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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNJ15 Gene

protein-coding   GIFtS: 64
GCID: GC21P039529

potassium inwardly-rectifying channel, subfamily J, member...
 Explore 6 diseases affiliated with
KCNJ15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNJ15    

Aliases
for KCNJ15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 151 2     Inwardly Rectifing Potassium Channel Kir4.211
IRKK1 2     KIR1.32
Inward Rectifier K(+) Channel Kir1.32 3     KIR4.22
Inward Rectifier K(+) Channel Kir4.22 3     ATP-Sensitive Inward Rectifier Potassium Channel 152
Potassium Channel, Inwardly Rectifying Subfamily J Member 152 3     Inward Rectifier K+ Channel KIR4.22
Kir1.31     KCNJ143
Kir4.21     

External Ids:    HGNC: 62611   Entrez Gene: 37722   Ensembl: ENSG000001575517   OMIM: 6021065   UniProtKB: Q997123   

Export aliases for KCNJ15 gene to outside databases

Previous GC identifers: GC21P036206 GC21P036289 GC21P038549 GC21P038550 GC21P039628 GC21P025098


Summaries
for KCNJ15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNJ15:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell.
Eight transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Feb 2013)

UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into
the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;
as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward
rectification is mainly due to the blockage of outward current by internal magnesium

summary for KCNJ15:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ15


Genomic Views
for KCNJ15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNJ15 gene promoter:
         CREB   GR   ATF-2   GR-beta   IRF-7A   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNJ15 promoter sequence

   Search SABiosciences Chromatin IP Primers for KCNJ15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.2
KCNJ15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ15 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P039529:   GeneLoc Nature:405,311-319
Start:
 39,529,128 bp from pter       25,245,362 bp from centromere
End:
 39,673,748 bp from pter 25,249,289 bp from centromere
Size:
 144,621 bases 3,928 bases
Orientation:
 plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Y10745
genomic clones: pT695 pS166


Proteins
for KCNJ15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712 (See protein sequence)
Recommended Name: ATP-sensitive inward rectifier potassium channel 15  
Size: 375 amino acids; 42577 Da
Subunit: Interacts with INADL
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: D3DSH5 O00564 Q96L28 Q99446

Explore the universe of human proteins at neXtProt for KCNJ15: NX_Q99712

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99712

    • KCNJ15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_001263364.1  NP_001263365.1  NP_001263366.1  NP_001263367.1  NP_001263368.1  NP_002234.2  NP_733932.1  NP_733933.1  

    ENSEMBL proteins: 
     ENSP00000449140   ENSP00000448770   ENSP00000447111   ENSP00000448676   ENSP00000450254  
     ENSP00000448886   ENSP00000449419   ENSP00000381899   ENSP00000381902   ENSP00000331698  
     ENSP00000413013   ENSP00000392951   ENSP00000381911   ENSP00000381905   ENSP00000414487  
     ENSP00000381904   ENSP00000381901   ENSP00000400849   ENSP00000381907  
    Reactome Protein details: Q99712
    Human Recombinant Protein Products: 
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    Uscn Proteins for KCNJ15

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8995301
    GO:0016021integral to membrane ----


    KCNJ15 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNJ15

    Protein Domains /
    Families
    for KCNJ15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNJ15 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR014756 Ig_E-set
     IPR013518 K_chnl_inward-rec_Kir_cyto
     IPR016449 K_chnl_inward-rec_Kir
     IPR003270 K_chnl_inward-rec_Kir1.3

    Graphical View of Domain Structure for InterPro Entry Q99712

    ProtoNet protein and cluster: Q99712

    2 Blocks protein families:
    IPB001838 Inward rectifier K+ channel superfamily signature
    IPB003270 Kir1.3 inward rectifer K+ channel signature


    UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712
    Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily


    Function
    for KCNJ15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRK15_HUMAN, Q99712
    Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into
    the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;
    as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward
    rectification is mainly due to the blockage of outward current by internal magnesium

         Genatlas biochemistry entry for KCNJ15:
    potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity IEA--
    GO:0005267potassium channel activity ----
    GO:0005515protein binding ----


