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KCNJ3 Gene

protein-coding   GIFtS: 65
GCID: GC02P155555

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See KCNJ3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 31 2     KGA2
GIRK12 3 5     KIR3.12
Inward Rectifier K(+) Channel Kir3.12 3     G Protein-Activated Inward Rectifier Potassium Channel 12
Potassium Channel, Inwardly Rectifying Subfamily J Member 32 3     Inward Rectifier K+ Channel KIR3.12
GIRK-12 3     Potassium Inwardly-Rectifying Channel Subfamily J Member 3 Splice Variant
1e2

External Ids:    HGNC: 62641   Entrez Gene: 37602   Ensembl: ENSG000001629897   OMIM: 6015345   UniProtKB: P485493   

Export aliases for KCNJ3 gene to outside databases

Previous GC identifers: GC02P153486 GC02P154084 GC02P155519 GC02P155757 GC02P155380 GC02P155263 GC02P147441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNJ3 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out
of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with
three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also
couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential
firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium
(GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and
Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
(provided by RefSeq, May 2012)

GeneCards Summary for KCNJ3 Gene:
KCNJ3 (potassium inwardly-rectifying channel, subfamily J, member 3) is a protein-coding gene. Diseases associated with KCNJ3 include pancreas adenocarcinoma. GO annotations related to this gene include G-protein activated inward rectifier potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549
Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are
characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage
dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the
voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to
the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the
heartbeat

summary for KCNJ3 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNJ3 gene promoter:
         HOXA9B   HOXA9   GR   NF-1   NF-1/L   GATA-1   Meis-1b   PPAR-alpha   GR-alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ3 promoter sequence
   Search Chromatin IP Primers for KCNJ3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNJ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q24.1

KCNJ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P155555:  view genomic region     (about GC identifiers)

Start:
155,554,811 bp from pter      End:
155,714,863 bp from pter
Size:
160,053 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549 (See protein sequence)
Recommended Name: G protein-activated inward rectifier potassium channel 1  
Size: 501 amino acids; 56603 Da
Subunit: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The
resulting inward current is much larger (By similarity)
Secondary accessions: B4DEW7 Q8TBI0
Alternative splicing: 2 isoforms:  P48549-1   P48549-2   

Explore the universe of human proteins at neXtProt for KCNJ3: NX_P48549

Explore proteomics data for KCNJ3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNJ3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001247437.1  NP_001247438.1  NP_001247439.1  NP_002230.1  

    ENSEMBL proteins: 
     ENSP00000295101   ENSP00000438410  
    Reactome Protein details: P48549

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kir3.1
    Inwardly rectifying potassium channels

    4 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR013518 K_chnl_inward-rec_Kir_cyto
     IPR003274 K_chnl_inward-rec_Kir3.1
     IPR016449 K_chnl_inward-rec_Kir

    Graphical View of Domain Structure for InterPro Entry P48549

    ProtoNet protein and cluster: P48549

    2 Blocks protein domains:
    IPB001838 Inward rectifier K+ channel superfamily signature
    IPB003274 Kir3.1 inward rectifier K+ channel signature


    UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549
    Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily


    Find genes that share domains with KCNJ3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRK3_HUMAN, P48549
    Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are
    characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage
    dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the
    voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to
    the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the
    heartbeat

         Genatlas biochemistry entry for KCNJ3:
    potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 3,expressed in heart,unlikely to be
    involved in juvenile myoclonic epilepsy

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242contributes to inward rectifier potassium channel activity IDA12297500
    GO:0005515protein binding IPI12297500
    GO:0015467G-protein activated inward rectifier potassium channel activity IEA--
         
    Find genes that share ontologies with KCNJ3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNJ3:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnj3):
     cardiovascular system 

    Find genes that share phenotypes with KCNJ3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnj3tm1Kwn for KCNJ3

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    SwitchGear 3'UTR luciferase reporter plasmidKCNJ3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRK3_HUMAN, P48549: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS8804710
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with KCNJ3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNJ3 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    2Circadian entrainment
    Morphine addiction0.53
    Dopaminergic synapse0.37
    Retrograde endocannabinoid signaling0.51
    Cholinergic synapse0.37
    Circadian entrainment0.40
    Serotonergic synapse0.33
    Glutamatergic synapse0.39
    3Inwardly rectifying K+ channels
    Inwardly rectifying K+ channels0.82
    G protein gated Potassium channels0.82
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.82
    Activation of G protein gated Potassium channels0.82
    4GABA receptor activation
    GABA B receptor activation0.73
    GABA receptor activation0.73
    Activation of GABAB receptors0.73
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72


