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KCNJ10 Gene

protein-coding GIFtS: 65

GC01M158273

potassium inwardly-rectifying channel, subfamily J, member 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BIRK-10 ^²
KCNJ13-PEN ^²
KIR1.2 ^²
KIR4.1 ^²
Kir1.2 ^¹
Kir4.1 ^¹
OTTHUMP00000025748 ^²
SESAME ^², ⁵

Descriptions
ATP-dependent inwardly rectifying potassium channel Kir4.1 ^³
ATP-sensitive inward rectifier potassium channel 10 ^²
Inward rectifier K(+) channel Kir1.2 ^³
Potassium channel, inwardly rectifying subfamily J member 10 ^³
glial ATP-dependent inwardly rectifying potassium channel KIR4.1 ^²
inward rectifier K+ channel KIR1.2 ^²
inwardly-rectifying potassium channel Kir1.2 ^²
potassium inwardly-rectifying channel, subfamily J, member 10 ^²

External Ids
HGNC: 6256¹
Entrez Gene: 3766²
UniProtKB: P78508³
Ensembl: ENSG00000177807⁷

Search outside databases for aliases for KCNJ10 gene

Previous GC identifers: GC01M157802 GC01M155740 GC01M156785 GC01M157224 GC01M156821

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNJ10:

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by

having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded

protein may form a heterodimer with another potassium channel protein and may be responsible for

the potassium buffering action of glial cells in the brain. Mutations in this gene have been

associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.

[provided by RefSeq]

UniProtKB/Swiss-Prot: IRK10_HUMAN, P78508

Function: May be responsible for potassium buffering action of glial cells in the brain. Inward

rectifier potassium channels are characterized by a greater tendency to allow potassium to flow

into the cell rather than out of it. Their voltage dependence is regulated by the concentration of

extracellular potassium; as external potassium is raised, the voltage range of the channel opening

shifts to more positive voltages. The inward rectification is mainly due to the blockage of

outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By

similarity)

Gene Wiki entry for KCNJ10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNJ10 gene

Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23.2

KCNJ10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M158273: (about GC identifiers)

Start:	158,274,657 bp from pter
End:	158,306,585 bp from pter
Size:	31,929 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IRK10_HUMAN, P78508 (See protein sequence)

Recommended Name: ATP-sensitive inward rectifier potassium channel 10

Size: 379 amino acids; 42508 Da

Subunit: Seems to form heterodimer with Kir5.1/KCNJ16. Interacts with INADL (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q5VUT9 Q8N4I7 Q92808

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002232.2

ENSEMBL proteins:

ENSP00000357068

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNJ10)
	Human Recombinant Proteins from Abnova (KCNJ10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8995301
GO:0016020	membrane	IEA	--

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Antibodies for KCNJ10:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNJ10
	Sigma-Aldrich Antibodies for KCNJ10
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNJ10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNJ10)
	Novus Biologicals Antibodies for KCNJ10

Assays for KCNJ10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P78508

ProtoNet protein and cluster: P78508

2 Blocks protein families:

IPB001838 Inward rectifier K+ channel superfamily signature

IPB003269 Kir1.2 inward rectifier K+ channel signature

UniProtKB/Swiss-Prot: IRK10_HUMAN, P78508

Similarity: Belongs to the inward rectifier-type potassium channel family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNJ10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNJ10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002241

Applied Biosystems Silencer® siRNAs for KCNJ10

Sigma-Aldrich siRNA and siRNA Panels for KCNJ10

Sigma-Aldrich shRNA Panels and shRNA for KCNJ10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNJ10
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002241
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002241
untagged cDNA clone in CMV expression vector: NM_002241

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002241

UniProtKB/Swiss-Prot: IRK10_HUMAN, P78508

Function: May be responsible for potassium buffering action of glial cells in the brain. Inward

rectifier potassium channels are characterized by a greater tendency to allow potassium to flow

into the cell rather than out of it. Their voltage dependence is regulated by the concentration of

extracellular potassium; as external potassium is raised, the voltage range of the channel opening

shifts to more positive voltages. The inward rectification is mainly due to the blockage of

outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By

potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 10, Kir4.1

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnj10):

behavior/neurological	growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-postnatal
life span-post-weaning/aging	nervous system	vision/eye

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005267	potassium channel activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for KCNJ10

5/65 Interacting proteins for KCNJ10 (ENSP00000357068³) via UniProtKB, MINT, and/or STRING (see all 65 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARG	ENSP00000287820³	STRING (score=.926)
CA3	ENSP00000285381³	STRING (score=.924)
AQP4	ENSP00000372654³	STRING (score=.917)
NOS2	ENSP00000327251³	STRING (score=.915)
HSD11B1	ENSP00000355995³	STRING (score=.913)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	8995301

