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Aliases for KCNK2 Gene

Aliases for KCNK2 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 2 2 3
  • TREK 3 4 6
  • Outward Rectifying Potassium Channel Protein TREK-1 3 4
  • Two Pore Domain Potassium Channel TREK-1 3 4
  • Two Pore Potassium Channel TPKC1 3 4
  • TREK-1 K(+) Channel Subunit 3 4
  • TREK1 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 2 3
  • Potassium Channel Subfamily K Member 2 Variant 1 3
  • Potassium Channel Subfamily K Member 2 Variant 2 3
  • Tandem-Pore-Domain Potassium Channel TREK-1 3
  • Potassium Channel, Subfamily K, Member 2 2
  • Potassium Channel Subfamily K Member 2 3
  • TWIK-Related Potassium Channel 1 3
  • Two-Pore Potassium Channel 1 3
  • K2P2.1 Potassium Channel 3
  • HTREK-1c 3
  • HTREK-1e 3
  • K2p2.1 3
  • TREK-1 3
  • TPKC1 3

External Ids for KCNK2 Gene

Summaries for KCNK2 Gene

Entrez Gene Summary for KCNK2 Gene

  • This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK2 Gene

KCNK2 (Potassium Channel, Two Pore Domain Subfamily K, Member 2) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include outward rectifier potassium channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK2 Gene

  • Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.

  • Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Gene Wiki entry for KCNK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK2 Gene

Genomics for KCNK2 Gene

Genomic Location for KCNK2 Gene

Start:
215,005,542 bp from pter
End:
215,237,093 bp from pter
Size:
231,552 bases
Orientation:
Plus strand

Genomic View for KCNK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK2 Gene

Regulatory Elements for KCNK2 Gene

Proteins for KCNK2 Gene

  • Protein details for KCNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95069-KCNK2_HUMAN
    Recommended name:
    Potassium channel subfamily K member 2
    Protein Accession:
    O95069
    Secondary Accessions:
    • A1Z1V3
    • A8K618
    • B2RCS4
    • B7ZL56
    • D3DTA5
    • Q5DP47
    • Q5DP48
    • Q9NRT2
    • Q9UNE3

    Protein attributes for KCNK2 Gene

    Size:
    426 amino acids
    Molecular mass:
    47093 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Activated by volatile general anesthetics such as chloroform, halothane and isoflurane

    Three dimensional structures from OCA and Proteopedia for KCNK2 Gene

    Alternative splice isoforms for KCNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK2 Gene

Proteomics data for KCNK2 Gene at MOPED

Post-translational modifications for KCNK2 Gene

  • Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn110 and Asn134

No data available for DME Specific Peptides for KCNK2 Gene

Domains for KCNK2 Gene

Gene Families for KCNK2 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

UniProtKB/Swiss-Prot:

KCNK2_HUMAN
Domain:
  • The C-terminal region of isoform 4 mediates its intracellular retention.:
    • O95069
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.:
    • O95069
genes like me logo Genes that share domains with KCNK2: view

Function for KCNK2 Gene

Molecular function for KCNK2 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel inwardly rectifying,subfamily K,member 2
UniProtKB/Swiss-Prot Function: Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.
UniProtKB/Swiss-Prot Function: Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Gene Ontology (GO) - Molecular Function for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005267 potassium channel activity --
GO:0005515 protein binding --
GO:0015271 outward rectifier potassium channel activity ISS --
genes like me logo Genes that share ontologies with KCNK2: view
genes like me logo Genes that share phenotypes with KCNK2: view

Animal Models for KCNK2 Gene

MGI Knock Outs for KCNK2:

miRNA for KCNK2 Gene

miRTarBase miRNAs that target KCNK2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNK2 Gene

Localization for KCNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK2 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.
Isoform 4: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK2 Gene COMPARTMENTS Subcellular localization image for KCNK2 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0008076 voltage-gated potassium channel complex IEA --
genes like me logo Genes that share ontologies with KCNK2: view

Pathways for KCNK2 Gene

genes like me logo Genes that share pathways with KCNK2: view

Interacting Proteins for KCNK2 Gene

Gene Ontology (GO) - Biological Process for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
genes like me logo Genes that share ontologies with KCNK2: view

Compounds for KCNK2 Gene

(5) Tocris Compounds for KCNK2 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
Tetraethylammonium chloride Non-selective K+ channel blocker [56-34-8]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [33978-72-2]

(2) Drugbank Compounds for KCNK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dofetilide
  • Dofetilida [INN-Spanish]
115256-11-6 target inhibitor
Dronedarone
141626-36-0 target inhibitor

(3) IUPHAR Ligand for KCNK2 Gene

Ligand Type Action Affinity Pubmed IDs
halothane Activator None
arachidonic acid Activator Potentiation
riluzole Activator None

