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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK2 Gene

protein-coding   GIFtS: 62
GCID: GC01P215178

Potassium Channel, Subfamily K, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 21 2     TREK-12
TREK2 3 5     hTREK-1c2
Outward Rectifying Potassium Channel Protein TREK-12 3     hTREK-1e2
Two Pore Domain Potassium Channel TREK-12 3     K2P2.1 Potassium Channel2
Two Pore Potassium Channel TPKC12 3     Potassium Channel Subfamily K Member 22
TREK12 3     Potassium Inwardly-Rectifying Channel, Subfamily K, Member 22
TREK-1 K(+) Channel Subunit2 3     Tandem-Pore-Domain Potassium Channel TREK-12
K2p2.12     TWIK-Related Potassium Channel 12
TPKC12     Two-Pore Potassium Channel 12

External Ids:    HGNC: 62771   Entrez Gene: 37762   Ensembl: ENSG000000824827   OMIM: 6032195   UniProtKB: O950693   

Export aliases for KCNK2 gene to outside databases

Previous GC identifers: GC01P213914 GC01P211077 GC01P211795 GC01P212313 GC01P211645 GC01P213245 GC01P185853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK2 Gene:
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type
of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to
control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane
stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNK2 Gene: 
KCNK2 (potassium channel, subfamily K, member 2) is a protein-coding gene. Diseases associated with KCNK2 include myofascial pain syndrome, and dentin sensitivity, and among its related super-pathways are Voltage gated Potassium channels and Melatonin Signaling. GO annotations related to this gene include outward rectifier potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNK2_HUMAN, O95069
Function: Outward rectifying potassium channel

Gene Wiki entry for KCNK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK2 gene promoter:
         Max1   FAC1   PPAR-gamma1   Nkx3-1 v1   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

KCNK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P215178:  view genomic region     (about GC identifiers)

Start:
215,178,885 bp from pter      End:
215,410,436 bp from pter
Size:
231,552 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNK2_HUMAN, O95069 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 2  
Size: 426 amino acids; 47093 Da
Subunit: Homodimer (Potential)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Activated by volatile general anesthetics such as chloroform, halothane and isoflurane
Secondary accessions: A1Z1V3 A8K618 B2RCS4 B7ZL56 D3DTA5 Q5DP47 Q5DP48 Q9NRT2 Q9UNE3
Alternative splicing: 4 isoforms:  O95069-1   O95069-2   O95069-3   O95069-4   

Explore the universe of human proteins at neXtProt for KCNK2: NX_O95069

Explore proteomics data for KCNK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95069

  • KCNK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNK2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001017424.1  NP_001017425.2  NP_055032.1  

    ENSEMBL proteins: 
     ENSP00000418706   ENSP00000420203   ENSP00000375765   ENSP00000420569   ENSP00000375764  
     ENSP00000419633   ENSP00000420499   ENSP00000394033   ENSP00000413460  
    Reactome Protein details: O95069
    Human Recombinant Protein Products for KCNK2: 
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    Cloud-Clone Corp. Proteins for KCNK2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane NAS--

    KCNK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P2.1 
    Two-P potassium channels

    3 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR003976 2pore_dom_K_chnl_TREK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry O95069

    ProtoNet protein and cluster: O95069

    3 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB003976 Trek K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK2_HUMAN, O95069
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    KCNK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNK2_HUMAN, O95069
    Function: Outward rectifying potassium channel

         Genatlas biochemistry entry for KCNK2:
    potassium non voltage-gated channel inwardly rectifying,subfamily K,member 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity ----
    GO:0005267potassium channel activity ----
    GO:0015271outward rectifier potassium channel activity NAS--
         
    KCNK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnk2):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    KCNK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KCNK2: Kcnk2tm1Lzd Kcnk2tm1Lex

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNK2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    2Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNK2
        Potassium transporters- outward current

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK2 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    4        Reactome Pathways for KCNK2
        Potassium Channels
    Neuronal System
    TWIK related potassium channel (TREK)
    Tandem pore domain potassium channels


