Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNK13 Gene

protein-coding GIFtS: 51
GCID: GC14P090528

potassium channel, subfamily K, member 13

Search for KCNK13
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 13¹ ²		Tandem Pore Domain Halothane-Inhibited Potassium Channel 1² ³
THIK-1¹ ² ³		K2P13.1 Potassium Channel²
THIK1¹ ² ⁵		Potassium Channel Subfamily K Member 13²
K2p13.1¹ ²		Tandem Pore Domain Potassium Channel THIK-1²

External Ids:	HGNC: 6275¹	Entrez Gene: 56659²	Ensembl: ENSG00000152315⁷	OMIM: 607367⁵	UniProtKB: Q9HB14³

Export aliases for KCNK13 gene to outside databases

Previous GC identifers: GC14P088033 GC14P084344 GC14P088518 GC14P089597 GC14P070702

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK13:

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming

domains. The product of this gene is an open channel that can be stimulated by arachidonic acid. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: KCNKD_HUMAN, Q9HB14

Function: Potassium channel displaying weak inward rectification in symmetrical K(+) solution (By similarity)

Gene Wiki entry for KCNK13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNK13 gene promoter:
AhR HOXA3 ATF-2 XBP-1 NF-kappaB Arnt PPAR-alpha FAC1 NF-kappaB2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNK13 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNK13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11 Ensembl cytogenetic band: 14q32.11 HGNC cytogenetic band: 14q32.11

KCNK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK13 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P090528: view genomic region (about GC identifiers)

Start:	90,528,108 bp from pter	End:	90,652,201 bp from pter
Size:	124,094 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNKD_HUMAN, Q9HB14 (See protein sequence)

Recommended Name: Potassium channel subfamily K member 13

Size: 408 amino acids; 45391 Da

Subunit: Homodimer (Potential)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Miscellaneous: The current is enhanced by arachidonic acid and inhibited by halothane (By similarity)

Secondary accessions: Q96E79

Explore the universe of human proteins at neXtProt for KCNK13: NX_Q9HB14

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HB14

KCNK13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071337.2

ENSEMBL proteins:

ENSP00000282146

Reactome Protein details: Q9HB14
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KCNK13 OriGene Custom Protein Services for KCNK13
	GenScript Custom Purified and Recombinant Proteins Services for KCNK13
	Novus Biologicals KCNK13 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KCNK13

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

KCNK13 for ontologies About GeneDecksing

KCNK13 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNK13
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCNK13
	GenScript Custom Superior Antibodies Services for KCNK13
	Novus Biologicals KCNK13 Antibodies
	Search for Antibodies for KCNK13 at Abcam
	Uscn Antibodies for KCNK13
	Search ThermoFisher Antibodies for KCNK13

Assay Products for KCNK13:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNK13
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KCNK13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNK13 for domains About GeneDecksing

3 InterPro domains/families:

IPR003280 2pore_dom_K_chnl

IPR005410 2pore_dom_K_chnl_THIK

IPR013099 Ion_trans_2

Graphical View of Domain Structure for InterPro Entry Q9HB14

ProtoNet protein and cluster: Q9HB14

3 Blocks protein families:

IPB003280 Two pore domain K+ channel signature

IPB005410 THIK K+ channel signature

IPB013099 Ion transport 2

UniProtKB/Swiss-Prot: KCNKD_HUMAN, Q9HB14

Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCNKD_HUMAN, Q9HB14

Function: Potassium channel displaying weak inward rectification in symmetrical K(+) solution (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: KCNK13 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNK13
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNK13:
		hsa-miR-3140-3p hsa-miR-186 hsa-miR-3121-3p hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: KCNK13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK13 (see all 7) OriGene shRNA RFP: KCNK13 OriGene siRNA: KCNK13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNK13

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCNK13

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNK13 (NM_022054)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNK13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK13

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNK13
		Search LifeMap BioReagents cell lines for KCNK13

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK13

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005267	potassium channel activity	TAS	--

KCNK13 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KCNK13:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

Sweet Taste Signaling	1.00	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.36
Cellular Effects of Sildenafil	0.46

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

MODY (Maturity-Onset Diabetes of Young)

0.41

Potassium Channels

Potassium Channels

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KCNK13

Potassium transporters- inward current

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK13 (see all 13)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

4 Reactome Pathways for KCNK13

	Potassium Channels
	Tandem pore domain halothane-inhibited K+ channel (THIK)
	Neuronal System
	Tandem pore domain potassium channels

KCNK13 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCNK13

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007268	synaptic transmission	TAS	--
GO:0071805	potassium ion transmembrane transport	--	--

KCNK13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNK13 available from Tocris Bioscience About this table

