914 AF117708 AF281302 BC004367 AI861948 NM_004823 AI493766 
    AK022344 BE858776 CR614493 AA029837 BX370291 W74496 AA029298 BU164630 
    AF134149 AA644054 AU122142 BI906214 BQ709141 AI377055 BX400294 AF281303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACCATTGT
    KCNK6 Expression
    About this image


    KCNK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    KCNK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.240395

    UniProtKB/Swiss-Prot: KCNK6_HUMAN, Q9Y257
    Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest
    expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes,
    lung, liver, kidney and thymus. Lowest expression detected in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNK6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk61 , 5 potassium inwardly-rectifying channel, subfamily K, more1, 5 83.81(n)1
    84.98(a)1
      7 (16.94 cM)5
    521501  NM_001033525.31  NP_001028697.21 
     292219285 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK66
    potassium channel, subfamily K, member 6
    56(a)
    1 ↔ 1
    LGf(1892986-1899517)
    African clawed frog
    (Xenopus laevis)
    Amphibia kcnk6-prov2 potassium channel, subfamily K, member 6 (TWIK-2) 75.03(n)    BC047247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.270932 Danio rerio cDNA clone IMAGE3815424, partial cds 75(n)    BC058054.1 


    ENSEMBL Gene Tree for KCNK6 (if available)
    TreeFam Gene Tree for KCNK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNK6 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK22  KCNK102  
    KCNK72  KCNK172  KCNK42  KCNK132  KCNK12  
    7 SIMAP similar genes for KCNK6 using alignment to 3 protein entries:     KCNK6_HUMAN (see all proteins):
    KCNK1    KCNK16    KCNK7    KCNK2    KCNK10    KCNK17
    KCNK4

    Find genes that share paralogs with KCNK6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNK6 (see all 265)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823167781,2
    --35256140(+) GTTTCA/GCCATG 1 -- int10--------
    rs1421107901,2
    C--35256198(+) TTGGCC/GTCCCA 1 -- int10--------
    rs1834816661,2
    --38808702(+) GTGGCA/GGGCAT 1 -- int10--------
    rs1436253681,2
    --38808861(+) AAAAA-/GCAAGTT 1 -- int10--------
    rs1884241851,2
    --38808935(+) TTTTTA/GTTTTT 1 -- int10--------
    rs1920587211,2
    --38809048(+) CCTCCC/TGAGTA 1 -- int10--------
    rs1453689231,2
    C--38809070(+) AGACGC/TATGCC 1 -- int10--------
    rs116681121,2
    C,H--38809253(+) tggcaG/Taatgt 1 -- int16Minor allele frequency- T:0.00NS EA NA 422
    rs713549961,2
    C,F--38809359(+) ATCTGC/ACAGCT 1 -- int15Minor allele frequency- A:0.06NA WA EA 362
    rs1829758041,2
    --38809398(+) GAGCTA/GAGCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for KCNK6 (38810484 - 38819660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KCNK6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911658CNV Loss21882294
    nsv833822CNV Loss17160897

    Human Gene Mutation Database (HGMD): KCNK6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNK6
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603939    OMIM disorders: --

    4 diseases for KCNK6:    
    About MalaCards
    hemopericardium    brachial plexus lesion    developmental coordination disorder    sickle cell anemia

    3 diseases from the University of Copenhagen DISEASES database for KCNK6:
    Brachial plexus lesion     Developmental coordination disorder     Hemopericardium

    Find genes that share disorders with KCNK6           About GenesLikeMe

    Genetic Association Database (GAD): KCNK6
    Human Genome Epidemiology (HuGE) Navigator: KCNK6 (1 document)

    Export disorders for KCNK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNK6 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with KCNK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TWIK-2, an inactivating 2P domain K+ channel. (PubMed id 10887187)1, 2, 7 Patel A.J....Honore E. (J. Biol. Chem. 2000)
    2. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PubMed id 10075682)1, 2, 3 Chavez R.A.... Yost C.S. (J. Biol. Chem. 1999)
    3. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PubMed id 20029952)1, 4 Sebastiani P....Steinberg M.H. (Am. J. Hematol. 2010)
    4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. (PubMed id 10393428)1, 3 Gray A.T....Yost C.S. (Cytogenet. Cell Genet. 1999)
    7. Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. (PubMed id 10359073)1, 2 Pountney D.J.... Coetzee W.A. (FEBS Lett. 1999)
    8. A role for two-pore Ka8_ channels in modulating Naa8_ absorption and Cla8> secretion in normal human bronchial epithelial cells. (PubMed id 21964404)1 Zhao K.Q....Kreindler J.L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012)
    9. A catalogue of putative HIV-1 protease host cell substrates. (PubMed id 22944692)1 Impens F....Gevaert K. (Biol. Chem. 2012)
    10. Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. (PubMed id 18582585)7 GuAcrard N.C....Dumotier B.M. (J Pharmacol Toxicol Methods 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9424 HGNC: 6281 AceView: KCNK6 Ensembl:ENSG00000099337 euGenes: HUgn9424
    ECgene: KCNK6 H-InvDB: KCNK6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNK6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNK6 gene:
    Search GeneIP for patents involving KCNK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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