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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNJ16 Gene

protein-coding GIFtS: 61
GCID: GC17P068071

potassium inwardly-rectifying channel, subfamily J, member...

Explore 4 diseases affiliated with
KCNJ16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16¹ ²		KIR5.1² ⁵
BIR9¹ ²		Kir5.1¹
Inward Rectifier K(+) Channel Kir5.1² ³		Inward Rectifier K+ Channel KIR5.1²
Potassium Channel, Inwardly Rectifying Subfamily J Member 16² ³		Inward Rectifier Potassium Channel 16²

External Ids:	HGNC: 6262¹	Entrez Gene: 3773²	Ensembl: ENSG00000153822⁷	OMIM: 605722⁵	UniProtKB: Q9NPI9³

Export aliases for KCNJ16 gene to outside databases

Previous GC identifers: GC17P067826 GC17P071031 GC17P068535 GC17P068668 GC17P065583 GC17P063457

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ16:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic

responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium

channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a

cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the

regulation of fluid and pH balance. Alternatively spliced transcript variants encoding the same protein have been

found for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9

Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into

the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;

as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward

rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the

regulation of fluid and pH balance

summary for KCNJ16:

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong

inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the

ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the

pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two

membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each

subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within

subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNJ16 gene promoter:
AP-1 FOXO3 C/EBPalpha SRY POU2F1 POU2F1a FOXO3a ARP-1 STAT3 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNJ16 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNJ16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.3 Ensembl cytogenetic band: 17q24.3 HGNC cytogenetic band: 17q24.3

KCNJ16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ16 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P068071: view genomic region (about GC identifiers)

Start:	68,049,570 bp from pter	End:	68,131,749 bp from pter
Size:	82,180 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9 (See protein sequence)

Recommended Name: Inward rectifier potassium channel 16

Size: 418 amino acids; 47949 Da

Subunit: Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2

Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNJ16: NX_Q9NPI9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NPI9

KCNJ16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001257351.1 NP_061128.1 NP_733937.1

ENSEMBL proteins:

ENSP00000465646 ENSP00000465967 ENSP00000467568 ENSP00000465295 ENSP00000466132

ENSP00000465163 ENSP00000283936 ENSP00000376439 ENSP00000376438

Reactome Protein details: Q9NPI9
Human Recombinant Protein Products:

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	Uscn Proteins for KCNJ16

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	NAS	11060447

KCNJ16 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNJ16 for domains About GeneDecksing

4 InterPro domains/families:

IPR014756 Ig_E-set

IPR013518 K_chnl_inward-rec_Kir_cyto

IPR016449 K_chnl_inward-rec_Kir

IPR008061 K_chnl_inward-rec_Kir5

Graphical View of Domain Structure for InterPro Entry Q9NPI9

ProtoNet protein and cluster: Q9NPI9

2 Blocks protein families:

IPB001838 Inward rectifier K+ channel superfamily signature

IPB008061 Kir5 inward rectifier K+ channel signature

UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9

Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9

Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into

the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;

as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward

rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the

regulation of fluid and pH balance

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ16

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005242	inward rectifier potassium channel activity	NAS	11060447
GO:0005515	protein binding	--	--

KCNJ16 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for KCNJ16:

Decreased Wnt reporter activit

Increased G2M DNA content

Increased number of mitotic ce

Animal Models:
Mouse knock-outs for KCNJ16: Kcnj16^tm1Pess Kcnj16^tm1Lex
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnj16):

behavior/neurological	growth/size	homeostasis/metabolism	integument	nervous system
other	skeleton

KCNJ16 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Inwardly rectifying K+ channels

	Inwardly rectifying K+ channels	1.00			G protein gated Potassium channels	0.81
	Activation of G protein gated Potassium channels	0.81			Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.81

Activation of GABAB receptors

	Activation of GABAB receptors	1.00			GABA receptor activation	0.72
	GABA B receptor activation	1.00

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Potassium Channels

Potassium Channels

1.00

Potassium transport channels

Potassium transport channels

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KCNJ16

Potassium transporters- inward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ16

Dopamine-DARPP32 Feedback onto cAMP Pathway

5/12 Reactome Pathways for KCNJ16 (see all 12)

