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KCNK16 Gene

protein-coding   GIFtS: 52
GCID: GC06M039282

Potassium Channel, Subfamily K, Member 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel, Subfamily K, Member 161 2     TWIK-Related Alkaline PH-Activated K(+) Channel 12 3
TALK12 3 5     K2p16.12
2P Domain Potassium Channel Talk-12 3     Pancreatic Potassium Channel Talk-12
TALK-12 3     Potassium Channel Subfamily K Member 162

External Ids:    HGNC: 144641   Entrez Gene: 837952   Ensembl: ENSG000000959817   OMIM: 6073695   UniProtKB: Q96T553   

Export aliases for KCNK16 gene to outside databases

Previous GC identifers: GC06M039284 GC06M039329 GC06M039390 GC06M039000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNK16 Gene:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P
domains. This channel is an open rectifier which primarily passes outward current under physiological K+
concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several
alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
(provided by RefSeq, Sep 2008)

GeneCards Summary for KCNK16 Gene:
KCNK16 (potassium channel, subfamily K, member 16) is a protein-coding gene. Diseases associated with KCNK16 include maturity-onset diabetes of the young, and pancreatitis. GO annotations related to this gene include voltage-gated ion channel activity and potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents

Gene Wiki entry for KCNK16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK16 gene promoter:
         Oct-B1   RFX1   oct-B2   Pbx1a   Pax-2   Pax-2a   Tal-1beta   E47   Nkx6-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK16 promoter sequence
   Search Chromatin IP Primers for KCNK16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2-p21.1   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2-p21.1

KCNK16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M039282:  view genomic region     (about GC identifiers)

Start:
39,282,474 bp from pter      End:
39,290,744 bp from pter
Size:
8,271 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 16  
Size: 309 amino acids; 34153 Da
Subunit: Homodimer (Potential)
Miscellaneous: Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH
Secondary accessions: B5TJL9 Q2M2N9 Q5TCF3 Q6X6Z3 Q6X6Z4 Q6X6Z5 Q9H591
Alternative splicing: 4 isoforms:  Q96T55-1   Q96T55-3   Q96T55-4   Q96T55-5   

Explore the universe of human proteins at neXtProt for KCNK16: NX_Q96T55

REFSEQ proteins (4 alternative transcripts): 
NP_001128577.1  NP_001128578.1  NP_001128579.1  NP_115491.1  

ENSEMBL proteins: 
 ENSP00000362326   ENSP00000391498   ENSP00000423842   ENSP00000362324   ENSP00000415375  
Reactome Protein details: Q96T55

KCNK16 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for KCNK16


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
KCN: Potassium channels
KCNK: Voltage-gated ion channels / Potassium channels, Two-P

IUPHAR Guide to PHARMACOLOGY protein family classification: K2P16.1
Two-P potassium channels

3 InterPro protein domains:
 IPR003280 2pore_dom_K_chnl
 IPR013099 2pore_dom_K_chnl_dom
 IPR003092 2pore_dom_K_chnl_TASK

Graphical View of Domain Structure for InterPro Entry Q96T55

ProtoNet protein and cluster: Q96T55

3 Blocks protein domains:
IPB003092 TASK K+ channel signature
IPB003280 Two pore domain K+ channel signature
IPB013099 Ion transport 2


UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55
Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


KCNK16 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCNKG_HUMAN, Q96T55
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005244voltage-gated ion channel activity IEA--
GO:0005267potassium channel activity IDA11263999
     
KCNK16 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for KCNK16:
 Decreased cell number and incr 

     1 MGI phenotypic allele for Kcnk16 (no phenotypes)

KCNK16 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Kcnk16tm1Lex for KCNK16

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNK16
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNK16
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNK16

miRNA
Products:
    
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1 qRT-PCR Assays for microRNA that regulate KCNK16:
hsa-miR-30b*
SwitchGear 3'UTR luciferase reporter plasmidKCNK16 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for KCNK16
Predesigned siRNA for gene silencing in human, mouse, rat KCNK16

