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Aliases for KCNJ14 Gene

Aliases for KCNJ14 Gene

  • Potassium Voltage-Gated Channel Subfamily J Member 14 2 3
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 14 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J, Member 14 3 5
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 14 3 4
  • Inward Rectifier K(+) Channel Kir2.4 3 4
  • IRK-4 3 4
  • IRK4 3 4
  • Inwardly Rectifying Potassium Channel KIR2.4 3
  • KIR2.4 3

External Ids for KCNJ14 Gene

Previous GeneCards Identifiers for KCNJ14 Gene

  • GC19P049603
  • GC19P049318
  • GC19P053634
  • GC19P053650
  • GC19P048958
  • GC19P045338

Summaries for KCNJ14 Gene

Entrez Gene Summary for KCNJ14 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

GeneCards Summary for KCNJ14 Gene

KCNJ14 (Potassium Voltage-Gated Channel Subfamily J Member 14) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Inwardly rectifying K+ channels. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.

UniProtKB/Swiss-Prot for KCNJ14 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).

Tocris Summary for KCNJ14 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Gene Wiki entry for KCNJ14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ14 Gene

Genomics for KCNJ14 Gene

Regulatory Elements for KCNJ14 Gene

Genomic Location for KCNJ14 Gene

Chromosome:
19
Start:
48,455,509 bp from pter
End:
48,466,980 bp from pter
Size:
11,472 bases
Orientation:
Plus strand

Genomic View for KCNJ14 Gene

Genes around KCNJ14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNJ14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNJ14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ14 Gene

Proteins for KCNJ14 Gene

  • Protein details for KCNJ14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNX9-KCJ14_HUMAN
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 14
    Protein Accession:
    Q9UNX9

    Protein attributes for KCNJ14 Gene

    Size:
    436 amino acids
    Molecular mass:
    47846 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCNJ14 Gene

Proteomics data for KCNJ14 Gene at MOPED

Post-translational modifications for KCNJ14 Gene

No Post-translational modifications

Other Protein References for KCNJ14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNJ14 Gene

Domains & Families for KCNJ14 Gene

Gene Families for KCNJ14 Gene

Suggested Antigen Peptide Sequences for KCNJ14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNX9

UniProtKB/Swiss-Prot:

KCJ14_HUMAN :
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.
genes like me logo Genes that share domains with KCNJ14: view

Function for KCNJ14 Gene

Molecular function for KCNJ14 Gene

UniProtKB/Swiss-Prot Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).

Phenotypes for KCNJ14 Gene

genes like me logo Genes that share phenotypes with KCNJ14: view

Animal Model Products

miRNA for KCNJ14 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNJ14 Gene

Localization for KCNJ14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNJ14 Gene COMPARTMENTS Subcellular localization image for KCNJ14 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for KCNJ14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex TAS 9592090
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with KCNJ14: view

Pathways & Interactions for KCNJ14 Gene

genes like me logo Genes that share pathways with KCNJ14: view

Pathways by source for KCNJ14 Gene

Interacting Proteins for KCNJ14 Gene

Gene Ontology (GO) - Biological Process for KCNJ14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA --
GO:0061337 cardiac conduction TAS --
genes like me logo Genes that share ontologies with KCNJ14: view

No data available for SIGNOR curated interactions for KCNJ14 Gene

Drugs & Compounds for KCNJ14 Gene

(9) Drugs for KCNJ14 Gene - From: HMDB, DGIdb, IUPHAR, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved Pharma Antagonist, Target 25
Diazoxide Approved Pharma Activator Blocks desensitization of AMPA receptors 21
Minoxidil Approved Pharma Activator Kir6 channel (KATP) opener 33
Ba<sup>2+</sup> Pharma Pore Blocker 0
Cs<sup>+</sup> Pharma Antagonist, Pore Blocker 0

(3) Additional Compounds for KCNJ14 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
H<sup>+</sup> (extracellular)
Activator
P1075
60559-98-0
ZM 226600
147695-92-9
genes like me logo Genes that share compounds with KCNJ14: view

