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Aliases for KCNK12 Gene

Aliases for KCNK12 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 12 2 3 5
  • Tandem Pore Domain Halothane-Inhibited Potassium Channel 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 12 2 3
  • Potassium Channel, Subfamily K, Member 12 2 3
  • THIK-2 3 4
  • Tandem Pore Domain Potassium Channel THIK-2 3
  • Potassium Channel Subfamily K Member 12 3
  • K2p12.1 3
  • THIK2 3

External Ids for KCNK12 Gene

Previous GeneCards Identifiers for KCNK12 Gene

  • GC02M047763
  • GC02M047916
  • GC02M047722
  • GC02M047659
  • GC02M047747

Summaries for KCNK12 Gene

Entrez Gene Summary for KCNK12 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK12 Gene

KCNK12 (Potassium Two Pore Domain Channel Subfamily K Member 12) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Cardiac conduction. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK13.

UniProtKB/Swiss-Prot for KCNK12 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Tocris Summary for KCNK12 Gene

Gene Wiki entry for KCNK12 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK12 Gene

Genomics for KCNK12 Gene

Regulatory Elements for KCNK12 Gene

Enhancers for KCNK12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F047654 1.2 Ensembl ENCODE 9.5 -83.9 -83933 1.7 ATF1 ZNF133 PTRF ZNF48 RAD21 SCRT2 FOS ZBTB11 USF2 ZEB2 KCNK12 HCG2040054 GTF2A1L GC02P047676
GH02F047297 1.5 FANTOM5 Ensembl ENCODE 3.7 +271.2 271239 4.2 ATF1 ELK1 KLF13 ZNF592 CREB3 MEF2D GLIS1 PBX2 NBN KDM1A LOC101927043 CALM2 EPCAM MIR559 KCNK12 PIR58315 PIR36995
GH02F047563 0.5 FANTOM5 7.5 +7.4 7421 0.2 MAFK HCG2040054 KCNK12 MSH2 PIR54322
GH02F047568 0.5 FANTOM5 3.5 +2.6 2632 0.0 RFX1 ATF2 KCNK12 MSH2 MSH6 FBXO11 PIR54322
GH02F047571 0.9 ENCODE 0.8 -0.3 -298 0.2 MLX ZFP64 SIN3A THRB ZNF48 DNMT3B ZEB1 ZNF143 CREM MIXL1 MSH2 LOC100506235 KCNK12 GC02P047676
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNK12 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001822541 439 1001 CTCF MAZ SP3 RNF2 SP2 REST ZEB2 ZEB1 GATA3 PATZ1

Genomic Location for KCNK12 Gene

Chromosome:
2
Start:
47,516,574 bp from pter
End:
47,570,939 bp from pter
Size:
54,366 bases
Orientation:
Minus strand

Genomic View for KCNK12 Gene

Genes around KCNK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK12 Gene

Proteins for KCNK12 Gene

  • Protein details for KCNK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB15-KCNKC_HUMAN
    Recommended name:
    Potassium channel subfamily K member 12
    Protein Accession:
    Q9HB15

    Protein attributes for KCNK12 Gene

    Size:
    430 amino acids
    Molecular mass:
    46889 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK12 Gene

Post-translational modifications for KCNK12 Gene

  • Glycosylation at Asn 78
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK12 Gene

Domains & Families for KCNK12 Gene

Gene Families for KCNK12 Gene

Suggested Antigen Peptide Sequences for KCNK12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB15

UniProtKB/Swiss-Prot:

KCNKC_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK12: view

Function for KCNK12 Gene

Molecular function for KCNK12 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Gene Ontology (GO) - Molecular Function for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IMP --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0005515 protein binding IPI --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with KCNK12: view

Phenotypes for KCNK12 Gene

genes like me logo Genes that share phenotypes with KCNK12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK12

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK12 Gene

Localization for KCNK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK12 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IDA --
genes like me logo Genes that share ontologies with KCNK12: view

Pathways & Interactions for KCNK12 Gene

genes like me logo Genes that share pathways with KCNK12: view

Interacting Proteins for KCNK12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327611%0d%0a9606.ENSP00000342070%0d%0a
Selected Interacting proteins: ENSP00000327611 Q9HB15-KCNKC_HUMAN for KCNK12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK12: view