    KCNJ15 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for KCNJ15:
     Decreased homologous recombina  Increased G2M DNA content 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnj15):
     behavior/neurological 

    KCNJ15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNJ15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Inwardly rectifying K+ channels
    		Inwardly rectifying K+ channels1.00
    		G protein gated Potassium channels0.81
    		Activation of G protein gated Potassium channels0.81
    		Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits0.81
    2Activation of GABAB receptors
    		Activation of GABAB receptors1.00
    		GABA receptor activation0.72
    		GABA B receptor activation1.00
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Potassium Channels
    		Potassium Channels1.00
    5Potassium transporters: inward current
    		Potassium transporters: inward current1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNJ15
        Potassium transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ15
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    5/11        Reactome Pathways for KCNJ15 (see all 11)
        Transmission across Chemical Synapses
    G protein gated Potassium channels
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
    Inwardly rectifying K+ channels


    1         Kegg Pathway  (Kegg details for KCNJ15):
        Gastric acid secretion


    KCNJ15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNJ15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for KCNJ15 (Q997122, 3 ENSP000003316984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    INADLQ8NI353, ENSP000003602004I2D: score=3 STRING: ENSP00000360200
    KCNJ16Q9NPI93, ENSP000002839364I2D: score=1 STRING: ENSP00000283936
    SNTA1Q134243I2D: score=1 
    --Q63ZW72MINT-1891729 MINT-1891868 MINT-1891793 MINT-1891163
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport TAS8995301
    GO:0007268synaptic transmission TAS--
    GO:0071805potassium ion transmembrane transport ----


    KCNJ15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNJ15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Compounds for KCNJ15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

    1 HMDB Compound for KCNJ15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about KCNJ15 / IRK15 

    Transcripts
    for KCNJ15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNJ15 gene (8 alternative transcripts): 
    NM_001276435.1  NM_001276436.1  NM_001276437.1  NM_001276438.1  NM_001276439.1  NM_002243.4  NM_170736.2  NM_170737.2  

    Unigene Cluster for KCNJ15:

    Potassium inwardly-rectifying channel, subfamily J, member 15
    Hs.411299  [show with all ESTs]
    Unigene Representative Sequence: NM_170736
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000549158 ENST00000549805 ENST00000547341 ENST00000549932 ENST00000547595
    ENST00000548700 ENST00000551422 ENST00000398925 ENST00000398928 ENST00000328656(uc002ywv.3 uc002yww.3)
    ENST00000443341 ENST00000417042 ENST00000398938 ENST00000398932 ENST00000438657
    ENST00000398930 ENST00000398927 ENST00000419868

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK057957.1 AK092958.1 AK292812.1 BC013327.1 D87291.1 U73191.1 Y10745.1 

    13 DOTS entries:

    DT.100751733  DT.110376  DT.91662512  DT.97838437  DT.121140925  DT.91649589  DT.121140945  DT.99936056 
    DT.121140947  DT.92041440  DT.95282180  DT.121140906  DT.75160231 

    24/67 AceView cDNA sequences (see all 67):

    BX117592 BC013327 BE465763 AA745676 NM_170737 NM_170736 BX093389 T94781 
    NM_002243 T94029 AI766814 AI961921 BG288548 BI518753 BU619585 D87291 
    AI344546 AA931111 AW242620 BX110999 BM544058 AI245812 BU617024 C01642 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:              -           -           -     -                                                         
    SP2:              -           -     -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                          -           -     -                                                         
    SP5:                          -     -     -     -                                                         


    ECgene alternative splicing isoforms for KCNJ15

    Expression
    for KCNJ15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNJ15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNJ15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNJ15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNJ15

    SOURCE GeneReport for Unigene cluster: Hs.411299
        SABiosciences Expression via Pathway-Focused PCR Array including KCNJ15: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Orthologs
    for KCNJ15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNJ15 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNJ151 potassium inwardly-rectifying channel, subfamily J, more 78.04(n)
    85.6(a)    		   427984  XM_425554.3  XP_425554.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNJ156
    		 --
    		 82(a)
    		 1 ↔ 1
    		 3(140302996-140304129)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC689352 hypothetical protein MGC68935 75.54(n)    BC059301.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5724761 ATP-sensitive inward rectifier potassium channel 15-like 65.64(n)
    63.27(a)    		   572476  XM_001919044.2  XP_001919079.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea irk-36
    		 Inward Rectifying K (potassium) channel family mem...
    		 28(a)
    		 possible ortholog
    		 X(14353239-14358995)


