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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNIP4 Gene

protein-coding   GIFtS: 55
GCID: GC04M020814

Kv channel interacting protein 4
 Explore 6 diseases affiliated with
KCNIP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNIP4    

Aliases
for KCNIP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kv Channel Interacting Protein 41 2     Potassium Channel-Interacting Protein 42 3
KCHIP41 2 3 5     MGC449471
CALP1 2 3     Kv Channel-Interacting Protein 42
A-Type Potassium Channel Modulatory Protein 42 3     Potassium Channel Interacting Protein 42
Calsenilin-Like Protein2 3     KChIP43

External Ids:    HGNC: 300831   Entrez Gene: 803332   Ensembl: ENSG000001857747   OMIM: 6081825   UniProtKB: Q6PIL63   

Export aliases for KCNIP4 gene to outside databases

Previous GC identifers: GC04M020419 GC04M020481 GC04M020407 GC04M020078


Summaries
for KCNIP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNIP4:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which
belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding
proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit
components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in
response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6
Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.
Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a
calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By
similarity)

summary for KCNIP4:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNIP4


Genomic Views
for KCNIP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNIP4 gene promoter:
         COUP-TF1   COUP   FOXD3   Olf-1   Nkx2-5   HNF-4alpha1   AREB6   MEF-2A   COUP-TF   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNIP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNIP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNIP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.32

KCNIP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNIP4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M020814:  view genomic region     (about GC identifiers)

Start:
 20,730,239 bp from pter      End:
 21,950,422 bp from pter
Size:
 1,220,184 bases      Orientation:
 minus strand

Proteins
for KCNIP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6 (See protein sequence)
Recommended Name: Kv channel-interacting protein 4  
Size: 250 amino acids; 28729 Da
Subunit: Component of heteromultimeric potassium channels (By similarity). Interacts with KCND2. Interacts with KCND3,
and the C-terminus of PSEN2 and probably PSEN1
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q3YAB8 Q3YAB9 Q3YAC0 Q3YAC1 Q3YAC2 Q4W5G8 Q8NEU0 Q9BWT2 Q9H294 Q9H2A4
Alternative splicing: 5 isoforms:  Q6PIL6-1   Q6PIL6-2   Q6PIL6-3   Q6PIL6-4   Q6PIL6-5   

Explore the universe of human proteins at neXtProt for KCNIP4: NX_Q6PIL6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PIL6

    • KCNIP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001030175.1  NP_001030176.1  NP_079497.2  NP_671710.1  NP_671711.1  NP_671712.1  

    ENSEMBL proteins: 
     ENSP00000371583   ENSP00000399080   ENSP00000371585   ENSP00000398943   ENSP00000371587  
     ENSP00000423257   ENSP00000445321   ENSP00000351892  

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    Novus Biologicals KCNIP4 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNIP4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--


    KCNIP4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNIP4

    Protein Domains /
    Families
    for KCNIP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNIP4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q6PIL6

    ProtoNet protein and cluster: Q6PIL6

    1 Blocks protein family: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6
    Domain: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly
    inactivating delayed rectifier potassium current (By similarity)
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    Function
    for KCNIP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6
    Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.
    Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a
    calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By
    similarity)

    miRNA
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    hsa-miR-3689b hsa-miR-448 hsa-miR-3146 hsa-miR-4299 hsa-miR-421 hsa-miR-29a* hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: KCNIP4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005267potassium channel activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----


    KCNIP4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KCNIP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00


    1 BioSystems Pathway for KCNIP4 
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNIP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for KCNIP4 (Q6PIL63 ENSP000003989434) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNIP2Q9NS613, ENSP000004200404I2D: score=2 STRING: ENSP00000420040
    KCND2Q9NZV83, ENSP000003334964I2D: score=1 STRING: ENSP00000333496
    PSEN1P497683, ENSP000003263664I2D: score=1 STRING: ENSP00000326366
    PSEN2P498103, ENSP000003557474I2D: score=2 STRING: ENSP00000355747
    FAM120BQ96EK73, ENSP000004179704I2D: score=1 STRING: ENSP00000417970
    About this table

    Drugs & Compounds
    for KCNIP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNIP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNIP4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNIP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for KCNIP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 54.4 9 11847232 (1), 15806290 (1), 14980206 (1), 17981209 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNIP4 / KCIP4 

    Transcripts
    for KCNIP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNIP4 gene (6 alternative transcripts): 
    NM_001035003.1  NM_001035004.1  NM_025221.5  NM_147181.3  NM_147182.3  NM_147183.3  

    Unigene Cluster for KCNIP4:

    Kv channel interacting protein 4
    Hs.655705  [show with all ESTs]
    Unigene Representative Sequence: AK125392
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382148(uc021xms.1 uc003gqe.2 uc003gqf.1 uc003gqg.1 uc003gqh.1 uc003gqi.1 uc021xmt.1 uc021xmu.1)
    ENST00000447367 ENST00000382150 ENST00000413487 ENST00000382152 ENST00000509207
    ENST00000382149 ENST00000515786 ENST00000515373 ENST00000512102 ENST00000359001


    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNIP4 (see all 28):
    hsa-miR-3689b hsa-miR-448 hsa-miR-3146 hsa-miR-4299 hsa-miR-421 hsa-miR-29a* hsa-miR-205* hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmid: KCNIP4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNIP4 (see all 7)
    OriGene shRNA RFP: KCNIP4
    OriGene siRNA: KCNIP4
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): KCNIP4 (NM_147182)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNIP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNIP4

