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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNJ9 Gene

protein-coding   GIFtS: 61
GCID: GC01P160051

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 91 2     KIR3.32
GIRK32 3 5     G Protein-Activated Inward Rectifier Potassium Channel 32
Inward Rectifier K(+) Channel Kir3.32 3     G Protein-Coupled Inward Rectifier Potassium Channel2
Potassium Channel, Inwardly Rectifying Subfamily J Member 92 3     Inwardly Rectifier K+ Channel KIR3.32
GIRK-32 3     

External Ids:    HGNC: 62701   Entrez Gene: 37652   Ensembl: ENSG000001627287   OMIM: 6009325   UniProtKB: Q928063   

Export aliases for KCNJ9 gene to outside databases

Previous GC identifers: GC01P157843 GC01P155783 GC01P156829 GC01P157268 GC01P156864 GC01P158317 GC01P131408


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ9 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out
of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form
a heteromultimeric pore-forming complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNJ9 Gene: 
KCNJ9 (potassium inwardly-rectifying channel, subfamily J, member 9) is a protein-coding gene. Diseases associated with KCNJ9 include morphine dependence, and idiopathic generalized epilepsy, and among its related super-pathways are Voltage gated Potassium channels and Retrograde endocannabinoid signaling. GO annotations related to this gene include protein binding and G-protein activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a
greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of
the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of
outward current by internal magnesium (By similarity)

summary for KCNJ9 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNJ9 gene promoter:
         STAT5B   Pax-5   GATA-2   HEN1   MZF-1   AREB6   deltaCREB   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ9 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNJ9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

KCNJ9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160051:  view genomic region     (about GC identifiers)

Start:
160,051,360 bp from pter      End:
160,060,353 bp from pter
Size:
8,994 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806 (See protein sequence)
Recommended Name: G protein-activated inward rectifier potassium channel 3  
Size: 393 amino acids; 44020 Da
Subunit: Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via
PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent
degradation in lysosomes and promote recycling to the plasma membrane (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5JW75

Explore the universe of human proteins at neXtProt for KCNJ9: NX_Q92806

Explore proteomics data for KCNJ9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92806

  • KCNJ9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNJ9 Protein Expression
    REFSEQ proteins: NP_004974.2  
    ENSEMBL proteins: 
     ENSP00000357067  
    Reactome Protein details: Q92806
    Human Recombinant Protein Products for KCNJ9: 
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    Cloud-Clone Corp. Proteins for KCNJ9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    KCNJ9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kir3.3 
    Inwardly rectifying potassium channels

    4 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR013518 K_chnl_inward-rec_Kir_cyto
     IPR016449 K_chnl_inward-rec_Kir
     IPR003276 K_chnl_inward-rec_Kir3.3

    Graphical View of Domain Structure for InterPro Entry Q92806

    ProtoNet protein and cluster: Q92806

    2 Blocks protein domains:
    IPB001838 Inward rectifier K+ channel superfamily signature
    IPB003276 Kir3.3 inward rectifier K+ channel signature


    UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806
    Domain: The PDZ-binding motif specifically binds the PDZ domain of SNX27: the specificity for SNX27 is provided by
    the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif (By similarity)
    Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily


    KCNJ9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRK9_HUMAN, Q92806
    Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a
    greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is
    regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of
    the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of
    outward current by internal magnesium (By similarity)

         Genatlas biochemistry entry for KCNJ9:
    potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 9,expressed in brain

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity ----
    GO:0005515protein binding IPI12297500
    GO:0015467G-protein activated inward rectifier potassium channel activity IEA--
         
    KCNJ9 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcnj9):
     behavior/neurological  mortality/aging  nervous system 

    KCNJ9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcnj9tm1Kwn for KCNJ9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNJ9 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNJ9 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    2Circadian entrainment
    Morphine addiction0.53
    Dopaminergic synapse0.37
    Retrograde endocannabinoid signaling0.51
    Serotonergic synapse0.33
    Circadian entrainment0.40
    3Inwardly rectifying K+ channels
    G protein gated Potassium channels0.81
    Activation of G protein gated Potassium channels0.81
    Inwardly rectifying K+ channels0.81
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.81
    4Activation of GABAB receptors
    Activation of GABAB receptors0.72
    GABA B receptor activation0.72
    GABA receptor activation0.72
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for KCNJ9
        Potassium transporters- inward current
    Synaptic transmission- ion currents
    Potassium transporters- outward current

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNJ9
        G-Beta Gamma Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    5/11        Reactome Pathways for KCNJ9 (see all 11)
        Transmission across Chemical Synapses
    G protein gated Potassium channels
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
    Inwardly rectifying K+ channels


    5/6         Kegg Pathways  (Kegg details for KCNJ9) (see all 6):
        Circadian entrainment
    Retrograde endocannabinoid signaling
    Serotonergic synapse
    Dopaminergic synapse
    Estrogen signaling pathway


    KCNJ9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNJ9

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KCNJ9 (Q928063 ENSP000003570674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD4P219173, ENSP000001761834I2D: score=2 STRING: ENSP00000176183
    KCNJ6P480513, ENSP000003833304I2D: score=2 STRING: ENSP00000383330
    ADRB2P075503, ENSP000003053724I2D: score=1 STRING: ENSP00000305372
    KCNJ3P485493, ENSP000002951014I2D: score=1 STRING: ENSP00000295101
    DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport ----
    GO:0007268synaptic transmission TAS--