    ENSEMBL Gene Tree for KCNJ15 (if available)
    TreeFam Gene Tree for KCNJ15 (if available) 

    Paralogs
    for KCNJ15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNJ15 gene
    KCNJ42  KCNJ92  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ52  KCNJ62  
    KCNJ22  KCNJ102  KCNJ142  KCNJ32  KCNJ112  
    16 SIMAP similar genes for KCNJ15 using alignment to 9 protein entries:     IRK15_HUMAN (see all proteins):
    KCNJ1    KCNJ10    KCNJ5    KCNJ3    KCNJ6    KCNJ12
    KCNJ9    kcnj12x    KCNJ18    KCNJ2    KCNJ4    KCNJ14
    KCNJ11    KCNJ13    KCNJ8    KCNJ16

    KCNJ15 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNJ15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/954 NCBI SNPs in KCNJ15 are shown (see all 954)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1898797491,2
    		--39626671(+) CTTCCA/GTCTCC 1 -- us2k10--------
    rs1820424951,2
    		--39626867(+) CTTCCA/CTATGT 1 -- us2k10--------
    rs1402742231,2
    		--39626929(+) ATGTGC/TCAGAT 2 -- us2k10--------
    rs1433505471,2
    		--39626996(+) CACAGA/TTGGTA 2 -- us2k10--------
    rs1845912121,2
    		--39627102(+) TAAGGA/GCCTCC 2 -- us2k10--------
    rs1512943551,2
    		--39627107(+) ACCTCC/GCAGAG 2 -- us2k10--------
    rs1406492301,2
    		--39627125(+) CATTCA/GGGCTA 2 -- us2k10--------
    rs1885629901,2
    		--39627189(+) GGCCGA/CGGAAA 2 -- us2k10--------
    rs572125501,2
    		C,F,--39627209(+) CAAATC/TATCCC 2 -- us2k15Minor allele frequency- T:0.19NA WA 244
    rs1808237501,2
    		--39627222(+) CTGAGA/CAGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNJ15 (39529128 - 39673748 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for KCNJ15
         3 CNVs: 67785 7324 90773
         4 Indels: 79345 79346 59050 90774
    Human Gene Mutation Database (HGMD): KCNJ15

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    Disorders / Diseases
    for KCNJ15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNJ15 for disorders           About GeneDecksing

    OMIM gene information: 602106    OMIM disorders: --

    6 diseases for KCNJ15:    About MalaCards
    type 2 diabetes mellitus    diabetes mellitus    meniere's disease    menieres disease
    down syndrome    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: KCNJ15 (2 documents)

    Export disorders for KCNJ15 gene to outside databases

    Publications
    for KCNJ15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNJ15 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with KCNJ15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PubMed id 9299242)1, 2, 3, 9 Gosset P.... Creau N. (1997)
    2. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PubMed id 8995301)1, 2, 3 Shuck M.E....Bienkowski M.J. (1997)
    3. International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. (PubMed id 9647694)1, 2 Kurschner C.... Surmeier D.J. (1998)
    7. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. (PubMed id 11804844)1, 9 Hill C.E....Magtanong L. (2002)
    8. Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. (PubMed id 22566534)1 Okamoto K....Tokunaga K. (2012)
    9. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (PubMed id 20085713)1 Okamoto K....Tokunaga K. (2010)
    10. MUPP1 complexes renal K+ channels to alter cell surfa ce expression and whole cell currents. (PubMed id 19420109)1 Sindic A....Miller R.T. (2009)

    External Searches for KCNJ15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing KCNJ15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3772 HGNC: 6261 AceView: KCNJ15 Ensembl:ENSG00000157551 euGenes: HUgn3772
    ECgene: KCNJ15 Kegg: 3772 H-InvDB: KCNJ15

    Other Databases showing KCNJ15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNJ15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNJ15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNJ15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNJ15 gene:
    Search GeneIP for patents involving KCNJ15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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