Aliases for KCNJ15 Gene
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 15 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
- Inward Rectifier K(+) Channel Kir1.3 3 4
- Inward Rectifier K(+) Channel Kir4.2 3 4
- ATP-Sensitive Inward Rectifier Potassium Channel 15 3
External Ids for KCNJ15 Gene
Previous GeneCards Identifiers for KCNJ15 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ15 Gene
KCNJ15 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 15) is a Protein Coding gene. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.
UniProtKB/Swiss-Prot for KCNJ15 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.