Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KCNJ1 Gene

protein-coding   GIFtS: 66
GCID: GC11M128706

Potassium Inwardly-Rectifying Channel, Subfamily J, Member...

  See KCNJ1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 2     KIR1.12
ROMK12 3 5     ROMK2
Inward Rectifier K(+) Channel Kir1.12 3     ATP-Sensitive Inward Rectifier Potassium Channel 12
Potassium Channel, Inwardly Rectifying Subfamily J Member 12 3     Inwardly Rectifying K+ Channel2
ATP-Regulated Potassium Channel ROM-K2 3     

External Ids:    HGNC: 62551   Entrez Gene: 37582   Ensembl: ENSG000001517047   OMIM: 6003595   UniProtKB: P480483   

Export aliases for KCNJ1 gene to outside databases

Previous GC identifers: GC11M130709 GC11M130220 GC11M128741 GC11M128245 GC11M128213 GC11M124655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KCNJ1 Gene:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic
responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium
channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The
encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell.
Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt
wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNJ1 Gene:
KCNJ1 (potassium inwardly-rectifying channel, subfamily J, member 1) is a protein-coding gene. Diseases associated with KCNJ1 include bartter syndrome antenatal type 2, and bartter syndrome, type 2. GO annotations related to this gene include inward rectifier potassium channel activity and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is KCNJ4.

UniProtKB/Swiss-Prot: IRK1_HUMAN, P48048
Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels
are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their
voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised,
the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due
to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be
blocked by external barium

summary for KCNJ1 Gene:
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.

Gene Wiki entry for KCNJ1 (ROMK) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNJ1 gene promoter:
         MZF-1   GR   Pax-6   GR-beta   IRF-1   GR-alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNJ1 promoter sequence
   Search Chromatin IP Primers for KCNJ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNJ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24

KCNJ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNJ1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M128706:  view genomic region     (about GC identifiers)

Start:
128,706,210 bp from pter      End:
128,737,268 bp from pter
Size:
31,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IRK1_HUMAN, P48048 (See protein sequence)
Recommended Name: ATP-sensitive inward rectifier potassium channel 1  
Size: 391 amino acids; 44795 Da
Subunit: Interacts with SGK1 and SLC9A3R2/NHERF2
Secondary accessions: B2RMR4 Q6LD67
Alternative splicing: 3 isoforms:  P48048-1   P48048-2   P48048-3   

Explore the universe of human proteins at neXtProt for KCNJ1: NX_P48048

Explore proteomics data for KCNJ1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNJ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000211.1  NP_722448.1  NP_722449.3  NP_722450.1  NP_722451.1  

    ENSEMBL proteins: 
     ENSP00000376433   ENSP00000406320   ENSP00000316233   ENSP00000376432   ENSP00000316136  
     ENSP00000376434  
    Reactome Protein details: P48048

    KCNJ1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KCNJ1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KCNJ1
    GenScript Custom Purified and Recombinant Proteins Services for KCNJ1
    Novus Biologicals KCNJ1 Proteins
    Novus Biologicals KCNJ1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KCNJ1

     
    Search eBioscience for Proteins for KCNJ1 

    KCNJ1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KCNJ1
    OriGene Custom Antibody Services for KCNJ1
    Novus Biologicals KCNJ1 Antibodies
    Abcam antibodies for KCNJ1
    Cloud-Clone Corp. Antibodies for KCNJ1
    ThermoFisher Antibodies for KCNJ1
    LSBio Antibodies in human, mouse, rat for KCNJ1

    KCNJ1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KCNJ1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNJ1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KCNJ1
    Cloud-Clone Corp. CLIAs for KCNJ1
    Search eBioscience for ELISAs for KCNJ1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KCN: Potassium channels
    KCNJ: Voltage-gated ion channels / Potassium channels, Inwardly rectifying

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kir1.1
    Inwardly rectifying potassium channels

    4 InterPro protein domains:
     IPR003268 K_chnl_inward-rec_Kir1.1
     IPR014756 Ig_E-set
     IPR013518 K_chnl_inward-rec_Kir_cyto
     IPR016449 K_chnl_inward-rec_Kir

    Graphical View of Domain Structure for InterPro Entry P48048

    ProtoNet protein and cluster: P48048

    2 Blocks protein domains:
    IPB001838 Inward rectifier K+ channel superfamily signature
    IPB003268 Kir1.1 inward rectifier K+ channel signature


    UniProtKB/Swiss-Prot: IRK1_HUMAN, P48048
    Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily


    Find genes that share domains with KCNJ1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRK1_HUMAN, P48048
    Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels
    are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their
    voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised,
    the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due
    to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be
    blocked by external barium
    Enzyme regulation: Inhibited by WNK3

         Genatlas biochemistry entry for KCNJ1:
    potassium non voltage-gated channel,inwardly rectifying,subfamily J,member 1,ATP-regulated,expressed in the kidney
    in the apical membrane thick ascending limb of the loop of Henle regulating SLC12A1 functioning

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005242inward rectifier potassium channel activity IEA--
    GO:0005524ATP binding IEA--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA12086641
         
    Find genes that share ontologies with KCNJ1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNJ1:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnj1):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     integument  mortality/aging  renal/urinary system 

    Find genes that share phenotypes with KCNJ1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNJ1: Kcnj1tm1Ges Kcnj1tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNJ1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNJ1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNJ1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNJ1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat KCNJ1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate KCNJ1:
    hsa-miR-145* hsa-miR-548t hsa-miR-27a hsa-miR-936 hsa-miR-624* hsa-miR-27b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidKCNJ1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KCNJ1
    Predesigned siRNA for gene silencing in human, mouse, rat KCNJ1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KCNJ1

    Clone
    Products:
         
    OriGene clones in human, mouse for KCNJ1 (see all 27)
    OriGene ORF clones in mouse, rat for KCNJ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): KCNJ1 (NM_000220)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNJ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KCNJ1
    Browse ESI BIO Cell Lines and PureStem Progenitors for KCNJ1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IRK1_HUMAN, P48048: Cell membrane; Multi-pass membrane protein. Note=Phosphorylation at Ser-44 by SGK1 is
    necessary for its expression at the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS9015377
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with KCNJ1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KCNJ1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Inwardly rectifying K+ channels
    Inwardly rectifying K+ channels0.82
    Potassium transport channels0.00
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Potassium Channels
    Potassium Channels0.43
    4Salivary secretion
    Gastric acid secretion0.34
    5Potassium transporters inward current
    Potassium transporters inward current


    Find genes that share SuperPaths with KCNJ1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNJ1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNJ1
        Potassium transport channels

    1 PharmGKB Pathway for KCNJ1
        Diuretics Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for KCNJ1):
        Aldosterone-regulated sodium reabsorption
    Gastric acid secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KCNJ1: 
              Neuronal Ion Channels in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNJ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KCNJ1 (P480483 ENSP000003161364) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=3 STRING: ENSP00000262613
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    GOLGA3Q083783, ENSP000002047264I2D: score=1 STRING: ENSP00000204726
    IL16Q140053, ENSP000003029354I2D: score=1 STRING: ENSP00000302935
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0001894tissue homeostasis IEA--
    GO:0006813potassium ion transport TAS9015377
    GO:0007268synaptic transmission TAS--
    GO:0007588excretion TAS9015377

    Find genes that share ontologies with KCNJ1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNJ1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LevcromakalimKir6 (KATP) channel opener. Active enantiomer of cromakalim (Cat. No. 1377)[94535-50-9]
    DiazoxideBlocks desensitization of AMPA receptors[364-98-7]
    GlibenclamideKir6 (KATP) channel blocker[10238-21-8]
    P1075Potent Kir6 (KATP) channel opener[60559-98-0]
    Tertiapin-QSelective blocker of inward-rectifier K+ channels[252198-49-5]

    2 HMDB Compounds for KCNJ1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    PotassiumK+ (see all 16)7440-09-7--

    9 DrugBank Compounds for KCNJ1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GlycodiazineGlidiazine (see all 2)339-44-6targetother/unknown17139284 16263802 17016423 20434356 134717 17015627 16470247
    MinoxidilMinossidile [Italian] (see all 2)38304-91-5targetinducer1601843 9579735 16169954 17139284 17016423 9646008 18602898
    GlimepirideGlimepirid (see all 4)93479-97-1targetinhibitor12703060 17139284 17016423 12475777
    Tolazamide-- 1156-19-0targetinhibitor10354277 17139284 8799949 17016423
    Tolbutamide-- 64-77-7targetinhibitor9647478 10455193 11226127
    Acetohexamide-- 968-81-0targetinhibitor17139284 17016423
    BethanidineBetanidine (see all 2)55-73-2targetinhibitor3167688 2157221
    GlyburideApo-Glibenclamide (see all 4)10238-21-8targetinhibitor16263802 16470247
    Agmatine-- 306-60-5targetantagonist8922740