Transcripts for KCNJ14 Gene

mRNA/cDNA for KCNJ14 Gene

Unigene Clusters for KCNJ14 Gene

Potassium inwardly-rectifying channel, subfamily J, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ14 Gene

No ASD Table

Relevant External Links for KCNJ14 Gene

GeneLoc Exon Structure for
KCNJ14
ECgene alternative splicing isoforms for
KCNJ14

Expression for KCNJ14 Gene

mRNA expression in normal human tissues for KCNJ14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNJ14 Gene

This gene is overexpressed in Heart (51.7) and Retina (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ14 Gene



SOURCE GeneReport for Unigene cluster for KCNJ14 Gene Hs.736972

mRNA Expression by UniProt/SwissProt for KCNJ14 Gene

Q9UNX9-KCJ14_HUMAN
Tissue specificity: Expressed preferentially in retina.
genes like me logo Genes that share expression patterns with KCNJ14: view

Protein tissue co-expression partners for KCNJ14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KCNJ14 Gene

Orthologs for KCNJ14 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ14 35
  • 99.62 (n)
  • 99.77 (a)
KCNJ14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNJ14 36
  • 95 (a)
OneToOne
KCNJ14 35
  • 91.17 (n)
  • 94.7 (a)
dog
(Canis familiaris)
Mammalia KCNJ14 35
  • 92.59 (n)
  • 95.6 (a)
mouse
(Mus musculus)
Mammalia Kcnj14 16
Kcnj14 36
  • 94 (a)
OneToOne
Kcnj14 35
  • 88.25 (n)
  • 94.7 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ14 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnj14 35
  • 87.71 (n)
  • 94.47 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia KCNJ14 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj14 35
  • 64.66 (n)
  • 71.8 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnj14 35
  • 66.1 (n)
  • 69.01 (a)
kcnj14 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ir 37
  • 49 (a)
Irk3 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea irk-1 36
  • 32 (a)
ManyToMany
irk-2 36
  • 37 (a)
ManyToMany
irk-1 37
  • 49 (a)
irk-2 37
  • 47 (a)
Species with no ortholog for KCNJ14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNJ14 Gene

ENSEMBL:
Gene Tree for KCNJ14 (if available)
TreeFam:
Gene Tree for KCNJ14 (if available)

Paralogs for KCNJ14 Gene

(16) SIMAP similar genes for KCNJ14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNJ14: view

Variants for KCNJ14 Gene

Sequence variations from dbSNP and Humsavar for KCNJ14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745725 - 48,464,331(+) TAGGA(C/T)GTGCC reference, missense
rs1799271 -- 48,461,730(-) GCCAG(C/G)CCCAT reference, synonymous-codon
rs8104067 -- 48,458,105(+) tggtt(A/G)atact intron-variant
rs7257118 -- 48,456,385(+) TGTCA(A/G)GGGTG intron-variant
rs10410041 -- 48,459,672(+) ataca(A/G)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ14 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912219 CNV Loss 21882294
nsv828572 CNV Loss 20364138
nsv912221 CNV Loss 21882294
nsv912222 CNV Loss 21882294
nsv912223 CNV Loss 21882294

Variation tolerance for KCNJ14 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNJ14 Gene

HapMap Linkage Disequilibrium report
KCNJ14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ14 Gene

Disorders for KCNJ14 Gene

Relevant External Links for KCNJ14

Genetic Association Database (GAD)
KCNJ14
Human Genome Epidemiology (HuGE) Navigator
KCNJ14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNJ14

No disorders were found for KCNJ14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNJ14 Gene

Publications for KCNJ14 Gene

  1. Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). (PMID: 10723734) Toepert C. … Karschin A. (Mamm. Genome 2000) 2 3 4 23 67
  2. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3
  3. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PMID: 15958527) Fang Y. … Levitan I. (Am. J. Physiol., Cell Physiol. 2005) 3 23
  4. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. (PMID: 9592090) TAPpert C. … Karschin A. (J. Neurosci. 1998) 2 3
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3

Products for KCNJ14 Gene

Sources for KCNJ14 Gene

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