Aliases for KCNJ5 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 5 2 3 5
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 2 3
- Heart KATP Channel 3 4
- IRK-4 3 4
- GIRK4 3 4
- CIR 3 4
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 5 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 5 4
- G Protein-Activated Inward Rectifier Potassium Channel 4 3
- Cardiac ATP-Sensitive Potassium Channel 3
External Ids for KCNJ5 Gene
Previous GeneCards Identifiers for KCNJ5 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNJ5 Gene
KCNJ5 (Potassium Voltage-Gated Channel Subfamily J Member 5) is a Protein Coding gene. Diseases associated with KCNJ5 include Hyperaldosteronism, Familial, Type Iii and Long Qt Syndrome 13. Among its related pathways are Circadian entrainment and Potassium Channels. GO annotations related to this gene include inward rectifier potassium channel activity and G-protein activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ6.
UniProtKB/Swiss-Prot for KCNJ5 Gene
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.