Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK15 Gene

Aliases for KCNK15 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 15 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 15 2 3
  • Acid-Sensitive Potassium Channel Protein TASK-5 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 5 3 4
  • Two Pore Potassium Channel KT3.3 3 4
  • Two Pore K(+) Channel KT3.3 3 4
  • TASK5 3 4
  • Potassium Channel, Subfamily K, Member 15 2
  • Potassium Channel, Subfamily K, Member 14 3
  • Potassium Channel Subfamily K Member 15 3
  • DJ781B1.1 3
  • K2p15.1 3
  • TASK-5 3
  • KCNK11 3
  • KCNK14 3
  • KT3.3 3

External Ids for KCNK15 Gene

Previous HGNC Symbols for KCNK15 Gene

  • KCNK11
  • KCNK14

Previous GeneCards Identifiers for KCNK15 Gene

  • GC20P043102
  • GC20P044012
  • GC20P044059
  • GC20P042807
  • GC20P043374
  • GC20P040116

Summaries for KCNK15 Gene

Entrez Gene Summary for KCNK15 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK15 Gene

KCNK15 (Potassium Two Pore Domain Channel Subfamily K Member 15) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK9.

UniProtKB/Swiss-Prot for KCNK15 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Tocris Summary for KCNK15 Gene

Gene Wiki entry for KCNK15 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK15 Gene

Genomics for KCNK15 Gene

Regulatory Elements for KCNK15 Gene

Enhancers for KCNK15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G044690 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.8 -51.7 -51738 6.4 FOXA2 MLX ARID4B SIN3A SLC30A9 FOS DEK SP5 ZHX2 MXD4 LINC01260 WISP2 KCNK15 KCNK15-AS1 ADA SERINC3 PKIG PIGT PABPC1L ENSG00000283440
GH20G044683 1.4 Ensembl ENCODE dbSUPER 16 -61.1 -61069 2.5 SIN3A ZNF48 YY1 SLC30A9 ELK1 ZNF143 DEK MIER2 REST PPARG LINC01260 ADA KCNK15 WISP2 KCNK15-AS1 SERINC3 PKIG OSER1-AS1 ENSG00000283440
GH20G044745 1.5 Ensembl ENCODE dbSUPER 10.2 +1.2 1229 2.7 PKNOX1 CREB3L1 ARNT SIN3A BRCA1 ZNF2 ZNF48 ZNF302 ZNF143 SMARCB1 KCNK15 GC20P044749 ENSG00000276223
GH20G044702 1.3 Ensembl ENCODE dbSUPER 11.7 -41.0 -40966 4.8 PKNOX1 YBX1 RARA ZNF366 FOS ZBTB11 USF2 NR2F2 RAD51 SMARCA4 KCNK15 KCNK15-AS1 LINC01260 HSPD1P21 WISP2
GH20G044670 1.2 Ensembl ENCODE dbSUPER 11.5 -73.9 -73850 2.3 RFX1 MTA2 RNF2 TEAD4 GATAD2B BMI1 SMARCA4 TARDBP IKZF1 NBN LINC01260 KCNK15-AS1 KCNK15 PKIG ADA OSER1-AS1 ENSG00000283440
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNK15 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137580 120 601 GTF2F1 SUZ12 MAX SIN3A RBBP5 E2F1 POLR2A HSF1 PCBP1 E2F6

Genomic Location for KCNK15 Gene

Chromosome:
20
Start:
44,745,780 bp from pter
End:
44,752,313 bp from pter
Size:
6,534 bases
Orientation:
Plus strand

Genomic View for KCNK15 Gene

Genes around KCNK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK15 Gene

Proteins for KCNK15 Gene

  • Protein details for KCNK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H427-KCNKF_HUMAN
    Recommended name:
    Potassium channel subfamily K member 15
    Protein Accession:
    Q9H427
    Secondary Accessions:
    • Q52LL3
    • Q9HBC8

    Protein attributes for KCNK15 Gene

    Size:
    330 amino acids
    Molecular mass:
    36130 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK15 Gene

Post-translational modifications for KCNK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK15 Gene

Domains & Families for KCNK15 Gene

Gene Families for KCNK15 Gene

Suggested Antigen Peptide Sequences for KCNK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H427

UniProtKB/Swiss-Prot:

KCNKF_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK15: view

Function for KCNK15 Gene

Molecular function for KCNK15 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Gene Ontology (GO) - Molecular Function for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 NOT voltage-gated ion channel activity IDA 11749039
GO:0005267 potassium channel activity TAS --
genes like me logo Genes that share ontologies with KCNK15: view

