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Aliases for KCNK15 Gene

Aliases for KCNK15 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 15 2 3
  • Acid-Sensitive Potassium Channel Protein TASK-5 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 5 3 4
  • Two Pore Potassium Channel KT3.3 3 4
  • Two Pore K(+) Channel KT3.3 3 4
  • TASK5 3 4
  • Potassium Channel, Subfamily K, Member 15 2
  • Potassium Channel, Subfamily K, Member 14 3
  • DJ781B1.1 3
  • K2p15.1 3
  • TASK-5 3
  • KCNK11 3
  • KCNK14 3
  • KT3.3 3

External Ids for KCNK15 Gene

Previous HGNC Symbols for KCNK15 Gene

  • KCNK11
  • KCNK14

Previous GeneCards Identifiers for KCNK15 Gene

  • GC20P043102
  • GC20P044012
  • GC20P044059
  • GC20P042807
  • GC20P043374
  • GC20P040116

Summaries for KCNK15 Gene

Entrez Gene Summary for KCNK15 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK15 Gene

KCNK15 (Potassium Channel, Two Pore Domain Subfamily K, Member 15) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK15 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel

Tocris Summary for KCNK15 Gene

Gene Wiki entry for KCNK15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK15 Gene

Genomics for KCNK15 Gene

Regulatory Elements for KCNK15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK15 Gene

Chromosome:
20
Start:
44,745,780 bp from pter
End:
44,752,313 bp from pter
Size:
6,534 bases
Orientation:
Plus strand

Genomic View for KCNK15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK15 Gene

Proteins for KCNK15 Gene

  • Protein details for KCNK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H427-KCNKF_HUMAN
    Recommended name:
    Potassium channel subfamily K member 15
    Protein Accession:
    Q9H427
    Secondary Accessions:
    • Q52LL3
    • Q9HBC8

    Protein attributes for KCNK15 Gene

    Size:
    330 amino acids
    Molecular mass:
    36130 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK15 Gene

Proteomics data for KCNK15 Gene at MOPED

Post-translational modifications for KCNK15 Gene

No Post-translational modifications

Other Protein References for KCNK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK15 Gene

Domains & Families for KCNK15 Gene

Suggested Antigen Peptide Sequences for KCNK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H427

UniProtKB/Swiss-Prot:

KCNKF_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK15: view

Function for KCNK15 Gene

Molecular function for KCNK15 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel

Gene Ontology (GO) - Molecular Function for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 NOT voltage-gated ion channel activity IDA 11749039
GO:0005267 potassium channel activity --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK15: view

Phenotypes for KCNK15 Gene

GenomeRNAi human phenotypes for KCNK15:
genes like me logo Genes that share phenotypes with KCNK15: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK15 Gene

Localization for KCNK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK15 Gene COMPARTMENTS Subcellular localization image for KCNK15 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNK15: view

Pathways & Interactions for KCNK15 Gene

genes like me logo Genes that share pathways with KCNK15: view

Interacting Proteins for KCNK15 Gene

Gene Ontology (GO) - Biological Process for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK15: view

No data available for SIGNOR curated interactions for KCNK15 Gene

Drugs & Compounds for KCNK15 Gene

(1) Drugs for KCNK15 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved Pharma Activator, antagonist 1

(5) Additional Compounds for KCNK15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
YS-035 hydrochloride
89805-39-0
genes like me logo Genes that share compounds with KCNK15: view

Transcripts for KCNK15 Gene

mRNA/cDNA for KCNK15 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK15 Gene

Potassium channel, subfamily K, member 15:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK15 Gene

No ASD Table

Relevant External Links for KCNK15 Gene

GeneLoc Exon Structure for
KCNK15
ECgene alternative splicing isoforms for
KCNK15

Expression for KCNK15 Gene

mRNA expression in normal human tissues for KCNK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK15 Gene

This gene is overexpressed in Artery - Aorta (x11.9) and Artery - Coronary (x7.0).

Protein differential expression in normal tissues from HIPED for KCNK15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK15 Gene



SOURCE GeneReport for Unigene cluster for KCNK15 Gene Hs.528664

mRNA Expression by UniProt/SwissProt for KCNK15 Gene

Q9H427-KCNKF_HUMAN
Tissue specificity: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.
genes like me logo Genes that share expression patterns with KCNK15: view

Protein tissue co-expression partners for KCNK15 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KCNK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK15 35
  • 87.02 (n)
  • 82.55 (a)
KCNK15 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK15 35
  • 88.18 (n)
  • 81.21 (a)
KCNK15 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk15 35
  • 81.83 (n)
  • 76.95 (a)
Kcnk15 16
Kcnk15 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK15 35
  • 98.18 (n)
  • 96.06 (a)
KCNK15 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk15 35
  • 81.38 (n)
  • 79.05 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK15 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK15 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK15 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk15 35
  • 73.66 (n)
  • 69.14 (a)
kcnk15 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9361 37
  • 48 (a)
CG9637 37
  • 50 (a)
Task6 36
  • 33 (a)
ManyToMany
Task7 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea twk-4 37
  • 42 (a)
sup-9 36
  • 41 (a)
ManyToMany
twk-20 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for KCNK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNK15 Gene

ENSEMBL:
Gene Tree for KCNK15 (if available)
TreeFam:
Gene Tree for KCNK15 (if available)

Paralogs for KCNK15 Gene

(3) SIMAP similar genes for KCNK15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK15: view

Variants for KCNK15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK15 Gene

Q9H427-KCNKF_HUMAN
Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C

Sequence variations from dbSNP and Humsavar for KCNK15 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1107745 -- 44,751,232(-) TTGCA(G/T)CGAAG utr-variant-3-prime
rs1111032 - 44,750,129(+) CATAG(A/G)GTACG reference, missense
rs1884672 -- 44,746,615(+) TAAAA(C/T)AGTGT intron-variant
rs3803988 -- 44,749,868(+) TTGCC(A/G/T)CAAGT intron-variant
rs3834659 -- 44,746,199(+) TGAGC(-/C)GCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK15 Gene

Variant ID Type Subtype PubMed ID
nsv458985 CNV Gain 19166990

Variation tolerance for KCNK15 Gene

Residual Variation Intolerance Score: 58.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK15 Gene

HapMap Linkage Disequilibrium report
KCNK15

Disorders for KCNK15 Gene

Relevant External Links for KCNK15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK15
genes like me logo Genes that share disorders with KCNK15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK15 Gene

Publications for KCNK15 Gene

  1. Acoustic trauma evokes hyperactivity and changes in gene expression in guinea-pig auditory brainstem. (PMID: 20525074) Dong S. … Robertson D. (Eur. J. Neurosci. 2010) 23 67
  2. Changes in neuronal activity and gene expression in guinea-pig auditory brainstem after unilateral partial hearing loss. (PMID: 19356697) Dong S. … Robertson D. (Neuroscience 2009) 23 67
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 67
  4. TASK-5, a new member of the tandem-pore K(+) channel family. (PMID: 11409881) Kim D. … Gnatenco C. (Biochem. Biophys. Res. Commun. 2001) 2 67
  5. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 2 67

Products for KCNK15 Gene

Sources for KCNK15 Gene

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