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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNJ14 Gene

protein-coding   GIFtS: 55
GCID: GC19P048958

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 141 2     IRK42 3
Inward Rectifier K(+) Channel Kir2.42 3     KIR2.42
Potassium Channel, Inwardly Rectifying Subfamily J Member 142 3     ATP-Sensitive Inward Rectifier Potassium Channel 142
IRK-42 3     Inwardly Rectifying Potassium Channel KIR2.42

External Ids:    HGNC: 62601   Entrez Gene: 37702   Ensembl: ENSG000001823247   OMIM: 6039535   UniProtKB: Q9UNX93   

Export aliases for KCNJ14 gene to outside databases

Previous GC identifers: GC19P049603 GC19P049318 GC19P053634 GC19P053650 GC19P045338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNJ14 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel, and probably has a role in controlling the excitability of motor neurons. (provided by RefSeq, Feb 2013)

GeneCards Summary for KCNJ14 Gene: 
KCNJ14 (potassium inwardly-rectifying channel, subfamily J, member 14) is a protein-coding gene. Diseases associated with KCNJ14 include meniere's disease, and menieres disease, and among its related super-pathways are Activation of G protein gated Potassium channels and Transmission across Chemical Synapses. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular
potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14
gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By
similarity)

summary for KCNJ14 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNJ14 gene promoter:
         Egr-2   Pax-2   Pax-2a   Ik-3   ITF-2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ14 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNJ14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13

KCNJ14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048958:  view genomic region     (about GC identifiers)

Start:
48,958,766 bp from pter      End:
48,969,367 bp from pter
Size:
10,602 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9 (See protein sequence)
Recommended Name: ATP-sensitive inward rectifier potassium channel 14  
Size: 436 amino acids; 47846 Da
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNJ14: NX_Q9UNX9

Explore proteomics data for KCNJ14 at MOPED 

KCNJ14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KCNJ14 Protein Expression

REFSEQ proteins: NP_037480.1  
ENSEMBL proteins: 
 ENSP00000341479   ENSP00000375756  
Reactome Protein details: Q9UNX9
Human Recombinant Protein Products for KCNJ14: 
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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0008076voltage-gated potassium channel complex TAS9592090
GO:0016021integral to membrane ----
GO:0030425dendrite IEA--
GO:0043025neuronal cell body IEA--

KCNJ14 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KCN: Potassium channels
KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

IUPHAR Guide to PHARMACOLOGY protein family classification: Kir2.4 
Inwardly rectifying potassium channels

3 InterPro protein domains:
 IPR014756 Ig_E-set
 IPR013518 K_chnl_inward-rec_Kir_cyto
 IPR016449 K_chnl_inward-rec_Kir

Graphical View of Domain Structure for InterPro Entry Q9UNX9

ProtoNet protein and cluster: Q9UNX9

1 Blocks protein domain: IPB001838 Inward rectifier K+ channel superfamily signature

UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9
Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily


KCNJ14 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IRK14_HUMAN, Q9UNX9
Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular
potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14
gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By
similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005242inward rectifier potassium channel activity IEA--
     
KCNJ14 for ontologies           About GeneDecksing


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Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KCNJ14 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Inwardly rectifying K+ channels
Inwardly rectifying K+ channels0.81
2Transmission across Chemical Synapses
Neuronal System0.67
3Potassium Channels
Potassium Channels0.43
4Circadian entrainment
Cholinergic synapse0.37
5Potassium transporters: inward current
Potassium transporters: inward current

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for KCNJ14
    Potassium transporters- inward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ14
    Dopamine-DARPP32 Feedback onto cAMP Pathway

4        Reactome Pathways for KCNJ14
    Potassium Channels
Classical Kir channels
Neuronal System
Inwardly rectifying K+ channels


1         Kegg Pathway  (Kegg details for KCNJ14):
    Cholinergic synapse


KCNJ14 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNJ14

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for KCNJ14 (ENSP000003414794) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KCNJ12ENSP000003281504STRING: ENSP00000328150
KCNJ2ENSP000002434574STRING: ENSP00000243457
KCNJ4ENSP000003064974STRING: ENSP00000306497
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006813potassium ion transport ----
GO:0007268synaptic transmission TAS--

KCNJ14 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNJ14 available from Tocris Bioscience    About this table
CompoundAction CAS #
LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
P1075Potent Kir6 (KATP) channel opener[60559-98-0]
Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

1 HMDB Compound for KCNJ14    About this table
CompoundSynonyms CAS #PubMed Ids
MagnesiumMagnesium (see all 2)7439-95-4--

4 IUPHAR Ligands for KCNJ14 (Kir2.4)    About this table 
LigandTypeActionAffinityPubmed IDs
H+ (extracellular)
Gating inhibitorAntagonist7.1410942728
Cs+
Pore BlockerAntagonist3 - 4.0810942728
Ba2+
Pore BlockerAntagonist3.3210942728
Mg2+
InhibitorNone3.32--

Search CenterWatch for drugs/clinical trials and news about KCNJ14 / IRK14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNJ14 gene (2 alternative transcripts): 
NM_013348.3  NM_170720.1  

Unigene Clusters for KCNJ14:

Potassium inwardly-rectifying channel, subfamily J, member 14
Hs.736972  [show with all ESTs], Hs.745133  [show with all ESTs]
Unigene Representative Sequences: BM546674, AF081466
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000342291(uc002pje.1) ENST00000391884(uc002pjf.1)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidKCNJ14 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ14

Additional mRNA sequence: 

AF081466.1 BC035918.1 

7 DOTS entries:

DT.100019103  DT.426097  DT.91651388  DT.100845723  DT.121429597  DT.308230  DT.95112227 

24/265 AceView cDNA sequences (see all 265):

