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Aliases & Descriptions for KCNIP4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CALP 1 , 2 , 3 KCHIP4 1 , 2 , 3 , 5 KChIP4 3 MGC44947 1 , 2 OTTHUMP00000158705 2
Descriptions A-type potassium channel modulatory protein 4 2 , 3 Calsenilin-like protein 2 , 3 Kv channel interacting protein 4 2 Potassium channel-interacting protein 4 2 , 3 potassium channel interacting protein 4 2
Search outside databases for aliases for KCNIP4 genePrevious GC identifers: GC04M020814 GC04M020419 GC04M020481
Summaries for KCNIP4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for KCNIP4 : This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interactingproteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of theKCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differfrom each other in the N-terminus. They are integral subunit components of native Kv4 channelcomplexes. They may regulate A-type currents, and hence neuronal excitability, in response tochanges in intracellular calcium. This protein member also interacts with presenilin. Multiplealternatively spliced transcript variants encoding distinct isoforms have been identified for thisgene. [provided by RefSeq] UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 Function : Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-typepotassium channels. Probably modulates channels density, inactivation kinetics and rate ofrecovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulatesKCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity)
Gene Wiki entry for KCNIP4
Genomic Location for KCNIP4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the KCNIP4 gene Entrez Gene cytogenetic band: 4p15.31 Ensembl cytogenetic band: 4p15.31 HGNC cytogenetic band: 4p15.32 KCNIP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M020407:
(about GC identifiers )
Start:
20,339,328 bp from pter
End:
21,559,472 bp from pter
Size:
1,220,145 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_006316.15 Proteins for KCNIP4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 (See
protein sequence )Recommended Name: Kv channel-interacting protein 4 Size : 250 amino acids; 28729 Da
Subunit : Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2.Interacts with KCND3, and the C-terminus of PSEN2 and probably PSEN1
Subcellular location : Cell membrane; Peripheral membrane protein (By similarity)
Secondary accessions : Q4W5G8 Q8NEU0 Q9BWT2 Q9H294 Q9H2A4Alternative splicing : 4 isoforms : Q6PIL6-1 Q6PIL6-2 Q6PIL6-3 Q6PIL6-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (6 alternative transcripts):
NP_001030175.1 NP_001030176.1 NP_079497.2 NP_671710.1 NP_671711.1 NP_671712.1 ENSEMBL proteins: ENSP00000371583 ENSP00000371585 ENSP00000371587 ENSP00000346408 ENSP00000371584 ENSP00000351892 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: KCNIP4 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA --
About this table Antibodies for KCNIP4: Assays for KCNIP4:
Protein
Domains/ Families for KCNIP4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q6PIL6 ProtoNet protein and cluster: Q6PIL6
1 Blocks protein family : IPB001125 Recoverin family signature UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 Domain : The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4current to a slowly inactivating delayed rectifier potassium current (By similarity) Similarity : Belongs to the recoverin familySimilarity : Contains 4 EF-hand domains
Gene Function for KCNIP4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_001035003 Applied Biosystems Silencer ® siRNAs for KCNIP4 Sigma-Aldrich siRNA and siRNA Panels for KCNIP4 Sigma-Aldrich shRNA for KCNIP4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_025221 UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 Function : Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-typepotassium channels. Probably modulates channels density, inactivation kinetics and rate ofrecovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulatesKCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity)
5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for KCNIP4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for KCNIP4 5/8 Interacting proteins for KCNIP4 (ENSP00000346408 3 Q6PIL6 1 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006811 ion transport
IEA -- GO:0006813 potassium ion transport
IEA --
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Drugs & Compounds for KCNIP4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for KCNIP4