	Transmission across Chemical Synapses
	G protein gated Potassium channels
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Inwardly rectifying K+ channels

1 Kegg Pathway (Kegg details for KCNJ16):

Gastric acid secretion

KCNJ16 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KCNJ16

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for KCNJ16 (Q9NPI9³ ENSP00000283936⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNJ2	P63252³, ENSP00000243457⁴	I2D: score=1 STRING: ENSP00000243457
KCNJ10	P78508³, ENSP00000357068⁴	I2D: score=1 STRING: ENSP00000357068
KCNJ15	Q99712³, ENSP00000331698⁴	I2D: score=1 STRING: ENSP00000331698
DLG4	P78352³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	NAS	11060447
GO:0007268	synaptic transmission	TAS	--

KCNJ16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNJ16 available from Tocris Bioscience About this table

Compound	Action	CAS #
Tertiapin-Q	Selective blocker of inward-rectifier K+ channels	[252198-49-5]

1 HMDB Compound for KCNJ16 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about KCNJ16 / IRK16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNJ16 gene (4 alternative transcripts):

NM_001270422.1 NM_018658.2 NM_170741.2 NM_170742.1

Unigene Cluster for KCNJ16:

Potassium inwardly-rectifying channel, subfamily J, member 16

Hs.463985 [show with all ESTs]

Unigene Representative Sequence: NM_001270422

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591891 ENST00000588112 ENST00000589377 ENST00000586462 ENST00000585558

ENST00000587698 ENST00000587892 ENST00000283936(uc002jin.3) ENST00000392671(uc002jio.3 uc002jiq.3)

ENST00000392670(uc002jip.3)

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		hsa-miR-548p hsa-miR-302f hsa-miR-3156-5p hsa-miR-32* hsa-miR-4309 hsa-miR-340 hsa-miR-3182
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Additional cDNA sequence:

AF153815.1 AF153816.1 AF153817.1 AF179353.1 AK225944.1 AK290799.1 BC033038.2

8 DOTS entries:

DT.314490 DT.100747413 DT.95370381 DT.121011065 DT.121011080 DT.121011067 DT.75181134 DT.91858856

24/107 AceView cDNA sequences (see all 107):

AF153817 BF197355 AW271344 AI672450 AF179353 NM_018658 AI092303 AI949950

AI470911 BE167251 AI363102 AI217331 AI051637 AW611744 AA748747 AI925563

AF153816 AF153815 NM_170742 BX092587 AI418849 AI419663 AI151022 NM_170741

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ16 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f
SP1:																			-				-
SP2:											-		-		-		-		-
SP3:											-		-		-		-		-				-				-
SP4:
SP5:																			-				-				-

ECgene alternative splicing isoforms for KCNJ16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNJ16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAATAAACA

About this image

KCNJ16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Floor Plate

Floor Plate Cells

Neural Ectoderm

Spinal Cord

Spinal Floor Plate

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Midbrain dopaminergic-like neurons (Generation of midbra...)

See KCNJ16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ16

SOURCE GeneReport for Unigene cluster: Hs.463985

UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9

Tissue specificity: Highly expressed in kidney, pancreas and thyroid gland

SABiosciences Expression via Pathway-Focused PCR Array including KCNJ16:

Neuronal Ion Channels in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNJ16 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNJ16¹	potassium inwardly-rectifying channel, subfamily J, more	71.38(n) 76.61(a)		427812 XM_425383.1 XP_425383.1
lizard (Anolis carolinensis)	Reptilia	KCNJ16⁶	--	72(a)	1 ↔ 1	GL343258.1(2027364-2028542)
African clawed frog (Xenopus laevis)	Amphibia	BC042221.1²	--	73.94(n)		BC042221.1
zebrafish (Danio rerio)	Actinopterygii	LOC100001432¹	inward rectifier potassium channel 16-like	57.51(n) 48.27(a)		100001432 XM_001341392.4 XP_001341428.4
fruit fly (Drosophila melanogaster)	Insecta	Irk2⁶ Ir⁶ (see all 3)	Inwardly rectifying potassium channel (see all 3)	31(a) 25(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3R(19339690-19345167) 3R(18999595-19011364)
worm (Caenorhabditis elegans)	Secernentea	irk-2⁶ irk-3⁶ (see all 3)	Inward Rectifying K (potassium) channel family mem... Inward Rectifying K (potassium) channel family mem... (see all 3)	27(a) 26(a) (see all 3)	possible ortholog possible ortholog (see all 3)	X(702973-710006) X(14353239-14358995)

