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KCNJ15 Gene

protein-coding   GIFtS: 66
GCID: GC21P039529

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 151 2     KIR1.32
Inward Rectifier K(+) Channel Kir1.32 3     KIR4.22
Inward Rectifier K(+) Channel Kir4.22 3     ATP-Sensitive Inward Rectifier Potassium Channel 152
Potassium Channel, Inwardly Rectifying Subfamily J Member 152 3     Inward Rectifier K+ Channel KIR4.22
Inwardly Rectifing Potassium Channel Kir4.211     KCNJ143
IRKK2     

External Ids:    HGNC: 62611   Entrez Gene: 37722   Ensembl: ENSG000001575517   OMIM: 6021065   UniProtKB: Q997123   

Export aliases for KCNJ15 gene to outside databases

Previous GC identifers: GC21P036206 GC21P036289 GC21P038549 GC21P038550 GC21P039628 GC21P025098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNJ15 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a
cell. Eight transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Feb
2013)

GeneCards Summary for KCNJ15 Gene:
KCNJ15 (potassium inwardly-rectifying channel, subfamily J, member 15) is a protein-coding gene. Diseases associated with KCNJ15 include meniere's disease, and menieres disease. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular
potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

summary for KCNJ15 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNJ15 gene promoter:
         CREB   GR   ATF-2   GR-beta   IRF-7A   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ15 promoter sequence

   Search Chromatin IP Primers for KCNJ15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNJ15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.2
KCNJ15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ15 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P039529:   GeneLoc Nature:405,311-319
Start:
39,529,128 bp from pter       25,245,362 bp from centromere
End:
39,679,279 bp from pter 25,249,289 bp from centromere
Size:
150,152 bases 3,928 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Y10745
genomic clones: pT695 pS166


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712 (See protein sequence)
Recommended Name: ATP-sensitive inward rectifier potassium channel 15  
Size: 375 amino acids; 42577 Da
Subunit: Interacts with INADL
Secondary accessions: D3DSH5 O00564 Q96L28 Q99446

Explore the universe of human proteins at neXtProt for KCNJ15: NX_Q99712

Explore proteomics data for KCNJ15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNJ15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001263364.1  NP_001263365.1  NP_001263366.1  NP_001263367.1  NP_001263368.1  NP_002234.2  NP_733932.1  NP_733933.1  

    ENSEMBL proteins: 
     ENSP00000449140   ENSP00000448770   ENSP00000447111   ENSP00000448676   ENSP00000450254  
     ENSP00000448886   ENSP00000449419   ENSP00000381899   ENSP00000381902   ENSP00000331698  
     ENSP00000413013   ENSP00000392951   ENSP00000381911   ENSP00000381905   ENSP00000414487  
     ENSP00000381904   ENSP00000381901   ENSP00000400849   ENSP00000381907  
    Reactome Protein details: Q99712

    KCNJ15 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kir4.2
    Inwardly rectifying potassium channels

    4 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR013518 K_chnl_inward-rec_Kir_cyto
     IPR016449 K_chnl_inward-rec_Kir
     IPR003270 K_chnl_inward-rec_Kir1.3

    Graphical View of Domain Structure for InterPro Entry Q99712

    ProtoNet protein and cluster: Q99712

    2 Blocks protein domains:
    IPB001838 Inward rectifier K+ channel superfamily signature
    IPB003270 Kir1.3 inward rectifer K+ channel signature


    UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712
    Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily


    KCNJ15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRK15_HUMAN, Q99712
    Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow
    into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular
    potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive
    voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

         Genatlas biochemistry entry for KCNJ15:
    potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity IEA--
    GO:0005267potassium channel activity ----
    GO:0005515protein binding IPI9647694
         
    KCNJ15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNJ15:
     Decreased homologous recombina  Increased G2M DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnj15):
     behavior/neurological 

    KCNJ15 for phenotypes           About GeneDecksing

    Animal Models:
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    2 qRT-PCR Assays for microRNAs that regulate KCNJ15:
    hsa-miR-877* hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidKCNJ15 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRK15_HUMAN, Q99712: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8995301
    GO:0016021integral component of membrane ----