    KCNJ9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNJ9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNJ9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
    DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
    GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
    P1075Potent Kir6 (KATP) channel opener[60559-98-0]
    Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

    1 HMDB Compound for KCNJ9    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 IUPHAR Ligand for KCNJ9 (Kir3.3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    PIP2
    ActivatorNone--

    2 Novoseek inferred chemical compound relationships for KCNJ9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 71.7 27 12718857 (2), 8733729 (1), 8567663 (1), 10913335 (1) (see all 21)
    pertussis 63.2 1 16950155 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNJ9 / IRK9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for KCNJ9 gene: 
    NM_004983.2  

    Unigene Cluster for KCNJ9:

    Potassium inwardly-rectifying channel, subfamily J, member 9
    Hs.66726  [show with all ESTs]
    Unigene Representative Sequence: U52152
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368088(uc001fux.1 uc009wte.1 uc001fuy.1)
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    Additional mRNA sequence: 

    BC111535.1 BC117516.1 BC117517.1 BC117518.1 BC117519.1 U52152.1 

    2 DOTS entries:

    DT.106188  DT.99982009 

    6 AceView cDNA sequences:

    NM_004983 M78658 BG911966 M78659 U52152 BP361216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNJ9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNJ9 Expression
    About this image


    See KCNJ9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNJ9

    SOURCE GeneReport for Unigene cluster: Hs.66726
        SABiosciences Expression via Pathway-Focused PCR Array including KCNJ9: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KCNJ9 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnj91 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 91.86(n)1
    98.73(a)1
      1 (79.66 cM)5
    165241  NM_008429.21  NP_032455.21 
     1723210335 
    lizard
    (Anolis carolinensis)
    Reptilia KCNJ96
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL344012.1(50317-58063)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003342851 g protein-activated inward rectifier potassium channel more 70.93(n)
    77.07(a)
      100334285  XM_002660902.1  XP_002660948.1 


    ENSEMBL Gene Tree for KCNJ9 (if available)
    TreeFam Gene Tree for KCNJ9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNJ9 gene
    KCNJ42  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ152  KCNJ52  KCNJ62  
    KCNJ22  KCNJ102  KCNJ142  KCNJ32  KCNJ112  
    16 SIMAP similar genes for KCNJ9 using alignment to 1 protein entry:     IRK9_HUMAN:
    KCNJ6    KCNJ5    KCNJ3    KCNJ2    KCNJ11    KCNJ12
    KCNJ18    kcnj12x    KCNJ8    KCNJ15    KCNJ1    KCNJ14
    KCNJ4    KCNJ10    KCNJ16    KCNJ13

    KCNJ9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 SNPs in KCNJ9 are shown (see all 185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175845171,2
    F--160049403(+) GGCTAA/GGGCTG 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1481246651,2
    --160049457(+) AATTCA/GTGGCT 1 -- us2k10--------
    rs1159429591,2
    C,F--160049543(+) CATACG/TATCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1418392551,2
    --160049561(+) TGCTCC/TTTGGT 1 -- us2k10--------
    rs1153350451,2
    F--160049613(+) CTGCCG/AATGGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1832649271,2
    --160049615(+) GCCGAC/TGGATG 1 -- us2k10--------
    rs112653161,2
    F--160049622(+) GATGTT/CTATAG 1 -- us2k13Minor allele frequency- C:0.17NA CSA 6
    rs1863792801,2
    --160049662(+) AAGCAA/GCCGAG 1 -- us2k10--------
    rs1170030591,2
    F--160049663(+) AGCAAC/TCGAGA 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1393084181,2
    --160049808(+) GAAGCC/TAATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNJ9 (160051360 - 160060353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KCNJ9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520189CNV Loss19592680


    Human Gene Mutation Database (HGMD): KCNJ9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNJ9
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600932    OMIM disorders: --

    10 diseases for KCNJ9:    About MalaCards
    morphine dependence    idiopathic generalized epilepsy    meniere's disease    menieres disease
    pertussis    migraine    diabetes mellitus    schizophrenia
    lung cancer    neuronitis


    KCNJ9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNJ9
    Human Genome Epidemiology (HuGE) Navigator: KCNJ9 (6 documents)

    Export disorders for KCNJ9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNJ9 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with KCNJ9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). (PubMed id 10913335)1, 2, 9 Vaughn J.... Permana P.A. (2000)
    2. Association analysis of chromosome 1 migraine candidate genes. (PubMed id 17727731)1, 4 Fernandez F....Griffiths L.R. (2007)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. (PubMed id 15911117)1, 4 Lohoff F.W....Buono R.J. (2005)
    5. International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
    6. Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. (PubMed id 11350189)1, 4 Wolford J.K....Prochazka M. (2001)
    7. Co-expression of human Kir3 subunits can yield channels with different functional properties. (PubMed id 10659995)1, 2 Schoots O....Van Tol H.H.M. (1999)
    8. Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. (PubMed id 8575783)1, 3 Lesage F....Mattei M.G. (1995)
    9. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. (PubMed id 10956667)1, 9 Jelacic T.M....Clapham D.E. (2000)
    10. Identification of GIRK2-4 subunits in human esophagea l smooth muscle cells. (PubMed id 21637918)1 Lu Q....Han Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3765 HGNC: 6270 AceView: KCNJ9 Ensembl:ENSG00000162728 euGenes: HUgn3765
    ECgene: KCNJ9 Kegg: 3765 H-InvDB: KCNJ9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNJ9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNJ9 gene:
    Search GeneIP for patents involving KCNJ9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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