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Aliases for KCNK3 Gene

Aliases for KCNK3 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 3 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 3 2 3 5
  • Acid-Sensitive Potassium Channel Protein TASK-1 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 1 3 4
  • Two Pore Potassium Channel KT3.1 3 4
  • Two Pore K(+) Channel KT3.1 3 4
  • TASK 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 3 3
  • Acid-Sensitive Potassium Channel Protein TASK 3
  • Potassium Channel, Subfamily K, Member 3 2
  • TWIK-Related Acid-Sensitive K+ Channel 3
  • Two P Domain Potassium Channel 3
  • Cardiac Potassium Channel 3
  • K2p3.1 3
  • TASK-1 3
  • TBAK1 3
  • TASK1 4
  • OAT1 3
  • PPH4 3

External Ids for KCNK3 Gene

Previous GeneCards Identifiers for KCNK3 Gene

  • GC02P026836
  • GC02P027008
  • GC02P026890
  • GC02P026827
  • GC02P026654

Summaries for KCNK3 Gene

Entrez Gene Summary for KCNK3 Gene

  • This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for KCNK3 Gene

KCNK3 (Potassium Two Pore Domain Channel Subfamily K Member 3) is a Protein Coding gene. Diseases associated with KCNK3 include Pulmonary Hypertension, Primary, 4 and Heritable Pulmonary Arterial Hypertension. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and protein C-terminus binding. An important paralog of this gene is KCNK10.

UniProtKB/Swiss-Prot for KCNK3 Gene

  • pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Tocris Summary for KCNK3 Gene

Gene Wiki entry for KCNK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK3 Gene

Genomics for KCNK3 Gene

Regulatory Elements for KCNK3 Gene

Enhancers for KCNK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK3 Gene

Chromosome:
2
Start:
26,692,690 bp from pter
End:
26,733,420 bp from pter
Size:
40,731 bases
Orientation:
Plus strand

Genomic View for KCNK3 Gene

Genes around KCNK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK3 Gene

Proteins for KCNK3 Gene

  • Protein details for KCNK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14649-KCNK3_HUMAN
    Recommended name:
    Potassium channel subfamily K member 3
    Protein Accession:
    O14649
    Secondary Accessions:
    • Q53SU2

    Protein attributes for KCNK3 Gene

    Size:
    394 amino acids
    Molecular mass:
    43518 Da
    Quaternary structure:
    • Homodimer (Probable). Heterodimer with KCNK1.
    Miscellaneous:
    • Inhibited by external acidification. Activated by halothane and isoflurane.

neXtProt entry for KCNK3 Gene

Proteomics data for KCNK3 Gene at MOPED

Post-translational modifications for KCNK3 Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK3 Gene

Domains & Families for KCNK3 Gene

Gene Families for KCNK3 Gene

Suggested Antigen Peptide Sequences for KCNK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14649

UniProtKB/Swiss-Prot:

KCNK3_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK3: view

Function for KCNK3 Gene

Molecular function for KCNK3 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 3
UniProtKB/Swiss-Prot Function:
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.

Gene Ontology (GO) - Molecular Function for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IMP 12198146
GO:0005267 potassium channel activity IEA,TAS --
GO:0022841 potassium ion leak channel activity IDA 9312005
genes like me logo Genes that share ontologies with KCNK3: view
genes like me logo Genes that share phenotypes with KCNK3: view

Human Phenotype Ontology for KCNK3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KCNK3 Gene

MGI Knock Outs for KCNK3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KCNK3 Gene

Localization for KCNK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK3 Gene COMPARTMENTS Subcellular localization image for KCNK3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNK3: view

Pathways & Interactions for KCNK3 Gene

genes like me logo Genes that share pathways with KCNK3: view

SIGNOR curated interactions for KCNK3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IEA --
GO:0034220 ion transmembrane transport IMP 12198146
GO:0051481 negative regulation of cytosolic calcium ion concentration IEA --
GO:0090102 cochlea development IEA --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with KCNK3: view

Drugs & Compounds for KCNK3 Gene

(10) Drugs for KCNK3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxapram Approved Pharma Target, inhibitor 7
Halothane Approved Pharma Activator, Target, binder 1
Anandamide Pharma Antagonist, Pore Blocker 0
Doxapram HCl Pharma 0

(7) Additional Compounds for KCNK3 Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Kyselina trifluoroctova
  • Perfluoroacetic acid
  • Trifluoracetic acid
76-05-1
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3

(5) Tocris Compounds for KCNK3 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5

(1) ApexBio Compounds for KCNK3 Gene

Compound Action Cas Number
Doxapram HCl 7081-53-0
genes like me logo Genes that share compounds with KCNK3: view

Transcripts for KCNK3 Gene

mRNA/cDNA for KCNK3 Gene

Unigene Clusters for KCNK3 Gene

Potassium channel, subfamily K, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK3 Gene

No ASD Table

Relevant External Links for KCNK3 Gene

GeneLoc Exon Structure for
KCNK3
ECgene alternative splicing isoforms for
KCNK3

Expression for KCNK3 Gene

mRNA expression in normal human tissues for KCNK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK3 Gene

This gene is overexpressed in Adrenal Gland (x22.0).

