Aliases for KCNJ14 Gene
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 14 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 14 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 14 3 4
- Inward Rectifier K(+) Channel Kir2.4 3 4
- IRK-4 3 4
- IRK4 3 4
- ATP-Sensitive Inward Rectifier Potassium Channel 14 3
- Inwardly Rectifying Potassium Channel KIR2.4 3
- KIR2.4 3
External Ids for KCNJ14 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ14 Gene
KCNJ14 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 14) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.
UniProtKB/Swiss-Prot for KCNJ14 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.