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KCNJ9 Gene

protein-coding   GIFtS: 60
GCID: GC01P160051

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 91 2     KIR3.32
GIRK32 3 5     G Protein-Activated Inward Rectifier Potassium Channel 32
Inward Rectifier K(+) Channel Kir3.32 3     G Protein-Coupled Inward Rectifier Potassium Channel2
Potassium Channel, Inwardly Rectifying Subfamily J Member 92 3     Inwardly Rectifier K+ Channel KIR3.32
GIRK-32 3     

External Ids:    HGNC: 62701   Entrez Gene: 37652   Ensembl: ENSG000001627287   OMIM: 6009325   UniProtKB: Q928063   

Export aliases for KCNJ9 gene to outside databases

Previous GC identifers: GC01P157843 GC01P155783 GC01P156829 GC01P157268 GC01P156864 GC01P158317 GC01P131408


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNJ9 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out
of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form
a heteromultimeric pore-forming complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNJ9 Gene:
KCNJ9 (potassium inwardly-rectifying channel, subfamily J, member 9) is a protein-coding gene. Diseases associated with KCNJ9 include morphine dependence, and meniere's disease. GO annotations related to this gene include G-protein activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a
greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of
the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of
outward current by internal magnesium (By similarity)

summary for KCNJ9 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNJ9 gene promoter:
         STAT5B   Pax-5   GATA-2   HEN1   MZF-1   AREB6   deltaCREB   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ9 promoter sequence
   Search Chromatin IP Primers for KCNJ9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNJ9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

KCNJ9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160051:  view genomic region     (about GC identifiers)

Start:
160,051,360 bp from pter      End:
160,060,353 bp from pter
Size:
8,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806 (See protein sequence)
Recommended Name: G protein-activated inward rectifier potassium channel 3  
Size: 393 amino acids; 44020 Da
Subunit: Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via
PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent
degradation in lysosomes and promote recycling to the plasma membrane (By similarity)
Secondary accessions: Q5JW75

Explore the universe of human proteins at neXtProt for KCNJ9: NX_Q92806

Explore proteomics data for KCNJ9 at MOPED


See KCNJ9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004974.2  
ENSEMBL proteins: 
 ENSP00000357067  
Reactome Protein details: Q92806

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
KCN: Potassium channels
KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

IUPHAR Guide to PHARMACOLOGY protein family classification: Kir3.3
Inwardly rectifying potassium channels

4 InterPro protein domains:
 IPR014756 Ig_E-set
 IPR013518 K_chnl_inward-rec_Kir_cyto
 IPR016449 K_chnl_inward-rec_Kir
 IPR003276 K_chnl_inward-rec_Kir3.3

Graphical View of Domain Structure for InterPro Entry Q92806

ProtoNet protein and cluster: Q92806

2 Blocks protein domains:
IPB001838 Inward rectifier K+ channel superfamily signature
IPB003276 Kir3.3 inward rectifier K+ channel signature


UniProtKB/Swiss-Prot: IRK9_HUMAN, Q92806
Domain: The PDZ-binding motif specifically binds the PDZ domain of SNX27: the specificity for SNX27 is provided by
the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif (By similarity)
Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily


KCNJ9 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IRK9_HUMAN, Q92806
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a
greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of
the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of
outward current by internal magnesium (By similarity)

     Genatlas biochemistry entry for KCNJ9:
potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 9,expressed in brain

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005242inward rectifier potassium channel activity ----
GO:0005515protein binding IPI12297500
GO:0015467G-protein activated inward rectifier potassium channel activity IEA--
GO:0030165PDZ domain binding IEA--
     
KCNJ9 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kcnj9):
 behavior/neurological  mortality/aging  nervous system 

KCNJ9 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Kcnj9tm1Kwn for KCNJ9

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNJ9
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miRNA
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miRTarBase miRNAs that target KCNJ9:
hsa-mir-335-5p (MIRT017196), hsa-mir-132-3p (MIRT021726)

Block miRNA regulation of human, mouse, rat KCNJ9 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate KCNJ9:
hsa-miR-661 hsa-miR-1231 hsa-miR-493
SwitchGear 3'UTR luciferase reporter plasmidKCNJ9 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IRK9_HUMAN, Q92806: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
endosome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

