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KCNK4 Gene

protein-coding   GIFtS: 60
GCID: GC11P064058

Potassium Channel, Subfamily K, Member 4

  See KCNK4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Potassium Channel, Subfamily K, Member 41 2     K2p4.12
TRAAK2 3 5     TRAAK12
Two Pore K(+) Channel KT4.12 3     K2P4.1 Potassium Channel2
Two Pore Potassium Channel KT4.12 3     Potassium Channel Subfamily K Member 42
TWIK-Related Arachidonic Acid-Stimulated Potassium Channel Protein2 3     Two Pore K+ Channel KT4.12

External Ids:    HGNC: 62791   Entrez Gene: 508012   Ensembl: ENSG000001824507   OMIM: 6057205   UniProtKB: Q9NYG83   
ORGUL members:         

Export aliases for KCNK4 gene to outside databases

Previous GC identifers: GC11P066574 GC11P065740 GC11P064309 GC11P063834 GC11P063815 GC11P060386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNK4 Gene:
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle
contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the
superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein
homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and
is stimulated by membrane stretch and polyunsaturated fatty acids. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNK4 Gene:
KCNK4 (potassium channel, subfamily K, member 4) is a protein-coding gene. Diseases associated with KCNK4 include dentin sensitivity. GO annotations related to this gene include voltage-gated ion channel activity and potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNK4_HUMAN, Q9NYG8
Function: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is
reversed at high external K(+) concentrations (By similarity)

Gene Wiki entry for KCNK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK4 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK4 promoter sequence
   Search Chromatin IP Primers for KCNK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

KCNK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064058:  view genomic region     (about GC identifiers)

Start:
64,058,774 bp from pter      End:
64,067,503 bp from pter
Size:
8,730 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNK4_HUMAN, Q9NYG8 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 4  
Size: 393 amino acids; 42704 Da
Subunit: Homodimer; disulfide-linked
Sequence caution: Sequence=AAF64062.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for KCNK4:
3UM7 (3D)        4I9W (3D)    
Secondary accessions: B5TJL1 Q96T94
Alternative splicing: 2 isoforms:  Q9NYG8-1   Q9NYG8-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for KCNK4: NX_Q9NYG8

Explore proteomics data for KCNK4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn78, Asn82
  • Modification sites at PhosphoSitePlus

  • See KCNK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_201567.1  
    ENSEMBL proteins: 
     ENSP00000446454   ENSP00000402797   ENSP00000441460   ENSP00000378033   ENSP00000444948  
    Reactome Protein details: Q9NYG8

    KCNK4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P4.1
    Two-P potassium channels

    3 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR008074 2pore_dom_K_chnl_TRAAK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYG8

    ProtoNet protein and cluster: Q9NYG8

    3 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB008074 TRAAK K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK4_HUMAN, Q9NYG8
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Find genes that share domains with KCNK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNK4_HUMAN, Q9NYG8
    Function: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is
    reversed at high external K(+) concentrations (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005267potassium channel activity IEA--
         
    Find genes that share ontologies with KCNK4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNK4:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnk4):
     nervous system 

    Find genes that share phenotypes with KCNK4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnk4tm1Lzd for KCNK4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNK4
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    hsa-miR-1304 hsa-miR-1294 hsa-miR-9 hsa-miR-133a hsa-miR-1827 hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidKCNK4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNK4_HUMAN, Q9NYG8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KCNK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNK4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Tandem pore domain potassium channels0.00
    Potassium transporters outward current0.41
    TWIK related potassium channel (TREK)0.00
    2Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41


    Find genes that share SuperPaths with KCNK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNK4 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    1 Reactome Pathway for KCNK4
        TWIK related potassium channel (TREK)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNK4
    Interactions:

        Search GeneGlobe Interaction Network for KCNK4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KCNK4 (ENSP000003780334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNK10ENSP000003105684STRING: ENSP00000310568
    KCNK2ENSP000003940334STRING: ENSP00000394033
    DIDO1ENSP000002660704STRING: ENSP00000266070
    RPL14ENSP000003451564STRING: ENSP00000345156
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS10767409
    GO:0007268synaptic transmission TAS--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with KCNK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNK4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    2 IUPHAR Ligands for KCNK4 (K2P4.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    arachidonic acid
    ActivatorNone--
    riluzole
    ActivatorNone--

    2 Novoseek inferred chemical compound relationships for KCNK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 66.8 8 11172753 (1), 19967058 (1), 9880510 (1), 10744694 (1) (see all 7)
    potassium 29.8 1 11165377 (1)



    Find genes that share compounds with KCNK4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNK4 gene (3 alternative transcripts): 
    NM_033310.2  NM_016611.2  NM_033311.1  

    Unigene Cluster for KCNK4:

    Potassium channel, subfamily K, member 4
    Hs.647233  [show with all ESTs]
    Unigene Representative Sequence: NM_033310
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538846(uc009ypl.1) ENST00000538767 ENST00000422670 ENST00000453423
    ENST00000539651 ENST00000541349 ENST00000545838 ENST00000394525 ENST00000539216
    ENST00000536690
    miRNA
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    hsa-miR-1304 hsa-miR-1294 hsa-miR-9 hsa-miR-133a hsa-miR-1827 hsa-miR-133b
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    Additional mRNA sequence: 

