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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNK1 Gene

protein-coding GIFtS: 63
GCID: GC01P233750

potassium channel, subfamily K, member 1

Explore 3 diseases affiliated with
KCNK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Channel, Subfamily K, Member 1¹ ²		KCNO1² ³
TWIK1² ³ ⁵		HOHO²
DPK¹ ²		K2P1²
K2p1.1¹ ²		Potassium Channel Subfamily K Member 1²
TWIK-1¹ ²		Potassium Inwardly-Rectifying Channel, Subfamily K, Member 1²
Inward Rectifying Potassium Channel Protein TWIK-1² ³		HOHO1³
Potassium Channel KCNO1² ³

External Ids:	HGNC: 6272¹	Entrez Gene: 3775²	Ensembl: ENSG00000135750⁷	OMIM: 601745⁵	UniProtKB: O00180³

Export aliases for KCNK1 gene to outside databases

Previous GC identifers: GC01P232011 GC01P229309 GC01P230077 GC01P230834 GC01P230056 GC01P231817 GC01P204240

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNK1:

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P

domains. The product of this gene has not been shown to be a functional channel, however, it may require other

non-pore-forming proteins for activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180

Function: Weakly inward rectifying potassium channel

Gene Wiki entry for KCNK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNK1 gene promoter:
NF-1/L NF-1 Pax-5 AML1a MIF-1 AP-4 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNK1 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42-q43 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42-q43

KCNK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P233750: view genomic region (about GC identifiers)

Start:	233,749,750 bp from pter	End:	233,808,258 bp from pter
Size:	58,509 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180 (See protein sequence)

Recommended Name: Potassium channel subfamily K member 1

Size: 336 amino acids; 38143 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Miscellaneous: Inhibited by barium, quinine, quinidine and internal acidification. Activated by protein kinase C

1 PDB 3D structure from and Proteopedia for KCNK1:

3UKM (3D)

Secondary accessions: Q13307 Q5T5E8

Explore the universe of human proteins at neXtProt for KCNK1: NX_O00180

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00180

KCNK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002236.1

ENSEMBL proteins:

ENSP00000355580 ENSP00000355579 ENSP00000409626

Reactome Protein details: O00180
Human Recombinant Protein Products:

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	Uscn Proteins for KCNK1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005768	endosome	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	TAS	8605869
GO:0016021	integral to membrane	--	--

KCNK1 for ontologies About GeneDecksing

KCNK1 Antibody Products:

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	Uscn ELISAs and CLIAs for KCNK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNK1 for domains About GeneDecksing

5 InterPro domains/families:

IPR003280 2pore_dom_K_chnl

IPR022306 2pore_dom_K_chnl_TASK/TWIK

IPR005408 2pore_dom_K_chnl_TWIK

IPR001779 2pore_dom_K_chnl_TWIK1

IPR013099 Ion_trans_2

Graphical View of Domain Structure for InterPro Entry O00180

ProtoNet protein and cluster: O00180

4 Blocks protein families:

IPB001779 TWIK-1 K+ channel subunit signature

IPB003280 Two pore domain K+ channel signature

IPB005408 TWIK-1/TWIK-2 K+ channel family signature

IPB013099 Ion transport 2

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180

Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180

Function: Weakly inward rectifying potassium channel

Genatlas biochemistry entry for KCNK1:

potassium non voltage-gated channel inwardly rectifying,subfamily K,member 1

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		hsa-miR-142-5p hsa-miR-3163 hsa-miR-4311 hsa-miR-539 hsa-miR-1283 hsa-miR-340 hsa-miR-583 hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: KCNK1 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005242	inward rectifier potassium channel activity	TAS	8605869
GO:0005267	potassium channel activity	--	--

KCNK1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KCNK1:

Increased G2M DNA content

Increased number of mitotic ce

Animal Models:
Mouse knock-out Kcnk1^tm1.1Barh for KCNK1
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnk1):

homeostasis/metabolism

no phenotypic analysis

renal/urinary system

KCNK1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

Sweet Taste Signaling	1.00	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.36
Cellular Effects of Sildenafil	0.46

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			PKA Signaling	0.56
	cAMP Pathway	0.77

Neuropathic Pain-Signaling in Dorsal Horn Neurons

	Neuropathic Pain-Signaling in Dorsal Horn Neurons	1.00			Cholera Infection	0.40
	Aldosterone Signaling in Epithelial Cells	0.47

