Aliases for KCNJ14 Gene
Aliases for KCNJ14 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 14 2 3 5
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 14 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 14 3 4
- Inward Rectifier K(+) Channel Kir2.4 3 4
- IRK-4 3 4
- IRK4 3 4
- ATP-Sensitive Inward Rectifier Potassium Channel 14 3
- Inwardly Rectifying Potassium Channel KIR2.4 3
- KIR2.4 3
External Ids for KCNJ14 Gene
- HGNC: 6260
- Entrez Gene: 3770
- Ensembl: ENSG00000182324
- OMIM: 603953
- UniProtKB: Q9UNX9
Previous GeneCards Identifiers for KCNJ14 Gene
- GC19P049603
- GC19P049318
- GC19P053634
- GC19P053650
- GC19P048958
- GC19P045338
Summaries for KCNJ14 Gene
-
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ14 Gene
KCNJ14 (Potassium Voltage-Gated Channel Subfamily J Member 14) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Vascular smooth muscle contraction. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ2.
UniProtKB/Swiss-Prot for KCNJ14 Gene
-
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
-
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ14 Gene
Genomics for KCNJ14 Gene
Regulatory Elements for KCNJ14 Gene
Enhancers for KCNJ14 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G048424 | 1.4 | FANTOM5 Ensembl ENCODE | 12.3 | -30.4 | -30432 | 1.4 | AGO1 NFRKB ELK1 ZNF143 FOS RELB IKZF2 SMARCC1 ZBTB2 ZBTB11 | GRWD1 KCNJ14 CYTH2 TMEM143 SYNGR4 KDELR1 |
| GH19G048444 | 1.1 | ENCODE | 4.8 | -9.7 | -9735 | 2.3 | HDGF CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 | GRWD1 SNORD23 RPL18 KDELR1 ENSG00000268746 CYTH2 KCNJ14 |
| GH19G048061 | 0.4 | FANTOM5 | 13 | -394.3 | -394281 | 0.4 | MLLT1 | CABP5 KCNJ14 CRX PLA2G4C-AS1 |
| GH19G048588 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 1.9 | +133.7 | 133699 | 1.2 | HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B CBX5 ZNF416 | SULT2B1 FUT2 NTN5 SPHK2 BCAT2 CA11 KCNJ14 KDELR1 DBP MAMSTR |
| GH19G048462 | 1.1 | ENCODE | 0.4 | +7.0 | 6990 | 0.2 | HDGF CREB3L1 ARNT AGO1 SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 | BICRA GRWD1 CA11 ENSG00000268093 C19orf68 NOP53-AS1 KDELR1 SYNGR4 TMEM143 LMTK3 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around KCNJ14 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNJ14 gene promoter:
Regulatory Element Products
Genomic Location for KCNJ14 Gene
- Chromosome:
- 19
- Start:
- 48,455,509 bp from pter
- End:
- 48,466,980 bp from pter
- Size:
- 11,472 bases
- Orientation:
- Plus strand
Genomic View for KCNJ14 Gene
Genes around KCNJ14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
KCNJ14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNJ14 Gene
Proteins for KCNJ14 Gene
-
Protein details for KCNJ14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNX9-KCJ14_HUMAN
- Recommended name:
- ATP-sensitive inward rectifier potassium channel 14
- Protein Accession:
- Q9UNX9
Protein attributes for KCNJ14 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 47846 Da
- Quaternary structure:
- No Data Available
Protein Expression for KCNJ14 Gene
Post-translational modifications for KCNJ14 Gene
No Post-translational modifications
Other Protein References for KCNJ14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KCNJ14
- Invitrogen Antibodies for KCNJ14
- antibodies-online Antibodies for KCNJ14: See all 1
- Search GeneTex for Antibodies for KCNJ14
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KCNJ14
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- Novus Biologicals proteins for KCNJ14
- Search GeneTex for Proteins for KCNJ14
Assay Products
- antibodies-online Kits for KCNJ14: See all 4
No data available for DME Specific Peptides for KCNJ14 Gene
Domains & Families for KCNJ14 Gene
Gene Families for KCNJ14 Gene
- HGNC:
- IUPHAR :
Protein Domains for KCNJ14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNJ14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UNX9UniProtKB/Swiss-Prot:
KCJ14_HUMAN :- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
- Family:
-
- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
Function for KCNJ14 Gene
Molecular function for KCNJ14 Gene
- UniProtKB/Swiss-Prot Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005242 | inward rectifier potassium channel activity | IBA | -- |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
Phenotypes for KCNJ14 Gene
- GenomeRNAi human phenotypes for KCNJ14:
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNJ14
-
ViGene Biosciences lentiviral particle packaged cDNA for KCNJ14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNJ14 gene
- Search ViGene Biosciences for KCNJ14
CRISPR Products
-
OriGene CRISPR knockouts for KCNJ14
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ14
- GenScript: Design CRISPR guide RNA sequences for KCNJ14
miRNA for KCNJ14 Gene
- miRTarBase miRNAs that target KCNJ14
miRNA Products
- Search ViGene Biosciences for KCNJ14
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for KCNJ14
- Browse OriGene Inhibitory RNA Products For KCNJ14
-
ViGene Biosciences ready-to-package AAV shRNAs for KCNJ14 gene
Cell Line Products
-
Horizon Cell Lines for KCNJ14
-
ViGene Biosciences adenoviral particle packaged cDNA for KCNJ14 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNJ14 Gene
