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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK18 Gene

protein-coding   GIFtS: 56
GCID: GC10P118947

Potassium Channel, Subfamily K, Member 18

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 181 2     K2p18.12
TRESK2 3 5     TRESK-22
TRIK2 3 5     TRESK22
TWIK-Related Individual Potassium Channel2 3     Potassium Channel Subfamily K Member 182
TWIK-Related Spinal Cord Potassium Channel2 3     TWIK-Related Individual K+ Channel2
MGR132 5     TWIK-Related Spinal Cord K+ Channel2
TWIK Related Spinal Cord K+ Channel1     

External Ids:    HGNC: 194391   Entrez Gene: 3385672   Ensembl: ENSG000001867957   OMIM: 6136555   UniProtKB: Q7Z4183   

Export aliases for KCNK18 gene to outside databases

Previous GC identifer: GC10P112584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK18 Gene:
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle
contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily
of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an
outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with
aura.(provided by RefSeq, Jan 2011)

GeneCards Summary for KCNK18 Gene: 
KCNK18 (potassium channel, subfamily K, member 18) is a protein-coding gene. Diseases associated with KCNK18 include migraine with aura, and migraine without aura, and among its related super-pathways are Transmission across Chemical Synapses and Voltage gated Potassium channels. GO annotations related to this gene include outward rectifier potassium channel activity and potassium channel activity.

UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May
function as background potassium channel that sets the resting membrane potential. Channel activity is directly
activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly
activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the
current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring
unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane.
Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in
the somatosensory function with special respect to pain sensation (By similarity)

Gene Wiki entry for KCNK18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK18 gene promoter:
         AP-2rep   AP-1   p300   HTF   NRSF form 1   NRSF form 2   HNF-1A   AREB6   HNF-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK18 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

KCNK18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118947:  view genomic region     (about GC identifiers)

Start:
118,957,000 bp from pter      End:
118,969,810 bp from pter
Size:
12,811 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 18  
Size: 384 amino acids; 43671 Da
Subunit: Interacts with calcineurin (By similarity). Interacts with YWHAH, in a phosphorylation-dependent manner
(By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: In contrast to its mouse ortholog, it is not regulated by extracellular protons
Secondary accessions: Q5SQQ8

Explore the universe of human proteins at neXtProt for KCNK18: NX_Q7Z418

Explore proteomics data for KCNK18 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation
    of Ser-264 enhances channel activity (By similarity)
  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z418

  • KCNK18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNK18 Protein Expression
    REFSEQ proteins: NP_862823.1  
    ENSEMBL proteins: 
     ENSP00000334650  
    Reactome Protein details: Q7Z418
    Human Recombinant Protein Products for KCNK18: 
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    Cloud-Clone Corp. Proteins for KCNK18 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC12754259

    KCNK18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P18.1 
    Two-P potassium channels

    2 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry Q7Z418

    ProtoNet protein and cluster: Q7Z418

    2 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    KCNK18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNKI_HUMAN, Q7Z418
    Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May
    function as background potassium channel that sets the resting membrane potential. Channel activity is directly
    activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly
    activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the
    current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring
    unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane.
    Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in
    the somatosensory function with special respect to pain sensation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005267potassium channel activity TAS--
    GO:0005515protein binding ----
    GO:0015269calcium-activated potassium channel activity IEA--
    GO:0015271outward rectifier potassium channel activity IDA12754259
         
    KCNK18 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnk18):
     nervous system 

    KCNK18 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNK18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Neuronal System0.67
    2Potassium Channels
    Potassium Channels0.43
    3Tandem pore domain potassium channels
    Tandem pore domain potassium channels
    4TWIK-related spinal cord K+ channel (TRESK)
    TWIK-related spinal cord K+ channel (TRESK)
    5Potassium transporters: inward current
    Potassium transporters: inward current

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNK18
        Potassium transporters- inward current


    4        Reactome Pathways for KCNK18
        Potassium Channels
    TWIK-related spinal cord K+ channel (TRESK)
    Neuronal System
    Tandem pore domain potassium channels



    KCNK18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK18

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KCNK18 (Q7Z4183 ENSP000003346504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR2P371733, ENSP000003519054I2D: score=1 STRING: ENSP00000351905
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport IDA--
    GO:0007268synaptic transmission TAS--
    GO:0071435potassium ion export IDA12754259
    GO:0071467cellular response to pH IDA12754259

    KCNK18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNK18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNK18 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    1 IUPHAR Ligand for KCNK18 (K2P18.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    arachidonic acid
    InhibitorNone--

    3 Novoseek inferred chemical compound relationships for KCNK18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 51.3 6 17962323 (1), 18568022 (1), 11165377 (1), 14981085 (1) (see all 5)
    arachidonic acid 42 2 12754259 (1), 11165377 (1)
    calcium 8.67 9 14981085 (5), 20215114 (1), 16354767 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNK18 / KCNKI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNK18 gene: 
    NM_181840.1  

