Aliases for KCNK6 Gene
Aliases for KCNK6 Gene
External Ids for KCNK6 Gene
- HGNC: 6281
- Entrez Gene: 9424
- Ensembl: ENSG00000099337
- OMIM: 603939
- UniProtKB: Q9Y257
Previous GeneCards Identifiers for KCNK6 Gene
- GC19P039425
- GC19P039201
- GC19P043487
- GC19P043505
- GC19P043506
- GC19P043507
- GC19P038810
- GC19P035258
Summaries for KCNK6 Gene
-
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK6 Gene
KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include Hemopericardium and Brachial Plexus Lesion. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.
UniProtKB/Swiss-Prot for KCNK6 Gene
-
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK6 Gene
Genomics for KCNK6 Gene
Regulatory Elements for KCNK6 Gene
Enhancers for KCNK6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNK6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNK6 gene promoter:
Regulatory Element Products
Genomic Location for KCNK6 Gene
- Chromosome:
- 19
- Start:
- 38,319,814 bp from pter
- End:
- 38,332,076 bp from pter
- Size:
- 12,263 bases
- Orientation:
- Plus strand
Genomic View for KCNK6 Gene
Genes around KCNK6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
KCNK6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK6 Gene
Proteins for KCNK6 Gene
-
Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y257-KCNK6_HUMAN
- Recommended name:
- Potassium channel subfamily K member 6
- Protein Accession:
- Q9Y257
- Q9HB47
Protein attributes for KCNK6 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 33747 Da
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.
Protein Expression for KCNK6 Gene
Post-translational modifications for KCNK6 Gene
Other Protein References for KCNK6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KCNK6
- Invitrogen Antibodies for KCNK6
- antibodies-online Antibodies for KCNK6: See all 28
- GeneTex KCNK6 antibody for KCNK6
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNK6
Protein Products
-
OriGene Purified Proteins for KCNK6
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNK6
- Origene Custom Protein Services for KCNK6
- Search GeneTex for Proteins for KCNK6
Assay Products
No data available for DME Specific Peptides for KCNK6 Gene
Domains & Families for KCNK6 Gene
Gene Families for KCNK6 Gene
Protein Domains for KCNK6 Gene
Suggested Antigen Peptide Sequences for KCNK6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y257UniProtKB/Swiss-Prot:
KCNK6_HUMAN :- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
- Domain:
-
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK6 Gene
Molecular function for KCNK6 Gene
- GENATLAS Biochemistry:
- potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo
- UniProtKB/Swiss-Prot Function:
- Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005242 | inward rectifier potassium channel activity | TAS | 10075682 |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | TAS | -- |
Phenotypes for KCNK6 Gene
- MGI mutant phenotypes for KCNK6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNK6:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Effect on mitosis
- Decreased IL-8 secretion
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
Animal Models for KCNK6 Gene
- MGI Knock Outs for KCNK6:
-
- Kcnk6 tm1Tigm
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNK6
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK6 gene
- Search ViGene Biosciences for KCNK6
CRISPR Products
-
OriGene CRISPR knockouts for KCNK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK6
- GenScript: Design CRISPR guide RNA sequences for KCNK6
miRNA for KCNK6 Gene
- miRTarBase miRNAs that target KCNK6
-
- hsa-mir-218-5p (MIRT440405)
- hsa-mir-6516-5p (MIRT461054)
- hsa-mir-455-3p (MIRT461055)
- hsa-mir-3190-3p (MIRT461056)
- hsa-mir-6851-5p (MIRT461057)
- hsa-mir-3689d (MIRT461058)
- hsa-mir-6499-3p (MIRT461059)
- hsa-mir-6134 (MIRT461060)
- hsa-mir-6840-3p (MIRT461061)
- hsa-mir-665 (MIRT461062)
- hsa-mir-4459 (MIRT461063)
- hsa-mir-495-5p (MIRT461064)
- hsa-mir-550b-2-5p (MIRT519052)
- hsa-mir-328-3p (MIRT519053)
- hsa-mir-6807-5p (MIRT519054)
- hsa-mir-550a-5p (MIRT519055)
- hsa-mir-550a-3-5p (MIRT519056)
- hsa-mir-1271-3p (MIRT519057)
- hsa-mir-6851-3p (MIRT519058)
- hsa-mir-6775-3p (MIRT519059)
- hsa-mir-1291 (MIRT519060)
- hsa-mir-661 (MIRT519061)
