KCNJ12 Gene
protein-coding GIFtS: 62
GCID: GC17P021339
|
|
potassium inwardly-rectifying channel, subfamily J, member...(Previous names: potassium inwardly-rectifying channel, subfamily J, inhibitor...)
(Previous symbol: KCNJN1)
| |
Aliases
for KCNJ12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Inwardly-Rectifying Channel, Subfamily J, Member 121 2 | | Inward Rectifier K(+) Channel Kir2.2v2 3 | | KCNJN11 2 3 5 | | Potassium Channel, Inwardly Rectifying Subfamily J Member 122 3 | | IRK21 2 3 | | IRK-22 3 | | Kir2.21 2 | | ATP-Sensitive Inward Rectifier Potassium Channel 122 | | Kir2.2v1 2 | | HIRK1 | | HIRK11 | | Hkir2.2x1 | | Potassium Inwardly-Rectifying Channel, Subfamily J, Inhibitor 11 2 | | Inward Rectifier K(+) Channel Kir2.62 | | Inward Rectifier K(+) Channel Kir2.22 3 | | Kcnj12x1 |
Export aliases for KCNJ12 gene to outside databasesPrevious GC identifers: GC17P021500 GC17P022929 GC17P021184 GC17P021441 GC17P021220 GC17P021259 GC17P020482 |
Summaries
for KCNJ12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNJ12:
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thoughtto be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). Thegene is located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IRK12_HUMAN, Q14500Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscletissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellularbarium and cesium
 summary
for KCNJ12: The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.
Gene Wiki entry for KCNJ12
|
Genomic Views
for KCNJ12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNJ12 gene promoter:
AhR AML1a Pax-6 HNF-4alpha1 Arnt N-Myc FOXO1a ZID FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNJ12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.1KCNJ12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P021339: view genomic region
(about GC identifiers)
Start:
|
21,279,509 bp from pter |
End:
|
21,323,179 bp from pter |
Size:
|
43,671 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+,PATCHES 21,280,389-21,323,869 |
|
Proteins
for KCNJ12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IRK12_HUMAN, Q14500 (See
protein sequence)Recommended Name: ATP-sensitive inward rectifier potassium channel 12 Size: 433 amino acids; 49001 Da
Subunit: Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key rolein its localization and trafficking (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43401 Q15756 Q8NG63Explore the universe of human proteins at neXtProt for KCNJ12: NX_Q14500
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14500
KCNJ12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066292.2
ENSEMBL proteins: ENSP00000463778 ENSP00000328150 Reactome Protein details: Q14500
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
KCNJ12 for ontologies About GeneDecksing
KCNJ12 Antibody Products:
Assay Products for KCNJ12: |
Protein
Domains /
Families
for KCNJ12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNJ12 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14500ProtoNet protein and cluster: Q14500 3 Blocks protein families: IPB001838 Inward rectifier K+ channel superfamily signature IPB003272 Kir2.2 inward rectifier K+ channel signature IPB013673 Inward rectifier potassium channel N-terminal
UniProtKB/Swiss-Prot: IRK12_HUMAN, Q14500Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily |
Function
for KCNJ12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IRK12_HUMAN, Q14500Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscletissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellularbarium and cesium Genatlas biochemistry entry for KCNJ12:potassium non voltage-gated channel,inwardly rectifying,subfamily J,alpha subunit KIR2.2,unlikely to be involved in theSmith-Magenis syndrome
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KCNJ12 (NM_021012) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNJ12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ12 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
KCNJ12 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for KCNJ12:
Animal Models:
Mouse knock-out Kcnj12tm1Swz for KCNJ12
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kcnj12):
KCNJ12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNJ12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Inwardly rectifying K+ channels | | | 2 | Activation of GABAB receptors | | | 3 | Transmission across Chemical Synapses | | | 4 | Potassium Channels | | | 5 | Classical Kir channels | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for KCNJ12
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNJ12
5/12 
Reactome Pathways for KCNJ12 (see all 12)
1 
Kegg Pathway (Kegg details for KCNJ12):
KCNJ12 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNJ12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/20 Interacting proteins for KCNJ12 (Q145003 ENSP000003281504) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
KCNJ12 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNJ12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
KCNJ12 for compounds About GeneDecksing
Compounds for KCNJ12 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Tertiapin-Q | Selective blocker of inward-rectifier K+ channels | [252198-49-5] |
1 HMDB Compound for KCNJ12 About this table
1 DrugBank Compound for KCNJ12 About this table
1 Novoseek chemical compound relationship for KCNJ12 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| potassium |
55.2 |
5 |
12417321 (2), 9533018 (1), 15276477 (1) |
Search CenterWatch for drugs/clinical trials and news about KCNJ12 / IRK12
|
Transcripts
for KCNJ12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNJ12 gene: NM_021012.4 Unigene Cluster for KCNJ12: Potassium inwardly-rectifying channel, subfamily J, member 12 Hs.200629 [show with all ESTs]Unigene Representative Sequence: NM_0210122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583088(uc002gyv.1 uc021tss.1) ENST00000331718
