KCNK16 Gene
protein-coding GIFtS: 50
GCID: GC06M039282
|
|
potassium channel, subfamily K, member 16
| |
Aliases for KCNK16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Potassium Channel, Subfamily K, Member 161 2 | | 2P Domain Potassium Channel Talk-12 3 | | TALK11 2 3 5 | | TWIK-Related Alkaline PH-Activated K(+) Channel 12 3 | | TALK-11 2 3 | | Pancreatic Potassium Channel Talk-12 | | K2p16.11 2 | | Potassium Channel Subfamily K Member 162 |
Export aliases for KCNK16 gene to outside databasesPrevious GC identifers: GC06M039284 GC06M039329 GC06M039390 GC06M039000 |
Summaries for KCNK16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for KCNK16: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming Pdomains. This channel is an open rectifier which primarily passes outward current under physiological K+concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Severalalternatively spliced transcript variants encoding different isoforms have been identified for this gene. (provided byRefSeq, Sep 2008) UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents Gene Wiki entry for KCNK16
|
Genomic Views for KCNK16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KCNK16 gene promoter: Oct-B1 RFX1 oct-B2 Pbx1a Pax-2 Pax-2a Tal-1beta E47 Nkx6-1 SEF-1 (1) Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNK16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK16 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.2-p21.1 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.2-p21.1KCNK16 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M039282: view genomic region
(about GC identifiers)
Start:
|
39,282,474 bp from pter |
End:
|
39,290,744 bp from pter |
Size:
|
8,271 bases |
Orientation:
|
minus strand |
|
Proteins for KCNK16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55 (See
protein sequence)Recommended Name: Potassium channel subfamily K member 16 Size: 309 amino acids; 34153 Da
Subunit: Homodimer (Potential)
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH
Secondary accessions: B5TJL9 Q2M2N9 Q5TCF3 Q6X6Z3 Q6X6Z4 Q6X6Z5 Q9H591Alternative splicing: 4 isoforms: Q96T55-1 Q96T55-3 Q96T55-4 Q96T55-5 Explore the universe of human proteins at neXtProt for KCNK16: NX_Q96T55
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96T55 KCNK16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001128577.1 NP_001128578.1 NP_001128579.1 NP_115491.1 ENSEMBL proteins: ENSP00000362326 ENSP00000391498 ENSP00000423842 ENSP00000362324 ENSP00000415375 Reactome Protein details: Q96T55 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
KCNK16 for ontologies About GeneDecksing
KCNK16 Antibody Products: Assay Products for KCNK16: |
Protein
Domains / Families for KCNK16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNK16 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T55ProtoNet protein and cluster: Q96T55 3 Blocks protein families: IPB003092 TASK K+ channel signature IPB003280 Two pore domain K+ channel signature IPB013099 Ion transport 2
UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family |
Function for KCNK16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK16 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK16 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK16 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
KCNK16 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KCNK16: Animal Models: Mouse knock-out Kcnk16tm1Lex for KCNK16 1 MGI phenotypic allele for Kcnk16 (no phenotypes)
KCNK16 for phenotypes About GeneDecksing
|
Pathways & Interactions for KCNK16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Hepatic ABC Transporters | | | 5 | Potassium Channels | |
Pathway sources See GeneCards unified pathways Show all pathways
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK16 (see all 13) 4
Reactome Pathways for KCNK16
KCNK16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK16
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
KCNK16 for ontologies About GeneDecksing
|
Drugs & Compounds for KCNK16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for KCNK16 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| YS-035 hydrochloride | Inhibits K+ outward/pacemaker current | [33978-72-2] | | DMP 543 | K+ channel blocker and potent ACh release enhancer | [160588-45-4] | Search CenterWatch for drugs/clinical trials and news about KCNK16 / KCNKG 
|
