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KCNK18 Gene

protein-coding   GIFtS: 57
GCID: GC10P118947

Potassium Channel, Subfamily K, Member 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel, Subfamily K, Member 181 2     K2p18.12
TRESK2 3 5     TRESK-22
TRIK2 3 5     TRESK22
TWIK-Related Individual Potassium Channel2 3     Potassium Channel Subfamily K Member 182
TWIK-Related Spinal Cord Potassium Channel2 3     TWIK-Related Individual K+ Channel2
MGR132 5     TWIK-Related Spinal Cord K+ Channel2
TWIK Related Spinal Cord K+ Channel1     

External Ids:    HGNC: 194391   Entrez Gene: 3385672   Ensembl: ENSG000001867957   OMIM: 6136555   UniProtKB: Q7Z4183   

Export aliases for KCNK18 gene to outside databases

Previous GC identifer: GC10P112584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNK18 Gene:
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle
contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily
of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an
outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with
aura.(provided by RefSeq, Jan 2011)

GeneCards Summary for KCNK18 Gene:
KCNK18 (potassium channel, subfamily K, member 18) is a protein-coding gene. Diseases associated with KCNK18 include migraine with aura, and migraine, with or without aura 13. GO annotations related to this gene include outward rectifier potassium channel activity and potassium channel activity.

UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May
function as background potassium channel that sets the resting membrane potential. Channel activity is directly
activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly
activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the
current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring
unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane.
Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in
the somatosensory function with special respect to pain sensation (By similarity)

Gene Wiki entry for KCNK18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK18 gene promoter:
         AP-2rep   AP-1   p300   HTF   NRSF form 1   NRSF form 2   HNF-1A   AREB6   HNF-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK18 promoter sequence
   Search Chromatin IP Primers for KCNK18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

KCNK18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P118947:  view genomic region     (about GC identifiers)

Start:
118,957,000 bp from pter      End:
118,969,810 bp from pter
Size:
12,811 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 18  
Size: 384 amino acids; 43671 Da
Subunit: Interacts with calcineurin (By similarity). Interacts with YWHAH, in a phosphorylation-dependent manner
(By similarity)
Miscellaneous: In contrast to its mouse ortholog, it is not regulated by extracellular protons
Secondary accessions: Q5SQQ8

Explore the universe of human proteins at neXtProt for KCNK18: NX_Q7Z418

Explore proteomics data for KCNK18 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation
    of Ser-264 enhances channel activity (By similarity)1
  • N-glycosylated1
  • Glycosylation2 at Asn70
  • Modification sites at PhosphoSitePlus

  • See KCNK18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_862823.1  
    ENSEMBL proteins: 
     ENSP00000334650  
    Reactome Protein details: Q7Z418

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P18.1
    Two-P potassium channels

    2 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z418

    ProtoNet protein and cluster: Q7Z418

    2 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    KCNK18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNKI_HUMAN, Q7Z418
    Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May
    function as background potassium channel that sets the resting membrane potential. Channel activity is directly
    activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly
    activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the
    current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring
    unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane.
    Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in
    the somatosensory function with special respect to pain sensation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005267potassium channel activity TAS--
    GO:0005515protein binding ----
    GO:0015269calcium-activated potassium channel activity IEA--
    GO:0015271outward rectifier potassium channel activity IDA12754259
         
    KCNK18 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnk18):
     nervous system 

    KCNK18 for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-mir-124-3p (MIRT023160)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNKI_HUMAN, Q7Z418: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC12754259

    KCNK18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNK18 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Tandem pore domain potassium channels0.00
    TWIK-related spinal cord K+ channel (TRESK)0.00
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Potassium transporters inward current
    Potassium transporters inward current

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KCNK18
        TWIK-related spinal cord K+ channel (TRESK)



    KCNK18 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNK18
    Interactions:

        Search GeneGlobe Interaction Network for KCNK18

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KCNK18 (Q7Z4183 ENSP000003346504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR2P371733, ENSP000003519054I2D: score=1 STRING: ENSP00000351905
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport IDA--
    GO:0007268synaptic transmission TAS--
    GO:0071435potassium ion export IDA12754259
    GO:0071467cellular response to pH IDA12754259

    KCNK18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNK18 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    1 IUPHAR Ligand for KCNK18 (K2P18.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    arachidonic acid
    InhibitorNone--

    3 Novoseek inferred chemical compound relationships for KCNK18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 51.3 6 17962323 (1), 18568022 (1), 11165377 (1), 14981085 (1) (see all 5)
    arachidonic acid 42 2 12754259 (1), 11165377 (1)
    calcium 8.67 9 14981085 (5), 20215114 (1), 16354767 (1)



    KCNK18 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNK18 gene: 
    NM_181840.1  

    Unigene Cluster for KCNK18:

    Potassium channel, subfamily K, member 18
    Hs.449650
    Unigene Representative Sequence: AB087138
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334549(uc010qsr.2)
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    Additional mRNA sequence: AB087138.1 

    1 DOTS entry:

    DT.100697388 

    2 AceView cDNA sequences:

    AB087138 NM_181840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNK18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGAGTA
    KCNK18 Expression
    About this image

    KCNK18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNK18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449650

    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
    Tissue specificity: Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at
    low levels in spinal cord

