V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

KCNIP3 Gene

protein-coding   GIFtS: 57

GC02P095326
Kv channel interacting protein 3, calsenilin
(Previous names: calsenilin, presenilin-binding protein, EF hand transcription factor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CSEN)
Services    

Aliases &
Descriptions
for KCNIP3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CSEN 2, 3
DREAM 1, 2, 3
KCHIP3 1, 2, 3
KChIP3 3
MGC18289 2
calsenilin 1
Descriptions
A-type potassium channel modulatory protein 3 2, 3
DRE-antagonist modulator 2, 3
Kv channel interacting protein 3 2
Kv channel interacting protein 3, calsenilin 2
Kv channel-interacting protein 3 3
calsenilin, presenilin-binding protein, EF hand
transcription factor 1, 2
potassium channel interacting protein 3 2
External Ids
HGNC: 155231
Entrez Gene: 308182
UniProtKB: Q9Y2W73
Ensembl: ENSG000001150417
Search outside databases for aliases for KCNIP3 gene

Summaries
for KCNIP3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for KCNIP3:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting
proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family
are small calcium binding proteins containing EF-hand-like domains. They are integral subunit
components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal
excitability, in response to changes in intracellular calcium. The encoded protein also functions
as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively
spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: CSEN_HUMAN, Q9Y2W7
Function: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together
with PSEN2 involved in modulation of beta-amyloid formation

Gene Wiki entry for KCNIP3 (Calsenilin)

Genomic Location
for KCNIP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNIP3 gene  

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q21.1

KCNIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095326:     (about GC identifiers)

Start:
 95,326,799 bp from pter
End:
 95,415,552 bp from pter
Size:
 88,754 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000002.10  NT_026970.9  

Proteins
for KCNIP3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CSEN_HUMAN, Q9Y2W7 (See protein sequence)
Recommended Name: Calsenilin  
Size: 256 amino acids; 29231 Da
Subunit: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component
of heteromultimeric potassium channels. Interacts with KCND2 and KCND3 (By similarity). Interacts
with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic
reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the
plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic
reticulum and Golgi
PDB structures from and Proteopedia :
2E6W (3D)    
Secondary accessions: Q53TJ5 Q96T40 Q9UJ84 Q9UJ85
Alternative splicing: 2 isoforms:  Q9Y2W7-1   Q9Y2W7-2   

Post-translational modifications:

  • Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity)1
  • Proteolytically cleaved by caspase-31
  • Phosphorylation at Ser-63 inhibits cleavage by CASP31
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001030086.1  NP_038462.1  


    ENSEMBL proteins: 
    ENSP00000366386 ENSP00000354261 ENSP00000295225 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CSEN)
    Human Recombinant Proteins from Abnova (KCNIP3)
                  OriGene Purified Recombinant Human Protein: KCNIP3 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005794 Golgi apparatus IEA--
    GO:0005829 cytosol IEA--
    About this table

    Antibodies for KCNIP3: 
    Invitrogen Antibodies for KCNIP3
    Millipore Mono- and Polyclonal Antibodies for the study of KCNIP3
    Sigma-Aldrich Antibodies for KCNIP3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (CSEN), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (KCNIP3)
    Novus Biologicals Antibodies for KCNIP3

    Assays for KCNIP3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for KCNIP3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR001125 Recoverin
     IPR011992 EF-Hand_type
     IPR002048 EF_hand_Ca_bd
     IPR018248 EF_hand
     IPR018249 EF_HAND_2


       GeneDecks  KCNIP3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y2W7

    ProtoNet protein and cluster: Q9Y2W7

    1 Blocks protein family: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: CSEN_HUMAN, Q9Y2W7
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains

    Gene Function
    for KCNIP3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (KCNIP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (KCNIP3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001034914

                  Applied Biosystems Silencer® siRNAs for KCNIP3

                  Sigma-Aldrich siRNA for KCNIP3  
                         Sigma-Aldrich shRNA for KCNIP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for KCNIP3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001034914
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001034914
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001034914 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_013434

    UniProtKB/Swiss-Prot: CSEN_HUMAN, Q9Y2W7
    Function: Calcium-dependent transcriptional repressor that binds to the DRE element of genes
    including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by
    binding to magnesium. Seems to be involved in nociception (By similarity)
    Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type
    potassium channels. Probably modulates channels density, inactivation kinetics and rate of
    recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates
    KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and probably KCND3 trafficking to the cell
    surface
    Function: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together
    with PSEN2 involved in modulation of beta-amyloid formation

