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KCNIP2 Gene

protein-coding   GIFtS: 55
GCID: GC10M103575

Kv Channel Interacting Protein 2

(Previous name: Kv channel-interacting protein 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kv Channel Interacting Protein 21 2     KCHIP22 3
Kv Channel-Interacting Protein 21 2     A-Type Potassium Channel Modulatory Protein 22 3
Cardiac Voltage-Gated Potassium Channel Modulatory Subunit2 3     KChIP23
Potassium Channel-Interacting Protein 22 3     

External Ids:    HGNC: 155221   Entrez Gene: 308192   Ensembl: ENSG000001200497   OMIM: 6046615   UniProtKB: Q9NS613   

Export aliases for KCNIP2 gene to outside databases

Previous GC identifers: GC10M102478 GC10M102819 GC10M103716 GC10M103250 GC10M097216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNIP2 Gene:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs),
which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium
binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are
integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence
neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript
variants encoding distinct isoforms have been identified from this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNIP2 Gene:
KCNIP2 (Kv channel interacting protein 2) is a protein-coding gene. GO annotations related to this gene include protein N-terminus binding and calcium ion binding. An important paralog of this gene is HPCA.

UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61
Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.
Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a
calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved
in KCND2 and KCND3 trafficking to the cell surface (By similarity)

summary for KCNIP2 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNIP2 gene promoter:
         Sp1   NRSF form 1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNIP2 promoter sequence
   Search Chromatin IP Primers for KCNIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

KCNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNIP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M103575:  view genomic region     (about GC identifiers)

Start:
103,585,731 bp from pter      End:
103,603,677 bp from pter
Size:
17,947 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61 (See protein sequence)
Recommended Name: Kv channel-interacting protein 2  
Size: 270 amino acids; 30907 Da
Subunit: Component of heteromultimeric potassium channels. The KCND2-KCNIP2 channel complex contains four KCND2
and four KCNIP2 subunits. Interacts with KCND2. Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably
part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can
self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent
manner
Secondary accessions: A6NJE5 A8MQ75 Q3YAC6 Q3YAC8 Q3YAC9 Q7Z6F1 Q96K86 Q96T41 Q96T42 Q96T43
Q96T44 Q9H0N4 Q9HD10 Q9HD11 Q9NS60 Q9NY10 Q9NZI1
Alternative splicing: 9 isoforms:  Q9NS61-1   Q9NS61-2   Q9NS61-3   Q9NS61-4   Q9NS61-5   Q9NS61-6   Q9NS61-7   Q9NS61-8   
Q9NS61-9   

Explore the universe of human proteins at neXtProt for KCNIP2: NX_Q9NS61

Explore proteomics data for KCNIP2 at MOPED

Post-translational modifications: 

  • Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_055406.2  NP_775283.1  NP_775284.1  NP_775285.1  NP_775286.1  NP_775287.1  NP_775289.1  

    ENSEMBL proteins: 
     ENSP00000239118   ENSP00000349055   ENSP00000359063   ENSP00000411679   ENSP00000341624  
     ENSP00000420040   ENSP00000344169   ENSP00000239117   ENSP00000350733  

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    Cloud-Clone Corp. Proteins for KCNIP2

     
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    antibodies-online peptides for KCNIP2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9NS61

    ProtoNet protein and cluster: Q9NS61

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with KCNIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCIP2_HUMAN, Q9NS61
    Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.
    Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a
    calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved
    in KCND2 and KCND3 trafficking to the cell surface (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005250A-type (transient outward) potassium channel activity TAS11287421
    GO:0005509calcium ion binding TAS11287421
    GO:0005515protein binding IPI15358149
    GO:0015459potassium channel regulator activity IDA--
    GO:0042802identical protein binding IPI15358149
         
    Find genes that share ontologies with KCNIP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KCNIP2:
     Increased number of cells in m  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Kcnip2):
     cardiovascular system 

    Find genes that share phenotypes with KCNIP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcnip2tm1Krc for KCNIP2

       genOway: Develop your customized and physiologically relevant rodent model for KCNIP2

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    hsa-miR-330-5p hsa-miR-631 hsa-miR-29a hsa-miR-578 hsa-miR-3921 hsa-miR-4274 hsa-miR-326 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidKCNIP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCIP2_HUMAN, Q9NS61: Isoform 1: Cell membrane; Lipid-anchor (By similarity)
    KCIP2_HUMAN, Q9NS61: Isoform 2: Cell membrane; Lipid-anchor (By similarity)
    KCIP2_HUMAN, Q9NS61: Isoform 6: Cell membrane; Lipid-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005737cytoplasm IDA11287421
    GO:0008076voltage-gated potassium channel complex NAS11287421

