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Aliases &
Descriptions
for KCNK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
User Feedback | | Aliases & Descriptions |
|---|
| potassium channel, subfamily K, member 31 2 | | potassium inwardly-rectifying channel, subfamily K, member 32 | | TASK1 2 3 5 | | two P domain potassium channel2 | | TASK-11 2 | | potassium channel subfamily K member 32 | | K2p3.11 2 | | acid-sensitive potassium channel protein TASK2 | | Two pore potassium channel KT3.12 3 | | TWIK-related acid-sensitive K+ channel2 | | Two pore K(+) channel KT3.12 3 | | cardiac potassium channel2 | | Acid-sensitive potassium channel protein TASK-12 3 | | OAT12 | | TWIK-related acid-sensitive K(+) channel 12 3 | | TASK13 | | TBAK12 | | |
Search outside databases for aliases for KCNK3 genePrevious GC identifers: GC02P026836 GC02P027008 GC02P026890 |
Summaries
for KCNK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
User Feedback | Entrez Gene summary for KCNK3:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains.The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and isinhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated bythe anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there iscurrently no sequence available to confirm transcript variants for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results frompotassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassiumconcentration is low. When external potassium concentration is high, current is inward
Gene Wiki entry for KCNK3 |
Genomic Views
for KCNK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl (release 56),
Regulatory elements and Epigenetics data according to
SABiosciences)
About This Section
User Feedback | Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNK3 gene upstream (promoter) region  :
Egr-1 CUTL1 Max1 p300 GR-alpha c-Myc SRY Max p53 Chx10
Epigenetics:
SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for KCNK3: 
MePH02808-1A
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23KCNK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P026827: view genomic region
(about GC identifiers)
Start:
|
26,915,581 bp from pter |
End:
|
26,956,288 bp from pter |
Size:
|
40,708 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
| Proteins
for KCNK3 gene
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene,
Novus Biologicals, and/or
Sino Biological,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 May 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abnova,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
User Feedback | UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649 (See
protein sequence)Recommended Name: Potassium channel subfamily K member 3 Size: 394 amino acids; 43518 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Inhibited by external acidification. Activated by halothane and isoflurane Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002237.1
ENSEMBL proteins: ENSP00000306275
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KCNK3 for ontologies About GeneDecksing
Antibodies for KCNK3:
Assays for KCNK3: | Protein
Domains/
Families
for KCNK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
User Feedback |
KCNK3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14649ProtoNet protein and cluster: O14649 4 Blocks protein families: IPB003092 TASK K+ channel signature IPB003280 Two pore domain K+ channel signature IPB005406 TASK-1 K+ channel signature IPB013099 Ion transport 2
UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family | Gene Function
for KCNK3 gene
(According to MGI May 08 2010, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Millipore,
Abnova,
siRNAs from
Applied Biosystems,
Sigma-Aldrich, Clones from
Millipore,
Sigma-Aldrich,
OriGene,
Sino Biological,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene.)
About This Section
User Feedback | UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results frompotassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassiumconcentration is low. When external potassium concentration is high, current is inwardGenatlas biochemistry entry for KCNK3:potassium non voltage-gated channel inwardly rectifying,subfamily K,member 3 4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005267 | potassium channel activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0030955 | potassium ion binding |
-- | -- |
About this table
KCNK3 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Kcnk3):
KCNK3 for phenotypes About GeneDecksing
| Pathways & Interactions
for KCNK3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
Applied Biosystems GeneAssist,
KEGG
and/or UniProtKB,
(map by GeneGo),
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 May 2010 via
Entrez Gene).