Phenotypes for KCNK15 Gene

genes like me logo Genes that share phenotypes with KCNK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK15

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK15 Gene

Localization for KCNK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK15 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK15: view

Pathways & Interactions for KCNK15 Gene

genes like me logo Genes that share pathways with KCNK15: view

Gene Ontology (GO) - Biological Process for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0061337 cardiac conduction TAS --
genes like me logo Genes that share ontologies with KCNK15: view

No data available for SIGNOR curated interactions for KCNK15 Gene

Drugs & Compounds for KCNK15 Gene

(4) Drugs for KCNK15 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, antagonist 2
BL 1249 Pharma Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener 0
DMP 543 Pharma K+ channel blocker and potent ACh release enhancer 0
ML365 Pharma Potent and selective TASK-1 channel blocker 0

(2) Additional Compounds for KCNK15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK15 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3
genes like me logo Genes that share compounds with KCNK15: view

Transcripts for KCNK15 Gene

mRNA/cDNA for KCNK15 Gene

Unigene Clusters for KCNK15 Gene

Potassium channel, subfamily K, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK15 Gene

No ASD Table

Relevant External Links for KCNK15 Gene

GeneLoc Exon Structure for
KCNK15
ECgene alternative splicing isoforms for
KCNK15

Expression for KCNK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK15 Gene

This gene is overexpressed in Artery - Aorta (x11.9) and Artery - Coronary (x7.0).

Protein differential expression in normal tissues from HIPED for KCNK15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK15 Gene



Protein tissue co-expression partners for KCNK15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK15 Gene:

KCNK15

SOURCE GeneReport for Unigene cluster for KCNK15 Gene:

Hs.528664

mRNA Expression by UniProt/SwissProt for KCNK15 Gene:

Q9H427-KCNKF_HUMAN
Tissue specificity: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.

Evidence on tissue expression from TISSUES for KCNK15 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with KCNK15: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK15 Gene

Orthologs for KCNK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK15 34 35
  • 98.18 (n)
dog
(Canis familiaris)
Mammalia KCNK15 34 35
  • 88.18 (n)
cow
(Bos Taurus)
Mammalia KCNK15 34 35
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia Kcnk15 34 16 35
  • 81.83 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk15 34
  • 81.38 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNK15 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK15 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK15 35
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk15 34 35
  • 73.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9637 36
  • 50 (a)
CG9361 36
  • 48 (a)
Task7 35
  • 37 (a)
ManyToMany
Task6 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea twk-4 36
  • 42 (a)
sup-9 35
  • 41 (a)
ManyToMany
twk-20 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for KCNK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNK15 Gene

ENSEMBL:
Gene Tree for KCNK15 (if available)
TreeFam:
Gene Tree for KCNK15 (if available)

Paralogs for KCNK15 Gene

Paralogs for KCNK15 Gene

(3) SIMAP similar genes for KCNK15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK15: view

Variants for KCNK15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK15 Gene

KCNKF_HUMAN-Q9H427
Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.

Sequence variations from dbSNP and Humsavar for KCNK15 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000068025 -- 44,752,084(+) CTCCA(C/T)TCTGA utr-variant-3-prime
rs1000248497 -- 44,746,114(+) CTCCA(A/G)GCTGA nc-transcript-variant, reference, synonymous-codon
rs1000981711 -- 44,745,707(+) TGAAC(A/C)CCGGG intron-variant, upstream-variant-2KB, reference, missense
rs1001375703 -- 44,746,632(+) TCGGC(C/T)TTATC intron-variant, upstream-variant-2KB
rs1002054363 -- 44,752,225(+) GGCCT(C/T)GGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNK15 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv458985 CNV gain 19166990
nsv586076 CNV gain 21841781

Variation tolerance for KCNK15 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK15

Disorders for KCNK15 Gene

Relevant External Links for KCNK15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK15

No disorders were found for KCNK15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK15 Gene

Publications for KCNK15 Gene

  1. TASK-5, a new member of the tandem-pore K(+) channel family. (PMID: 11409881) Kim D. … Gnatenco C. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  2. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E. … Rudy B. (J. Neurophysiol. 2001) 2 3 4 64
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
  4. TASK-5, a novel member of the tandem pore K+ channel family. (PMID: 11680614) Ashmole I. … Stanfield P.R. (Pflugers Arch. 2001) 3 4 64
  5. Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system. (PMID: 11749039) Karschin C. … Karschin A. (Mol. Cell. Neurosci. 2001) 3 4 64

Products for KCNK15 Gene

Sources for KCNK15 Gene

Content
Loading form....