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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNK10 Gene

protein-coding   GIFtS: 57
GCID: GC14M089829

Potassium Channel, Subfamily K, Member 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 101 2     K2p10.12
TREK22 3 5     TREK-22
Outward Rectifying Potassium Channel Protein TREK-22 3     Potassium Channel Subfamily K Member 102
TREK-2 K(+) Channel Subunit2 3     Potassium Channel TREK-22
2P Domain Potassium Channel TREK22     TWIK-Related K+ Channel 22

External Ids:    HGNC: 62731   Entrez Gene: 542072   Ensembl: ENSG000001004337   OMIM: 6058735   UniProtKB: P577893   

Export aliases for KCNK10 gene to outside databases

Previous GC identifers: GC14M086156 GC14M082468 GC14M086641 GC14M087720 GC14M088648 GC14M068816 GC14M088649 GC14M088927 GC14M089528


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK10 Gene:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P
domains. This channel is an open rectifier which primarily passes outward current under physiological K+
concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching,
intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding
different isoforms have been identified for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for KCNK10 Gene: 
KCNK10 (potassium channel, subfamily K, member 10) is a protein-coding gene. Diseases associated with KCNK10 include dentin sensitivity, and brain ischemia, and among its related super-pathways are Voltage gated Potassium channels and Melatonin Signaling. GO annotations related to this gene include voltage-gated ion channel activity and potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids

Gene Wiki entry for KCNK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNK10 gene promoter:
         POU3F1   c-Myb   Cart-1   Meis-1a   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNK10 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.3   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q31

KCNK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M089829:  view genomic region     (about GC identifiers)

Start:
88,646,452 bp from pter      End:
88,793,256 bp from pter
Size:
146,805 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 10  
Size: 538 amino acids; 59765 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R8T4 B2RCT3 B5TJL4 Q6B014 Q8TDK7 Q8TDK8 Q9HB59
Alternative splicing: 3 isoforms:  P57789-1   P57789-4   P57789-3   

Explore the universe of human proteins at neXtProt for KCNK10: NX_P57789

Explore proteomics data for KCNK10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57789

  • KCNK10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNK10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_066984.1  NP_612190.1  NP_612191.1  

    ENSEMBL proteins: 
     ENSP00000343104   ENSP00000310568   ENSP00000312811   ENSP00000452587  
    Reactome Protein details: P57789
    Human Recombinant Protein Products for KCNK10: 
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    Cloud-Clone Corp. Proteins for KCNK10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    KCNK10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P10.1 
    Two-P potassium channels

    3 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR003976 2pore_dom_K_chnl_TREK
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry P57789

    ProtoNet protein and cluster: P57789

    3 Blocks protein domains:
    IPB003280 Two pore domain K+ channel signature
    IPB003976 Trek K+ channel signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    KCNK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNKA_HUMAN, P57789
    Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier
    K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005267potassium channel activity IEA--
         
    KCNK10 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnk10):
     nervous system 

    KCNK10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcnk10tm1Fles for KCNK10

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    SwitchGear 3'UTR luciferase reporter plasmidKCNK10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNK10 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    2Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNK10
        Potassium transporters- outward current

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK10 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling

    4        Reactome Pathways for KCNK10
        Potassium Channels
    Neuronal System
    TWIK related potassium channel (TREK)
    Tandem pore domain potassium channels


    1         Kegg Pathway  (Kegg details for KCNK10):
        Gastric acid secretion


    KCNK10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNK10

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KCNK10 (P577892 ENSP000003105684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNK2ENSP000003940334STRING: ENSP00000394033
    KCNK4ENSP000003780334STRING: ENSP00000378033
    PPP1CAENSP000003260314STRING: ENSP00000326031
    --xp_1380632MINT-4050521
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10880510
    GO:0007165signal transduction NAS10880510
    GO:0007268synaptic transmission TAS--

    KCNK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNK10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNK10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    3 IUPHAR Ligands for KCNK10 (K2P10.1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    halothane
    ActivatorNone--
    arachidonic acid
    ActivatorNone--
    riluzole
    ActivatorNone--

    3 Novoseek inferred chemical compound relationships for KCNK10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 66.5 6 15351740 (1), 18845607 (1), 17689202 (1), 16075240 (1)
    potassium 43.3 5 11897838 (2), 15076761 (1), 16007342 (1), 17689202 (1)
    halothane 40 2 10880510 (1), 16075240 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNK10 / KCNKA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNK10 gene (3 alternative transcripts): 
    NM_021161.4  NM_138317.2  NM_138318.2  

    Unigene Cluster for KCNK10:

    Potassium channel, subfamily K, member 10
    Hs.560255  [show with all ESTs]
    Unigene Representative Sequence: NM_138317
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340700(uc001xwm.3 uc001xwn.3 uc001xwo.3) ENST00000312350
    ENST00000319231 ENST00000556282
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    Additional mRNA sequence: 

    AF279890.1 AF385399.1 AF385400.1 AK125389.1 AK290518.1 AK313499.1 AK315263.1 BC075021.2 
    BC075022.2 EU978938.1 EU978939.1 EU978940.1 EU978941.1 U79244.1 

