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Aliases for KCNIP2 Gene

Aliases for KCNIP2 Gene

  • Potassium Voltage-Gated Channel Interacting Protein 2 2 3
  • Cardiac Voltage-Gated Potassium Channel Modulatory Subunit 3 4
  • A-Type Potassium Channel Modulatory Protein 2 3 4
  • Potassium Channel-Interacting Protein 2 3 4
  • Kv Channel Interacting Protein 2 3 5
  • KCHIP2 3 4
  • Kv Channel-Interacting Protein 2 2

External Ids for KCNIP2 Gene

Previous GeneCards Identifiers for KCNIP2 Gene

  • GC10M102478
  • GC10M102819
  • GC10M103716
  • GC10M103250
  • GC10M103575
  • GC10M097216

Summaries for KCNIP2 Gene

Entrez Gene Summary for KCNIP2 Gene

  • This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNIP2 Gene

KCNIP2 (Potassium Voltage-Gated Channel Interacting Protein 2) is a Protein Coding gene. Diseases associated with KCNIP2 include Spinocerebellar Ataxia Type 19/22 and Brugada Syndrome. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Phase 1 - inactivation of fast Na+ channels. GO annotations related to this gene include calcium ion binding and protein N-terminus binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for KCNIP2 Gene

  • Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).

Tocris Summary for KCNIP2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNIP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNIP2 Gene

Genomics for KCNIP2 Gene

Regulatory Elements for KCNIP2 Gene

Enhancers for KCNIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNIP2 on UCSC Golden Path with GeneCards custom track

Promoters for KCNIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNIP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KCNIP2 gene promoter:

Genomic Location for KCNIP2 Gene

Chromosome:
10
Start:
101,825,974 bp from pter
End:
101,843,920 bp from pter
Size:
17,947 bases
Orientation:
Minus strand

Genomic View for KCNIP2 Gene

Genes around KCNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNIP2 Gene

Proteins for KCNIP2 Gene

  • Protein details for KCNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS61-KCIP2_HUMAN
    Recommended name:
    Kv channel-interacting protein 2
    Protein Accession:
    Q9NS61
    Secondary Accessions:
    • A6NJE5
    • A8MQ75
    • Q3YAC6
    • Q3YAC8
    • Q3YAC9
    • Q7Z6F1
    • Q96K86
    • Q96T41
    • Q96T42
    • Q96T43
    • Q96T44
    • Q9H0N4
    • Q9HD10
    • Q9HD11
    • Q9NS60
    • Q9NY10
    • Q9NZI1

    Protein attributes for KCNIP2 Gene

    Size:
    270 amino acids
    Molecular mass:
    30907 Da
    Quaternary structure:
    • Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits (PubMed:14623880, PubMed:14980201). Interacts with KCND2 (PubMed:10676964, PubMed:14623880, PubMed:14980201). Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner.

    Alternative splice isoforms for KCNIP2 Gene

neXtProt entry for KCNIP2 Gene

Proteomics data for KCNIP2 Gene at MOPED

Post-translational modifications for KCNIP2 Gene

  • Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNIP2 Gene

Domains & Families for KCNIP2 Gene

Protein Domains for KCNIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS61

UniProtKB/Swiss-Prot:

KCIP2_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with KCNIP2: view

Function for KCNIP2 Gene

Molecular function for KCNIP2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).

Gene Ontology (GO) - Molecular Function for KCNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,TAS 11287421
GO:0047485 protein N-terminus binding IPI 11287421
genes like me logo Genes that share ontologies with KCNIP2: view
genes like me logo Genes that share phenotypes with KCNIP2: view

Animal Models for KCNIP2 Gene

MGI Knock Outs for KCNIP2:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNIP2 Gene

Localization for KCNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNIP2 Gene

Isoform 1: Cell membrane; Lipid-anchor. Note=Detected on lipid rafts (By similarity). {ECO:0000250 UniProtKB:Q9JM59}.
Isoform 2: Cell membrane; Lipid-anchor.
Isoform 6: Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNIP2 Gene COMPARTMENTS Subcellular localization image for KCNIP2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNIP2: view

Pathways & Interactions for KCNIP2 Gene

genes like me logo Genes that share pathways with KCNIP2: view

Pathways by source for KCNIP2 Gene

Gene Ontology (GO) - Biological Process for KCNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005513 detection of calcium ion TAS 10676964
GO:0006813 potassium ion transport TAS 11287421
GO:0006936 muscle contraction NAS 11287421
GO:0007268 synaptic transmission NAS 11287421
GO:0008016 regulation of heart contraction TAS 11287421
genes like me logo Genes that share ontologies with KCNIP2: view

