V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

KCNIP2 Gene

protein-coding GIFtS: 57

GC10M103575

Kv channel interacting protein 2
(Previous name: Kv channel-interacting protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp566L1246 ^²
KCHIP2 ^¹, ², ³
KChIP2 ^³
MGC17241 ^²
OTTHUMP00000020332 ^²
OTTHUMP00000020333 ^²
OTTHUMP00000020336 ^²
OTTHUMP00000020337 ^²
OTTHUMP00000020339 ^²
OTTHUMP00000020340 ^²

Descriptions
A-type potassium channel modulatory protein 2 ^², ³
Cardiac voltage-gated potassium channel modulatory subunit ^³
Kv channel interacting protein 2 ^²
Kv channel-interacting protein 2 ^¹, ²
Potassium channel-interacting protein 2 ^³
cardiac voltage gated potassium channel modulatory subunit ^²
potassium channel interacting protein 2 ^²

External Ids
HGNC: 15522¹
Entrez Gene: 30819²
UniProtKB: Q9NS61³
Ensembl: ENSG00000120049⁷

Search outside databases for aliases for KCNIP2 gene

Previous GC identifers: GC10M102478 GC10M102819 GC10M103716 GC10M103250

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNIP2:

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting

proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of

the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and

differ from each other in the N-terminus. They are integral subunit components of native Kv4

channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response

to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding

distinct isoforms have been identified from this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61

Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type

potassium channels. Probably modulates channels density, inactivation kinetics and rate of

recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates

KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface

(By similarity)

Gene Wiki entry for KCNIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNIP2 gene

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.32 HGNC chromosome: 10

KCNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M103575: (about GC identifiers)

Start:	103,575,721 bp from pter
End:	103,593,667 bp from pter
Size:	17,947 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61 (See protein sequence)

Recommended Name: Kv channel-interacting protein 2

Size: 270 amino acids; 30919 Da

Subunit: Component of heteromultimeric potassium channels. The KCND2-KCNIP2 channel complex

contains four KCND2 and four KCNIP2 subunits. Interacts with KCND2. Isoform 1 and isoform 3

interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3

and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and

homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner

Subcellular location: Isoform 1: Cell membrane; Lipid-anchor (By similarity)

Subcellular location: Isoform 2: Cell membrane; Lipid-anchor (By similarity)

Subcellular location: Isoform 6: Cell membrane; Lipid-anchor (By similarity)

Secondary accessions: Q7Z6F1 Q96K86 Q96T41 Q96T42 Q96T43 Q96T44 Q9H0N4 Q9HD10 Q9HD11 Q9NS60 Q9NY10

Q9NZI1

Alternative splicing: 9 isoforms: Q9NS61-1 Q9NS61-2 Q9NS61-3 Q9NS61-4 Q9NS61-5 Q9NS61-6 Q9NS61-7 Q9NS61-8

Q9NS61-9

Post-translational modifications:

Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (7 alternative transcripts):

NP_055406.2 NP_775283.1 NP_775284.1 NP_775285.1 NP_775286.1 NP_775287.1 NP_775289.1

ENSEMBL proteins:

ENSP00000344169 ENSP00000341624 ENSP00000350733 ENSP00000349055 ENSP00000347877 ENSP00000352940

ENSP00000359063 ENSP00000239118 ENSP00000286993 ENSP00000239117 ENSP00000359076

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KChIP2)
	Human Recombinant Proteins from Abnova (KCNIP2)

OriGene Purified Recombinant Human Protein: KCNIP2

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11287421
GO:0005886	plasma membrane	IEA	--
GO:0008076	voltage-gated potassium channel complex	NAS	11287421

About this table

Antibodies for KCNIP2:

	Invitrogen Antibodies for KCNIP2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KCNIP2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KChIP2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for KCNIP2

Assays for KCNIP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NS61

ProtoNet protein and cluster: Q9NS61

1 Blocks protein family: IPB001125 Recoverin family signature

UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61

Similarity: Belongs to the recoverin family

Similarity: Contains 4 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNIP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNIP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_173191

