Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK10 Gene

Aliases for KCNK10 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 10 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 10 2 3 5
  • Outward Rectifying Potassium Channel Protein TREK-2 3 4
  • Potassium Channel, Subfamily K, Member 10 2 3
  • TREK-2 K(+) Channel Subunit 3 4
  • TREK2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 97 3
  • 2P Domain Potassium Channel TREK2 3
  • TWIK-Related K+ Channel 2 3
  • Potassium Channel TREK-2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 97 2
  • K2p10.1 3
  • PPP1R97 3
  • TREK-2 3

External Ids for KCNK10 Gene

Previous GeneCards Identifiers for KCNK10 Gene

  • GC14M086156
  • GC14M082468
  • GC14M086641
  • GC14M087720
  • GC14M088648
  • GC14M068816
  • GC14M088649
  • GC14M088927
  • GC14M089528
  • GC14M089829
  • GC14M090241

Summaries for KCNK10 Gene

Entrez Gene Summary for KCNK10 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK10 Gene

KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include dentin sensitivity. Among its related pathways are Salivary secretion and Activation of cAMP-Dependent PKA. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK10 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Tocris Summary for KCNK10 Gene

Gene Wiki entry for KCNK10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK10 Gene

Genomics for KCNK10 Gene

Regulatory Elements for KCNK10 Gene

Enhancers for KCNK10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNK10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNK10 Gene

Chromosome:
14
Start:
88,180,103 bp from pter
End:
88,326,912 bp from pter
Size:
146,810 bases
Orientation:
Minus strand

Genomic View for KCNK10 Gene

Genes around KCNK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK10 Gene

Proteins for KCNK10 Gene

  • Protein details for KCNK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57789-KCNKA_HUMAN
    Recommended name:
    Potassium channel subfamily K member 10
    Protein Accession:
    P57789
    Secondary Accessions:
    • B2R8T4
    • B2RCT3
    • B5TJL4
    • Q6B014
    • Q8TDK7
    • Q8TDK8
    • Q9HB59

    Protein attributes for KCNK10 Gene

    Size:
    538 amino acids
    Molecular mass:
    59765 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KCNK10 Gene

    Alternative splice isoforms for KCNK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK10 Gene

Proteomics data for KCNK10 Gene at MOPED

Post-translational modifications for KCNK10 Gene

  • Glycosylation at Asn 144, Asn 147, and Asn 148
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK10 Gene

No data available for DME Specific Peptides for KCNK10 Gene

Domains & Families for KCNK10 Gene

Graphical View of Domain Structure for InterPro Entry

P57789

UniProtKB/Swiss-Prot:

KCNKA_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK10: view

Function for KCNK10 Gene

Molecular function for KCNK10 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Gene Ontology (GO) - Molecular Function for KCNK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IEA,TAS 10880510
genes like me logo Genes that share ontologies with KCNK10: view
genes like me logo Genes that share phenotypes with KCNK10: view

Animal Models for KCNK10 Gene

MGI Knock Outs for KCNK10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK10 Gene

Localization for KCNK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNK10 Gene COMPARTMENTS Subcellular localization image for KCNK10 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KCNK10 Gene

Pathways & Interactions for KCNK10 Gene

genes like me logo Genes that share pathways with KCNK10: view

Interacting Proteins for KCNK10 Gene

Gene Ontology (GO) - Biological Process for KCNK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10880510
GO:0007613 memory IEA --
genes like me logo Genes that share ontologies with KCNK10: view

No data available for SIGNOR curated interactions for KCNK10 Gene

Drugs & Compounds for KCNK10 Gene

(4) Drugs for KCNK10 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved Pharma Activator, antagonist 1
Riluzole Approved, Investigational Pharma Activator, blocker Sodium channel protein inhibitor 60
arachidonic acid Experimental Nutra Activator 27

(5) Additional Compounds for KCNK10 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BL 1249
18200-13-0
Cesium chloride
7647-17-8
DMP 543
160588-45-4
ML 365
947914-18-3
PK-THPP
1332454-07-5

(5) Tocris Compounds for KCNK10 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
genes like me logo Genes that share compounds with KCNK10: view

Transcripts for KCNK10 Gene

Unigene Clusters for KCNK10 Gene

Potassium channel, subfamily K, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK10 Gene

No ASD Table

Relevant External Links for KCNK10 Gene

GeneLoc Exon Structure for
KCNK10
ECgene alternative splicing isoforms for
KCNK10

Expression for KCNK10 Gene

mRNA expression in normal human tissues for KCNK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK10 Gene

This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Putamen (basal ganglia) (x4.9), Brain - Hippocampus (x4.6), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for KCNK10 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK10 Gene



SOURCE GeneReport for Unigene cluster for KCNK10 Gene Hs.560255

mRNA Expression by UniProt/SwissProt for KCNK10 Gene

P57789-KCNKA_HUMAN
Tissue specificity: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
genes like me logo Genes that share expression patterns with KCNK10: view

Protein tissue co-expression partners for KCNK10 Gene

Primer Products

In Situ Assay Products

Orthologs for KCNK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KCNK10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNK10 35
  • 87.21 (n)
  • 88.64 (a)
KCNK10 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK10 35
  • 92.3 (n)
  • 95.72 (a)
KCNK10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk10 35
  • 89.21 (n)
  • 96.55 (a)
Kcnk10 16
Kcnk10 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNK10 35
  • 99.08 (n)
  • 99.08 (a)
KCNK10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnk10 35
  • 89.76 (n)
  • 96.83 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNK10 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves KCNK10 35
  • 81.78 (n)
  • 90.11 (a)
KCNK10 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK10 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk10 35
  • 73.31 (n)
  • 80.26 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnk10b 35
  • 69.56 (n)
  • 75.59 (a)
kcnk10a 36
  • 63 (a)
OneToMany
kcnk10b 36
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOK1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
CSA.6929 36
  • 33 (a)
ManyToMany
Species with no ortholog for KCNK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK10 Gene

ENSEMBL:
Gene Tree for KCNK10 (if available)
TreeFam:
Gene Tree for KCNK10 (if available)

Paralogs for KCNK10 Gene

(5) SIMAP similar genes for KCNK10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK10: view

Variants for KCNK10 Gene

Sequence variations from dbSNP and Humsavar for KCNK10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17762463 - 88,185,618(+) CTCAG(C/T)GTGCT reference, missense
rs398263 - 88,192,395(+) GGTCT(G/T)ACTCA reference, missense
rs1288320 -- 88,272,902(+) AAGAA(A/G)GGAGG intron-variant, upstream-variant-2KB
rs1288321 -- 88,267,347(+) TTAAG(A/T)TGGAT intron-variant
rs1288322 -- 88,267,572(+) tcacc(A/G)tgctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK10 Gene

Variant ID Type Subtype PubMed ID
nsv85763 CNV Loss 16902084
esv274199 CNV Insertion 20981092
esv2748991 CNV Deletion 23290073
nsv84705 CNV Insertion 16902084

Variation tolerance for KCNK10 Gene

Residual Variation Intolerance Score: 5.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK10 Gene

HapMap Linkage Disequilibrium report
KCNK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK10 Gene

Disorders for KCNK10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCNK10

Genetic Association Database (GAD)
KCNK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK10
genes like me logo Genes that share disorders with KCNK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK10 Gene

Publications for KCNK10 Gene

  1. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. (PMID: 10880510) Lesage F. … Lazdunski M. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PMID: 17689202) Huang D. … Yu B. (Med. Hypotheses 2008) 3 23
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3
  4. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PMID: 11897838) Gu W. … Daut J. (J. Physiol. (Lond.) 2002) 3 23
  5. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. (PMID: 25766236) Dong Y.Y. … Carpenter E.P. (Science 2015) 3

Products for KCNK10 Gene

Sources for KCNK10 Gene

Content