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Aliases for KCNK18 Gene

Aliases for KCNK18 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 18 2 3
  • TRESK 3 4 6
  • TRIK 3 4 6
  • TWIK-Related Spinal Cord Potassium Channel 3 4
  • Potassium Channel, Subfamily K, Member 18 2 3
  • TWIK-Related Individual Potassium Channel 3 4
  • MGR13 3 6
  • Potassium Channel Subfamily K Member 18 3
  • TWIK Related Spinal Cord K+ Channel 2
  • TWIK-Related Spinal Cord K+ Channel 3
  • TWIK-Related Individual K+ Channel 3
  • K2p18.1 3
  • TRESK-2 3
  • TRESK2 3

External Ids for KCNK18 Gene

Summaries for KCNK18 Gene

Entrez Gene Summary for KCNK18 Gene

  • Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]

GeneCards Summary for KCNK18 Gene

KCNK18 (Potassium Channel, Two Pore Domain Subfamily K, Member 18) is a Protein Coding gene. Diseases associated with KCNK18 include migraine, with or without aura 13 and migraine with aura. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include potassium channel activity and outward rectifier potassium channel activity.

UniProtKB/Swiss-Prot for KCNK18 Gene

  • Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).

Gene Wiki entry for KCNK18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK18 Gene

Genomics for KCNK18 Gene

Genomic Location for KCNK18 Gene

Start:
117,197,489 bp from pter
End:
117,210,299 bp from pter
Size:
12,811 bases
Orientation:
Plus strand

Genomic View for KCNK18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK18 Gene

Regulatory Elements for KCNK18 Gene

Proteins for KCNK18 Gene

  • Protein details for KCNK18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z418-KCNKI_HUMAN
    Recommended name:
    Potassium channel subfamily K member 18
    Protein Accession:
    Q7Z418
    Secondary Accessions:
    • Q5SQQ8

    Protein attributes for KCNK18 Gene

    Size:
    384 amino acids
    Molecular mass:
    43671 Da
    Quaternary structure:
    • Interacts with calcineurin. Interacts with YWHAH, in a phosphorylation-dependent manner.
    Miscellaneous:
    • In contrast to its mouse ortholog, it is not regulated by extracellular protons

neXtProt entry for KCNK18 Gene

Proteomics data for KCNK18 Gene at MOPED

Post-translational modifications for KCNK18 Gene

  • N-glycosylated.
  • Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn70

Other Protein References for KCNK18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK18 Gene

Domains for KCNK18 Gene

Gene Families for KCNK18 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

Suggested Antigen Peptide Sequences for KCNK18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z418

UniProtKB/Swiss-Prot:

KCNKI_HUMAN
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.:
    • Q7Z418
genes like me logo Genes that share domains with KCNK18: view

Function for KCNK18 Gene

Molecular function for KCNK18 Gene

UniProtKB/Swiss-Prot Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).

Gene Ontology (GO) - Molecular Function for KCNK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity TAS --
GO:0005515 protein binding --
GO:0015269 calcium-activated potassium channel activity IEA --
GO:0015271 outward rectifier potassium channel activity IDA 12754259
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK18: view

Phenotypes for KCNK18 Gene

MGI mutant phenotypes for KCNK18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with KCNK18: view

miRNA for KCNK18 Gene

miRTarBase miRNAs that target KCNK18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNK18 Gene

Localization for KCNK18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK18 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK18 Gene COMPARTMENTS Subcellular localization image for KCNK18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for KCNK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 12754259
genes like me logo Genes that share ontologies with KCNK18: view

Pathways for KCNK18 Gene

genes like me logo Genes that share pathways with KCNK18: view

Pathways by source for KCNK18 Gene

Gene Ontology (GO) - Biological Process for KCNK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IDA 20006580
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0071435 potassium ion export IDA 12754259
GO:0071467 cellular response to pH IDA 12754259
genes like me logo Genes that share ontologies with KCNK18: view

Compounds for KCNK18 Gene

(5) Tocris Compounds for KCNK18 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
Tetraethylammonium chloride Non-selective K+ channel blocker [56-34-8]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [33978-72-2]

(1) IUPHAR Ligand for KCNK18 Gene

Ligand Type Action Affinity Pubmed IDs
arachidonic acid Activator Potentiation

(3) Novoseek inferred chemical compound relationships for KCNK18 Gene

Compound -log(P) Hits PubMed IDs
potassium 51.3 5
arachidonic acid 42 2
calcium 8.67 7
genes like me logo Genes that share compounds with KCNK18: view

Transcripts for KCNK18 Gene

mRNA/cDNA for KCNK18 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK18 Gene

No ASD Table

Relevant External Links for KCNK18 Gene

GeneLoc Exon Structure for
KCNK18
ECgene alternative splicing isoforms for
KCNK18

Expression for KCNK18 Gene

mRNA expression in normal human tissues for KCNK18 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK18 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (9.4), Brain - Caudate (basal ganglia) (8.7), and Brain - Hypothalamus (8.5).

