KCNK17 Gene
protein-coding GIFtS: 48
GCID: GC06M039266
|
|
potassium channel, subfamily K, member 17
| |
Aliases
for KCNK17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel, Subfamily K, Member 171 2 | | Acid-Sensitive Potassium Channel Protein TASK-42 3 | | TALK21 2 3 5 | | 2P Domain Potassium Channel Talk-22 3 | | TASK41 2 3 5 | | TWIK-Related Acid-Sensitive K(+) Channel 42 3 | | TALK-21 2 3 | | TWIK-Related Alkaline PH-Activated K(+) Channel 22 3 | | K2p17.11 2 | | Potassium Channel Subfamily K Member 172 | | TASK-41 2 | | |
Export aliases for KCNK17 gene to outside databasesPrevious GC identifers: GC06M039268 GC06M039313 GC06M039374 GC06M038985 |
Summaries
for KCNK17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNK17:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming Pdomains. This channel is an open rectifier which primarily passes outward current under physiological K+concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents
Gene Wiki entry for KCNK17
|
Genomic Views
for KCNK17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNK17 gene promoter:
RFX1 Nkx6-1 Pbx1a Pax-2 Pax-2a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNK17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21KCNK17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M039266: view genomic region
(about GC identifiers)
Start:
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39,266,777 bp from pter |
End:
|
39,282,329 bp from pter |
Size:
|
15,553 bases |
Orientation:
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minus strand |
|
Proteins
for KCNK17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54 (See
protein sequence)Recommended Name: Potassium channel subfamily K member 17 Size: 332 amino acids; 36895 Da
Subunit: Homodimer (Potential)
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinineand isoflurane
Sequence caution: Sequence=AAK28551.1; Type=Frameshift; Positions=260;
Secondary accessions: Q5TCF4 Q8TAW4 Q9BXD1 Q9H592Explore the universe of human proteins at neXtProt for KCNK17: NX_Q96T54
KCNK17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001128583.1 NP_113648.2
ENSEMBL proteins: ENSP00000362328 ENSP00000401271 Reactome Protein details: Q96T54
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KCNK17 for ontologies About GeneDecksing
KCNK17 Antibody Products:
Assay Products for KCNK17: |
Protein
Domains /
Families
for KCNK17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNK17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T54ProtoNet protein and cluster: Q96T54 3 Blocks protein families: IPB003092 TASK K+ channel signature IPB003280 Two pore domain K+ channel signature IPB013099 Ion transport 2
UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family |
Function
for KCNK17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCNKH_HUMAN, Q96T54Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK17 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KCNK17 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KCNK17:
|
Pathways & Interactions
for KCNK17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | | | 5 | Potassium Channels | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK17 (see all 13)
4 
Reactome Pathways for KCNK17
KCNK17 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK17
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
KCNK17 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNK17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for KCNK17 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| YS-035 hydrochloride | Inhibits K+ outward/pacemaker current | [33978-72-2] | | DMP 543 | K+ channel blocker and potent ACh release enhancer | [160588-45-4] |
Search CenterWatch for drugs/clinical trials and news about KCNK17 / KCNKH
|
Transcripts
for KCNK17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNK17 gene (2 alternative transcripts): NM_001135111.1 NM_031460.3 Unigene Cluster for KCNK17: Potassium channel, subfamily K, member 17 Hs.162282 [show with all ESTs]Unigene Representative Sequence: NM_0011351113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373231(uc003ooo.3) ENST00000453413(uc003oop.3) ENST00000503878
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK17 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KCNK17 (NM_031460) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNK17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK17 |
Additional cDNA sequence: AF339912.1 AF358910.1 AK310582.1 AK315273.1 AY358853.1 BC025726.1 EU978944.1 3 DOTS entries: DT.100672954 DT.100775527 DT.95360336 24/28 AceView cDNA sequences (see all 28): BQ267373 BQ272607 CR613884 AY358853 BC025726 AF358910 CR622971 CR626629 BF352053 AA553991 BX346190 AF339912 AI740592 BX355808 BX398164 BI838440 BX346189 NM_031460 BX355809 CA425995 BI524751 BU950193 BX104341 BI524180
GeneLoc Exon Structure
|
Expression
for KCNK17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNK17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCNK17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNK17
SOURCE GeneReport for Unigene cluster: Hs.162282
SABiosciences Custom PCR Arrays for KCNK17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK17
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK17 |
Orthologs
for KCNK17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNK17 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNK171 |
potassium channel, subfamily K, member 17 |
63.09(n)
60.37(a) |
|
421423 XM_419477.2 XP_419477.2 |
lizard
(Anolis carolinensis) |
Reptilia |
KCNK176KCNK126 |
-- |
58(a)20(a) |
1 ↔ 1possible ortholog |
1(246640672-246674042) 1(254990917-254991252) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR769785.16 |
-- |
18(a) |
possible ortholog |
13(49262139-49262480) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ork16 |
Open rectifier K[+] channel 1 |
6(a) |
possible ortholog |
X(10772087-10784957) |
ENSEMBL Gene Tree for KCNK17 (if available)
TreeFam Gene Tree for KCNK17 (if available) |
Paralogs
for KCNK17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNK17 gene
- KCNK152 KCNK52 KCNK162 KCNK32 KCNK122 KCNK92 KCNK62 KCNK22
- KCNK182 KCNK102 KCNK72 KCNK42 KCNK132 KCNK12
4 SIMAP similar genes for KCNK17 using alignment to 3 protein entries: KCNKH_HUMAN (see all proteins):KCNK16 KCNK2 KCNK6 KCNK4
KCNK17 for paralogs About GeneDecksing
|
Genomic Variants
for KCNK17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNK17 (39266777 - 39282329 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNK17: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK17 |
|
Disorders
/ Diseases
for KCNK17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNK17 for disorders About GeneDecksing
OMIM gene information: 607370
OMIM disorders: --
2  diseases for KCNK17: About MalaCardsprosopagnosia pancreatitis
Human Genome Epidemiology (HuGE) Navigator: KCNK17 (1 document)
Export disorders for KCNK17 gene to outside databases
|
Publications
for KCNK17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNK17 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KCNK17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PubMed id 11263999)1, 2 Girard C.... Lesage F. (2001)
- Characterization of TASK-4, a novel member of the pH-sensitive, two- pore domain potassium channel family. (PubMed id 11248242)1, 2 Decher N.... Steinmeyer K. (2001)
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1 Ding H....Wang D.W. (2010)
- KCNK17 genetic variants in ischemic stroke. (PubMed id 19647252)1 Domingues-Montanari S....Montaner J. (2010)
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1 Gierten J....Thomas D. (2008)
|
External Searches for KCNK17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNK17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNK17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNK17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNK17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNK17 gene:
Search GeneIP for patents involving KCNK17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNK17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK17 |
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