    Find genes that share SuperPaths with KCNJ3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KCNJ3
        G-Beta Gamma Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 BioSystems Pathways for KCNJ3
        G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell

    2 Reactome Pathways for KCNJ3
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
    Activation of G protein gated Potassium channels

    1 PharmGKB Pathway for KCNJ3
        Antiarrhythmic Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for KCNJ3) (see all 9):
        Circadian entrainment
    Retrograde endocannabinoid signaling
    Glutamatergic synapse
    Cholinergic synapse
    Serotonergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ3: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNJ3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNJ3 (P485493 ENSP000002951014) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNB1P628733, ENSP000003678724I2D: score=2 STRING: ENSP00000367872
    KCNJ5P485443, ENSP000003399604I2D: score=2 STRING: ENSP00000339960
    ADRB2P075503, ENSP000003053724I2D: score=1 STRING: ENSP00000305372
    DRD4P219173, ENSP000001761834I2D: score=1 STRING: ENSP00000176183
    KCNJ9Q928063, ENSP000003570674I2D: score=1 STRING: ENSP00000357067
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8804710
    GO:0007268synaptic transmission TAS--
    GO:0051602response to electrical stimulus IEA--
    GO:0071805potassium ion transmembrane transport TAS8804710

    Find genes that share ontologies with KCNJ3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for KCNJ3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
    DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
    GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
    P1075Potent Kir6 (KATP) channel opener[60559-98-0]
    Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

    1 HMDB Compound for KCNJ3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for KCNJ3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetinhibitor11465552 15175324 11455015

    3 IUPHAR Ligands for KCNJ3 (Kir3.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    Na+
    ActivatorAgonist1.4 - 1.610085101
    PIP2
    ActivatorNone1.4 - 1.6--
    Ba2+
    Pore BlockerAntagonist1.4 - 1.68804710

    10 Novoseek inferred chemical compound relationships for KCNJ3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbetapentane 80.2 1 8872359 (1)
    (+)-3-(3-hydroxyphenyl)-n-(1-propyl)piperidine 79.2 2 8872359 (1)
    potassium 65.1 24 11212253 (2), 8088798 (2), 8683463 (2), 8051145 (1) (see all 15)
    naloxone 36.5 1 9504382 (1)
    clozapine 33.2 9 9504382 (5), 10780978 (1)
    acetylcholine 31.1 1 9886054 (1)
    gtp 23.8 1 8022483 (1)
    dopamine 22 3 8609893 (1), 8581266 (1), 14556235 (1)
    haloperidol 15.9 3 10780978 (1), 8872359 (1)
    glutamine 4.86 2 8683463 (1), 12361957 (1)



    Find genes that share compounds with KCNJ3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNJ3 gene (4 alternative transcripts): 
    NM_001260508.1  NM_001260509.1  NM_001260510.1  NM_002239.3  

    Unigene Cluster for KCNJ3:

    Potassium inwardly-rectifying channel, subfamily J, member 3
    Hs.591606  [show with all ESTs]
    Unigene Representative Sequence: NM_002239
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295101(uc021vrh.1 uc002tyv.1 uc010zce.1) ENST00000493505
    ENST00000544049
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    Additional mRNA sequence: 

    AK026384.1 AK293824.1 AK293924.1 BC022495.1 GU068048.1 GU074515.1 GU074516.1 U50964.1 

    2 DOTS entries:

    DT.40253730  DT.92419356 

    24 AceView cDNA sequences:

    NM_002239 BE327876 H91668 AI631968 BG563492 BX488523 BG702790 BX489066 
    T35678 BI913181 AW949825 BX488558 U50964 BC022495 BQ303941 Z25911 
    BQ303942 U39196 CK023806 BQ342882 H91765 CD102361 BG196127 Z25901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNJ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTTTAT
    KCNJ3 Expression
    About this image


    KCNJ3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 3 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Heart (Cardiovascular System)
     
     Testis (Reproductive System)
    KCNJ3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNJ3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591606
        Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ3: 
              Neuronal Ion Channels in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNJ3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnj31 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 93.28(n)1
    99(a)1
      2 (31.66 cM)5
    165191  NM_008426.11  NP_032452.11 
     554359705 
    chicken
    (Gallus gallus)
    Aves KCNJ31 potassium inwardly-rectifying channel, subfamily J, more 82.52(n)
    92.68(a)
      396369  NM_205404.1  NP_990735.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNJ36
    potassium inwardly-rectifying channel, subfamily J...
    95(a)
    1 ↔ 1
    GL343296.1(134663-147756)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120582 Transcribed sequence with moderate similarity to protein more 82.81(n)    BX703864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-83c10.11 si:ch73-83c10.1 74.86(n)
    85.66(a)
      100330491  XM_002663310.3  XP_002663356.2 


