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Aliases for KCNK3 Gene

Aliases for KCNK3 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 3 2 3
  • TASK 3 4 6
  • Acid-Sensitive Potassium Channel Protein TASK-1 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 1 3 4
  • Two Pore Potassium Channel KT3.1 3 4
  • Two Pore K(+) Channel KT3.1 3 4
  • PPH4 3 6
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 3 3
  • Acid-Sensitive Potassium Channel Protein TASK 3
  • Potassium Channel, Subfamily K, Member 3 2
  • TWIK-Related Acid-Sensitive K+ Channel 3
  • Potassium Channel Subfamily K Member 3 3
  • Two P Domain Potassium Channel 3
  • Cardiac Potassium Channel 3
  • K2p3.1 3
  • TASK-1 3
  • TBAK1 3
  • TASK1 4
  • OAT1 3

External Ids for KCNK3 Gene

Previous GeneCards Identifiers for KCNK3 Gene

  • GC02P026836
  • GC02P027008
  • GC02P026890
  • GC02P026827
  • GC02P026654

Summaries for KCNK3 Gene

Entrez Gene Summary for KCNK3 Gene

  • This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for KCNK3 Gene

KCNK3 (Potassium Channel, Two Pore Domain Subfamily K, Member 3) is a Protein Coding gene. Diseases associated with KCNK3 include pulmonary hypertension, primary, 4 and pulmonary hypertension. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and protein C-terminus binding. An important paralog of this gene is KCNK10.

UniProtKB/Swiss-Prot for KCNK3 Gene

  • pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Tocris Summary for KCNK3 Gene

Gene Wiki entry for KCNK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK3 Gene

Genomics for KCNK3 Gene

Regulatory Elements for KCNK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK3 Gene

Start:
26,692,690 bp from pter
End:
26,733,420 bp from pter
Size:
40,731 bases
Orientation:
Plus strand

Genomic View for KCNK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK3 Gene

Proteins for KCNK3 Gene

  • Protein details for KCNK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14649-KCNK3_HUMAN
    Recommended name:
    Potassium channel subfamily K member 3
    Protein Accession:
    O14649
    Secondary Accessions:
    • Q53SU2

    Protein attributes for KCNK3 Gene

    Size:
    394 amino acids
    Molecular mass:
    43518 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Inhibited by external acidification. Activated by halothane and isoflurane

neXtProt entry for KCNK3 Gene

Proteomics data for KCNK3 Gene at MOPED

Post-translational modifications for KCNK3 Gene

  • Glycosylation at Asn53
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK3 Gene

Domains for KCNK3 Gene

Gene Families for KCNK3 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

Suggested Antigen Peptide Sequences for KCNK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14649

UniProtKB/Swiss-Prot:

KCNK3_HUMAN :
  • O14649
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK3: view

Function for KCNK3 Gene

Molecular function for KCNK3 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel inwardly rectifying,subfamily K,member 3
UniProtKB/Swiss-Prot Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Gene Ontology (GO) - Molecular Function for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IMP 12198146
GO:0005252 open rectifier potassium channel activity IEA --
GO:0005267 potassium channel activity TAS 9312005
GO:0005515 protein binding --
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with KCNK3: view
genes like me logo Genes that share phenotypes with KCNK3: view

Animal Models for KCNK3 Gene

MGI Knock Outs for KCNK3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK3 Gene

Localization for KCNK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK3 Gene COMPARTMENTS Subcellular localization image for KCNK3 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9312005
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNK3: view

Pathways for KCNK3 Gene

genes like me logo Genes that share pathways with KCNK3: view

Gene Ontology (GO) - Biological Process for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 9312005
GO:0007268 synaptic transmission TAS --
GO:0007420 brain development IEA --
GO:0030322 stabilization of membrane potential IBA --
GO:0034220 ion transmembrane transport IMP 12198146
genes like me logo Genes that share ontologies with KCNK3: view

Compounds for KCNK3 Gene

(5) Tocris Compounds for KCNK3 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(2) Drugbank Compounds for KCNK3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Doxapram
309-29-5 target inhibitor
Halothane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target binder

(2) IUPHAR Ligand for KCNK3 Gene

Ligand Type Action Affinity Pubmed IDs
halothane Activator None
anandamide Channel blocker None

(7) Novoseek inferred chemical compound relationships for KCNK3 Gene

Compound -log(P) Hits PubMed IDs
glutaric acid 65.7 1
potassium 61.8 6
arachidonic acid 39.2 1
lysine 35.1 1
histidine 29.7 1
genes like me logo Genes that share compounds with KCNK3: view

Transcripts for KCNK3 Gene

mRNA/cDNA for KCNK3 Gene

Unigene Clusters for KCNK3 Gene

Potassium channel, subfamily K, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK3 Gene