    4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnip3):

    behavior/neurologicalcellularnervous systemtouch/vibrissae

    5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS10078534
    GO:0003714 transcription corepressor activity TAS10078534
    GO:0005244 voltage-gated ion channel activity IEA--
    GO:0005267 potassium channel activity IEA--
    GO:0005509 calcium ion binding TAS10900016
    About this table

    Pathways & Interactions
    for KCNIP3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for KCNIP3 (Maps provided by GeneGo):
     The role of amyloid proteins in cell adhesion

       GeneDecks  KCNIP3 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  KCNIP3 


    5/9 Interacting proteins for KCNIP3 (ENSP000002952253 Q9Y2W72) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1ENSP000003263663STRING (score=.997)
    CREMENSP000003330553STRING (score=.986)
    PSEN2ENSP000003557463STRING (score=.958)
    TEAD3ENSP000003498283STRING (score=.884)
    KCNC1ENSP000002659693STRING (score=.881)
    About this table

    5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006350 transcription IEA--
    GO:0006811 ion transport IEA--
    GO:0006813 potassium ion transport IEA--
    GO:0006915 apoptosis IEA--
    About this table

    Drugs & Compounds
    for KCNIP3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for KCNIP3
    Browse Small Molecules at Sigma-Aldrich

    Compounds for KCNIP3 available from Tocris Bioscience
    CompoundAction CAS number
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    SG 209K+ channel opener[83440-03-3]
    4-AminopyridineK+ channel blocker[504-24-5]
    About this table


    4 Novoseek chemical compound relationships for KCNIP3 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 49.05 6 17102134 (2), 12667101 (1), 15763173 (1), 17962406 (1) (see all 5)
    calcium 45.98 41 10900016 (4), 15086516 (4), 17962406 (2), 18393943 (2) (see all 14)
    threonine 14.93 1 12837631 (1)
    oligonucleotide 6.71 1 12409095 (1)
    About this table


    Transcripts
    for KCNIP3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (KCNIP3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (KCNIP3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001034914

                  Sigma-Aldrich siRNA for KCNIP3  
                         Sigma-Aldrich shRNA for KCNIP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001034914  NM_013434  

    REFSEQ mRNAs for KCNIP3 gene (2 alternative transcripts): 

    NM_001034914.1   NM_013434.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001034914  NM_013434  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001034914
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001034914
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001034914 

    Additional cDNA sequence: 

    AB209076.1 AF120102.1 AF199599.1 AF367022.1 AK025847.1 AK026052.1 AK095539.1 AK315437.1 
    BC012850.1 BC019877.2 BT020075.1 DQ148485.1 DQ148486.1 

    9 DOTS entries:

    DT.445196  DT.434125  DT.97820366  DT.120985719  DT.120985703  DT.120985702  DT.75101966  DT.97836794 
    DT.86840430 

    24/101 AceView cDNA sequences (see all 101 ):

    AA349364 BX279924 AK095539 AW298517 AW450942 AA349363 BF374876 AA861334 
    AI365501 BC012850 BE222787 AI699155 AL039635 AK026052 AL540923 AF199599 
    AF120102 NM_013434 AK025847 BU689479 T87627 BQ948338 BP348449 AI523747 

    highest scoring ESTs for KCNIP3:

    AL118854 AA233601 AA349363 AA349364 AA349365 AF120102 AF199599 AF367022 AI094427 AI365501 

    Unigene Cluster for KCNIP3:

    Kv channel interacting protein 3, calsenilin
    Hs.437376  [show with all ESTs]
    Unigene Representative Sequence: AB209076


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000377181  ENST00000360990  ENST00000295225  

    Expression
    for KCNIP3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    KCNIP3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for KCNIP3

    1 / 2 / 3

    10 probe-sets matching KCNIP3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59964_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AL118854 1.00 1.00 1.00 1

    		78854_at2, 3 U95-E 1 1.00 1.00 0.41 0.57 AI523747 0.80 1.00 0.91 1

    		231774_at2, 3 U133-B 1 1.00 1.00 -- -- R17174 0.60 1.00 0.82 1

    		233688_at2, 3 U133-B 1 1.00 1.00 -- -- AK025847 0.60 1.00 0.82 1

    		228269_x_at2, 3 U133-B 1 1.00 1.00 -- -- AL568652 0.60 1.00 0.82 1

    		231774_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1555694_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		233688_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		228269_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1569355_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    GeneDecks  KCNIP3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.437376

