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Aliases for KCNJ15 Gene

Aliases for KCNJ15 Gene

  • Potassium Voltage-Gated Channel Subfamily J Member 15 2 3 5
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
  • Inward Rectifier K(+) Channel Kir1.3 3 4
  • Inward Rectifier K(+) Channel Kir4.2 3 4
  • ATP-Sensitive Inward Rectifier Potassium Channel 15 3
  • Inward Rectifier K+ Channel KIR4.2 3
  • KIR1.3 3
  • KIR4.2 3
  • KCNJ14 4
  • IRKK 3

External Ids for KCNJ15 Gene

Previous GeneCards Identifiers for KCNJ15 Gene

  • GC21P036206
  • GC21P036289
  • GC21P038549
  • GC21P038550
  • GC21P039628
  • GC21P025098
  • GC21P039529

Summaries for KCNJ15 Gene

Entrez Gene Summary for KCNJ15 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KCNJ15 Gene

KCNJ15 (Potassium Voltage-Gated Channel Subfamily J Member 15) is a Protein Coding gene. Diseases associated with KCNJ15 include Corneal Dystrophy, Schnyder Type. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ10.

UniProtKB/Swiss-Prot for KCNJ15 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Tocris Summary for KCNJ15 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Gene Wiki entry for KCNJ15 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ15 Gene

Genomics for KCNJ15 Gene

Regulatory Elements for KCNJ15 Gene

Enhancers for KCNJ15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F038227 1.2 FANTOM5 ENCODE 32.1 +71.4 71367 1.5 E2F1 GATA3 CTBP1 BCL11A NBN DPF2 TRIM28 KCNJ15 GC21M038236 DSCR10
GH21F038348 1.5 FANTOM5 Ensembl ENCODE 19.6 +193.9 193922 5.2 HDGF ZNF143 ZNF207 FOS KLF7 ZNF263 SP3 TSHZ1 REST ZNF518A KCNJ15 BRWD1 LINC01423 ETS2 GC21M038398 GC21M038399
GH21F038180 0.4 ENCODE 18 +24.2 24191 1.3 KCNJ15 GC21P038167 LOC100288590
GH21F038257 1.7 FANTOM5 Ensembl ENCODE 17.3 +101.5 101524 3.1 CTCF JUND BHLHE40 FOS RAD21 MAFK NFE2L2 KCNJ15 SPATA20P1 LOC105372801
GH21F038239 0.8 Ensembl ENCODE 16.7 +84.4 84420 3.8 SIN3A ZNF335 CTBP1 GLIS2 ZFHX2 GATA3 ZBTB48 SCRT2 PATZ1 EGR2 KCNJ15 SPATA20P1 LOC105372801
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KCNJ15 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNJ15 Gene

Chromosome:
21
Start:
38,157,034 bp from pter
End:
38,307,357 bp from pter
Size:
150,324 bases
Orientation:
Plus strand

Genomic View for KCNJ15 Gene

Genes around KCNJ15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNJ15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNJ15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ15 Gene

Proteins for KCNJ15 Gene

  • Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99712-KCJ15_HUMAN
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Protein Accession:
    Q99712
    Secondary Accessions:
    • D3DSH5
    • O00564
    • Q96L28
    • Q99446

    Protein attributes for KCNJ15 Gene

    Size:
    375 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    • Interacts with PATJ.

neXtProt entry for KCNJ15 Gene

Post-translational modifications for KCNJ15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for KCNJ15
  • Santa Cruz Biotechnology (SCBT) Antibodies for KCNJ15

No data available for DME Specific Peptides for KCNJ15 Gene

Domains & Families for KCNJ15 Gene

Gene Families for KCNJ15 Gene

Suggested Antigen Peptide Sequences for KCNJ15 Gene

Graphical View of Domain Structure for InterPro Entry

Q99712

UniProtKB/Swiss-Prot:

KCJ15_HUMAN :
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
genes like me logo Genes that share domains with KCNJ15: view

Function for KCNJ15 Gene

Molecular function for KCNJ15 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
UniProtKB/Swiss-Prot Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Gene Ontology (GO) - Molecular Function for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 8995301
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005515 protein binding IPI 9647694
GO:0015467 G-protein activated inward rectifier potassium channel activity TAS --
genes like me logo Genes that share ontologies with KCNJ15: view
genes like me logo Genes that share phenotypes with KCNJ15: view

Animal Models for KCNJ15 Gene

MGI Knock Outs for KCNJ15:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNJ15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNJ15 Gene

Localization for KCNJ15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ15 Gene COMPARTMENTS Subcellular localization image for KCNJ15 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8995301
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNJ15: view

Pathways & Interactions for KCNJ15 Gene

genes like me logo Genes that share pathways with KCNJ15: view

Gene Ontology (GO) - Biological Process for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 8995301
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNJ15: view

