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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNJ4 Gene

protein-coding GIFtS: 61
GCID: GC22M038822

potassium inwardly-rectifying channel, subfamily J, member...

Explore 5 diseases affiliated with
KCNJ4 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4¹ ²		HIRK2² ³
HIR¹ ² ³ ⁵		IRK-3² ³
HRK1¹ ² ³		HIRK2² ³
IRK3¹ ² ³		Hippocampal Inward Rectifier Potassium Channel²
Kir2.3¹ ²		Inward Rectifier K+ Channel Kir2.3²
Inward Rectifier K(+) Channel Kir2.3² ³		Inward Rectifier Potassium Channel 4²
Potassium Channel, Inwardly Rectifying Subfamily J Member 4² ³		Hippocampal Inward Rectifier³

External Ids:	HGNC: 6265¹	Entrez Gene: 3761²	Ensembl: ENSG00000168135⁷	OMIM: 600504⁵	UniProtKB: P48050³

Export aliases for KCNJ4 gene to outside databases

Previous GC identifers: GC22M035436 GC22M037065 GC22M037146 GC22M021788

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ4:

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One

class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying

K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This

asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein

encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The

encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript

variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRK4_HUMAN, P48050

Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater

tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the

concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening

shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by

internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)

summary for KCNJ4:

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong

inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the

ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the

pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two

membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each

subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within

subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNJ4 gene promoter:
Max1 AP-1 ATF-2 c-Jun c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNJ4 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNJ4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

KCNJ4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ4 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M038822: view genomic region (about GC identifiers)

Start:	38,822,332 bp from pter	End:	38,851,205 bp from pter
Size:	28,874 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRK4_HUMAN, P48050 (See protein sequence)

Recommended Name: Inward rectifier potassium channel 4

Size: 445 amino acids; 49500 Da

Subunit: Homomultimeric and heteromultimeric association with Kir2.1, resulting in an enhanced G-protein-induced

current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role

in its localization and trafficking (By similarity). Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members

for KCNJ4 binding

Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane (By similarity).

Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization (By similarity)

1 PDB 3D structure from and Proteopedia for KCNJ4:

3GJ9 (3D)

Secondary accessions: Q14D44

Explore the universe of human proteins at neXtProt for KCNJ4: NX_P48050

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48050

KCNJ4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004972.1 NP_690607.1

ENSEMBL proteins:

ENSP00000306497

Reactome Protein details: P48050
Human Recombinant Protein Products for KCNJ4:

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	Uscn Proteins for KCNJ4

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	TAS	8051145
GO:0016323	basolateral plasma membrane	IDA	16855024
GO:0030425	dendrite	--	--
GO:0030659	cytoplasmic vesicle membrane	IEA	--

KCNJ4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNJ4 for domains About GeneDecksing

4 InterPro domains/families:

IPR014756 Ig_E-set

IPR013518 K_chnl_inward-rec_Kir_cyto

IPR003273 K_chnl_inward-rec_Kir2.3

IPR016449 K_chnl_inward-rec_Kir

Graphical View of Domain Structure for InterPro Entry P48050

ProtoNet protein and cluster: P48050

2 Blocks protein families:

IPB001838 Inward rectifier K+ channel superfamily signature

IPB003273 Kir2.3 inward rectifier K+ channel signature

UniProtKB/Swiss-Prot: IRK4_HUMAN, P48050

Domain: The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties

Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IRK4_HUMAN, P48050

Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater

tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the

concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening

shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by

internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)

Genatlas biochemistry entry for KCNJ4:

potassium non voltage-gated channel,inwardly rectifying,expressed in heart

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005242	inward rectifier potassium channel activity	IEA	--
GO:0005515	protein binding	IPI	16855024
GO:0030165	PDZ domain binding	IPI	16855024

KCNJ4 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Inwardly rectifying K+ channels

	Inwardly rectifying K+ channels	1.00			G protein gated Potassium channels	0.81
	Activation of G protein gated Potassium channels	0.81			Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.81

Activation of GABAB receptors

	Activation of GABAB receptors	1.00			GABA receptor activation	0.72
	GABA B receptor activation	1.00

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Potassium Channels

Potassium Channels

1.00

Potassium transporters: outward current

0.42

Classical Kir channels

Classical Kir channels

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for KCNJ4

	Potassium transporters- inward current
	Potassium transporters- outward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ4

Dopamine-DARPP32 Feedback onto cAMP Pathway

5/12 Reactome Pathways for KCNJ4 (see all 12)

	Classical Kir channels
	Transmission across Chemical Synapses
	G protein gated Potassium channels
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

1 PharmGKB Pathway for KCNJ4

Antiarrhythmic Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for KCNJ4):

Cholinergic synapse

KCNJ4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNJ4

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/16 Interacting proteins for KCNJ4 (P48050^{2, 3} ENSP00000306497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LIN7B	Q9HAP6²^,³, ENSP00000221459⁴	MINT-60066 MINT-60068 MINT-60067 I2D: score=3 STRING: ENSP00000221459
CASK	O14936³, ENSP00000367408⁴	I2D: score=4 STRING: ENSP00000367408
DLG4	P78352³, ENSP00000293813⁴	I2D: score=4 STRING: ENSP00000293813
IL16	Q14005³, ENSP00000302935⁴	I2D: score=4 STRING: ENSP00000302935
DLG1	Q12959³, ENSP00000345731⁴	I2D: score=2 STRING: ENSP00000345731

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	8051145
GO:0007268	synaptic transmission	TAS	--

KCNJ4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNJ4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNJ4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Tenidap	NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3	[120210-48-2]
Tertiapin-Q	Selective blocker of inward-rectifier K+ channels	[252198-49-5]

1 HMDB Compound for KCNJ4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

6 Novoseek chemical compound relationships for KCNJ4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
petn	66.2	4	2188977 (1), 7702578 (1)
potassium	46.3	4	7607694 (1), 8016146 (1), 9284339 (1), 8943291 (1)
tyrosine	44.6	5	7537496 (1), 17344070 (1), 7980420 (1), 8163187 (1)
phosphatidylinositol	28.2	1	16787147 (1)
alanine	17.1	3	9345301 (1), 7980420 (1), 7702578 (1)
serine	0	6	9345301 (3), 8201967 (2)

Search CenterWatch for drugs/clinical trials and news about KCNJ4 / IRK4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNJ4 gene (2 alternative transcripts):

NM_004981.1 NM_152868.2

Unigene Cluster for KCNJ4:

Potassium inwardly-rectifying channel, subfamily J, member 4

Hs.32505 [show with all ESTs]

Unigene Representative Sequence: NM_152868

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303592(uc003avs.1 uc003avt.1)

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Additional cDNA sequence:

BC032562.1 BC039618.1 BC113506.1 BC113508.1 CR456507.1 S72503.1 U07364.1 U24056.1

2 DOTS entries:

DT.111327 DT.100735593

24/37 AceView cDNA sequences (see all 37):

NM_152868 U07364 NM_004981 BE222706 H23949 AW590968 BV191061 AI369228

BF739764 BC032562 AI919457 BV189632 CR456507 S72503 BM475496 BM928219

AI569271 BI550775 BC039618 BE222868 H29912 H23948 BF514771 AA904728

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNJ4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTCTTTT

About this image

KCNJ4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lateral Plate Mesoderm

Splanchnic Mesoderm

Pericytes

Pericytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

See KCNJ4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ4

SOURCE GeneReport for Unigene cluster: Hs.32505

UniProtKB/Swiss-Prot: IRK4_HUMAN, P48050

Tissue specificity: Heart, skeletal muscle, and several different brain regions including the hippocampus

SABiosciences Expression via Pathway-Focused PCR Array including KCNJ4:

Neuronal Ion Channels in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNJ4 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNJ4¹	potassium inwardly-rectifying channel, subfamily J, more	82.31(n) 88.68(a)		395903 XM_416263.3 XP_416263.3
lizard (Anolis carolinensis)	Reptilia	KCNJ4⁶	--	79(a)	1 ↔ 1	GL343460.1(566097-567458)
zebrafish (Danio rerio)	Actinopterygii	LOC100331864¹	ATP-sensitive inward rectifier potassium channel 12-like	67.14(n) 63.23(a)		100331864 XM_002667394.2 XP_002667440.2
fruit fly (Drosophila melanogaster)	Insecta	Ir³	inward rectifier potassium channel	51(a) (best of 3)		94E4 --
worm (Caenorhabditis elegans)	Secernentea	irk-1³	inward rectifier potassium channel (IRK)	48(a) (best of 2)		X(6802509-6806908) --

ENSEMBL Gene Tree for KCNJ4 (if available)
TreeFam Gene Tree for KCNJ4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNJ4 gene

KCNJ9² KCNJ16² KCNJ8² KCNJ1² KCNJ15² KCNJ12² KCNJ5² KCNJ6²

KCNJ2² KCNJ10² KCNJ14² KCNJ3² KCNJ11²

16 SIMAP similar genes for KCNJ4 using alignment to 2 protein entries: IRK4_HUMAN (see all proteins):

KCNJ18 kcnj12x KCNJ12 KCNJ5 KCNJ2 KCNJ14

KCNJ6 KCNJ3 KCNJ9 KCNJ16 KCNJ1 KCNJ11

KCNJ8 KCNJ15 KCNJ10 KCNJ13

KCNJ4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148606264^1,2		--	38821915(+)	`GGAGAA/GTCGCT`	2	--	int¹		0	--	--	--	--
rs187074817^1,2		--	38821998(+)	`AACTCC/TGTCTC`	2	--	int¹		0	--	--	--	--
rs57307919^1,2	C	--	38822023(+)	`ATAAT-/AAAAAA TAAAA`	2	--	int¹		0	--	--	--	--
rs71938620^1,2	C	--	38822028(+)	`AAAAA-/ATAAAAA`	2	--	int¹		0	--	--	--	--
rs139162020^1,2		--	38822040(+)	`AAAAA-/TATATATA`	2	--	int¹		0	--	--	--	--
rs2002581^1,2	C,F,H	--	38822064(-)	`TGTAAC/TCATAT`	2	--	int¹		7		NS EA NA	540
rs117394897^1,2	F	--	38822203(+)	`GCTGGC/TGTTGA`	2	--	int¹		1		EA	120
rs196057^1,2	C,F,O,A,H	--	38822300(-)	`GGACAA/GGGAGA`	2	--	int¹		29		EA NA MN NS WA CSA	2982
rs59210869^1,2	C,F	--	38822332(+)	`GTGAAT/CTTGGT`	2	--	ut3¹		1		WA	118
rs61369346^1,2	C	--	38822417(+)	`ACGCA-/CCCCCC`	2	--	ut3¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for KCNJ4 (38822332 - 38851205 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KCNJ4
2 CNVs: 79579 9847
1 Indel: 59076

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KCNJ4 for disorders           About GeneDecksing

OMIM gene information: 600504    OMIM disorders: --

5 diseases for KCNJ4:    About MalaCards

meniere's disease menieres disease neuronitis hyperglycemia

noma

1 Novoseek disease relationship for KCNJ4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperglycemia	12.2	1	17563065 (1)

Human Genome Epidemiology (HuGE) Navigator: KCNJ4 (1 document)

Export disorders for KCNJ4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNJ4 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with KCNJ4)

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world of online information

Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. (PubMed id 8016146)^{1, 2, 3, 9} Perier F.... Vandenberg C.A. (1994)
Molecular mechanism of inward rectifier potassium cha nnel 2.3 regulation by tax-interacting protein-1. (PubMed id 19635485)^{1, 2} Yan X....Long J. (2009)
International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{1, 3} Kubo Y....Vandenberg C.A. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes. (PubMed id 8034048)^{1, 2} Tang W. and Yang X.-C. (1994)
Cloning and expression of a novel human brain inward rectifier potassium channel. (PubMed id 8051145)^{1, 2} Makhina E.N.... Nichols C.G. (1994)
Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. (PubMed id 8943291)^{1, 9} Cohen N.A....Nichols C.G. (1996)
Direct activation of an inwardly rectifying potassium channel by arachidonic acid. (PubMed id 11306688)^{1, 9} Liu Y....Curran M.E. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3761	HGNC: 6265	AceView: KCNJ4	Ensembl:ENSG00000168135	euGenes: HUgn3761
ECgene: KCNJ4	Kegg: 3761	H-InvDB: KCNJ4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KCNJ4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNJ4 gene
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Patent Information for KCNJ4 gene:
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