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Aliases for KCNK12 Gene

Aliases for KCNK12 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 12 2 3
  • Tandem Pore Domain Halothane-Inhibited Potassium Channel 2 3 4
  • Potassium Channel, Subfamily K, Member 12 2 3
  • THIK-2 3 4
  • THIK2 3 6
  • Tandem Pore Domain Potassium Channel THIK-2 3
  • Potassium Channel Subfamily K Member 12 3
  • K2p12.1 3

External Ids for KCNK12 Gene

Previous GeneCards Identifiers for KCNK12 Gene

  • GC02M047763
  • GC02M047916
  • GC02M047722
  • GC02M047659
  • GC02M047747

Summaries for KCNK12 Gene

Entrez Gene Summary for KCNK12 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK12 Gene

KCNK12 (Potassium Channel, Two Pore Domain Subfamily K, Member 12) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK12 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Tocris Summary for KCNK12 Gene

Gene Wiki entry for KCNK12 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK12 Gene

Genomics for KCNK12 Gene

Regulatory Elements for KCNK12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK12 Gene

47,516,581 bp from pter
47,570,939 bp from pter
54,359 bases
Minus strand

Genomic View for KCNK12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK12 Gene

Proteins for KCNK12 Gene

  • Protein details for KCNK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 12
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KCNK12 Gene

    430 amino acids
    Molecular mass:
    46889 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK12 Gene

Proteomics data for KCNK12 Gene at MOPED

Post-translational modifications for KCNK12 Gene

  • Glycosylation at Asn78
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK12 Gene

Domains for KCNK12 Gene

Gene Families for KCNK12 Gene

  • KCN :Potassium channels
  • KCNK :Voltage-gated ion channels / Potassium channels, Two-P

Suggested Antigen Peptide Sequences for KCNK12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9HB15
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK12: view

Function for KCNK12 Gene

Molecular function for KCNK12 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Gene Ontology (GO) - Molecular Function for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNK12 Gene

Localization for KCNK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK12 Gene COMPARTMENTS Subcellular localization image for KCNK12 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNK12: view

Pathways for KCNK12 Gene

genes like me logo Genes that share pathways with KCNK12: view

Interacting Proteins for KCNK12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327611 for KCNK12 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with KCNK12: view

Compounds for KCNK12 Gene

(5) Tocris Compounds for KCNK12 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(1) IUPHAR Ligand for KCNK12 Gene

Ligand Type Action Affinity Pubmed IDs
halothane Activator None
genes like me logo Genes that share compounds with KCNK12: view

Transcripts for KCNK12 Gene

mRNA/cDNA for KCNK12 Gene

(35) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK12 Gene

Potassium channel, subfamily K, member 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNK12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK12 Gene

No ASD Table

Relevant External Links for KCNK12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK12 Gene

mRNA expression in normal human tissues for KCNK12 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK12 Gene

This gene is overexpressed in Nerve - Tibial (13.5), Brain - Spinal cord (cervical c-1) (6.5), and Brain - Cerebellar Hemisphere (4.2).

Protein differential expression in normal tissues for KCNK12 Gene

This gene is overexpressed in Saliva (50.8) and Urine (14.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNK12 Gene

SOURCE GeneReport for Unigene cluster for KCNK12 Gene Hs.591586

genes like me logo Genes that share expressions with KCNK12: view

Expression partners for KCNK12 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KCNK12 Gene

Orthologs for KCNK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK12 35
  • 96.67 (n)
  • 99.53 (a)
KCNK12 36
  • 100 (a)
(Canis familiaris)
Mammalia KCNK12 35
  • 97.25 (n)
  • 98.5 (a)
KCNK12 36
  • 98 (a)
(Mus musculus)
Mammalia Kcnk12 35
  • 96.2 (n)
  • 99.07 (a)
Kcnk12 16
Kcnk12 36
  • 99 (a)
(Pan troglodytes)
Mammalia KCNK12 35
  • 99.69 (n)
  • 100 (a)
KCNK12 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnk12 35
  • 95.97 (n)
  • 98.84 (a)
(Monodelphis domestica)
Mammalia KCNK12 36
  • 88 (a)
(Gallus gallus)
Aves KCNK12 35
  • 73.47 (n)
  • 78.34 (a)
KCNK12 36
  • 78 (a)
(Anolis carolinensis)
Reptilia KCNK12 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk12 35
  • 66.33 (n)
  • 77.08 (a)
(Danio rerio)
Actinopterygii LOC559153 35
  • 68.94 (n)
  • 72.22 (a)
KCNK12 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea twk-12 37
  • 37 (a)
twk-14 35
  • 44.63 (n)
  • 37.67 (a)
twk-14 36
  • 29 (a)
Species with no ortholog for KCNK12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK12 Gene

Gene Tree for KCNK12 (if available)
Gene Tree for KCNK12 (if available)

Paralogs for KCNK12 Gene

Selected SIMAP similar genes for KCNK12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK12: view

Variants for KCNK12 Gene

Sequence variations from dbSNP and Humsavar for KCNK12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs748780 -- 47,536,756(+) attta(C/T)ggagg intron-variant
rs1065650 -- 47,568,133(+) AAGCC(A/G)GAACA intron-variant
rs1237242 -- 47,550,475(-) aaccc(A/G)ggagg intron-variant
rs1425610 -- 47,560,570(-) ATCCA(C/G)GGCTC intron-variant
rs1425613 -- 47,566,078(-) TTTGT(A/G)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK12 Gene

Variant ID Type Subtype PubMed ID
nsv2717 CNV Insertion 18451855
esv2675502 CNV Deletion 23128226
esv29460 CNV Loss 19812545

Relevant External Links for KCNK12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK12 Gene

Disorders for KCNK12 Gene

Relevant External Links for KCNK12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KCNK12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCNK12 Gene

Publications for KCNK12 Gene

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PMID: 11060316) Rajan S. … Derst C. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt D.R. … Palotie A. (Hum. Mol. Genet. 2008) 3 48
  4. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea S.A. … Spritz R.A. (J. Invest. Dermatol. 2010) 3 48
  5. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PMID: 18209473) Theilig F. … Derst C. (Cell. Physiol. Biochem. 2008) 3 23

Products for KCNK12 Gene

Sources for KCNK12 Gene

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