    Find genes that share ontologies with KCNIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNIP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Antiarrhythmic Pathway, Pharmacodynamics
    Antiarrhythmic Pathway, Pharmacodynamics



    1 PharmGKB Pathway for KCNIP2
        Antiarrhythmic Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNIP2
    Interactions:

        GeneGlobe Interaction Network for KCNIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KCNIP2 (Q9NS611, 3 ENSP000004200404) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCND2Q9NZV81, 3, ENSP000003334964EBI-1053010,EBI-1646745 I2D: score=3 STRING: ENSP00000333496
    KCND3Q9UK173, ENSP000003195914I2D: score=1 STRING: ENSP00000319591
    KCNIP1Q9NZI21, ENSP000003953234EBI-1053010,EBI-2120635 STRING: ENSP00000395323
    KCNIP4Q6PIL63I2D: score=2 
    EIF6ENSP000003635594STRING: ENSP00000363559
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005513detection of calcium ion TAS10676964
    GO:0006813potassium ion transport TAS11287421
    GO:0006936muscle contraction NAS11287421
    GO:0007165signal transduction TAS10676964
    GO:0007268synaptic transmission NAS11287421

    Find genes that share ontologies with KCNIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for KCNIP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    2 HMDB Compounds for KCNIP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PotassiumK+ (see all 16)7440-09-7--

    1 Novoseek inferred chemical compound relationship for KCNIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 56.8 3 15107477 (1), 18536731 (1), 17242957 (1)



    Find genes that share compounds with KCNIP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNIP2 gene (8 alternative transcripts): 
    NM_014591.4  NM_173191.2  NM_173192.2  NM_173193.2  NM_173194.2  NM_173195.2  NM_173197.2  NM_173342.2  

    Unigene Cluster for KCNIP2:

    Kv channel interacting protein 2
    Hs.97044  [show with all ESTs]
    Unigene Representative Sequence: NM_014591
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348850(uc001ktx.3 uc001kty.3 uc001ktz.3 uc010qqh.2)
    ENST00000355657(uc010qqg.2 uc001kuc.3 uc009xwv.3 uc001kub.3 uc001kue.3 uc001kud.3 uc001kuf.3 uc001kua.3 uc009xwu.3)
    ENST00000356640 ENST00000460388 ENST00000370046 ENST00000472764 ENST00000434163
    ENST00000353068 ENST00000461105 ENST00000343195 ENST00000239117 ENST00000483385
    ENST00000358038(uc010qqi.2)
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    Additional mRNA sequence: 

    AF199598.1 AF295076.1 AF295530.1 AF347114.1 AF367018.1 AF367019.1 AF367020.1 AF367021.1 
    AJ276317.1 AK027347.1 AK055089.1 AK094668.1 AK295324.1 AK301433.1 AK309368.1 AK314536.1 
    AK315042.1 AL136722.1 AY026328.1 AY302141.1 BC034685.1 DQ148480.1 DQ148481.1 DQ148482.1 
    DQ148483.1 DQ148484.1 DQ862463.1 

    15 DOTS entries:

    DT.100024646  DT.95167614  DT.92421414  DT.100024645  DT.97841042  DT.100786537  DT.100682704  DT.97841043 
    DT.100024644  DT.121246693  DT.97801229  DT.121246726  DT.95083018  DT.100786536  DT.95289238 

    Selected AceView cDNA sequences (see all 77):

    NM_173191 AY026328 NM_173195 AA365784 BX385910 BE048040 NM_173342 AI871184 
    BX105471 NM_173194 AF367019 AF367020 BF347736 AA758605 AI824965 AF347114 
    AF367018 AF295076 AF199598 AK027347 NM_173197 AW959983 CR610606 NM_014591 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNIP2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:        -     -                 -                 -           -                                                     -                                 
    SP2:        -     -                 -     -           -           -     -                                               -                                 
    SP3:        -     -                 -     -     -     -           -     -                                               -                                 
    SP4:                                                  -           -     -                                               -                                 
    SP5:                    -     -     -     -     -     -           -     -                                               -                                 


    ECgene alternative splicing isoforms for KCNIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCCACCCC
    KCNIP2 Expression
    About this image


    KCNIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Olfactory Bulb   
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Heart (Cardiovascular System)
    KCNIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97044

    UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61
    Tissue specificity: Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and
    hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not
    expressed in fetal heart

