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Aliases for KCNK12 Gene

Aliases for KCNK12 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 12 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 12 2 3 5
  • Tandem Pore Domain Halothane-Inhibited Potassium Channel 2 3 4
  • Potassium Channel, Subfamily K, Member 12 2 3
  • THIK-2 3 4
  • Tandem Pore Domain Potassium Channel THIK-2 3
  • K2p12.1 3
  • THIK2 3

External Ids for KCNK12 Gene

Previous GeneCards Identifiers for KCNK12 Gene

  • GC02M047763
  • GC02M047916
  • GC02M047722
  • GC02M047659
  • GC02M047747

Summaries for KCNK12 Gene

Entrez Gene Summary for KCNK12 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK12 Gene

KCNK12 (Potassium Two Pore Domain Channel Subfamily K Member 12) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK12 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Tocris Summary for KCNK12 Gene

Gene Wiki entry for KCNK12 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK12 Gene

Genomics for KCNK12 Gene

Regulatory Elements for KCNK12 Gene

Enhancers for KCNK12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNK12 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK12 Gene

47,516,574 bp from pter
47,570,939 bp from pter
54,366 bases
Minus strand

Genomic View for KCNK12 Gene

Genes around KCNK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK12 Gene

Proteins for KCNK12 Gene

  • Protein details for KCNK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 12
    Protein Accession:

    Protein attributes for KCNK12 Gene

    430 amino acids
    Molecular mass:
    46889 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK12 Gene

Proteomics data for KCNK12 Gene at MOPED

Post-translational modifications for KCNK12 Gene

  • Glycosylation at Asn 78
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK12 Gene

Domains & Families for KCNK12 Gene

Gene Families for KCNK12 Gene

Suggested Antigen Peptide Sequences for KCNK12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK12: view

Function for KCNK12 Gene

Molecular function for KCNK12 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Phenotypes for KCNK12 Gene

genes like me logo Genes that share phenotypes with KCNK12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK12 Gene

Localization for KCNK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK12 Gene COMPARTMENTS Subcellular localization image for KCNK12 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for KCNK12 Gene

Pathways & Interactions for KCNK12 Gene

genes like me logo Genes that share pathways with KCNK12: view

Interacting Proteins for KCNK12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327611 for KCNK12 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KCNK12 Gene


No data available for SIGNOR curated interactions for KCNK12 Gene

Drugs & Compounds for KCNK12 Gene

(1) Drugs for KCNK12 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved Pharma Activator, antagonist 1

(5) Additional Compounds for KCNK12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
Cesium chloride
DMP 543
ML 365

(5) Tocris Compounds for KCNK12 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
genes like me logo Genes that share compounds with KCNK12: view

Transcripts for KCNK12 Gene

mRNA/cDNA for KCNK12 Gene

Unigene Clusters for KCNK12 Gene

Potassium channel, subfamily K, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK12 Gene

No ASD Table

Relevant External Links for KCNK12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK12 Gene

mRNA expression in normal human tissues for KCNK12 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK12 Gene

This gene is overexpressed in Nerve - Tibial (x13.5), Brain - Spinal cord (cervical c-1) (x6.5), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for KCNK12 Gene

This gene is overexpressed in Saliva (50.8) and Urine (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK12 Gene

SOURCE GeneReport for Unigene cluster for KCNK12 Gene Hs.591586

genes like me logo Genes that share expression patterns with KCNK12: view

Protein tissue co-expression partners for KCNK12 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KCNK12 Gene

Orthologs for KCNK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK12 35
  • 96.67 (n)
  • 99.53 (a)
KCNK12 36
  • 100 (a)
(Canis familiaris)
Mammalia KCNK12 35
  • 97.25 (n)
  • 98.5 (a)
KCNK12 36
  • 98 (a)
(Mus musculus)
Mammalia Kcnk12 35
  • 96.2 (n)
  • 99.07 (a)
Kcnk12 16
Kcnk12 36
  • 99 (a)
(Pan troglodytes)
Mammalia KCNK12 35
  • 99.69 (n)
  • 100 (a)
KCNK12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnk12 35
  • 95.97 (n)
  • 98.84 (a)
(Monodelphis domestica)
Mammalia KCNK12 36
  • 88 (a)
(Gallus gallus)
Aves KCNK12 35
  • 73.47 (n)
  • 78.34 (a)
KCNK12 36
  • 78 (a)
(Anolis carolinensis)
Reptilia KCNK12 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk12 35
  • 66.33 (n)
  • 77.08 (a)
(Danio rerio)
Actinopterygii LOC559153 35
  • 68.94 (n)
  • 72.22 (a)
KCNK12 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea twk-12 37
  • 37 (a)
twk-14 35
  • 44.63 (n)
  • 37.67 (a)
twk-14 36
  • 29 (a)
Species with no ortholog for KCNK12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK12 Gene

Gene Tree for KCNK12 (if available)
Gene Tree for KCNK12 (if available)

Paralogs for KCNK12 Gene

(1) SIMAP similar genes for KCNK12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK12: view

Variants for KCNK12 Gene

Sequence variations from dbSNP and Humsavar for KCNK12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1922043 -- 47,567,821(-) GAGCT(A/G)TATTC intron-variant
rs1065650 -- 47,568,133(+) AAGCC(A/G)GAACA intron-variant
rs4953503 -- 47,567,287(+) CTTCA(C/T)TGGAT intron-variant
rs2042648 -- 47,570,898(-) GGCTC(C/T)GAAGC upstream-variant-2KB
rs13022465 -- 47,566,383(+) CTCTA(G/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK12 Gene

Variant ID Type Subtype PubMed ID
nsv2717 CNV Insertion 18451855
esv2675502 CNV Deletion 23128226
esv29460 CNV Loss 19812545

Variation tolerance for KCNK12 Gene

Gene Damage Index Score: 0.37; 8.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCNK12 Gene

Disorders for KCNK12 Gene

Relevant External Links for KCNK12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCNK12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK12 Gene

Publications for KCNK12 Gene

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PMID: 11060316) Rajan S. … Derst C. (J. Biol. Chem. 2001) 2 3 4 67
  2. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PMID: 18209473) Theilig F. … Derst C. (Cell. Physiol. Biochem. 2008) 3 23
  3. Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. (PMID: 25148687) Blin S. … Bichet D. (J. Biol. Chem. 2014) 3
  4. Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. (PMID: 24163367) Chatelain F.C. … Lesage F. (J. Biol. Chem. 2013) 3
  5. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea S.A. … Spritz R.A. (J. Invest. Dermatol. 2010) 3

Products for KCNK12 Gene

Sources for KCNK12 Gene