KCNK10 Gene
protein-coding GIFtS: 55
GCID: GC14M089528
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|
potassium channel, subfamily K, member 10
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Aliases
for KCNK10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Channel, Subfamily K, Member 101 2 | | TREK-2 K(+) Channel Subunit2 3 | | TREK21 2 3 5 | | 2P Domain Potassium Channel TREK22 | | K2p10.11 2 | | Potassium Channel Subfamily K Member 102 | | TREK-21 2 | | Potassium Channel TREK-22 | | Outward Rectifying Potassium Channel Protein TREK-22 3 | | TWIK-Related K+ Channel 22 |
Export aliases for KCNK10 gene to outside databasesPrevious GC identifers: GC14M086156 GC14M082468 GC14M086641 GC14M087720 GC14M088648 GC14M068816 GC14M088649 GC14M088927 |
Summaries
for KCNK10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNK10:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming Pdomains. This channel is an open rectifier which primarily passes outward current under physiological K+concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching,intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids
Gene Wiki entry for KCNK10
|
Genomic Views
for KCNK10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNK10 gene promoter:
POU3F1 c-Myb Cart-1 Meis-1a Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNK10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q31.3 Ensembl cytogenetic band: 14q31.3 HGNC cytogenetic band: 14q31KCNK10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M089528: view genomic region
(about GC identifiers)
Start:
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88,646,452 bp from pter |
End:
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88,793,256 bp from pter |
Size:
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146,805 bases |
Orientation:
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minus strand |
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Proteins
for KCNK10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789 (See
protein sequence)Recommended Name: Potassium channel subfamily K member 10 Size: 538 amino acids; 59765 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R8T4 B2RCT3 B5TJL4 Q6B014 Q8TDK7 Q8TDK8 Q9HB59Alternative splicing: 3 isoforms: P57789-1 P57789-4 P57789-3 Explore the universe of human proteins at neXtProt for KCNK10: NX_P57789
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57789
KCNK10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_066984.1 NP_612190.1 NP_612191.1
ENSEMBL proteins: ENSP00000343104 ENSP00000310568 ENSP00000312811 ENSP00000452587 Reactome Protein details: P57789
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KCNK10 for ontologies About GeneDecksing
KCNK10 Antibody Products:
Assay Products for KCNK10: |
Protein
Domains /
Families
for KCNK10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNK10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57789ProtoNet protein and cluster: P57789 3 Blocks protein families: IPB003280 Two pore domain K+ channel signature IPB003976 Trek K+ channel signature IPB013099 Ion transport 2
UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family |
Function
for KCNK10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+)currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK10 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK10 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005267 | potassium channel activity |
IEA | -- |
KCNK10 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Kcnk10tm1Fles for KCNK10
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Kcnk10):
KCNK10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNK10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | | | 4 | Potassium Channels | | | 5 | Hepatic ABC Transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KCNK10
5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK10 (see all 13)
4 
Reactome Pathways for KCNK10
1 
Kegg Pathway (Kegg details for KCNK10):
KCNK10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK10
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for KCNK10 (P577892 ENSP000003105684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
KCNK10 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNK10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNK10 for compounds About GeneDecksing
 Compounds for KCNK10 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| YS-035 hydrochloride | Inhibits K+ outward/pacemaker current | [33978-72-2] | | DMP 543 | K+ channel blocker and potent ACh release enhancer | [160588-45-4] |
3 Novoseek chemical compound relationships for KCNK10 gene About this table
Search CenterWatch for drugs/clinical trials and news about KCNK10 / KCNKA
|
Transcripts
for KCNK10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNK10 gene (3 alternative transcripts): NM_021161.4 NM_138317.2 NM_138318.2 Unigene Cluster for KCNK10: Potassium channel, subfamily K, member 10 Hs.560255 [show with all ESTs]Unigene Representative Sequence: NM_1383174 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340700(uc001xwm.3 uc001xwn.3 uc001xwo.3) ENST00000312350
ENST00000319231 ENST00000556282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK10 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNK10 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): KCNK10 (NM_138318) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNK10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK10 |
Additional cDNA sequence: AF279890.1 AF385399.1 AF385400.1 AK125389.1 AK290518.1 AK313499.1 AK315263.1 BC075021.2 BC075022.2 EU978938.1 EU978939.1 EU978940.1 EU978941.1 U79244.1 6 DOTS entries: DT.40290075 DT.40225695 DT.97783749 DT.97771737 DT.40273764 DT.100060972 24/32 AceView cDNA sequences (see all 32): BF224089 NM_021161 AF385400 NM_138317 AI823437 BC075021 BC075022 CD636362 CD636360 NM_138318 AF385399 BX114100 BI669964 AI863493 BF593106 AF279890 AI073392 AI693366 AI694802 AI299142 Z38660 AL117586 AW015693 CD636363
GeneLoc Exon Structure
|
Expression
for KCNK10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KCNK10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNK10
SOURCE GeneReport for Unigene cluster: Hs.560255
UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789Tissue specificity: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and smallintestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoformc is abundantly expressed in brain
SABiosciences Custom PCR Arrays for KCNK10
Primer
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Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK10 |
Orthologs
for KCNK10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNK10 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for KCNK10 (if available)
TreeFam Gene Tree for KCNK10 (if available) |
Paralogs
for KCNK10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNK10 gene
- KCNK152 KCNK52 KCNK162 KCNK32 KCNK122 KCNK92 KCNK62 KCNK22
- KCNK182 KCNK172 KCNK72 KCNK42 KCNK132 KCNK12
5 SIMAP similar genes for KCNK10 using alignment to 3 protein entries: KCNKA_HUMAN (see all proteins):KCNK4 KCNK2 KCNK16 KCNK1 KCNK6
KCNK10 for paralogs About GeneDecksing
|
Genomic Variants
for KCNK10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNK10 (88646452 - 88793256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNK10
1 CNV: 5764 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNK10 |
|
Disorders
/ Diseases
for KCNK10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNK10 for disorders About GeneDecksing
OMIM gene information: 605873
OMIM disorders: --
4  diseases for KCNK10: About MalaCardsdentin sensitivity brain ischemia ischemia memory impairment
1 disease from the University of Copenhagen DISEASES database for KCNK10:Dentin sensitivity Export disorders for KCNK10 gene to outside databases
|
Publications
for KCNK10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNK10 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with KCNK10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. (PubMed id 10880510)1, 2, 3, 9 Lesage F.... Lazdunski M. (2000)
- Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PubMed id 11897838)1, 2, 9 Gu W.... Daut J. (2002)
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1, 2 Gierten J....Thomas D. (2008)
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
- Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PubMed id 17689202)1, 9 Huang D. and Yu B. (2008)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Alternative splicing determines mRNA translation initi ation and function of human K(2P)10.1 K+ channels. (PubMed id 21669980)1 Staudacher K....Thomas D. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
|
External Searches for KCNK10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNK10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNK10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNK10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNK10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNK10 gene:
Search GeneIP for patents involving KCNK10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNK10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK10 |
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