Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNJ3 Gene

protein-coding GIFtS: 65
GCID: GC02P155555

potassium inwardly-rectifying channel, subfamily J, member...

Explore 18 diseases affiliated with
KCNJ3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3¹ ²		Kir3.1¹
GIRK1¹ ² ³ ⁵		KIR3.1²
KGA¹ ²		G Protein-Activated Inward Rectifier Potassium Channel 1²
Inward Rectifier K(+) Channel Kir3.1² ³		Inward Rectifier K+ Channel KIR3.1²
Potassium Channel, Inwardly Rectifying Subfamily J Member 3² ³		Potassium Inwardly-Rectifying Channel Subfamily J Member 3 Splice Variant 1e²
GIRK-1² ³

External Ids:	HGNC: 6264¹	Entrez Gene: 3760²	Ensembl: ENSG00000162989⁷	OMIM: 601534⁵	UniProtKB: P48549³

Export aliases for KCNJ3 gene to outside databases

Previous GC identifers: GC02P153486 GC02P154084 GC02P155519 GC02P155757 GC02P155380 GC02P155263 GC02P147441

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ3:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic

responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium

channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a

cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other

G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to

neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by

hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels

may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease.

Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, May

2012)

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549

Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by

a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is

regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the

channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward

current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

summary for KCNJ3:

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong

inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the

ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the

pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two

membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each

subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within

subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNJ3 gene promoter:
HOXA9B HOXA9 GR NF-1 NF-1/L GATA-1 Meis-1b PPAR-alpha GR-alpha Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNJ3 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNJ3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.1

KCNJ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P155555: view genomic region (about GC identifiers)

Start:	155,554,811 bp from pter	End:	155,714,863 bp from pter
Size:	160,053 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549 (See protein sequence)

Recommended Name: G protein-activated inward rectifier potassium channel 1

Size: 501 amino acids; 56603 Da

Subunit: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The

resulting inward current is much larger (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: B4DEW7 Q8TBI0

Alternative splicing: 2 isoforms: P48549-1 P48549-2

Explore the universe of human proteins at neXtProt for KCNJ3: NX_P48549

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48549

KCNJ3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001247437.1 NP_001247438.1 NP_001247439.1 NP_002230.1

ENSEMBL proteins:

ENSP00000295101 ENSP00000438410

Reactome Protein details: P48549
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KCNJ3 OriGene Custom Protein Services for KCNJ3
	GenScript Custom Purified and Recombinant Proteins Services for KCNJ3
	Novus Biologicals KCNJ3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KCNJ3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	TAS	8804710
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	--	--
GO:0016021	integral to membrane	--	--

KCNJ3 for ontologies About GeneDecksing

KCNJ3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNJ3
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 10): KCNJ3 OriGene Custom Antibody Services for KCNJ3
	GenScript Custom Superior Antibodies Services for KCNJ3
	Novus Biologicals KCNJ3 Antibodies
	Abcam antibodies for KCNJ3
	Uscn Antibodies for KCNJ3
	ThermoFisher Antibodies for KCNJ3

Assay Products for KCNJ3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNJ3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KCNJ3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNJ3 for domains About GeneDecksing

4 InterPro domains/families:

IPR014756 Ig_E-set

IPR013518 K_chnl_inward-rec_Kir_cyto

IPR003274 K_chnl_inward-rec_Kir3.1

IPR016449 K_chnl_inward-rec_Kir

Graphical View of Domain Structure for InterPro Entry P48549

ProtoNet protein and cluster: P48549

2 Blocks protein families:

IPB001838 Inward rectifier K+ channel superfamily signature

IPB003274 Kir3.1 inward rectifier K+ channel signature

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549

Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IRK3_HUMAN, P48549

Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by

a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is

regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the

channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward

current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

Genatlas biochemistry entry for KCNJ3:

potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 3,expressed in heart,unlikely to be involved

