Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNK1 Gene

Aliases for KCNK1 Gene

  • Potassium Channel, Two Pore Domain Subfamily K, Member 1 2 3
  • TWIK1 3 4 6
  • Tandem Of P Domains In A Weak Inward Rectifying K+ Channel 1 2 3
  • Inward Rectifying Potassium Channel Protein TWIK-1 3 4
  • Potassium Channel KCNO1 3 4
  • KCNO1 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 1 3
  • Potassium Channel, Subfamily K, Member 1 2
  • Potassium Channel Subfamily K Member 1 3
  • K2p1.1 3
  • TWIK-1 3
  • HOHO1 4
  • HOHO 3
  • K2P1 3
  • DPK 3

External Ids for KCNK1 Gene

Previous GeneCards Identifiers for KCNK1 Gene

  • GC01P232011
  • GC01P229309
  • GC01P230077
  • GC01P230834
  • GC01P230056
  • GC01P231817
  • GC01P233750
  • GC01P204240

Summaries for KCNK1 Gene

Entrez Gene Summary for KCNK1 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK1 Gene

KCNK1 (Potassium Channel, Two Pore Domain Subfamily K, Member 1) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNK3.

UniProtKB/Swiss-Prot for KCNK1 Gene

  • Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.

Tocris Summary for KCNK1 Gene

Gene Wiki entry for KCNK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK1 Gene

Genomics for KCNK1 Gene

Regulatory Elements for KCNK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNK1 Gene

233,614,004 bp from pter
233,672,512 bp from pter
58,509 bases
Plus strand

Genomic View for KCNK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK1 Gene

Proteins for KCNK1 Gene

  • Protein details for KCNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 1
    Protein Accession:
    Secondary Accessions:
    • Q13307
    • Q5T5E8

    Protein attributes for KCNK1 Gene

    336 amino acids
    Molecular mass:
    38143 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for KCNK1 Gene

neXtProt entry for KCNK1 Gene

Proteomics data for KCNK1 Gene at MOPED

Post-translational modifications for KCNK1 Gene

  • Glycosylation at Asn95
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNK1 Gene

Domains for KCNK1 Gene

Suggested Antigen Peptide Sequences for KCNK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK1: view

Function for KCNK1 Gene

Molecular function for KCNK1 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Note=Activation is very rapid, but inactivation is very slow. {ECO:0000269 PubMed:8605869};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Ba(2+) ions, quinine and quinidine (PubMed:8605869). Is not inhibited by 4-aminopyridine, charybdotoxin and dendrotoxin, and is only marginally inhibited by 10 mM TEA (PubMed:8605869).
UniProtKB/Swiss-Prot Function:
Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.

Gene Ontology (GO) - Molecular Function for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 8605869
GO:0005267 potassium channel activity IDA 22282804
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK1: view
genes like me logo Genes that share phenotypes with KCNK1: view

Animal Models for KCNK1 Gene

MGI Knock Outs for KCNK1:

Animal Model Products

miRNA for KCNK1 Gene

miRTarBase miRNAs that target KCNK1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KCNK1 Gene

Localization for KCNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNK1 Gene COMPARTMENTS Subcellular localization image for KCNK1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endosome 2

Gene Ontology (GO) - Cellular Components for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0008076 voltage-gated potassium channel complex TAS 8605869
genes like me logo Genes that share ontologies with KCNK1: view

Pathways for KCNK1 Gene

genes like me logo Genes that share pathways with KCNK1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KCNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 8605869
GO:0007268 synaptic transmission TAS --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0035094 response to nicotine IEA --
genes like me logo Genes that share ontologies with KCNK1: view

Drugs for KCNK1 Gene

(3) Drugbank Compounds for KCNK1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Corvert
122647-32-9 60753 Target inhibitor approved
  • (+)-quinidine
56-54-2 441074 Target inhibitor approved
Quinidine barbiturate
Target inhibitor approved

(5) Tocris Compounds for KCNK1 Gene

Compound Action Cas Number
BL 1249 Putative K2P2.1 (TREK-1) channel opener [18200-13-0]
Cesium chloride Potassium channel blocker; neuroprotective [7647-17-8]
DMP 543 K+ channel blocker and potent ACh release enhancer [160588-45-4]
ML 365 Potent and selective TASK-1 channel blocker [947914-18-3]
YS-035 hydrochloride Inhibits K+ outward/pacemaker current [89805-39-0]

