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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK3 Gene

protein-coding   GIFtS: 63
GCID: GC02P026827

potassium channel, subfamily K, member 3
 Explore 11 diseases affiliated with
KCNK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNK3    

Aliases
for KCNK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Channel, Subfamily K, Member 31 2     TBAK12
TASK1 2 3 5     Acid-Sensitive Potassium Channel Protein TASK2
K2p3.11 2     Cardiac Potassium Channel2
TASK-11 2     Potassium Channel Subfamily K Member 32
Acid-Sensitive Potassium Channel Protein TASK-12 3     Potassium Inwardly-Rectifying Channel, Subfamily K, Member 32
Two Pore K(+) Channel KT3.12 3     TWIK-Related Acid-Sensitive K+ Channel2
Two Pore Potassium Channel KT3.12 3     Two P Domain Potassium Channel2
TWIK-Related Acid-Sensitive K(+) Channel 12 3     TASK13
OAT12     

External Ids:    HGNC: 62781   Entrez Gene: 37772   Ensembl: ENSG000001713037   OMIM: 6032205   UniProtKB: O146493   

Export aliases for KCNK3 gene to outside databases

Previous GC identifers: GC02P026836 GC02P027008 GC02P026890 GC02P026654


Summaries
for KCNK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNK3:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains.
The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is
inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by
the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is
currently no sequence available to confirm transcript variants for this gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649
Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from
potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium
concentration is low. When external potassium concentration is high, current is inward

Gene Wiki entry for KCNK3


Genomic Views
for KCNK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK3 gene promoter:
         GR   NF-1/L   NF-1   NRSF form 1   GR-beta   NRSF form 2   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

KCNK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026827:  view genomic region     (about GC identifiers)

Start:
 26,915,581 bp from pter      End:
 26,956,288 bp from pter
Size:
 40,708 bases      Orientation:
 plus strand

Proteins
for KCNK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 3  
Size: 394 amino acids; 43518 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Inhibited by external acidification. Activated by halothane and isoflurane
Secondary accessions: Q53SU2

Explore the universe of human proteins at neXtProt for KCNK3: NX_O14649

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14649

    • KCNK3 Protein expression data from MOPED and PaxDb:    About this image 
    KCNK3 Protein Expression
    REFSEQ proteins: NP_002237.1  
    ENSEMBL proteins: 
     ENSP00000306275  
    Reactome Protein details: O14649
    Human Recombinant Protein Products for KCNK3: 
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    Novus Biologicals KCNK3 Lysate
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    Uscn Proteins for KCNK3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9312005
    GO:0016021integral to membrane ----

    KCNK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNK3

    Protein Domains /
    Families
    for KCNK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005406 2pore_dom_K_chnl_TASK1
     IPR003280 2pore_dom_K_chnl
     IPR022306 2pore_dom_K_chnl_TASK/TWIK
     IPR003092 2pore_dom_K_chnl_TASK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry O14649

    ProtoNet protein and cluster: O14649

    4 Blocks protein families:
    IPB003092 TASK K+ channel signature
    IPB003280 Two pore domain K+ channel signature
    IPB005406 TASK-1 K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Function
    for KCNK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNK3_HUMAN, O14649
    Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from
    potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium
    concentration is low. When external potassium concentration is high, current is inward

         Genatlas biochemistry entry for KCNK3:
    potassium non voltage-gated channel inwardly rectifying,subfamily K,member 3

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005252open rectifier potassium channel activity IEA--
    GO:0005267potassium channel activity TAS9312005
    GO:0005515protein binding ----
    GO:0008022protein C-terminus binding IEA--
    GO:0042803protein homodimerization activity IEA--
         
    KCNK3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnk3):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  nervous system 
     no phenotypic analysis  respiratory system 

    KCNK3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for KCNK3: Kcnk3tm1.1Daba Kcnk3tm1Sgb
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCNK3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNK3
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNK3 (see all 68):
    hsa-miR-637 hsa-miR-92b hsa-miR-761 hsa-miR-34c-5p hsa-miR-4300 hsa-miR-130a* hsa-miR-4297 hsa-miR-3669
    SwitchGear 3'UTR luciferase reporter plasmid: KCNK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK3