in juvenile myoclonic epilepsy

miRNA Products:		OriGene 3'-UTR Clone: KCNJ3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNJ3
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNJ3 (see all 40):
		hsa-miR-142-5p hsa-miR-548j hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-374c hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: KCNJ3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNJ3 (see all 7) OriGene shRNA RFP: KCNJ3 OriGene siRNA: KCNJ3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNJ3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCNJ3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNJ3 (NM_002239)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNJ3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNJ3
		Search LifeMap BioReagents cell lines for KCNJ3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005242	contributes to inward rectifier potassium channel activity	IDA	12297500
GO:0005515	protein binding	IPI	12297500
GO:0015467	G-protein activated inward rectifier potassium channel activity	IEA	--

KCNJ3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KCNJ3:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Kcnj3^tm1Kwn for KCNJ3
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnj3):

cardiovascular system

KCNJ3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Inwardly rectifying K+ channels

	Inwardly rectifying K+ channels	1.00			G protein gated Potassium channels	0.81
	Activation of G protein gated Potassium channels	0.81			Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.81

Activation of GABAB receptors

	Activation of GABAB receptors	1.00			GABA receptor activation	0.72
	GABA B receptor activation	1.00

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Potassium Channels

Potassium Channels

1.00

Potassium transporters: outward current

0.42

Antiarrhythmic Pathway, Pharmacodynamics

Antiarrhythmic Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for KCNJ3

	Potassium transporters- inward current
	Synaptic transmission- ion currents
	Potassium transporters- outward current

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for KCNJ3

	G-Beta Gamma Signaling
	Dopamine-DARPP32 Feedback onto cAMP Pathway

2 BioSystems Pathways for KCNJ3

	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell

5/11 Reactome Pathways for KCNJ3 (see all 11)

	Transmission across Chemical Synapses
	G protein gated Potassium channels
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Inwardly rectifying K+ channels

1 PharmGKB Pathway for KCNJ3

Antiarrhythmic Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for KCNJ3):

	Glutamatergic synapse
	Cholinergic synapse

KCNJ3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNJ3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for KCNJ3 (P48549³ ENSP00000295101⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB1	P62873³, ENSP00000367872⁴	I2D: score=2 STRING: ENSP00000367872
KCNJ5	P48544³, ENSP00000339960⁴	I2D: score=2 STRING: ENSP00000339960
ADRB2	P07550³, ENSP00000305372⁴	I2D: score=1 STRING: ENSP00000305372
DRD4	P21917³, ENSP00000176183⁴	I2D: score=1 STRING: ENSP00000176183
KCNJ6	P48051³, ENSP00000383330⁴	I2D: score=1 STRING: ENSP00000383330

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	TAS	8804710
GO:0007268	synaptic transmission	TAS	--
GO:0051602	response to electrical stimulus	IEA	--

KCNJ3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KCNJ3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNJ3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Tertiapin-Q	Selective blocker of inward-rectifier K+ channels	[252198-49-5]

1 HMDB Compound for KCNJ3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 DrugBank Compound for KCNJ3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Halothane	2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)	151-67-7	target	inhibitor	11465552 15175324 11455015

10 Novoseek chemical compound relationships for KCNJ3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carbetapentane	80.2	1	8872359 (1)
(+)-3-(3-hydroxyphenyl)-n-(1-propyl)piperidine	79.2	2	8872359 (1)
potassium	65.1	24	11212253 (2), 8088798 (2), 8683463 (2), 8051145 (1) (see all 15)
naloxone	36.5	1	9504382 (1)
clozapine	33.2	9	9504382 (5), 10780978 (1)
acetylcholine	31.1	1	9886054 (1)
gtp	23.8	1	8022483 (1)
dopamine	22	3	8609893 (1), 8581266 (1), 14556235 (1)
haloperidol	15.9	3	10780978 (1), 8872359 (1)
glutamine	4.86	2	8683463 (1), 12361957 (1)

Search CenterWatch for drugs/clinical trials and news about KCNJ3 / IRK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNJ3 gene (4 alternative transcripts):

NM_001260508.1 NM_001260509.1 NM_001260510.1 NM_002239.3

Unigene Cluster for KCNJ3:

Potassium inwardly-rectifying channel, subfamily J, member 3

Hs.591606 [show with all ESTs]

Unigene Representative Sequence: NM_002239

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295101(uc021vrh.1 uc002tyv.1 uc010zce.1) ENST00000493505

ENST00000544049

miRNA Products:		OriGene 3'-UTR Clone: KCNJ3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNJ3
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNJ3 (see all 40):
		hsa-miR-142-5p hsa-miR-548j hsa-miR-300 hsa-miR-25 hsa-miR-30d hsa-miR-507 hsa-miR-374c hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: KCNJ3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNJ3 (see all 7) OriGene shRNA RFP: KCNJ3 OriGene siRNA: KCNJ3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNJ3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KCNJ3 (NM_002239)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNJ3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNJ3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNJ3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNJ3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ3

Additional cDNA sequence:

AK026384.1 AK293824.1 AK293924.1 BC022495.1 GU068048.1 GU074515.1 GU074516.1 U50964.1

2 DOTS entries:

DT.40253730 DT.92419356

24 AceView cDNA sequences:

AI631968 BG702790 BX488523 NM_002239 BE327876 H91668 BG563492 U50964

BX488558 AW949825 BI913181 BX489066 BC022495 BQ303941 T35678 Z25911

CK023806 BQ303942 U39196 H91765 BQ342882 CD102361 Z25901 BG196127

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNJ3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACTTTAT

About this image

KCNJ3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

nGnG Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNJ3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ3

SOURCE GeneReport for Unigene cluster: Hs.591606

SABiosciences Expression via Pathway-Focused PCR Array including KCNJ3:

Neuronal Ion Channels in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNJ3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNJ3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNJ3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNJ3 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNJ3¹	potassium inwardly-rectifying channel, subfamily J, more	82.45(n) 92.68(a)		396369 NM_205404.1 NP_990735.1
lizard (Anolis carolinensis)	Reptilia	KCNJ3⁶ KCNJ3⁶	--	95(a) 93(a)	1 ↔ 1 possible ortholog	GL343296.1(134793-147048) GL343254.1(1992662-1993249)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12058²	Transcribed sequence with moderate similarity to protein more	82.81(n)		BX703864.1
zebrafish (Danio rerio)	Actinopterygii	LOC100330491¹	G protein-activated inward rectifier potassium channel more	74.86(n) 85.66(a)		100330491 XM_002663310.2 XP_002663356.2
fruit fly (Drosophila melanogaster)	Insecta	Ir³	inward rectifier potassium channel	47(a) (best of 2)		94E4 --
worm (Caenorhabditis elegans)	Secernentea	irk-1³	inward rectifier potassium channel (IRK)	46(a) (best of 2)		X(6802509-6806908) --

ENSEMBL Gene Tree for KCNJ3 (if available)
TreeFam Gene Tree for KCNJ3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNJ3 gene