Applied Biosystems Silencer® siRNAs for KCNIP2

Sigma-Aldrich siRNA and siRNA Panels for KCNIP2

Sigma-Aldrich shRNA Panels and shRNA for KCNIP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNIP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_014591
Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_014591
untagged cDNA clones in CMV expression vector (see all 8): NM_014591

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014591

UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61

Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type

potassium channels. Probably modulates channels density, inactivation kinetics and rate of

recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates

KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface

(By similarity)

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Kcnip2):

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005250	A-type (transient outward) potassium channel activity	TAS	11287421
GO:0005267	potassium channel activity	IEA	--
GO:0005509	calcium ion binding	TAS	11287421
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNIP2

5/49 Interacting proteins for KCNIP2 (ENSP00000347877³ Q9NS61¹) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCND2	Q9NZV8¹	STRING (score=.998) EBI-1053010, EBI-1646745
KCNIP1	Q9NZI2¹	EBI-1053010, EBI-2120635
KCNIP2	Q9NS61¹	EBI-1053003, EBI-1053003
KCNIP4	Q6PIL6¹	EBI-1052975, EBI-1051469
KCND3	ENSP00000319591³	STRING (score=.999)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005513	detection of calcium ion	TAS	10676964
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	11287421
GO:0006936	muscle contraction	NAS	11287421
GO:0007165	signal transduction	TAS	10676964

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNIP2 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener	[83440-03-3]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

1 Novoseek chemical compound relationship for KCNIP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	58.60	3	15107477 (1), 18536731 (1), 17242957 (1)

About this table

1 PharmGKB drug compound relationship for KCNIP2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA GN	12135940

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNIP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNIP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_173191

Sigma-Aldrich siRNA and siRNA Panels for KCNIP2

Sigma-Aldrich shRNA Panels and shRNA for KCNIP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014591 NM_173191 NM_173192 NM_173193 NM_173194 NM_173195 NM_173197

REFSEQ mRNAs for KCNIP2 gene (7 alternative transcripts):

NM_014591.4 NM_173191.2 NM_173192.2 NM_173193.2 NM_173194.2 NM_173195.2 NM_173197.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014591 NM_173191 NM_173192 NM_173193 NM_173194 NM_173195 NM_173197

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_014591
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_014591
                                 untagged cDNA clones in CMV expression vector (see all 8): NM_014591

Additional cDNA sequence:

AF199598.1 AF295076.1 AF295530.1 AF347114.1 AF367018.1 AF367019.1 AF367020.1 AF367021.1

AJ276317.1 AK027347.1 AK055089.1 AK094668.1 AK295324.1 AK301433.1 AK309368.1 AK314536.1

AK315042.1 AL136722.1 AY026328.1 AY302141.1 BC034685.1 CR599605.1 CR610606.1 DQ148480.1

DQ148481.1 DQ148482.1 DQ148483.1 DQ148484.1 DQ862463.1

15 DOTS entries:

DT.100024646 DT.95167614 DT.92421414 DT.100024645 DT.97841042 DT.100786537 DT.100682704 DT.97841043

DT.100024644 DT.121246693 DT.97801229 DT.121246726 DT.95083018 DT.100786536 DT.95289238

24/77 AceView cDNA sequences (see all 77 ):

AI871184 AF199598 NM_014591 AF295076 AK027347 BX105471 AA365784 AF367020

AF367018 NM_173197 BF347736 AF295530 NM_173194 NM_173193 AF347114 CR610606

BC034685 BE048040 AA365263 AW959983 AF367019 CR599605 AF367021 NM_173192

highest scoring ESTs for KCNIP2:

AF199598 AF295076 AF295530 AF347114 AF367018 AF367019 AF367021 AK055089 AL533488 AY026328

Unigene Cluster for KCNIP2:

Kv channel interacting protein 2

Hs.97044 [show with all ESTs]

Unigene Representative Sequence: NM_014591

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for KCNIP2 (see all 12 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b
SP1:			-		-						-						-				-																		-
SP2:			-		-						-		-				-				-		-																-
SP3:			-		-						-		-		-		-				-		-																-
SP4:																	-				-		-																-
SP5:							-		-		-		-		-		-				-		-																-

About this scheme

ECgene alternative splicing isoforms for KCNIP2

11 Ensembl transcripts including schematic representations:

ENST00000343195 ENST00000353068 ENST00000358038 ENST00000356640 ENST00000355657 ENST00000359877

ENST00000370046 ENST00000348850 ENST00000286993 ENST00000239117 ENST00000370059

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNIP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNIP2

¹ / ² / ³

8 probe-sets matching KCNIP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48950_at²^{, 3}	U95-B	2	1.00	0.97	1.00	1.00	F36908	0.80	1.00	0.91	1
224528_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB044584	0.40	1.00	0.76	1
223727_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL136722	0.60	1.00	0.82	1
221321_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014591	0.60	1.00	0.82	1
1555230_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224528_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223727_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221321_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGCCACCCC

SOURCE GeneReport for Unigene cluster: Hs.97044
UniProtKB/Swiss-Prot: KCIP2_HUMAN, Q9NS61
Tissue specificity: Expressed in brain. Colocalizes with KCND2 in excitatory neurons including
cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical
vein endothelial cells. Not expressed in fetal heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNIP2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNIP2¹	--	Kv channel interacting protein 2	94.16(n) 97.67(a)	403598 XM_845759.1 XP_850852.1
chimpanzee (Pan troglodytes)	KCNIP2¹	--	Kv channel interacting protein 2	93.68(n) 92.28(a)	745263 XM_001170610.1 XP_001170610.1
cow (Bos taurus)	KCNIP2¹	--	Kv channel interacting protein 2	94.97(n) 98.95(a)	540895 XM_873691.2 XP_878784.1
rat (Rattus norvegicus)	Kchip2¹	--	A-type potassium channel modulatory protein 2	95.56(n) 98.52(a)	619380 NM_001034005.1 NP_001029177.1
mouse (Mus musculus)	Kcnip2⁵	19 (45.20 cM)	Kv channel-interacting protein 2	--	DQ148505

About this table Species with no ortholog for KCNIP2

ENSEMBL Gene Tree for KCNIP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNIP2 gene

EFCAB1² KCNIP3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/82 NCBI SNPs in KCNIP2 are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10883689^1,2	A,C,F,H	103576346(+)	`AGGAAG/AGAAGG`	6	--	ut3¹ trp³		10		EU EA WA NA	1018
	rs12572354^1,2	C,H	103593266(+)	`AGCCGT/ACCAGG`	6	V/D	mis¹ ese³		4		EU EA WA	414
	rs3209554^1,2	C,F	103576419(-)	`TTCCAC/AACCCT`	6	--	ut3¹ ese³		1		MN	184
--	rs17094373^1,2	F	103590507(+)	`CTCCTA/GACTCT`	7	--	int¹ ng3¹		3		NA	136
	rs2305190^1,2	H	103576871(-)	`CACCCC/GCTTCC`	6	--	ut3¹ ese³ trp³		5		EA EU WA	1914
--	rs11191128^1,2	C	103594209(+)	`CCATAA/GGCCGA`	6	--	ng3¹		0	--	--	--	--
	rs874885^1,2	A,C,F,H	103589315(-)	`CTTACA/TGAGCA`	7	--	int¹		8		EU EA WA NA	780
	rs1562364^1,2	A,C,F,H	103578724(-)	`AGGTGC/TGGGCG`	7	--	int¹		5		MN EU EA WA	596
	rs755381^1,2	A,C,F,H	103584886(-)	`ATACAA/GCACAT`	7	--	int¹		12		NA EA EU WA	2162
	rs2305189^1,2	A,C,F,H	103577542(-)	`TCTCTT/CTTGCC`	7	--	int¹ trp³		5		EA EU WA	1896