ENSEMBL Gene Tree for KCNJ16 (if available)
TreeFam Gene Tree for KCNJ16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNJ16 gene

KCNJ4² KCNJ9² KCNJ8² KCNJ1² KCNJ15² KCNJ12² KCNJ5² KCNJ6²

KCNJ2² KCNJ10² KCNJ14² KCNJ3² KCNJ11²

16 SIMAP similar genes for KCNJ16 using alignment to 6 protein entries: IRK16_HUMAN (see all proteins):

KCNJ12 KCNJ6 kcnj12x KCNJ18 KCNJ5 KCNJ4

KCNJ2 KCNJ1 KCNJ9 KCNJ11 KCNJ3 KCNJ14

KCNJ10 KCNJ8 KCNJ15 KCNJ13

KCNJ16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61296926^1,2	C	--	68079507(+)	`TGTATGTAT/- ATACA`	3	--	int¹		1		NA	2
rs138383684^1,2	C,	--	68083076(+)	`ACTCTA/GTCACC`	1	--	int¹		0	--	--	--	--
rs11657186^1,2	C,H,	--	68083133(+)	`CTCCCA/GGGTTC`	1	--	int¹		4		NA WA CSA	8
rs11657472^1,2	C,H,	--	68083164(+)	`CCCCCT/CGAGTA`	1	--	int¹		3		NA WA CSA	6
rs11653928^1,2	C,H,	--	68083298(+)	`CCTGCC/TTCGGC`	1	--	int¹		6		NA WA CSA	9
rs184884040^1,2		--	68083326(+)	`TTATAA/GACATT`	1	--	int¹		0	--	--	--	--
rs149539978^1,2		--	68083369(+)	`GGAAGA/TGGTAG`	1	--	int¹		0	--	--	--	--
rs10524283^1,2	C,	--	68087139(+)	`ACTTCTCTTA/- TATGA`	3	--	int¹		1		CSA	2
rs10535687^1,2	C	--	68087140(+)	`CTTCT-/CTTAT ATGAC`	3	--	int¹		1		NA	2
rs61699534^1,2	C	--	68087746(+)	`CACAC-/ACCACTC`	1	--	int¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for KCNJ16 (68049570 - 68131749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KCNJ16
2 CNVs: 0211 35485

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KCNJ16 for disorders           About GeneDecksing

OMIM gene information: 605722    OMIM disorders: --

4 diseases for KCNJ16:    About MalaCards

pierre robin sequence meniere's disease menieres disease thyroiditis

2 diseases from the University of Copenhagen DISEASES database for KCNJ16:

Body dysmorphic disorder Sensorineural hearing loss

Human Genome Epidemiology (HuGE) Navigator: KCNJ16 (2 documents)

Export disorders for KCNJ16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KCNJ16 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with KCNJ16)

Utopia: connect your pdf to the dynamic
world of online information

Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. (PubMed id 11240146)^{1, 2, 3, 9} Derst C.... Karschin A. (2001)
The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. (PubMed id 11060447)^{1, 2, 9} Liu Y.... Swanson R. (2000)
International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{1, 3} Kubo Y....Vandenberg C.A. (2005)
Genome-wide association study identifies a susceptibil ity locus for thyrotoxic periodic paralysis at 17q24.3. (PubMed id 22863731)¹ Cheung C.L....Kung A.W. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)¹ Lango Allen H....Hirschhorn J.N. (2010)
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. (PubMed id 19234473)¹ Benko S....Lyonnet S. (2009)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)¹ Ji W....Lifton R.P. (2008)
Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. (PubMed id 17185339)¹ Fowler C.E....Slesinger P.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3773	HGNC: 6262	AceView: KCNJ16	Ensembl:ENSG00000153822	euGenes: HUgn3773
ECgene: KCNJ16	Kegg: 3773	H-InvDB: KCNJ16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KCNJ16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNJ16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KCNJ16 gene:
Search GeneIP for patents involving KCNJ16

GeneCards and IP:
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