Aliases for KCNK4 Gene
Aliases for KCNK4 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 4 2 3 5
- TWIK-Related Arachidonic Acid-Stimulated Potassium Channel Protein 3 4
- Potassium Channel, Two Pore Domain Subfamily K, Member 4 2 3
- Potassium Channel, Subfamily K, Member 4 2 3
- Two Pore Potassium Channel KT4.1 3 4
- Two Pore K(+) Channel KT4.1 3 4
- TRAAK 3 4
External Ids for KCNK4 Gene
- HGNC: 6279
- Entrez Gene: 50801
- Ensembl: ENSG00000182450
- OMIM: 605720
- UniProtKB: Q9NYG8
Previous GeneCards Identifiers for KCNK4 Gene
- GC11P066574
- GC11P065740
- GC11P064309
- GC11P063834
- GC11P063815
- GC11P064058
- GC11P060386
Summaries for KCNK4 Gene
-
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
GeneCards Summary for KCNK4 Gene
KCNK4 (Potassium Two Pore Domain Channel Subfamily K Member 4) is a Protein Coding gene. Diseases associated with KCNK4 include Dentin Sensitivity. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK10.
UniProtKB/Swiss-Prot for KCNK4 Gene
-
Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK4 Gene
Genomics for KCNK4 Gene
Regulatory Elements for KCNK4 Gene
Enhancers for KCNK4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNK4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNK4 gene promoter:
Regulatory Element Products
Genomic Location for KCNK4 Gene
- Chromosome:
- 11
- Start:
- 64,291,302 bp from pter
- End:
- 64,300,031 bp from pter
- Size:
- 8,730 bases
- Orientation:
- Plus strand
Genomic View for KCNK4 Gene
Genes around KCNK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
KCNK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK4 Gene
Proteins for KCNK4 Gene
-
Protein details for KCNK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYG8-KCNK4_HUMAN
- Recommended name:
- Potassium channel subfamily K member 4
- Protein Accession:
- Q9NYG8
- B5TJL1
- Q96T94
Protein attributes for KCNK4 Gene
- Size:
- 393 amino acids
- Molecular mass:
- 42704 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Three dimensional structures from OCA and Proteopedia for KCNK4 Gene
Protein Expression for KCNK4 Gene
Post-translational modifications for KCNK4 Gene
- N-glycosylated.
- Glycosylation at isoforms=278 and isoforms=282
- Modification sites at PhosphoSitePlus
Other Protein References for KCNK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for KCNK4
- Novus Biologicals Antibodies for KCNK4
-
Abcam antibodies for KCNK4
- Invitrogen Antibodies for KCNK4
- antibodies-online Antibodies for KCNK4: See all 26
- GeneTex KCNK4 antibody for KCNK4
Protein Products
-
OriGene Purified Proteins for KCNK4
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNK4
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- Search GeneTex for Proteins for KCNK4
Assay Products
No data available for DME Specific Peptides for KCNK4 Gene
Domains & Families for KCNK4 Gene
Gene Families for KCNK4 Gene
Protein Domains for KCNK4 Gene
Suggested Antigen Peptide Sequences for KCNK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYG8UniProtKB/Swiss-Prot:
KCNK4_HUMAN :- Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
- Domain:
-
- Channel opening is brought about by a conformation change that involves buckling of the second transmembrane helix and affects the position and orientation of the fourth transmembrane helix.
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK4 Gene
Molecular function for KCNK4 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by arachidonic acid.