BQ642325 BQ642077 CR598477 CR616744 CK904655 CR608279 NM_013348 AI990076 
BM467438 CB109265 BM695721 BU859069 CR617009 AA349001 BM423457 BQ066703 
AA678452 CA454439 BM834291 BQ640151 BX416164 CR607678 BX343873 CB142128 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNJ14 expression in normal human tissues (normalized intensities)      KCNJ14 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAGGAGTC
KCNJ14 Expression
About this image


KCNJ14 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Pons
         brain/forebrain/telencephalon   
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Telencephalon
 
 Smooth Muscle (Muscoskeletal System)
         Juxtaglomerular Cells Afferent Arteriole
 
 Kidney (Urinary System)
         Juxtaglomerular Cells Afferent Arteriole
 
 Spinal Cord (Nervous System)
         Ventral Horn   

See KCNJ14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ14

SOURCE GeneReport for Unigene clusters: Hs.736972 Hs.745133

UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9
Tissue specificity: Expressed preferentially in retina

    SABiosciences Expression via Pathway-Focused PCR Array including KCNJ14: 
          Neuronal Ion Channels in human mouse rat

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCNJ14 gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcnj141 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 88.25(n)1
94.7(a)1
  7 (29.53 cM)5
2114801  NM_145963.21  NP_666075.11 
 458164675 
lizard
(Anolis carolinensis)
Reptilia KCNJ146
Uncharacterized protein
66(a)
1 ↔ 1
GL343329.1(775403-809460)
zebrafish
(Danio rerio)
Actinopterygii kcnj141 potassium inwardly-rectifying channel, subfamily J, more 64.27(n)
65.96(a)
  100526806  XM_003200166.1  XP_003200214.1 


ENSEMBL Gene Tree for KCNJ14 (if available)
TreeFam Gene Tree for KCNJ14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KCNJ14 gene
KCNJ42  KCNJ92  KCNJ162  KCNJ82  KCNJ12  KCNJ122  KCNJ152  KCNJ52  
KCNJ62  KCNJ22  KCNJ102  KCNJ32  KCNJ112  
16 SIMAP similar genes for KCNJ14 using alignment to 1 protein entry:     IRK14_HUMAN:
KCNJ2    KCNJ12    KCNJ18    kcnj12x    KCNJ4    KCNJ5
KCNJ9    KCNJ11    KCNJ1    KCNJ3    KCNJ15    KCNJ16
KCNJ6    KCNJ8    KCNJ10    KCNJ13

KCNJ14 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/294 SNPs in KCNJ14 are shown (see all 294)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs104058071,2
C,A--48957700(+) GATCCA/CTCTGT 1 -- us2k1 tfbs30--------
rs621302711,2
F--48957713(+) ACTCCG/AAGGTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1886000801,2
--48957740(+) GCCCCA/TGGGAC 1 -- us2k10--------
rs1910350011,2
--48957852(+) ACGTGA/CCTCCA 1 -- us2k10--------
rs1835407441,2
--48957906(+) CCCCCA/CTCCAC 1 -- us2k10--------
rs776962051,2
F--48957931(+) CCCTGT/CCCTCA 1 -- us2k11Minor allele frequency- C:0.01WA 118
rs1874685071,2
--48958000(+) AATCCA/GCCCCC 1 -- us2k10--------
rs1922759931,2
--48958005(+) ACCCCC/TAGGTT 1 -- us2k10--------
rs1480688251,2
--48958007(+) CCCCAA/GGTTCA 1 -- us2k10--------
rs739422841,2
C--48958075(+) TTTCAG/AAGAAA 1 -- us2k15Minor allele frequency- A:0.08WA CSA NA EA 361

HapMap Linkage Disequilibrium report for KCNJ14 (48958766 - 48969367 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for KCNJ14:    About this table     
Variant IDTypeSubtypePubMed ID
nsv828572CNV Loss20364138
nsv912222CNV Loss21882294
nsv912223CNV Loss21882294
nsv912221CNV Loss21882294
nsv912219CNV Loss21882294
nsv9739CNV Gain+Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603953    OMIM disorders: --

6 diseases for KCNJ14:    About MalaCards
meniere's disease    menieres disease    hyperparathyroidism    retinitis
neuronitis    endotheliitis

1 disease from the University of Copenhagen DISEASES database for KCNJ14:
Meniere's disease

KCNJ14 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNJ14
Human Genome Epidemiology (HuGE) Navigator: KCNJ14 (1 document)

Export disorders for KCNJ14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KCNJ14 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KCNJ14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). (PubMed id 10723734)1, 2, 3, 9 Toepert C.... Karschin A. (2000)
  2. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
  3. International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Cloning and functional expression of human retinal Kir2.4, a pH- sensitive inwardly rectifying K+ channel. (PubMed id 10942728)1, 2 Hughes B.A.... Swaroop A. (2000)
  6. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. (PubMed id 9592090)1, 3 Topert C....Karschin A. (1998)
  7. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PubMed id 15958527)1, 9 Fang Y....Levitan I. (2005)
  8. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)1 Ji W....Lifton R.P. (2008)
  9. Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. (PubMed id 17347781)1 Tennant B.P....Clapp L.H. (2006)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3770 HGNC: 6260 AceView: PSCD2andKCNJ14andGRWD1 Ensembl:ENSG00000182324 euGenes: HUgn3770
ECgene: KCNJ14 Kegg: 3770 H-InvDB: KCNJ14

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KCNJ14 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNJ14 gene:
Search GeneIP for patents involving KCNJ14

GeneCards and IP:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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