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Aliases for KCNK5 Gene

Aliases for KCNK5 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 5 2 3
  • TASK2 3 4 6
  • Acid-Sensitive Potassium Channel Protein TASK-2 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 2 3 4
  • Potassium Channel, Subfamily K, Member 1 (TASK-2) 3
  • Potassium Channel, Subfamily, Member 5 (KCNK5) 3
  • Potassium Channel, Subfamily K, Member 5 2
  • TWIK-Related Acid-Sensitive K+ Channel 2 3
  • Potassium Channel Subfamily K Member 5 3
  • K2P5.1 Potassium Channel 3
  • K2p5.1 3
  • KCNK5b 3
  • TASK-2 3

External Ids for KCNK5 Gene

Previous GeneCards Identifiers for KCNK5 Gene

  • GC06M039158
  • GC06M039203
  • GC06M039264
  • GC06M038875
  • GC06M039208
  • GC06M039242
  • GC06M039292

Summaries for KCNK5 Gene

Entrez Gene Summary for KCNK5 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK5 Gene

KCNK5 (Potassium Channel, Two Pore Domain Subfamily K, Member 5) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK5 Gene

  • pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations

Tocris Summary for KCNK5 Gene

Gene Wiki entry for KCNK5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK5 Gene

Genomics for KCNK5 Gene

Regulatory Elements for KCNK5 Gene

Genomic Location for KCNK5 Gene

Start:
39,188,971 bp from pter
End:
39,229,475 bp from pter
Size:
40,505 bases
Orientation:
Minus strand

Genomic View for KCNK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK5 Gene

Proteins for KCNK5 Gene

  • Protein details for KCNK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95279-KCNK5_HUMAN
    Recommended name:
    Potassium channel subfamily K member 5
    Protein Accession:
    O95279
    Secondary Accessions:
    • B2RAQ6
    • B5TJL2
    • Q5VV76

    Protein attributes for KCNK5 Gene

    Size:
    499 amino acids
    Molecular mass:
    55130 Da
    Quaternary structure:
    • Homodimer; disulfide-linked
    Miscellaneous:
    • Inhibited by quinine, quinidine and external acidification

neXtProt entry for KCNK5 Gene

Proteomics data for KCNK5 Gene at MOPED

Post-translational modifications for KCNK5 Gene

  • Glycosylation at Asn77
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK5 Gene

Domains for KCNK5 Gene

Gene Families for KCNK5 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

Suggested Antigen Peptide Sequences for KCNK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95279

UniProtKB/Swiss-Prot:

KCNK5_HUMAN :
  • O95279
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK5: view

Function for KCNK5 Gene

Molecular function for KCNK5 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel inwardly rectifying,subfamily K,member 5,mainly expressed in cortical tubules and collecting ducts of kidneys
UniProtKB/Swiss-Prot Function: pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations

Gene Ontology (GO) - Molecular Function for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS 9812978
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK5: view
genes like me logo Genes that share phenotypes with KCNK5: view

miRNA for KCNK5 Gene

miRTarBase miRNAs that target KCNK5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNK5 Gene

Localization for KCNK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK5 Gene COMPARTMENTS Subcellular localization image for KCNK5 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9812978
genes like me logo Genes that share ontologies with KCNK5: view

Pathways for KCNK5 Gene

genes like me logo Genes that share pathways with KCNK5: view

Pathways by source for KCNK5 Gene

Interacting Proteins for KCNK5 Gene

Gene Ontology (GO) - Biological Process for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 9812978
GO:0007588 excretion TAS 9812978
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK5: view

Compounds for KCNK5 Gene

(5) Tocris Compounds for KCNK5 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(4) Novoseek inferred chemical compound relationships for KCNK5 Gene

Compound -log(P) Hits PubMed IDs
quinidine 60.3 1
4-aminopyridine 57.4 1
quinine 56 1
potassium 49.2 1
genes like me logo Genes that share compounds with KCNK5: view

Transcripts for KCNK5 Gene

mRNA/cDNA for KCNK5 Gene

Unigene Clusters for KCNK5 Gene

Potassium channel, subfamily K, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK5 Gene

No ASD Table

Relevant External Links for KCNK5 Gene

GeneLoc Exon Structure for
KCNK5
ECgene alternative splicing isoforms for
KCNK5

Expression for KCNK5 Gene

mRNA expression in normal human tissues for KCNK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK5 Gene

This gene is overexpressed in Kidney - Cortex (9.8) and Skin - Sun Exposed (Lower leg) (5.1).

SOURCE GeneReport for Unigene cluster for KCNK5 Gene Hs.444448

mRNA Expression by UniProt/SwissProt for KCNK5 Gene

O95279-KCNK5_HUMAN
Tissue specificity: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli
genes like me logo Genes that share expressions with KCNK5: view

No data available for Protein expression for KCNK5 Gene

Orthologs for KCNK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK5 35
  • 99 (n)
  • 99.8 (a)
KCNK5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK5 35
  • 87.53 (n)
  • 89.74 (a)
KCNK5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK5 35
  • 88.11 (n)
  • 89.98 (a)
KCNK5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk5 35
  • 84.77 (n)
  • 89.18 (a)
Kcnk5 16
Kcnk5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK5 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK5 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk5 35
  • 84.17 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves KCNK5 35
  • 68.42 (n)
  • 73.74 (a)
KCNK5 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK5 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7279 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk5 35
  • 68.45 (n)
  • 68.37 (a)
Str.16771 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17953 35
kcnk5a 35
  • 57.42 (n)
  • 53.99 (a)
kcnk5a 36
  • 50 (a)
OneToMany
kcnk5b 36
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1682 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
CSA.6929 36
  • 29 (a)
ManyToMany
Species with no ortholog for KCNK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK5 Gene

ENSEMBL:
Gene Tree for KCNK5 (if available)
TreeFam:
Gene Tree for KCNK5 (if available)

Paralogs for KCNK5 Gene

Selected SIMAP similar genes for KCNK5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK5: view

Variants for KCNK5 Gene

Sequence variations from dbSNP and Humsavar for KCNK5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs733701 -- 39,204,086(+) CTGGA(C/T)GAAAG intron-variant
rs746443 -- 39,193,470(-) ACCCA(C/G)CACCC intron-variant
rs751272 -- 39,230,631(+) ACACA(C/G)ACACA upstream-variant-2KB
rs751933 -- 39,196,345(-) GGAAC(A/G)TGTTT intron-variant, upstream-variant-2KB
rs751934 -- 39,196,300(-) CTCGG(A/G)GTAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK5 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897

Relevant External Links for KCNK5 Gene

HapMap Linkage Disequilibrium report
KCNK5
Human Gene Mutation Database (HGMD)
KCNK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK5 Gene

Disorders for KCNK5 Gene

Relevant External Links for KCNK5

Genetic Association Database (GAD)
KCNK5
genes like me logo Genes that share disorders with KCNK5: view

No data available for UniProtKB/Swiss-Prot for KCNK5 Gene

Publications for KCNK5 Gene

  1. Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. (PMID: 9812978) Reyes R. … Lazdunski M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity. (PMID: 12851074) Niemeyer M.I. … Sepulveda F.V. (Mol. Membr. Biol. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3

Products for KCNK5 Gene

Sources for KCNK5 Gene

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