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Aliases for KCNJ9 Gene

Aliases for KCNJ9 Gene

  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 9 2 3
  • GIRK3 3 4 6
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 9 3 4
  • Inward Rectifier K(+) Channel Kir3.3 3 4
  • GIRK-3 3 4
  • G Protein-Activated Inward Rectifier Potassium Channel 3 3
  • G Protein-Coupled Inward Rectifier Potassium Channel 3
  • Inwardly Rectifier K+ Channel KIR3.3 3
  • KIR3.3 3

External Ids for KCNJ9 Gene

Summaries for KCNJ9 Gene

Entrez Gene Summary for KCNJ9 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNJ9 Gene

KCNJ9 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 9) is a Protein Coding gene. Among its related pathways are G-Beta Gamma Signaling and Circadian entrainment. GO annotations related to this gene include G-protein activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ9 Gene

  • This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).

Tocris Summary for KCNJ9 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ9 Gene

Genomics for KCNJ9 Gene

Genomic Location for KCNJ9 Gene

Start:
160,081,561 bp from pter
End:
160,090,563 bp from pter
Size:
9,003 bases
Orientation:
Plus strand

Genomic View for KCNJ9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNJ9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ9 Gene

Regulatory Elements for KCNJ9 Gene

Proteins for KCNJ9 Gene

  • Protein details for KCNJ9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92806-KCNJ9_HUMAN
    Recommended name:
    G protein-activated inward rectifier potassium channel 3
    Protein Accession:
    Q92806
    Secondary Accessions:
    • Q5JW75

    Protein attributes for KCNJ9 Gene

    Size:
    393 amino acids
    Molecular mass:
    44020 Da
    Quaternary structure:
    • Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (By similarity).

neXtProt entry for KCNJ9 Gene

Proteomics data for KCNJ9 Gene at MOPED

Post-translational modifications for KCNJ9 Gene

No Post-translational modifications

Other Protein References for KCNJ9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNJ9 Gene

Domains for KCNJ9 Gene

Gene Families for KCNJ9 Gene

HGNC:
  • KCN :Potassium channels
  • KCNJ :Voltage-gated ion channels / Potassium channels, Inwardly rectifying
IUPHAR :

Suggested Antigen Peptide Sequences for KCNJ9 Gene

Graphical View of Domain Structure for InterPro Entry

Q92806

UniProtKB/Swiss-Prot:

KCNJ9_HUMAN
Domain:
  • The PDZ-binding motif specifically binds the PDZ domain of SNX27: the specificity for SNX27 is provided by the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif.:
    • Q92806
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily.:
    • Q92806
genes like me logo Genes that share domains with KCNJ9: view

Function for KCNJ9 Gene

Molecular function for KCNJ9 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 9,expressed in brain
UniProtKB/Swiss-Prot Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).

Gene Ontology (GO) - Molecular Function for KCNJ9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity --
GO:0005515 protein binding IPI 12297500
GO:0015467 G-protein activated inward rectifier potassium channel activity IBA --
GO:0030165 PDZ domain binding IEA --
genes like me logo Genes that share ontologies with KCNJ9: view

Phenotypes for KCNJ9 Gene

genes like me logo Genes that share phenotypes with KCNJ9: view

Animal Models for KCNJ9 Gene

MGI Knock Outs for KCNJ9:

miRNA for KCNJ9 Gene

miRTarBase miRNAs that target KCNJ9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNJ9 Gene

Localization for KCNJ9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ9 Gene COMPARTMENTS Subcellular localization image for KCNJ9 gene
Compartment Confidence
plasma membrane 4
endosome 1

Gene Ontology (GO) - Cellular Components for KCNJ9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNJ9: view

Pathways for KCNJ9 Gene

genes like me logo Genes that share pathways with KCNJ9: view

Gene Ontology (GO) - Biological Process for KCNJ9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0007268 synaptic transmission TAS --
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IBA --
GO:0071805 potassium ion transmembrane transport --
genes like me logo Genes that share ontologies with KCNJ9: view

Compounds for KCNJ9 Gene

(5) Tocris Compounds for KCNJ9 Gene

Compound Action Cas Number
Diazoxide Blocks desensitization of AMPA receptors [364-98-7]
Glibenclamide Kir6 (KATP) channel blocker [10238-21-8]
Levcromakalim Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377) [94535-50-9]
P1075 Potent Kir6 (KATP) channel opener [60559-98-0]
Tertiapin-Q Selective blocker of inward-rectifier K+ channels [252198-49-5]

