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Aliases for KCNK16 Gene

Aliases for KCNK16 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 16 2 3
  • TALK1 3 4 6
  • TWIK-Related Alkaline PH-Activated K(+) Channel 1 3 4
  • Potassium Channel, Subfamily K, Member 16 2 3
  • 2P Domain Potassium Channel Talk-1 3 4
  • TALK-1 3 4
  • Potassium Channel Subfamily K Member 16 3
  • Pancreatic Potassium Channel Talk-1 3
  • K2p16.1 3

External Ids for KCNK16 Gene

Summaries for KCNK16 Gene

Entrez Gene Summary for KCNK16 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK16 Gene

KCNK16 (Potassium Channel, Two Pore Domain Subfamily K, Member 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK16 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents

Gene Wiki entry for KCNK16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK16 Gene

Genomics for KCNK16 Gene

Genomic Location for KCNK16 Gene

39,314,698 bp from pter
39,322,968 bp from pter
8,271 bases
Minus strand

Genomic View for KCNK16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK16 Gene

Regulatory Elements for KCNK16 Gene

Proteins for KCNK16 Gene

  • Protein details for KCNK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 16
    Protein Accession:
    Secondary Accessions:
    • B5TJL9
    • Q2M2N9
    • Q5TCF3
    • Q6X6Z3
    • Q6X6Z4
    • Q6X6Z5
    • Q9H591

    Protein attributes for KCNK16 Gene

    309 amino acids
    Molecular mass:
    34153 Da
    Quaternary structure:
    • Homodimer.
    • Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH

    Alternative splice isoforms for KCNK16 Gene


neXtProt entry for KCNK16 Gene

Proteomics data for KCNK16 Gene at MOPED

Post-translational modifications for KCNK16 Gene

No Post-translational modifications

Other Protein References for KCNK16 Gene

No data available for DME Specific Peptides for KCNK16 Gene

Domains for KCNK16 Gene

Gene Families for KCNK16 Gene

  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P


  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.:
    • Q96T55
genes like me logo Genes that share domains with KCNK16: view

Function for KCNK16 Gene

Molecular function for KCNK16 Gene

UniProtKB/Swiss-Prot Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents

Gene Ontology (GO) - Molecular Function for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA 11263999
GO:0005515 protein binding IPI 25416956
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK16: view

Phenotypes for KCNK16 Gene

GenomeRNAi human phenotypes for KCNK16:
genes like me logo Genes that share phenotypes with KCNK16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK16 Gene

Localization for KCNK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK16 Gene COMPARTMENTS Subcellular localization image for KCNK16 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK16: view

Pathways for KCNK16 Gene

genes like me logo Genes that share pathways with KCNK16: view

Gene Ontology (GO) - Biological Process for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport IDA 11263999
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK16: view

Compounds for KCNK16 Gene

(5) Tocris Compounds for KCNK16 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
Tetraethylammonium chloride Non-selective K+ channel blocker [56-34-8]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [33978-72-2]
genes like me logo Genes that share compounds with KCNK16: view

Transcripts for KCNK16 Gene

Unigene Clusters for KCNK16 Gene

Potassium channel, subfamily K, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for KCNK16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK16 Gene

mRNA expression in normal human tissues for KCNK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK16 Gene

This gene is overexpressed in Pancreas (44.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK16 Gene

SOURCE GeneReport for Unigene cluster for KCNK16 Gene Hs.287765

mRNA Expression by UniProt/SwissProt for KCNK16 Gene

Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested.
genes like me logo Genes that share expressions with KCNK16: view

Orthologs for KCNK16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNK16 37
  • 76 (a)
(Bos Taurus)
Mammalia KCNK16 36
  • 89.8 (n)
  • 88.44 (a)
KCNK16 37
  • 59 (a)
(Canis familiaris)
Mammalia KCNK16 36
  • 89.57 (n)
  • 90.14 (a)
(Mus musculus)
Mammalia Kcnk16 36
  • 86.76 (n)
  • 88.01 (a)
Kcnk16 16
Kcnk16 37
  • 73 (a)
(Monodelphis domestica)
Mammalia KCNK16 37
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK16 37
  • 60 (a)
(Rattus norvegicus)
Mammalia Kcnk16 36
  • 86.99 (n)
  • 88.01 (a)
(Gallus gallus)
Aves KCNK16 36
  • 68.96 (n)
  • 64.86 (a)
KCNK16 37
  • 50 (a)
(Anolis carolinensis)
Reptilia KCNK16 37
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk16 36
  • 68.61 (n)
  • 63.27 (a)
(Danio rerio)
Actinopterygii LOC101882139 36
  • 50.28 (n)
  • 42.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
CSA.6929 37
  • 27 (a)
Species with no ortholog for KCNK16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK16 Gene

Gene Tree for KCNK16 (if available)
Gene Tree for KCNK16 (if available)

Paralogs for KCNK16 Gene

Selected SIMAP similar genes for KCNK16 Gene using alignment to 2 proteins: Pseudogenes for KCNK16 Gene

genes like me logo Genes that share paralogs with KCNK16: view

Variants for KCNK16 Gene

Sequence variations from dbSNP and Humsavar for KCNK16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs734659 -- 39,318,314(-) CAGCC(C/T)GCAAG intron-variant
rs1109772 -- 39,321,169(+) ggtgc(A/G)gagtg intron-variant
rs1109773 -- 39,321,388(+) CCTCA(C/G)TTCCC intron-variant
rs1109798 -- 39,322,099(-) CCAAA(C/T)AGCCT intron-variant
rs1328384 -- 39,324,031(-) CAGAG(G/T)GGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNK16 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897
nsv830645 CNV Loss 17160897

Relevant External Links for KCNK16 Gene

HapMap Linkage Disequilibrium report

Disorders for KCNK16 Gene

Relevant External Links for KCNK16

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with KCNK16: view

No data available for UniProtKB/Swiss-Prot for KCNK16 Gene

Publications for KCNK16 Gene

  1. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PMID: 12724142) Han J. … Kim D. (Am. J. Physiol. 2003) 3 4 23
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C. … Lesage F. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  5. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J. … Thomas D. (Br. J. Pharmacol. 2008) 3 4

Products for KCNK16 Gene

Sources for KCNK16 Gene

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