Aliases for KCNJ18 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 18 2 3 5
- Inward Rectifier K(+) Channel Kir2.6 3 4
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 18 2
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 18 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 18 4
- Thyrotoxic Periodic Paralysis Susceptibility Ion Channel 3
External Ids for KCNJ18 Gene
Previous GeneCards Identifiers for KCNJ18 Gene
This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]
GeneCards Summary for KCNJ18 Gene
KCNJ18 (Potassium Voltage-Gated Channel Subfamily J Member 18) is a Protein Coding gene. Diseases associated with KCNJ18 include Thyrotoxic Periodic Paralysis 2 and Thyrotoxic Periodic Paralysis 1. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ12.
UniProtKB/Swiss-Prot for KCNJ18 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.