Aliases for KCNK16 Gene
Aliases for KCNK16 Gene
External Ids for KCNK16 Gene
- HGNC: 14464
- Entrez Gene: 83795
- Ensembl: ENSG00000095981
- OMIM: 607369
- UniProtKB: Q96T55
Previous GeneCards Identifiers for KCNK16 Gene
- GC06M039284
- GC06M039329
- GC06M039390
- GC06M039282
- GC06M039000
- GC06M039317
- GC06M039353
- GC06M039393
- GC06M039432
- GC06M039446
Summaries for KCNK16 Gene
-
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for KCNK16 Gene
KCNK16 (Potassium Two Pore Domain Channel Subfamily K Member 16) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK17.
UniProtKB/Swiss-Prot for KCNK16 Gene
-
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK16 Gene
Genomics for KCNK16 Gene
Regulatory Elements for KCNK16 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G039320 | 0.8 | FANTOM5 dbSUPER | 61.5 | +2.7 | 2653 | 0.4 | GATA3 RNF2 CUX1 NR2F2 | KCNK16 KCNK17 GLP1R SAYSD1 |
| GH06G039312 | 0.9 | FANTOM5 dbSUPER | 41.6 | +9.9 | 9874 | 0.4 | SUZ12 GFI1B KLF17 OSR2 FOSL1 JUND ATF3 HNF4A FOS FOSL2 | KCNK16 KCNK17 GLP1R SAYSD1 GC06M039510 LOC105375047 |
| GH06G039361 | 1.3 | Ensembl ENCODE dbSUPER | 11.1 | -39.4 | -39438 | 1.1 | CTCF TFAP4 MXI1 ESRRA TEAD4 MAX ZNF48 RAD21 CTBP1 ZNF143 | KCNK17 KCNK16 LOC100124373 GC06M039512 |
| GH06G039358 | 0.8 | Ensembl dbSUPER | 11.1 | -35.3 | -35316 | 0.2 | OSR2 NFIC NFIA BHLHE40 EGR2 | KCNK17 KCNK16 LOC100124373 GC06M039512 |
| GH06G039067 | 0.7 | dbSUPER | 10.2 | +254.8 | 254762 | 1.9 | HDAC1 ZNF175 CEBPG ZIC2 ZNF335 ZNF766 ZFHX2 EGR1 ELK1 ZNF547 | SAYSD1 KCNK17 KCNK16 KCNK5 GLP1R LOC105375046 |
Regulatory Element Products
Genomic Location for KCNK16 Gene
- Chromosome:
- 6
- Start:
- 39,314,698 bp from pter
- End:
- 39,322,985 bp from pter
- Size:
- 8,288 bases
- Orientation:
- Minus strand
Genomic View for KCNK16 Gene
- Cytogenetic band:
-
- 6p21.2 by Ensembl
- 6p21.2 by Entrez Gene
- 6p21.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK16 Gene
Proteins for KCNK16 Gene
-
Protein details for KCNK16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96T55-KCNKG_HUMAN
- Recommended name:
- Potassium channel subfamily K member 16
- Protein Accession:
- Q96T55
- B5TJL9
- Q2M2N9
- Q5TCF3
- Q6X6Z3
- Q6X6Z4
- Q6X6Z5
- Q9H591
Protein attributes for KCNK16 Gene
- Size:
- 309 amino acids
- Molecular mass:
- 34153 Da
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.
Protein Expression for KCNK16 Gene
Post-translational modifications for KCNK16 Gene
Other Protein References for KCNK16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Gata5 antibody for KCNK16
Protein Products
-
OriGene Purified Proteins for KCNK16
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- Search GeneTex for Proteins for KCNK16
Assay Products
No data available for DME Specific Peptides for KCNK16 Gene
Domains & Families for KCNK16 Gene
Gene Families for KCNK16 Gene
Protein Domains for KCNK16 Gene
Suggested Antigen Peptide Sequences for KCNK16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96T55UniProtKB/Swiss-Prot:
KCNKG_HUMAN :- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
- Domain:
-
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK16 Gene
Molecular function for KCNK16 Gene
- UniProtKB/Swiss-Prot Function:
- Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for KCNK16 Gene
- GenomeRNAi human phenotypes for KCNK16:
Animal Model Products
-
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-
ViGene Biosciences lentiviral particle packaged cDNA for KCNK16 gene
-
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- Search ViGene Biosciences for KCNK16
CRISPR Products
-
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-
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miRNA for KCNK16 Gene
- miRTarBase miRNAs that target KCNK16
miRNA Products
- Search ViGene Biosciences for KCNK16
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for KCNK16 gene
Cell Line Products
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Horizon Cell Lines for KCNK16
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK16 Gene
Localization for KCNK16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK16 Gene
- Membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNK16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Cardiac conduction | ||
| 3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK16 Gene
7 Reactome pathways for KCNK16 Gene
13 Qiagen pathways for KCNK16 Gene
Interacting Proteins for KCNK16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IDA | 11263999 |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0071805 | potassium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNK16 Gene
Drugs & Compounds for KCNK16 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK16 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK16 Gene
mRNA/cDNA for KCNK16 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK16 Gene
- Potassium channel, subfamily K, member 16:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KCNK16
-
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-
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||
| SP5: |
Expression for KCNK16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
mRNA differential expression in normal tissues according to GTEx for KCNK16 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK16 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNK16 Gene:
KCNK16SOURCE GeneReport for Unigene cluster for KCNK16 Gene:
Hs.287765mRNA Expression by UniProt/SwissProt for KCNK16 Gene:
Q96T55-KCNKG_HUMANEvidence on tissue expression from TISSUES for KCNK16 Gene
- Pancreas(4.4)
Primer Products
-
OriGene qPCR primer pairs for KCNK16
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK16 Gene
Orthologs for KCNK16 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | KCNK16 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNK16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnk16 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk16 34 16 35 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK16 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KCNK16 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNK16 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNK16 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KCNK16 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnk16 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101882139 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6929 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for KCNK16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNK16 Gene
Paralogs for KCNK16 Gene
(8) SIMAP similar genes for KCNK16 Gene using alignment to 2 proteins:
Variants for KCNK16 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000334771 | -- | 39,321,888(+) | GGGAT(A/G)TGAGC | intron-variant | |
| rs1000401187 | -- | 39,320,251(+) | CTTAA(G/T)ATGTG | intron-variant | |
| rs1000479957 | -- | 39,315,723(+) | CACTG(C/T)GTTGG | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1000708011 | -- | 39,321,652(+) | CAACA(C/G)CTGGT | intron-variant | |
| rs1000855572 | -- | 39,322,075(+) | GTTAT(G/T)CTTGT | intron-variant |
Relevant External Links for KCNK16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNK16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK16 Gene
Disorders for KCNK16 Gene
Relevant External Links for KCNK16
No disorders were found for KCNK16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK16 Gene
Publications for KCNK16 Gene
- Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PMID: 12724142) Han J. … Kim D. (Am. J. Physiol. 2003) 3 4 22 64
- Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C. … Lesage F. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 46 64
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J. … Thomas D. (Br. J. Pharmacol. 2008) 3 4 64
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
Products for KCNK16 Gene
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