KCNJ4² KCNJ9² KCNJ16² KCNJ8² KCNJ1² KCNJ15² KCNJ12² KCNJ5²

KCNJ6² KCNJ2² KCNJ10² KCNJ14² KCNJ11²

16 SIMAP similar genes for KCNJ3 using alignment to 4 protein entries: IRK3_HUMAN (see all proteins):

KCNJ9 KCNJ5 KCNJ6 KCNJ1 KCNJ2 KCNJ11

KCNJ8 KCNJ15 KCNJ10 KCNJ12 KCNJ18 kcnj12x

KCNJ4 KCNJ14 KCNJ16 KCNJ13

KCNJ3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145455049^1,2	C,	--	155553196(+)	`GGCTG-/ACAACCT`	4	--	us2k¹		0	--	--	--	--
rs3106660^1,2	C,F,A,H,	--	155553275(-)	`TTACTC/TTATGC`	4	--	us2k¹		8		NS EA NA	664
rs146212836^1,2		--	155553462(+)	`TACTCA/GTGGGC`	4	--	us2k¹		0	--	--	--	--
rs139126777^1,2		--	155553470(+)	`GGCACG/TCTATT`	4	--	us2k¹		0	--	--	--	--
rs191001152^1,2		--	155553690(+)	`CTGAAA/TATGCC`	4	--	us2k¹		0	--	--	--	--
rs145531814^1,2		--	155553695(+)	`TATGC-/CTAT CTGAG`	4	--	us2k¹		0	--	--	--	--
rs150923283^1,2	C,	--	155553782(+)	`GACATA/GTTGTA`	4	--	us2k¹		0	--	--	--	--
rs141106092^1,2		--	155553806(+)	`AGAGAA/GCAGCA`	4	--	us2k¹		0	--	--	--	--
rs149840839^1,2		--	155553832(+)	`GGGCTG/TTCTGA`	4	--	us2k¹		0	--	--	--	--
rs147930651^1,2		--	155553893(+)	`TAGAGC/TCGCTT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNJ3 (155554811 - 155714863 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNJ3: --
Human Gene Mutation Database (HGMD): KCNJ3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ3

DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNJ3 for disorders           About GeneDecksing

OMIM gene information: 601534    OMIM disorders: --

18 diseases for KCNJ3:    About MalaCards

maturity-onset diabetes of the young juvenile myoclonic epilepsy parkinson's disease down syndrome

anorexia nervosa insulinoma ataxia epilepsy syndrome

breast cancer sinusitis pertussis seizures

breast carcinoma lung cancer cholesterol carcinoma

pancreatitis neuronitis

6 Novoseek disease relationships for KCNJ3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulinoma	32.3	1	7540174 (1)
adenocarcinoma	0.726	5	19465885 (3), 16109170 (1)
breast cancer	0	10	20512921 (3), 16945134 (2), 15603589 (1), 16109170 (1)
metastasis	0	5	11212253 (3), 15541182 (1)
tumors	0	5	15541182 (2), 11212253 (1)
cancer	0	3	15541182 (1), 16109170 (1)

Genetic Association Database (GAD): KCNJ3
Human Genome Epidemiology (HuGE) Navigator: KCNJ3 (4 documents)

Export disorders for KCNJ3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNJ3 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with KCNJ3)

Utopia: connect your pdf to the dynamic
world of online information

Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism. (PubMed id 8088798)^{1, 3, 9} Stoffel M....Bell G.I. (1994)
Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. (PubMed id 8804710)^{1, 2, 9} Schoots O.... van Tol H.H.M. (1996)
International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{1, 3} Kubo Y....Vandenberg C.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Suggestive evidence for association of two potassium channel genes with different idiopathic generalised epilepsy syndromes. (PubMed id 12458027)^{1, 4} Chioza B....Makoff A.J. (2002)
A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins. (PubMed id 8868049)^{1, 2} Chan K.W....Logothetis D.E. (1996)
Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. (PubMed id 9108307)^{1, 9} Huang C.L....Jan L.Y. (1997)
Cloning and characterisation of GIRK1 variants result ing from alternative RNA editing of the KCNJ3 gene transcript in a human breast cancer cell line. (PubMed id 20512921)^{1, 9} Wagner V....Schreibmayer W. (2010)
Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. (PubMed id 16109170)^{1, 9} Plummer H.K....Schuller H.M. (2005)
Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1). (PubMed id 9119365)^{1, 9} Schoots O....Van Tol H.H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3760	HGNC: 6264	AceView: KCNJ3	Ensembl:ENSG00000162989	euGenes: HUgn3760
ECgene: KCNJ3	Kegg: 3760	H-InvDB: KCNJ3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNJ3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNJ3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNJ3 gene:
Search GeneIP for patents involving KCNJ3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of KCNJ3
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for KCNJ3		OriGene shRNA RFP for KCNJ3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNJ3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNJ3
	OriGene Protein Over-expression Lysate for KCNJ3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KCNJ3		OriGene 3'-UTR Clone for KCNJ3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCNJ3		OriGene Custom Protein Services for KCNJ3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNJ3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNJ3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNJ3