    KCNJ15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNJ15 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Inwardly rectifying K+ channels
    Inwardly rectifying K+ channels0.82
    G protein gated Potassium channels0.82
    Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.82
    Activation of G protein gated Potassium channels0.82
    2GABA receptor activation
    GABA B receptor activation0.73
    GABA receptor activation0.73
    Activation of GABAB receptors0.73
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Potassium Channels
    Potassium Channels0.43
    5Salivary secretion
    Gastric acid secretion0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNJ15
        Dopamine-DARPP32 Feedback onto cAMP Pathway


    2 Reactome Pathways for KCNJ15
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
    Activation of G protein gated Potassium channels


    1 Kegg Pathway  (Kegg details for KCNJ15):
        Gastric acid secretion


    KCNJ15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ15: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNJ15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for KCNJ15 (Q997121, 2, 3 ENSP000003316984) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    INADLQ8NI353, ENSP000003602004I2D: score=3 STRING: ENSP00000360200
    KCNJ16Q9NPI93, ENSP000002839364I2D: score=1 STRING: ENSP00000283936
    SNTA1Q134243I2D: score=1 
    InadlQ63ZW71, 2EBI-7082607,EBI-8366894 MINT-1891729 MINT-1891868 MINT-1891793 MINT-1891163
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8995301
    GO:0007268synaptic transmission TAS--
    GO:0071805potassium ion transmembrane transport ----

    KCNJ15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNJ15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
    DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
    GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
    P1075Potent Kir6 (KATP) channel opener[60559-98-0]
    Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

    1 HMDB Compound for KCNJ15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNJ15 gene (8 alternative transcripts): 
    NM_001276435.1  NM_001276436.1  NM_001276437.1  NM_001276438.1  NM_001276439.1  NM_002243.4  NM_170736.2  NM_170737.2  

    Unigene Cluster for KCNJ15:

    Potassium inwardly-rectifying channel, subfamily J, member 15
    Hs.411299  [show with all ESTs]
    Unigene Representative Sequence: NM_170736
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000549158 ENST00000549805 ENST00000547341 ENST00000549932 ENST00000547595
    ENST00000548700 ENST00000551422 ENST00000398925 ENST00000398928 ENST00000328656(uc002ywv.3 uc002yww.3)
    ENST00000443341 ENST00000417042 ENST00000398938 ENST00000398932 ENST00000438657
    ENST00000398930 ENST00000398927 ENST00000419868
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      QuantiFast Probe-based Assays in human, mouse, rat KCNJ15

    Additional mRNA sequence: 

    AK057957.1 AK092958.1 AK292812.1 BC013327.1 D87291.1 U73191.1 Y10745.1 

    13 DOTS entries:

    DT.100751733  DT.110376  DT.91662512  DT.97838437  DT.121140925  DT.121140945  DT.91649589  DT.99936056 
    DT.121140947  DT.92041440  DT.95282180  DT.121140906  DT.75160231 

    Selected AceView cDNA sequences (see all 67):

    BX117592 NM_170736 BE465763 BG288548 AA745676 AI961921 AI766814 NM_002243 
    BC013327 BI518753 BX093389 NM_170737 T94029 T94781 BU621569 BX110999 
    Y10745 AW467056 AI245812 U73191 AI963792 AI344546 D87291 AW242620 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:              -           -           -     -                                                         
    SP2:              -           -     -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                          -           -     -                                                         
    SP5:                          -     -     -     -                                                         


    ECgene alternative splicing isoforms for KCNJ15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNJ15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNJ15 Expression
    About this image


    KCNJ15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Ovary (Reproductive System)
             Oviduct
    KCNJ15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNJ15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411299
        Pathway & Disease-focused RT2 Profiler PCR Array including KCNJ15: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNJ15 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnj151 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 85.78(n)1
    96.27(a)1
      16 (55.86 cM)5
    165161  NM_001271692.11  NP_001258621.11 
     952575585 
    chicken
    (Gallus gallus)
    Aves KCNJ151 potassium inwardly-rectifying channel, subfamily J, more 78.04(n)
    85.6(a)
      427984  XM_004934549.1  XP_004934606.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNJ156
    potassium inwardly-rectifying channel, subfamily J...
    82(a)
    1 ↔ 1
    3(140302996-140304129)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689352 hypothetical protein MGC68935 75.54(n)    BC059301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5724761 ATP-sensitive inward rectifier potassium channel 15-like 65.74(n)
    63.27(a)
      572476  XM_005172574.1  XP_005172631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Irk33 inward rectifier potassium channel 34(a)   37A1   --