- hsa-mir-3116 (MIRT519062)
- hsa-mir-1254 (MIRT519063)
- hsa-mir-6889-3p (MIRT519064)
- hsa-mir-4252 (MIRT519065)
- hsa-mir-6832-3p (MIRT519066)
- hsa-mir-619-5p (MIRT519067)
- hsa-mir-7151-3p (MIRT519068)
- hsa-mir-5095 (MIRT519069)
- hsa-mir-3119 (MIRT519070)
- hsa-mir-4663 (MIRT519071)
- hsa-mir-6823-3p (MIRT519072)
- hsa-mir-2114-3p (MIRT519073)
- hsa-mir-4537 (MIRT519074)
- hsa-mir-6751-3p (MIRT519075)
- hsa-mir-1199-5p (MIRT519076)
- hsa-mir-4438 (MIRT519077)
- hsa-mir-6504-3p (MIRT519078)
- hsa-mir-498 (MIRT626787)
- hsa-mir-4772-3p (MIRT626788)
- hsa-mir-6890-3p (MIRT626789)
- hsa-mir-1306-5p (MIRT626790)
- hsa-mir-6809-3p (MIRT635809)
- hsa-mir-6833-3p (MIRT635810)
- hsa-mir-4768-5p (MIRT635811)
- hsa-mir-4753-3p (MIRT635812)
- hsa-mir-6873-3p (MIRT635813)
- hsa-mir-130b-5p (MIRT635814)
- hsa-mir-7110-3p (MIRT635815)
- hsa-mir-6817-3p (MIRT635816)
- hsa-mir-4668-5p (MIRT649600)
- hsa-mir-3149 (MIRT649601)
- hsa-mir-297 (MIRT649602)
- hsa-mir-675-3p (MIRT649603)
- hsa-mir-567 (MIRT649604)
- hsa-mir-3977 (MIRT685566)
- hsa-mir-3157-5p (MIRT685567)
- hsa-mir-636 (MIRT685568)
- hsa-mir-5589-5p (MIRT685569)
- hsa-mir-4731-5p (MIRT685570)
- hsa-mir-6778-3p (MIRT685571)
- hsa-mir-186-3p (MIRT685572)
- hsa-mir-520h (MIRT685573)
- hsa-mir-520g-3p (MIRT685574)
- hsa-mir-512-3p (MIRT685575)
- hsa-mir-576-3p (MIRT685576)
- hsa-mir-5683 (MIRT685577)
- hsa-mir-520e (MIRT685578)
- hsa-mir-520d-3p (MIRT685579)
- hsa-mir-520c-3p (MIRT685580)
- hsa-mir-520b (MIRT685581)
- hsa-mir-520a-3p (MIRT685582)
- hsa-mir-373-3p (MIRT685583)
- hsa-mir-372-3p (MIRT685584)
- hsa-mir-302e (MIRT685585)
- hsa-mir-302d-3p (MIRT685586)
- hsa-mir-302c-3p (MIRT685587)
- hsa-mir-302b-3p (MIRT685588)
- hsa-mir-302a-3p (MIRT685589)
- hsa-mir-93-5p (MIRT685590)
- hsa-mir-526b-3p (MIRT685591)
- hsa-mir-519d-3p (MIRT685592)
- hsa-mir-20b-5p (MIRT685593)
- hsa-mir-20a-5p (MIRT685594)
- hsa-mir-17-5p (MIRT685595)
- hsa-mir-106b-5p (MIRT685596)
- hsa-mir-106a-5p (MIRT685597)
- hsa-mir-6878-3p (MIRT696034)
- hsa-mir-6749-3p (MIRT696035)
- hsa-mir-601 (MIRT696036)
- hsa-mir-6744-3p (MIRT696037)
- hsa-mir-4757-5p (MIRT696038)
- hsa-mir-3663-5p (MIRT696039)
- hsa-mir-7152-3p (MIRT696040)
- hsa-mir-3922-3p (MIRT696041)
- hsa-mir-3176 (MIRT696042)
- hsa-mir-2116-3p (MIRT696043)
- hsa-mir-8073 (MIRT696044)
- hsa-mir-221-5p (MIRT696045)
- hsa-mir-5582-3p (MIRT696046)
- hsa-mir-548f-3p (MIRT696047)
- hsa-mir-548e-3p (MIRT696048)
- hsa-mir-548az-3p (MIRT696049)
- hsa-mir-548ar-3p (MIRT696050)
- hsa-mir-548a-3p (MIRT696051)
miRNA Products
- Search ViGene Biosciences for KCNK6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNK6
- Browse OriGene Inhibitory RNA Products For KCNK6
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK6 gene
Clone Products
-
OriGene ORF clones in human for KCNK6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for KCNK6
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNK6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNK6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK6 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK6 Gene
Localization for KCNK6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | TAS | 10075682 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNK6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Cardiac conduction | ||
| 3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK6 Gene
7 Reactome pathways for KCNK6 Gene
13 Qiagen pathways for KCNK6 Gene
Interacting Proteins for KCNK6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003085 | negative regulation of systemic arterial blood pressure | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 10075682 |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNK6 Gene
Drugs & Compounds for KCNK6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ibutilide | Approved | Pharma | Target, inhibitor | 5 | ||
| Quinidine | Approved | Pharma | Pore Blocker, Target, inhibitor | 45 | ||
| BL 1249 | Pharma | Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener | 0 | |||
| DMP 543 | Pharma | K+ channel blocker and potent ACh release enhancer | 0 | |||
| ML365 | Pharma | Potent and selective TASK-1 channel blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK6 Gene
mRNA/cDNA for KCNK6 Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNK6