	GenScript Custom Purified and Recombinant Proteins Services for KCNJ3		GenScript cDNA clones with any tag delivered in your preferred vector for KCNJ3
	GenScript Custom Assay Services for KCNJ3		GenScript Custom Superior Antibodies Services for KCNJ3
	GenScript Custom overexpressing Cell Line Services for KCNJ3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNJ3 promoter
	Search Chromatin IP Primers for KCNJ3
	RT² qPCR Primer Assay in human, mouse, rat KCNJ3
	GNC Network for KCNJ3
	SABiosciences PCR Arrays including human, mouse, rat KCNJ3

Tocris compounds for KCNJ3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCNJ3 antibodies
	KCNJ3 lysates

	Antibodies for KCNJ3
	See all of Abcam's Antibodies, Kits and Proteins for KCNJ3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

KCNJ3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for KCNJ3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ3

	SwitchGear 3'UTR luciferase reporter plasmids for KCNJ3
	SwitchGear Promoter luciferase reporter plasmids for KCNJ3

ThermoFisher Antibodies for KCNJ3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCNJ3 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KCNJ3 Gene

potassium inwardly-rectifying channel, subfamily J, member...

Aliases
for KCNJ3 gene

Summaries
for KCNJ3 gene

Genomic Views
for KCNJ3 gene

Proteins
for KCNJ3 gene

Protein Domains /
Families
for KCNJ3 gene

Function
for KCNJ3 gene

Pathways & Interactions
for KCNJ3 gene

Drugs & Compounds
for KCNJ3 gene

Transcripts
for KCNJ3 gene

Expression
for KCNJ3 gene

Orthologs
for KCNJ3 gene

Paralogs
for KCNJ3 gene

Genomic Variants
for KCNJ3 gene

Disorders / Diseases
for KCNJ3 gene

Publications
for KCNJ3 gene

External Searches for KCNJ3 gene

Genome Databases showing KCNJ3 gene

Other Databases showing KCNJ3 gene

Specialized Databases showing KCNJ3 gene

Intellectual Property
for KCNJ3 gene

Products
for KCNJ3 gene

View Random Gene

Advanced Search

Export list of displayed genes

KCNJ3 Gene

potassium inwardly-rectifying channel, subfamily J, member...

Aliasesfor KCNJ3 gene

Summariesfor KCNJ3 gene

Genomic Viewsfor KCNJ3 gene

Proteinsfor KCNJ3 gene

Protein Domains /Familiesfor KCNJ3 gene

Functionfor KCNJ3 gene

Pathways & Interactionsfor KCNJ3 gene

Drugs & Compoundsfor KCNJ3 gene

Transcriptsfor KCNJ3 gene

Expression for KCNJ3 gene

Orthologsfor KCNJ3 gene

Paralogsfor KCNJ3 gene

Genomic Variantsfor KCNJ3 gene

Disorders / Diseasesfor KCNJ3 gene

Publicationsfor KCNJ3 gene

External Searches for KCNJ3 gene

Genome Databases showing KCNJ3 gene

Other Databases showing KCNJ3 gene

Specialized Databases showing KCNJ3 gene

Intellectual Propertyfor KCNJ3 gene

Productsfor KCNJ3 gene

View Random Gene

Aliases
for KCNJ3 gene

Summaries
for KCNJ3 gene

Genomic Views
for KCNJ3 gene

Proteins
for KCNJ3 gene

Protein Domains /
Families
for KCNJ3 gene

Function
for KCNJ3 gene

Pathways & Interactions
for KCNJ3 gene

Drugs & Compounds
for KCNJ3 gene

Transcripts
for KCNJ3 gene

Expression
for KCNJ3 gene

Orthologs
for KCNJ3 gene

Paralogs
for KCNJ3 gene

Genomic Variants
for KCNJ3 gene

Disorders / Diseases
for KCNJ3 gene

Publications
for KCNJ3 gene

Intellectual Property
for KCNJ3 gene

Products
for KCNJ3 gene