    Pathways & Interactions
    for KCNK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sweet Taste Signaling
    		Sweet Taste Signaling1.00
    		Bitter Taste Signaling0.44
    		Melatonin Signaling0.72
    		Sperm Motility0.36
    		Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Cholera Infection0.40
    		Aldosterone Signaling in Epithelial Cells0.47
    4Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    		MODY (Maturity-Onset Diabetes of Young)0.41
    5Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    		Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics1.00
    		Nicotine Activity on Dopaminergic Neurons0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for KCNK3
        Potassium transporters- inward current
    Synaptic transmission- ion currents

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK3 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    1 BioSystems Pathway for KCNK3 
        Nicotine Activity on Dopaminergic Neurons

    4        Reactome Pathways for KCNK3
        Potassium Channels
    TWIK-releated acid-sensitive K+ channel (TASK)
    Neuronal System
    Tandem pore domain potassium channels

    2 PharmGKB Pathways for KCNK3
        Antiarrhythmic Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics


    KCNK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for KCNK3 (O146492, 3 ENSP000003062754) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8006209 MINT-15089 MINT-15088 MINT-8006231 I2D: score=4 STRING: ENSP00000300161
    S100A10P609033, ENSP000003577994I2D: score=3 STRING: ENSP00000357799
    SFNP319473, ENSP000003409894I2D: score=1 STRING: ENSP00000340989
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    COPB1P536183, ENSP000002499234I2D: score=3 STRING: ENSP00000249923
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS9312005
    GO:0007268synaptic transmission TAS--
    GO:0007420brain development IEA--
    GO:0042493response to drug IEA--
    GO:0051481reduction of cytosolic calcium ion concentration IEA--

    KCNK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNK3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]

    2 DrugBank Compounds for KCNK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Doxapram-- 309-29-5targetinhibitor7617294 1667613 17227289
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetbinder20217349 20519544

    7 Novoseek chemical compound relationships for KCNK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutaric acid 65.7 2 17353191 (1)
    potassium 61.8 7 9721223 (1), 11886861 (1), 11165377 (1), 16837582 (1) (see all 6)
    arachidonic acid 39.2 1 11165377 (1)
    lysine 35.1 2 15284350 (1)
    histidine 29.7 1 15284350 (1)
    glutamate 7.59 2 15284350 (1)
    arginine 3.41 1 17353191 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNK3 

    Transcripts
    for KCNK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNK3 gene: 
    NM_002246.2  

    Unigene Cluster for KCNK3:

    Potassium channel, subfamily K, member 3
    Hs.645288  [show with all ESTs]
    Unigene Representative Sequence: NM_002246
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302909(uc002rhn.2)

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    hsa-miR-637 hsa-miR-92b hsa-miR-761 hsa-miR-34c-5p hsa-miR-4300 hsa-miR-130a* hsa-miR-4297 hsa-miR-3669
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF006823.1 AF065163.1 BC140701.1 

    2 DOTS entries:

    DT.80102076  DT.100689298 

    24/139 AceView cDNA sequences (see all 139):

    BI042452 AA349310 BF434972 BU076210 BQ286091 T48557 BM353741 BU072226 
    BF515682 BU072252 BU072522 BX338384 CK903865 W40513 BM052629 BM052871 
    BF970101 CK903866 AV710944 BG911236 AV707516 AF065163 AA987998 AI193606 

    GeneLoc Exon Structure


    Expression
    for KCNK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTCACGAC
    KCNK3 Expression
    About this image

    KCNK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartBundle of HisHis Bundle CellsMyocardium
    HeartFast Conducting SystemVentricular Conductive CellsMyocardium
    HeartPurkinje FibersPurkinje Fiber CellsMyocardium
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNK3

    SOURCE GeneReport for Unigene cluster: Hs.645288

    UniProtKB/Swiss-Prot: KCNK3_HUMAN, O14649
    Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in
    brain, lung, prostate, heart, kidney, uterus, small intestine and colon

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK3

    Orthologs
    for KCNK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNK3 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNK91 potassium channel, subfamily K, member 9 83.16(n)
    87.76(a)    		   428382  XM_003641055.1  XP_003641103.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNK36
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343824.1(996-1925)
    zebrafish
    (Danio rerio)    		 Actinopterygii kcnk31 potassium channel, subfamily K, member 3 71.07(n)
    74.87(a)    		   561866  NM_001030162.1  NP_001025333.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG96373
    Task61    		 inward rectifier potassium channel3
    CG9637-PC1    		 54(a)
    (best of 2)3
    59.27(n)1
    55.64(a)1    		   87F73
    416711  NM_142043.21  NP_650300.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea twk-233
    sup-91    		 Expression: neurons, muscle3
    Protein SUP-91    		 58(a)
    (best of 2)3
    58.08(n)1
    60.23(a)1    		   II(2684746-2686974)3
    1736131  NM_061932.31  NP_494333.11 