SOURCE GeneReport for Unigene cluster for KCNK18 Gene Hs.449650

mRNA Expression by UniProt/SwissProt for KCNK18 Gene

Q7Z418-KCNKI_HUMAN
Tissue specificity: Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.
genes like me logo Genes that share expressions with KCNK18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KCNK18 Gene

Orthologs for KCNK18 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK18 35
  • 98.52 (n)
  • 97.13 (a)
KCNK18 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK18 35
  • 78.42 (n)
  • 73.42 (a)
KCNK18 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK18 35
  • 79.35 (n)
  • 74.54 (a)
KCNK18 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk18 35
  • 73.71 (n)
  • 68.72 (a)
Kcnk18 16
Kcnk18 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk18 35
  • 73.84 (n)
  • 70.3 (a)
chicken
(Gallus gallus)
Aves KCNK18 35
  • 56.49 (n)
  • 50.81 (a)
KCNK18 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK18 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486306 35
  • 51.18 (n)
  • 43.27 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnk18 35
  • 48.67 (n)
  • 39.39 (a)
kcnk18 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10864 36
  • 19 (a)
OneToMany
CG1688 36
  • 10 (a)
OneToMany
CG34396 36
  • 8 (a)
OneToMany
CG42340 36
  • 15 (a)
OneToMany
CG42594 36
  • 8 (a)
OneToMany
CG43155 36
  • 19 (a)
OneToMany
CG8713 36
  • 19 (a)
OneToMany
CG9194 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-23 36
  • 10 (a)
OneToMany
twk-10 36
  • 19 (a)
OneToMany
twk-11 36
  • 5 (a)
OneToMany
twk-12 36
  • 10 (a)
OneToMany
twk-13 36
  • 14 (a)
OneToMany
twk-16 36
  • 10 (a)
OneToMany
twk-17 36
  • 11 (a)
OneToMany
twk-18 36
  • 17 (a)
OneToMany
twk-2 36
  • 5 (a)
OneToMany
twk-21 36
  • 13 (a)
OneToMany
twk-22 36
  • 10 (a)
OneToMany
twk-23 36
  • 16 (a)
OneToMany
twk-24 36
  • 14 (a)
OneToMany
twk-25 36
  • 10 (a)
OneToMany
twk-26 36
  • 14 (a)
OneToMany
twk-28 36
  • 15 (a)
OneToMany
twk-29 36
  • 14 (a)
OneToMany
twk-3 36
  • 19 (a)
OneToMany
twk-30 36
  • 11 (a)
OneToMany
twk-31 36
  • 7 (a)
OneToMany
twk-32 36
  • 12 (a)
OneToMany
twk-33 36
  • 12 (a)
OneToMany
twk-34 36
  • 13 (a)
OneToMany
twk-35 36
  • 13 (a)
OneToMany
twk-36 36
  • 12 (a)
OneToMany
twk-37 36
  • 15 (a)
OneToMany
twk-39 36
  • 12 (a)
OneToMany
twk-4 36
  • 19 (a)
OneToMany
twk-40 36
  • 19 (a)
OneToMany
twk-42 36
  • 14 (a)
OneToMany
twk-43 36
  • 12 (a)
OneToMany
twk-44 36
  • 9 (a)
OneToMany
twk-45 36
  • 14 (a)
OneToMany
twk-48 36
  • 22 (a)
OneToMany
twk-7 36
  • 14 (a)
OneToMany
twk-8 36
  • 11 (a)
OneToMany
twk-9 36
  • 14 (a)
OneToMany
unc-58 36
  • 13 (a)
OneToMany
Species with no ortholog for KCNK18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK18 Gene

ENSEMBL:
Gene Tree for KCNK18 (if available)
TreeFam:
Gene Tree for KCNK18 (if available)

Paralogs for KCNK18 Gene

No data available for Paralogs for KCNK18 Gene

Variants for KCNK18 Gene

Sequence variations from dbSNP and Humsavar for KCNK18 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs363306 -- 117,201,019(+) TCCGA(C/T)CACCG intron-variant
rs363307 -- 117,202,044(+) CAGGA(G/T)CGTGG intron-variant
rs363308 -- 117,202,231(+) CTGTG(G/T)AATCT intron-variant
rs363309 -- 117,202,392(+) AAACC(A/G)CAAGG intron-variant
rs363310 -- 117,202,553(+) CACAG(C/T)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK18 Gene

Variant ID Type Subtype PubMed ID
nsv832002 CNV Gain+Loss 17160897
nsv896038 CNV Gain 21882294
esv34075 CNV Loss 18971310

Relevant External Links for KCNK18 Gene

HapMap Linkage Disequilibrium report
KCNK18
Human Gene Mutation Database (HGMD)
KCNK18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK18 Gene

Disorders for KCNK18 Gene

(1) OMIM Diseases for KCNK18 Gene (613655)

UniProtKB/Swiss-Prot

KCNKI_HUMAN
  • Migraine with or without aura 13 (MGR13) [MIM:613656]: A form of migraine transmitted in an autosomal dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO:0000269 PubMed:20871611}. Note=The disease is caused by mutations affecting the gene represented in this entry. Susceptibility to migraine has been shown to be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family. Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine.

(1) University of Copenhagen DISEASES for KCNK18 Gene

Relevant External Links for KCNK18

Genetic Association Database (GAD)
KCNK18
Human Genome Epidemiology (HuGE) Navigator
KCNK18
genes like me logo Genes that share disorders with KCNK18: view

Publications for KCNK18 Gene

  1. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. (PMID: 12754259) Sano Y. … Furuichi K. (J. Biol. Chem. 2003) 3 4 23
  2. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. (PMID: 14981085) CzirjA!k G. … Enyedi P. (J. Biol. Chem. 2004) 3 23
  3. TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways. (PMID: 20215114) CzirjA!k G. … Enyedi P. (J. Biol. Chem. 2010) 3 23
  4. N-linked glycosylation determines cell surface expression of two- pore-domain K+ channel TRESK. (PMID: 20006580) Egenberger B. … Doring F. (Biochem. Biophys. Res. Commun. 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for KCNK18 Gene

Sources for KCNK18 Gene

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