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KCNK1 Gene(Protein Coding)

Potassium Two Pore Domain Channel Subfamily K Member 1

GCID:
GC01P233614
GIFtS:
61
Genes Participants
UDN Logo

Aliases for KCNK1 Gene

Aliases for KCNK1 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 1 2 3 5
  • Tandem Of P Domains In A Weak Inward Rectifying K+ Channel 1 2 3
  • Potassium Channel, Two Pore Domain Subfamily K, Member 1 2 3
  • Inward Rectifying Potassium Channel Protein TWIK-1 3 4
  • Potassium Channel KCNO1 3 4
  • Potassium Channel K2P1 3 4
  • KCNO1 3 4
  • TWIK1 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 1 3
  • Potassium Channel, Subfamily K, Member 1 2
  • Potassium Channel Subfamily K Member 1 3
  • K2p1.1 3
  • TWIK-1 3
  • HOHO1 4
  • HOHO 3
  • K2P1 3
  • DPK 3

External Ids for KCNK1 Gene

Previous GeneCards Identifiers for KCNK1 Gene

  • GC01P232011
  • GC01P229309
  • GC01P230077
  • GC01P230834
  • GC01P230056
  • GC01P231817
  • GC01P233750
  • GC01P204240

Summaries for KCNK1 Gene

Entrez Gene Summary for KCNK1 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK1 Gene

KCNK1 (Potassium Two Pore Domain Channel Subfamily K Member 1) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK6.

UniProtKB/Swiss-Prot for KCNK1 Gene

  • Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).

Tocris Summary for KCNK1 Gene

Gene Wiki entry for KCNK1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK1 Gene

Genomics for KCNK1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for KCNK1 Gene

Enhancers for KCNK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G233667 1.3 Ensembl ENCODE 28.8 +54.9 54860 1.9 HDGF PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 GATA2 FOS JUNB KCNK1 TARBP1 GC01P233696 MIR4427
GH01G233654 1.2 ENCODE dbSUPER 25.6 +41.7 41698 2.4 HDGF PKNOX1 SIN3A FEZF1 ZNF2 ZNF766 GATA2 ZNF143 FOS ZNF263 KCNK1 MIR4427 GC01P233696
GH01G233672 1.5 FANTOM5 ENCODE dbSUPER 16.2 +59.9 59915 2.5 HDGF HDAC1 TBP CREB3L1 RAD21 CHAMP1 YY1 TCF12 ZNF766 GATA2 KCNK1 GC01P233696 MIR4427
GH01G233635 1.2 ENCODE 18.9 +22.1 22100 1.6 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF302 ZNF416 RPS7P3 IRF2BP2 KCNK1 MIR4427 GC01P233696
GH01G233720 0.8 FANTOM5 24.1 +107.2 107151 0.4 PKNOX1 MAX CEBPG FEZF1 BMI1 RAD21 RFX5 YY1 POLR3A ELK1 KCNK1 TARBP1 GC01P233727 GC01M233697
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNK1 on UCSC Golden Path with GeneCards custom track

Promoters for KCNK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022008 396 2001 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF263

Transcription factor binding sites by QIAGEN in the KCNK1 gene promoter:

Genomic Location for KCNK1 Gene

Chromosome:
1
Start:
233,614,004 bp from pter
End:
233,672,512 bp from pter
Size:
58,509 bases
Orientation:
Plus strand

Genomic View for KCNK1 Gene

Genes around KCNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KCNK1 Gene

Proteins for KCNK1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KCNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00180-KCNK1_HUMAN
    Recommended name:
    Potassium channel subfamily K member 1
    Protein Accession:
    O00180
    Secondary Accessions:
    • Q13307
    • Q5T5E8

    Protein attributes for KCNK1 Gene

    Size:
    336 amino acids
    Molecular mass:
    38143 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:8978667, PubMed:22282804). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (PubMed:23169818). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (PubMed:15820677).
    Miscellaneous:
    • When the external K(+) concentration is lowered to subphysiological levels, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed:21653227). Likewise, when the external pH is lowered to values below 6.5, it takes several minutes till the channel has reached a new, stable state characterized by increased Na(+) permeability (PubMed:22431633). When raising the K(+) concentration back to 5 mM, it takes 40 to 70 minutes for the channel to regain its original selectivity for K(+) (PubMed:21653227). Likewise, it takes more that 25 minutes for the channel to regain its original K(+) selectivity when the pH is raised back to 7.4 (PubMed:22431633).

