Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNK1 Gene

protein-coding   GIFtS: 66
GCID: GC01P233750

Potassium Channel, Subfamily K, Member 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Channel, Subfamily K, Member 11 2     K2P12
TWIK12 3 5     K2p1.12
Inward Rectifying Potassium Channel Protein TWIK-12 3     TWIK-12
Potassium Channel KCNO12 3     Potassium Channel Subfamily K Member 12
KCNO12 3     Potassium Inwardly-Rectifying Channel, Subfamily K, Member 12
DPK2     HOHO13
HOHO2     

External Ids:    HGNC: 62721   Entrez Gene: 37752   Ensembl: ENSG000001357507   OMIM: 6017455   UniProtKB: O001803   

Export aliases for KCNK1 gene to outside databases

Previous GC identifers: GC01P232011 GC01P229309 GC01P230077 GC01P230834 GC01P230056 GC01P231817 GC01P204240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KCNK1 Gene:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming
P domains. The product of this gene has not been shown to be a functional channel, however, it may require other
non-pore-forming proteins for activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNK1 Gene:
KCNK1 (potassium channel, subfamily K, member 1) is a protein-coding gene. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNK15.

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180
Function: Weakly inward rectifying potassium channel

Gene Wiki entry for KCNK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNK1 gene promoter:
         NF-1/L   NF-1   Pax-5   AML1a   MIF-1   AP-4   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNK1 promoter sequence
   Search Chromatin IP Primers for KCNK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42-q43   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42-q43

KCNK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P233750:  view genomic region     (about GC identifiers)

Start:
233,749,750 bp from pter      End:
233,808,258 bp from pter
Size:
58,509 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180 (See protein sequence)
Recommended Name: Potassium channel subfamily K member 1  
Size: 336 amino acids; 38143 Da
Subunit: Homodimer; disulfide-linked
Miscellaneous: Inhibited by barium, quinine, quinidine and internal acidification. Activated by protein kinase C
1 PDB 3D structure from and Proteopedia for KCNK1:
3UKM (3D)    
Secondary accessions: Q13307 Q5T5E8

Explore the universe of human proteins at neXtProt for KCNK1: NX_O00180

Explore proteomics data for KCNK1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95
  • Modification sites at PhosphoSitePlus

  • See KCNK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002236.1  
    ENSEMBL proteins: 
     ENSP00000355580   ENSP00000355579   ENSP00000409626  
    Reactome Protein details: O00180

    KCNK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNK1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCNK1
    GenScript Custom Purified and Recombinant Proteins Services for KCNK1
    Novus Biologicals KCNK1 Protein
    Novus Biologicals KCNK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNK1

     
    Search eBioscience for Proteins for KCNK1 

    KCNK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNK1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNK1
    OriGene Custom Antibody Services for KCNK1
    Novus Biologicals KCNK1 Antibodies
    Abcam antibodies for KCNK1
    Cloud-Clone Corp. Antibodies for KCNK1
    Search ThermoFisher Antibodies for KCNK1
    LSBio Antibodies in human, mouse, rat for KCNK1

    KCNK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNK1
    Cloud-Clone Corp. CLIAs for KCNK1
    Search eBioscience for ELISAs for KCNK1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KCN: Potassium channels
    KCNK: Voltage-gated ion channels / Potassium channels, Two-P

    IUPHAR Guide to PHARMACOLOGY protein family classification: K2P1.1
    Two-P potassium channels

    5 InterPro protein domains:
     IPR003280 2pore_dom_K_chnl
     IPR005408 2pore_dom_K_chnl_TWIK
     IPR001779 2pore_dom_K_chnl_TWIK1
     IPR013099 2pore_dom_K_chnl_dom
     IPR003092 2pore_dom_K_chnl_TASK

    Graphical View of Domain Structure for InterPro Entry O00180

    ProtoNet protein and cluster: O00180

    4 Blocks protein domains:
    IPB001779 TWIK-1 K+ channel subunit signature
    IPB003280 Two pore domain K+ channel signature
    IPB005408 TWIK-1/TWIK-2 K+ channel family signature
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180
    Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family