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK6
- GenScript: Design CRISPR guide RNA sequences for KCNK6
miRNA Products
- Search ViGene Biosciences for KCNK6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNK6
- Browse OriGene Inhibitory RNA Products For KCNK6
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK6 gene
Clone Products
-
OriGene ORF clones in human for KCNK6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for KCNK6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Liver (Hepatobiliary System)
This gene is overexpressed in Platelet (32.6), Peripheral blood mononuclear cells (29.6), and Testis (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KCNK6 Gene:
KCNK6SOURCE GeneReport for Unigene cluster for KCNK6 Gene:
Hs.240395mRNA Expression by UniProt/SwissProt for KCNK6 Gene:
Q9Y257-KCNK6_HUMAN
Tissue specificity:
Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Evidence on tissue expression from TISSUES for KCNK6 Gene
- Nervous system(4.3)
- Pancreas(4.1)
Primer Products
-
OriGene qPCR primer pairs for KCNK6
-
OriGene qPCR primer pairs and template standards for KCNK6
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK6 Gene
Orthologs for KCNK6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNK6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNK6 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100909725 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNK6 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNK6 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KCNK6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnk6 34 |
|
||
| Str.15611 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | kcnk6-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kcnk6 34 35 |
|
||
| Dr.27093 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | Y39B6A.19 36 |
|
|
- Species where no ortholog for KCNK6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KCNK6 Gene
Paralogs for KCNK6 Gene
(7) SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:
Variants for KCNK6 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000308085 | -- | 38,322,165(+) | AGACG(G/T)CATAG | intron-variant | |
| rs1000372110 | -- | 38,323,995(+) | AAAAC(A/G)CTGTT | intron-variant | |
| rs1000387631 | -- | 38,317,897(+) | ATTTA(A/C)TTAAT | intron-variant, upstream-variant-2KB | |
| rs1000488188 | -- | 38,324,309(+) | ATGAG(A/G)GTTGG | intron-variant | |
| rs1000835862 | -- | 38,319,235(+) | GGGAC(A/T)ACAGG | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.47;
77.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNK6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene
Disorders for KCNK6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemopericardium |
|
|
| brachial plexus lesion |
|
|
| gingival recession |
|
|
| patellofemoral pain syndrome |
|
|
| developmental coordination disorder |
|
|
Search KCNK6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNK6
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK6 Gene
Publications for KCNK6 Gene
- TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez R.A. … Yost C.S. (J. Biol. Chem. 1999) 2 3 4 64
- Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PMID: 20029952) Sebastiani P. … Steinberg M.H. (Am. J. Hematol. 2010) 3 46 64
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel A.J. … Honore E. (J. Biol. Chem. 2000) 3 4 64
Products for KCNK6 Gene
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for KCNK6
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for KCNK6
- Novus Biologicals proteins and lysates for KCNK6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for KCNK6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for KCNK6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KCNK6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KCNK6 gene
- Search ViGene Biosciences for KCNK6
- Santa Cruz Biotechnology (SCBT) Antibodies for KCNK6
- Search Santa Cruz Biotechnology (SCBT) for KCNK6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KCNK6
- Horizon Cell Lines for KCNK6
- Cyagen custom Knockout/knockin (KOKI) mouse models for KCNK6
- VectorBuilder custom plasmid, inducible vectors for KCNK6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KCNK6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer