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Aliases for KCNJ4 Gene

Aliases for KCNJ4 Gene

  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 4 2 3
  • HIR 3 4 6
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 4 3 4
  • Inward Rectifier K(+) Channel Kir2.3 3 4
  • HIRK2 3 4
  • IRK-3 3 4
  • HRK1 3 4
  • IRK3 3 4
  • Hippocampal Inward Rectifier Potassium Channel 3
  • Inward Rectifier Potassium Channel 4 3
  • Inward Rectifier K+ Channel Kir2.3 3
  • Hippocampal Inward Rectifier 4
  • Kir2.3 3

External Ids for KCNJ4 Gene

Summaries for KCNJ4 Gene

Entrez Gene Summary for KCNJ4 Gene

  • Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNJ4 Gene

KCNJ4 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 4) is a Protein Coding gene. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. GO annotations related to this gene include PDZ domain binding and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ4 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

Tocris Summary for KCNJ4 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ4 Gene

Genomics for KCNJ4 Gene

Genomic Location for KCNJ4 Gene

Start:
38,426,327 bp from pter
End:
38,455,199 bp from pter
Size:
28,873 bases
Orientation:
Minus strand

Genomic View for KCNJ4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNJ4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ4 Gene

Regulatory Elements for KCNJ4 Gene

Proteins for KCNJ4 Gene

  • Protein details for KCNJ4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48050-KCNJ4_HUMAN
    Recommended name:
    Inward rectifier potassium channel 4
    Protein Accession:
    P48050
    Secondary Accessions:
    • Q14D44

    Protein attributes for KCNJ4 Gene

    Size:
    445 amino acids
    Molecular mass:
    49500 Da
    Quaternary structure:
    • Homomultimeric and heteromultimeric association with KCNJ2 and KCNJ12. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members for KCNJ4 binding.

    Three dimensional structures from OCA and Proteopedia for KCNJ4 Gene

neXtProt entry for KCNJ4 Gene

Proteomics data for KCNJ4 Gene at MOPED

Post-translational modifications for KCNJ4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNJ4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNJ4 Gene

Domains for KCNJ4 Gene

Gene Families for KCNJ4 Gene

HGNC:
  • KCN :Potassium channels
  • KCNJ :Voltage-gated ion channels / Potassium channels, Inwardly rectifying
IUPHAR :

Suggested Antigen Peptide Sequences for KCNJ4 Gene

Graphical View of Domain Structure for InterPro Entry

P48050

UniProtKB/Swiss-Prot:

KCNJ4_HUMAN
Domain:
  • The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties:
    • P48050
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.:
    • P48050
genes like me logo Genes that share domains with KCNJ4: view

Function for KCNJ4 Gene

Molecular function for KCNJ4 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel,inwardly rectifying,expressed in heart
UniProtKB/Swiss-Prot Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

Gene Ontology (GO) - Molecular Function for KCNJ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity IEA --
GO:0005515 protein binding IPI 16855024
GO:0030165 PDZ domain binding IPI 16855024
genes like me logo Genes that share ontologies with KCNJ4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNJ4 Gene

Localization for KCNJ4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ4 Gene COMPARTMENTS Subcellular localization image for KCNJ4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNJ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 8051145
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IDA 16855024
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with KCNJ4: view

Pathways for KCNJ4 Gene

genes like me logo Genes that share pathways with KCNJ4: view

Gene Ontology (GO) - Biological Process for KCNJ4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 8051145
GO:0007268 synaptic transmission TAS --
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IBA --
GO:0071805 potassium ion transmembrane transport --
genes like me logo Genes that share ontologies with KCNJ4: view

Compounds for KCNJ4 Gene

(5) Tocris Compounds for KCNJ4 Gene

Compound Action Cas Number
Diazoxide Blocks desensitization of AMPA receptors [364-98-7]
Glibenclamide Kir6 (KATP) channel blocker [10238-21-8]
Levcromakalim Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377) [94535-50-9]
P1075 Potent Kir6 (KATP) channel opener [60559-98-0]
Tertiapin-Q Selective blocker of inward-rectifier K+ channels [252198-49-5]

(1) HMDB Compounds for KCNJ4 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4

(13) IUPHAR Ligand for KCNJ4 Gene

Ligand Type Action Affinity Pubmed IDs
SCH-23390 Antagonist Antagonist 9.5
H+ (intracellular) Gating inhibitor Antagonist 6.77
tenidap Activator Agonist 6.4
Zn2+ Channel blocker None 6
H+ (extracellular) Activator None 5.4
spermine Channel blocker None 4.43
Cs+ Pore Blocker Antagonist 3.8
arachidonic acid Activator Potentiation
Mg2+ Antagonist Antagonist
Ba2+ Pore Blocker Antagonist
tetraethylammonium Inhibitor None
spermidine Pore Blocker Antagonist
putrescine Pore Blocker Antagonist

(6) Novoseek inferred chemical compound relationships for KCNJ4 Gene

Compound -log(P) Hits PubMed IDs
petn 66.2 2
potassium 46.3 4
tyrosine 44.6 4
phosphatidylinositol 28.2 1
alanine 17.1 3
genes like me logo Genes that share compounds with KCNJ4: view

Transcripts for KCNJ4 Gene

mRNA/cDNA for KCNJ4 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNJ4 Gene

Potassium inwardly-rectifying channel, subfamily J, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ4 Gene

No ASD Table

Relevant External Links for KCNJ4 Gene

GeneLoc Exon Structure for
KCNJ4
ECgene alternative splicing isoforms for
KCNJ4

Expression for KCNJ4 Gene

mRNA expression in normal human tissues for KCNJ4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNJ4 Gene

This gene is overexpressed in Brain - Cortex (9.2), Brain - Frontal Cortex (BA9) (7.7), Brain - Anterior cingulate cortex (BA24) (5.9), Brain - Putamen (basal ganglia) (5.2), and Brain - Nucleus accumbens (basal ganglia) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNJ4 Gene

SOURCE GeneReport for Unigene cluster for KCNJ4 Gene Hs.32505

mRNA Expression by UniProt/SwissProt for KCNJ4 Gene

P48050-KCNJ4_HUMAN
Tissue specificity: Heart, skeletal muscle, and several different brain regions including the hippocampus
genes like me logo Genes that share expressions with KCNJ4: view

Orthologs for KCNJ4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ4 35
  • 99.55 (n)
  • 100 (a)
KCNJ4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNJ4 35
  • 94.08 (n)
  • 96.63 (a)
KCNJ4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnj4 35
  • 89.56 (n)
  • 97.3 (a)
Kcnj4 16
Kcnj4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj4 35
  • 90.34 (n)
  • 97.53 (a)
chicken
(Gallus gallus)
Aves CKIR2.3 36
  • 84 (a)
OneToOne
KCNJ4 35
  • 80.97 (n)
  • 86.79 (a)
lizard
(Anolis carolinensis)
Reptilia KCNJ4 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj4 35
  • 71.55 (n)
  • 83.87 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNJ4 36
  • 59 (a)
OneToOne
LOC100331864 35
  • 66.67 (n)
  • 62.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ir 37
  • 51 (a)
Irk2 37
  • 49 (a)
Irk3 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea irk-1 36
  • 32 (a)
ManyToMany
irk-2 36
  • 39 (a)
ManyToMany
irk-2 37
  • 47 (a)
irk-1 37
  • 48 (a)
Species with no ortholog for KCNJ4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNJ4 Gene

ENSEMBL:
Gene Tree for KCNJ4 (if available)
TreeFam:
Gene Tree for KCNJ4 (if available)

Paralogs for KCNJ4 Gene

Selected SIMAP similar genes for KCNJ4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNJ4: view

Variants for KCNJ4 Gene

Sequence variations from dbSNP and Humsavar for KCNJ4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs46629 -- 38,451,644(-) CTCTA(C/T)CTGGA intron-variant
rs169032 -- 38,456,899(-) CACGA(A/G)GAAGG upstream-variant-2KB
rs196060 -- 38,428,628(-) TAGTG(C/T)ACAGG intron-variant
rs196061 -- 38,429,103(+) AAAAA(A/G)AAAGA intron-variant
rs196062 -- 38,430,390(-) AGTAG(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ4 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV Loss 17160897
nsv915063 CNV Loss 21882294
dgv4970n71 CNV Loss 21882294
nsv817994 CNV Gain 17921354
nsv819157 CNV Gain 19587683
nsv915066 CNV Loss 21882294

Relevant External Links for KCNJ4 Gene

HapMap Linkage Disequilibrium report
KCNJ4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ4 Gene

Disorders for KCNJ4 Gene

(1) Novoseek inferred disease relationships for KCNJ4 Gene

Disease -log(P) Hits PubMed IDs
hyperglycemia 12.2 1

Relevant External Links for KCNJ4

Genetic Association Database (GAD)
KCNJ4
Human Genome Epidemiology (HuGE) Navigator
KCNJ4
genes like me logo Genes that share disorders with KCNJ4: view

No data available for UniProtKB/Swiss-Prot for KCNJ4 Gene

Publications for KCNJ4 Gene

  1. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. (PMID: 8016146) Perier F. … Vandenberg C.A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. (PMID: 8943291) Cohen N.A. … Nichols C.G. (J. Biol. Chem. 1996) 3 23
  3. Direct activation of an inwardly rectifying potassium channel by arachidonic acid. (PMID: 11306688) Liu Y. … Curran M.E. (Mol. Pharmacol. 2001) 3 23
  4. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PMID: 15958527) Fang Y. … Levitan I. (Am. J. Physiol., Cell Physiol. 2005) 3 23
  5. Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3. (PMID: 18453743) Ureche O.N. … Seebohm G. (Cell. Physiol. Biochem. 2008) 3 23

Products for KCNJ4 Gene

Sources for KCNJ4 Gene

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