Compounds for KCNIP4 available from Tocris Bioscience About this table 1 Novoseek chemical compound relationship for KCNIP4 gene
About this table
Transcripts for KCNIP4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_001035003 Sigma-Aldrich siRNA and siRNA Panels for KCNIP4 Sigma-Aldrich shRNA for KCNIP4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001035003 NM_001035004 NM_025221 NM_147181 NM_147182 NM_147183
REFSEQ mRNAs for KCNIP4 gene (6 alternative transcripts): NM_001035003.1 NM_001035004.1 NM_025221.5 NM_147181.3 NM_147182.3 NM_147183.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001035003 NM_001035004 NM_025221 NM_147181 NM_147182 NM_147183
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001035003  
Additional cDNA sequence: AF302044.1 AF305072.1 AF367023.1 AF367024.1 AF453246.1 AK125392.1 AK289661.1 AK289922.1 AK290998.1 AK294188.1 AK314058.1 AY029176.1 AY118170.1 BC032520.1 BC070479.1 BX648990.1 CR610239.1 DQ148487.1 DQ148488.1 DQ148489.1 DQ148490.1 DQ148491.1 DQ148492.1
16 DOTS entries : DT.40266676 DT.97839761 DT.100021290 DT.101978714 DT.40314511 DT.92070656 DT.75100795 DT.121236085 DT.70105270 DT.406311 DT.99928482 DT.121267611 DT.404476 DT.207225 DT.410002 DT.91971400
24/39 AceView cDNA sequences (see all 39
):CR610239 NM_147183 AL532800 BF962047 AI733308 BX452550 BX507673 BM450459 AF453246 BX648990 BI752159 AA953914 AI793333 BF593418 BX495592 AI352454 BC032520 AW197223 AF302044 AI744028 AI673323 AF305072 BI596848 AW003081
highest scoring ESTs for KCNIP4 :BX648990 AL711653 AF302044 AF305072 AF367023 AF367024 AF453246 AI732844 AL711728 AY029176
Unigene Cluster for KCNIP4: Kv channel interacting protein 4 Hs.655705 [show with all ESTs ] Unigene Representative Sequence: AK125392 GeneLoc Exon Structure 6 Ensembl transcripts including schematic representations : ENST00000382148
ENST00000382150
ENST00000382152
ENST00000354426
ENST00000382149
ENST00000359001
Expression for KCNIP4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KCNIP4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KCNIP4 1 / 2 / 3
5 probe-sets matching KCNIP4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TACACTGAAASOURCE GeneReport for Unigene cluster: Hs.655705 Expression variation in blood from EXPOLDB for KCNIP4
UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 Tissue specificity : Predominantly expressed in brain
Orthologs for KCNIP4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KCNIP4 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for KCNIP4 ENSEMBL Gene Tree for KCNIP4 Paralogs for KCNIP4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KCNIP4 gene KCNIP1 2
SNPs/Variants for KCNIP4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for KCNIP4 (up to first 250kb)
Disorders & Mutations for KCNIP4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608182 Human Genome Epidemiology Navigator: KCNIP4 (2 documents)
Medical News for KCNIP4 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KCNIP4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/18 PubMed articles for KCNIP4 gene (see all 18
): Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. (PubMed id 11847232) 1, 2, 3, 4 Morohashi Y....Iwatsubo T. (2002) Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. (PubMed id 11805342) 2, 3, 4 Holmqvist M.H.... An W.F. (2002) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 3, 4 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene. (PubMed id 17981209) 1, 3 Bonne A....Geurts van Kessel A. (2007) Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PubMed id 16112838) 1, 3 Pruunsild P. and Timmusk T. (2005) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 3 Trynka G....Wijmenga C. (2009) Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. (PubMed id 18957440) 3 Jerng H.H. and Pfaffinger P.J. (2008) Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826) 3 Uhl G.R....Lerman C. (2008) Calsenilin and CALP interact with the cytoplasmic tail of UDP-Gal:GA2/GM2/GD2 beta-1,3-galactosyltransferase. (PubMed id 18269347) 3 Quintero C.A....Maccioni H.J. (2008)
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Genome Databases showing KCNIP4
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KCNIP4
(According to HUGE )
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Specialized Databases showing KCNIP4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KCNIP4 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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