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KCNK10 Gene

protein-coding   GIFtS: 58
GCID: GC14M090241

Potassium Channel, Subfamily K, Member 10

  See KCNK10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Channel, Subfamily K, Member 101 2     K2p10.12
TREK22 3 5     TREK-22
Outward Rectifying Potassium Channel Protein TREK-22 3     Potassium Channel Subfamily K Member 102
TREK-2 K(+) Channel Subunit2 3     Potassium Channel TREK-22
2P Domain Potassium Channel TREK22     TWIK-Related K+ Channel 22

External Ids:    HGNC: 62731   Entrez Gene: 542072   Ensembl: ENSG000001004337   OMIM: 6058735   UniProtKB: P577893   

Export aliases for KCNK10 gene to outside databases

Previous GC identifers: GC14M086156 GC14M082468 GC14M086641 GC14M087720 GC14M088648 GC14M068816 GC14M088649 GC14M088927 GC14M089528 GC14M089829


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNK10 Gene:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P
domains. This channel is an open rectifier which primarily passes outward current under physiological K+
concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching,
intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding
different isoforms have been identified for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for KCNK10 Gene:
KCNK10 (potassium channel, subfamily K, member 10) is a protein-coding gene. Diseases associated with KCNK10 include dentin sensitivity. GO annotations related to this gene include voltage-gated ion channel activity and potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids

Gene Wiki entry for KCNK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK10 gene promoter:
         POU3F1   c-Myb   Cart-1   Meis-1a   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNK10 promoter sequence
   Search Chromatin IP Primers for KCNK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.3   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q31

KCNK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M090241:  view genomic region     (about GC identifiers)

Start:
88,646,452 bp from pter      End:
88,793,256 bp from pter
Size:
146,805 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 10  
Size: 538 amino acids; 59765 Da
1 PDB 3D structure from and Proteopedia for KCNK10:
4BW5 (3D)    
Secondary accessions: B2R8T4 B2RCT3 B5TJL4 Q6B014 Q8TDK7 Q8TDK8 Q9HB59
Alternative splicing: 3 isoforms:  P57789-1   P57789-4   P57789-3   

Explore the universe of human proteins at neXtProt for KCNK10: NX_P57789

Explore proteomics data for KCNK10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn144, Asn147, Asn148
  • Modification sites at PhosphoSitePlus

  • See KCNK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_066984.1  NP_612190.1  NP_612191.1  

    ENSEMBL proteins: 
     ENSP00000343104   ENSP00000310568   ENSP00000312811   ENSP00000452587  
    Reactome Protein details: P57789

    KCNK10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KCNK10

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P10.1
    Two-P potassium channels

    3 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR003976 2pore_dom_K_chnl_TREK
     IPR013099 2pore_dom_K_chnl_dom

    Graphical View of Domain Structure for InterPro Entry P57789

    ProtoNet protein and cluster: P57789

    3 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB003976 Trek K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Find genes that share domains with KCNK10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNKA_HUMAN, P57789
    Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
    K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005267potassium channel activity IEA--
         
    Find genes that share ontologies with KCNK10           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnk10):
     nervous system 

    Find genes that share phenotypes with KCNK10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnk10tm1Fles for KCNK10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNK10
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    SwitchGear 3'UTR luciferase reporter plasmidKCNK10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNKA_HUMAN, P57789: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KCNK10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNK10 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Tandem pore domain potassium channels0.00
    Potassium transporters outward current0.41
    TWIK related potassium channel (TREK)0.00
    2Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41


    Find genes that share SuperPaths with KCNK10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNK10 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    1 Reactome Pathway for KCNK10
        TWIK related potassium channel (TREK)


    1 Kegg Pathway  (Kegg details for KCNK10):
        Gastric acid secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNK10
    Interactions:

        Search GeneGlobe Interaction Network for KCNK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for KCNK10 (P577892 ENSP000003105684) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNK2ENSP000003940334STRING: ENSP00000394033
    KCNK4ENSP000003780334STRING: ENSP00000378033
    PPP1CAENSP000003260314STRING: ENSP00000326031
    SORT1ENSP000002566374STRING: ENSP00000256637
    MAPK11ENSP000003336854STRING: ENSP00000333685
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10880510
    GO:0007165signal transduction NAS10880510
    GO:0007268synaptic transmission TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNK10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    3 IUPHAR Ligands for KCNK10 (K2P10.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    halothane
    ActivatorNone--
    arachidonic acid
    ActivatorNone--
    riluzole
    ActivatorNone--

    3 Novoseek inferred chemical compound relationships for KCNK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 66.5 6 15351740 (1), 18845607 (1), 17689202 (1), 16075240 (1)
    potassium 43.3 5 11897838 (2), 15076761 (1), 16007342 (1), 17689202 (1)
    halothane 40 2 10880510 (1), 16075240 (1)



    Find genes that share compounds with KCNK10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNK10 gene (3 alternative transcripts): 
    NM_021161.4  NM_138317.2  NM_138318.2  

    Unigene Cluster for KCNK10:

    Potassium channel, subfamily K, member 10
    Hs.560255  [show with all ESTs]
    Unigene Representative Sequence: NM_138317
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340700(uc001xwm.3 uc001xwn.3 uc001xwo.3) ENST00000312350
    ENST00000319231 ENST00000556282
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KCNK10
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    Additional mRNA sequence: 

