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Aliases for KCNK5 Gene

Aliases for KCNK5 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 5 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 5 2 3 5
  • Acid-Sensitive Potassium Channel Protein TASK-2 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 2 3 4
  • TASK2 3 4
  • Potassium Channel, Subfamily K, Member 1 (TASK-2) 3
  • Potassium Channel, Subfamily, Member 5 (KCNK5) 3
  • Potassium Channel, Subfamily K, Member 5 2
  • TWIK-Related Acid-Sensitive K+ Channel 2 3
  • K2P5.1 Potassium Channel 3
  • K2p5.1 3
  • KCNK5b 3
  • TASK-2 3

External Ids for KCNK5 Gene

Previous GeneCards Identifiers for KCNK5 Gene

  • GC06M039158
  • GC06M039203
  • GC06M039264
  • GC06M038875
  • GC06M039208
  • GC06M039242
  • GC06M039292
  • GC06M039246
  • GC06M039352

Summaries for KCNK5 Gene

Entrez Gene Summary for KCNK5 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK5 Gene

KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) is a Protein Coding gene. Diseases associated with KCNK5 include Balkan Nephropathy. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK5 Gene

  • pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.

Tocris Summary for KCNK5 Gene

Gene Wiki entry for KCNK5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK5 Gene

Genomics for KCNK5 Gene

Regulatory Elements for KCNK5 Gene

Enhancers for KCNK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNK5 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK5 Gene

Chromosome:
6
Start:
39,188,971 bp from pter
End:
39,229,475 bp from pter
Size:
40,505 bases
Orientation:
Minus strand

Genomic View for KCNK5 Gene

Genes around KCNK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK5 Gene

Proteins for KCNK5 Gene

  • Protein details for KCNK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95279-KCNK5_HUMAN
    Recommended name:
    Potassium channel subfamily K member 5
    Protein Accession:
    O95279
    Secondary Accessions:
    • B2RAQ6
    • B5TJL2
    • Q5VV76

    Protein attributes for KCNK5 Gene

    Size:
    499 amino acids
    Molecular mass:
    55130 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    Miscellaneous:
    • Inhibited by quinine, quinidine and external acidification.

neXtProt entry for KCNK5 Gene

Proteomics data for KCNK5 Gene at MOPED

Post-translational modifications for KCNK5 Gene

  • Glycosylation at Asn 77
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KCNK5

No data available for DME Specific Peptides for KCNK5 Gene

Domains & Families for KCNK5 Gene

Gene Families for KCNK5 Gene

Suggested Antigen Peptide Sequences for KCNK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95279

UniProtKB/Swiss-Prot:

KCNK5_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK5: view

Function for KCNK5 Gene

Molecular function for KCNK5 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 5,mainly expressed in cortical tubules and collecting ducts of kidneys
UniProtKB/Swiss-Prot Function:
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.

Gene Ontology (GO) - Molecular Function for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity TAS 9812978
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK5: view
genes like me logo Genes that share phenotypes with KCNK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK5

miRNA for KCNK5 Gene

miRTarBase miRNAs that target KCNK5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK5 Gene

Localization for KCNK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK5 Gene COMPARTMENTS Subcellular localization image for KCNK5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for KCNK5 Gene

Pathways & Interactions for KCNK5 Gene

genes like me logo Genes that share pathways with KCNK5: view

Interacting Proteins for KCNK5 Gene

Gene Ontology (GO) - Biological Process for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 9812978
GO:0030322 stabilization of membrane potential IBA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK5: view

No data available for SIGNOR curated interactions for KCNK5 Gene

Drugs & Compounds for KCNK5 Gene

(5) Drugs for KCNK5 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxapram HCl Pharma 0

(5) Additional Compounds for KCNK5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
PK-THPP
1332454-07-5

(5) Tocris Compounds for KCNK5 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5

(1) ApexBio Compounds for KCNK5 Gene

Compound Action Cas Number
Doxapram HCl 7081-53-0
genes like me logo Genes that share compounds with KCNK5: view

Transcripts for KCNK5 Gene

mRNA/cDNA for KCNK5 Gene

Unigene Clusters for KCNK5 Gene

Potassium channel, subfamily K, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK5 Gene

No ASD Table

Relevant External Links for KCNK5 Gene

GeneLoc Exon Structure for
KCNK5
ECgene alternative splicing isoforms for
KCNK5

Expression for KCNK5 Gene

mRNA expression in normal human tissues for KCNK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK5 Gene

This gene is overexpressed in Kidney - Cortex (x9.8) and Skin - Sun Exposed (Lower leg) (x5.1).

SOURCE GeneReport for Unigene cluster for KCNK5 Gene Hs.444448

mRNA Expression by UniProt/SwissProt for KCNK5 Gene

O95279-KCNK5_HUMAN
Tissue specificity: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
genes like me logo Genes that share expression patterns with KCNK5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNK5 Gene

Orthologs for KCNK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK5 35
  • 87.53 (n)
  • 89.74 (a)
KCNK5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK5 35
  • 88.11 (n)
  • 89.98 (a)
KCNK5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk5 35
  • 84.77 (n)
  • 89.18 (a)
Kcnk5 16
Kcnk5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK5 35
  • 99 (n)
  • 99.8 (a)
KCNK5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk5 35
  • 84.17 (n)
  • 87.58 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK5 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK5 35
  • 68.42 (n)
  • 73.74 (a)
KCNK5 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK5 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk5 35
  • 68.45 (n)
  • 68.37 (a)
Str.16771 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7279 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17953 35
kcnk5a 35
  • 57.42 (n)
  • 53.99 (a)
kcnk5a 36
  • 50 (a)
OneToMany
kcnk5b 36
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1682 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
CSA.6929 36
  • 29 (a)
ManyToMany
Species with no ortholog for KCNK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK5 Gene

ENSEMBL:
Gene Tree for KCNK5 (if available)
TreeFam:
Gene Tree for KCNK5 (if available)

Paralogs for KCNK5 Gene

(1) SIMAP similar genes for KCNK5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK5: view

Variants for KCNK5 Gene

Sequence variations from dbSNP and Humsavar for KCNK5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9462487 - 39,190,997(+) GGAGG(G/T)GAACT reference, missense
rs1055069 -- 39,189,254(+) GCCTT(A/C/G/T)TGCCC utr-variant-3-prime
rs1078270 -- 39,210,302(+) CTTGG(C/T)CCTCT intron-variant
rs1078570 -- 39,211,055(-) GGGAC(A/G)GCTAA intron-variant
rs4989623 -- 39,230,641(+) acaca(C/G)acaca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK5 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897

Variation tolerance for KCNK5 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK5 Gene

Human Gene Mutation Database (HGMD)
KCNK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK5 Gene

Disorders for KCNK5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
balkan nephropathy
  • balkan endemic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search KCNK5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNK5

Genetic Association Database (GAD)
KCNK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK5
genes like me logo Genes that share disorders with KCNK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK5 Gene

Publications for KCNK5 Gene

  1. Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. (PMID: 9812978) Reyes R. … Lazdunski M. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  3. Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum. (PMID: 15197476) RusznA!k Z. … SzA1cs G. (Cell. Mol. Life Sci. 2004) 3 23
  4. The two-pore domain K2 P channel TASK2 drives human NK-cell proliferation and cytolytic function. (PMID: 26140335) Schulte-Mecklenbeck A. … Gross C.C. (Eur. J. Immunol. 2015) 3
  5. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. (PMID: 24564958) St Pourcain B. … Smith G.D. (Mol Autism 2014) 3

Products for KCNK5 Gene

Sources for KCNK5 Gene

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