    1 IUPHAR Ligand for KCNJ1 (Kir1.1)    About this table
    LigandTypeActionAffinityPubmed IDs
    Ba2+
    Pore BlockerAntagonist7929082

    Selected Novoseek inferred chemical compound relationships for KCNJ1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 76.6 85 12547773 (4), 19710010 (3), 10793021 (2), 19458126 (2) (see all 41)
    chloride 56.2 7 17872384 (1), 12920401 (1), 10561751 (1), 19096086 (1)
    nacl 52.7 10 12684516 (1), 19587141 (1), 15998707 (1), 20375989 (1) (see all 8)
    lysine 52.5 7 15767585 (3), 8861938 (1)
    katp 44.9 5 15980413 (2), 9261988 (2), 12381730 (1)
    sodium 40.6 5 9261995 (1), 16785747 (1), 15987778 (1), 19706730 (1)
    pip2 39.6 4 10318968 (3)
    biotin 27.7 5 11719519 (2), 12221079 (1), 15767585 (1)
    atp 22.6 13 12381730 (4), 8710944 (2), 8770158 (2), 9707637 (1) (see all 6)
    serine 9.87 7 12221079 (4), 8683463 (1)

    1 PharmGKB related drug/compound annotation for KCNJ1 gene    About this table
    Drug/compound PharmGKB Annotation
    hydrochlorothiazideCA  



    Find genes that share compounds with KCNJ1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KCNJ1 gene (5 alternative transcripts): 
    NM_000220.4  NM_153764.2  NM_153765.2  NM_153766.2  NM_153767.3  

    Unigene Cluster for KCNJ1:

    Potassium inwardly-rectifying channel, subfamily J, member 1
    Hs.527830  [show with all ESTs]
    Unigene Representative Sequence: BC063109
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392665 ENST00000440599(uc001qeq.1) ENST00000324036 ENST00000392664
    ENST00000324003 ENST00000531562 ENST00000392666(uc001qeo.1 uc001qep.1 uc001qer.1 uc001qes.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KCNJ1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate KCNJ1:
    hsa-miR-145* hsa-miR-548t hsa-miR-27a hsa-miR-936 hsa-miR-624* hsa-miR-27b hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidKCNJ1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KCNJ1
    Predesigned siRNA for gene silencing in human, mouse, rat KCNJ1
    Clone
    Products:
         
    OriGene clones in human, mouse for KCNJ1 (see all 27)
    OriGene ORF clones in mouse, rat for KCNJ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): KCNJ1 (NM_000220)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNJ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KCNJ1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNJ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNJ1
      QuantiTect SYBR Green Assays in human, mouse, rat KCNJ1
      QuantiFast Probe-based Assays in human, mouse, rat KCNJ1

    Additional mRNA sequence: 

    AK290797.1 AK308032.1 AK308033.1 AK314267.1 BC063109.1 BC074752.2 BC136360.1 BC136361.1 
    S78737.1 U03884.1 U12541.1 U12542.1 U12543.1 U12544.1 U12545.1 

    5 DOTS entries:

    DT.92421395  DT.98131927  DT.92421389  DT.87046667  DT.95170907 

    Selected AceView cDNA sequences (see all 45):

    BX111481 AI474674 AI580376 NM_153767 NM_000220 U03884 AI478535 AW204788 
    U12544 NM_153766 BC074752 NM_153764 AW611523 NM_153765 BC063109 AA741359 
    U12541 U12545 BV199124 AW301626 AW271978 AI636094 AW615383 BE466312 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -           -                                       
    SP2:              -     -           -                                       
    SP3:                    -     -     -                                       
    SP4:              -                 -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for KCNJ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KCNJ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCTCCA
    KCNJ1 Expression
    About this image


    KCNJ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Loop of Henle Cells Loop of Henle
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
    KCNJ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNJ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527830

