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Aliases for KCNJ15 Gene

Aliases for KCNJ15 Gene

  • Potassium Voltage-Gated Channel Subfamily J Member 15 2 3
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 15 3 5
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
  • Inward Rectifier K(+) Channel Kir1.3 3 4
  • Inward Rectifier K(+) Channel Kir4.2 3 4
  • Inward Rectifier K+ Channel KIR4.2 3
  • KIR1.3 3
  • KIR4.2 3
  • KCNJ14 4
  • IRKK 3

External Ids for KCNJ15 Gene

Previous GeneCards Identifiers for KCNJ15 Gene

  • GC21P036206
  • GC21P036289
  • GC21P038549
  • GC21P038550
  • GC21P039628
  • GC21P025098
  • GC21P039529

Summaries for KCNJ15 Gene

Entrez Gene Summary for KCNJ15 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KCNJ15 Gene

KCNJ15 (Potassium Voltage-Gated Channel Subfamily J Member 15) is a Protein Coding gene. Diseases associated with KCNJ15 include Corneal Dystrophy, Schnyder Type. Among its related pathways are Inwardly rectifying K+ channels and Transmission across Chemical Synapses. GO annotations related to this gene include potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ15 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Tocris Summary for KCNJ15 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Gene Wiki entry for KCNJ15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ15 Gene

Genomics for KCNJ15 Gene

Regulatory Elements for KCNJ15 Gene

Enhancers for KCNJ15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNJ15 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNJ15 Gene

Chromosome:
21
Start:
38,157,034 bp from pter
End:
38,307,357 bp from pter
Size:
150,324 bases
Orientation:
Plus strand

Genomic View for KCNJ15 Gene

Genes around KCNJ15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNJ15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNJ15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ15 Gene

Proteins for KCNJ15 Gene

  • Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99712-KCJ15_HUMAN
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Protein Accession:
    Q99712
    Secondary Accessions:
    • D3DSH5
    • O00564
    • Q96L28
    • Q99446

    Protein attributes for KCNJ15 Gene

    Size:
    375 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    • Interacts with INADL.

neXtProt entry for KCNJ15 Gene

Proteomics data for KCNJ15 Gene at MOPED

Post-translational modifications for KCNJ15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNJ15 Gene

Domains & Families for KCNJ15 Gene

Gene Families for KCNJ15 Gene

Suggested Antigen Peptide Sequences for KCNJ15 Gene

Graphical View of Domain Structure for InterPro Entry

Q99712

UniProtKB/Swiss-Prot:

KCJ15_HUMAN :
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
genes like me logo Genes that share domains with KCNJ15: view

Function for KCNJ15 Gene

Molecular function for KCNJ15 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
UniProtKB/Swiss-Prot Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
genes like me logo Genes that share phenotypes with KCNJ15: view

Animal Models for KCNJ15 Gene

MGI Knock Outs for KCNJ15:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNJ15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNJ15 Gene

Localization for KCNJ15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ15 Gene COMPARTMENTS Subcellular localization image for KCNJ15 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNJ15: view

Pathways & Interactions for KCNJ15 Gene

genes like me logo Genes that share pathways with KCNJ15: view

Gene Ontology (GO) - Biological Process for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA,TAS 8995301
genes like me logo Genes that share ontologies with KCNJ15: view

No data available for SIGNOR curated interactions for KCNJ15 Gene

Drugs & Compounds for KCNJ15 Gene

(5) Drugs for KCNJ15 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved Pharma Antagonist, Target 25
Diazoxide Approved Pharma Activator Blocks desensitization of AMPA receptors 21
Minoxidil Approved Pharma Activator Kir6 channel (KATP) opener 34
Magnesium Nutra 0
Cromakalim Pharma Activator Kir6 (KATP) channel opener 0

(2) Additional Compounds for KCNJ15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
P1075
60559-98-0
ZM 226600
147695-92-9