Compound	Action	CAS #
YS-035 hydrochloride	Inhibits K+ outward/pacemaker current	[33978-72-2]
DMP 543	K+ channel blocker and potent ACh release enhancer	[160588-45-4]

Search CenterWatch for drugs/clinical trials and news about KCNK13 / KCNKD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNK13 gene:

NM_022054.2

Unigene Cluster for KCNK13:

Potassium channel, subfamily K, member 13

Hs.510191 [show with all ESTs]

Unigene Representative Sequence: BC012779

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000282146(uc001xye.1)

miRNA Products:		OriGene 3'-UTR Clone: KCNK13 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNK13
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNK13:
		hsa-miR-3140-3p hsa-miR-186 hsa-miR-3121-3p hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: KCNK13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK13 (see all 7) OriGene shRNA RFP: KCNK13 OriGene siRNA: KCNK13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNK13

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNK13 (NM_022054)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNK13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK13

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNK13
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNK13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK13

Additional cDNA sequence:

AF287303.1 BC012779.2 EU978942.1

1 DOTS entry:

DT.75100365

12 AceView cDNA sequences:

BX283120 BE797552 AF287303 BC012779 AI825602 AI953140 NM_022054 BF589078

AW117567 AI653378 AI806646 BI908934

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNK13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KCNK13 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNK13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNK13

SOURCE GeneReport for Unigene cluster: Hs.510191

SABiosciences Custom PCR Arrays for KCNK13

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNK13
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNK13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK13

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNK13 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNK13¹	potassium channel, subfamily K, member 13	79.9(n) 81.66(a)		772210 XM_001235375.1 XP_001235376.1
lizard (Anolis carolinensis)	Reptilia	KCNK13⁶ KCNK12⁶	--	73(a) 59(a)	1 ↔ 1 possible ortholog	1(12716320-12778223) 1(254990917-254991252)
zebrafish (Danio rerio)	Actinopterygii	kcnk13a¹	potassium channel, subfamily K, member 13a	67.92(n) 70.43(a)		571467 NM_001110117.1 NP_001103587.1
worm (Caenorhabditis elegans)	Secernentea	twk-12³ twk-14¹	potassium channel protein³ Protein TWK-14¹	38(a)³ 47.84(n)¹ 37.46(a)¹		V(12390060-12391487)³ 179699¹ NM_073702.2¹ NP_506103.2¹

ENSEMBL Gene Tree for KCNK13 (if available)
TreeFam Gene Tree for KCNK13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNK13 gene

KCNK15² KCNK5² KCNK16² KCNK3² KCNK12² KCNK9² KCNK6² KCNK2²

KCNK18² KCNK17² KCNK10² KCNK7² KCNK4² KCNK1²

1 SIMAP similar gene for KCNK13 using alignment to 2 protein entries: KCNKD_HUMAN (see all proteins):

KCNK12

KCNK13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201796746^1,2		--	90526175(+)	`AAAGG-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs144879497^1,2		--	90526382(+)	`GGGTAC/TACGGG`	1	--	us2k¹		0	--	--	--	--
rs112482305^1,2	C,	--	90526401(+)	`TAAAATTCT/- TTCAA`	1	--	us2k¹		1		CSA	2
rs56845902^1,2	C	--	90526404(+)	`AATTCTTTC/- AACTT`	1	--	us2k¹		1		NA	2
rs144637382^1,2		--	90526470(+)	`CTCACC/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs186740559^1,2		--	90526484(+)	`ATACAC/TATGCA`	1	--	us2k¹		0	--	--	--	--
rs191991583^1,2		--	90526550(+)	`GGGCAC/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs138675853^1,2		--	90526592(+)	`AGCACC/TAGGGT`	1	--	us2k¹		0	--	--	--	--
rs140367148^1,2		--	90526755(+)	`GAAGAC/TGCCCA`	1	--	us2k¹		0	--	--	--	--
rs8008970^1,2	C,F,	--	90526839(+)	`CTGTGT/AGCGCG`	1	--	us2k¹		4		NA WA	124

HapMap Linkage Disequilibrium report for KCNK13 (90528108 - 90652201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNK13: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK13

DNA2.0 Custom Variant and Variant Library Synthesis for KCNK13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNK13 for disorders About MalaCards

KCNK13 for disorders About GeneDecksing

OMIM gene information: 607367 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: KCNK13 (1 document)

Export disorders for KCNK13 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNK13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCNK13)