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCNJ12 (NM_021012) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNJ12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ12 |
Additional cDNA sequence: AB182123.1 AF005214.1 AK024229.1 BC027982.1 FJ434338.2 L36069.1 2 DOTS entries: DT.303212 DT.100750085 20 AceView cDNA sequences: AW299543 CD673578 AB182123 BX279845 BE550570 NM_021012 BM692647 AW299888 BC027982 AF005214 BE552277 BV189339 AI916525 BE783053 L36069 F29406 BX387181 AW297073 BX345071 BG332575
GeneLoc Exon Structure
|
Expression
for KCNJ12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNJ12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATTTTCAA
About this image
See KCNJ12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNJ12
SOURCE GeneReport for Unigene cluster: Hs.200629
SABiosciences Expression via Pathway-Focused PCR Arrays including KCNJ12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNJ12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNJ12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNJ12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ12 |
Orthologs
for KCNJ12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNJ12 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KCNJ121 |
potassium inwardly-rectifying channel, subfamily J, more |
76.21(n)
87.09(a) |
|
427662 XM_425235.2 XP_425235.2 |
lizard
(Anolis carolinensis) |
Reptilia |
KCNJ126 |
-- |
81(a) |
1 ↔ 1 |
GL343385.1(938933-940252) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5691461 |
ATP-sensitive inward rectifier potassium channel 12-like |
74.42(n)
79.53(a) |
|
569146 XM_692512.2 XP_697604.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ir3 |
inward rectifier potassium channel |
52(a)
(best of 3) |
|
94E4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
irk-23 |
potassium channel |
49(a)
(best of 2) |
|
X(739153-745460) -- |
ENSEMBL Gene Tree for KCNJ12 (if available)
TreeFam Gene Tree for KCNJ12 (if available) |
Paralogs
for KCNJ12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNJ12 gene
- KCNJ42 KCNJ92 KCNJ162 KCNJ82 KCNJ12 KCNJ152 KCNJ52 KCNJ62
- KCNJ22 KCNJ102 KCNJ142 KCNJ32 KCNJ112
16 SIMAP similar genes for KCNJ12 using alignment to 1 protein entry: IRK12_HUMAN:KCNJ18 kcnj12x KCNJ2 KCNJ4 KCNJ5 KCNJ14
KCNJ11 KCNJ6 KCNJ9 KCNJ3 KCNJ8 KCNJ15
KCNJ1 KCNJ16 KCNJ10 KCNJ13
KCNJ12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KCNJ12
PGOHUM00000237325
|
Genomic Variants
for KCNJ12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNJ12 (21279509 - 21323179 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KCNJ12
8 CNVs: 5857 43944 102428 61563 7149 53641 4027 8837 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ12 |
|
Disorders
/ Diseases
for KCNJ12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNJ12 for disorders About GeneDecksing
OMIM gene information: 602323
OMIM disorders: --
8  diseases for KCNJ12: About MalaCardssmith-magenis syndrome lens subluxation hyperinsulinemic hypoglycemia poliomyelitis
hyperinsulinism hypoglycemia cholesterol neuronitis
4 diseases from the University of Copenhagen DISEASES database for KCNJ12:Hypokalemic periodic paralysis Lens subluxation Hyperinsulinemic hypoglycemia Bartter disease Export disorders for KCNJ12 gene to outside databases
|
Publications
for KCNJ12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNJ12 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with KCNJ12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes. (PubMed id 12417321)1, 2, 3, 9 Kaibara M....Taniyama K. (2002)
- Cloning and functional expression of an inwardly rectifying K+ channel from human atrium. (PubMed id 7859381)1, 2, 3 Wible B.A.... Brown A.M. (1995)
- International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An alternate promoter directs expression of a truncated, muscle- specific isoform of the human ankyrin 1 gene. (PubMed id 9430667)1, 2 Gallagher P.G. and Forget B.G. (1998)
- Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2. (PubMed id 8647284)1, 2 Namba N.... Seino S. (1996)
- Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PubMed id 15958527)1, 9 Fang Y....Levitan I. (2005)
- The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1. (PubMed id 9533018)1, 9 Namba N....Seino Y. (1997)
- Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1. (PubMed id 16258766)1, 9 Kiesecker C....Karle C.A. (2006)
- Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery. (PubMed id 12598232)1, 9 Karkanis T....Sims S.M. (2003)
|
External Searches for KCNJ12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNJ12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNJ12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNJ12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCNJ12 gene:
Search GeneIP for patents involving KCNJ12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNJ12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KCNJ12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNJ12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNJ12 | | | OriGene Protein Over-expression Lysate for KCNJ12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KCNJ12 | | OriGene 3'-UTR Clone for KCNJ12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNJ12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KCNJ12 | | OriGene Custom Protein Services for KCNJ12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNJ12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNJ12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNJ12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNJ12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNJ12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNJ12 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | KCNJ12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ12 |
|  |  |  | | | | Search ThermoFisher Antibodies for KCNJ12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ12 |
|
|
|
|