(5) Tocris Compounds for KCNJ15 Gene

Compound Action Cas Number
Cromakalim Kir6 (KATP) channel opener 94470-67-4
Diazoxide Blocks desensitization of AMPA receptors 364-98-7
Minoxidil Kir6 channel (KATP) opener 38304-91-5
P1075 Potent Kir6 (KATP) channel opener 60559-98-0
ZM 226600 Kir6 (KATP) channel opener 147695-92-9
genes like me logo Genes that share compounds with KCNJ15: view

Transcripts for KCNJ15 Gene

Unigene Clusters for KCNJ15 Gene

Potassium inwardly-rectifying channel, subfamily J, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for KCNJ15 Gene

GeneLoc Exon Structure for
KCNJ15
ECgene alternative splicing isoforms for
KCNJ15

Expression for KCNJ15 Gene

mRNA expression in normal human tissues for KCNJ15 Gene

mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene

This gene is overexpressed in Whole Blood (x26.9) and Kidney - Cortex (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ15 Gene



SOURCE GeneReport for Unigene cluster for KCNJ15 Gene Hs.411299

genes like me logo Genes that share expression patterns with KCNJ15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KCNJ15 Gene

Orthologs for KCNJ15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNJ15 35
  • 89.07 (n)
  • 97.07 (a)
KCNJ15 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNJ15 35
  • 90.4 (n)
  • 98.4 (a)
KCNJ15 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnj15 35
  • 85.78 (n)
  • 96.27 (a)
Kcnj15 16
Kcnj15 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNJ15 35
  • 99.82 (n)
  • 100 (a)
KCNJ15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj15 35
  • 86.22 (n)
  • 96.27 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNJ15 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ15 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNJ15 35
  • 78.04 (n)
  • 85.6 (a)
KCNJ15 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNJ15 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj15 35
  • 70.77 (n)
  • 74.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68935 35
zebrafish
(Danio rerio)
Actinopterygii LOC572476 35
  • 65.74 (n)
  • 63.27 (a)
KCNJ15 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Irk3 37
  • 34 (a)
Ir 36
  • 24 (a)
ManyToMany
Irk2 36
  • 29 (a)
ManyToMany
Species with no ortholog for KCNJ15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNJ15 Gene

ENSEMBL:
Gene Tree for KCNJ15 (if available)
TreeFam:
Gene Tree for KCNJ15 (if available)

Paralogs for KCNJ15 Gene

genes like me logo Genes that share paralogs with KCNJ15: view

Variants for KCNJ15 Gene

Sequence variations from dbSNP and Humsavar for KCNJ15 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2230033 - 38,299,554(+) ACCCG(A/G)TGAGC reference, missense
rs3746875 - 38,299,349(+) GCGTC(A/C)TGTCC reference, missense
rs199857043 A breast cancer sample 38,299,472(+) TGTTC(A/G)CTGCC reference, missense
rs2251360 -- 38,277,627(+) GAGCG(A/G)GTGCA intron-variant
rs2298331 -- 38,300,933(+) ATAGT(A/C)ATTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNJ15 Gene

Variant ID Type Subtype PubMed ID
nsv3514 CNV Insertion 18451855
esv2677092 CNV Deletion 23128226
esv22065 CNV Loss 19812545
esv33823 CNV Loss 17666407
nsv819873 CNV Loss 19587683

Variation tolerance for KCNJ15 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNJ15 Gene

Human Gene Mutation Database (HGMD)
KCNJ15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ15 Gene

Disorders for KCNJ15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNJ15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, schnyder type
  • schnyder corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCNJ15

Genetic Association Database (GAD)
KCNJ15
Human Genome Epidemiology (HuGE) Navigator
KCNJ15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNJ15
genes like me logo Genes that share disorders with KCNJ15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNJ15 Gene

Publications for KCNJ15 Gene

  1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P. … Creau N. (Genomics 1997) 2 3 4 23 67
  2. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3
  3. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. (PMID: 11804844) Hill C.E. … Magtanong L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002) 3 23
  4. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck M.E. … Bienkowski M.J. (J. Biol. Chem. 1997) 2 3
  5. Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion. (PMID: 26108660) Yuan J. … Zhu L. (Am. J. Physiol., Cell Physiol. 2015) 3

Products for KCNJ15 Gene

Sources for KCNJ15 Gene

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