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Aliases for KCNK16 Gene

Aliases for KCNK16 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 16 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 16 2 3 5
  • TWIK-Related Alkaline PH-Activated K(+) Channel 1 3 4
  • Potassium Channel, Subfamily K, Member 16 2 3
  • 2P Domain Potassium Channel Talk-1 3 4
  • TALK-1 3 4
  • TALK1 3 4
  • Pancreatic Potassium Channel Talk-1 3
  • K2p16.1 3

External Ids for KCNK16 Gene

Previous GeneCards Identifiers for KCNK16 Gene

  • GC06M039284
  • GC06M039329
  • GC06M039390
  • GC06M039282
  • GC06M039000
  • GC06M039317
  • GC06M039353

Summaries for KCNK16 Gene

Entrez Gene Summary for KCNK16 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK16 Gene

KCNK16 (Potassium Two Pore Domain Channel Subfamily K Member 16) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Hepatic ABC Transporters. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK16 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Tocris Summary for KCNK16 Gene

Gene Wiki entry for KCNK16 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK16 Gene

Genomics for KCNK16 Gene

Regulatory Elements for KCNK16 Gene

Genomic Location for KCNK16 Gene

Chromosome:
6
Start:
39,314,698 bp from pter
End:
39,322,985 bp from pter
Size:
8,288 bases
Orientation:
Minus strand

Genomic View for KCNK16 Gene

Genes around KCNK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK16 Gene

Proteins for KCNK16 Gene

  • Protein details for KCNK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T55-KCNKG_HUMAN
    Recommended name:
    Potassium channel subfamily K member 16
    Protein Accession:
    Q96T55
    Secondary Accessions:
    • B5TJL9
    • Q2M2N9
    • Q5TCF3
    • Q6X6Z3
    • Q6X6Z4
    • Q6X6Z5
    • Q9H591

    Protein attributes for KCNK16 Gene

    Size:
    309 amino acids
    Molecular mass:
    34153 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.

    Alternative splice isoforms for KCNK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK16 Gene

Proteomics data for KCNK16 Gene at MOPED

Post-translational modifications for KCNK16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNK16 Gene

No data available for DME Specific Peptides for KCNK16 Gene

Domains & Families for KCNK16 Gene

Gene Families for KCNK16 Gene

Suggested Antigen Peptide Sequences for KCNK16 Gene

Graphical View of Domain Structure for InterPro Entry

Q96T55

UniProtKB/Swiss-Prot:

KCNKG_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK16: view

Function for KCNK16 Gene

Molecular function for KCNK16 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Gene Ontology (GO) - Molecular Function for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IDA,TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCNK16: view

Phenotypes for KCNK16 Gene

GenomeRNAi human phenotypes for KCNK16:
genes like me logo Genes that share phenotypes with KCNK16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK16

miRNA for KCNK16 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK16 Gene

Localization for KCNK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK16 Gene COMPARTMENTS Subcellular localization image for KCNK16 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for KCNK16 Gene

Pathways & Interactions for KCNK16 Gene

genes like me logo Genes that share pathways with KCNK16: view

Gene Ontology (GO) - Biological Process for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IDA 11263999
genes like me logo Genes that share ontologies with KCNK16: view

No data available for SIGNOR curated interactions for KCNK16 Gene

Drugs & Compounds for KCNK16 Gene

(5) Additional Compounds for KCNK16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
PK-THPP
1332454-07-5

(5) Tocris Compounds for KCNK16 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
genes like me logo Genes that share compounds with KCNK16: view

Transcripts for KCNK16 Gene

Unigene Clusters for KCNK16 Gene

Potassium channel, subfamily K, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for KCNK16 Gene

GeneLoc Exon Structure for
KCNK16
ECgene alternative splicing isoforms for
KCNK16

Expression for KCNK16 Gene

mRNA expression in normal human tissues for KCNK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK16 Gene

This gene is overexpressed in Pancreas (x44.6).

Protein differential expression in normal tissues from HIPED for KCNK16 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK16 Gene



SOURCE GeneReport for Unigene cluster for KCNK16 Gene Hs.287765

mRNA Expression by UniProt/SwissProt for KCNK16 Gene

Q96T55-KCNKG_HUMAN
Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested.
genes like me logo Genes that share expression patterns with KCNK16: view

Protein tissue co-expression partners for KCNK16 Gene

Primer Products

In Situ Assay Products

Orthologs for KCNK16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK16 35
  • 89.8 (n)
  • 88.44 (a)
KCNK16 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK16 35
  • 89.57 (n)
  • 90.14 (a)
mouse
(Mus musculus)
Mammalia Kcnk16 35
  • 86.76 (n)
  • 88.01 (a)
Kcnk16 16
Kcnk16 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk16 35
  • 86.99 (n)
  • 88.01 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK16 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK16 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK16 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK16 35
  • 68.96 (n)
  • 64.86 (a)
KCNK16 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK16 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk16 35
  • 68.61 (n)
  • 63.27 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882139 35
  • 50.28 (n)
  • 42.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
CSA.6929 36
  • 27 (a)
ManyToMany
Species with no ortholog for KCNK16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK16 Gene

ENSEMBL:
Gene Tree for KCNK16 (if available)
TreeFam:
Gene Tree for KCNK16 (if available)

Paralogs for KCNK16 Gene

(8) SIMAP similar genes for KCNK16 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KCNK16 Gene

genes like me logo Genes that share paralogs with KCNK16: view

Variants for KCNK16 Gene

Sequence variations from dbSNP and Humsavar for KCNK16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_052430 -
VAR_063636 -
VAR_063637 -

Structural Variations from Database of Genomic Variants (DGV) for KCNK16 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV Loss 17160897
nsv830645 CNV Loss 17160897

Variation tolerance for KCNK16 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK16 Gene

HapMap Linkage Disequilibrium report
KCNK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK16 Gene

Disorders for KCNK16 Gene

Relevant External Links for KCNK16

Genetic Association Database (GAD)
KCNK16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK16

No disorders were found for KCNK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK16 Gene

Publications for KCNK16 Gene

  1. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C. … Lesage F. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 67
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  3. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PMID: 12724142) Han J. … Kim D. (Am. J. Physiol. 2003) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3

Products for KCNK16 Gene

Sources for KCNK16 Gene

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