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Aliases for KCNK15 Gene

Aliases for KCNK15 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 15 2 3
  • TASK5 3 4 6
  • Acid-Sensitive Potassium Channel Protein TASK-5 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 5 3 4
  • Two Pore Potassium Channel KT3.3 3 4
  • Two Pore K(+) Channel KT3.3 3 4
  • Potassium Channel, Subfamily K, Member 15 2
  • Potassium Channel, Subfamily K, Member 14 3
  • Potassium Channel Subfamily K Member 15 3
  • DJ781B1.1 3
  • K2p15.1 3
  • TASK-5 3
  • KCNK11 3
  • KCNK14 3
  • KT3.3 3

External Ids for KCNK15 Gene

Previous HGNC Symbols for KCNK15 Gene

  • KCNK11
  • KCNK14

Previous GeneCards Identifiers for KCNK15 Gene

  • GC20P043102
  • GC20P044012
  • GC20P044059
  • GC20P042807
  • GC20P043374
  • GC20P040116

Summaries for KCNK15 Gene

Entrez Gene Summary for KCNK15 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK15 Gene

KCNK15 (Potassium Channel, Two Pore Domain Subfamily K, Member 15) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK15 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel

Tocris Summary for KCNK15 Gene

Gene Wiki entry for KCNK15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK15 Gene

Genomics for KCNK15 Gene

Regulatory Elements for KCNK15 Gene

Genomic Location for KCNK15 Gene

Start:
44,745,780 bp from pter
End:
44,752,313 bp from pter
Size:
6,534 bases
Orientation:
Plus strand

Genomic View for KCNK15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK15 Gene

Proteins for KCNK15 Gene

  • Protein details for KCNK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H427-KCNKF_HUMAN
    Recommended name:
    Potassium channel subfamily K member 15
    Protein Accession:
    Q9H427
    Secondary Accessions:
    • Q52LL3
    • Q9HBC8

    Protein attributes for KCNK15 Gene

    Size:
    330 amino acids
    Molecular mass:
    36130 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK15 Gene

Proteomics data for KCNK15 Gene at MOPED

Post-translational modifications for KCNK15 Gene

No Post-translational modifications

Other Protein References for KCNK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK15 Gene

Domains for KCNK15 Gene

Gene Families for KCNK15 Gene

HGNC:
  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P
IUPHAR :

Suggested Antigen Peptide Sequences for KCNK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H427

UniProtKB/Swiss-Prot:

KCNKF_HUMAN :
  • Q9H427
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK15: view

Function for KCNK15 Gene

Molecular function for KCNK15 Gene

UniProtKB/Swiss-Prot Function: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel

Gene Ontology (GO) - Molecular Function for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 NOT voltage-gated ion channel activity IDA 11749039
GO:0005267 potassium channel activity --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK15: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK15 Gene

Localization for KCNK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK15 Gene COMPARTMENTS Subcellular localization image for KCNK15 gene
Compartment Confidence
plasma membrane 3
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK15: view

Pathways for KCNK15 Gene

genes like me logo Genes that share pathways with KCNK15: view

Interacting Proteins for KCNK15 Gene

Gene Ontology (GO) - Biological Process for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK15: view

Compounds for KCNK15 Gene

(5) Tocris Compounds for KCNK15 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(1) IUPHAR Ligand for KCNK15 Gene

Ligand Type Action Affinity Pubmed IDs
halothane Activator None
genes like me logo Genes that share compounds with KCNK15: view

Transcripts for KCNK15 Gene

mRNA/cDNA for KCNK15 Gene

(32) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK15 Gene

Potassium channel, subfamily K, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK15 Gene

No ASD Table

Relevant External Links for KCNK15 Gene

GeneLoc Exon Structure for
KCNK15
ECgene alternative splicing isoforms for
KCNK15

Expression for KCNK15 Gene

mRNA expression in normal human tissues for KCNK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK15 Gene

This gene is overexpressed in Artery - Aorta (11.9) and Artery - Coronary (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK15 Gene

SOURCE GeneReport for Unigene cluster for KCNK15 Gene Hs.528664

mRNA Expression by UniProt/SwissProt for KCNK15 Gene

Q9H427-KCNKF_HUMAN
Tissue specificity: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.
genes like me logo Genes that share expressions with KCNK15: view

Orthologs for KCNK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK15 35
  • 98.18 (n)
  • 96.06 (a)
KCNK15 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK15 35
  • 87.02 (n)
  • 82.55 (a)
KCNK15 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK15 35
  • 88.18 (n)
  • 81.21 (a)
KCNK15 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk15 35
  • 81.83 (n)
  • 76.95 (a)
Kcnk15 16
Kcnk15 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK15 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk15 35
  • 81.38 (n)
  • 79.05 (a)
chicken
(Gallus gallus)
Aves KCNK15 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK15 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk15 35
  • 73.66 (n)
  • 69.14 (a)
kcnk15 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Task6 36
  • 33 (a)
ManyToMany
Task7 36
  • 37 (a)
ManyToMany
CG9637 37
  • 50 (a)
CG9361 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea sup-9 36
  • 41 (a)
ManyToMany
twk-20 36
  • 31 (a)
ManyToMany
twk-4 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for KCNK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNK15 Gene

ENSEMBL:
Gene Tree for KCNK15 (if available)
TreeFam:
Gene Tree for KCNK15 (if available)

Paralogs for KCNK15 Gene

Selected SIMAP similar genes for KCNK15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK15: view

Variants for KCNK15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK15 Gene

Q9H427-KCNKF_HUMAN
Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C

Sequence variations from dbSNP and Humsavar for KCNK15 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1107745 -- 44,751,232(-) TTGCA(G/T)CGAAG utr-variant-3-prime
rs1111032 - 44,750,129(+) CATAG(A/G)GTACG reference, missense
rs1884672 -- 44,746,615(+) TAAAA(C/T)AGTGT intron-variant
rs3803988 -- 44,749,868(+) TTGCC(G/T)CAAGT intron-variant
rs3834659 -- 44,746,199(+) TGAGC(-/C)GCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK15 Gene

Variant ID Type Subtype PubMed ID
nsv458985 CNV Gain 19166990

Relevant External Links for KCNK15 Gene

HapMap Linkage Disequilibrium report
KCNK15

Disorders for KCNK15 Gene

No disorders were found for KCNK15 Gene.

No data available for UniProtKB/Swiss-Prot for KCNK15 Gene

Publications for KCNK15 Gene

  1. TASK-5, a new member of the tandem-pore K(+) channel family. (PMID: 11409881) Kim D. … Gnatenco C. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 2 3 4
  3. TASK-5, a novel member of the tandem pore K+ channel family. (PMID: 11680614) Ashmole I. … Stanfield P.R. (Pflugers Arch. 2001) 3 4
  4. Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. (PMID: 11749039) Karschin C. … Karschin A. (Mol. Cell. Neurosci. 2001) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for KCNK15 Gene

  • antibodies-online peptides for KCNK15
  • antibodies-online antibodies for KCNK15
  • antibodies-online kits for KCNK15

Sources for KCNK15 Gene

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