    6 DOTS entries:

    DT.40290075  DT.40225695  DT.97783749  DT.97771737  DT.40273764  DT.100060972 

    24/32 AceView cDNA sequences (see all 32):

    CD636362 NM_138317 BC075022 BC075021 AI823437 NM_138318 AF385400 BF224089 
    NM_021161 CD636360 AF279890 AL117586 BI669964 BF593106 AI073392 AF385399 
    AI693366 Z38660 AW015693 AI299142 BX114100 AI863493 AI694802 BX281300 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNK10 expression in normal human tissues (normalized intensities)      KCNK10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNK10 Expression
    About this image


    KCNK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             cerebellum   

    See KCNK10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNK10

    SOURCE GeneReport for Unigene cluster: Hs.560255

    UniProtKB/Swiss-Prot: KCNKA_HUMAN, P57789
    Tissue specificity: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and
    small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas,
    whereas isoform c is abundantly expressed in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNK10 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk101 , 5 potassium channel, subfamily K, member 101, 5 89.21(n)1
    96.55(a)1
      12 (49.86 cM)5
    722581  NM_029911.41  NP_084187.21 
     984339945 
    chicken
    (Gallus gallus)
    Aves KCNK101 potassium channel, subfamily K, member 10 81.31(n)
    89.98(a)
      428902  XM_426457.2  XP_426457.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK106
    potassium channel, subfamily K, member 10
    84(a)
    1 ↔ 1
    1(13794726-13887570)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnk10b1 potassium channel, subfamily K, member 10b 66.67(n)
    70.23(a)
      565629  NM_001161399.1  NP_001154871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ork16
    Open rectifier K[+] channel 1
    8(a)
    1 → many
    X(10772087-10784957)


    ENSEMBL Gene Tree for KCNK10 (if available)
    TreeFam Gene Tree for KCNK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNK10 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  
    KCNK72  KCNK172  KCNK42  KCNK132  KCNK12  
    5 SIMAP similar genes for KCNK10 using alignment to 3 protein entries:     KCNKA_HUMAN (see all proteins):
    KCNK4    KCNK2    KCNK16    KCNK1    KCNK6

    KCNK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3396 SNPs in KCNK10 are shown (see all 3396)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609951941,2
    C--69684402(+) AAAAA-/A/AA  
            
    GAAAA
    3 -- int12NA 4
    rs556825621,2
    C--88646102(+) CCTGGC/TGCGAT 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1872184871,2
    --88646104(+) TGGCGC/TGATGT 3 -- ds50010--------
    rs93238231,2
    C,F,H--88646126(+) GTTTCA/CCCAAG 3 -- ds500111Minor allele frequency- C:0.12NS EA NA WA 1312
    rs1423947241,2
    --88646163(+) GTCCCA/GGCAAT 3 -- ds50010--------
    rs1917754441,2
    --88646220(+) AGCAAA/CAATTC 3 -- ds50010--------
    rs801055691,2
    C,F--88646290(+) AGTGAG/CTCTCC 3 -- ds50014Minor allele frequency- C:0.08CSA WA NA EA 360
    rs1465858221,2
    --88646337(+) AAGAAA/GCACCT 3 -- ds50010--------
    rs1144150311,2
    C,F--88646595(+) ATGAAA/CTCTCC 3 -- ut311Minor allele frequency- C:0.05WA 118
    rs617412731,2
    C,F--88646612(+) CCACAT/CTATTT 3 -- ut312Minor allele frequency- C:0.05NS WA 196

    HapMap Linkage Disequilibrium report for KCNK10 (88646452 - 88793256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KCNK10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748991CNV Deletion23290073
    nsv84705CNV Insertion16902084
    esv274199CNV Insertion20981092
    nsv85763CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605873    OMIM disorders: --

    7 diseases for KCNK10:    About MalaCards
    dentin sensitivity    brain ischemia    maturity-onset diabetes of the young    ischemia
    cholera    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KCNK10:
    Dentin sensitivity

    KCNK10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNK10

    Export disorders for KCNK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNK10 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with KCNK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. (PubMed id 10880510)1, 2, 3, 9 Lesage F.... Lazdunski M. (2000)
    2. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PubMed id 11897838)1, 2, 9 Gu W.... Daut J. (2002)
    3. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PubMed id 18516069)1, 2 Gierten J....Thomas D. (2008)
    4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (2005)
    5. Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PubMed id 17689202)1, 9 Huang D. and Yu B. (2008)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Alternative splicing determines mRNA translation initi ation and function of human K(2P)10.1 K+ channels. (PubMed id 21669980)1 Staudacher K....Thomas D. (2011)
    8. Whole genome association scan for genetic polymorphis ms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (2011)
    9. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54207 HGNC: 6273 AceView: KCNK10 Ensembl:ENSG00000100433 euGenes: HUgn54207
    ECgene: KCNK10 Kegg: 54207 H-InvDB: KCNK10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNK10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNK10 gene:
    Search GeneIP for patents involving KCNK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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