KCNJ9 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KCNJ9 About   (see all 11)  
See pathways by source

SuperPathContained pathways About
1Potassium Channels
Potassium Channels0.43
Potassium transporters outward current0.41
2Circadian entrainment
Morphine addiction0.53
Dopaminergic synapse0.37
Retrograde endocannabinoid signaling0.51
Serotonergic synapse0.33
Circadian entrainment0.40
3Inwardly rectifying K+ channels
Inwardly rectifying K+ channels0.82
G protein gated Potassium channels0.82
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.82
Activation of G protein gated Potassium channels0.82
4GABA receptor activation
GABA B receptor activation0.73
GABA receptor activation0.73
Activation of GABAB receptors0.73
5Transmission across Chemical Synapses
Transmission across Chemical Synapses0.72
Neuronal System0.68
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNJ9
    G-Beta Gamma Signaling
Dopamine-DARPP32 Feedback onto cAMP Pathway

2 Reactome Pathways for KCNJ9
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Activation of G protein gated Potassium channels


Selected Kegg Pathways  (Kegg details for KCNJ9) (see all 7):
    Circadian entrainment
Retrograde endocannabinoid signaling
Serotonergic synapse
Dopaminergic synapse
Estrogen signaling pathway


KCNJ9 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ9: 
          Neuronal Ion Channels in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for KCNJ9

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for KCNJ9 (Q928063 ENSP000003570674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
DRD4P219173, ENSP000001761834I2D: score=2 STRING: ENSP00000176183
ADRB2P075503, ENSP000003053724I2D: score=1 STRING: ENSP00000305372
KCNJ3P485493, ENSP000002951014I2D: score=1 STRING: ENSP00000295101
DRD2P144163, ENSP000003548594I2D: score=1 STRING: ENSP00000354859
KCNJ6P480513I2D: score=2 
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006813potassium ion transport ----
GO:0007268synaptic transmission TAS--

KCNJ9 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for KCNJ9 available from Tocris Bioscience    About this table
CompoundAction CAS #
LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
P1075Potent Kir6 (KATP) channel opener[60559-98-0]
Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

1 HMDB Compound for KCNJ9    About this table
CompoundSynonyms CAS #PubMed Ids
MagnesiumMagnesium (see all 2)7439-95-4--

1 IUPHAR Ligand for KCNJ9 (Kir3.3)    About this table
LigandTypeActionAffinityPubmed IDs
PIP2
ActivatorNone--

2 Novoseek inferred chemical compound relationships for KCNJ9 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
potassium 71.7 27 12718857 (2), 8733729 (1), 8567663 (1), 10913335 (1) (see all 21)
pertussis 63.2 1 16950155 (1)



KCNJ9 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KCNJ9 gene: 
NM_004983.2  

Unigene Cluster for KCNJ9:

Potassium inwardly-rectifying channel, subfamily J, member 9
Hs.66726  [show with all ESTs]
Unigene Representative Sequence: U52152
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000368088(uc001fux.1 uc009wte.1 uc001fuy.1)
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SwitchGear 3'UTR luciferase reporter plasmidKCNJ9 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat KCNJ9

Additional mRNA sequence: 

BC111535.1 BC117516.1 BC117517.1 BC117518.1 BC117519.1 U52152.1 

2 DOTS entries:

DT.106188  DT.99982009 

6 AceView cDNA sequences:

NM_004983 U52152 BG911966 M78659 M78658 BP361216 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNJ9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KCNJ9 Expression
About this image

KCNJ9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KCNJ9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.66726
    Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ9: 
          Neuronal Ion Channels in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KCNJ9 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcnj91 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 91.86(n)1
98.73(a)1
  1 (79.66 cM)5
165241  NM_008429.21  NP_032455.21 
 1723210335 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
49(a)
many ↔ many
27(3239714-3247916)
lizard
(Anolis carolinensis)
Reptilia KCNJ96
potassium inwardly-rectifying channel, subfamily J...
78(a)
1 ↔ 1
GL344012.1(50317-58063)
zebrafish
(Danio rerio)
Actinopterygii LOC1003342851 g protein-activated inward rectifier potassium channel more 73.18(n)
80.76(a)
  100334285  XM_002660902.2  XP_002660948.1 