No data available for SIGNOR curated interactions for KCNIP2 Gene

Drugs & Compounds for KCNIP2 Gene

(3) Drugs for KCNIP2 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Potassium Experimental Pharma 0
calcium Nutra 0
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNIP2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNIP2 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNIP2: view

Transcripts for KCNIP2 Gene

Unigene Clusters for KCNIP2 Gene

Kv channel interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - - - - -
SP8: - -
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12:

Relevant External Links for KCNIP2 Gene

GeneLoc Exon Structure for
KCNIP2
ECgene alternative splicing isoforms for
KCNIP2

Expression for KCNIP2 Gene

mRNA expression in normal human tissues for KCNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNIP2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.5), Heart - Left Ventricle (x6.5), Brain - Putamen (basal ganglia) (x6.0), and Brain - Caudate (basal ganglia) (x5.1).

Protein differential expression in normal tissues from HIPED for KCNIP2 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNIP2 Gene



SOURCE GeneReport for Unigene cluster for KCNIP2 Gene Hs.97044

mRNA Expression by UniProt/SwissProt for KCNIP2 Gene

Q9NS61-KCIP2_HUMAN
Tissue specificity: Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
genes like me logo Genes that share expression patterns with KCNIP2: view

Protein tissue co-expression partners for KCNIP2 Gene

Primer Products

Orthologs for KCNIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KCNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KCNIP2 35
  • 94.32 (n)
  • 98.15 (a)
KCHIP2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnip2 35
  • 92.35 (n)
  • 96.67 (a)
Kcnip2 16
Kcnip2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNIP2 35
  • 99.74 (n)
  • 99.6 (a)
KCNIP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911951 35
  • 91.46 (n)
  • 95.44 (a)
cow
(Bos Taurus)
Mammalia KCNIP2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNIP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNIP2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNIP2 35
  • 83.73 (n)
  • 92.86 (a)
KCNIP2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNIP2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnip2 35
  • 78.31 (n)
  • 90.08 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003947 35
  • 67.59 (n)
  • 67.46 (a)
kcnip2 36
  • 63 (a)
OneToMany
KCNIP2 (1 of 2) 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5890 37
  • 49 (a)
CG42683 36
  • 16 (a)
ManyToMany
CG5890 36
  • 43 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ncs-4 36
  • 27 (a)
ManyToMany
ncs-7 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRQ1 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for KCNIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNIP2 Gene

ENSEMBL:
Gene Tree for KCNIP2 (if available)
TreeFam:
Gene Tree for KCNIP2 (if available)

Paralogs for KCNIP2 Gene

genes like me logo Genes that share paralogs with KCNIP2: view

Variants for KCNIP2 Gene

Sequence variations from dbSNP and Humsavar for KCNIP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3781298 -- 101,831,720(-) TATGC(A/C)TCCTG intron-variant
rs3781299 -- 101,830,837(-) GTGTG(G/T)GGGGG intron-variant
rs3837343 -- 101,830,769(-) TGTGT(-/GTGT/GTGTGT/GTGTGTGT)ATGGG intron-variant
rs4142930 -- 101,836,036(+) ATTGG(A/C)CCCAG intron-variant
rs755380 -- 101,835,314(+) TTTCA(A/C/G/T)TGCCT intron-variant

Variation tolerance for KCNIP2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KCNIP2 Gene

Disorders for KCNIP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KCNIP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia type 19/22
  • spinocerebellar ataxia 19/22
brugada syndrome
  • sudden unexpected nocturnal death syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KCNIP2

Genetic Association Database (GAD)
KCNIP2
Human Genome Epidemiology (HuGE) Navigator
KCNIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNIP2
genes like me logo Genes that share disorders with KCNIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNIP2 Gene

Publications for KCNIP2 Gene

  1. Modulation of A-type potassium channels by a family of calcium sensors. (PMID: 10676964) An W.F. … Rhodes K.J. (Nature 2000) 2 3 4 67
  2. [Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation]. (PMID: 19927631) Tan X.Q. … Zeng X.R. (Zhonghua Xin Xue Guan Bing Za Zhi 2009) 3 23
  3. Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells. (PMID: 18501111) Liu W.J. … Liu J. (Acta Pharmacol. Sin. 2008) 3 23
  4. Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. (PMID: 18585502) Landsberger M. … Felix S.B. (Am. Heart J. 2008) 3 23
  5. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PMID: 16112838) Pruunsild P. … Timmusk T. (Genomics 2005) 3 23

Products for KCNIP2 Gene

Sources for KCNIP2 Gene

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