    ENSEMBL Gene Tree for KCNK3 (if available)
    TreeFam Gene Tree for KCNK3 (if available) 

    Paralogs
    for KCNK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNK3 gene
    KCNK152  KCNK52  KCNK162  KCNK122  KCNK92  KCNK62  KCNK22  KCNK182  
    KCNK172  KCNK102  KCNK72  KCNK42  KCNK132  KCNK12  
    2 SIMAP similar genes for KCNK3 using alignment to 2 protein entries:     KCNK3_HUMAN (see all proteins):
    KCNK15    KCNK9

    KCNK3 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/692 NCBI SNPs in KCNK3 are shown (see all 692)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116920131,2
    		H--26913655(+) GAGGGA/GGGGGG 1 -- us2k1 tfbs3 trp30--------
    rs1859671081,2
    		--26913782(+) AGACGC/TGGGTA 1 -- us2k10--------
    rs1427179521,2
    		--26913926(+) ATTCTC/TTACAT 1 -- us2k10--------
    rs7366991,2
    		C,F,A,H--26913930(+) TCTACA/GTTGCC 1 -- us2k18Minor allele frequency- G:0.33NA WA EA 368
    rs1133381151,2
    		--26914087(+) CTGGGT/GTGTCA 1 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs739203381,2
    		C--26914139(+) CTGTGG/AGTAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1441004611,2
    		--26914181(+) GAGTCG/TGCTCT 1 -- us2k10--------
    rs134109831,2
    		C--26914349(+) gcctgT/Ggggat 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs12759881,2
    		C,F,A,H--26914364(-) GTGTCG/ATAGCA 1 -- us2k123Minor allele frequency- A:0.33NS EA NA WA 2764
    rs1443172291,2
    		--26914372(+) CACCTC/GGTTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNK3 (26915581 - 26956288 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for KCNK3
         4 CNVs: 33938 35806 73111 35805

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    Disorders / Diseases
    for KCNK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNK3 for disorders           About GeneDecksing

    OMIM gene information: 603220    OMIM disorders: --

    11 diseases for KCNK3:    About MalaCards
    prosopagnosia    anorexia nervosa    medulloblastoma    homocysteine
    choroiditis    seizures    pharyngitis    cerebritis
    hypoxia    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCNK3:
    Central sleep apnea
    Genetic Association Database (GAD): KCNK3
    Human Genome Epidemiology (HuGE) Navigator: KCNK3 (1 document)

    Export disorders for KCNK3 gene to outside databases

    Publications
    for KCNK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNK3 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with KCNK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TASK, a human background K+ channel to sense external pH variations near physiological pH. (PubMed id 9312005)1, 2, 3 Duprat F.... Lazdunski M. (1997)
    2. TASK-5, a novel member of the tandem pore K+ channel family. (PubMed id 11680614)1, 2, 9 Ashmole I.... Stanfield P.R. (2001)
    3. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PubMed id 9721223)1, 3, 9 Lesage F. and Lazdunski M. (1998)
    4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
    5. Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. (PubMed id 11803450)1, 4 Koronyo-Hamaoui M....Gak E. (2002)
    6. Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. (PubMed id 10748056)1, 2 Lopes C.M....Goldstein S.A. (2000)
    7. Inhalational anesthetics activate two-pore-domain background K+ channels. (PubMed id 10321245)1, 2 Patel A.J.... Lazdunski M. (1999)
    8. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. (PubMed id 12433946)1, 9 Rajan S....Daut J. (2002)
    9. Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action. (PubMed id 11886861)1, 9 Talley E.M. and Bayliss D.A. (2002)
    10. p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. (PubMed id 12198146)1, 9 Girard C....Borsotto M. (2002)

    External Searches for KCNK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3777 HGNC: 6278 AceView: KCNK3 Ensembl:ENSG00000171303 euGenes: HUgn3777
    ECgene: KCNK3 H-InvDB: KCNK3

    Other Databases showing KCNK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNK3 gene:
    Search GeneIP for patents involving KCNK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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