    ENSEMBL Gene Tree for KCNJ15 (if available)
    TreeFam Gene Tree for KCNJ15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNJ15 gene
    KCNJ42  KCNJ92  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ52  KCNJ62  
    KCNJ22  KCNJ102  KCNJ142  KCNJ32  KCNJ112  
    16 SIMAP similar genes for KCNJ15 using alignment to 9 protein entries:     IRK15_HUMAN (see all proteins):
    KCNJ1    KCNJ10    KCNJ5    KCNJ3    KCNJ6    KCNJ12
    KCNJ9    kcnj12x    KCNJ18    KCNJ2    KCNJ4    KCNJ14
    KCNJ11    KCNJ13    KCNJ8    KCNJ16

    KCNJ15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNJ15 (see all 1590)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364274
    A breast cancer sample4--see VAR_0364272 A T mis40--------
    rs1404588551,2
    Cuntested139671687(+) AAAATC/TGCCAG 16 I syn10--------
    rs724183271,2
    C--25125230(+) AAAAG-/TGAA  
            
    TTCCT
    8 -- int10--------
    rs1842625471,2
    C--39599950(+) AGTATA/GATAGA 3 -- us2k10--------
    rs1883972661,2
    C--39599973(+) TTTCCC/TGGGGA 3 -- us2k10--------
    rs1147040941,2
    C,F--39600002(+) GCATGG/ACCAGA 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1915117131,2
    --39600121(+) CTCCTC/TGGGGG 3 -- us2k10--------
    rs28362181,2
    C,F,O,A--39600143(+) aaaggT/Cgggta 3 -- us2k110Minor allele frequency- C:0.42NA WA CSA EA 383
    rs1433165031,2
    C--39600164(+) AGGGA-/GGA   
      G
    /GGGA
    GGATT
    3 -- us2k10--------
    rs2012822771,2
    C--39600167(+) GAGGA-/GGGA  
            
    TTCCT
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNJ15 (39529128 - 39679279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNJ15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677092CNV Deletion23128226
    nsv3514CNV Insertion18451855
    esv22065CNV Loss19812545
    nsv819873CNV Loss19587683
    esv33823CNV Loss17666407

    Human Gene Mutation Database (HGMD): KCNJ15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNJ15
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602106    OMIM disorders: --

    11 diseases for KCNJ15:    
    About MalaCards
    meniere's disease    menieres disease    down syndrome    breast and colorectal cancer
    diabetes mellitus    tonsillitis    colorectal cancer    thyroiditis
    neuronitis    endotheliitis    prostatitis


    KCNJ15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNJ15
    Human Genome Epidemiology (HuGE) Navigator: KCNJ15 (2 documents)

    Export disorders for KCNJ15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNJ15 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with KCNJ15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PubMed id 9299242)1, 2, 3, 9 Gosset P.... Creau N. (Genomics 1997)
    2. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PubMed id 8995301)1, 2, 3 Shuck M.E....Bienkowski M.J. (J. Biol. Chem. 1997)
    3. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (PubMed id 20085713)1, 4 Okamoto K....Tokunaga K. (Am. J. Hum. Genet. 2010)
    4. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (Pharmacol. Rev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. (PubMed id 9647694)1, 2 Kurschner C.... Surmeier D.J. (Mol. Cell. Neurosci. 1998)
    8. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. (PubMed id 11804844)1, 9 Hill C.E....Magtanong L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002)
    9. Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. (PubMed id 23595124)1 Fukuda H....Maeda S. (J. Hum. Genet. 2013)
    10. Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. (PubMed id 22566534)1 Okamoto K....Tokunaga K. (Diabetes 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3772 HGNC: 6261 AceView: KCNJ15 Ensembl:ENSG00000157551 euGenes: HUgn3772
    ECgene: KCNJ15 Kegg: 3772 H-InvDB: KCNJ15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNJ15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNJ15 gene:
    Search GeneIP for patents involving KCNJ15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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