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNJ10

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNJ10 available from Tocris Bioscience

Compound	Action	CAS number
ZM 226600	KATP channel opener	[147695-92-9]
Minoxidil	K+ channel (KATP) opener	[38304-91-5]
PNU 37883 hydrochloride	Vascular KATP channel blocker	[57568-80-6]
Diazoxide	Blocks desensitization of AMPA receptors	[364-98-7]
Y-27152	Prodrug of KATP channel opener Y-26763; orally active in vivo	[127408-30-4]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNJ10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNJ10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002241

Sigma-Aldrich siRNA and siRNA Panels for KCNJ10

Sigma-Aldrich shRNA Panels and shRNA for KCNJ10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002241

REFSEQ mRNAs for KCNJ10 gene:

NM_002241.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002241

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002241
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002241
                                 untagged cDNA clone in CMV expression vector: NM_002241

Additional cDNA sequence:

AK312383.1 BC034036.1 BC037840.2 BC131627.1 U52155.1 U73193.1

4 DOTS entries:

DT.95136836 DT.87046294 DT.87046903 DT.92418513

24/75 AceView cDNA sequences (see all 75 ):

AI419228 AI361037 BX106837 NM_002241 AW071744 AI767375 AI631564 AW566005

AI422210 U73193 BM693480 AI422185 BQ028058 BQ636994 BP350144 AI948845

BX095323 AL583547 BF346344 AA873849 AL533380 BQ723125 AI634976 BC037840

highest scoring ESTs for KCNJ10:

U52155 AA348034 AI830426 BC034036 BG699206 BQ636994 BX095323 AA017020 AA021348 AA348033

Unigene Cluster for KCNJ10:

Potassium inwardly-rectifying channel, subfamily J, member 10

Hs.408960 [show with all ESTs]

Unigene Representative Sequence: NM_002241

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000368089

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KCNJ10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNJ10

¹ / ² / ³

8 probe-sets matching KCNJ10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
82525_at²^{, 3}	U95-D	1	1.00	1.00	0.97	1.49	AI939321	0.40	1.00	0.76	1
46631_at²^{, 3}	U95-B	1	1.00	1.00	0.99	0.93	AI830426	0.80	1.00	0.91	1
33951_at²^{, 3}	U95-A	1	0.88	1.00	0.96	0.69	U52155	1.00	1.00	1.00	1
46478_at²^{, 3}	U95-B	1	0.75	1.00	0.94	1.03	H15365	0.40	1.00	0.76	1
206692_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002241	0.60	1.00	0.82	1
228581_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW071744	0.60	1.00	0.82	1
206692_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228581_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNJ10 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGCTTTTG

SOURCE GeneReport for Unigene cluster: Hs.408960
Expression variation in blood from EXPOLDB for KCNJ10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNJ10 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNJ10¹	--	potassium inwardly-rectifying channel, subfamily J, more	89.71(n) 98.42(a)	488635 XM_545752.2 XP_545752.2
chimpanzee (Pan troglodytes)	KCNJ10¹	--	potassium inwardly-rectifying channel, subfamily J, more	99.65(n) 100(a)	457431 XM_513920.2 XP_513920.2
cow (Bos taurus)	KCNJ10¹	--	potassium inwardly-rectifying channel, subfamily J, more	92.79(n) 98.68(a)	533343 XM_612721.3 XP_612721.3
rat (Rattus norvegicus)	Kcnj10¹	--	potassium inwardly-rectifying channel, subfamily J, more	88.13(n) 95.25(a)	29718 NM_031602.1 NP_113790.1
mouse (Mus musculus)	Kcnj10^{1, 5}	1 (93.50 cM)⁵	potassium inwardly-rectifying channel, subfamily J, more^{1, 5}	89.62(n)¹ 99.21(a)¹	16513¹ NM_001039484.1¹ NP_001034573.1¹ AB039879⁵ AF322631⁵ (see all 12)

About this table Species with no ortholog for KCNJ10

ENSEMBL Gene Tree for KCNJ10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for KCNJ10 gene