    UniProtKB/Swiss-Prot: IRK1_HUMAN, P48048
    Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain,
    heart and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KCNJ1: 
              Neuronal Ion Channels in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KCNJ1
    OriGene qSTAR qPCR primer pairs in human, mouse for KCNJ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNJ1
    QuantiTect SYBR Green Assays in human, mouse, rat KCNJ1
    QuantiFast Probe-based Assays in human, mouse, rat KCNJ1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KCNJ1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnj11 , 5 potassium inwardly-rectifying channel, subfamily J, more1, 5 86.79(n)1
    90.79(a)1
      9 (17.69 cM)5
    563791  NM_001168354.11  NP_001161826.11 
     323724185 
    chicken
    (Gallus gallus)
    Aves KCNJ11 potassium inwardly-rectifying channel, subfamily J, more 79.69(n)
    85.71(a)
      428236  XM_004947967.1  XP_004948024.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNJ16
    potassium inwardly-rectifying channel, subfamily J...
    81(a)
    1 ↔ 1
    GL343197.1(4325581-4326765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnj11 potassium inwardly-rectifying channel, subfamily J, more 72.76(n)
    83.87(a)
      100487609  XM_004916171.1  XP_004916228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635342 similar to potassium inwardly-rectifying channel, subfamily more 74.03(n)   394010  AY394568.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Irk33 inward rectifier potassium channel 33(a)   37A1   --


    ENSEMBL Gene Tree for KCNJ1 (if available)
    TreeFam Gene Tree for KCNJ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KCNJ1 gene
    KCNJ42  KCNJ92  KCNJ162  KCNJ82  KCNJ122  KCNJ152  KCNJ52  KCNJ62  
    KCNJ22  KCNJ102  KCNJ142  KCNJ32  KCNJ112  
    16 SIMAP similar genes for KCNJ1 using alignment to 1 protein entry:     IRK1_HUMAN:
    KCNJ15    KCNJ10    KCNJ3    KCNJ11    KCNJ5    KCNJ6
    KCNJ12    KCNJ8    KCNJ18    KCNJ9    kcnj12x    KCNJ14
    KCNJ4    KCNJ16    KCNJ2    KCNJ13

    Find genes that share paralogs with KCNJ1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KCNJ1 (see all 866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs591727781,2,,4
    C,FBartter syndrome 2 (BS2)4 pathogenic1128578195(+) GGCACA/GTGGCA 10 T M mis14Minor allele frequency- G:0.01NA EU 7139
    VAR_0015504
    Bartter syndrome 2 (BS2)4--see VAR_0015502 W C mis40--------
    VAR_0197264
    Bartter syndrome 2 (BS2)4--see VAR_0197262 S R mis40--------
    VAR_0015564
    Bartter syndrome 2 (BS2)4--see VAR_0015562 V G mis40--------
    VAR_0015534
    Bartter syndrome 2 (BS2)4--see VAR_0015532 V E mis40--------
    VAR_0015514
    Bartter syndrome 2 (BS2)4--see VAR_0015512 D H mis40--------
    VAR_0197244
    Bartter syndrome 2 (BS2)4--see VAR_0197242 N K mis40--------
    VAR_0364264
    A breast cancer sample4--see VAR_0364262 S F mis40--------
    VAR_0015524
    Bartter syndrome 2 (BS2)4--see VAR_0015522 P L mis40--------
    VAR_0197254
    Bartter syndrome 2 (BS2)4--see VAR_0197252 A V mis40--------

    HapMap Linkage Disequilibrium report for KCNJ1 (128706210 - 128737268 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNJ1: --
    Human Gene Mutation Database (HGMD): KCNJ1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNJ1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNJ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600359   
    OMIM disorders: 241200  
    UniProtKB/Swiss-Prot: IRK1_HUMAN, P48048
  • Bartter syndrome 2 (BS2) [MIM:241200]: An autosomal recessive disorder characterized by impaired salt
    reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis,
    and varying degrees of hypercalciuria. Bartter syndrome type 2 is a life-threatening condition beginning in
    utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark is a
    marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for KCNJ1:    
    About MalaCards
    bartter syndrome antenatal type 2    bartter syndrome, type 2    bartter disease    proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome
    gitelman syndrome    hypokalemia    hydranencephaly    pseudohypoaldosteronism type ii
    polyhydramnios

    7 diseases from the University of Copenhagen DISEASES database for KCNJ1:
    Bartter disease     Gitelman syndrome     Pseudohypoaldosteronism     Hypokalemia
    Polyhydramnios     Nephrocalcinosis     Hyperaldosteronism

    Find genes that share disorders with KCNJ1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KCNJ1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bartters syndrome 95.7 45 12589089 (3), 9848791 (3), 10878442 (2), 17401586 (2) (see all 29)
    hyperprostaglandin e syndrome 95.4 6 11318951 (1), 9587066 (1), 12911542 (1), 15895241 (1) (see all 5)
    bartter syndrome, classic 93.2 1 15056980 (1)
    gitelman syndrome 90.6 3 15980941 (1), 12911530 (1), 15056980 (1)
    pseudohypoaldosteronism 90.6 3 17401586 (1), 12589089 (1), 19448535 (1)
    metabolic alkalosis 81.6 1 9261995 (1)
    nephrocalcinosis 80.5 3 19096086 (2), 9519207 (1)
    hypercalciuria 80.5 1 9519207 (1)
    hyperkalemia 78 10 12640382 (2), 12589089 (2), 19448535 (2), 19096086 (2) (see all 5)
    hypokalemia 70.2 1 19448535 (1)