Hepatic ABC Transporters

Hepatic ABC Transporters

1.00

MODY (Maturity-Onset Diabetes of Young)

0.41

Potassium Channels

Potassium Channels

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KCNK1

Potassium transporters- inward current

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNK1 (see all 13)

	Cholera Infection
	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	Hepatic ABC Transporters
	PKA Signaling
	Sweet Taste Signaling

4 Reactome Pathways for KCNK1

	Potassium Channels
	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
	Neuronal System
	Tandem pore domain potassium channels

1 PharmGKB Pathway for KCNK1

Antiarrhythmic Pathway, Pharmacodynamics

KCNK1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCNK1

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for KCNK1 (O00180³ ENSP00000355580⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SENP1	Q9P0U3³, ENSP00000394791⁴	I2D: score=2 STRING: ENSP00000394791
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=2 STRING: ENSP00000324897
SUMO1	ENSP00000376076⁴	STRING: ENSP00000376076
UBE2G2	ENSP00000338348⁴	STRING: ENSP00000338348
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	8605869
GO:0007268	synaptic transmission	TAS	--
GO:0035094	response to nicotine	IEA	--
GO:0071805	potassium ion transmembrane transport	--	--

KCNK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNK1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNK1 available from Tocris Bioscience About this table

Compound	Action	CAS #
YS-035 hydrochloride	Inhibits K+ outward/pacemaker current	[33978-72-2]
DMP 543	K+ channel blocker and potent ACh release enhancer	[160588-45-4]

1 HMDB Compound for KCNK1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Potassium	K+ (see all 16)	7440-09-7	--

3 DrugBank Compounds for KCNK1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ibutilide	Ibutilida [INN-Spanish] (see all 3)	122647-32-9	target	inhibitor	15926871 9257085
Quinidine	--	56-54-2	target	inhibitor	9003761 8605869
Quinidine barbiturate	--	--	target	inhibitor	9003761 8605869

2 Novoseek chemical compound relationships for KCNK1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
quinidine	76.7	1	9003761 (1)
quinine	67.9	1	9003761 (1)

Search CenterWatch for drugs/clinical trials and news about KCNK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNK1 gene:

NM_002245.3

Unigene Cluster for KCNK1:

Potassium channel, subfamily K, member 1

Hs.208544 [show with all ESTs]

Unigene Representative Sequence: AL833343

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366621(uc010pxo.1) ENST00000472190 ENST00000366620 ENST00000487728

ENST00000446915 ENST00000472869

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		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNK1 (see all 14):
		hsa-miR-142-5p hsa-miR-3163 hsa-miR-4311 hsa-miR-539 hsa-miR-1283 hsa-miR-340 hsa-miR-583 hsa-miR-1297

		SwitchGear 3'UTR luciferase reporter plasmid: KCNK1 3' UTR sequence

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Additional cDNA sequence:

AK090902.1 AK314016.1 AL833343.1 BC018051.1 U33632.1 U76996.1 U90065.1

7 DOTS entries:

DT.115214 DT.95170502 DT.100779125 DT.99999557 DT.100024093 DT.121394875 DT.100779122

24/104 AceView cDNA sequences (see all 104):

F03207 Z39663 BM920708 BM792236 BU678838 CA312334 BM817751 BM068723

AW044036 CK904718 AI129709 AI924793 BM785386 AA468660 AA056966 CR590911

BI830044 BF969153 BC018051 AA307980 BI666806 F10124 BI549698 U33632

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KCNK1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c
SP1:							-		-		-		-
SP2:											-		-
SP3:					-		-				-		-
SP4:					-		-		-		-		-
SP5:													-

ECgene alternative splicing isoforms for KCNK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCCACCCA

About this image

KCNK1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Ureteric Bud Tip Cells

Kidney

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Brain

Eye

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Definitive endoderm-like cells (A scalable, suspensi...)

Epiblast-like cells (Reconstitution of mo...)

Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)

Cartilage

See KCNK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNK1

SOURCE GeneReport for Unigene cluster: Hs.208544

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180

Tissue specificity: Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and

kidney

SABiosciences Expression via Pathway-Focused PCR Array including KCNK1:

Neuronal Ion Channels in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNK1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNK1 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNK1¹	potassium channel, subfamily K, member 1	84.72(n) 89.88(a)		421519 XM_419561.3 XP_419561.1
lizard (Anolis carolinensis)	Reptilia	KCNK1⁶ KCNK12⁶	--	91(a) 25(a)	1 ↔ 1 possible ortholog	1(220522363-220545443) 1(254990917-254991252)
African clawed frog (Xenopus laevis)	Amphibia	MGC53410²	similar to potassium channel, subfamily K, member 1	72.75(n)		BC042262.1
zebrafish (Danio rerio)	Actinopterygii	kcnk1a¹	potassium channel, subfamily K, member 1a	71.46(n) 72.5(a)		793480 NM_001098753.1 NP_001092223.1
worm (Caenorhabditis elegans)	Secernentea	Y39B6A.19³ twk-46¹	Protein TWK-46¹	37(a)³ 46.33(n)¹ 38.19(a)¹		V(19056869-19063586)³ 180252¹ NM_171588.3¹ NP_741678.1¹

ENSEMBL Gene Tree for KCNK1 (if available)
TreeFam Gene Tree for KCNK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNK1 gene

KCNK15² KCNK5² KCNK16² KCNK3² KCNK12² KCNK9² KCNK6² KCNK2²

KCNK18² KCNK17² KCNK10² KCNK7² KCNK4² KCNK13²

7 SIMAP similar genes for KCNK1 using alignment to 3 protein entries: KCNK1_HUMAN (see all proteins):

KCNK6 KCNK7 KCNK10 KCNK4 KCNK16 KCNK2

KCNK5

KCNK1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12072691^1,2	C,	--	233747834(+)	`GCTACG/AGCCGG`	1	--	us2k¹		3		CSA WA	121
rs138738820^1,2		--	233747920(+)	`GGTTAC/TAGAGC`	1	--	us2k¹		0	--	--	--	--
rs149347546^1,2		--	233747923(+)	`TACAGA/GGCAGG`	1	--	us2k¹		0	--	--	--	--
rs193178502^1,2		--	233748195(+)	`AGGAGC/GTAAGG`	1	--	us2k¹		0	--	--	--	--
rs78956058^1,2	C,	--	233748196(+)	`GGAGGT/AAAGGC`	1	--	us2k¹		2		NA	122
rs74145611^1,2	C,	--	233748251(+)	`TGCACA/TAGTTT`	1	--	us2k¹		3		WA CSA	121
rs114670829^1,2	C,F,	--	233748316(+)	`GTTCAG/ACTAGG`	1	--	us2k¹		1		WA	118
rs143734192^1,2		--	233748488(+)	`GGAGAC/TAGTTT`	1	--	us2k¹		0	--	--	--	--
rs185042627^1,2		--	233748698(+)	`ATTGTC/TCTGAG`	1	--	us2k¹		0	--	--	--	--
rs190189918^1,2		--	233748709(+)	`TCTTCA/GTTATT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNK1 (233749750 - 233808258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNK1
1 Indel: 71467

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KCNK1 for disorders           About GeneDecksing

OMIM gene information: 601745    OMIM disorders: --

3 diseases for KCNK1:    About MalaCards

hypokalemia atherosclerosis neuronitis

Human Genome Epidemiology (HuGE) Navigator: KCNK1 (2 documents)

Export disorders for KCNK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNK1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with KCNK1)

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TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. (PubMed id 8605869)^{1, 2, 7, 9} Lesage F....Barhanin J. (1996)
Crystal structure of the human two-pore domain potass ium channel K2P1. (PubMed id 22282804)^{1, 2} Miller A.N. and Long S.B. (2012)
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)^{1, 3} Goldstein S.A....Rajan S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. (PubMed id 9462864)^{1, 2} Goldstein S.A.N.... Pausch M.H. (1998)
Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. (PubMed id 9362344)^{1, 2} Orias M.... Desir G.V. (1997)
Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. (PubMed id 8661042)^{1, 3} Lesage F....Lazdunski M. (1996)
Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. (PubMed id 9832487)^{1, 9} Wang Z....Nattel S. (1998)
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. (PubMed id 9003761)^{7, 9} Fink M....Lazdunski M. (1996)
A role for two-pore K^+ channels in modulating Na^+ ab sorption and Cl^- secretion in normal human bronchial epithelial cells. (PubMed id 21964404)¹ Zhao K.Q....Kreindler J.L. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3775	HGNC: 6272	AceView: KCNK1	Ensembl:ENSG00000135750	euGenes: HUgn3775
ECgene: KCNK1	H-InvDB: KCNK1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNK1 gene:
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potassium channel, subfamily K, member 1

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KCNK1 Gene

potassium channel, subfamily K, member 1

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