    Additional cDNA sequence: 

    AF302044.1 AF305072.1 AF367023.1 AF367024.1 AF453246.1 AK125392.1 AK289661.1 AK289922.1 
    AK290998.1 AK294188.1 AK314058.1 AY029176.1 AY118170.1 BC032520.1 BC070479.1 BX648990.1 
    DQ148487.1 DQ148488.1 DQ148489.1 DQ148490.1 DQ148491.1 DQ148492.1 

    16 DOTS entries:

    DT.40266676  DT.97839761  DT.100021290  DT.101978714  DT.40314511  DT.92070656  DT.75100795  DT.121236085 
    DT.99928482  DT.121267611  DT.404476  DT.207225  DT.400125  DT.406311  DT.410002  DT.91971400 

    24/39 AceView cDNA sequences (see all 39):

    CR610239 NM_147183 BX507673 AF453246 BI752159 BF962047 AA953914 BX452550 
    AL532800 AI733308 BM450459 BX648990 BF593418 AF302044 BC032520 AI793333 
    BX495592 AW197223 AI744028 AI352454 BI545982 NM_147181 AF367023 AF367024 

    GeneLoc Exon Structure


    Expression
    for KCNIP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNIP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACACTGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNIP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone

    See KCNIP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNIP4

    SOURCE GeneReport for Unigene cluster: Hs.655705

    UniProtKB/Swiss-Prot: KCIP4_HUMAN, Q6PIL6
    Tissue specificity: Predominantly expressed in brain

        SABiosciences Custom PCR Arrays for KCNIP4
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    In Situ
    Assay Products:     
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    Orthologs
    for KCNIP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNIP4 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNIP41 Kv channel interacting protein 4 86.27(n)
    96.76(a)    		   395239  NM_204555.1  NP_989886.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNIP46
    		 --
    		 89(a)
    		 1 ↔ 1
    		 5(75539776-75585542)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.168272 Xenopus laevis transcribed sequence with moderate similarity more 80.73(n)    BJ031683.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005369631 Kv channel-interacting protein 4-like 74.83(n)
    85.71(a)    		   100536963  XM_003199020.1  XP_003199068.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG426831 CG42683 52.2(n)
    48.94(a)    		   32063  NM_001201649.2  NP_001188578.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C16H3.16
    F21A10.16
    		 --
    		 31(a)
    28(a)
    		 many ↔ many
    many ↔ many
    		 X(17617751-17619382)
    X(10177178-10180599)


    ENSEMBL Gene Tree for KCNIP4 (if available)
    TreeFam Gene Tree for KCNIP4 (if available) 

    Paralogs
    for KCNIP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNIP4 gene
    HPCA2  KCNIP32  GUCA1A2  KCNIP12  RCVRN2  HPCAL12  GUCA1B2  NCALD2  
    KCNIP22  HPCAL42  NCS12  VSNL12  GUCA1C2  
    15 SIMAP similar genes for KCNIP4 using alignment to 3 protein entries:     KCIP4_HUMAN (see all proteins):
    KCNIP1    KCNIP2    KCNIP3    DKFZp781K1922    HPCA    HPCAL1
    NCALD    NCS1    HPCAL4    VSNL1    RCV1    RCVRN
    GUCA1A    GUCA1B    DKFZp686E1183

    KCNIP4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNIP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 50 variations for KCNIP4
         15/33 CNVs (see all 33): 91966 63772 32581 51362 6247 98648 3483 2505 62167 68688 22799 63771 63770 23073 98650
         15/17 Indels (see all 17): 91968 46619 46617 40608 34318 40607 27612 68689 46618 41655 46616 68687 12420 10887 40609
    Human Gene Mutation Database (HGMD): KCNIP4
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNIP4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNIP4

    Disorders / Diseases
    for KCNIP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNIP4 for disorders           About GeneDecksing

    OMIM gene information: 608182    OMIM disorders: --

    6 diseases for KCNIP4:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia/lymphoma    neuronitis
    leiomyosarcoma    leukemia

    Human Genome Epidemiology (HuGE) Navigator: KCNIP4 (6 documents)

    Export disorders for KCNIP4 gene to outside databases

    Publications
    for KCNIP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNIP4 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with KCNIP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of CALP/KChIP4, a novel EF- hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. (PubMed id 11847232)1, 2, 3, 9 Morohashi Y.... Iwatsubo T. (2002)
    2. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. (PubMed id 11805342)1, 2, 3 Holmqvist M.H.... An W.F. (2002)
    3. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PubMed id 16112838)1, 2, 9 Pruunsild P. and Timmusk T. (2005)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene. (PubMed id 17981209)1, 9 Bonne A....Geurts van Kessel A. (2007)
    7. RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neu rodegeneration. (PubMed id 21624954)1 Massone S....Pagano A. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Association of genetic polymorphisms with hepatotoxic ity in patients with childhood acute lymphoblastic leukemia or lymphoma. (PubMed id 20670164)1 Horinouchi M....Nakamura T. (2010)

    External Searches for KCNIP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KCNIP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80333 HGNC: 30083 AceView: KCNIP4 Ensembl:ENSG00000185774 euGenes: HUgn80333
    ECgene: KCNIP4 H-InvDB: KCNIP4

    Other Databases showing KCNIP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNIP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNIP4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNIP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNIP4 gene:
    Search GeneIP for patents involving KCNIP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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