About This Section
User Feedback |
KCNK3 for pathways About GeneDecksing
2  Millipore Pathways for KCNK3
5/16  GeneAssist Pathways for KCNK3 (see all 16
)
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNK3
1 Interacting protein for KCNK3 (ENSP000003062753 O146492) via UniProtKB, MINT, and/or STRING About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
KCNK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
User Feedback |
KCNK3 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for KCNK3 |
 Compounds for KCNK3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| YS-035 hydrochloride | Inhibits K+ outward/pacemaker current | [33978-72-2] | | DMP 543 | K+ channel blocker and potent ACh release enhancer | [160588-45-4] | | SG 209 | K+ channel opener; vasodilator | [83440-03-3] | | 4-Aminopyridine | Non-selective KV channel blocker | [504-24-5] |
About this table
10/44  Novoseek chemical compound relationships for KCNK3 gene (see all 44
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| potassium |
19.16 |
26 |
20167264 (2), 14504065 (2), 11733509 (2), 9721223 (1) (see all 23) |
| doxapram |
12.67 |
6 |
16492828 (6) |
| anandamide |
6.77 |
5 |
19930646 (2), 16424077 (2), 14576090 (1) |
| halothane |
6.72 |
8 |
16492828 (3), 17699638 (2), 12878686 (1), 12068035 (1) (see all 5) |
| ruthenium |
4.78 |
4 |
19403596 (2), 11733509 (2) |
| methanandamide |
4.53 |
2 |
16424077 (1), 12003807 (1) |
| treprostinil |
4.29 |
2 |
16574908 (2) |
| etomidate |
3.87 |
3 |
17699638 (3) |
| pip2 |
2.62 |
2 |
15677683 (2) |
| 1q41 |
2.44 |
1 |
9721223 (1) |
About this table
1 PharmGKB drug compound relationship for KCNK3 gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| antiarrhythmics | FA | 9312005 | About this table
|
Transcripts
for KCNK3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Primers from
OriGene and/or
SABiosciences,
Expression Assays from Applied Biosystems)
About This Section
User Feedback | Assays:  Applied Biosystems TaqMan® Gene Expression Assays: NM_002246
| Clones: |  | Origene GFP tagged cDNA clones in CMV expression vector: KCNK3
Origene Myc/DDK tagged cDNA clones in CMV expression vector: KCNK3
Origene untagged cDNA clones in CMV expression vector: KCNK3
|
| Primers: | | Origene genome-wide validated SYBR primer pairs: KCNK3
| | | SABiosciences RT2 qPCR Primer Assay for KCNK3: PPH08513A |
REFSEQ mRNAs for KCNK3 gene: NM_002246.2 Additional cDNA sequence: AF006823.1 AF065163.1 BC127956.1 BC140701.1 2 DOTS entries: DT.80102076 DT.100689298 24/139 AceView cDNA sequences (see all 139
): BF970101 BM052871 BG911236 AV710944 CK903866 BI042452 BF434972 AA349310 BQ286091 T48557 BU076210 BM052629 W40513 CK903865 BX338384 BU072522 BU072252 BU072226 BF515682 BM353741 BI117661 CA950669 BM353468 BM471814
 highest scoring ESTs for KCNK3:AF006823 AA069324 AA069377 AA918977 AA989521 AF065163 AI093258 AI148853 AI193606 AU137604 Unigene Cluster for KCNK3: Potassium channel, subfamily K, member 3 Hs.645288 [show with all ESTs]Unigene Representative Sequence: NM_002246
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000302909
|
Expression
for KCNK3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 223 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems,
Primers from
OriGene and/or
SABiosciences
)
About This Section
User Feedback | KCNK3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNK3
1 / 2 / 3 9 probe-sets matching KCNK3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 41325_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.91 |
0.73 |
AF006823 |
1.00 |
1.00 |
1.00 |
1 |
| 74268_at2, 3
|
U95-E |
1 |
0.69 |
1.00 |
0.87 |
1.33 |
AI807671 |
0.20 |
1.00 |
0.72 |
1 |
| 88977_at2, 3
|
U95-E |
1 |
0.31 |
1.00 |
0.80 |
0.94 |
R62375 |
0.20 |
1.00 |
0.72 |
1 |
| 205952_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_002246 |
0.60 |
1.00 |
0.82 |
1 |
| 228127_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
BF513479 |
0.20 |
1.00 |
0.72 |
1 |
| 235108_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
BG105700 |
0.20 |
1.00 |
0.72 |
1 |
| 205952_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 228127_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 235108_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KCNK3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCTCACGAC
SOURCE GeneReport for Unigene cluster: Hs.645288