(7) Novoseek inferred chemical compound relationships for KCNK2 Gene

Compound -log(P) Hits PubMed IDs
riluzole 69 1
lysophosphatidylcholine 68 2
potassium 59.9 10
arachidonic acid 58.4 7
quinidine 54 1
genes like me logo Genes that share compounds with KCNK2: view

Transcripts for KCNK2 Gene

Unigene Clusters for KCNK2 Gene

Potassium channel, subfamily K, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for KCNK2 Gene

GeneLoc Exon Structure for
KCNK2
ECgene alternative splicing isoforms for
KCNK2

Expression for KCNK2 Gene

mRNA expression in normal human tissues for KCNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK2 Gene

This gene is overexpressed in Adrenal Gland (10.8).

SOURCE GeneReport for Unigene cluster for KCNK2 Gene Hs.497745

mRNA Expression by UniProt/SwissProt for KCNK2 Gene

O95069-KCNK2_HUMAN
Tissue specificity: Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
genes like me logo Genes that share expressions with KCNK2: view

Orthologs for KCNK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK2 36
  • 99.92 (n)
  • 99.76 (a)
KCNK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK2 36
  • 91.73 (n)
  • 99.03 (a)
KCNK2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK2 36
  • 90.66 (n)
  • 97.15 (a)
KCNK2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk2 36
  • 88.97 (n)
  • 96.35 (a)
Kcnk2 16
Kcnk2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK2 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk2 36
  • 88.81 (n)
  • 95.62 (a)
chicken
(Gallus gallus)
Aves KCNK2 36
  • 83.65 (n)
  • 92.65 (a)
KCNK2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK2 37
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk2a 37
  • 73 (a)
OneToMany
kcnk2b 37
  • 67 (a)
OneToMany
LOC559728 36
  • 71.37 (n)
  • 74.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
CSA.6929 37
  • 32 (a)
ManyToMany
Species with no ortholog for KCNK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK2 Gene

ENSEMBL:
Gene Tree for KCNK2 (if available)
TreeFam:
Gene Tree for KCNK2 (if available)

Paralogs for KCNK2 Gene

Selected SIMAP similar genes for KCNK2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with KCNK2: view

Variants for KCNK2 Gene

Sequence variations from dbSNP and Humsavar for KCNK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs896653 -- 215,004,377(-) CTAAT(C/T)TGTAG upstream-variant-2KB
rs965283 -- 215,020,460(+) tggct(C/G)tgtta intron-variant
rs1015244 -- 215,197,227(+) TCAAA(C/G)AATTA intron-variant
rs1112101 -- 215,186,915(+) CTAAA(A/G)GGTGA intron-variant
rs1156732 -- 215,033,108(+) gctca(C/G)aaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK2 Gene

Variant ID Type Subtype PubMed ID
esv2722695 CNV Deletion 23290073
esv2722706 CNV Deletion 23290073
nsv873169 CNV Gain 21882294
nsv160908 CNV Loss 16902084
esv1046148 CNV Deletion 17803354
esv272120 CNV Insertion 20981092
esv272882 CNV Insertion 20981092
nsv873170 CNV Loss 21882294
esv1227395 CNV Insertion 17803354
dgv24n21 CNV Loss 19592680
esv267571 CNV Insertion 20981092

Relevant External Links for KCNK2 Gene

HapMap Linkage Disequilibrium report
KCNK2

Disorders for KCNK2 Gene

(1) Novoseek inferred disease relationships for KCNK2 Gene

Disease -log(P) Hits PubMed IDs
acidosis 48.7 1

Relevant External Links for KCNK2

Genetic Association Database (GAD)
KCNK2
Human Genome Epidemiology (HuGE) Navigator
KCNK2
genes like me logo Genes that share disorders with KCNK2: view

No data available for UniProtKB/Swiss-Prot for KCNK2 Gene

Publications for KCNK2 Gene

  1. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PMID: 9721223) Lesage F. … Lazdunski M. (Genomics 1998) 2 3 23
  2. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. (PMID: 18288090) Perlis R.H. … Smoller J.W. (Neuropsychopharmacology 2008) 3 23 49
  3. A novel mechanism for human K2P2.1 channel gating. Facilitation of C-type gating by protonation of extracellular histidine residues. (PMID: 18474599) Cohen A. … Zilberberg N. (J. Biol. Chem. 2008) 3 23
  4. Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion. (PMID: 18854423) Brenner T. … O'Shaughnessy K.M. (Am. J. Physiol. Endocrinol. Metab. 2008) 3 23
  5. Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel. (PMID: 19130888) Cohen A. … Zilberberg N. (Mol. Cell. Neurosci. 2009) 3 23

Products for KCNK2 Gene

Sources for KCNK2 Gene

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