Aliases for KCNK10 Gene
Aliases for KCNK10 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 10 2 3 5
- Potassium Channel, Two Pore Domain Subfamily K, Member 10 2 3
- Outward Rectifying Potassium Channel Protein TREK-2 3 4
- Protein Phosphatase 1, Regulatory Subunit 97 2 3
- Potassium Channel, Subfamily K, Member 10 2 3
- TREK-2 K(+) Channel Subunit 3 4
- TREK2 3 4
- Potassium Channel Subfamily K Member 10 3
External Ids for KCNK10 Gene
- HGNC: 6273
- Entrez Gene: 54207
- Ensembl: ENSG00000100433
- OMIM: 605873
- UniProtKB: P57789
Previous GeneCards Identifiers for KCNK10 Gene
- GC14M086156
- GC14M082468
- GC14M086641
- GC14M087720
- GC14M088648
- GC14M068816
- GC14M088649
- GC14M088927
- GC14M089528
- GC14M089829
- GC14M090241
Summaries for KCNK10 Gene
-
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for KCNK10 Gene
KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Dentin Sensitivity. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.
UniProtKB/Swiss-Prot for KCNK10 Gene
-
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK10 Gene
Genomics for KCNK10 Gene
Regulatory Elements for KCNK10 Gene
Enhancers for KCNK10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G088322 | 0.5 | FANTOM5 | 6.9 | +4.8 | 4801 | 0.0 | KLF1 ZNF133 EZH2 | KCNK10 SPATA7 PIR46896 |
| GH14G088269 | 0.5 | ENCODE | 6.4 | +56.3 | 56294 | 1.8 | ZNF680 HNF4A ZBTB40 | KCNK10 PIR46896 |
| GH14G087869 | 1.1 | FANTOM5 ENCODE | 2.2 | +457.0 | 456984 | 1.5 | JUN HIC1 ZFHX2 ZNF316 FOS PRDM10 MAFK EGR2 MTA2 RNF2 | KCNK10 GPR65 ENSG00000258807 ENSG00000259077 |
| GH14G088063 | 0.9 | FANTOM5 ENCODE | 1.2 | +261.4 | 261415 | 3.2 | RAD51 L3MBTL2 BHLHE40 MAX USF2 MYC MGA | GALC GPR65 KCNK10 GC14P088067 LOC101928791 |
| GH14G088306 | 0.3 | FANTOM5 | 2.8 | +20.7 | 20712 | 0.0 | SPATA7 KCNK10 PIR46896 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNK10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNK10 gene promoter:
Regulatory Element Products
Genomic Location for KCNK10 Gene
- Chromosome:
- 14
- Start:
- 88,180,103 bp from pter
- End:
- 88,326,912 bp from pter
- Size:
- 146,810 bases
- Orientation:
- Minus strand
Genomic View for KCNK10 Gene
Genes around KCNK10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q31.3 by Ensembl
- 14q31.3 by Entrez Gene
- 14q31.3 by HGNC
KCNK10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNK10 Gene
Proteins for KCNK10 Gene
-
Protein details for KCNK10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P57789-KCNKA_HUMAN
- Recommended name:
- Potassium channel subfamily K member 10
- Protein Accession:
- P57789
- B2R8T4
- B2RCT3
- B5TJL4
- Q6B014
- Q8TDK7
- Q8TDK8
- Q9HB59
Protein attributes for KCNK10 Gene
- Size:
- 538 amino acids
- Molecular mass:
- 59765 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for KCNK10 Gene
Protein Expression for KCNK10 Gene
Post-translational modifications for KCNK10 Gene
Other Protein References for KCNK10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KCNK10
-
Abcam antibodies for KCNK10
- Invitrogen Antibodies for KCNK10
- antibodies-online Antibodies for KCNK10: See all 52
- GeneTex KCNK10 antibody for KCNK10
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNK10
Protein Products
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-
Abcam proteins for KCNK10
Assay Products
No data available for DME Specific Peptides for KCNK10 Gene
Domains & Families for KCNK10 Gene
Gene Families for KCNK10 Gene
Protein Domains for KCNK10 Gene
Suggested Antigen Peptide Sequences for KCNK10 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ94053, Homo sapiens potassium channel, subfamily K, member 10 (KCNK10),transcript variant 2, mRNA (B2R8T4_HUMAN)
- Potassium channel, subfamily K, member 10, isoform CRA_c (B5TJL4_HUMAN)
- TREK-2 K(+) channel subunit (KCNKA_HUMAN)
- Potassium channel, subfamily K, member 10, isoform CRA_a (Q6B014_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P57789UniProtKB/Swiss-Prot:
KCNKA_HUMAN :- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
- Domain:
-
- Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Function for KCNK10 Gene
Molecular function for KCNK10 Gene
- UniProtKB/Swiss-Prot Function:
- Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005267 | potassium channel activity | IEA | -- |
Phenotypes for KCNK10 Gene
- MGI mutant phenotypes for KCNK10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNK10:
Animal Models for KCNK10 Gene
- MGI Knock Outs for KCNK10:
-
- Kcnk10 tm1Fles
Animal Model Products
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-
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CRISPR Products
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-
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miRNA for KCNK10 Gene
- miRTarBase miRNAs that target KCNK10
-
- hsa-mir-1185-2-3p (MIRT542092)
- hsa-mir-1185-1-3p (MIRT542093)
- hsa-let-7f-2-3p (MIRT542094)
- hsa-mir-1284 (MIRT542095)
- hsa-mir-603 (MIRT542096)
- hsa-mir-8485 (MIRT542097)
- hsa-mir-6856-3p (MIRT611014)
- hsa-mir-4264 (MIRT611015)
- hsa-mir-1910-5p (MIRT611016)
- hsa-mir-455-3p (MIRT611017)
- hsa-mir-574-3p (MIRT611018)
- hsa-mir-548x-3p (MIRT611019)
- hsa-mir-548j-3p (MIRT611020)
- hsa-mir-548aq-3p (MIRT611021)
- hsa-mir-548am-3p (MIRT611022)
- hsa-mir-548aj-3p (MIRT611023)
- hsa-mir-548ah-3p (MIRT611024)
- hsa-mir-548ae-3p (MIRT611025)
- hsa-mir-548z (MIRT611026)
- hsa-mir-548h-3p (MIRT611027)
- hsa-mir-548d-3p (MIRT611028)
- hsa-mir-548bb-3p (MIRT611029)
- hsa-mir-548ac (MIRT611030)
- hsa-mir-6799-3p (MIRT623517)
- hsa-mir-3173-5p (MIRT623518)
- hsa-mir-3189-5p (MIRT623519)
- hsa-mir-4758-3p (MIRT623520)
- hsa-mir-5699-5p (MIRT623521)
- hsa-mir-324-3p (MIRT623522)
- hsa-mir-1913 (MIRT623523)
- hsa-mir-6752-3p (MIRT623524)
- hsa-mir-186-3p (MIRT623525)
- hsa-mir-520h (MIRT623526)
- hsa-mir-520g-3p (MIRT623527)
- hsa-mir-6779-3p (MIRT623528)
- hsa-mir-548ah-5p (MIRT623529)
- hsa-mir-3609 (MIRT623530)
- hsa-mir-6793-3p (MIRT702515)
miRNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK10 Gene
Localization for KCNK10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNK10 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNK10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sweet Taste Signaling |
.37
|
|
| 2 | Cardiac conduction | ||
| 3 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | Hepatic ABC Transporters | ||
Pathways by source for KCNK10 Gene
1 BioSystems pathway for KCNK10 Gene
7 Reactome pathways for KCNK10 Gene
1 KEGG pathway for KCNK10 Gene
13 Qiagen pathways for KCNK10 Gene
Interacting Proteins for KCNK10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | TAS | 10880510 |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0007165 | signal transduction | NAS | 10880510 |
| GO:0007613 | memory | IEA | -- |
No data available for SIGNOR curated interactions for KCNK10 Gene
Drugs & Compounds for KCNK10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Halothane | Approved, Vet_approved | Pharma | Activator, antagonist | 2 | ||
| Riluzole | Approved, Investigational | Pharma | Activator, blocker | Sodium channel protein inhibitor | 65 | |
| arachidonic acid | Experimental | Nutra | Activator | 30 | ||
| BL 1249 | Pharma | Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener | 0 | |||
| DMP 543 | Pharma | K+ channel blocker and potent ACh release enhancer | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PK-THPP |
|
1332454-07-5 |
|
|
||
| Spadin |
|
1270083-24-3 |
|
|
(5) Tocris Compounds for KCNK10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BL 1249 | Putative K2P2.1 (TREK-1) channel opener | 18200-13-0 |
| DMP 543 | K+ channel blocker and potent ACh release enhancer | 160588-45-4 |
| ML 365 | Potent and selective TASK-1 channel blocker | 947914-18-3 |
| PK-THPP | Potent TASK-3 channel blocker | 1332454-07-5 |
| Spadin | Potent TREK-1 channel blocker | 1270083-24-3 |
Transcripts for KCNK10 Gene
mRNA/cDNA for KCNK10 Gene
- (4) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNK10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNK10
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNK10