(1) HMDB Compounds for KCNJ9 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4

(1) IUPHAR Ligand for KCNJ9 Gene

Ligand Type Action Affinity Pubmed IDs
PIP2 Activator Agonist 5.3

(2) Novoseek inferred chemical compound relationships for KCNJ9 Gene

Compound -log(P) Hits PubMed IDs
potassium 71.7 22
pertussis 63.2 1
genes like me logo Genes that share compounds with KCNJ9: view

Transcripts for KCNJ9 Gene

mRNA/cDNA for KCNJ9 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNJ9 Gene

Potassium inwardly-rectifying channel, subfamily J, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ9 Gene

No ASD Table

Relevant External Links for KCNJ9 Gene

GeneLoc Exon Structure for
KCNJ9
ECgene alternative splicing isoforms for
KCNJ9

Expression for KCNJ9 Gene

mRNA expression in normal human tissues for KCNJ9 Gene

mRNA differential expression in normal tissues according to GTEx for KCNJ9 Gene

This gene is overexpressed in Brain - Cortex (6.1), Brain - Cerebellar Hemisphere (5.6), Brain - Frontal Cortex (BA9) (5.4), Brain - Cerebellum (5.3), and Brain - Anterior cingulate cortex (BA24) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNJ9 Gene

SOURCE GeneReport for Unigene cluster for KCNJ9 Gene Hs.66726

genes like me logo Genes that share expressions with KCNJ9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNJ9 Gene

Orthologs for KCNJ9 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNJ9 35
  • 93.47 (n)
  • 98.47 (a)
KCNJ9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNJ9 35
  • 91.08 (n)
  • 94.37 (a)
KCNJ9 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnj9 35
  • 91.86 (n)
  • 98.73 (a)
Kcnj9 16
Kcnj9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ9 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ9 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj9 35
  • 92.2 (n)
  • 98.98 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia KCNJ9 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KCNJ9 36
  • 73 (a)
OneToOne
LOC100334285 35
  • 73.18 (n)
  • 80.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ir 37
  • 51 (a)
Irk2 37
  • 50 (a)
Irk3 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea irk-2 37
  • 47 (a)
irk-1 37
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for KCNJ9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNJ9 Gene

ENSEMBL:
Gene Tree for KCNJ9 (if available)
TreeFam:
Gene Tree for KCNJ9 (if available)

Paralogs for KCNJ9 Gene

Selected SIMAP similar genes for KCNJ9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNJ9: view

Variants for KCNJ9 Gene

Sequence variations from dbSNP and Humsavar for KCNJ9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2145385 -- 160,081,299(-) CTGGC(A/G)CGCTG upstream-variant-2KB
rs2180752 -- 160,081,123(-) CATCA(C/T)GGTCT upstream-variant-2KB
rs2494211 -- 160,088,822(+) AGGGG(C/T)ACCTG utr-variant-3-prime
rs2737702 -- 160,085,315(+) AAGGA(A/T)GTTGT intron-variant
rs2737703 -- 160,086,142(+) GTGTC(C/T)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ9 Gene

Variant ID Type Subtype PubMed ID
nsv520189 CNV Loss 19592680

Relevant External Links for KCNJ9 Gene

HapMap Linkage Disequilibrium report
KCNJ9
Human Gene Mutation Database (HGMD)
KCNJ9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ9 Gene

Disorders for KCNJ9 Gene

Relevant External Links for KCNJ9

Genetic Association Database (GAD)
KCNJ9
Human Genome Epidemiology (HuGE) Navigator
KCNJ9
genes like me logo Genes that share disorders with KCNJ9: view

No data available for UniProtKB/Swiss-Prot for KCNJ9 Gene

Publications for KCNJ9 Gene

  1. Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). (PMID: 10913335) Vaughn J. … Permana P.A. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. (PMID: 10956667) Jelacic T.M. … Clapham D.E. (J. Biol. Chem. 2000) 3 23
  3. Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. (PMID: 8575783) Lesage F. … MattAci M.G. (Genomics 1995) 2 3
  4. Co-expression of human Kir3 subunits can yield channels with different functional properties. (PMID: 10659995) Schoots O. … Van Tol H.H.M. (Cell. Signal. 1999) 3 4
  5. Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. (PMID: 11350189) Wolford J.K. … Prochazka M. (Mol. Genet. Metab. 2001) 3 48

Products for KCNJ9 Gene

Sources for KCNJ9 Gene

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