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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK17 Gene

protein-coding   GIFtS: 51
GCID: GC06M039266

Potassium Channel, Subfamily K, Member 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 171 2     TWIK-Related Acid-Sensitive K(+) Channel 42 3
TALK22 3 5     TWIK-Related Alkaline PH-Activated K(+) Channel 22 3
TASK42 3 5     K2p17.12
Acid-Sensitive Potassium Channel Protein TASK-42 3     TASK-42
2P Domain Potassium Channel Talk-22 3     Potassium Channel Subfamily K Member 172
TALK-22 3     

External Ids:    HGNC: 144651   Entrez Gene: 898222   Ensembl: ENSG000001247807   OMIM: 6073705   UniProtKB: Q96T543   

Export aliases for KCNK17 gene to outside databases

Previous GC identifers: GC06M039268 GC06M039313 GC06M039374 GC06M038985


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK17 Gene:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P
domains. This channel is an open rectifier which primarily passes outward current under physiological K+
concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for KCNK17 Gene: 
KCNK17 (potassium channel, subfamily K, member 17) is a protein-coding gene. Diseases associated with KCNK17 include prosopagnosia, and maturity-onset diabetes of the young, and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated ion channel activity and potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents

Gene Wiki entry for KCNK17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK17 gene promoter:
         RFX1   Nkx6-1   Pbx1a   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK17 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21

KCNK17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK17 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M039266:  view genomic region     (about GC identifiers)

Start:
39,266,777 bp from pter      End:
39,282,329 bp from pter
Size:
15,553 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 17  
Size: 332 amino acids; 36895 Da
Subunit: Homodimer (Potential)
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by
quinine and isoflurane
Sequence caution: Sequence=AAK28551.1; Type=Frameshift; Positions=260;
Secondary accessions: E9PB46 Q5TCF4 Q8TAW4 Q9BXD1 Q9H592
Alternative splicing: 2 isoforms:  Q96T54-3   Q96T54-4   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for KCNK17: NX_Q96T54

Explore proteomics data for KCNK17 at MOPED 

KCNK17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KCNK17 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001128583.1  NP_113648.2  

ENSEMBL proteins: 
 ENSP00000362328   ENSP00000401271  
Reactome Protein details: Q96T54
Human Recombinant Protein Products for KCNK17: 
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Cloud-Clone Corp. Proteins for KCNK17 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016020membrane NAS--
GO:0016021integral to membrane IEA--

KCNK17 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for KCNK17


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KCN: Potassium channels
KCNK: Voltage-gated ion channels / Potassium channels, Two-P

IUPHAR Guide to PHARMACOLOGY protein family classification: K2P17.1 
Two-P potassium channels

4 InterPro protein domains:
 IPR003280 2pore_dom_K_chnl
 IPR022306 2pore_dom_K_chnl_TASK/TWIK
 IPR003092 2pore_dom_K_chnl_TASK
 IPR013099 Ion_trans_2

Graphical View of Domain Structure for InterPro Entry Q96T54

ProtoNet protein and cluster: Q96T54

3 Blocks protein domains:
IPB003092 TASK K+ channel signature
IPB003280 Two pore domain K+ channel signature
IPB013099 Ion transport 2


UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54
Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


KCNK17 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCNKH_HUMAN, Q96T54
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005244voltage-gated ion channel activity IEA--
GO:0005267potassium channel activity IDA11248242
     
KCNK17 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for KCNK17:
 Decreased influenza A/WSN/33 r 

Animal Models:
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miRNA
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Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK17


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KCNK17 About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Sweet Taste Signaling
Sweet Taste Signaling0.72
Bitter Taste Signaling0.44
Melatonin Signaling0.72
Sperm Motility0.37
Cellular Effects of Sildenafil0.46
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
PKA Signaling0.56
cAMP Pathway0.77
3Neuropathic Pain-Signaling in Dorsal Horn Neurons
Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
Cholera Infection0.40
Aldosterone Signaling in Epithelial Cells0.47
4Hepatic ABC Transporters
Hepatic ABC Transporters0.41
MODY (Maturity-Onset Diabetes of Young)0.41
5Transmission across Chemical Synapses
Neuronal System0.67

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK17 (see all 13)
    Cholera Infection
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Hepatic ABC Transporters
PKA Signaling
Sweet Taste Signaling

4        Reactome Pathways for KCNK17
    Potassium Channels
TWIK-related alkaline pH activated K+ channel (TALK)
Neuronal System
Tandem pore domain potassium channels



KCNK17 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK17

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006813potassium ion transport IDA11248242
GO:0007268synaptic transmission TAS--
GO:0071805potassium ion transmembrane transport ----

KCNK17 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNK17 available from Tocris Bioscience    About this table
CompoundAction CAS #
Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

Search CenterWatch for drugs/clinical trials and news about KCNK17 / KCNKH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNK17 gene (2 alternative transcripts): 
NM_001135111.1  NM_031460.3  

Unigene Cluster for KCNK17:

