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Aliases for KCNK17 Gene

Aliases for KCNK17 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 17 2 3
  • TALK2 3 4 6
  • TASK4 3 4 6
  • TWIK-Related Alkaline PH-Activated K(+) Channel 2 3 4
  • Acid-Sensitive Potassium Channel Protein TASK-4 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 4 3 4
  • 2P Domain Potassium Channel Talk-2 3 4
  • TALK-2 3 4
  • Potassium Channel, Subfamily K, Member 17 2
  • Potassium Channel Subfamily K Member 17 3
  • K2p17.1 3
  • TASK-4 3

External Ids for KCNK17 Gene

Previous GeneCards Identifiers for KCNK17 Gene

  • GC06M039268
  • GC06M039313
  • GC06M039374
  • GC06M039266
  • GC06M038985

Summaries for KCNK17 Gene

Entrez Gene Summary for KCNK17 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK17 Gene

KCNK17 (Potassium Channel, Two Pore Domain Subfamily K, Member 17) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK17 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents

Tocris Summary for KCNK17 Gene

Gene Wiki entry for KCNK17 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK17 Gene

Genomics for KCNK17 Gene

Regulatory Elements for KCNK17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK17 Gene

Start:
39,299,001 bp from pter
End:
39,314,553 bp from pter
Size:
15,553 bases
Orientation:
Minus strand

Genomic View for KCNK17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK17 Gene

Proteins for KCNK17 Gene

  • Protein details for KCNK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T54-KCNKH_HUMAN
    Recommended name:
    Potassium channel subfamily K member 17
    Protein Accession:
    Q96T54
    Secondary Accessions:
    • E9PB46
    • Q5TCF4
    • Q8TAW4
    • Q9BXD1
    • Q9H592

    Protein attributes for KCNK17 Gene

    Size:
    332 amino acids
    Molecular mass:
    36895 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane
    SequenceCaution:
    • Sequence=AAK28551.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK17 Gene

Proteomics data for KCNK17 Gene at MOPED

Post-translational modifications for KCNK17 Gene

Other Protein References for KCNK17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK17 Gene

Domains for KCNK17 Gene

Gene Families for KCNK17 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q96T54

UniProtKB/Swiss-Prot:

KCNKH_HUMAN :
  • Q96T54
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK17: view

Function for KCNK17 Gene

Molecular function for KCNK17 Gene

UniProtKB/Swiss-Prot Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents

Gene Ontology (GO) - Molecular Function for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA 11248242
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK17: view

Phenotypes for KCNK17 Gene

GenomeRNAi human phenotypes for KCNK17:
genes like me logo Genes that share phenotypes with KCNK17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK17 Gene

Localization for KCNK17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK17 Gene COMPARTMENTS Subcellular localization image for KCNK17 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK17: view

Pathways for KCNK17 Gene

genes like me logo Genes that share pathways with KCNK17: view

Interacting Proteins for KCNK17 Gene

Gene Ontology (GO) - Biological Process for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IDA 11248242
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK17: view

Compounds for KCNK17 Gene

(5) Tocris Compounds for KCNK17 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]
genes like me logo Genes that share compounds with KCNK17: view

Transcripts for KCNK17 Gene

Unigene Clusters for KCNK17 Gene

Potassium channel, subfamily K, member 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCNK17
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK17 Gene

No ASD Table

Relevant External Links for KCNK17 Gene

GeneLoc Exon Structure for
KCNK17
ECgene alternative splicing isoforms for
KCNK17

Expression for KCNK17 Gene

mRNA expression in normal human tissues for KCNK17 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK17 Gene

This gene is overexpressed in Artery - Aorta (17.7), Artery - Coronary (7.5), and Lung (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK17 Gene

SOURCE GeneReport for Unigene cluster for KCNK17 Gene Hs.162282

genes like me logo Genes that share expressions with KCNK17: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNK17 Gene

Orthologs for KCNK17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK17 35
  • 98.9 (n)
  • 97.89 (a)
KCNK17 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK17 35
  • 83.28 (n)
  • 76.16 (a)
KCNK17 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK17 35
  • 87.92 (n)
  • 84.78 (a)
KCNK17 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KCNK17 35
  • 60.95 (n)
  • 58.03 (a)
KCNK17 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK17 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk17 35
  • 62.14 (n)
  • 51.76 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNK17 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.6929 36
  • 28 (a)
ManyToMany
Species with no ortholog for KCNK17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK17 Gene

ENSEMBL:
Gene Tree for KCNK17 (if available)
TreeFam:
Gene Tree for KCNK17 (if available)

Paralogs for KCNK17 Gene

Selected SIMAP similar genes for KCNK17 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNK17: view

Variants for KCNK17 Gene

Sequence variations from dbSNP and Humsavar for KCNK17 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1078911 -- 39,303,763(-) CAACG(C/T)GGAGA intron-variant
rs1078912 -- 39,303,734(-) GCCCA(C/T)CTATT intron-variant
rs1535496 -- 39,299,977(+) TATGC(A/T)CCATC intron-variant, downstream-variant-500B
rs1535497 -- 39,299,978(+) ATGCT(C/T)CATCC intron-variant, downstream-variant-500B
rs1544048 -- 39,311,103(+) acaca(C/T)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK17 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897
nsv830645 CNV Loss 17160897

Relevant External Links for KCNK17 Gene

HapMap Linkage Disequilibrium report
KCNK17
Human Gene Mutation Database (HGMD)
KCNK17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK17 Gene

Disorders for KCNK17 Gene

Relevant External Links for KCNK17

Genetic Association Database (GAD)
KCNK17
Human Genome Epidemiology (HuGE) Navigator
KCNK17
genes like me logo Genes that share disorders with KCNK17: view

No data available for UniProtKB/Swiss-Prot for KCNK17 Gene

Publications for KCNK17 Gene

  1. Characterization of TASK-4, a novel member of the pH-sensitive, two- pore domain potassium channel family. (PMID: 11248242) Decher N. … Steinmeyer K. (FEBS Lett. 2001) 3 4
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C. … Lesage F. (Biochem. Biophys. Res. Commun. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KCNK17 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KCNK17
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK17
  • Block miRNA regulation of KCNK17 using miScript Target Protectors

Sources for KCNK17 Gene

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