    Three dimensional structures from OCA and Proteopedia for KCNK1 Gene

neXtProt entry for KCNK1 Gene

Protein Expression for KCNK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KCNK1 Gene

  • Sumoylation is controversial. Sumoylated by UBE2I (PubMed:15820677). Not sumoylated when expressed in xenopus oocytes or mammalian cells (PubMed:17693262). Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane (PubMed:15820677). Sumoylation of a single subunit is sufficient to silence the dimeric channel (PubMed:20498050, PubMed:23169818). Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9 (PubMed:23169818). Desumoylated by SENP1; this activates the channel (PubMed:15820677, PubMed:20498050, PubMed:23169818). Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9 (PubMed:23169818). SENP1 treatment has no effect (PubMed:17693262).
  • Glycosylation at posLast=9595
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KCNK1

No data available for DME Specific Peptides for KCNK1 Gene

Domains & Families for KCNK1 Gene

Gene Families for KCNK1 Gene

HGNC:
IUPHAR :

Protein Domains for KCNK1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00180

UniProtKB/Swiss-Prot:

KCNK1_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK1: view

Function for KCNK1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for KCNK1 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Note=Has a unit conductance of 34 pS. Both activation and channel closure are very rapid. Is not voltage-gated. The relationship between voltage and current is nearly linear. Has a mean open time of 0.3 msec at a membrane potential of -80 mV, and 1.9 msec at +80 mV (PubMed:8605869). {ECO:0000269 PubMed:19959478, ECO:0000269 PubMed:8605869};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Ba(2+) ions and quinidine (PubMed:8605869). Inhibited by quinine (PubMed:8605869, PubMed:21653227). Is slightly inhibited by 10 mM tetraethylammonium (TEA), and only marginally inhibited by 4-aminopyridine, charybdotoxin and dendrotoxin (PubMed:8605869). Lowering the extracellular pH to below 6.5 transiently activates the channel, and then inhibits channel activity (PubMed:15820677, PubMed:22431633). Inhibited when the intracellular pH is decreased down to pH 6.0, but this may be due to indirect effects (PubMed:8605869).
UniProtKB/Swiss-Prot Function:
Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).

Gene Ontology (GO) - Molecular Function for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 8605869
GO:0005249 NOT voltage-gated potassium channel activity IDA 21653227
GO:0005267 potassium channel activity TAS,IEA --
GO:0005272 sodium channel activity IDA 21653227
GO:0022841 potassium ion leak channel activity IEA,IDA 21653227
genes like me logo Genes that share ontologies with KCNK1: view
genes like me logo Genes that share phenotypes with KCNK1: view

Animal Models for KCNK1 Gene

MGI Knock Outs for KCNK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK1

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK1 Gene

Localization for KCNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK1 Gene

Cell membrane; Multi-pass membrane protein. Recycling endosome. Cell junction, synapse. Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cell projection. Apical cell membrane; Multi-pass membrane protein. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected in synaptic membranes. Detected at the apical cell membrane in stria vascularis in the cochlea. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3. Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity). Detected at the apical cell membrane of bronchial epithelial cells (PubMed:21964404). {ECO:0000250 UniProtKB:O08581, ECO:0000250 UniProtKB:Q9Z2T2, ECO:0000269 PubMed:21964404}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK1 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 1

Gene Ontology (GO) - Cellular Components for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0008076 voltage-gated potassium channel complex TAS 8605869
genes like me logo Genes that share ontologies with KCNK1: view

Pathways & Interactions for KCNK1 Gene

genes like me logo Genes that share pathways with KCNK1: view

Gene Ontology (GO) - Biological Process for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,TAS 8605869
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0035094 response to nicotine IEA --
genes like me logo Genes that share ontologies with KCNK1: view

No data available for SIGNOR curated interactions for KCNK1 Gene

Drugs & Compounds for KCNK1 Gene

Products:

  1. Drug

(8) Drugs for KCNK1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quinidine Approved Pharma Pore Blocker, Target, inhibitor 45
Ibutilide Approved Pharma Target, inhibitor 5
Quinidine barbiturate Approved Pharma Target, inhibitor 0
Potassium Approved Pharma 0
BL 1249 Pharma Putative activator of potassium TREK-1, Putative K2P2.1 (TREK-1) channel opener 0

(2) Additional Compounds for KCNK1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PK-THPP
1332454-07-5
Spadin
1270083-24-3

(5) Tocris Compounds for KCNK1 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener 18200-13-0
DMP 543 K+ channel blocker and potent ACh release enhancer 160588-45-4
ML 365 Potent and selective TASK-1 channel blocker 947914-18-3
PK-THPP Potent TASK-3 channel blocker 1332454-07-5
Spadin Potent TREK-1 channel blocker 1270083-24-3

(1) ApexBio Compounds for KCNK1 Gene

Compound Action Cas Number
Quinidine 56-54-2
genes like me logo Genes that share compounds with KCNK1: view

Transcripts for KCNK1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KCNK1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(104) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK1 Gene

Potassium channel, subfamily K, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - -

Relevant External Links for KCNK1 Gene

GeneLoc Exon Structure for
KCNK1
ECgene alternative splicing isoforms for
KCNK1

Expression for KCNK1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK1 Gene

mRNA expression in normal human tissues for KCNK1 Gene
mRNA expression by BioGPS for KCNK1 GenemRNA expression by GTEx for KCNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1) and Brain - Cerebellum (x6.6).