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GenScript: all cDNA clones in your preferred vector (see all 4): KCNK16 (NM_001135107)
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KCNKG_HUMAN, Q96T55: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
endoplasmic reticulum1
extracellular1
lysosome1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

KCNK16 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KCNK16 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Sweet Taste Signaling
Sweet Taste Signaling0.72
Bitter Taste Signaling0.44
Melatonin Signaling0.72
Sperm Motility0.37
Cellular Effects of Sildenafil0.46
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
PKA Signaling0.56
cAMP Pathway0.77
3Neuropathic Pain-Signaling in Dorsal Horn Neurons
Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
Cholera Infection0.40
Aldosterone Signaling in Epithelial Cells0.47
4Potassium Channels
Potassium Channels0.43
TWIK-related alkaline pH activated K+ channel (TALK)0.00
Tandem pore domain potassium channels0.00
5Hepatic ABC Transporters
Hepatic ABC Transporters0.41
MODY (Maturity-Onset Diabetes of Young)0.41

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNK16 (see all 13)
    Cholera Infection
Neuropathic Pain-Signaling in Dorsal Horn Neurons
Hepatic ABC Transporters
PKA Signaling
Sweet Taste Signaling

1 Reactome Pathway for KCNK16
    TWIK-related alkaline pH activated K+ channel (TALK)



KCNK16 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNK16
Interactions:

    Search GeneGlobe Interaction Network for KCNK16

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for KCNK16 (ENSP000003914984) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
SORT1ENSP000002566374STRING: ENSP00000256637
MAPK11ENSP000003336854STRING: ENSP00000333685
MAPK13ENSP000002112874STRING: ENSP00000211287
MAPK14ENSP000002297944STRING: ENSP00000229794
SRPK1ENSP000003910694STRING: ENSP00000391069
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----
GO:0006813potassium ion transport IDA11263999
GO:0007268synaptic transmission TAS--
GO:0055085transmembrane transport ----

KCNK16 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for KCNK16 available from Tocris Bioscience    About this table
CompoundAction CAS #
Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KCNK16 gene (4 alternative transcripts): 
NM_001135105.1  NM_001135106.1  NM_001135107.1  NM_032115.3  

Unigene Cluster for KCNK16:

Potassium channel, subfamily K, member 16
Hs.287765  [show with all ESTs]
Unigene Representative Sequence: NM_001135105
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373229(uc003ooq.3 uc010jwy.3) ENST00000425054(uc003oor.4)
ENST00000507712 ENST00000373227 ENST00000437525(uc011dtz.1)
miRNA
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1 qRT-PCR Assays for microRNA that regulate KCNK16:
hsa-miR-30b*
SwitchGear 3'UTR luciferase reporter plasmidKCNK16 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat KCNK16
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GenScript: all cDNA clones in your preferred vector (see all 4): KCNK16 (NM_001135107)
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  QuantiFast Probe-based Assays in human, mouse, rat KCNK16

Additional mRNA sequence: 

AF358909.1 AY253145.1 AY253146.1 AY253147.1 BC111860.1 EU978943.1 

3 DOTS entries:

DT.101973012  DT.97774207  DT.97794751 

22 AceView cDNA sequences:

BM504060 BQ128142 CK905734 NM_032115 BU789594 BQ925824 BU789531 BQ127873 
AF358909 AY253146 BI710990 BU789868 AY253147 BU787720 AY253145 BI711434 
CK905735 BQ268142 BQ777253 CA843225 BQ787952 BQ952392 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1:        -                             -     -     -                     
SP2:                                            -     -                     
SP3:                                      -     -                           
SP4:                                      -     -     -                     
SP5:                                                                        


ECgene alternative splicing isoforms for KCNK16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNK16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACAAGTGGC
KCNK16 Expression
About this image


KCNK16 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Pancreas (Endocrine System)    fully expand to see all 4 entries
         Endocrine Progenitor Cells Ventral Pancreatic Bud
KCNK16 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.287765

UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55
Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KCNK16 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcnk161 , 5 potassium channel, subfamily K, member 161, 5 86.76(n)1
88.01(a)1
  14 (11.49 cM)5
745711  NM_029006.11  NP_083282.11 
 202627565 
chicken
(Gallus gallus)
Aves KCNK161 potassium channel, subfamily K, member 16 68.96(n)
64.86(a)
  772022  XM_001235223.2  XP_001235224.1 
lizard
(Anolis carolinensis)
Reptilia KCNK166
potassium channel, subfamily K, member 16
56(a)
1 ↔ 1
1(246677431-246691184)
African clawed frog
(Xenopus laevis)
Amphibia 480255682   -- 73.59(n)    48025568 
zebrafish
(Danio rerio)
Actinopterygii LOC1018821391 potassium channel subfamily K member 17-like 50.28(n)
42.98(a)
  101882139  XM_005158911.1  XP_005158968.1 


ENSEMBL Gene Tree for KCNK16 (if available)
TreeFam Gene Tree for KCNK16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KCNK16 gene
KCNK152  KCNK52  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  KCNK102  
KCNK72  KCNK172  KCNK42  KCNK132  KCNK12  
8 SIMAP similar genes for KCNK16 using alignment to 2 protein entries:     KCNKG_HUMAN (see all proteins):
KCNK2    KCNK17    KCNK10    KCNK4    KCNK1    KCNK9
KCNK6    KCNK15

KCNK16 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for KCNK16
PGOHUM00000250175


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCNK16 (see all 255)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs92962931,2
C,F--39284283(+) TCCATA/CGGGAC 4 -- int11Minor allele frequency- C:0.07WA 118
rs94625261,2
F,A--39284341(+) GCAGTT/GGAGGT 4 -- int11Minor allele frequency- G:0.07WA 118
rs94710671,2
C,F,A--39284357(+) TCTGCA/GGGGTG 4 -- int11Minor allele frequency- G:0.07WA 118
rs1132137791,2
C,F--39284378(+) CTAGAC/TCAGAA 4 -- int11Minor allele frequency- T:0.03NA 120
rs1896842221,2
--39284438(+) TTTGGC/TTCCCT 4 -- int10--------
rs1809023941,2
C--39284554(+) TGTTCC/TCACCA 4 -- int10--------
rs94625271,2,,4
C,F,A--39284574(+) TCCCCA/GAAGCC 8 F syn14Minor allele frequency- G:0.02NS WA NA EU 6055
rs412731321,2
C,F--39284597(+) AGTGAT/GGAAAG 8 /I /L mis13Minor allele frequency- G:0.00NA EU 5857
rs1382475621,2
C--39284609(+) AAAGTA/GGAAGC 8 H Y mis10--------
rs2018927641,2
--39284679(+) ACCAGC/TGTCCC 8 T syn10--------

HapMap Linkage Disequilibrium report for KCNK16 (39282474 - 39290744 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KCNK16:    About this table    
Variant IDTypeSubtypePubMed ID
nsv830645CNV Loss17160897
nsv830644CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KCNK16
DNA2.0 Custom Variant and Variant Library Synthesis for KCNK16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607369    OMIM disorders: --

5 diseases for KCNK16:    
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maturity-onset diabetes of the young    pancreatitis    cholera    neuronitis
hepatitis


KCNK16 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNK16

Export disorders for KCNK16 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCNK16 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KCNK16)
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  1. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PubMed id 11263999)1, 2, 3 Girard C.... Lesage F. (Biochem. Biophys. Res. Commun. 2001)
  2. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PubMed id 12724142)1, 2, 9 Han J.... Kim D. (Am. J. Physiol. 2003)
  3. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (Nat. Genet. 2012)
  4. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1, 2 Gierten J....Thomas D. (Br. J. Pharmacol. 2008)
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
  6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Potassium leak channels and the KCNK family of two-P-domain subunits. (PubMed id 11256078)1 Goldstein S.A....Zilberberg N. (Nat. Rev. Neurosci. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83795 HGNC: 14464 AceView: KCNK16 Ensembl:ENSG00000095981 euGenes: HUgn83795
ECgene: KCNK16 H-InvDB: KCNK16

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNK16 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNK16 gene:
Search GeneIP for patents involving KCNK16

GeneCards and IP:
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