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNK18 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk181 , 5 potassium channel, subfamily K, member 181, 5 73.71(n)1
    68.72(a)1
      19 (54.63 cM)5
    3323961  NM_207261.31  NP_997144.11 
     592196485 
    chicken
    (Gallus gallus)
    Aves KCNK181 potassium channel, subfamily K, member 18 56.49(n)
    50.81(a)
      771448  XM_001234728.3  XP_001234729.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK186
    potassium channel, subfamily K, member 18
    46(a)
    1 ↔ 1
    GL343206.1(1477628-1484176)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004863061 potassium channel subfamily K member 18-like 51.18(n)
    43.27(a)
      100486306  XM_002943388.2  XP_002943434.2 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnk181 potassium channel, subfamily K, member 18 48.67(n)
    39.39(a)
      561821  NM_001190307.2  NP_001177236.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425946
    CG343966
    (see all 8)
    --
    8(a)
    8(a)
    (see all 8)
    many → 1
    many → 1
    (see all 8)
    X(4734990-4799908)
    2R(16979743-16988961)
    worm
    (Caenorhabditis elegans)
    Secernentea twk-446
    twk-316
    (see all 38)
    Protein TWK-44 (twk-44) mRNA, complete cds
    Protein TWK-31, isoform b (twk-31) mRNA, complete ...
    (see all 38)
    9(a)
    7(a)
    (see all 38)
    many → 1
    many → 1
    (see all 38)
    X(11622967-11627113) WBGene00006694
    III(11410712-11424663) WBGene00006683


    ENSEMBL Gene Tree for KCNK18 (if available)
    TreeFam Gene Tree for KCNK18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNK18 (see all 413)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs566805991,2
    C,F--118955861(+) TATTTG/TCATTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1478771791,2
    C--118959947(+) ACAGC-/TTGCTTTTC
    CTAAAAGCCTT
    TTGCT
    1 -- int10--------
    rs2002509851,2
    C--118959955(+) CTTTTA/CCTAAA 1 -- int10--------
    rs361017401,2
    C--118960325(+) AAAAAA/-CAGAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs722301611,2
    C--118963781(+) AAAAA-/AGAAAA 1 -- int10--------
    rs114090431,2
    C--118968254(+) TTTTT-/T/TT  
            
    TTTTG
    1 -- int1 trp30--------
    rs1132653751,2
    C,F--118968345(+) CTCCCG/AGCTTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs567698961,2
    C--118969992(+) AAAAA-/ACTATC 1 -- ds50010--------
    rs1456109281,2
    --119310722(+) TTTTTC/GTATTT 1 -- us2k10--------
    rs1134296981,2
    C,F--119310740(+) AGACAG/CGGTTT 1 -- us2k11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for KCNK18 (118957000 - 118969810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNK18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34075CNV Loss18971310
    nsv896038CNV Gain21882294
    nsv832002CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): KCNK18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNK18
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613655   
    OMIM disorders: 613656  
    UniProtKB/Swiss-Prot: KCNKI_HUMAN, Q7Z418
  • Migraine with or without aura 13 (MGR13) [MIM:613656]: A form of migraine transmitted in an autosomal
    dominant pattern. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral.
    Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of
    the cranial arteries. The two major subtypes are common migraine (migraine without aura) and classic migraine
    (migraine with aura). Classic migraine is characterized by recurrent attacks of reversible neurological symptoms
    (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as
    blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. Note=The disease
    is caused by mutations affecting the gene represented in this entry. Susceptibility to migraine has been shown to
    be conferred by a frameshift mutation that segregates with the disorder in a large multigenerational family.
    Migraine was associated with sensitivity to lights, sounds, and smells, as well as nausea and occasional
    vomiting. Triggers included fatigue, alcohol and bright lights. Mutations in KCNK18 are a rare cause of migraine

  • 9 diseases for KCNK18:    
    About MalaCards
    migraine with aura    migraine, with or without aura 13    migraine without aura    migraine
    headache    alzheimer's disease    multiple myeloma    myeloma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCNK18:
    Migraine

    KCNK18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNK18
    Human Genome Epidemiology (HuGE) Navigator: KCNK18 (2 documents)

    Export disorders for KCNK18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNK18 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with KCNK18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. (PubMed id 12754259)1, 2, 9 Sano Y.... Furuichi K. (J. Biol. Chem. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. (PubMed id 20871611)1, 2 Lafreniere R.G.... Rouleau G.A. (Nat. Med. 2010)
    4. N-linked glycosylation determines cell surface expression of two- pore-domain K+ channel TRESK. (PubMed id 20006580)1, 2 Egenberger B.... Doring F. (Biochem. Biophys. Res. Commun. 2010)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
    7. TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways. (PubMed id 20215114)1, 9 CzirjA!k G. and Enyedi P. (J. Biol. Chem. 2010)
    8. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. (PubMed id 14981085)1, 9 CzirjA!k G....Enyedi P. (J. Biol. Chem. 2004)
    9. TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. (PubMed id 17962323)2, 9 Dobler T.... Doring F. (J. Physiol. (Lond.) 2007)
    10. TRESK potassium channel in human T lymphoblasts. (PubMed id 23541583)1 SA!nchez-Miguel D.S....Dobrovinskaya O. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338567 HGNC: 19439 AceView: TRESK-2 Ensembl:ENSG00000186795 euGenes: HUgn338567
    ECgene: KCNK18 H-InvDB: KCNK18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNK18 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/124

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNK18 gene:
    Search GeneIP for patents involving KCNK18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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