KCNK2 Gene

Aliases
for KCNK2 gene

Previous GC identifers: GC01P213914 GC01P211077 GC01P211795 GC01P212313 GC01P211645 GC01P213245 GC01P185853

Summaries
for KCNK2 gene

Genomic Views
for KCNK2 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_167186.1  

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNK2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK2

KCNK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P215178:  view genomic region     (about GC identifiers)

Proteins
for KCNK2 gene

Explore the universe of human proteins at neXtProt for KCNK2: NX_O95069

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): KCNK2 OriGene Custom Protein Services for KCNK2
	GenScript Custom Purified and Recombinant Proteins Services for KCNK2
	Novus Biologicals KCNK2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KCNK2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNK2
	Browse R&D Systems for Antibodies
	OriGene Antibodies: KCNK2 OriGene Custom Antibody Services for KCNK2
	GenScript Custom Superior Antibodies Services for KCNK2
	Novus Biologicals KCNK2 Antibodies
	Search for Antibodies for KCNK2 at Abcam
	Uscn Antibodies for KCNK2
	ThermoFisher Antibodies for KCNK2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KCNK2

Protein Domains /
Families
for KCNK2 gene

ProtoNet protein and cluster: O95069

Function
for KCNK2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): KCNK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNK2
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNK2 (see all 24):
		hsa-miR-3910 hsa-miR-513a-5p hsa-miR-128 hsa-miR-1285 hsa-miR-132 hsa-miR-888* hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: KCNK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK2 (see all 6) OriGene shRNA RFP: KCNK2 OriGene siRNA: KCNK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNK2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KCNK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK2 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): KCNK2 (NM_001017424)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNK2
		Search LifeMap BioReagents cell lines for KCNK2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Kcnk2)

Pathways & Interactions
for KCNK2 gene

	Super-pathway	contained gene-specific pathways
1	Sweet Taste Signaling	Sweet Taste Signaling 1.00 Bitter Taste Signaling 0.44 Melatonin Signaling 0.72 Sperm Motility 0.36 Cellular Effects of Sildenafil 0.46
2	Activation of cAMP-Dependent PKA	Activation of cAMP-Dependent PKA 1.00 PKA Signaling 0.56 cAMP Pathway 0.77
3	Neuropathic Pain-Signaling in Dorsal Horn Neurons	Neuropathic Pain-Signaling in Dorsal Horn Neurons 1.00 Cholera Infection 0.40 Aldosterone Signaling in Epithelial Cells 0.47
4	Potassium Channels	Potassium Channels 1.00 Potassium transporters: outward current 0.42
5	Hepatic ABC Transporters	Hepatic ABC Transporters 1.00 MODY (Maturity-Onset Diabetes of Young) 0.41

1 EMD Millipore Pathway for KCNK2

Potassium transporters- outward current

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK2

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

4        Reactome Pathways for KCNK2

	Potassium Channels
	Neuronal System
	TWIK related potassium channel (TREK)
	Tandem pore domain potassium channels

1         Kegg Pathway  (Kegg details for KCNK2)

Gastric acid secretion

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KCNK2 gene

Transcripts
for KCNK2 gene

Expression
for KCNK2 gene

KCNK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAAACTGT

Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK2

Orthologs
for KCNK2 gene

Paralogs
for KCNK2 gene

Paralogs for KCNK2 gene

KCNK15²  KCNK5²  KCNK16²  KCNK3²  KCNK12²  KCNK9²  KCNK6²  KCNK18²  

KCNK17²  KCNK10²  KCNK7²  KCNK4²  KCNK13²  KCNK1²  

6 SIMAP similar genes for KCNK2 using alignment to 7 protein entries:     KCNK2_HUMAN (see all proteins):

KCNK16    KCNK4    KCNK10    KCNK17    KCNK1    KCNK6

KCNK2 for paralogs           About GeneDecksing

Genomic Variants
for KCNK2 gene

10/3840 NCBI SNPs in KCNK2 are shown (see all 3840)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs121342081,2	H,	--	215176935(+)	AACTCC/TGCGAC	1	--	us2k1		5		NS EA NA	538
rs1903509251,2		--	215176938(+)	TCCGCA/GACCTG	1	--	us2k1		0	--	--	--	--
rs1822854641,2		--	215176999(+)	AGTCCA/CGCTAA	1	--	us2k1		0	--	--	--	--
rs1877384811,2		--	215177012(+)	CTCACA/CCTTAA	1	--	us2k1		0	--	--	--	--
rs1437134141,2		--	215177203(+)	TAACAC/TAGGAG	1	--	us2k1		0	--	--	--	--
rs1932141011,2		--	215177225(+)	CATTAA/GCCTCA	1	--	us2k1		0	--	--	--	--
rs1382577401,2		--	215177274(+)	ATTCCC/TGACAT	1	--	us2k1		0	--	--	--	--
rs1438544471,2		--	215177277(+)	CCCGAC/TATGAC	1	--	us2k1		0	--	--	--	--
rs1838914941,2		--	215177310(+)	CACTTC/TCTCTG	1	--	us2k1		0	--	--	--	--
rs1885552331,2		--	215177393(+)	TTTCCA/CTCAGT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNK2 (215178885 - 215410436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KCNK2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK2

DNA2.0 Custom Variant and Variant Library Synthesis for KCNK2

Disorders / Diseases
for KCNK2 gene

14 diseases for KCNK2

1 Novoseek disease relationship for KCNK2 gene    About this table

Publications
for KCNK2 gene

PubMed articles for KCNK2 gene, integrated from 9 sources (see all 72): (articles sorted by number of sources associating them with KCNK2)

Utopia: connect your pdf to the dynamic world of online information

1. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PubMed id 9721223)^{1, 3, 9} Lesage F. and Lazdunski M. (1998)
2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)^{1, 3} Goldstein S.A....Rajan S. (2005)
3. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. (PubMed id 10784345)^{1, 2} Meadows H.J.... Chapman C.G. (2000)
4. Inhalational anesthetics activate two-pore-domain background K+ channels. (PubMed id 10321245)^{1, 2} Patel A.J.... Lazdunski M. (1999)
5. Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine. (PubMed id 15685212)^{1, 9} Kennard L.E....Mathie A. (2005)
6. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. (PubMed id 9003761)^{1, 9} Fink M....Lazdunski M. (1996)
7. Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR(*)D Study. (PubMed id 18288090)^{1, 9} Perlis R.H....Smoller J.W. (2008)
8. Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. (PubMed id 16006563)^{1, 9} Murbartian J....Bayliss D.A. (2005)
9. Expression of the mechanosensitive 2PK+ channel TREK-1 in human osteoblasts. (PubMed id 16250016)^{1, 9} Hughes S....El Haj A.J. (2006)
10. Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion. (PubMed id 18854423)^{1, 9} Brenner T. and O'Shaughnessy K.M. (2008)

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Products
for KCNK2 gene