No data available for SIGNOR curated interactions for KCNJ15 Gene

Drugs & Compounds for KCNJ15 Gene

(7) Drugs for KCNJ15 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Vet_approved Pharma Antagonist, Target 27
Glyburide Approved Pharma Channel blocker Kir6 (KATP) channel blocker 111
Nicorandil Approved Pharma Activator Potassium channel activator, Kir6 (KATP) channel opener and NO donor 17
Magnesium Nutra 0
Levcromakalim Pharma Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377) 0

(5) Tocris Compounds for KCNJ15 Gene

Compound Action Cas Number
Glibenclamide Kir6 (KATP) channel blocker 10238-21-8
Levcromakalim Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377) 94535-50-9
Nicorandil Kir6 (KATP) channel opener and NO donor 65141-46-0
Tertiapin-Q Selective blocker of inward-rectifier K+ channels 252198-49-5
Y-26763 Kir6 (KATP) channel opener 127408-31-5
genes like me logo Genes that share compounds with KCNJ15: view

Transcripts for KCNJ15 Gene

Unigene Clusters for KCNJ15 Gene

Potassium inwardly-rectifying channel, subfamily J, member 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for KCNJ15 Gene

GeneLoc Exon Structure for
KCNJ15
ECgene alternative splicing isoforms for
KCNJ15

Expression for KCNJ15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNJ15 Gene

mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene

This gene is overexpressed in Whole Blood (x26.9) and Kidney - Cortex (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ15 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCNJ15 Gene:

KCNJ15

SOURCE GeneReport for Unigene cluster for KCNJ15 Gene:

Hs.411299
genes like me logo Genes that share expression patterns with KCNJ15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KCNJ15 Gene

Orthologs for KCNJ15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ15 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia KCNJ15 34 35
  • 90.4 (n)
cow
(Bos Taurus)
Mammalia KCNJ15 34 35
  • 89.07 (n)
rat
(Rattus norvegicus)
Mammalia Kcnj15 34
  • 86.22 (n)
mouse
(Mus musculus)
Mammalia Kcnj15 34 16 35
  • 85.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ15 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ15 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNJ15 34 35
  • 78.04 (n)
lizard
(Anolis carolinensis)
Reptilia KCNJ15 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj15 34
  • 70.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68935 34
zebrafish
(Danio rerio)
Actinopterygii LOC572476 34
  • 65.74 (n)
KCNJ15 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Irk3 36
  • 34 (a)
Irk2 35
  • 29 (a)
ManyToMany
Ir 35
  • 24 (a)
ManyToMany
Species where no ortholog for KCNJ15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNJ15 Gene

ENSEMBL:
Gene Tree for KCNJ15 (if available)
TreeFam:
Gene Tree for KCNJ15 (if available)

Paralogs for KCNJ15 Gene

Variants for KCNJ15 Gene

Sequence variations from dbSNP and Humsavar for KCNJ15 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs199857043 A breast cancer sample 38,299,472(+) TGTTC(A/G)CTGCC reference, missense
rs1004850 -- 38,268,569(+) aaaaa(A/G)aaaaa intron-variant
rs1009207 -- 38,271,744(+) CATTG(C/T)TCCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1041721 -- 38,277,171(+) AGACT(C/T)GGCAT intron-variant
rs10483043 -- 38,254,654(+) AAAAT(G/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ15 Gene

Variant ID Type Subtype PubMed ID
esv22065 CNV loss 19812545
esv2677092 CNV deletion 23128226
esv33823 CNV loss 17666407
esv3387523 CNV insertion 20981092
esv3389609 CNV insertion 20981092
esv3647000 CNV loss 21293372
nsv1058886 CNV gain 25217958
nsv3514 CNV insertion 18451855
nsv474591 CNV novel sequence insertion 20440878
nsv819873 CNV loss 19587683

Variation tolerance for KCNJ15 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNJ15 Gene

Human Gene Mutation Database (HGMD)
KCNJ15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNJ15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ15 Gene

Disorders for KCNJ15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNJ15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, schnyder type
  • schnyder corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCNJ15

Genetic Association Database (GAD)
KCNJ15
Human Genome Epidemiology (HuGE) Navigator
KCNJ15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNJ15
genes like me logo Genes that share disorders with KCNJ15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNJ15 Gene

Publications for KCNJ15 Gene

  1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P. … Creau N. (Genomics 1997) 2 3 4 22 64
  2. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck M.E. … Bienkowski M.J. (J. Biol. Chem. 1997) 2 3 4 64
  3. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (PMID: 20085713) Okamoto K. … Tokunaga K. (Am. J. Hum. Genet. 2010) 3 46 64
  4. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for KCNJ15 Gene

Sources for KCNJ15 Gene

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