    Unigene Cluster for KCNK18:

    Potassium channel, subfamily K, member 18
    Hs.449650
    Unigene Representative Sequence: AB087138
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334549(uc010qsr.2)

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    Additional mRNA sequence: AB087138.1 

    1 DOTS entry:

    DT.100697388 

    2 AceView cDNA sequences:

    NM_181840 AB087138 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNK18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGAGTA
    KCNK18 Expression
    About this image


    See KCNK18 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.449650

    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
    Tissue specificity: Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at
    low levels in spinal cord

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNK18 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk181 , 5 potassium channel, subfamily K, member 181, 5 74.08(n)1
    69.51(a)1
      19 (54.63 cM)5
    3323961  NM_207261.31  NP_997144.11 
     592196485 
    chicken
    (Gallus gallus)
    Aves KCNK181 potassium channel, subfamily K, member 18 56.58(n)
    50.81(a)
      771448  XM_001234728.2  XP_001234729.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK186
    Uncharacterized protein
    45(a)
    1 ↔ 1
    GL343206.1(1477628-1484176)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnk181 potassium channel, subfamily K, member 18 47.62(n)
    39.22(a)
      561821  NM_001190307.1  NP_001177236.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16886
    CG343966
    (see all 8)
    --
    6(a)
    6(a)
    (see all 8)
    many → 1
    many → 1
    (see all 8)
    2R(5653867-5694370)
    2R(16979743-16988961)
    worm
    (Caenorhabditis elegans)
    Secernentea twk-401 Protein TWK-40 50.77(n)
    38.51(a)
      189006  NM_067389.1  NP_499790.1 


    ENSEMBL Gene Tree for KCNK18 (if available)
    TreeFam Gene Tree for KCNK18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 SNPs in KCNK18 are shown (see all 413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0640274
    ----see VAR_0640272 A V mis40--------
    rs566805991,2
    C,F--118955861(+) TATTTG/TCATTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1478771791,2
    C--118959947(+) ACAGC-/TTGCTTTTC
    CTAAAAGCCTT
    TTGCT
    1 -- int10--------
    rs2002509851,2
    C--118959955(+) CTTTTA/CCTAAA 1 -- int10--------
    rs361017401,2
    C--118960325(+) AAAAAA/-CAGAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs722301611,2
    C--118963781(+) AAAAA-/AGAAAA 1 -- int10--------
    rs114090431,2
    C--118968254(+) TTTTT-/T/TT  
            
    TTTTG
    1 -- int1 trp30--------
    rs1132653751,2
    C,F--118968345(+) CTCCCG/AGCTTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs567698961,2
    C--118969992(+) AAAAA-/ACTATC 1 -- ds50010--------
    rs1456109281,2
    --119310722(+) TTTTTC/GTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNK18 (118957000 - 118969810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNK18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34075CNV Loss18971310
    nsv896038CNV Gain21882294
    nsv832002CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): KCNK18
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613655   
    OMIM disorders: 613656  
    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
  • Migraine with or without aura 13 (MGR13) [MIM:613656]: A form of migraine transmitted in an autosomal
    dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral.
    Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of
    the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine
    (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms
    (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as
    blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. Note=The disease
    is caused by mutations affecting the gene represented in this entry. Susceptibility to migraine has been shown to
    be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family.
    Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional
    vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine

  • 8 diseases for KCNK18:    About MalaCards
    migraine with aura    migraine without aura    migraine    headache
    paralysis    alzheimer's disease    alcoholism    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCNK18:
    Migraine

    KCNK18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): KCNK18
    Human Genome Epidemiology (HuGE) Navigator: KCNK18 (2 documents)

    Export disorders for KCNK18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNK18 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with KCNK18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. (PubMed id 12754259)1, 2, 9 Sano Y.... Furuichi K. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. (PubMed id 20871611)1, 2 Lafreniere R.G.... Rouleau G.A. (2010)
    4. N-linked glycosylation determines cell surface expres sion of two-pore-domain K+ channel TRESK. (PubMed id 20006580)1, 2 Egenberger B....DAPring F. (2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    6. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
    7. TRESK background K(+) channel is inhibited by phospho rylation via two distinct pathways. (PubMed id 20215114)1, 9 CzirjA!k G. and Enyedi P. (2010)
    8. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. (PubMed id 14981085)1, 9 Czirjak G....Enyedi P. (2004)
    9. TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. (PubMed id 17962323)2, 9 Dobler T....Doring F. (2007)
    10. TRESK potassium channel in human T lymphoblasts. (PubMed id 23541583)1 Sanchez-Miguel D.S....Dobrovinskaya O. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338567 HGNC: 19439 AceView: TRESK-2 Ensembl:ENSG00000186795 euGenes: HUgn338567
    ECgene: KCNK18 H-InvDB: KCNK18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNK18 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt124.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNK18 gene:
    Search GeneIP for patents involving KCNK18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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