Aliases for KCNK18 Gene
External Ids for KCNK18 Gene
Previous GeneCards Identifiers for KCNK18 Gene
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]
GeneCards Summary for KCNK18 Gene
KCNK18 (Potassium Channel, Two Pore Domain Subfamily K, Member 18) is a Protein Coding gene. Diseases associated with KCNK18 include migraine with or without aura, susceptibility 13 and migraine, with or without aura 13. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity.
UniProtKB/Swiss-Prot for KCNK18 Gene
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).