    Find genes that share domains with KCNK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNK1_HUMAN, O00180
    Function: Weakly inward rectifying potassium channel

         Genatlas biochemistry entry for KCNK1:
    potassium non voltage-gated channel inwardly rectifying,subfamily K,member 1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity TAS8605869
    GO:0005267potassium channel activity ----
         
    Find genes that share ontologies with KCNK1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNK1:
     Increased G2M DNA content  Increased number of mitotic ce 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnk1):
     homeostasis/metabolism  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with KCNK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnk1tm1.1Barh for KCNK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target KCNK1:
    hsa-mir-124-3p (MIRT022480), hsa-mir-33a-5p (MIRT028202), hsa-mir-340-5p (MIRT019653)

    Block miRNA regulation of human, mouse, rat KCNK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNK1 (see all 14):
    hsa-miR-142-5p hsa-miR-3163 hsa-miR-4311 hsa-miR-539 hsa-miR-1283 hsa-miR-340 hsa-miR-583 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidKCNK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCNK1
    Predesigned siRNA for gene silencing in human, mouse, rat KCNK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNK1

    Clone
    Products:
         
    OriGene clones in human, mouse for KCNK1 (see all 7)
    OriGene ORF clones in mouse, rat for KCNK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNK1 (NM_002245)
    Sino Biological Human cDNA Clone for KCNK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCNK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KCNK1_HUMAN, O00180: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    endosome2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS8605869
    GO:0016020membrane ----

    Find genes that share ontologies with KCNK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCNK1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Melatonin Signaling0.72
    Sperm Motility0.37
    Cellular Effects of Sildenafil0.46
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    Cholera Infection0.40
    Aldosterone Signaling in Epithelial Cells0.47
    4Potassium Channels
    Potassium Channels0.43
    Tandem pore domain potassium channels0.00
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)0.00
    5Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    MODY (Maturity-Onset Diabetes of Young)0.41


    Find genes that share SuperPaths with KCNK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNK1 (see all 13)
        Cholera Infection
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Hepatic ABC Transporters
    PKA Signaling
    Sweet Taste Signaling


    1 Reactome Pathway for KCNK1
        Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)

    1 PharmGKB Pathway for KCNK1
        Antiarrhythmic Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNK1: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KCNK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for KCNK1 (O001803 ENSP000003555804) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SENP1Q9P0U33, ENSP000003947914I2D: score=2 STRING: ENSP00000394791
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    SUMO1ENSP000003760764STRING: ENSP00000376076
    UBE2G2ENSP000003383484STRING: ENSP00000338348
    BMPERENSP000002971614STRING: ENSP00000297161
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8605869
    GO:0007268synaptic transmission TAS--
    GO:0035094response to nicotine IEA--
    GO:0071805potassium ion transmembrane transport ----

    Find genes that share ontologies with KCNK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Cesium chloridePotassium channel blocker; neuroprotective[7647-17-8]
    YS-035 hydrochlorideInhibits K+ outward/pacemaker current[33978-72-2]
    BL 1249Putative K2P2.1 (TREK-1) channel opener[18200-13-0]
    DMP 543K+ channel blocker and potent ACh release enhancer[160588-45-4]
    Tetraethylammonium chlorideNon-selective K+ channel blocker[56-34-8]

    1 HMDB Compound for KCNK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PotassiumK+ (see all 16)7440-09-7--

    3 DrugBank Compounds for KCNK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetinhibitor15926871 9257085
    Quinidine-- 56-54-2targetinhibitor9003761 8605869
    Quinidine barbiturate-- --targetinhibitor9003761 8605869

    2 Novoseek inferred chemical compound relationships for KCNK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    quinidine 76.7 1 9003761 (1)
    quinine 67.9 1 9003761 (1)



    Find genes that share compounds with KCNK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCNK1 gene: 
    NM_002245.3  

    Unigene Cluster for KCNK1:

    Potassium channel, subfamily K, member 1
    Hs.208544  [show with all ESTs]
    Unigene Representative Sequence: AL833343
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366621(uc010pxo.1) ENST00000472190 ENST00000366620 ENST00000487728
    ENST00000446915 ENST00000472869
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCNK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNK1 (see all 14):
    hsa-miR-142-5p hsa-miR-3163 hsa-miR-4311 hsa-miR-539 hsa-miR-1283 hsa-miR-340 hsa-miR-583 hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidKCNK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCNK1
    Predesigned siRNA for gene silencing in human, mouse, rat KCNK1
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNK1 (see all 7)
    OriGene ORF clones in mouse, rat for KCNK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KCNK1 (NM_002245)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNK1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNK1
      QuantiTect SYBR Green Assays in human, mouse, rat KCNK1
      QuantiFast Probe-based Assays in human, mouse, rat KCNK1

    Additional mRNA sequence: 

    AK090902.1 AK314016.1 AL833343.1 BC018051.1 U33632.1 U76996.1 U90065.1 

    7 DOTS entries:

    DT.115214  DT.95170502  DT.100779125  DT.99999557  DT.100024093  DT.121394875  DT.100779122 

    Selected AceView cDNA sequences (see all 104):

    BM785386 BM068723 AI924793 BM817751 AA468660 AA056966 CK904718 F03207 
    BM792236 AI129709 CR590911 CA312334 AW044036 Z39663 BU678838 BM920708 
    CF456321 NM_002245 N46450 AA969458 CB104676 BI830044 BM738723 AA308453 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNK1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                    -     -     -     -                                 
    SP2:                                -     -                                 
    SP3:              -     -           -     -                                 
    SP4:              -     -     -     -     -                                 
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for KCNK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCNK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCACCCA
    KCNK1 Expression
    About this image


    KCNK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Cartilage (Muscoskeletal System)
             Intervertebral disc (IVD) annulus fibrosus (AF) cells
    KCNK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.208544

    UniProtKB/Swiss-Prot: KCNK1_HUMAN, O00180
    Tissue specificity: Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver
    and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNK1: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNK1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNK1
    QuantiTect SYBR Green Assays in human, mouse, rat KCNK1
    QuantiFast Probe-based Assays in human, mouse, rat KCNK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KCNK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnk11 , 5 potassium channel, subfamily K, member 11, 5 88.89(n)1
    94.94(a)1
      8 (73.67 cM)5
    165251  NM_008430.21  NP_032456.21 
     1259951025 
    chicken
    (Gallus gallus)
    Aves KCNK11 potassium channel, subfamily K, member 1 84.72(n)
    89.88(a)
      421519  XM_419561.4  XP_419561.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNK16
    potassium channel, subfamily K, member 1
    91(a)
    1 ↔ 1
    1(220519470-220545443)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC534102 similar to potassium channel, subfamily K, member 1 72.75(n)    BC042262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnk1a1 potassium channel, subfamily K, member 1a 70.68(n)
    70.78(a)
      793480  NM_001098753.2  NP_001092223.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.193
    twk-461
    twk-461 37(a)3
    47.37(n)1
    39.27(a)1
      V(19056869-19063586)3
    1802521  NM_171588.41  NP_741678.11 


    ENSEMBL Gene Tree for KCNK1 (if available)
    TreeFam Gene Tree for KCNK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCNK1 gene
    KCNK152  KCNK52  KCNK162  KCNK32  KCNK122  KCNK92  KCNK62  KCNK22  
    KCNK102  KCNK72  KCNK172  KCNK42  KCNK132  
    7 SIMAP similar genes for KCNK1 using alignment to 3 protein entries:     KCNK1_HUMAN (see all proteins):
    KCNK6    KCNK7    KCNK10    KCNK4    KCNK16    KCNK2
    KCNK5