Protein differential expression in normal tissues from HIPED for KCNK3 Gene

This gene is overexpressed in Lung (53.0) and Adrenal (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK3 Gene



SOURCE GeneReport for Unigene cluster for KCNK3 Gene Hs.645288

mRNA Expression by UniProt/SwissProt for KCNK3 Gene

O14649-KCNK3_HUMAN
Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
genes like me logo Genes that share expression patterns with KCNK3: view

Protein tissue co-expression partners for KCNK3 Gene

Primer Products

Orthologs for KCNK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK3 35
  • 94.67 (n)
  • 95.94 (a)
KCNK3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK3 35
  • 95.85 (n)
  • 96.45 (a)
KCNK3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk3 35
  • 92.13 (n)
  • 91.37 (a)
Kcnk3 16
Kcnk3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk3 35
  • 91.03 (n)
  • 91.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK9 35
  • 83.16 (n)
  • 87.76 (a)
KCNK3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK3 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk3 35
  • 71.5 (n)
  • 74.87 (a)
kcnk3 36
  • 74 (a)
OneToMany
KCNK3 (2 of 2) 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9361 37
  • 47 (a)
CG9637 37
  • 54 (a)
Task6 36
  • 41 (a)
ManyToMany
Task7 36
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea twk-23 37
  • 58 (a)
twk-4 37
  • 44 (a)
sup-9 36
  • 50 (a)
ManyToMany
twk-20 36
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for KCNK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNK3 Gene

ENSEMBL:
Gene Tree for KCNK3 (if available)
TreeFam:
Gene Tree for KCNK3 (if available)

Paralogs for KCNK3 Gene

(2) SIMAP similar genes for KCNK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNK3: view

Variants for KCNK3 Gene

Sequence variations from dbSNP and Humsavar for KCNK3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_070126 Pulmonary hypertension, primary, 4 (PPH4)
VAR_070127 Pulmonary hypertension, primary, 4 (PPH4)
VAR_070128 Pulmonary hypertension, primary, 4 (PPH4)
VAR_070129 Pulmonary hypertension, primary, 4 (PPH4)
VAR_070130 Pulmonary hypertension, primary, 4 (PPH4)

Structural Variations from Database of Genomic Variants (DGV) for KCNK3 Gene

Variant ID Type Subtype PubMed ID
nsv523435 CNV Loss 19592680
dgv4071n71 CNV Loss 21882294
nsv508833 CNV Insertion 20534489
nsv522805 CNV Loss 19592680
esv26532 CNV Loss 19812545
nsv2652 CNV Insertion 18451855
esv1018822 CNV Insertion 17803354
esv989007 CNV Insertion 20482838
nsv2653 CNV Insertion 18451855

Variation tolerance for KCNK3 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK3 Gene

Human Gene Mutation Database (HGMD)
KCNK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK3 Gene

Disorders for KCNK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KCNK3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary hypertension, primary, 4
  • primary pulmonary hypertension 4
heritable pulmonary arterial hypertension
  • familial primary pulmonary hypertension
birk-barel mental retardation dysmorphism syndrome
  • birk-barel syndrome
pulmonary hypertension
  • primary pulmonary hypertension
pulmonary venoocclusive disease
  • pulmonary veno-occlusive disease
- elite association - COSMIC cancer census association via MalaCards
Search KCNK3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KCNK3_HUMAN
  • Pulmonary hypertension, primary, 4 (PPH4) [MIM:615344]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. {ECO:0000269 PubMed:23883380}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KCNK3

Genetic Association Database (GAD)
KCNK3
Human Genome Epidemiology (HuGE) Navigator
KCNK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK3
genes like me logo Genes that share disorders with KCNK3: view

No data available for Genatlas for KCNK3 Gene

Publications for KCNK3 Gene

  1. TASK, a human background K+ channel to sense external pH variations near physiological pH. (PMID: 9312005) Duprat F. … Lazdunski M. (EMBO J. 1997) 2 3 4 67
  2. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PMID: 9721223) Lesage F. … Lazdunski M. (Genomics 1998) 2 3 23
  3. Halothane and sevoflurane exert different degrees of inhibition on carotid body glomus cell intracellular Ca2+ response to hypoxia. (PMID: 20217349) Pandit J.J. … Buckler K.J. (Adv. Exp. Med. Biol. 2010) 25 26
  4. Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. (PMID: 20519544) Lazarenko R.M. … Bayliss D.A. (J. Neurosci. 2010) 25 26
  5. Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation. (PMID: 18824070) Meuth S.G. … Wiendl H. (Neurosci. Lett. 2008) 3 23

Products for KCNK3 Gene

Sources for KCNK3 Gene

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