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miRNA Products
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Flow Cytometry Products
Expression for KCNK10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for KCNK10 Gene
This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Putamen (basal ganglia) (x4.9), Brain - Hippocampus (x4.6), and Brain - Cerebellar Hemisphere (x4.1).
This gene is overexpressed in Skin (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK10 Gene
NURSA nuclear receptor signaling pathways regulating expression of KCNK10 Gene:
KCNK10SOURCE GeneReport for Unigene cluster for KCNK10 Gene:
Hs.560255mRNA Expression by UniProt/SwissProt for KCNK10 Gene:
P57789-KCNKA_HUMAN
Tissue specificity:
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Evidence on tissue expression from TISSUES for KCNK10 Gene
- Nervous system(4.7)
- Kidney(4.3)
- Pancreas(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for KCNK10
-
OriGene qPCR primer pairs for KCNK10
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK10 Gene
Orthologs for KCNK10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNK10 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNK10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KCNK10 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Kcnk10 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnk10 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNK10 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | KCNK10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KCNK10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnk10 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kcnk10b 34 35 |
|
||
| kcnk10a 35 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOK1 37 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6929 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for KCNK10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNK10 Gene
Variants for KCNK10 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033885 | -- | 88,250,861(+) | AAAAG(A/G)AAAGA | intron-variant | |
| rs1000047394 | -- | 88,208,760(+) | GATAT(C/G)TATTC | intron-variant | |
| rs1000108677 | -- | 88,249,007(+) | AAAGT(C/T)CTCTC | intron-variant | |
| rs1000111805 | -- | 88,268,578(+) | CCAGG(A/G)GGAAA | intron-variant | |
| rs1000114025 | -- | 88,309,313(+) | AAGGC(C/T)CAAGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2748991 | CNV | deletion | 23290073 |
| esv3433882 | CNV | insertion | 20981092 |
| esv3581376 | CNV | loss | 25503493 |
| nsv1115975 | CNV | insertion | 24896259 |
| nsv1149100 | CNV | insertion | 26484159 |
| nsv84705 | CNV | insertion | 16902084 |
| nsv85763 | CNV | deletion | 16902084 |
| nsv952880 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
5.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.10;
69.10% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNK10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNK10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK10 Gene
Disorders for KCNK10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dentin sensitivity |
|
|
Search KCNK10 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNK10
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK10 Gene
Publications for KCNK10 Gene
- Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. (PMID: 10880510) Lesage F. … Lazdunski M. (J. Biol. Chem. 2000) 2 3 4 22 64
- Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PMID: 11897838) Gu W. … Daut J. (J. Physiol. (Lond.) 2002) 3 4 22 64
- Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PMID: 17689202) Huang D. … Yu B. (Med. Hypotheses 2008) 3 22 64
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J. … Thomas D. (Br. J. Pharmacol. 2008) 3 4 64
- International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein S.A. … Rajan S. (Pharmacol. Rev. 2005) 2 3 64
Products for KCNK10 Gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNK10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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