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Aliases for KCNK13 Gene

Aliases for KCNK13 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 13 2 3 5
  • Tandem Pore Domain Halothane-Inhibited Potassium Channel 1 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 13 2 3
  • Potassium Channel, Subfamily K, Member 13 2 3
  • THIK-1 3 4
  • Tandem Pore Domain Potassium Channel THIK-1 3
  • Potassium Channel Subfamily K Member 13 3
  • K2P13.1 Potassium Channel 3
  • K2p13.1 3
  • THIK1 3

External Ids for KCNK13 Gene

Previous GeneCards Identifiers for KCNK13 Gene

  • GC14P088033
  • GC14P084344
  • GC14P088518
  • GC14P089597
  • GC14P090528
  • GC14P070702

Summaries for KCNK13 Gene

Entrez Gene Summary for KCNK13 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]

GeneCards Summary for KCNK13 Gene

KCNK13 (Potassium Two Pore Domain Channel Subfamily K Member 13) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK12.

UniProtKB/Swiss-Prot for KCNK13 Gene

  • Potassium channel displaying weak inward rectification in symmetrical K(+) solution.

Tocris Summary for KCNK13 Gene

Gene Wiki entry for KCNK13 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK13 Gene

Genomics for KCNK13 Gene

Regulatory Elements for KCNK13 Gene

Enhancers for KCNK13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G090087 1.3 FANTOM5 Ensembl ENCODE 16 +25.9 25876 0.3 SOX13 CEBPG ZNF644 YY1 POLR2A GATAD2A HMG20B TEAD1 HLF FOXA3 KCNK13 GLRXP2
GH14G090094 0.5 FANTOM5 29 +32.7 32703 0.3 ZFHX2 KCNK13 GLRXP2
GH14G089921 1.2 Ensembl ENCODE 10.5 -139.5 -139542 2.1 PKNOX1 SIN3A FEZF1 ZNF2 FOS TSHZ1 MAFF MYNN PBX2 KDM1A KCNK13 TDP1 ENSG00000259053 RAB42P1
GH14G090300 1.4 Ensembl ENCODE dbSUPER 8.9 +241.5 241477 5.3 FOXA2 MLX ARID4B RAD21 RARA YY1 ELK1 GATA2 ZNF366 PCBP1 NRDE2 CALM1 RPS18P2 KCNK13 PIR47953 PIR41665
GH14G089953 1.1 ENCODE 10.8 -105.8 -105825 4.7 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 TDP1 KCNK13 GC14M091544
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNK13 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071922 335 601 CTCF ZNF777 SUZ12 CBX2 ZBTB8A RBBP5 ZFHX2 ZNF341 SCRT2 PATZ1
ENSR00000275695 -1265 201 SIN3A ZNF2 ZBTB7B GLIS2 ZNF263 SP3 REST ZNF579 ZNF610 ZSCAN16

Genomic Location for KCNK13 Gene

Chromosome:
14
Start:
90,061,765 bp from pter
End:
90,185,857 bp from pter
Size:
124,093 bases
Orientation:
Plus strand

Genomic View for KCNK13 Gene

Genes around KCNK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK13 Gene

Proteins for KCNK13 Gene

  • Protein details for KCNK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB14-KCNKD_HUMAN
    Recommended name:
    Potassium channel subfamily K member 13
    Protein Accession:
    Q9HB14
    Secondary Accessions:
    • B5TJL8
    • Q96E79

    Protein attributes for KCNK13 Gene

    Size:
    408 amino acids
    Molecular mass:
    45391 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The current is enhanced by arachidonic acid and inhibited by halothane.

neXtProt entry for KCNK13 Gene

Post-translational modifications for KCNK13 Gene

  • Glycosylation at posLast=5959 and isoforms=65
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK13 Gene

Domains & Families for KCNK13 Gene

Gene Families for KCNK13 Gene

Suggested Antigen Peptide Sequences for KCNK13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB14

UniProtKB/Swiss-Prot:

KCNKD_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK13: view

Function for KCNK13 Gene

Molecular function for KCNK13 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel displaying weak inward rectification in symmetrical K(+) solution.