Localization for KCNJ14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNJ14 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0008076 | voltage-gated potassium channel complex | TAS | 9592090 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for KCNJ14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction | ||
| 2 | Circadian entrainment | ||
| 3 | Vascular smooth muscle contraction | ||
| 4 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
| 5 | Inwardly rectifying K+ channels | ||
Pathways by source for KCNJ14 Gene
7 Reactome pathways for KCNJ14 Gene
2 KEGG pathways for KCNJ14 Gene
1 Qiagen pathway for KCNJ14 Gene
Interacting Proteins for KCNJ14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | IEA | -- |
| GO:0010107 | potassium ion import | IBA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNJ14 Gene
Drugs & Compounds for KCNJ14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Yohimbine | Approved, Vet_approved | Pharma | Antagonist, Target | 28 | ||
| Glyburide | Approved | Pharma | Channel blocker | Kir6 (KATP) channel blocker | 114 | |
| Nicorandil | Approved | Pharma | Activator | Potassium channel activator, Kir6 (KATP) channel opener and NO donor | 17 | |
| Ba<sup>2+</sup> | Pharma | Pore Blocker | 0 | |||
| Cs<sup>+</sup> | Pharma | Antagonist, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| H<sup>+</sup> (extracellular) |
|
Activator |
|
(5) Tocris Compounds for KCNJ14 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Glibenclamide | Kir6 (KATP) channel blocker | 10238-21-8 |
| Levcromakalim | Kir6 (KATP) channel opener; active enantiomer of cromakalim (Cat. No. 1377) | 94535-50-9 |
| Nicorandil | Kir6 (KATP) channel opener and NO donor | 65141-46-0 |
| Tertiapin-Q | Selective blocker of inward-rectifier K+ channels | 252198-49-5 |
| Y-26763 | Kir6 (KATP) channel opener | 127408-31-5 |
Transcripts for KCNJ14 Gene
mRNA/cDNA for KCNJ14 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (265) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNJ14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNJ14
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ14
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for KCNJ14 gene
Flow Cytometry Products
Expression for KCNJ14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Eye (Sensory Organs)
This gene is overexpressed in Heart (51.7) and Retina (17.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ14 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KCNJ14 Gene:
KCNJ14SOURCE GeneReport for Unigene cluster for KCNJ14 Gene:
Hs.736972mRNA Expression by UniProt/SwissProt for KCNJ14 Gene:
Q9UNX9-KCJ14_HUMAN
Tissue specificity:
Expressed preferentially in retina.
Primer Products
-
OriGene qPCR primer pairs for KCNJ14
-
OriGene qPCR primer pairs and template standards for KCNJ14
No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNJ14 Gene
Orthologs for KCNJ14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KCNJ14 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | KCNJ14 34 |
|
||
| cow (Bos Taurus) |
Mammalia | KCNJ14 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Kcnj14 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kcnj14 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNJ14 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | KCNJ14 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnj14 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | kcnj14 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ir 36 |
|
|
|
| Irk3 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | irk-1 36 35 |
|
||
| irk-2 36 35 |
|
- Species where no ortholog for KCNJ14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for KCNJ14 Gene
Paralogs for KCNJ14 Gene
(16) SIMAP similar genes for KCNJ14 Gene using alignment to 1 proteins:
Variants for KCNJ14 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055611 | -- | 48,456,853(+) | TTTTT(A/G)ATTAT | intron-variant | |
| rs1000126016 | -- | 48,454,943(+) | AAACA(-/TTTCT)TTTCT | upstream-variant-2KB | |
| rs1000128892 | -- | 48,458,300(+) | ATTCC(A/C/T)CACAG | intron-variant | |
| rs1000178712 | -- | 48,455,144(+) | GATCA(A/G)TGTCC | upstream-variant-2KB | |
| rs1000430115 | -- | 48,457,139(+) | ACCAT(C/G)GCTGG | intron-variant |
Residual Variation Intolerance Score:
50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.23;
40.14% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNJ14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KCNJ14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ14 Gene
Disorders for KCNJ14 Gene
Relevant External Links for KCNJ14
No disorders were found for KCNJ14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNJ14 Gene
Publications for KCNJ14 Gene
- Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). (PMID: 10723734) Toepert C. … Karschin A. (Mamm. Genome 2000) 2 3 4 22 64
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
- International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3 64
- Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PMID: 15958527) Fang Y. … Levitan I. (Am. J. Physiol., Cell Physiol. 2005) 3 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for KCNJ14 Gene
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- VectorBuilder custom plasmid, inducible vectors for KCNJ14
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for KCNJ14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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