Potassium channel, subfamily K, member 17
Hs.162282  [show with all ESTs]
Unigene Representative Sequence: NM_001135111
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373231(uc003ooo.3) ENST00000453413(uc003oop.3) ENST00000503878

miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate KCNK17:
hsa-miR-647
SwitchGear 3'UTR luciferase reporter plasmidKCNK17 3' UTR sequence
Inhib. RNA
Products:
     
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK17

Additional mRNA sequence: 

AF339912.1 AF358910.1 AK310582.1 AK315273.1 AY358853.1 BC025726.1 EU978944.1 

3 DOTS entries:

DT.100672954  DT.100775527  DT.95360336 

24/28 AceView cDNA sequences (see all 28):

AY358853 CR613884 BQ272607 BC025726 AF358910 CR622971 BQ267373 CR626629 
NM_031460 AI740592 CA425995 BX355808 AF339912 BX355809 AA553991 BX346190 
BI838440 BF352053 BX398164 BX346189 BI524751 BI524180 BX104341 BQ025346 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNK17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KCNK17 Expression
About this image


See KCNK17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNK17

SOURCE GeneReport for Unigene cluster: Hs.162282
    SABiosciences Custom PCR Arrays for KCNK17
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCNK17 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia KCNK176
potassium channel, subfamily K, member 17
67(a)
1 ↔ 1
12(8210454-8232093)
chicken
(Gallus gallus)
Aves KCNK171 potassium channel, subfamily K, member 17 63.09(n)
60.37(a)
  421423  XM_419477.2  XP_419477.2 
lizard
(Anolis carolinensis)
Reptilia KCNK176
--
--
51(a)
39(a)
1 ↔ 1
possible ortholog
1(246637033-246674308)
GL343261.1(1886624-1896458)
zebrafish
(Danio rerio)
Actinopterygii KCNK176
potassium channel, subfamily K, member 17
36(a)
1 ↔ 1
17(48892256-48898649)


ENSEMBL Gene Tree for KCNK17 (if available)
TreeFam Gene Tree for KCNK17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KCNK17 gene
KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  
KCNK102  KCNK72  KCNK42  KCNK132  KCNK12  
4 SIMAP similar genes for KCNK17 using alignment to 2 protein entries:     KCNKH_HUMAN (see all proteins):
KCNK16    KCNK2    KCNK6    KCNK4

KCNK17 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/447 SNPs in KCNK17 are shown (see all 447)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0323624
----see VAR_0323622 S G mis40--------
rs590868351,2
C--38997317(+) AGATG-/CACACACACA/C
ACACACACACACACA
CACAC
2 -- int11NA 2
rs1412242951,2
--39266320(+) ACCACG/TGTGTT 2 -- ds50010--------
rs132077321,2
C--39266339(+) TCTTAG/ATAGCA 2 -- ds50011Minor allele frequency- A:0.00NA 2
rs1920343341,2
--39266425(+) TCAAAC/TGCAGT 2 -- ds50010--------
rs1835989631,2
--39266437(+) GGGCAA/GGGTAA 2 -- ds50010--------
rs341025221,2
C,F--39266479(+) TTTTCT/CGTGGT 2 -- ds50013Minor allele frequency- C:0.31NA EA 242
rs1160723481,2
F--39266523(+) GGACTG/AAGACC 2 -- ds50011Minor allele frequency- A:0.01NA 120
rs1508765351,2
C--39266626(+) TCCAGA/CGTTCA 2 -- ds50010--------
rs28150671,2
C,F,A,H--39266636(+) AATCCA/GTTCTT 2 -- ds500134Minor allele frequency- N:0.00NS EA NA WA CSA 2724

HapMap Linkage Disequilibrium report for KCNK17 (39266777 - 39282329 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KCNK17:    About this table     
Variant IDTypeSubtypePubMed ID
nsv830645CNV Loss17160897
nsv830644CNV Loss17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KCNK17
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607370    OMIM disorders: --

6 diseases for KCNK17:    About MalaCards
prosopagnosia    maturity-onset diabetes of the young    cholera    pancreatitis
hepatitis    neuronitis


KCNK17 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNK17
Human Genome Epidemiology (HuGE) Navigator: KCNK17 (1 document)

Export disorders for KCNK17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KCNK17 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with KCNK17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (2012)
  2. Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. (2010)
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  7. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PubMed id 11263999)1, 2 Girard C.... Lesage F. (2001)
  8. Characterization of TASK-4, a novel member of the pH-sensitive, two- pore domain potassium channel family. (PubMed id 11248242)1, 2 Decher N.... Steinmeyer K. (2001)
  9. The rs10947803 SNP of KCNK17 is associated with cerebr al hemorrhage but not ischemic stroke in a Chinese population. (PubMed id 23391755)1 Ma Q....Wang X. (2013)
  10. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89822 HGNC: 14465 AceView: KCNK17 Ensembl:ENSG00000124780 euGenes: HUgn89822
ECgene: KCNK17 H-InvDB: KCNK17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNK17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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