Gene Ontology (GO) - Molecular Function for KCNK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS --
genes like me logo Genes that share ontologies with KCNK13: view

Phenotypes for KCNK13 Gene

genes like me logo Genes that share phenotypes with KCNK13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK13

CRISPR Products

miRNA for KCNK13 Gene

miRTarBase miRNAs that target KCNK13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK13 Gene

Localization for KCNK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK13 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK13: view

Pathways & Interactions for KCNK13 Gene

genes like me logo Genes that share pathways with KCNK13: view

Interacting Proteins for KCNK13 Gene

Gene Ontology (GO) - Biological Process for KCNK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK13: view

No data available for SIGNOR curated interactions for KCNK13 Gene

Drugs & Compounds for KCNK13 Gene

(4) Drugs for KCNK13 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, antagonist 2
BL 1249 Pharma Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener 0
DMP 543 Pharma K+ channel blocker and potent ACh release enhancer 0
ML365 Pharma Potent and selective TASK-1 channel blocker 0

(2) Additional Compounds for KCNK13 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK13 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3
genes like me logo Genes that share compounds with KCNK13: view

Transcripts for KCNK13 Gene

mRNA/cDNA for KCNK13 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK13 Gene

Potassium channel, subfamily K, member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK13 Gene

No ASD Table

Relevant External Links for KCNK13 Gene

GeneLoc Exon Structure for
KCNK13
ECgene alternative splicing isoforms for
KCNK13

Expression for KCNK13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK13 Gene

This gene is overexpressed in Testis (x13.3).

Protein differential expression in normal tissues from HIPED for KCNK13 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK13 Gene



Protein tissue co-expression partners for KCNK13 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNK13 Gene:

KCNK13

SOURCE GeneReport for Unigene cluster for KCNK13 Gene:

Hs.510191

Evidence on tissue expression from TISSUES for KCNK13 Gene

  • Nervous system(4.3)
  • Lung(4)
genes like me logo Genes that share expression patterns with KCNK13: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK13 Gene

Orthologs for KCNK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK13 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia KCNK13 34 35
  • 89.05 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk13 34
  • 85.02 (n)
mouse
(Mus musculus)
Mammalia Kcnk13 34 16 35
  • 84.77 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNK13 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK13 35
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK13 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK13 34 35
  • 79.98 (n)
lizard
(Anolis carolinensis)
Reptilia KCNK13 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk13 34
  • 69.69 (n)
zebrafish
(Danio rerio)
Actinopterygii kcnk13a 34 35
  • 67.73 (n)
kcnk13b 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ork1 35
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea twk-12 36
  • 38 (a)
twk-14 35
  • 29 (a)
OneToMany
Species where no ortholog for KCNK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK13 Gene

ENSEMBL:
Gene Tree for KCNK13 (if available)
TreeFam:
Gene Tree for KCNK13 (if available)

Paralogs for KCNK13 Gene

Paralogs for KCNK13 Gene

(1) SIMAP similar genes for KCNK13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNK13: view

Variants for KCNK13 Gene

Sequence variations from dbSNP and Humsavar for KCNK13 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000000373 -- 90,169,672(+) AGATG(C/T)CCCCT intron-variant
rs1000061534 -- 90,126,933(+) AGGTT(A/G)TCAAA intron-variant
rs1000069979 -- 90,143,909(+) AAATT(C/T)CTATT intron-variant
rs1000113598 -- 90,127,291(+) CCATG(C/T)CTGGC intron-variant
rs1000125735 -- 90,151,816(+) TAAGG(A/G)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK13 Gene

Variant ID Type Subtype PubMed ID
esv2667239 CNV deletion 23128226
esv275480 CNV gain+loss 21479260
esv3581384 CNV loss 25503493
esv3635306 CNV gain 21293372
esv3635307 CNV loss 21293372
esv3892575 CNV gain 25118596
nsv1122924 CNV deletion 24896259
nsv1392 CNV deletion 18451855
nsv832854 CNV gain 17160897
nsv85254 CNV insertion 16902084
nsv974360 CNV duplication 23825009

Variation tolerance for KCNK13 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK13 Gene

Disorders for KCNK13 Gene

Relevant External Links for KCNK13

Genetic Association Database (GAD)
KCNK13
Human Genome Epidemiology (HuGE) Navigator
KCNK13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK13

No disorders were found for KCNK13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK13 Gene

Publications for KCNK13 Gene

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PMID: 11060316) Rajan S. … Derst C. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J. … Thomas D. (Br. J. Pharmacol. 2008) 3 4 64
  4. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PMID: 18209473) Theilig F. … Derst C. (Cell. Physiol. Biochem. 2008) 3 22 64
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64

Products for KCNK13 Gene

Sources for KCNK13 Gene

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