    UniProtKB/Swiss-Prot: CSEN_HUMAN, Q9Y2W7
    Tissue specificity: Highly expressed in brain. Widely expressed at lower levels. Expression levels
    are elevated in brain cortex regions affected by Alzheimer disease

    Orthologs
    for KCNIP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for KCNIP3 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 KCNIP31   -- Kv channel interacting protein 3, calsenilin 91.02(n)
    94.14(a)    		 609135  XM_859418.1  XP_864511.1 
    chimpanzee
    (Pan troglodytes)    		 KCNIP31   -- Kv channel interacting protein 3, calsenilin 99.48(n)
    99.61(a)    		 459401  XM_515619.2  XP_515619.1 
    cow
    (Bos taurus)    		 KCNIP31   -- Kv channel interacting protein 3, calsenilin 90.89(n)
    93.36(a)    		 513316  NM_001075612.1  NP_001069080.1 
    rat
    (Rattus norvegicus)    		 Kcnip31   -- Kv channel interacting protein 3, calsenilin 88.02(n)
    92.97(a)    		 65199  NM_032462.1  NP_115851.1 
    mouse
    (Mus musculus)    		 Kcnip31, 5 25
    		 Kv channel interacting protein 3, calsenilin1, 5 87.63(n)1
    91.8(a)1    		 564611  NM_019789.21  NP_062763.21 
     AF1846245  AF2740505  (see all 21)
    About this table        Species with no ortholog for KCNIP3

    ENSEMBL Gene Tree for KCNIP3

    Paralogs
    for KCNIP3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for KCNIP3 gene
    EFCAB12  KCNIP22  

    SNPs/Variants
    for KCNIP3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/287 NCBI SNPs in KCNIP3 are shown (see all 287 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 90)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs67505421,2
    		A,C,F,H95375565(+) ACGCGG/CGTTTC 2 -- ng51 int14Minor allele frequency- C:0.24EU EA WA 418
    rs37555251,2
    		A,C,F,H95326275(-) TCACAC/GACACA 1 -- ng515Minor allele frequency- G:0.30EA EU WA 1166
    rs67305871,2
    		F,H95413793(+) AGGCTG/ACCTCT 2 -- ut31 ese34Minor allele frequency- A:0.10EU EA WA 418
    rs18628981,2
    		C95375258(-) AGGCGG/TGGCCG 2 -- ng51 int10--------
    rs356586701,2
    		F95404372(+) TTACGC/TGCAGT 2 A/V mis11Minor allele frequency- T:0.03NA 60
    rs116741351,2
    		C95326841(+) TGCCAG/TCCGGC 1 -- ut51 ese30--------
    --
    rs75574141,2
    		C95326686(+) GGAGAC/GAGAGA 1 -- ng51 trp30--------
    rs355168571,2
    		C95339930(+) CAGCCG/ACCAGG 1 H/R mis11Minor allele frequency- A:0.01NA 78
    --
    rs37555261,2
    		C95325144(-) ggctaA/Cttttt 1 -- ng510--------
    rs118956351,2
    		C,H95339841(+) ACAAAG/AGCGTC 1 K/K syn1 ese34Minor allele frequency- A:0.00EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for KCNIP3 (up to first 250kb)

    Disorders & Mutations
    for KCNIP3

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604662

    1 Novoseek disease relationship for KCNIP3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 31.29 13 15770150 (6), 11072133 (2), 14720210 (2)
    About this table

    Genetic Association Database: KCNIP3

    Medical News
    for KCNIP3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for KCNIP3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/62 PubMed articles for KCNIP3 gene (see all 62 ):

    Search for KCNIP3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNIP3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 30818 HGNC: 15523 AceView: CSEN Ensembl:ENSG00000115041 euGenes: HUgn30818
    ECgene: KCNIP3 H-InvDB: KCNIP3

    Other Databases showing KCNIP3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing KCNIP3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for KCNIP3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for KCNIP3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for KCNIP3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for KCNIP3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for KCNIP3 Antibodies for KCNIP3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for KCNIP3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (KCNIP3)
     Antibodies (KCNIP3)
     Chimera RNAi (KCNIP3)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (CSEN)
     Antibodies (CSEN)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Tocris compounds for KCNIP3




     Drugs for KCNIP3
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for KCNIP3

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    KCNIP3 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com