Transcripts for KCNK16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for KCNK16 gene (4 alternative transcripts): NM_001135105.1 NM_001135106.1 NM_001135107.1 NM_032115.3 Unigene Cluster for KCNK16: Potassium channel, subfamily K, member 16 Hs.287765 [show with all ESTs]Unigene Representative Sequence: NM_0011351055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373229(uc003ooq.3 uc010jwy.3) ENST00000425054(uc003oor.4) ENST00000507712 ENST00000373227 ENST00000437525(uc011dtz.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK16 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK16 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): KCNK16 (NM_001135107) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNK16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK16  |
Additional cDNA sequence: AF358909.1 AY253145.1 AY253146.1 AY253147.1 BC111860.1 EU978943.1 3 DOTS entries: DT.101973012 DT.97774207 DT.97794751 22 AceView cDNA sequences: NM_032115 BU789531 BQ925824 CK905734 BU789594 BQ128142 BM504060 AY253145 AF358909 BU787720 BQ127873 AY253147 BU789868 AY253146 BI710990 CK905735 BI711434 BQ268142 CA843225 BQ777253 BQ787952 BQ952392 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | |
| SP1: | |   | - |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for KCNK16
|
Expression for KCNK16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNK16 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GACAAGTGGC
About this image See KCNK16 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KCNK16
SOURCE GeneReport for Unigene cluster: Hs.287765 UniProtKB/Swiss-Prot: KCNKG_HUMAN, Q96T55Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested SABiosciences Custom PCR Arrays for KCNK16
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK16 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK16 |
Orthologs for KCNK16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNK16 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
KCNK161 |
potassium channel, subfamily K, member 16 |
68.96(n) 64.86(a) |
  |
772022 XM_001235223.1 XP_001235224.1 |
lizard (Anolis carolinensis) |
Reptilia |
KCNK166KCNK126 |
-- |
55(a)25(a) |
1 ↔ 1possible ortholog |
1(246677431-246691120) 1(254990917-254991252) |
African clawed frog (Xenopus laevis) |
Amphibia |
480255682 |
-- |
73.59(n) |
  |
48025568 |
zebrafish (Danio rerio) |
Actinopterygii |
CR769785.16 |
-- |
27(a) |
possible ortholog |
13(49262139-49262480) |
fruit fly (Drosophila melanogaster) |
Insecta |
Ork16 |
Open rectifier K[+] channel 1 |
6(a) |
possible ortholog |
X(10772087-10784957) |
ENSEMBL Gene Tree for KCNK16 (if available) TreeFam Gene Tree for KCNK16 (if available)  |
Paralogs for KCNK16 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for KCNK16 gene
- KCNK152 KCNK52 KCNK32 KCNK122 KCNK92 KCNK62 KCNK22 KCNK182
- KCNK172 KCNK102 KCNK72 KCNK42 KCNK132 KCNK12
8 SIMAP similar genes for KCNK16 using alignment to 2 protein entries: KCNKG_HUMAN (see all proteins):KCNK2 KCNK17 KCNK10 KCNK4 KCNK1 KCNK9 KCNK6 KCNK15
KCNK16 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KCNK16 PGOHUM00000250175
|
Genomic Variants for KCNK16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNK16 (39282474 - 39290744 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KCNK16: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK16 |
|
Disorders
/ Diseases for KCNK16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNK16 for disorders About GeneDecksing
OMIM gene information: 607369
OMIM disorders: --
1 disease for KCNK16: About MalaCardspancreatitis Export disorders for KCNK16 gene to outside databases
|
Publications for KCNK16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNK16 gene integrated from 9 sources: (articles sorted by number of sources associating them with KCNK16) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PubMed id 11263999)1, 2, 3 Girard C.... Lesage F. (2001)
- Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PubMed id 12724142)1, 2, 9 Han J.... Kim D. (2003)
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1, 2 Gierten J....Thomas D. (2008)
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Potassium leak channels and the KCNK family of two-P-domain subunits. (PubMed id 11256078)1 Goldstein S.A....Zilberberg N. (2001)
|
External Searches for KCNK16 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNK16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNK16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNK16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for KCNK16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNK16 gene: Search GeneIP for patents involving KCNK16
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for KCNK16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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 | |
 |
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 | | KCNK16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK16 |
|  |  |  | | | Search ThermoFisher Antibodies for KCNK16 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK16 |
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