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Aliases for KCNJ15 Gene

Aliases for KCNJ15 Gene

  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 15 2 3
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
  • Inward Rectifier K(+) Channel Kir1.3 3 4
  • Inward Rectifier K(+) Channel Kir4.2 3 4
  • ATP-Sensitive Inward Rectifier Potassium Channel 15 3
  • Inward Rectifier K+ Channel KIR4.2 3
  • KIR1.3 3
  • KIR4.2 3
  • KCNJ14 4
  • IRKK 3

External Ids for KCNJ15 Gene

Summaries for KCNJ15 Gene

Entrez Gene Summary for KCNJ15 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KCNJ15 Gene

KCNJ15 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 15) is a Protein Coding gene. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ15 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Tocris Summary for KCNJ15 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ15 Gene

Genomics for KCNJ15 Gene

Genomic Location for KCNJ15 Gene

Start:
38,157,034 bp from pter
End:
38,307,357 bp from pter
Size:
150,324 bases
Orientation:
Plus strand

Genomic View for KCNJ15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNJ15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ15 Gene

Regulatory Elements for KCNJ15 Gene

Proteins for KCNJ15 Gene

  • Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99712-KCJ15_HUMAN
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Protein Accession:
    Q99712
    Secondary Accessions:
    • D3DSH5
    • O00564
    • Q96L28
    • Q99446

    Protein attributes for KCNJ15 Gene

    Size:
    375 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    • Interacts with INADL.

neXtProt entry for KCNJ15 Gene

Proteomics data for KCNJ15 Gene at MOPED

Post-translational modifications for KCNJ15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNJ15 Gene

Domains for KCNJ15 Gene

Gene Families for KCNJ15 Gene

HGNC:
  • KCN :Potassium channels
  • KCNJ :Voltage-gated ion channels / Potassium channels, Inwardly rectifying
IUPHAR :

UniProtKB/Swiss-Prot:

KCJ15_HUMAN
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.:
    • Q99712
genes like me logo Genes that share domains with KCNJ15: view

Function for KCNJ15 Gene

Molecular function for KCNJ15 Gene

GENATLAS Biochemistry: potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
UniProtKB/Swiss-Prot Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Gene Ontology (GO) - Molecular Function for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity IEA --
GO:0005267 potassium channel activity --
GO:0005515 protein binding IPI 9647694
genes like me logo Genes that share ontologies with KCNJ15: view

Phenotypes for KCNJ15 Gene

genes like me logo Genes that share phenotypes with KCNJ15: view

miRNA for KCNJ15 Gene

miRTarBase miRNAs that target KCNJ15

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNJ15 Gene

Localization for KCNJ15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ15 Gene COMPARTMENTS Subcellular localization image for KCNJ15 gene
Compartment Confidence
plasma membrane 4
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8995301
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNJ15: view

Pathways for KCNJ15 Gene

genes like me logo Genes that share pathways with KCNJ15: view

Gene Ontology (GO) - Biological Process for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 8995301
GO:0007268 synaptic transmission TAS --
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IBA --
GO:0071805 potassium ion transmembrane transport --
genes like me logo Genes that share ontologies with KCNJ15: view

Compounds for KCNJ15 Gene

(5) Tocris Compounds for KCNJ15 Gene

Compound Action Cas Number
Diazoxide Blocks desensitization of AMPA receptors [364-98-7]
Glibenclamide Kir6 (KATP) channel blocker [10238-21-8]
Levcromakalim Kir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377) [94535-50-9]
P1075 Potent Kir6 (KATP) channel opener [60559-98-0]
Tertiapin-Q Selective blocker of inward-rectifier K+ channels [252198-49-5]

(1) HMDB Compounds for KCNJ15 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with KCNJ15: view

Transcripts for KCNJ15 Gene

Unigene Clusters for KCNJ15 Gene

Potassium inwardly-rectifying channel, subfamily J, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for KCNJ15 Gene

GeneLoc Exon Structure for
KCNJ15
ECgene alternative splicing isoforms for
KCNJ15

Expression for KCNJ15 Gene

mRNA expression in normal human tissues for KCNJ15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene

This gene is overexpressed in Whole Blood (26.9) and Kidney - Cortex (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNJ15 Gene

SOURCE GeneReport for Unigene cluster for KCNJ15 Gene Hs.411299

genes like me logo Genes that share expressions with KCNJ15: view

Orthologs for KCNJ15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ15 36
  • 99.82 (n)
  • 100 (a)
KCNJ15 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNJ15 36
  • 89.07 (n)
  • 97.07 (a)
KCNJ15 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNJ15 36
  • 90.4 (n)
  • 98.4 (a)
KCNJ15 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnj15 36
  • 85.78 (n)
  • 96.27 (a)
Kcnj15 16
Kcnj15 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ15 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ15 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj15 36
  • 86.22 (n)
  • 96.27 (a)
chicken
(Gallus gallus)
Aves KCNJ15 36
  • 78.04 (n)
  • 85.6 (a)
KCNJ15 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNJ15 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68935 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj15 36
  • 70.77 (n)
  • 74.59 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNJ15 37
  • 59 (a)
OneToOne
LOC572476 36
  • 65.74 (n)
  • 63.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ir 37
  • 24 (a)
ManyToMany
Irk2 37
  • 29 (a)
ManyToMany
Irk3 38
  • 34 (a)
Species with no ortholog for KCNJ15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNJ15 Gene

ENSEMBL:
Gene Tree for KCNJ15 (if available)
TreeFam:
Gene Tree for KCNJ15 (if available)

Paralogs for KCNJ15 Gene

genes like me logo Genes that share paralogs with KCNJ15: view

Variants for KCNJ15 Gene

Sequence variations from dbSNP and Humsavar for KCNJ15 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs9963 -- 38,300,702(+) GCAAT(C/G)CTGAC utr-variant-3-prime
rs715079 -- 38,239,128(+) GAAGC(A/G)TTCAG intron-variant
rs715080 -- 38,239,300(+) ACCAC(A/G)ACAAG intron-variant
rs719838 -- 38,239,442(+) TCTGC(A/G)AAGCC intron-variant
rs743296 -- 38,272,924(+) TAAAA(C/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ15 Gene

Variant ID Type Subtype PubMed ID
nsv3514 CNV Insertion 18451855
esv2677092 CNV Deletion 23128226
esv22065 CNV Loss 19812545
esv33823 CNV Loss 17666407
nsv819873 CNV Loss 19587683

Relevant External Links for KCNJ15 Gene

HapMap Linkage Disequilibrium report
KCNJ15
Human Gene Mutation Database (HGMD)
KCNJ15

Disorders for KCNJ15 Gene

Relevant External Links for KCNJ15

Genetic Association Database (GAD)
KCNJ15
Human Genome Epidemiology (HuGE) Navigator
KCNJ15
genes like me logo Genes that share disorders with KCNJ15: view

No data available for UniProtKB/Swiss-Prot for KCNJ15 Gene

Publications for KCNJ15 Gene

  1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P. … Creau N. (Genomics 1997) 2 3 4 23
  2. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck M.E. … Bienkowski M.J. (J. Biol. Chem. 1997) 2 3 4
  3. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. (PMID: 11804844) Hill C.E. … Magtanong L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002) 3 23
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. (PMID: 9647694) Kurschner C. … Surmeier D.J. (Mol. Cell. Neurosci. 1998) 3 4

Products for KCNJ15 Gene

Sources for KCNJ15 Gene

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