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KCNIP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnip21 , 5 Kv channel-interacting protein 21, 5 92.35(n)1
    96.67(a)1
      19 (38.75 cM)5
    809061  NM_145703.21  NP_663749.11 
     457918395 
    chicken
    (Gallus gallus)
    Aves KCNIP21 Kv channel interacting protein 2 83.73(n)
    92.86(a)
      374098  NM_204250.1  NP_989581.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNIP26
    Kv channel interacting protein 2
    88(a)
    1 ↔ 1
    GL343239.1(1356345-1515876)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnip21 Kv channel interacting protein 2 78.31(n)
    90.08(a)
      100494608  XM_004915859.1  XP_004915916.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000039471 novel protein similar to H.sapiens Kv channel-interacting more 67.59(n)
    67.46(a)
      100003947  XM_003201139.2  XP_003201187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58903 calcium ion binding 49(a)   96F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ncs-76
    ncs-46
    Protein NCS-4, isoform a
    35(a)
    27(a)
    many ↔ many
    many ↔ many
    X(17617827-17619458) WBGene00015867
    X(10177237-10180659) WBGene00008998
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FRQ16
    N-myristoylated calcium-binding protein that may h...
    40(a)
    1 → many
    IV(1222759-1223331) YDR373W


    ENSEMBL Gene Tree for KCNIP2 (if available)
    TreeFam Gene Tree for KCNIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNIP2 gene
    HPCA2  KCNIP32  KCNIP42  KCNIP12  GUCA1A2  RCVRN2  HPCAL12  GUCA1B2  
    NCALD2  HPCAL42  NCS12  GUCA1C2  VSNL12  
    15 SIMAP similar genes for KCNIP2 using alignment to 4 protein entries:     KCIP2_HUMAN (see all proteins):
    KCNIP1    KCNIP4    KCNIP3    NCALD    VSNL1    RCVRN
    HPCA    HPCAL1    DKFZp781K1922    NCS1    HPCAL4    GUCA1B
    GUCA1A    DKFZp686E1183    GUCA1C

    Find genes that share paralogs with KCNIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNIP2 (see all 337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719663351,2
    C--97221173(+) ACGCC-/CACACAC 7 -- int10--------
    rs57874461,2
    C,F--97231041(+) CCGCAC/-CCCCC 7 -- int1 us2k1 trp33Minor allele frequency- -:0.50NA 6
    rs600891511,2
    C--103594910(+) AGGGT-/GGGT  
            
    CTACT
    7 -- int10--------
    rs1910952001,2
    --103947421(+) GGAAGC/TTGACG 6 -- ds50010--------
    rs348232271,2
    C,F--103947501(+) CTGGGC/TGAAAG 6 -- ds50013Minor allele frequency- T:0.50NA 6
    rs1441988201,2
    --103947727(+) GGAGAC/TTCATG 6 -- ds50010--------
    rs1507002471,2
    --103948076(+) GCTAAA/GTGGGA 6 -- ut310--------
    rs764537951,2
    C,F--103948148(+) GGTCCT/CATGGT 6 -- ut311Minor allele frequency- C:0.02EA 120
    rs1821137591,2
    --103948194(+) GTAGAC/TTGAGT 6 -- ut310--------
    rs1877873851,2
    --103948348(+) GCATCC/TACTGT 6 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNIP2 (103585731 - 103603677 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNIP2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604661    OMIM disorders: --


    Find genes that share disorders with KCNIP2           About GenesLikeMe

    Genetic Association Database (GAD): KCNIP2
    Human Genome Epidemiology (HuGE) Navigator: KCNIP2 (1 document)

    Export disorders for KCNIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNIP2 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with KCNIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Modulation of A-type potassium channels by a family of calcium sensors. (PubMed id 10676964)1, 2, 3 An W.F.... Rhodes K.J. (Nature 2000)
    2. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. (PubMed id 11263977)1, 2, 9 Ohya S....Imaizumi Y. (Biochem. Biophys. Res. Commun. 2001)
    3. Modulation of Kv4.3 current by accessory subunits. (PubMed id 12297301)1, 2, 9 Deschenes I. and Tomaselli G.F. (FEBS Lett. 2002)
    4. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PubMed id 16112838)1, 2, 9 Pruunsild P. and Timmusk T. (Genomics 2005)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. (PubMed id 14980201)1, 2 Kim L.A....Grigorieff N. (Neuron 2004)
    8. Ito channels are octameric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. (PubMed id 14623880)1, 2 Kim L.A.... Goldstein S.A. (J. Biol. Chem. 2004)
    9. Protein-protein interactions of KChIP proteins and Kv4.2. (PubMed id 15358149)1, 2 Lin Y.-L.... Chang L.S. (Biochem. Biophys. Res. Commun. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30819 HGNC: 15522 AceView: KCNIP2 Ensembl:ENSG00000120049 euGenes: HUgn30819
    ECgene: KCNIP2 H-InvDB: KCNIP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNIP2 gene:
    Search GeneIP for patents involving KCNIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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