No data available for SIGNOR curated interactions for KCNK12 Gene

Drugs & Compounds for KCNK12 Gene

(4) Drugs for KCNK12 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, antagonist 2
BL 1249 Pharma Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener 0
DMP 543 Pharma K+ channel blocker and potent ACh release enhancer 0
ML365 Pharma Potent and selective TASK-1 channel blocker 0

(2) Additional Compounds for KCNK12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK12 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3
genes like me logo Genes that share compounds with KCNK12: view

Transcripts for KCNK12 Gene

mRNA/cDNA for KCNK12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK12 Gene

Potassium channel, subfamily K, member 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK12 Gene

No ASD Table

Relevant External Links for KCNK12 Gene

GeneLoc Exon Structure for
KCNK12
ECgene alternative splicing isoforms for
KCNK12

Expression for KCNK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK12 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK12 Gene

This gene is overexpressed in Nerve - Tibial (x13.5), Brain - Spinal cord (cervical c-1) (x6.5), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for KCNK12 Gene

This gene is overexpressed in Saliva (50.8) and Urine (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK12 Gene



Protein tissue co-expression partners for KCNK12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK12 Gene:

KCNK12

SOURCE GeneReport for Unigene cluster for KCNK12 Gene:

Hs.591586
genes like me logo Genes that share expression patterns with KCNK12: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCNK12 Gene

Orthologs for KCNK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK12 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia KCNK12 34 35
  • 97.25 (n)
cow
(Bos Taurus)
Mammalia KCNK12 34 35
  • 96.67 (n)
mouse
(Mus musculus)
Mammalia Kcnk12 34 16 35
  • 96.2 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk12 34
  • 95.97 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNK12 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNK12 34 35
  • 73.47 (n)
lizard
(Anolis carolinensis)
Reptilia KCNK12 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk12 34
  • 66.33 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559153 34
  • 68.94 (n)
KCNK12 35
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea twk-14 34 35
  • 44.63 (n)
twk-12 36
  • 37 (a)
Species where no ortholog for KCNK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK12 Gene

ENSEMBL:
Gene Tree for KCNK12 (if available)
TreeFam:
Gene Tree for KCNK12 (if available)

Paralogs for KCNK12 Gene

Paralogs for KCNK12 Gene

(1) SIMAP similar genes for KCNK12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK12: view

Variants for KCNK12 Gene

Sequence variations from dbSNP and Humsavar for KCNK12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10184441 -- 47,532,003(+) gatca(C/T)gtcac intron-variant
rs10190337 -- 47,558,831(+) TGTGG(G/T)TGGGG intron-variant
rs10191800 -- 47,543,554(+) AACCC(A/G)TGGGA intron-variant
rs10451620 -- 47,542,895(+) ACACA(A/C/T)TGGCT intron-variant
rs10495945 -- 47,524,100(+) ACCCA(C/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK12 Gene

Variant ID Type Subtype PubMed ID
dgv6848n54 CNV loss 21841781
dgv6849n54 CNV gain 21841781
dgv6850n54 CNV gain+loss 21841781
dgv6851n54 CNV loss 21841781
dgv691e214 CNV loss 21293372
esv2675502 CNV deletion 23128226
esv29460 CNV loss 19812545
esv3590632 CNV gain 21293372
nsv1004828 CNV gain 25217958
nsv1144896 CNV deletion 24896259
nsv2717 CNV insertion 18451855
nsv998314 CNV loss 25217958
nsv999576 CNV gain 25217958

Variation tolerance for KCNK12 Gene

Gene Damage Index Score: 0.37; 8.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK12 Gene

Disorders for KCNK12 Gene

Relevant External Links for KCNK12

Genetic Association Database (GAD)
KCNK12
Human Genome Epidemiology (HuGE) Navigator
KCNK12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK12

No disorders were found for KCNK12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK12 Gene

Publications for KCNK12 Gene

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PMID: 11060316) Rajan S. … Derst C. (J. Biol. Chem. 2001) 2 3 4 64
  2. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea S.A. … Spritz R.A. (J. Invest. Dermatol. 2010) 3 46 64
  3. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PMID: 18209473) Theilig F. … Derst C. (Cell. Physiol. Biochem. 2008) 3 22 64
  4. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KCNK12 Gene

Sources for KCNK12 Gene

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