    ENSEMBL Gene Tree for KCNJ3 (if available)
    TreeFam Gene Tree for KCNJ3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNJ3 gene
    KCNJ42  KCNJ92  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ152  KCNJ52  
    KCNJ62  KCNJ22  KCNJ102  KCNJ142  KCNJ112  
    16 SIMAP similar genes for KCNJ3 using alignment to 4 protein entries:     IRK3_HUMAN (see all proteins):
    KCNJ9    KCNJ5    KCNJ6    KCNJ1    KCNJ2    KCNJ11
    KCNJ8    KCNJ15    KCNJ10    KCNJ12    KCNJ18    kcnj12x
    KCNJ4    KCNJ14    KCNJ16    KCNJ13

    Find genes that share paralogs with KCNJ3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNJ3 (see all 3099)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346088911,2
    C--147541545(+) CACAC-/GCACAGA 2 -- int11Minor allele frequency- GC:0.00NA 2
    rs1454550491,2
    C--155553196(+) GGCTG-/ACAACCT 4 -- us2k10--------
    rs31066601,2
    C,F,A,H--155553275(-) TTACTC/TTATGC 4 -- us2k18Minor allele frequency- T:0.03NS EA NA 664
    rs1462128361,2
    --155553462(+) TACTCA/GTGGGC 4 -- us2k10--------
    rs1391267771,2
    --155553470(+) GGCACG/TCTATT 4 -- us2k10--------
    rs1910011521,2
    --155553690(+) CTGAAA/TATGCC 4 -- us2k10--------
    rs1455318141,2
    C--155553695(+) TATGC-/CTAT  
            
    CTGAG
    4 -- us2k10--------
    rs1509232831,2
    C--155553782(+) GACATA/GTTGTA 4 -- us2k10--------
    rs1411060921,2
    --155553806(+) AGAGAA/GCAGCA 4 -- us2k10--------
    rs1498408391,2
    --155553832(+) GGGCTG/TTCTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNJ3 (155554811 - 155714863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KCNJ3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2984CNV Insertion18451855
    nsv875306CNV Loss21882294
    nsv875308CNV Loss21882294
    nsv875307CNV Loss21882294
    nsv834429CNV Gain17160897
    nsv7331OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): KCNJ3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNJ3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601534    OMIM disorders: --

    1 disease for KCNJ3:    
    About MalaCards
    pancreas adenocarcinoma


    Find genes that share disorders with KCNJ3           About GenesLikeMe

    6 Novoseek inferred disease relationships for KCNJ3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulinoma 32.3 1 7540174 (1)
    adenocarcinoma 0.726 5 19465885 (3), 16109170 (1)
    breast cancer 0 10 20512921 (3), 16945134 (2), 15603589 (1), 16109170 (1)
    metastasis 0 5 11212253 (3), 15541182 (1)
    tumors 0 5 15541182 (2), 11212253 (1)
    cancer 0 3 15541182 (1), 16109170 (1)

    Genetic Association Database (GAD): KCNJ3
    Human Genome Epidemiology (HuGE) Navigator: KCNJ3 (4 documents)

    Export disorders for KCNJ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNJ3 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with KCNJ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism. (PubMed id 8088798)1, 3, 9 Stoffel M....Bell G.I. (Genomics 1994)
    2. Genetic variation in the inwardly rectifying K channel subunits KCNJ3 (GIRK1) and KCNJ5 (GIRK4) in patients with sinus node dysfunction. (PubMed id 20110696)1, 4, 9 Holmegard H.N....Svendsen J.H. (Cardiology 2010)
    3. Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. (PubMed id 8804710)1, 2, 9 Schoots O.... van Tol H.H.M. (Brain Res. Mol. Brain Res. 1996)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (Pharmacol. Rev. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes. (PubMed id 12458027)1, 4 Chioza B....Makoff A.J. (Epilepsy Res. 2002)
    8. Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. (PubMed id 10889209)1, 2 Pabon A.... Thornhill W.B. (J. Biol. Chem. 2000)
    9. A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins. (PubMed id 8868049)1, 2 Chan K.W....Logothetis D.E. (J. Gen. Physiol. 1996)
    10. Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. (PubMed id 9108307)1, 9 Huang C.L....Jan L.Y. (FEBS Lett. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3760 HGNC: 6264 AceView: KCNJ3 Ensembl:ENSG00000162989 euGenes: HUgn3760
    ECgene: KCNJ3 Kegg: 3760 H-InvDB: KCNJ3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNJ3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNJ3 gene:
    Search GeneIP for patents involving KCNJ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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