Protein differential expression in normal tissues from HIPED for KCNK1 Gene

This gene is overexpressed in Retina (46.7) and Placenta (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCNK1 Gene



Protein tissue co-expression partners for KCNK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNK1 Gene:

KCNK1

SOURCE GeneReport for Unigene cluster for KCNK1 Gene:

Hs.208544

mRNA Expression by UniProt/SwissProt for KCNK1 Gene:

O00180-KCNK1_HUMAN
Tissue specificity: Detected in bronchial epithelial cells (PubMed:21964404). Detected in heart left atrium and left ventricle (PubMed:17478540). Detected in cardiac myocytes (at protein level) (PubMed:21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540). Detected in bronchial epithelial cells (PubMed:21964404).

Evidence on tissue expression from TISSUES for KCNK1 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with KCNK1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK1 Gene

Orthologs for KCNK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KCNK1 34 35
  • 99.11 (n)
oppossum
(Monodelphis domestica)
 Mammalia KCNK1 35
  • 95 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Kcnk1 34
  • 90.08 (n)
cow
(Bos Taurus)
 Mammalia KCNK1 34 35
  • 89.88 (n)
mouse
(Mus musculus)
 Mammalia Kcnk1 34 16 35
  • 88.89 (n)
dog
(Canis familiaris)
 Mammalia KCNK1 35
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KCNK1 35
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KCNK1 34 35
  • 84.72 (n)
lizard
(Anolis carolinensis)
 Reptilia KCNK1 35
  • 91 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia kcnk1 34
  • 72.05 (n)
Str.11974 34
African clawed frog
(Xenopus laevis)
 Amphibia MGC53410 34
zebrafish
(Danio rerio)
 Actinopterygii kcnk1b 35
  • 72 (a)
 OneToMany
kcnk1a 34 35
  • 70.68 (n)
worm
(Caenorhabditis elegans)
 Secernentea twk-46 34
  • 47.37 (n)
Y39B6A.19 36
  • 37 (a)
Species where no ortholog for KCNK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK1 Gene

ENSEMBL:
Gene Tree for KCNK1 (if available)
TreeFam:
Gene Tree for KCNK1 (if available)

Paralogs for KCNK1 Gene

Paralogs for KCNK1 Gene

(7) SIMAP similar genes for KCNK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK1: view

Variants for KCNK1 Gene

Sequence variations from dbSNP and Humsavar for KCNK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000019055 -- 233,646,861(+) AAGCC(A/G)CTGGT intron-variant
rs1000041845 -- 233,646,559(+) TTATT(C/T)TGGTA intron-variant
rs1000125682 -- 233,628,650(+) AGCTA(C/T)TTGGG intron-variant, upstream-variant-2KB
rs1000152106 -- 233,614,686(+) CCGAC(C/T)CTCCG intron-variant
rs1000156622 -- 233,656,812(+) CAGAG(C/T)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK1 Gene

Variant ID Type Subtype PubMed ID
dgv584n100 CNV loss 25217958
esv27945 CNV loss 19812545
nsv522207 CNV loss 19592680
nsv528071 CNV loss 19592680
nsv827287 CNV gain 20364138
nsv827298 CNV gain 20364138

Variation tolerance for KCNK1 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK1 Gene

Disorders for KCNK1 Gene

Relevant External Links for KCNK1

Genetic Association Database (GAD)
KCNK1
Human Genome Epidemiology (HuGE) Navigator
KCNK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNK1

No disorders were found for KCNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK1 Gene

Publications for KCNK1 Gene

  1. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. (PMID: 8605869) Lesage F. … Barhanin J. (EMBO J. 1996) 3 4 22 25 64
  2. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. (PMID: 25001086) Aryal P. … Tucker S.J. (Nat. Commun. 2014) 3 4 64
  3. A role for two-pore Ka8_ channels in modulating Naa8_ absorption and Cla8> secretion in normal human bronchial epithelial cells. (PMID: 21964404) Zhao K.Q. … Kreindler J.L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012) 3 4 64
  4. Crystal structure of the human two-pore domain potassium channel K2P1. (PMID: 22282804) Miller A.N. … Long S.B. (Science 2012) 3 4 64
  5. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia. (PMID: 21653227) Ma L. … Chen H. (Sci Signal 2011) 3 4 64

Products for KCNK1 Gene

Sources for KCNK1 Gene

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