- UniProtKB/Swiss-Prot Function:
- Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | TAS,IDA | 22282805 |
| GO:0097604 | temperature-gated cation channel activity | ISS | -- |
| GO:0098782 | mechanically-gated potassium channel activity | IDA | 22282805 |
Phenotypes for KCNK4 Gene
- MGI mutant phenotypes for KCNK4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNK4:
Animal Models for KCNK4 Gene
- MGI Knock Outs for KCNK4:
-
- Kcnk4 tm1Lzd
Animal Model Products
-
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ViGene Biosciences lentiviral particle packaged cDNA for KCNK4 gene
-
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CRISPR Products
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OriGene CRISPR knockouts for KCNK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK4
- GenScript: Design CRISPR guide RNA sequences for KCNK4
miRNA for KCNK4 Gene
- miRTarBase miRNAs that target KCNK4
miRNA Products
- Search ViGene Biosciences for KCNK4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNK4
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Cell Line Products
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Horizon Cell Lines for KCNK4
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK4 Gene
Localization for KCNK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK4 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0034705 | potassium channel complex | IDA | 22282805 |
Pathways & Interactions for KCNK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Cardiac conduction | ||
| 3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK4 Gene
7 Reactome pathways for KCNK4 Gene
13 Qiagen pathways for KCNK4 Gene
Interacting Proteins for KCNK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 10767409 |
| GO:0007613 | memory | IEA | -- |
| GO:0019233 | sensory perception of pain | ISS | -- |
No data available for SIGNOR curated interactions for KCNK4 Gene
Drugs & Compounds for KCNK4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Riluzole | Approved, Investigational | Pharma | Activator, blocker | Sodium channel protein inhibitor | 65 | |
| arachidonic acid | Experimental | Nutra | Activator | 30 | ||
| BL 1249 | Pharma | Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener | 0 | |||
| DMP 543 | Pharma | K+ channel blocker and potent ACh release enhancer | 0 | |||
| ML365 | Pharma | Potent and selective TASK-1 channel blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK4 Gene
mRNA/cDNA for KCNK4 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (75) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK4
- GenScript: Design CRISPR guide RNA sequences for KCNK4
miRNA Products
- Search ViGene Biosciences for KCNK4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNK4
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-
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Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - |
| ExUns: | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: |
Expression for KCNK4 Gene
mRNA differential expression in normal tissues according to GTEx for KCNK4 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Amygdala (x6.1), Brain - Hippocampus (x6.1), Brain - Cortex (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Caudate (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Putamen (basal ganglia) (x4.7).
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KCNK4 Gene:
KCNK4SOURCE GeneReport for Unigene cluster for KCNK4 Gene:
Hs.647233Evidence on tissue expression from TISSUES for KCNK4 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for KCNK4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK4 Gene
Orthologs for KCNK4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNK4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNK4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnk4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNK4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnk4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | BX465841.1 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6929 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for KCNK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNK4 Gene
Paralogs for KCNK4 Gene
(6) SIMAP similar genes for KCNK4 Gene using alignment to 5 proteins:
Variants for KCNK4 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000079532 | -- | 64,293,184(+) | GCGAC(A/C)AGGAG | intron-variant, nc-transcript-variant, reference, missense | |
| rs1000451236 | -- | 64,293,623(+) | TGAGA(C/T)GGAGT | intron-variant | |
| rs1000676012 | -- | 64,292,303(+) | ACCCC(C/G)GCCCC | intron-variant | |
| rs1000811738 | -- | 64,292,137(+) | GCGGG(A/G)CGGCG | intron-variant | |
| rs1001526080 | -- | 64,294,355(+) | TCTAC(C/T)AAAAA | intron-variant |
Residual Variation Intolerance Score:
51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.94;
83.93% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNK4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNK4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK4 Gene
Disorders for KCNK4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dentin sensitivity |
|
|
Search KCNK4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNK4
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK4 Gene
Publications for KCNK4 Gene
- Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two- pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. (PMID: 12191490) Ozaita A. … Vega-Saenz de Miera E. (Brain Res. Mol. Brain Res. 2002) 3 4 22 64
- Cloning and expression of human TRAAK, a polyunsaturated fatty acids- activated and mechano-sensitive K(+) channel. (PMID: 10767409) Lesage F. … Lazdunski M. (FEBS Lett. 2000) 2 3 4 64
- Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels. (PMID: 25500157) Lolicato M. … Minor D.L. Jr. (Neuron 2014) 3 4 64
- Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. (PMID: 23341632) Brohawn S.G. … MacKinnon R. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
- Crystal structure of the human K2P TRAAK, a lipid- and mechano- sensitive K+ ion channel. (PMID: 22282805) Brohawn S.G. … MacKinnon R. (Science 2012) 3 4 64
Products for KCNK4 Gene
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- Taconic Biosciences Mouse Models for KCNK4
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- VectorBuilder custom plasmid, inducible vectors for KCNK4
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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