Aliases for KCNK15 Gene
Aliases for KCNK15 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 15 2 3 5
- Potassium Channel, Two Pore Domain Subfamily K, Member 15 2 3
- Acid-Sensitive Potassium Channel Protein TASK-5 3 4
- TWIK-Related Acid-Sensitive K(+) Channel 5 3 4
- Two Pore Potassium Channel KT3.3 3 4
- Two Pore K(+) Channel KT3.3 3 4
- TASK5 3 4
- Potassium Channel, Subfamily K, Member 15 2
- Potassium Channel, Subfamily K, Member 14 3
External Ids for KCNK15 Gene
- HGNC: 13814
- Entrez Gene: 60598
- Ensembl: ENSG00000124249
- OMIM: 607368
- UniProtKB: Q9H427
Previous HGNC Symbols for KCNK15 Gene
- KCNK11
- KCNK14
Previous GeneCards Identifiers for KCNK15 Gene
- GC20P043102
- GC20P044012
- GC20P044059
- GC20P042807
- GC20P043374
- GC20P040116
Summaries for KCNK15 Gene
-
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK15 Gene
KCNK15 (Potassium Two Pore Domain Channel Subfamily K Member 15) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK9.
UniProtKB/Swiss-Prot for KCNK15 Gene
-
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK15 Gene
Genomics for KCNK15 Gene
Regulatory Elements for KCNK15 Gene
Enhancers for KCNK15 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNK15 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for KCNK15 Gene
- Chromosome:
- 20
- Start:
- 44,745,780 bp from pter
- End:
- 44,752,313 bp from pter
- Size:
- 6,534 bases
- Orientation:
- Plus strand
Genomic View for KCNK15 Gene
Genes around KCNK15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
KCNK15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK15 Gene
Proteins for KCNK15 Gene
-
Protein details for KCNK15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H427-KCNKF_HUMAN
- Recommended name:
- Potassium channel subfamily K member 15
- Protein Accession:
- Q9H427
- Q52LL3
- Q9HBC8
Protein attributes for KCNK15 Gene
- Size:
- 330 amino acids
- Molecular mass:
- 36130 Da
- Quaternary structure:
-
- Heterodimer.
Protein Expression for KCNK15 Gene
Post-translational modifications for KCNK15 Gene
Other Protein References for KCNK15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KCNK15
- Novus Biologicals Antibodies for KCNK15
- Invitrogen Antibodies for KCNK15
- antibodies-online Antibodies for KCNK15: See all 22
- GeneTex KCNK15 antibody for KCNK15
Protein Products
-
OriGene Purified Proteins for KCNK15
- Search Origene for MassSpec and Protein Over-expression Lysates for KCNK15
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- Search GeneTex for Proteins for KCNK15
Assay Products
No data available for DME Specific Peptides for KCNK15 Gene
Domains & Families for KCNK15 Gene
Gene Families for KCNK15 Gene
Protein Domains for KCNK15 Gene
Suggested Antigen Peptide Sequences for KCNK15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H427UniProtKB/Swiss-Prot:
KCNKF_HUMAN :- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
- Domain:
-
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK15 Gene
Molecular function for KCNK15 Gene
- UniProtKB/Swiss-Prot Function:
- Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | NOT voltage-gated ion channel activity | IDA | 11749039 |
| GO:0005267 | potassium channel activity | TAS | -- |
Phenotypes for KCNK15 Gene
- GenomeRNAi human phenotypes for KCNK15:
Animal Model Products
-
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-
ViGene Biosciences lentiviral particle packaged cDNA for KCNK15 gene
-
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CRISPR Products
-
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-
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miRNA Products
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Inhibitory RNA Products
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-
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Cell Line Products
-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK15 Gene
Localization for KCNK15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK15 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNK15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 4 | Cardiac conduction | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK15 Gene
3 Reactome pathways for KCNK15 Gene
13 Qiagen pathways for KCNK15 Gene
Interacting Proteins for KCNK15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
| GO:0061337 | cardiac conduction | TAS | -- |
No data available for SIGNOR curated interactions for KCNK15 Gene
Drugs & Compounds for KCNK15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Halothane | Approved, Vet_approved | Pharma | Activator, antagonist | 2 | ||
| BL 1249 | Pharma | Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener | 0 | |||
| DMP 543 | Pharma | K+ channel blocker and potent ACh release enhancer | 0 | |||
| ML365 | Pharma | Potent and selective TASK-1 channel blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK15 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK15 Gene
mRNA/cDNA for KCNK15 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNK15
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK15
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
Expression for KCNK15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for KCNK15 Gene
This gene is overexpressed in Artery - Aorta (x11.9) and Artery - Coronary (x7.0).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK15 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KCNK15 Gene:
KCNK15SOURCE GeneReport for Unigene cluster for KCNK15 Gene:
Hs.528664mRNA Expression by UniProt/SwissProt for KCNK15 Gene:
Q9H427-KCNKF_HUMAN
Tissue specificity:
Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.
Evidence on tissue expression from TISSUES for KCNK15 Gene
- Nervous system(4.3)
- Intestine(4.1)
Primer Products
-
OriGene qPCR primer pairs for KCNK15
-
OriGene qPCR primer pairs and template standards for KCNK15
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK15 Gene
Orthologs for KCNK15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK15 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNK15 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNK15 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk15 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnk15 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNK15 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNK15 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KCNK15 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | kcnk15 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9637 36 |
|
|
|
| CG9361 36 |
|
|
|||
| Task7 35 |
|
ManyToMany | |||
| Task6 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | twk-4 36 |
|
|
|
| sup-9 35 |
|
ManyToMany | |||
| twk-20 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for KCNK15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for KCNK15 Gene
Variants for KCNK15 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK15 Gene
- KCNKF_HUMAN-Q9H427
- Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000068025 | -- | 44,752,084(+) | CTCCA(C/T)TCTGA | utr-variant-3-prime | |
| rs1000248497 | -- | 44,746,114(+) | CTCCA(A/G)GCTGA | nc-transcript-variant, reference, synonymous-codon | |
| rs1000981711 | -- | 44,745,707(+) | TGAAC(A/C)CCGGG | intron-variant, upstream-variant-2KB, reference, missense | |
| rs1001375703 | -- | 44,746,632(+) | TCGGC(C/T)TTATC | intron-variant, upstream-variant-2KB | |
| rs1002054363 | -- | 44,752,225(+) | GGCCT(C/T)GGAGA | utr-variant-3-prime |
Residual Variation Intolerance Score:
58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.71;
66.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNK15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNK15
Disorders for KCNK15 Gene
Relevant External Links for KCNK15
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- KCNK15
No disorders were found for KCNK15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK15 Gene
Publications for KCNK15 Gene
- TASK-5, a new member of the tandem-pore K(+) channel family. (PMID: 11409881) Kim D. … Gnatenco C. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
- KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 2 3 4 64
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
- TASK-5, a novel member of the tandem pore K+ channel family. (PMID: 11680614) Ashmole I. … Stanfield P.R. (Pflugers Arch. 2001) 3 4 64
- Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. (PMID: 11749039) Karschin C. … Karschin A. (Mol. Cell. Neurosci. 2001) 3 4 64
Products for KCNK15 Gene
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- Novus Biologicals Antibodies for KCNK15
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer