Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK2 Gene

Aliases for KCNK2 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 2 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 2 2 3
  • Outward Rectifying Potassium Channel Protein TREK-1 3 4
  • Two Pore Domain Potassium Channel TREK-1 3 4
  • Two Pore Potassium Channel TPKC1 3 4
  • TREK-1 K(+) Channel Subunit 3 4
  • TREK1 3 4
  • TREK 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 2 3
  • Potassium Channel Subfamily K Member 2 Variant 1 3
  • Potassium Channel Subfamily K Member 2 Variant 2 3
  • Tandem-Pore-Domain Potassium Channel TREK-1 3
  • Potassium Channel, Subfamily K, Member 2 2
  • Potassium Channel Subfamily K Member 2 3
  • TWIK-Related Potassium Channel 1 3
  • Two-Pore Potassium Channel 1 3
  • K2P2.1 Potassium Channel 3
  • HTREK-1c 3
  • HTREK-1e 3
  • K2p2.1 3
  • TREK-1 3
  • TPKC1 3

External Ids for KCNK2 Gene

Previous GeneCards Identifiers for KCNK2 Gene

  • GC01P213914
  • GC01P211077
  • GC01P211795
  • GC01P212313
  • GC01P211645
  • GC01P213245
  • GC01P215178
  • GC01P185853

Summaries for KCNK2 Gene

Entrez Gene Summary for KCNK2 Gene

  • This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK2 Gene

KCNK2 (Potassium Two Pore Domain Channel Subfamily K Member 2) is a Protein Coding gene. Diseases associated with KCNK2 include Dentin Sensitivity. Among its related pathways are Sweet Taste Signaling and Cardiac conduction. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNK10.

UniProtKB/Swiss-Prot for KCNK2 Gene

  • Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).

  • Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Tocris Summary for KCNK2 Gene

Gene Wiki entry for KCNK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK2 Gene

Genomics for KCNK2 Gene

Regulatory Elements for KCNK2 Gene

Enhancers for KCNK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F215024 0.6 FANTOM5 19.9 +22.5 22476 0.3 JUND KCNK2 GC01M215002 GC01P215194
GH01F214967 0.6 ENCODE 11 -34.6 -34564 1.0 JUND KCNK2 ENSG00000223869
GH01F215051 0.3 FANTOM5 10.3 +49.4 49403 0.4 KCNK2 GC01M215002 GC01P215194
GH01F215052 0.2 ENCODE 10.3 +50.3 50254 0.2 KCNK2 GC01M215002 GC01P215194
GH01F215055 0.2 ENCODE 10.3 +53.1 53128 0.3 KCNK2 GC01M215002 GC01P215194
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KCNK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK2 Gene

Chromosome:
1
Start:
215,002,639 bp from pter
End:
215,237,093 bp from pter
Size:
234,455 bases
Orientation:
Plus strand

Genomic View for KCNK2 Gene

Genes around KCNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK2 Gene

Proteins for KCNK2 Gene

  • Protein details for KCNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95069-KCNK2_HUMAN
    Recommended name:
    Potassium channel subfamily K member 2
    Protein Accession:
    O95069
    Secondary Accessions:
    • A1Z1V3
    • A8K618
    • B2RCS4
    • B7ZL56
    • D3DTA5
    • Q5DP47
    • Q5DP48
    • Q9NRT2
    • Q9UNE3

    Protein attributes for KCNK2 Gene

    Size:
    426 amino acids
    Molecular mass:
    47093 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Ref.13). Heterodimer with KCNK1; disulfide-linked (By similarity). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:26642364).
    Miscellaneous:
    • Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.

    Three dimensional structures from OCA and Proteopedia for KCNK2 Gene

    Alternative splice isoforms for KCNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK2 Gene

Post-translational modifications for KCNK2 Gene

  • Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
  • Glycosylation at Asn 110 and Asn 134
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for KCNK2
  • Santa Cruz Biotechnology (SCBT) Antibodies for KCNK2

No data available for DME Specific Peptides for KCNK2 Gene

Domains & Families for KCNK2 Gene

Gene Families for KCNK2 Gene

Graphical View of Domain Structure for InterPro Entry

O95069

UniProtKB/Swiss-Prot:

KCNK2_HUMAN :
  • The C-terminal region of isoform 4 mediates its intracellular retention.
Domain:
  • The C-terminal region of isoform 4 mediates its intracellular retention.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK2: view

Function for KCNK2 Gene

Molecular function for KCNK2 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 2
UniProtKB/Swiss-Prot Function:
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Gene Ontology (GO) - Molecular Function for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0015271 outward rectifier potassium channel activity ISS --
GO:0022841 potassium ion leak channel activity ISS --
genes like me logo Genes that share ontologies with KCNK2: view
genes like me logo Genes that share phenotypes with KCNK2: view

Animal Models for KCNK2 Gene

MGI Knock Outs for KCNK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK2 Gene

Localization for KCNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK2 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.
Isoform 4: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK2 Gene COMPARTMENTS Subcellular localization image for KCNK2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with KCNK2: view

Pathways & Interactions for KCNK2 Gene

genes like me logo Genes that share pathways with KCNK2: view

Gene Ontology (GO) - Biological Process for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003231 cardiac ventricle development IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KCNK2: view