    Genatlas disease: KCNJ1
    Bartter syndrome characterized by an hypokalemic,hypochloremic metabolic alkalosis with
    hyperkaliury,hyperexcretion of prostaglandin E,hyperreninemia hyperaldosteronism with normal blood
    pressure,insensitivity to AGT2,and hyperplasia of juxtaglomerular apparatus,autosomal recessive. Presenting as an
    antenatal form with hydramnios prematurity and dehydration at birth and a classic form with failure to thrive

    Genetic Association Database (GAD): KCNJ1
    Human Genome Epidemiology (HuGE) Navigator: KCNJ1 (7 documents)

    Export disorders for KCNJ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KCNJ1 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with KCNJ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA. (PubMed id 8190102)1, 2, 3, 9 Yano H.... Takeda J. (Mol. Pharmacol. 1994)
    2. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. (PubMed id 12684516)1, 2, 9 Yoo D....Welling P.A. (J. Biol. Chem. 2003)
    3. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. (PubMed id 8841184)1, 2, 9 Simon D.B.... Lifton R.P. (Nat. Genet. 1996)
    4. Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. (PubMed id 18443236)1, 4, 9 Tobin M.D....Samani N.J. (Hypertension 2008)
    5. Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome: evidence for genetic heterogeneity. (PubMed id 9002665)1, 2, 9 Karolyi L....Hebert S.C. (Hum. Mol. Genet. 1997)
    6. A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. (PubMed id 9727001)1, 2, 9 Derst C.... Karschin A. (J. Biol. Chem. 1998)
    7. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)1, 4 Ji W....Lifton R.P. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3758 HGNC: 6255 AceView: KCNJ1 Ensembl:ENSG00000151704 euGenes: HUgn3758
    ECgene: KCNJ1 Kegg: 3758 H-InvDB: KCNJ1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KCNJ1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KCNJ1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNJ1 gene:
    Search GeneIP for patents involving KCNJ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KCNJ1   OriGene RNAi products in human, mouse, rat for KCNJ1  
     OriGene qPCR primer pairs and template standards for KCNJ1   OriGene Protein Over-expression Lysate for KCNJ1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KCNJ1  
     OriGene qSTAR qPCR primer pairs in human, mouse for KCNJ1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KCNJ1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNJ1   OriGene Custom Protein Services for KCNJ1  

     
     
     Block miRNA regulation of human, mouse, rat KCNJ1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KCNJ1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNJ1 Predesigned siRNA for gene silencing in human, mouse, rat KCNJ1
     QuantiFast Probe-based Assays in human, mouse, rat KCNJ1 QuantiTect SYBR Green Assays in human, mouse, rat KCNJ1
     PCR Arrays including human, mouse, rat KCNJ1 Search Chromatin IP Primers for KCNJ1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNJ1  GeneGlobe Interaction Network for KCNJ1
     Regulatory tfbs in KCNJ1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KCNJ1 GenScript cDNA clones with any tag delivered in your preferred vector for KCNJ1
     GenScript Custom Assay Services for KCNJ1 GenScript Custom overexpressing Cell Line Services for KCNJ1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KCNJ1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KCNJ1 antibodies
     KCNJ1 proteins
     KCNJ1 lysates
     Antibodies for KCNJ1
     See all of Abcam's Antibodies, Kits and Proteins for KCNJ1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KCNJ1
     Antibodies for KCNJ1
     ELISAs for KCNJ1
     CLIAs for KCNJ1



     Browse ESI BIO Cell Lines and PureStem Progenitors for KCNJ1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNJ1
     SwitchGear 3'UTR luciferase reporter plasmids for KCNJ1
     SwitchGear Promoter luciferase reporter plasmids for KCNJ1
     ThermoFisher Antibodies for KCNJ1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNJ1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNJ1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KCNJ1
     LSBio Antibodies in human, mouse, rat for KCNJ1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KCNJ1
      Search eBioscience for proteins for KCNJ1
      Search eBioscience for elisas for KCNJ1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KCNJ1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4