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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNJ3 Gene

protein-coding GIFtS: 65
GCID: GC02P155555

potassium inwardly-rectifying channel, subfamily J, member...

Explore 18 diseases affiliated with
KCNJ3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3¹ ²		Kir3.1¹
GIRK1¹ ² ³ ⁵		KIR3.1²
KGA¹ ²		G Protein-Activated Inward Rectifier Potassium Channel 1²
Inward Rectifier K(+) Channel Kir3.1² ³		Inward Rectifier K+ Channel KIR3.1²
Potassium Channel, Inwardly Rectifying Subfamily J Member 3² ³		Potassium Inwardly-Rectifying Channel Subfamily J Member 3 Splice Variant 1e²
GIRK-1² ³

External Ids:	HGNC: 6264¹	Entrez Gene: 3760²	Ensembl: ENSG00000162989⁷	OMIM: 601534⁵	UniProtKB: P48549³

Export aliases for KCNJ3 gene to outside databases

Previous GC identifers: GC02P153486 GC02P154084 GC02P155519 GC02P155757 GC02P155380 GC02P155263 GC02P147441

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ3:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic

responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium

channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a

cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other

G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to

neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by

hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels

may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease.

Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, May

2012)

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549

Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by

a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is

regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the

channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward

current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

summary for KCNJ3:

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong

inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the

ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the

pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two

membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each

subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within

subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNJ3 gene promoter:
HOXA9B HOXA9 GR NF-1 NF-1/L GATA-1 Meis-1b PPAR-alpha GR-alpha Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNJ3 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNJ3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.1

KCNJ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P155555: view genomic region (about GC identifiers)

Start:	155,554,811 bp from pter	End:	155,714,863 bp from pter
Size:	160,053 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549 (See protein sequence)

Recommended Name: G protein-activated inward rectifier potassium channel 1

Size: 501 amino acids; 56603 Da

Subunit: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The

resulting inward current is much larger (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B4DEW7 Q8TBI0

Alternative splicing: 2 isoforms: P48549-1 P48549-2

Explore the universe of human proteins at neXtProt for KCNJ3: NX_P48549

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48549

KCNJ3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001247437.1 NP_001247438.1 NP_001247439.1 NP_002230.1

ENSEMBL proteins:

ENSP00000295101 ENSP00000438410

Reactome Protein details: P48549
Human Recombinant Protein Products for KCNJ3:

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	TAS	8804710
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	--	--
GO:0016021	integral to membrane	--	--

KCNJ3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNJ3 for domains About GeneDecksing

4 InterPro domains/families:

IPR014756 Ig_E-set

IPR013518 K_chnl_inward-rec_Kir_cyto

IPR003274 K_chnl_inward-rec_Kir3.1

IPR016449 K_chnl_inward-rec_Kir

Graphical View of Domain Structure for InterPro Entry P48549

ProtoNet protein and cluster: P48549

2 Blocks protein families:

IPB001838 Inward rectifier K+ channel superfamily signature

IPB003274 Kir3.1 inward rectifier K+ channel signature

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549

Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IRK3_HUMAN, P48549

Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by

a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is

regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the

channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward

current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

Genatlas biochemistry entry for KCNJ3:

potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 3,expressed in heart,unlikely to be involved

in juvenile myoclonic epilepsy

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005242	contributes to inward rectifier potassium channel activity	IDA	12297500
GO:0005515	protein binding	IPI	12297500
GO:0015467	G-protein activated inward rectifier potassium channel activity	IEA	--

KCNJ3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for KCNJ3:

Synthetic lethal with Ras

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnj3):

cardiovascular system

KCNJ3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Kcnj3^tm1Kwn for KCNJ3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KCNJ3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Inwardly rectifying K+ channels

	Inwardly rectifying K+ channels	1.00			G protein gated Potassium channels	0.81
	Activation of G protein gated Potassium channels	0.81			Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.81

Activation of GABAB receptors

	Activation of GABAB receptors	1.00			GABA receptor activation	0.72
	GABA B receptor activation	1.00

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Potassium Channels

Potassium Channels

1.00

Potassium transporters: outward current

0.42

Antiarrhythmic Pathway, Pharmacodynamics

Antiarrhythmic Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for KCNJ3

	Potassium transporters- inward current
	Synaptic transmission- ion currents
	Potassium transporters- outward current

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNJ3

	G-Beta Gamma Signaling
	Dopamine-DARPP32 Feedback onto cAMP Pathway

2 BioSystems Pathways for KCNJ3

	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell

5/11 Reactome Pathways for KCNJ3 (see all 11)

	Transmission across Chemical Synapses
	G protein gated Potassium channels
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Inwardly rectifying K+ channels

1 PharmGKB Pathway for KCNJ3

Antiarrhythmic Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for KCNJ3):

	Glutamatergic synapse
	Cholinergic synapse

KCNJ3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNJ3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for KCNJ3 (P48549³ ENSP00000295101⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
KCNJ5	P48544³, ENSP00000339960⁴	I2D: score=2 STRING: ENSP00000339960
ADRB2	P07550³, ENSP00000305372⁴	I2D: score=1 STRING: ENSP00000305372
DRD4	P21917³, ENSP00000176183⁴	I2D: score=1 STRING: ENSP00000176183
KCNJ6	P48051³, ENSP00000383330⁴	I2D: score=1 STRING: ENSP00000383330

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	8804710
GO:0007268	synaptic transmission	TAS	--
GO:0051602	response to electrical stimulus	IEA	--

KCNJ3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNJ3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNJ3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Tertiapin-Q	Selective blocker of inward-rectifier K+ channels	[252198-49-5]

1 HMDB Compound for KCNJ3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for KCNJ3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Halothane	2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)	151-67-7	target	inhibitor	11465552 15175324 11455015

10 Novoseek chemical compound relationships for KCNJ3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carbetapentane	80.2	1	8872359 (1)
(+)-3-(3-hydroxyphenyl)-n-(1-propyl)piperidine	79.2	2	8872359 (1)
potassium	65.1	24	11212253 (2), 8088798 (2), 8683463 (2), 8051145 (1) (see all 15)
naloxone	36.5	1	9504382 (1)
clozapine	33.2	9	9504382 (5), 10780978 (1)
acetylcholine	31.1	1	9886054 (1)
gtp	23.8	1	8022483 (1)
dopamine	22	3	8609893 (1), 8581266 (1), 14556235 (1)
haloperidol	15.9	3	10780978 (1), 8872359 (1)
glutamine	4.86	2	8683463 (1), 12361957 (1)

Search CenterWatch for drugs/clinical trials and news about KCNJ3 / IRK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNJ3 gene (4 alternative transcripts):

NM_001260508.1 NM_001260509.1 NM_001260510.1 NM_002239.3

Unigene Cluster for KCNJ3:

Potassium inwardly-rectifying channel, subfamily J, member 3

Hs.591606 [show with all ESTs]

Unigene Representative Sequence: NM_002239

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295101(uc021vrh.1 uc002tyv.1 uc010zce.1) ENST00000493505

ENST00000544049

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Additional cDNA sequence:

AK026384.1 AK293824.1 AK293924.1 BC022495.1 GU068048.1 GU074515.1 GU074516.1 U50964.1

2 DOTS entries:

DT.40253730 DT.92419356

24 AceView cDNA sequences:

AI631968 BG702790 BX488523 NM_002239 BE327876 H91668 BG563492 U50964

BX488558 AW949825 BI913181 BX489066 BC022495 BQ303941 T35678 Z25911

CK023806 BQ303942 U39196 H91765 BQ342882 CD102361 Z25901 BG196127

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNJ3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACTTTAT

About this image

KCNJ3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

nGnG Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNJ3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ3

SOURCE GeneReport for Unigene cluster: Hs.591606

SABiosciences Expression via Pathway-Focused PCR Array including KCNJ3:

Neuronal Ion Channels in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNJ3 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNJ3¹	potassium inwardly-rectifying channel, subfamily J, more	82.45(n) 92.68(a)		396369 NM_205404.1 NP_990735.1
lizard (Anolis carolinensis)	Reptilia	KCNJ3⁶ KCNJ3⁶	--	95(a) 93(a)	1 ↔ 1 possible ortholog	GL343296.1(134793-147048) GL343254.1(1992662-1993249)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12058²	Transcribed sequence with moderate similarity to protein more	82.81(n)		BX703864.1
zebrafish (Danio rerio)	Actinopterygii	LOC100330491¹	G protein-activated inward rectifier potassium channel more	74.86(n) 85.66(a)		100330491 XM_002663310.2 XP_002663356.2
fruit fly (Drosophila melanogaster)	Insecta	Ir³	inward rectifier potassium channel	47(a) (best of 2)		94E4 --
worm (Caenorhabditis elegans)	Secernentea	irk-1³	inward rectifier potassium channel (IRK)	46(a) (best of 2)		X(6802509-6806908) --

ENSEMBL Gene Tree for KCNJ3 (if available)
TreeFam Gene Tree for KCNJ3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KCNJ3 gene

KCNJ4² KCNJ9² KCNJ16² KCNJ8² KCNJ1² KCNJ15² KCNJ12² KCNJ5²

KCNJ6² KCNJ2² KCNJ10² KCNJ14² KCNJ11²

16 SIMAP similar genes for KCNJ3 using alignment to 4 protein entries: IRK3_HUMAN (see all proteins):

KCNJ9 KCNJ5 KCNJ6 KCNJ1 KCNJ2 KCNJ11

KCNJ8 KCNJ15 KCNJ10 KCNJ12 KCNJ18 kcnj12x

KCNJ4 KCNJ14 KCNJ16 KCNJ13

KCNJ3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145455049^1,2	C	--	155553196(+)	`GGCTG-/ACAACCT`	4	--	us2k¹		0	--	--	--	--
rs3106660^1,2	C,F,A,H	--	155553275(-)	`TTACTC/TTATGC`	4	--	us2k¹		8		NS EA NA	664
rs146212836^1,2		--	155553462(+)	`TACTCA/GTGGGC`	4	--	us2k¹		0	--	--	--	--
rs139126777^1,2		--	155553470(+)	`GGCACG/TCTATT`	4	--	us2k¹		0	--	--	--	--
rs191001152^1,2		--	155553690(+)	`CTGAAA/TATGCC`	4	--	us2k¹		0	--	--	--	--
rs145531814^1,2		--	155553695(+)	`TATGC-/CTAT CTGAG`	4	--	us2k¹		0	--	--	--	--
rs150923283^1,2	C	--	155553782(+)	`GACATA/GTTGTA`	4	--	us2k¹		0	--	--	--	--
rs141106092^1,2		--	155553806(+)	`AGAGAA/GCAGCA`	4	--	us2k¹		0	--	--	--	--
rs149840839^1,2		--	155553832(+)	`GGGCTG/TTCTGA`	4	--	us2k¹		0	--	--	--	--
rs147930651^1,2		--	155553893(+)	`TAGAGC/TCGCTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNJ3 (155554811 - 155714863 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNJ3: --
Human Gene Mutation Database (HGMD): KCNJ3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNJ3 for disorders           About GeneDecksing

OMIM gene information: 601534    OMIM disorders: --

18 diseases for KCNJ3:    About MalaCards

maturity-onset diabetes of the young juvenile myoclonic epilepsy parkinson's disease down syndrome

anorexia nervosa insulinoma ataxia epilepsy syndrome

breast cancer sinusitis pertussis seizures

breast carcinoma lung cancer cholesterol carcinoma

pancreatitis neuronitis

6 Novoseek disease relationships for KCNJ3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma	32.3	1	7540174 (1)
adenocarcinoma	0.726	5	19465885 (3), 16109170 (1)
breast cancer	0	10	20512921 (3), 16945134 (2), 15603589 (1), 16109170 (1)
metastasis	0	5	11212253 (3), 15541182 (1)
tumors	0	5	15541182 (2), 11212253 (1)
cancer	0	3	15541182 (1), 16109170 (1)

Genetic Association Database (GAD): KCNJ3
Human Genome Epidemiology (HuGE) Navigator: KCNJ3 (4 documents)

Export disorders for KCNJ3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNJ3 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with KCNJ3)

Utopia: connect your pdf to the dynamic
world of online information

Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism. (PubMed id 8088798)^{1, 3, 9} Stoffel M....Bell G.I. (1994)
Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. (PubMed id 8804710)^{1, 2, 9} Schoots O.... van Tol H.H.M. (1996)
International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{1, 3} Kubo Y....Vandenberg C.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes. (PubMed id 12458027)^{1, 4} Chioza B....Makoff A.J. (2002)
A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins. (PubMed id 8868049)^{1, 2} Chan K.W....Logothetis D.E. (1996)
Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. (PubMed id 9108307)^{1, 9} Huang C.L....Jan L.Y. (1997)
Cloning and characterisation of GIRK1 variants result ing from alternative RNA editing of the KCNJ3 gene transcript in a human breast cancer cell line. (PubMed id 20512921)^{1, 9} Wagner V....Schreibmayer W. (2010)
Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. (PubMed id 16109170)^{1, 9} Plummer H.K....Schuller H.M. (2005)
Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1). (PubMed id 9119365)^{1, 9} Schoots O....Van Tol H.H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3760	HGNC: 6264	AceView: KCNJ3	Ensembl:ENSG00000162989	euGenes: HUgn3760
ECgene: KCNJ3	Kegg: 3760	H-InvDB: KCNJ3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNJ3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNJ3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNJ3 gene:
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GeneCards and IP:
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