Expression variation in blood from EXPOLDB for KCNK3 UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression inbrain, lung, prostate, heart, kidney, uterus, small intestine and colon
| Primers: | | Origene genome-wide validated SYBR primer pairs: KCNK3 
| | | SABiosciences RT2 qPCR Primer Assay for KCNK3: PPH08513A |
|
Orthologs
for KCNK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI May 08 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
User Feedback |
Orthologs for KCNK3 gene from 5/8 species (see all 8
)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
KCNK31 |
-- |
potassium channel, subfamily K, member 3 |
96.34(n)
97.13(a) |
483002 XM_540117.2 XP_540117.2 |
cow
(Bos taurus) |
KCNK31 |
-- |
potassium channel, subfamily K, member 3 |
95.43(n)
97.72(a) |
519188 XM_597401.3 XP_597401.3 |
rat
(Rattus norvegicus) |
Kcnk31 |
-- |
potassium channel, subfamily K, member 3 |
91.37(n)
92.13(a) |
29553 NM_033376.1 NP_203694.1 |
mouse
(Mus musculus) |
Kcnk31, 5 |
5 (18.00 cM)5
|
potassium channel, subfamily K, member 31, 5 |
92.22(n)1
91.88(a)1 |
165271 NM_010608.21 NP_034738.11
AB0085375 AB0133455 (see all 18) |
zebrafish
(Danio rerio) |
si:dkey-164m15.11 |
-- |
si:dkey-164m15.1 |
71.07(n)
74.87(a) |
561866 NM_001030162.1 NP_001025333.1 |
About this table Species with no ortholog for KCNK3
ENSEMBL Gene Tree for KCNK3 | Paralogs
for KCNK3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
User Feedback | Paralogs for KCNK3 gene
- KCNK152 KCNK52 KCNK162 KCNK122 KCNK92 KCNK62 KCNK22 KCNK182
- KCNK72 KCNK102 KCNK172 KCNK132 KCNK42 KCNK12
KCNK3 for paralogs About GeneDecksing
|
Genomic Variants
for KCNK3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants,
Genotyping Reagents from
Applied Biosystems)
About This Section
User Feedback |
HapMap Linkage Disequilibrium images for KCNK3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for KCNK3
4 CNVs: 33938 35806 73111 35805 |
Disorders & Mutations
for KCNK3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
User Feedback |
KCNK3 for disorders About GeneDecksing
OMIM: 603220
10/16 Novoseek disease relationships for KCNK3 gene (see all 16
)
About this table
Genetic Association Database: KCNK3
Human Genome Epidemiology Navigator: KCNK3 (1 document)
|
Medical News
for KCNK3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
User Feedback | -- |
Publications
for KCNK3 gene (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
User Feedback | 10/63 PubMed articles for KCNK3 gene (see all 63
):- TASK, a human background K+ channel to sense external pH variations near physiological pH. (PubMed id 9312005)2, 3, 4, 7 Duprat F.... Lazdunski M. (1997)
- TASK-5, a novel member of the tandem pore K+ channel family. (PubMed id 11680614)1, 3, 4 Ashmole I.... Stanfield P.R. (2001)
- Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PubMed id 9721223)1, 2, 3 Lesage F. and Lazdunski M. (1998)
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)2, 3 Goldstein S.A....Rajan S. (2005)
- Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. (PubMed id 11803450)3, 6 Koronyo-Hamaoui M....Gak E. (2002)
- Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. (PubMed id 10748056)3, 4 Lopes C.M....Goldstein S.A. (2000)
- Inhalational anesthetics activate two-pore-domain background K+ channels. (PubMed id 10321245)3, 4 Patel A.J.... Lazdunski M. (1999)
- Impact of TASK-1 in human pulmonary artery smooth muscle cells. (PubMed id 16574908)1, 3 Olschewski A....Olschewski H. (2006)
- Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. (PubMed id 12433946)1, 3 Rajan S....Daut J. (2002)
- p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. (PubMed id 12198146)1, 3 Girard C....Borsotto M. (2002)
|
Search for KCNK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
User Feedback |
|
Genome Databases showing KCNK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
User Feedback |
| Other Databases showing KCNK3 gene
(According to HUGE)
About This Section
User Feedback | -- |
Specialized Databases showing KCNK3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
User Feedback |
| About This Section
User Feedback | Patent Information for KCNK3 gene:
Search GeneIP for patents involving KCNK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
| Services
for KCNK3 gene(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
User Feedback | 
Products for KCNK3:
 | |
 | | | | |
 |  |  |  | |
| |  | Tocris compounds for KCNK3 |
| |
 |  |  |  | | | | |
|
User Feedback
|