    AF248242.1 AF259500.1 AK296021.1 AK307135.1 AK309443.1 BC067791.1 BC110327.1 EU978935.1 

    7 DOTS entries:

    DT.95108303  DT.95301579  DT.100677301  DT.120721358  DT.120721360  DT.441967  DT.95268720 

    Selected AceView cDNA sequences (see all 75):

    NM_016611 BX477630 BX095668 CR624550 CD300132 BM548747 AA587615 AL117564 
    AI816233 CR603880 AF248242 BI831531 AL537215 NM_033311 AA974777 BI458972 
    BX477647 AF247042 BI830871 BM676780 BX477629 AA865921 BI560762 BG191912 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNK4 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^
    SP1:                                            -     -     -                       -                                                                 -         
    SP2:                    -     -     -     -     -     -     -                       -                                                                           
    SP3:                                            -     -     -                       -     -     -     -                                                         
    SP4:                                                        -                       -                                                                           
    SP5:                                                                                -                                                                           

    ExUns: 12 ^ 13 ^ 14
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KCNK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCTTGT
    KCNK4 Expression
    About this image

    KCNK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647233
        Custom PCR Arrays for KCNK4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNK4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk41 , 5 potassium channel, subfamily K, member 41, 5 81.51(n)1
    82.44(a)1
      19 (5.08 cM)5
    165281  NM_008431.21  NP_032457.11 
     69257105 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    32(a)
    many ↔ many
    5(54839246-54849270) ENSGALG00000012021
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    many ↔ many
    GL343261.1(1886624-1896458)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnk41 potassium channel, subfamily K, member 4 60.14(n)
    59.05(a)
      100488063  XM_004913637.1  XP_004913694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BX465841.16
    Uncharacterized protein
    36(a)
    1 ↔ 1
    21(25971151-25986939) ENSDARG00000073749


    ENSEMBL Gene Tree for KCNK4 (if available)
    TreeFam Gene Tree for KCNK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNK4 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  
    KCNK102  KCNK72  KCNK172  KCNK132  KCNK12  
    6 SIMAP similar genes for KCNK4 using alignment to 5 protein entries:     KCNK4_HUMAN (see all proteins):
    KCNK2    KCNK10    KCNK16    KCNK1    KCNK6    KCNK17

    Find genes that share paralogs with KCNK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNK4 (see all 181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920521551,2
    --64057557(+) CACCAC/TGTTGC 1 -- us2k10--------
    rs1830569221,2
    --64057564(+) TTGCCC/TAGGCT 1 -- us2k10--------
    rs2021356941,2
    C--64057578(+) TCGAA-/CCCCCC 1 -- us2k10--------
    rs1870275701,2
    --64058107(+) AATCAA/GCTTGA 1 -- us2k10--------
    rs1917508511,2
    --64058183(+) GCCAGG/TCTCTG 1 -- us2k10--------
    rs1850739721,2
    --64058193(+) GTTTTA/GAGGAT 1 -- us2k10--------
    rs1890924051,2
    --64058213(+) CTGGCC/TTCCTT 1 -- us2k10--------
    rs609972461,2
    C--64058280(+) AACAGA/GGAGAC 1 -- us2k10--------
    rs22324071,2
    C,F,H--64058325(+) AGTAGC/TGGGTG 1 -- us2k15Minor allele frequency- T:0.01NS NA 586
    rs1995105741,2
    C--64058373(+) GAGGGC/GTGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNK4 (64058774 - 64067503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for KCNK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv357CNV Insertion18451855
    nsv897685CNV Loss21882294
    dgv1168n71CNV Loss21882294
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    nsv897684CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNK4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605720    OMIM disorders: --

    1 disease for KCNK4:    
    About MalaCards
    dentin sensitivity

    1 disease from the University of Copenhagen DISEASES database for KCNK4:
    Dentin sensitivity

    Find genes that share disorders with KCNK4           About GenesLikeMe

    1 Novoseek inferred disease relationship for KCNK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 10.3 1 10744694 (1)

    Genetic Association Database (GAD): KCNK4
    Human Genome Epidemiology (HuGE) Navigator: KCNK4 (3 documents)

    Export disorders for KCNK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNK4 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with KCNK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human TRAAK, a polyunsaturated fatty acids- activated and mechano-sensitive K(+) channel. (PubMed id 10767409)1, 2, 3 Lesage F.... Lazdunski M. (FEBS Lett. 2000)
    2. Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two- pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. (PubMed id 12191490)1, 2, 9 Ozaita A. and Vega-Saenz de Miera E. (Brain Res. Mol. Brain Res. 2002)
    3. Crystal structure of the human K2P TRAAK, a lipid- and mechano- sensitive K+ ion channel. (PubMed id 22282805)1, 2 Brohawn S.G.... MacKinnon R. (Science 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. (PubMed id 11042359)1, 2 Chapman C.G.... Gloger I.S. (Brain Res. Mol. Brain Res. 2000)
    8. The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. (PubMed id 11172753)1, 9 Meadows H.J....Randall A.D. (Brain Res. 2001)
    9. Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. (PubMed id 23341632)1 Brohawn S.G....MacKinnon R. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. (PubMed id 22837380)1 Fischer A....Schreiber S. (Am. J. Respir. Crit. Care Med. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50801 HGNC: 6279 AceView: KCNK4 Ensembl:ENSG00000182450 euGenes: HUgn50801
    ECgene: KCNK4 H-InvDB: KCNK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KCNK4 gene:
    Search GeneIP for patents involving KCNK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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