No ASD Table

Relevant External Links for KCNK3 Gene

GeneLoc Exon Structure for
KCNK3
ECgene alternative splicing isoforms for
KCNK3

Expression for KCNK3 Gene

mRNA expression in normal human tissues for KCNK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK3 Gene

This gene is overexpressed in Adrenal Gland (22.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK3 Gene

SOURCE GeneReport for Unigene cluster for KCNK3 Gene Hs.645288

mRNA Expression by UniProt/SwissProt for KCNK3 Gene

O14649-KCNK3_HUMAN
Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon
genes like me logo Genes that share expressions with KCNK3: view

In Situ Assay Products

Orthologs for KCNK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK3 35
  • 94.67 (n)
  • 95.94 (a)
KCNK3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK3 35
  • 95.85 (n)
  • 96.45 (a)
KCNK3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk3 35
  • 92.13 (n)
  • 91.37 (a)
Kcnk3 16
Kcnk3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk3 35
  • 91.03 (n)
  • 91.37 (a)
chicken
(Gallus gallus)
Aves KCNK3 36
  • 86 (a)
OneToOne
KCNK9 35
  • 83.16 (n)
  • 87.76 (a)
lizard
(Anolis carolinensis)
Reptilia KCNK3 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk3 35
  • 71.5 (n)
  • 74.87 (a)
kcnk3 36
  • 74 (a)
OneToMany
KCNK3 (2 of 2) 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Task6 36
  • 41 (a)
ManyToMany
Task7 36
  • 47 (a)
ManyToMany
CG9637 37
  • 54 (a)
CG9361 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea sup-9 36
  • 50 (a)
ManyToMany
twk-20 36
  • 37 (a)
ManyToMany
twk-23 37
  • 58 (a)
twk-4 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for KCNK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNK3 Gene

ENSEMBL:
Gene Tree for KCNK3 (if available)
TreeFam:
Gene Tree for KCNK3 (if available)

Paralogs for KCNK3 Gene

Selected SIMAP similar genes for KCNK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNK3: view

Variants for KCNK3 Gene

Sequence variations from dbSNP and Humsavar for KCNK3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs736699 -- 26,691,062(+) TCTAC(A/G)TTGCC upstream-variant-2KB
rs935166 -- 26,726,498(+) CCAGC(A/G)TCATT intron-variant
rs935167 -- 26,711,450(-) GAAAT(G/T)GGAGT intron-variant
rs935168 -- 26,691,919(+) CCTGA(A/G)AACAG upstream-variant-2KB
rs935169 -- 26,691,923(+) AGAAC(A/C)GGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK3 Gene

Variant ID Type Subtype PubMed ID
nsv523435 CNV Loss 19592680
dgv4071n71 CNV Loss 21882294
nsv508833 CNV Insertion 20534489
nsv522805 CNV Loss 19592680
esv26532 CNV Loss 19812545
nsv2652 CNV Insertion 18451855
esv1018822 CNV Insertion 17803354
esv989007 CNV Insertion 20482838
nsv2653 CNV Insertion 18451855

Relevant External Links for KCNK3 Gene

HapMap Linkage Disequilibrium report
KCNK3
Human Gene Mutation Database (HGMD)
KCNK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK3 Gene

Disorders for KCNK3 Gene

(1) OMIM Diseases for KCNK3 Gene (603220)

UniProtKB/Swiss-Prot

KCNK3_HUMAN
  • Pulmonary hypertension, primary, 4 (PPH4) [MIM:615344]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. {ECO:0000269 PubMed:23883380}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KCNK3 Gene

Relevant External Links for KCNK3

Genetic Association Database (GAD)
KCNK3
Human Genome Epidemiology (HuGE) Navigator
KCNK3
genes like me logo Genes that share disorders with KCNK3: view

Publications for KCNK3 Gene

  1. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PMID: 9721223) Lesage F. … Lazdunski M. (Genomics 1998) 2 3 23
  2. TASK-5, a novel member of the tandem pore K+ channel family. (PMID: 11680614) Ashmole I. … Stanfield P.R. (Pflugers Arch. 2001) 3 4 23
  3. TASK, a human background K+ channel to sense external pH variations near physiological pH. (PMID: 9312005) Duprat F. … Lazdunski M. (EMBO J. 1997) 2 3 4
  4. Inhalational anesthetics activate two-pore-domain background K+ channels. (PMID: 10321245) Patel A.J. … Lazdunski M. (Nat. Neurosci. 1999) 3 4
  5. Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation. (PMID: 18824070) Meuth S.G. … Wiendl H. (Neurosci. Lett. 2008) 3 23

Products for KCNK3 Gene

  • antibodies-online peptides for KCNK3
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  • antibodies-online kits for KCNK3

Sources for KCNK3 Gene

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