    1         Kegg Pathway  (Kegg details for KCNK2):
        Gastric acid secretion


    KCNK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KCNK2 (ENSP000003940334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNK10ENSP000003105684STRING: ENSP00000310568
    KCNK4ENSP000003780334STRING: ENSP00000378033
    ATXN1ENSP000002447694STRING: ENSP00000244769
    FAM107BENSP000001817964STRING: ENSP00000181796
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport NAS--
    GO:0007186G-protein coupled receptor signaling pathway IEA--
    GO:0007268synaptic transmission TAS--
    GO:0055085transmembrane transport ----

    KCNK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    2 DrugBank Compounds for KCNK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DofetilideDofetilida [INN-Spanish] (see all 2)115256-11-6targetinhibitor17139284 17016423 17187453
    Dronedarone-- 141626-36-0targetinhibitor22790794

    3 IUPHAR Ligands for KCNK2 (K2P2.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    halothane
    ActivatorNone--
    arachidonic acid
    ActivatorNone--
    riluzole
    ActivatorNone--

    7 Novoseek inferred chemical compound relationships for KCNK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    riluzole 69 1 10880510 (1)
    lysophosphatidylcholine 68 3 10744694 (2)
    potassium 59.9 11 16250016 (2), 9721223 (1), 15090259 (1), 16006563 (1) (see all 9)
    arachidonic acid 58.4 11 17786632 (3), 11165377 (1), 15090259 (1), 16075240 (1) (see all 5)
    quinidine 54 1 9003761 (1)
    halothane 43.8 3 17699638 (1), 10880510 (1), 16075240 (1)
    quinine 38.5 1 9003761 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNK2 gene (3 alternative transcripts): 
    NM_001017424.2  NM_001017425.2  NM_014217.3  

    Unigene Cluster for KCNK2:

    Potassium channel, subfamily K, member 2
    Hs.497745  [show with all ESTs]
    Unigene Representative Sequence: NM_001017424
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486921 ENST00000467031 ENST00000391895 ENST00000478774 ENST00000391894
    ENST00000470177 ENST00000474771 ENST00000444842(uc010pua.1 uc001hko.3 uc009xdm.3 uc001hkp.3 uc001hkr.4 uc001hkq.3)
    ENST00000457122
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    Additional mRNA sequence: 

    AF004711.1 AF129399.1 AF171068.1 AK123409.1 AK291483.1 AK294780.1 AK315249.1 AY552980.1 
    AY552981.1 BC069462.1 BC101693.1 BC101695.1 BC143586.1 EF165334.1 EF165335.1 

    7 DOTS entries:

    DT.91818148  DT.91921277  DT.70100582  DT.101961247  DT.102840336  DT.97802874  DT.102823347 

    24/59 AceView cDNA sequences (see all 59):

    NM_014217 AU280191 AF171068 BU956092 CK820143 BC069462 BM273241 AK123409 
    CO248930 BF569718 AA464375 AF129399 BQ182978 AW166005 AA384113 CK820142 
    AF004711 BM273231 CO245300 CA441727 BG164227 BX478651 CO247894 BM354228 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNK2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:              -                                                   
    SP2:                                                                  
    SP3:                                      -                           
    SP4:                          -                                       


    ECgene alternative splicing isoforms for KCNK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNK2 expression in normal human tissues (normalized intensities)      KCNK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAACTGT
    KCNK2 Expression
    About this image


    KCNK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Fibroblast
             Detroit 551
             Human Lymphatic Fibroblasts (HLF)   
     
     Mesenchymal Stem Cells (Integumentary System)    fully expand to see all 4 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Dermis (Uncategorized)    fully expand to see all 4 entries
             BH2 Dermal Fibroblasts   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Normal Human Articular chondrocytes (NHAC)   
             fetal cartilage   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor W10

    See KCNK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNK2

    SOURCE GeneReport for Unigene cluster: Hs.497745
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNK2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk21 , 5 potassium channel, subfamily K, member 21, 5 89.2(n)1
    96.24(a)1
      1 (94.22 cM)5
    165261  NM_001159850.11  NP_001153322.11 
     1892079315 
    chicken
    (Gallus gallus)
    Aves KCNK21 potassium channel, subfamily K, member 2 83.78(n)
    93.67(a)
      770954  XM_001234269.1  XP_001234270.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK26
    potassium channel, subfamily K, member 2
    91(a)
    1 ↔ 1
    1(240267561-240387277)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5597281 potassium channel subfamily K member 2-like 70.04(n)
    72.94(a)
      559728  XM_683094.2  XP_688186.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ork16
    Open rectifier K[+] channel 1
    8(a)
    1 → many
    X(10772087-10784957)


