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Aliases for KCNK6 Gene

Aliases for KCNK6 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 6 2 3
  • TWIK2 3 4 6
  • TOSS 3 4 6
  • Inward Rectifying Potassium Channel Protein TWIK-2 3 4
  • TWIK-Originated Similarity Sequence 3 4
  • TWIK-Originated Sodium Similarity Sequence 3
  • Potassium Channel, Subfamily K, Member 6 2
  • Potassium Channel Subfamily K Member 6 3
  • K2P6.1 Potassium Channel 3
  • K2p6.1 3
  • TWIK-2 3
  • KCNK8 3

External Ids for KCNK6 Gene

Previous GeneCards Identifiers for KCNK6 Gene

  • GC19P039425
  • GC19P039201
  • GC19P043487
  • GC19P043505
  • GC19P043506
  • GC19P043507
  • GC19P038810
  • GC19P035258

Summaries for KCNK6 Gene

Entrez Gene Summary for KCNK6 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK6 Gene

KCNK6 (Potassium Channel, Two Pore Domain Subfamily K, Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include developmental coordination disorder and brachial plexus lesion. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK6 Gene

  • Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions

Tocris Summary for KCNK6 Gene

Gene Wiki entry for KCNK6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK6 Gene

Genomics for KCNK6 Gene

Regulatory Elements for KCNK6 Gene

Genomic Location for KCNK6 Gene

38,319,831 bp from pter
38,333,427 bp from pter
13,597 bases
Plus strand

Genomic View for KCNK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK6 Gene

Proteins for KCNK6 Gene

  • Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 6
    Protein Accession:
    Secondary Accessions:
    • Q9HB47

    Protein attributes for KCNK6 Gene

    313 amino acids
    Molecular mass:
    33747 Da
    Quaternary structure:
    • Homodimer.
    • Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium

    Alternative splice isoforms for KCNK6 Gene


neXtProt entry for KCNK6 Gene

Proteomics data for KCNK6 Gene at MOPED

Post-translational modifications for KCNK6 Gene

  • Glycosylation at Asn79 and Asn85
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK6 Gene

Domains for KCNK6 Gene

Gene Families for KCNK6 Gene

  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P

Suggested Antigen Peptide Sequences for KCNK6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y257
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK6: view

Function for KCNK6 Gene

Molecular function for KCNK6 Gene

GENATLAS Biochemistry: potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo
UniProtKB/Swiss-Prot Function: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions

Gene Ontology (GO) - Molecular Function for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 10075682
GO:0005267 potassium channel activity --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK6: view

Phenotypes for KCNK6 Gene

genes like me logo Genes that share phenotypes with KCNK6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK6 Gene

Localization for KCNK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK6 Gene COMPARTMENTS Subcellular localization image for KCNK6 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 10075682
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNK6: view

Pathways for KCNK6 Gene

genes like me logo Genes that share pathways with KCNK6: view

Interacting Proteins for KCNK6 Gene

Gene Ontology (GO) - Biological Process for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006813 potassium ion transport TAS 10075682
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
genes like me logo Genes that share ontologies with KCNK6: view

Compounds for KCNK6 Gene

(5) Tocris Compounds for KCNK6 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(2) Drugbank Compounds for KCNK6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Ibutilida [INN-Spanish]
122647-32-9 target inhibitor
56-54-2 target inhibitor
genes like me logo Genes that share compounds with KCNK6: view

Transcripts for KCNK6 Gene

Unigene Clusters for KCNK6 Gene

Potassium channel, subfamily K, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK6 Gene

No ASD Table

Relevant External Links for KCNK6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK6 Gene

mRNA expression in normal human tissues for KCNK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK6 Gene

SOURCE GeneReport for Unigene cluster for KCNK6 Gene Hs.240395

mRNA Expression by UniProt/SwissProt for KCNK6 Gene

Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain
genes like me logo Genes that share expressions with KCNK6: view

No data available for mRNA differential expression in normal tissues for KCNK6 Gene

Orthologs for KCNK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNK6 35
  • 99.57 (n)
  • 99.36 (a)
KCNK6 36
  • 99 (a)
(Bos Taurus)
Mammalia KCNK6 35
  • 86.54 (n)
  • 88.46 (a)
KCNK6 36
  • 88 (a)
(Canis familiaris)
Mammalia KCNK6 35
  • 85.73 (n)
  • 85.94 (a)
KCNK6 36
  • 86 (a)
(Mus musculus)
Mammalia Kcnk6 35
  • 83.81 (n)
  • 84.98 (a)
Kcnk6 16
Kcnk6 36
  • 85 (a)
(Monodelphis domestica)
Mammalia KCNK6 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK6 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Kcnk6 35
  • 83.6 (n)
  • 84.35 (a)
(Anolis carolinensis)
Reptilia KCNK6 36
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia kcnk6-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk6 35
  • 57.63 (n)
  • 52.11 (a)
Str.15611 35
(Danio rerio)
Actinopterygii Dr.27093 35
kcnk6 35
  • 59.39 (n)
  • 54.58 (a)
kcnk6 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea Y39B6A.19 37
  • 35 (a)
Species with no ortholog for KCNK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK6 Gene

Gene Tree for KCNK6 (if available)
Gene Tree for KCNK6 (if available)

Paralogs for KCNK6 Gene

Selected SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK6: view

Variants for KCNK6 Gene

Sequence variations from dbSNP and Humsavar for KCNK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs931749 -- 38,328,285(-) CTATC(A/G)CCCAG utr-variant-3-prime, intron-variant
rs931750 -- 38,328,111(-) TCCCT(A/G)TGCTT utr-variant-3-prime, intron-variant
rs3745951 -- 38,326,846(+) ATCTT(C/T)GCCCA synonymous-codon, reference
rs3745952 -- 38,327,659(+) TGTGT(C/T)TCTCT utr-variant-3-prime, intron-variant
rs3786881 -- 38,328,078(+) GCACA(A/G)GCAGA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK6 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV Loss 17160897
nsv911658 CNV Loss 21882294

Relevant External Links for KCNK6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene

Disorders for KCNK6 Gene

(3) University of Copenhagen DISEASES for KCNK6 Gene

Relevant External Links for KCNK6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KCNK6: view

No data available for UniProtKB/Swiss-Prot for KCNK6 Gene

Publications for KCNK6 Gene

  1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez R.A. … Yost C.S. (J. Biol. Chem. 1999) 2 3 4
  2. TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel A.J. … Honore E. (J. Biol. Chem. 2000) 3 4 25
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  5. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PMID: 20029952) Sebastiani P. … Steinberg M.H. (Am. J. Hematol. 2010) 3 48

Products for KCNK6 Gene

Sources for KCNK6 Gene

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