No data available for SIGNOR curated interactions for KCNK2 Gene

Drugs & Compounds for KCNK2 Gene

(15) Drugs for KCNK2 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, antagonist 2
Riluzole Approved, Investigational Pharma Activator, blocker Sodium channel protein inhibitor 63
Dofetilide Approved Pharma Pore Blocker, blocker, Target, inhibitor 14
Dronedarone Approved Pharma Target, inhibitor 0
Gliquidone Approved Pharma 5

(2) Additional Compounds for KCNK2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK2 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3

(3) ApexBio Compounds for KCNK2 Gene

Compound Action Cas Number
BL 1249 Putative activator of potassium TREK-1 18200-13-0
Gliquidone 33342-05-1
Tolbutamide CAMP inhibitor 64-77-7
genes like me logo Genes that share compounds with KCNK2: view

Transcripts for KCNK2 Gene

Unigene Clusters for KCNK2 Gene

Potassium channel, subfamily K, member 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for KCNK2 Gene

GeneLoc Exon Structure for
KCNK2
ECgene alternative splicing isoforms for
KCNK2

Expression for KCNK2 Gene

mRNA expression in normal human tissues for KCNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK2 Gene

This gene is overexpressed in Adrenal Gland (x10.8).

NURSA nuclear receptor signaling pathways regulating expression of KCNK2 Gene:

KCNK2

SOURCE GeneReport for Unigene cluster for KCNK2 Gene:

Hs.497745

mRNA Expression by UniProt/SwissProt for KCNK2 Gene:

O95069-KCNK2_HUMAN
Tissue specificity: Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
genes like me logo Genes that share expression patterns with KCNK2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNK2 Gene

Orthologs for KCNK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK2 34 35
  • 99.92 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNK2 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK2 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK2 34 35
  • 91.73 (n)
dog
(Canis familiaris)
Mammalia KCNK2 34 35
  • 90.66 (n)
mouse
(Mus musculus)
Mammalia Kcnk2 34 16 35
  • 88.97 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk2 34
  • 88.81 (n)
chicken
(Gallus gallus)
Aves KCNK2 34 35
  • 83.65 (n)
lizard
(Anolis carolinensis)
Reptilia KCNK2 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk2a 35
  • 73 (a)
OneToMany
LOC559728 34
  • 71.37 (n)
kcnk2b 35
  • 67 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6929 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for KCNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK2 Gene

ENSEMBL:
Gene Tree for KCNK2 (if available)
TreeFam:
Gene Tree for KCNK2 (if available)

Paralogs for KCNK2 Gene

Paralogs for KCNK2 Gene

genes like me logo Genes that share paralogs with KCNK2: view

Variants for KCNK2 Gene

Sequence variations from dbSNP and Humsavar for KCNK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10127521 -- 215,123,712(+) TCAAA(A/T)GATGT intron-variant
rs10127611 -- 215,125,446(+) ATGTA(A/G)ATGTC intron-variant
rs10127656 -- 215,123,618(+) ACCCC(A/G)TTTTC intron-variant
rs10127736 -- 215,125,602(+) gagat(C/G)gggga intron-variant
rs1015244 -- 215,197,227(+) TCAAA(C/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK2 Gene

Variant ID Type Subtype PubMed ID
dgv24n21 CNV loss 19592680
esv1046148 CNV deletion 17803354
esv1227395 CNV insertion 17803354
esv2722695 CNV deletion 23290073
esv2722706 CNV deletion 23290073
esv2760086 CNV loss 21179565
esv3004990 CNV deletion 24192839
esv3307846 CNV mobile element insertion 20981092
esv3308609 CNV mobile element insertion 20981092
esv3337050 CNV insertion 20981092
esv3360711 CNV insertion 20981092
esv3388970 CNV insertion 20981092
esv3398251 CNV insertion 20981092
esv3421442 CNV insertion 20981092
esv3546478 CNV deletion 23714750
esv3588798 CNV loss 21293372
esv3588799 CNV loss 21293372
esv3588800 CNV loss 21293372
esv3588803 CNV loss 21293372
esv3588804 CNV loss 21293372
nsv1119758 CNV deletion 24896259
nsv1143476 CNV deletion 24896259
nsv160908 CNV deletion 16902084
nsv549182 CNV loss 21841781
nsv952099 CNV deletion 24416366

Variation tolerance for KCNK2 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK2 Gene

Disorders for KCNK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search KCNK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNK2

Genetic Association Database (GAD)
KCNK2
Human Genome Epidemiology (HuGE) Navigator
KCNK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK2
genes like me logo Genes that share disorders with KCNK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK2 Gene

Publications for KCNK2 Gene

  1. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. (PMID: 18288090) Perlis R.H. … Smoller J.W. (Neuropsychopharmacology 2008) 3 22 46 64
  2. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PMID: 9721223) Lesage F. … Lazdunski M. (Genomics 1998) 2 3 22 64
  3. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. (PMID: 24196565) Rinne S. … Preisig-Muller R. (Pflugers Arch. 2014) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for KCNK2 Gene

Sources for KCNK2 Gene

Content
Loading form....