KCNJ14 Gene

Aliases
for KCNJ14 gene

Previous GC identifers: GC19P049603 GC19P049318 GC19P053634 GC19P053650 GC19P045338

Summaries
for KCNJ14 gene

Genomic Views
for KCNJ14 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: KCNJ14 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ14

KCNJ14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048958:  view genomic region     (about GC identifiers)

Proteins
for KCNJ14 gene

Explore the universe of human proteins at neXtProt for KCNJ14: NX_Q9UNX9

KCNJ14 Protein expression data from MOPED and PaxDb:    About this image 

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	Uscn Proteins for KCNJ14

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

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	Uscn Antibodies for KCNJ14
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	Uscn ELISAs and CLIAs for KCNJ14

Protein Domains /
Families
for KCNJ14 gene

ProtoNet protein and cluster: Q9UNX9

Function
for KCNJ14 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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		hsa-miR-146b-3p hsa-miR-4254 hsa-miR-1271 hsa-miR-4299 hsa-miR-520a-5p hsa-miR-9 hsa-miR-96 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: KCNJ14 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KCNJ14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ14 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ14 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ14

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for KCNJ14 gene

	Super-pathway	contained gene-specific pathways
1	Potassium Channels	Potassium Channels 1.00
2	Classical Kir channels	Classical Kir channels 1.00
3	Potassium transporters: inward current	Potassium transporters: inward current 1.00
4	Dopamine-DARPP32 Feedback onto cAMP Pathway	Dopamine-DARPP32 Feedback onto cAMP Pathway 1.00
5	Inwardly rectifying K+ channels	Inwardly rectifying K+ channels 1.00

1 EMD Millipore Pathway for KCNJ14

Potassium transporters- inward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ14

Dopamine-DARPP32 Feedback onto cAMP Pathway

4        Reactome Pathways for KCNJ14

	Potassium Channels
	Classical Kir channels
	Neuronal System
	Inwardly rectifying K+ channels

1         Kegg Pathway  (Kegg details for KCNJ14)

Cholinergic synapse

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for KCNJ14 gene

Transcripts
for KCNJ14 gene

Expression
for KCNJ14 gene

KCNJ14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGGAGTC

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor Cells			Motor Neurons
	Neural TubeTelencephalon			Neural Tube
	Spinal CordSpinal Ventral Columns			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ14

Orthologs
for KCNJ14 gene

Paralogs
for KCNJ14 gene

Paralogs for KCNJ14 gene

KCNJ4²  KCNJ9²  KCNJ16²  KCNJ8²  KCNJ1²  KCNJ15²  KCNJ12²  KCNJ5²  

KCNJ6²  KCNJ2²  KCNJ10²  KCNJ3²  KCNJ11²  

16 SIMAP similar genes for KCNJ14 using alignment to 1 protein entry:     IRK14_HUMAN:

KCNJ2    KCNJ12    KCNJ18    kcnj12x    KCNJ4    KCNJ5

KCNJ9    KCNJ11    KCNJ1    KCNJ3    KCNJ15    KCNJ16

KCNJ6    KCNJ8    KCNJ10    KCNJ13

KCNJ14 for paralogs           About GeneDecksing

Genomic Variants
for KCNJ14 gene

10/256 NCBI SNPs in KCNJ14 are shown (see all 256)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1811023061,2		--	48956769(+)	TTTGTA/GTTTTT	2	--	ut31 us2k1		0	--	--	--	--
rs1449455311,2		--	48956880(+)	CAGGCA/GTGAGC	2	--	us2k1 ut31		0	--	--	--	--
rs1178468221,2	F,	--	48956951(+)	TATACA/TGTGGC	2	--	ut31 us2k1		1		EA	120
rs568088671,2	C,	--	48956986(+)	CCTCCA/CACACA	2	--	ut31 us2k1		2		WA	120
rs1490703221,2		--	48957327(+)	CCGCCA/GCGTTC	2	--	ds5001 us2k1		0	--	--	--	--
rs1441615511,2		--	48957394(+)	TCATCC/TCTGAC	2	--	ds5001 us2k1		0	--	--	--	--
rs37607981,2	C,F,A,H,	--	48957497(+)	TTCTCT/CGTGTC	2	--	ds5001 us2k1 trp3		20		EA NS NA WA CSA	3625
rs1866458151,2		--	48957529(+)	TCCCCC/GACTGC	2	--	ds5001 us2k1		0	--	--	--	--
rs1477731331,2		--	48957555(+)	CTAGTC/TGCTGT	2	--	us2k1 ds5001		0	--	--	--	--
rs17992721,2	C,F,A,	--	48957577(-)	GAGACG/AGCGGC	2	--	us2k1 ds5001		7		NA WA EA	366

HapMap Linkage Disequilibrium report for KCNJ14 (48958766 - 48969367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNJ14
     1 CNV: 32261

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ14

DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ14

Disorders / Diseases
for KCNJ14 gene

Publications
for KCNJ14 gene

PubMed articles for KCNJ14 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with KCNJ14)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). (PubMed id 10723734)^{1, 2, 3, 9} Toepert C.... Karschin A. (2000)
2. International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{1, 3} Kubo Y....Vandenberg C.A. (2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Cloning and functional expression of human retinal Kir2.4, a pH- sensitive inwardly rectifying K+ channel. (PubMed id 10942728)^{1, 2} Hughes B.A.... Swaroop A. (2000)
5. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. (PubMed id 9592090)^{1, 3} Topert C....Karschin A. (1998)
6. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PubMed id 15958527)^{1, 9} Fang Y....Levitan I. (2005)
7. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)¹ Yokoyama K....Hosoya T. (2010)
8. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)¹ Ji W....Lifton R.P. (2008)
9. Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. (PubMed id 17347781)¹ Tennant B.P....Clapp L.H. (2006)
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

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