Utopia: connect your pdf to the dynamic
world of online information

THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PubMed id 11060316)^{1, 2, 3, 9} Rajan S.... Derst C. (2001)
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)^{1, 3} Goldstein S.A....Rajan S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PubMed id 18209473)^{1, 9} Theilig F....Derst C. (2008)
Genomic variation associated with mortality among adu lts of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. (PubMed id 20400778)¹ Morrison A.C....Smith N.L. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)¹ Gierten J....Thomas D. (2008)
Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells. (PubMed id 16683720)¹ Fearon I.M....Nurse C.A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Potassium leak channels and the KCNK family of two-P-domain subunits. (PubMed id 11256078)¹ Goldstein S.A....Zilberberg N. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56659	HGNC: 6275	AceView: KCNK13	Ensembl:ENSG00000152315	euGenes: HUgn56659
ECgene: KCNK13	H-InvDB: KCNK13

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNK13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNK13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNK13 gene:
Search GeneIP for patents involving KCNK13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNK13
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KCNK13
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNK13		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNK13
	OriGene Protein Over-expression Lysate for KCNK13		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KCNK13		OriGene 3'-UTR Clone for KCNK13
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK13
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCNK13		OriGene Custom Protein Services for KCNK13
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNK13
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK13
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK13
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNK13
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK13
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNK13

	GenScript Custom Purified and Recombinant Proteins Services for KCNK13		GenScript cDNA clones with any tag delivered in your preferred vector for KCNK13
	GenScript Custom Assay Services for KCNK13		GenScript Custom Superior Antibodies Services for KCNK13
	GenScript Custom overexpressing Cell Line Services for KCNK13		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNK13 promoter
	Search Chromatin IP Primers for KCNK13
	RT² qPCR Primer Assay in human, mouse, rat KCNK13
	Search GNC Networks for KCNK13
	SABiosciences PCR Arrays including human, mouse, rat KCNK13

Tocris compounds for KCNK13

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCNK13 antibodies
	KCNK13 lysates

	Search for Antibodies for KCNK13 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KCNK13
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

KCNK13 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for KCNK13

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK13

	SwitchGear 3'UTR luciferase reporter plasmids for KCNK13
	SwitchGear Promoter luciferase reporter plasmids for KCNK13

Search ThermoFisher Antibodies for KCNK13

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK13

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCNK13 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KCNK13 Gene

potassium channel, subfamily K, member 13

Aliases
for KCNK13 gene

Summaries
for KCNK13 gene

Genomic Views
for KCNK13 gene

Proteins
for KCNK13 gene

Protein Domains /
Families
for KCNK13 gene

Function
for KCNK13 gene

Pathways & Interactions
for KCNK13 gene

Drugs & Compounds
for KCNK13 gene

Transcripts
for KCNK13 gene

Expression
for KCNK13 gene

Orthologs
for KCNK13 gene

Paralogs
for KCNK13 gene

Genomic Variants
for KCNK13 gene

Disorders / Diseases
for KCNK13 gene

Publications
for KCNK13 gene

External Searches for KCNK13 gene

Genome Databases showing KCNK13 gene

Other Databases showing KCNK13 gene

Specialized Databases showing KCNK13 gene

Intellectual Property
for KCNK13 gene

Products
for KCNK13 gene

View Random Gene

Advanced Search

Export list of displayed genes

KCNK13 Gene

potassium channel, subfamily K, member 13

Aliasesfor KCNK13 gene

Summariesfor KCNK13 gene

Genomic Viewsfor KCNK13 gene

Proteinsfor KCNK13 gene

Protein Domains /Familiesfor KCNK13 gene

Functionfor KCNK13 gene

Pathways & Interactionsfor KCNK13 gene

Drugs & Compoundsfor KCNK13 gene

Transcriptsfor KCNK13 gene

Expression for KCNK13 gene

Orthologsfor KCNK13 gene

Paralogsfor KCNK13 gene

Genomic Variantsfor KCNK13 gene

Disorders / Diseasesfor KCNK13 gene

Publicationsfor KCNK13 gene

External Searches for KCNK13 gene

Genome Databases showing KCNK13 gene

Other Databases showing KCNK13 gene

Specialized Databases showing KCNK13 gene

Intellectual Propertyfor KCNK13 gene

Productsfor KCNK13 gene

View Random Gene

Aliases
for KCNK13 gene

Summaries
for KCNK13 gene

Genomic Views
for KCNK13 gene

Proteins
for KCNK13 gene

Protein Domains /
Families
for KCNK13 gene

Function
for KCNK13 gene

Pathways & Interactions
for KCNK13 gene

Drugs & Compounds
for KCNK13 gene

Transcripts
for KCNK13 gene

Expression
for KCNK13 gene

Orthologs
for KCNK13 gene

Paralogs
for KCNK13 gene

Genomic Variants
for KCNK13 gene

Disorders / Diseases
for KCNK13 gene

Publications
for KCNK13 gene

Intellectual Property
for KCNK13 gene

Products
for KCNK13 gene