About this table

HapMap Linkage Disequilibrium images for KCNIP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604661

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/55 PubMed articles for KCNIP2 gene (see all 55 ):

Modulation of A-type potassium channels by a family of calcium sensors. (PubMed id 10676964)^{2, 3, 4} An W.F.... Rhodes K.J. (2000)
Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. (PubMed id 11263977)^{1, 3, 4} Ohya S....Imaizumi Y. (2001)
Modulation of Kv4.3 current by accessory subunits. (PubMed id 12297301)^{1, 3, 4} Deschenes I. and Tomaselli G.F. (2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. (PubMed id 14980201)^{3, 4} Kim L.A....Grigorieff N. (2004)
Protein-protein interactions of KChIP proteins and Kv4.2. (PubMed id 15358149)^{3, 4} Lin Y.-L.... Chang L.S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. (PubMed id 14623880)^{3, 4} Kim L.A.... Goldstein S.A. (2004)
KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. (PubMed id 15356203)^{3, 4} Rhodes K.J.... Trimmer J.S. (2004)
A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. (PubMed id 12829703)^{3, 4} Shibata R.... Trimmer J.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 30819	HGNC: 15522	AceView: KCNIP2	Ensembl:ENSG00000120049	euGenes: HUgn30819
ECgene: KCNIP2	H-InvDB: KCNIP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNIP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNIP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNIP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNIP2		Antibodies for KCNIP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNIP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KCNIP2)
	Search for Antibodies
	Chimera RNAi (KCNIP2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (KChIP2)
	Antibodies (KChIP2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for KCNIP2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KCNIP2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KCNIP2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

KCNIP2 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for KCNIP2

Summaries
for KCNIP2

Genomic Location
for KCNIP2

Proteins
for KCNIP2

Protein Domains/
Families
for KCNIP2

Gene Function
for KCNIP2

Pathways & Interactions
for KCNIP2

Drugs & Compounds
for KCNIP2

Transcripts
for KCNIP2

Expression
for KCNIP2

Orthologs
for KCNIP2

Paralogs
for KCNIP2

SNPs/Variants
for KCNIP2

Disorders & Mutations
for KCNIP2

Medical News
for KCNIP2

Publications
for KCNIP2

Search for KCNIP2

Genome Databases showing KCNIP2

Other Databases showing KCNIP2

Specialized Databases showing KCNIP2

Licensable Technologies
for KCNIP2

Services
for KCNIP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNIP2 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor KCNIP2

Summariesfor KCNIP2

Genomic Locationfor KCNIP2

Proteinsfor KCNIP2

Protein Domains/Familiesfor KCNIP2

Gene Functionfor KCNIP2

Pathways & Interactionsfor KCNIP2

Drugs & Compoundsfor KCNIP2

Transcriptsfor KCNIP2

Expression for KCNIP2

Orthologsfor KCNIP2

Paralogsfor KCNIP2

SNPs/Variantsfor KCNIP2

Disorders & Mutationsfor KCNIP2

Medical Newsfor KCNIP2

Publicationsfor KCNIP2

Search for KCNIP2

Genome Databases showing KCNIP2

Other Databases showing KCNIP2

Specialized Databases showing KCNIP2

Licensable Technologiesfor KCNIP2

Servicesfor KCNIP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNIP2

Summaries
for KCNIP2

Genomic Location
for KCNIP2

Proteins
for KCNIP2

Protein Domains/
Families
for KCNIP2

Gene Function
for KCNIP2

Pathways & Interactions
for KCNIP2

Drugs & Compounds
for KCNIP2

Transcripts
for KCNIP2

Expression
for KCNIP2

Orthologs
for KCNIP2

Paralogs
for KCNIP2

SNPs/Variants
for KCNIP2

Disorders & Mutations
for KCNIP2

Medical News
for KCNIP2

Publications
for KCNIP2

Licensable Technologies
for KCNIP2

Services
for KCNIP2