(4) HMDB Compounds for KCNK1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ibutilida [INN-Spanish]
  • K+
  • Quinidine Sulfate
Quinidine barbiturate

(2) Novoseek inferred chemical compound relationships for KCNK1 Gene

Compound -log(P) Hits PubMed IDs
quinidine 76.7 1
quinine 67.9 1
genes like me logo Genes that share compounds with KCNK1: view

Transcripts for KCNK1 Gene

Unigene Clusters for KCNK1 Gene

Potassium channel, subfamily K, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: -
SP6: - - - -

Relevant External Links for KCNK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK1 Gene

mRNA expression in normal human tissues for KCNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.1) and Brain - Cerebellum (6.6).

Protein differential expression in normal tissues for KCNK1 Gene

This gene is overexpressed in Retina (46.7) and Placenta (22.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNK1 Gene

SOURCE GeneReport for Unigene cluster for KCNK1 Gene Hs.208544

mRNA Expression by UniProt/SwissProt for KCNK1 Gene

Tissue specificity: Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney (PubMed:8605869).
genes like me logo Genes that share expressions with KCNK1: view

Expression partners for KCNK1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for KCNK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK1 35
  • 89.88 (n)
  • 94.35 (a)
KCNK1 36
  • 94 (a)
(Mus musculus)
Mammalia Kcnk1 35
  • 88.89 (n)
  • 94.94 (a)
Kcnk1 16
Kcnk1 36
  • 95 (a)
(Pan troglodytes)
Mammalia KCNK1 35
  • 99.11 (n)
  • 100 (a)
KCNK1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnk1 35
  • 90.08 (n)
  • 96.43 (a)
(Canis familiaris)
Mammalia KCNK1 36
  • 82 (a)
(Monodelphis domestica)
Mammalia KCNK1 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK1 36
  • 75 (a)
(Gallus gallus)
Aves KCNK1 35
  • 84.72 (n)
  • 89.88 (a)
KCNK1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia KCNK1 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk1 35
  • 72.05 (n)
  • 70.73 (a)
Str.11974 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53410 35
(Danio rerio)
Actinopterygii kcnk1a 35
  • 70.68 (n)
  • 70.78 (a)
kcnk1a 36
  • 69 (a)
kcnk1b 36
  • 72 (a)
(Caenorhabditis elegans)
Secernentea Y39B6A.19 37
  • 37 (a)
twk-46 35
  • 47.37 (n)
  • 39.27 (a)
Species with no ortholog for KCNK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK1 Gene

Gene Tree for KCNK1 (if available)
Gene Tree for KCNK1 (if available)

Paralogs for KCNK1 Gene

(7) SIMAP similar genes for KCNK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNK1: view

Variants for KCNK1 Gene

Sequence variations from dbSNP and Humsavar for KCNK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs16360 -- 233,672,140(-) ATCTA(-/TA)GTCTT utr-variant-3-prime
rs485755 -- 233,626,889(-) aatta(C/T)ataaa intron-variant
rs518032 -- 233,647,965(-) AGGGA(A/C)CAAAT intron-variant
rs521777 -- 233,654,106(-) gccaa(A/C)gttct intron-variant
rs538213 -- 233,619,194(-) aaaat(A/G)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK1 Gene

Variant ID Type Subtype PubMed ID
nsv827287 CNV Gain 20364138
nsv827298 CNV Gain 20364138
nsv528071 CNV Loss 19592680
esv27945 CNV Loss 19812545
nsv522207 CNV Loss 19592680

Relevant External Links for KCNK1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK1 Gene

Disorders for KCNK1 Gene

Relevant External Links for KCNK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KCNK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCNK1 Gene

Publications for KCNK1 Gene

  1. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. (PMID: 8605869) Lesage F. … Barhanin J. (EMBO J. 1996) 3 4 23 25 26
  2. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. (PMID: 9003761) Fink M. … Lazdunski M. (EMBO J. 1996) 23 25 26
  3. Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. (PMID: 8661042) Lesage F. … Lazdunski M. (Genomics 1996) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. (PMID: 9362344) Orias M. … Desir G.V. (Am. J. Physiol. 1997) 3 4

Products for KCNK1 Gene

Sources for KCNK1 Gene

Back to Top