Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNJ16 Gene

Aliases for KCNJ16 Gene

  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 16 2 3
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 16 3 4
  • Inward Rectifier K(+) Channel Kir5.1 3 4
  • KIR5.1 3 6
  • Inward Rectifier Potassium Channel 16 3
  • Inward Rectifier K+ Channel KIR5.1 3
  • BIR9 3

External Ids for KCNJ16 Gene

Summaries for KCNJ16 Gene

Entrez Gene Summary for KCNJ16 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for KCNJ16 Gene

KCNJ16 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 16) is a Protein Coding gene. Diseases associated with KCNJ16 include body dysmorphic disorder and thyrotoxic periodic paralysis. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ16 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance

Tocris Summary for KCNJ16 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ16 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ16 Gene

Genomics for KCNJ16 Gene

Genomic Location for KCNJ16 Gene

Start:
70,053,429 bp from pter
End:
70,135,608 bp from pter
Size:
82,180 bases
Orientation:
Plus strand

Genomic View for KCNJ16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNJ16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ16 Gene

Regulatory Elements for KCNJ16 Gene

Proteins for KCNJ16 Gene

  • Protein details for KCNJ16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI9-KCJ16_HUMAN
    Recommended name:
    Inward rectifier potassium channel 16
    Protein Accession:
    Q9NPI9
    Secondary Accessions:

    Protein attributes for KCNJ16 Gene

    Size:
    418 amino acids
    Molecular mass:
    47949 Da
    Quaternary structure:
    • Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2

neXtProt entry for KCNJ16 Gene

Proteomics data for KCNJ16 Gene at MOPED

Post-translational modifications for KCNJ16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNJ16 Gene

Domains for KCNJ16 Gene

Gene Families for KCNJ16 Gene

HGNC:
  • KCN :Potassium channels
  • KCNJ :Voltage-gated ion channels / Potassium channels, Inwardly rectifying
IUPHAR :

UniProtKB/Swiss-Prot:

KCJ16_HUMAN
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.:
    • Q9NPI9
genes like me logo Genes that share domains with KCNJ16: view

Function for KCNJ16 Gene

Molecular function for KCNJ16 Gene

UniProtKB/Swiss-Prot Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance

Gene Ontology (GO) - Molecular Function for KCNJ16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity NAS 11060447
genes like me logo Genes that share ontologies with KCNJ16: view
genes like me logo Genes that share phenotypes with KCNJ16: view

Animal Models for KCNJ16 Gene

MGI Knock Outs for KCNJ16:

miRNA for KCNJ16 Gene

miRTarBase miRNAs that target KCNJ16

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KCNJ16 Gene

Localization for KCNJ16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ16 Gene COMPARTMENTS Subcellular localization image for KCNJ16 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNJ16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0008076 voltage-gated potassium channel complex NAS 11060447
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNJ16: view

Pathways for KCNJ16 Gene

genes like me logo Genes that share pathways with KCNJ16: view

Gene Ontology (GO) - Biological Process for KCNJ16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport NAS 11060447
GO:0007268 synaptic transmission TAS --
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IBA --
GO:0071805 potassium ion transmembrane transport --
genes like me logo Genes that share ontologies with KCNJ16: view

Compounds for KCNJ16 Gene

(5) Tocris Compounds for KCNJ16 Gene

Compound Action Cas Number
Diazoxide Blocks desensitization of AMPA receptors [364-98-7]
Glibenclamide Kir6 (KATP) channel blocker [10238-21-8]
Levcromakalim Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377) [94535-50-9]
P1075 Potent Kir6 (KATP) channel opener [60559-98-0]
Tertiapin-Q Selective blocker of inward-rectifier K+ channels [252198-49-5]

(1) HMDB Compounds for KCNJ16 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with KCNJ16: view

Transcripts for KCNJ16 Gene

Unigene Clusters for KCNJ16 Gene

Potassium inwardly-rectifying channel, subfamily J, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4:
SP5: - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - -

Relevant External Links for KCNJ16 Gene

GeneLoc Exon Structure for
KCNJ16
ECgene alternative splicing isoforms for
KCNJ16

Expression for KCNJ16 Gene

mRNA expression in normal human tissues for KCNJ16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNJ16 Gene

This gene is overexpressed in Thyroid (14.4), Kidney - Cortex (13.0), and Pancreas (5.7).