    AF279890.1 AF385399.1 AF385400.1 AK125389.1 AK290518.1 AK313499.1 AK315263.1 BC075021.2 
    BC075022.2 EU978938.1 EU978939.1 EU978940.1 EU978941.1 U79244.1 

    6 DOTS entries:

    DT.40290075  DT.40225695  DT.97783749  DT.97771737  DT.40273764  DT.100060972 

    Selected AceView cDNA sequences (see all 32):

    NM_138318 CD636362 NM_021161 AF385400 NM_138317 AI823437 BC075022 CD636360 
    BC075021 BF224089 AI863493 AF385399 AI073392 BF593106 AF279890 BX114100 
    AI693366 AW015693 Z38660 BI669964 AL117586 AI299142 AI694802 CD636363 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNK10 Expression
    About this image


    KCNK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebellum
    KCNK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNK10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.560255

    UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
    Tissue specificity: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and
    small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas,
    whereas isoform c is abundantly expressed in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNK10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk101 , 5 potassium channel, subfamily K, member 101, 5 89.21(n)1
    96.55(a)1
      12 (49.86 cM)5
    722581  NM_029911.41  NP_084187.21 
     984339945 
    chicken
    (Gallus gallus)
    Aves KCNK101 potassium channel, subfamily K, member 10 81.78(n)
    90.11(a)
      428902  XM_004941854.1  XP_004941911.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK106
    potassium channel, subfamily K, member 10
    84(a)
    1 ↔ 1
    1(13794726-13887570)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnk101 potassium channel, subfamily K, member 10 73.31(n)
    80.26(a)
      100497885  XM_002933194.2  XP_002933240.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnk10b1 potassium channel, subfamily K, member 10b 69.56(n)
    75.59(a)
      565629  NM_001161399.1  NP_001154871.1 


    ENSEMBL Gene Tree for KCNK10 (if available)
    TreeFam Gene Tree for KCNK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNK10 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  
    KCNK72  KCNK172  KCNK42  KCNK132  KCNK12  
    5 SIMAP similar genes for KCNK10 using alignment to 3 protein entries:     KCNKA_HUMAN (see all proteins):
    KCNK2    KCNK4    KCNK16    KCNK1    KCNK6

    Find genes that share paralogs with KCNK10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNK10 (see all 3396)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609951941,2
    C--69684402(+) AAAAA-/A/AA  
            
    GAAAA
    3 -- int12NA 4
    rs556825621,2
    C--88646102(+) CCTGGC/TGCGAT 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1872184871,2
    --88646104(+) TGGCGC/TGATGT 3 -- ds50010--------
    rs93238231,2
    C,F,H--88646126(+) GTTTCA/CCCAAG 3 -- ds500111Minor allele frequency- C:0.12NS EA NA WA 1312
    rs1423947241,2
    --88646163(+) GTCCCA/GGCAAT 3 -- ds50010--------
    rs1917754441,2
    --88646220(+) AGCAAA/CAATTC 3 -- ds50010--------
    rs801055691,2
    C,F--88646290(+) AGTGAG/CTCTCC 3 -- ds50014Minor allele frequency- C:0.08CSA WA NA EA 360
    rs1465858221,2
    --88646337(+) AAGAAA/GCACCT 3 -- ds50010--------
    rs1144150311,2
    C,F--88646595(+) ATGAAA/CTCTCC 3 -- ut311Minor allele frequency- C:0.05WA 118
    rs617412731,2
    C,F--88646612(+) CCACAT/CTATTT 3 -- ut312Minor allele frequency- C:0.05NS WA 196

    HapMap Linkage Disequilibrium report for KCNK10 (88646452 - 88793256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KCNK10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748991CNV Deletion23290073
    nsv84705CNV Insertion16902084
    esv274199CNV Insertion20981092
    nsv85763CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605873    OMIM disorders: --

    1 disease for KCNK10:    
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    dentin sensitivity

    1 disease from the University of Copenhagen DISEASES database for KCNK10:
    Dentin sensitivity

    Find genes that share disorders with KCNK10           About GenesLikeMe

    Genetic Association Database (GAD): KCNK10

    Export disorders for KCNK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNK10 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with KCNK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. (PubMed id 10880510)1, 2, 3, 9 Lesage F.... Lazdunski M. (J. Biol. Chem. 2000)
    2. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PubMed id 11897838)1, 2, 9 Gu W.... Daut J. (J. Physiol. (Lond.) 2002)
    3. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1, 2 Gierten J....Thomas D. (Br. J. Pharmacol. 2008)
    4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
    5. Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PubMed id 17689202)1, 9 Huang D. and Yu B. (Med. Hypotheses 2008)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels. (PubMed id 21669980)1 Staudacher K....Thomas D. (J. Physiol. (Lond.) 2011)
    8. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (Biol Psychol 2011)
    9. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (Chem. Biol. 2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54207 HGNC: 6273 AceView: KCNK10 Ensembl:ENSG00000100433 euGenes: HUgn54207
    ECgene: KCNK10 Kegg: 54207 H-InvDB: KCNK10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNK10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNK10 gene:
    Search GeneIP for patents involving KCNK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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