Aliases for KCNK2 Gene
- Potassium Channel, Two Pore Domain Subfamily K, Member 2 2 3
- Outward Rectifying Potassium Channel Protein TREK-1 3 4
- Two Pore Domain Potassium Channel TREK-1 3 4
- Two Pore Potassium Channel TPKC1 3 4
- TREK-1 K(+) Channel Subunit 3 4
- TREK1 3 4
- TREK 3 4
- Potassium Inwardly-Rectifying Channel, Subfamily K, Member 2 3
- Potassium Channel Subfamily K Member 2 Variant 1 3
- Potassium Channel Subfamily K Member 2 Variant 2 3
- Tandem-Pore-Domain Potassium Channel TREK-1 3
External Ids for KCNK2 Gene
Previous GeneCards Identifiers for KCNK2 Gene
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK2 Gene
KCNK2 (Potassium Channel, Two Pore Domain Subfamily K, Member 2) is a Protein Coding gene. Diseases associated with KCNK2 include dentin sensitivity. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNK3.
UniProtKB/Swiss-Prot for KCNK2 Gene
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).
Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.