    ENSEMBL Gene Tree for KCNK2 (if available)
    TreeFam Gene Tree for KCNK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNK2 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK102  
    KCNK72  KCNK172  KCNK42  KCNK132  KCNK12  
    6 SIMAP similar genes for KCNK2 using alignment to 6 protein entries:     KCNK2_HUMAN (see all proteins):
    KCNK16    KCNK10    KCNK4    KCNK17    KCNK1    KCNK6

    KCNK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4575 SNPs in KCNK2 are shown (see all 4575)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599488991,2
    C--185962524(+) TGTGT-/GT    
       
    /GTGT
    ACAAA
    2 -- int11NA 2
    rs121342081,2
    C,F,H--215176935(+) AACTCC/TGCGAC 1 -- us2k15Minor allele frequency- T:0.01NS EA NA 538
    rs1903509251,2
    --215176938(+) TCCGCA/GACCTG 1 -- us2k10--------
    rs1822854641,2
    --215176999(+) AGTCCA/CGCTAA 1 -- us2k10--------
    rs1877384811,2
    --215177012(+) CTCACA/CCTTAA 1 -- us2k10--------
    rs1437134141,2
    --215177203(+) TAACAC/TAGGAG 1 -- us2k10--------
    rs1932141011,2
    --215177225(+) CATTAA/GCCTCA 1 -- us2k10--------
    rs1382577401,2
    C--215177274(+) ATTCCC/TGACAT 1 -- us2k10--------
    rs1438544471,2
    C--215177277(+) CCCGAC/TATGAC 1 -- us2k10--------
    rs1838914941,2
    --215177310(+) CACTTC/TCTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNK2 (215178885 - 215410436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for KCNK2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722706CNV Deletion23290073
    esv2722695CNV Deletion23290073
    esv1046148CNV Deletion17803354
    esv1227395CNV Insertion17803354
    esv272882CNV Insertion20981092
    esv272120CNV Insertion20981092
    esv267571CNV Insertion20981092
    nsv160908CNV Loss16902084
    dgv24n21CNV Loss19592680
    nsv873170CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603219    OMIM disorders: --

    15 diseases for KCNK2:    About MalaCards
    myofascial pain syndrome    dentin sensitivity    scabies    paine syndrome
    maturity-onset diabetes of the young    migraine    cholera    esophageal squamous cell carcinoma
    periodontitis    atherosclerosis    esophagitis    squamous cell carcinoma
    hypoxia    hepatitis    neuronitis


    KCNK2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for KCNK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acidosis 48.7 1 15090259 (1)

    Genetic Association Database (GAD): KCNK2
    Human Genome Epidemiology (HuGE) Navigator: KCNK2 (11 documents)

    Export disorders for KCNK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNK2 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with KCNK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR(*)D Study. (PubMed id 18288090)1, 4, 9 Perlis R.H....Smoller J.W. (2008)
    2. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PubMed id 9721223)1, 3, 9 Lesage F. and Lazdunski M. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Variation in TREK1 gene linked to depression-resistan t phenotype is associated with potentiated neural responses to rewards in human s. (PubMed id 19621370)1, 4 Dillon D.G....Pizzagalli D.A. (2009)
    6. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    7. Support for the involvement of the KCNK2 gene in majo r depressive disorder and response to antidepressant treatment. (PubMed id 19741570)1, 4 Liou Y.J....Hong C.J. (2009)
    8. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    9. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PubMed id 18676988)1, 4 Nyholt D.R....Palotie A. (2008)
    10. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3776 HGNC: 6277 AceView: KCNK2 Ensembl:ENSG00000082482 euGenes: HUgn3776
    ECgene: KCNK2 Kegg: 3776 H-InvDB: KCNK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNK2 gene:
    Search GeneIP for patents involving KCNK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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