ENSEMBL Gene Tree for KCNJ9 (if available)
TreeFam Gene Tree for KCNJ9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KCNJ9 gene
KCNJ42  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ152  KCNJ52  KCNJ62  
KCNJ22  KCNJ102  KCNJ142  KCNJ32  KCNJ112  
16 SIMAP similar genes for KCNJ9 using alignment to 1 protein entry:     IRK9_HUMAN:
KCNJ6    KCNJ5    KCNJ3    KCNJ2    KCNJ11    KCNJ12
KCNJ18    kcnj12x    KCNJ8    KCNJ15    KCNJ1    KCNJ14
KCNJ4    KCNJ10    KCNJ16    KCNJ13

KCNJ9 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCNJ9 (see all 185)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1175845171,2
F--160049403(+) GGCTAA/GGGCTG 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs1481246651,2
--160049457(+) AATTCA/GTGGCT 1 -- us2k10--------
rs1159429591,2
C,F--160049543(+) CATACG/TATCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1418392551,2
--160049561(+) TGCTCC/TTTGGT 1 -- us2k10--------
rs1153350451,2
F--160049613(+) CTGCCG/AATGGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs1832649271,2
--160049615(+) GCCGAC/TGGATG 1 -- us2k10--------
rs112653161,2
F--160049622(+) GATGTT/CTATAG 1 -- us2k13Minor allele frequency- C:0.17NA CSA 6
rs1863792801,2
--160049662(+) AAGCAA/GCCGAG 1 -- us2k10--------
rs1170030591,2
F--160049663(+) AGCAAC/TCGAGA 1 -- us2k11Minor allele frequency- T:0.01EA 120
rs1393084181,2
--160049808(+) GAAGCC/TAATTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for KCNJ9 (160051360 - 160060353 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for KCNJ9:    About this table    
Variant IDTypeSubtypePubMed ID
nsv520189CNV Loss19592680

Human Gene Mutation Database (HGMD): KCNJ9
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KCNJ9
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600932    OMIM disorders: --

11 diseases for KCNJ9:    
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morphine dependence    meniere's disease    menieres disease    idiopathic generalized epilepsy
pertussis    migraine    diabetes mellitus    schizophrenia
lung cancer    esophagitis    neuronitis


KCNJ9 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNJ9
Human Genome Epidemiology (HuGE) Navigator: KCNJ9 (6 documents)

Export disorders for KCNJ9 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCNJ9 gene, integrated from 10 sources (see all 37):
(articles sorted by number of sources associating them with KCNJ9)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). (PubMed id 10913335)1, 2, 9 Vaughn J.... Permana P.A. (Biochem. Biophys. Res. Commun. 2000)
  2. Association analysis of chromosome 1 migraine candidate genes. (PubMed id 17727731)1, 4 Fernandez F....Griffiths L.R. (BMC Med. Genet. 2007)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy. (PubMed id 15911117)1, 4 Lohoff F.W....Buono R.J. (Neurosci. Lett. 2005)
  5. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (Pharmacol. Rev. 2005)
  6. Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. (PubMed id 11350189)1, 4 Wolford J.K....Prochazka M. (Mol. Genet. Metab. 2001)
  7. Co-expression of human Kir3 subunits can yield channels with different functional properties. (PubMed id 10659995)1, 2 Schoots O....Van Tol H.H.M. (Cell. Signal. 1999)
  8. Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. (PubMed id 8575783)1, 3 Lesage F....MattAci M.G. (Genomics 1995)
  9. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. (PubMed id 10956667)1, 9 Jelacic T.M....Clapham D.E. (J. Biol. Chem. 2000)
  10. Identification of GIRK2-4 subunits in human esophageal smooth muscle cells. (PubMed id 21637918)1 Lu Q....Han Y. (Mol Med Rep 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3765 HGNC: 6270 AceView: KCNJ9 Ensembl:ENSG00000162728 euGenes: HUgn3765
ECgene: KCNJ9 Kegg: 3765 H-InvDB: KCNJ9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNJ9 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNJ9 gene:
Search GeneIP for patents involving KCNJ9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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