KCNJ15² KCNJ13²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/190 NCBI SNPs in KCNJ10 are shown (see all 190 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 79)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1053074^1,2	A,C,F,H,O	158275745(-)	`TGGTTT/GATTTG`	1	--	ut3¹		14		EA MN EU WA NA	2710
	rs2486253^1,2	A,C,F,H,O	158276043(-)	`CTAACG/TATATC`	1	--	ut3¹ ese³		11		EU EA WA NA	978
	rs1130183^1,2	C,F,H	158278136(-)	`CTCTTC/TGCAGT`	1	R/C	mis¹ ese³ trp³		10		MN EU EA WA NA	958
--	rs3795339^1,2	C,F,H	158278135(-)	`TCTTCG/ACAGTG`	1	H/R	mis¹ ese³		12		EA NA EU WA	2456
	rs17375748^1,2	C,F,H	158276775(+)	`TTGAGC/TATCCG`	1	--	ut3¹		15		NA EU EA WA	1380
	rs12067668^1,2	F,H	158276780(+)	`CATCCG/ATGTTA`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs2486254^1,2	C	158275767(-)	`CATTGG/CCAAGT`	1	--	ut3¹		3		NA	142
--	rs6696741^1,2	C	158307195(+)	`GTCCCA/CGGTGC`	1	--	ng3¹		0	--	--	--	--
	rs3806198^1,2	H	158306901(-)	`CGTCTC/TTTCAT`	1	--	ng3¹		5		EA EU WA	1914
	rs2820553^1,2	A,C,F,H,O	158279977(-)	`ATTTCT/CTTTTG`	1	--	int¹		7		EU EA WA NA	558

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HapMap Linkage Disequilibrium images for KCNJ10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602208 disorders: 612780

1 PharmGKB disease relationship for KCNJ10 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Epilepsy	CO GN	15120748

About this table

Genetic Association Database: KCNJ10
Human Genome Epidemiology Navigator: KCNJ10 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/25 PubMed articles for KCNJ10 gene (see all 25 ):

Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. (PubMed id 15120748)^{3, 6, 7} Buono R.J....Ferraro T.N. (2004)
Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PubMed id 8995301)^{2, 3, 4} Shuck M.E....Bienkowski M.J. (1997)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)^{2, 3} Kubo Y....Vandenberg C.A. (2005)
Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. (PubMed id 15725393)^{3, 6} Lenzen K.P....Sander T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians. (PubMed id 12401729)^{3, 6} Farook V.S....Prochazka M. (2002)
Co-expression of human Kir3 subunits can yield channels with different functional properties. (PubMed id 10659995)^{3, 4} Schoots O....Van Tol H.H.M. (1999)
Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1. (PubMed id 9367690)^{2, 3} Tada Y....Kurachi Y. (1997)
CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. (PubMed id 9647694)^{1, 3} Kurschner C.... Surmeier D.J. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3766	HGNC: 6256	AceView: KCNJ10	Ensembl:ENSG00000177807	euGenes: HUgn3766
ECgene: KCNJ10	H-InvDB: KCNJ10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNJ10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KCNJ10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNJ10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNJ10		Antibodies for KCNJ10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNJ10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for KCNJ10
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Antibodies for KCNJ10

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KCNJ10 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for KCNJ10

Summaries
for KCNJ10

Genomic Location
for KCNJ10

Proteins
for KCNJ10

Protein Domains/
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for KCNJ10

Gene Function
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Pathways & Interactions
for KCNJ10

Drugs & Compounds
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Transcripts
for KCNJ10

Expression
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Services
for KCNJ10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNJ10 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor KCNJ10

Summariesfor KCNJ10

Genomic Locationfor KCNJ10

Proteinsfor KCNJ10

Protein Domains/Familiesfor KCNJ10

Gene Functionfor KCNJ10

Pathways & Interactionsfor KCNJ10

Drugs & Compoundsfor KCNJ10

Transcriptsfor KCNJ10

Expression for KCNJ10

Orthologsfor KCNJ10

Paralogsfor KCNJ10

SNPs/Variantsfor KCNJ10

Disorders & Mutationsfor KCNJ10

Medical Newsfor KCNJ10

Publicationsfor KCNJ10

Search for KCNJ10

Genome Databases showing KCNJ10

Other Databases showing KCNJ10

Specialized Databases showing KCNJ10

Licensable Technologiesfor KCNJ10

Servicesfor KCNJ10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNJ10

Summaries
for KCNJ10

Genomic Location
for KCNJ10

Proteins
for KCNJ10

Protein Domains/
Families
for KCNJ10

Gene Function
for KCNJ10

Pathways & Interactions
for KCNJ10

Drugs & Compounds
for KCNJ10

Transcripts
for KCNJ10

Expression
for KCNJ10

Orthologs
for KCNJ10

Paralogs
for KCNJ10

SNPs/Variants
for KCNJ10

Disorders & Mutations
for KCNJ10

Medical News
for KCNJ10

Publications
for KCNJ10

Licensable Technologies
for KCNJ10

Services
for KCNJ10