    Find genes that share paralogs with KCNK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCNK1 (see all 1251)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120726911,2
    C--233747834(+) GCTACG/AGCCGG 1 -- us2k13Minor allele frequency- A:0.15CSA WA 121
    rs1387388201,2
    --233747920(+) GGTTAC/TAGAGC 1 -- us2k10--------
    rs1493475461,2
    --233747923(+) TACAGA/GGCAGG 1 -- us2k10--------
    rs1931785021,2
    --233748195(+) AGGAGC/GTAAGG 1 -- us2k10--------
    rs789560581,2
    C,F--233748196(+) GGAGGT/AAAGGC 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs741456111,2
    C,F--233748251(+) TGCACA/TAGTTT 1 -- us2k13Minor allele frequency- T:0.10WA CSA 121
    rs1146708291,2
    C,F--233748316(+) GTTCAG/ACTAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1437341921,2
    --233748488(+) GGAGAC/TAGTTT 1 -- us2k10--------
    rs1850426271,2
    --233748698(+) ATTGTC/TCTGAG 1 -- us2k10--------
    rs1901899181,2
    --233748709(+) TCTTCA/GTTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNK1 (233749750 - 233808258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27945CNV Loss19812545
    nsv528071CNV Loss19592680
    nsv522207CNV Loss19592680
    nsv827298CNV Gain20364138
    nsv827287CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNK1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601745    OMIM disorders: --


    Find genes that share disorders with KCNK1           About GenesLikeMe

    Genetic Association Database (GAD): KCNK1
    Human Genome Epidemiology (HuGE) Navigator: KCNK1 (2 documents)

    Export disorders for KCNK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCNK1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with KCNK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. (PubMed id 8605869)1, 2, 7, 9 Lesage F....Barhanin J. (EMBO J. 1996)
    2. Crystal structure of the human two-pore domain potassium channel K2P1. (PubMed id 22282804)1, 2 Miller A.N. and Long S.B. (Science 2012)
    3. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    4. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PubMed id 16382106)1, 3 Goldstein S.A....Rajan S. (Pharmacol. Rev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. (PubMed id 9462864)1, 2 Goldstein S.A.N.... Pausch M.H. (J. Mol. Med. 1998)
    7. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. (PubMed id 9362344)1, 2 Orias M.... Desir G.V. (Am. J. Physiol. 1997)
    8. Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. (PubMed id 8661042)1, 3 Lesage F....Lazdunski M. (Genomics 1996)
    9. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. (PubMed id 9832487)1, 9 Wang Z....Nattel S. (Circulation 1998)
    10. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. (PubMed id 9003761)7, 9 Fink M....Lazdunski M. (EMBO J. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3775 HGNC: 6272 AceView: KCNK1 Ensembl:ENSG00000135750 euGenes: HUgn3775
    ECgene: KCNK1 H-InvDB: KCNK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCNK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNK1 gene:
    Search GeneIP for patents involving KCNK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNK1
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNK1   OriGene RNAi products in human, mouse, rat for KCNK1  
     OriGene qPCR primer pairs and template standards for KCNK1   OriGene Protein Over-expression Lysate for KCNK1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNK1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNK1   OriGene Custom Protein Services for KCNK1  

     
     
     Block miRNA regulation of human, mouse, rat KCNK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNK1 Predesigned siRNA for gene silencing in human, mouse, rat KCNK1
     QuantiFast Probe-based Assays in human, mouse, rat KCNK1 QuantiTect SYBR Green Assays in human, mouse, rat KCNK1
     PCR Arrays including human, mouse, rat KCNK1 Search Chromatin IP Primers for KCNK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNK1  Search GeneGlobe Interaction Network for KCNK1
     Regulatory tfbs in KCNK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCNK1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNK1
     GenScript Custom Assay Services for KCNK1 GenScript Custom overexpressing Cell Line Services for KCNK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KCNK1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KCNK1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCNK1 antibodies
     KCNK1 proteins
     KCNK1 lysates
     Antibodies for KCNK1
     See all of Abcam's Antibodies, Kits and Proteins for KCNK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KCNK1
     Antibodies for KCNK1
     ELISAs for KCNK1
     CLIAs for KCNK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCNK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNK1
     SwitchGear 3'UTR luciferase reporter plasmids for KCNK1
     SwitchGear Promoter luciferase reporter plasmids for KCNK1
     Search ThermoFisher Antibodies for KCNK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNK1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNK1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNK1
     LSBio Antibodies in human, mouse, rat for KCNK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KCNK1
      Search eBioscience for proteins for KCNK1
      Search eBioscience for elisas for KCNK1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNK1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4