SOURCE GeneReport for Unigene cluster for KCNJ16 Gene Hs.463985

mRNA Expression by UniProt/SwissProt for KCNJ16 Gene

Q9NPI9-KCJ16_HUMAN
Tissue specificity: Highly expressed in kidney, pancreas and thyroid gland
genes like me logo Genes that share expressions with KCNJ16: view

Orthologs for KCNJ16 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ16 36
  • 99.12 (n)
  • 99.52 (a)
KCNJ16 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNJ16 36
  • 77.11 (n)
  • 89.71 (a)
KCNJ16 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNJ16 36
  • 89 (n)
  • 95.93 (a)
KCNJ16 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnj16 36
  • 84.45 (n)
  • 92.34 (a)
Kcnj16 16
Kcnj16 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ16 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ16 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj16 36
  • 83.41 (n)
  • 92.58 (a)
chicken
(Gallus gallus)
Aves KCNJ16 36
  • 71.38 (n)
  • 76.61 (a)
KCNJ16 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNJ16 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj16 36
  • 65.54 (n)
  • 67.1 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNJ16 37
  • 47 (a)
OneToOne
LOC100001432 36
  • 57.42 (n)
  • 48.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ir 37
  • 27 (a)
ManyToMany
Irk2 37
  • 32 (a)
ManyToMany
Species with no ortholog for KCNJ16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNJ16 Gene

ENSEMBL:
Gene Tree for KCNJ16 (if available)
TreeFam:
Gene Tree for KCNJ16 (if available)

Paralogs for KCNJ16 Gene

genes like me logo Genes that share paralogs with KCNJ16: view

Variants for KCNJ16 Gene

Sequence variations from dbSNP and Humsavar for KCNJ16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6788 -- 70,135,385(+) GCTAC(C/T)GCTGA utr-variant-3-prime
rs724589 -- 70,080,864(-) TTTGA(G/T)GTCCA intron-variant
rs724590 -- 70,080,415(-) GGATA(A/T)ATAGT intron-variant
rs724591 -- 70,080,807(-) TTCCC(A/G)AAGTA intron-variant
rs724824 -- 70,099,478(+) GGTAA(G/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ16 Gene

Variant ID Type Subtype PubMed ID
nsv483015 CNV Loss 15286789
nsv833528 CNV Loss 17160897
nsv2131 CNV Loss 18451855
nsv498875 CNV Loss 21111241
esv2666209 CNV Deletion 23128226
dgv563e199 CNV Deletion 23128226
nsv828096 CNV Loss 20364138
nsv526271 CNV Loss 19592680
nsv520048 CNV Loss 19592680

Relevant External Links for KCNJ16 Gene

HapMap Linkage Disequilibrium report
KCNJ16
Human Gene Mutation Database (HGMD)
KCNJ16

Disorders for KCNJ16 Gene

(2) University of Copenhagen DISEASES for KCNJ16 Gene

Relevant External Links for KCNJ16

Genetic Association Database (GAD)
KCNJ16
Human Genome Epidemiology (HuGE) Navigator
KCNJ16
genes like me logo Genes that share disorders with KCNJ16: view

No data available for UniProtKB/Swiss-Prot for KCNJ16 Gene

Publications for KCNJ16 Gene

  1. Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. (PMID: 11240146) Derst C. … Karschin A. (FEBS Lett. 2001) 2 3 4 23
  2. The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. (PMID: 11060447) Liu Y. … Swanson R. (Cytogenet. Cell Genet. 2000) 3 4 23
  3. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for KCNJ16 Gene

Sources for KCNJ16 Gene

Back to Top

Content