KCNIP1 Gene

Aliases
for KCNIP1 gene

Previous GC identifers: GC05P170167 GC05P170634 GC05P169716 GC05P169911 GC05P169863 GC05P164879

Summaries
for KCNIP1 gene

Genomic Views
for KCNIP1 gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_023133.13  

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNIP1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNIP1

KCNIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P169780:  view genomic region     (about GC identifiers)

Proteins
for KCNIP1 gene

3 PDB 3D structures from and Proteopedia for KCNIP1:

1S1E (3D)        2I2R (3D)        2NZ0 (3D)    

Explore the universe of human proteins at neXtProt for KCNIP1: NX_Q9NZI2

KCNIP1 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: KCNIP1 OriGene Protein Over-expression Lysate: KCNIP1 OriGene Custom Protein Services for KCNIP1
	GenScript Custom Purified and Recombinant Proteins Services for KCNIP1
	Novus Biologicals KCNIP1 Protein Novus Biologicals KCNIP1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KCNIP1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: KCNIP1 OriGene Custom Antibody Services for KCNIP1
	GenScript Custom Superior Antibodies Services for KCNIP1
	Novus Biologicals KCNIP1 Antibodies
	Abcam antibodies for KCNIP1
	Uscn Antibodies for KCNIP1
	ThermoFisher Antibodies for KCNIP1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNIP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KCNIP1

Protein Domains /
Families
for KCNIP1 gene

ProtoNet protein and cluster: Q9NZI2

Function
for KCNIP1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): KCNIP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNIP1
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNIP1 (see all 29):
		hsa-miR-4291 hsa-miR-148b* hsa-miR-875-3p hsa-miR-495 hsa-miR-4251 hsa-miR-1260b hsa-miR-650 hsa-miR-3921
		SwitchGear 3'UTR luciferase reporter plasmid: KCNIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNIP1 (see all 7) OriGene shRNA RFP: KCNIP1 OriGene siRNA: KCNIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNIP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KCNIP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNIP1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNIP1 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): KCNIP1 (NM_014592)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNIP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNIP1
		Search LifeMap BioReagents cell lines for KCNIP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNIP1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

Pathways & Interactions
for KCNIP1 gene

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for KCNIP1 gene

Transcripts
for KCNIP1 gene

Expression
for KCNIP1 gene

KCNIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTAACCAA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerGABAergic Amacrine Cells			Amacrine, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ progenitor E68 (Embryonic Progenitor Cell)
	PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)			Intermediate Mesoderm, Kidney
	PureStem™ progenitor T42 (Embryonic Progenitor Cell)
	PureStem™ progenitor E69 (Embryonic Progenitor Cell)
	PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNIP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNIP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNIP1

Orthologs
for KCNIP1 gene

Paralogs
for KCNIP1 gene

Paralogs for KCNIP1 gene

HPCA²  KCNIP3²  KCNIP4²  GUCA1A²  RCVRN²  HPCAL1²  GUCA1B²  NCALD²  

KCNIP2²  HPCAL4²  NCS1²  VSNL1²  GUCA1C²  

17 SIMAP similar genes for KCNIP1 using alignment to 3 protein entries:     KCIP1_HUMAN (see all proteins):

KCNIP4    KCNIP3    KCNIP2    VSNL1    HPCA    NCALD

DKFZp781K1922    HPCAL1    NCS1    HPCAL4    RCV1    RCVRN

GUCA1C    GUCA1B    GUCA1A    DKFZp686E1183    PPP3R1

KCNIP1 for paralogs           About GeneDecksing

Genomic Variants
for KCNIP1 gene

10/6645 NCBI SNPs in KCNIP1 are shown (see all 6645)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1471476961,2	C,F,	other	175677059(+)	CTGTCG/AATTTT	6	/S	syn1		2		NA EU	5871
rs761310261,2	F,	--	164878223(+)	GCTTCG/AGGGTT	1	--	us2k1		1		NA	120
rs104759381,2	C,F,H,	--	164878636(+)	TTGTTT/CTGGGG	1	--	us2k1		5		NS EA WA	536
rs68788551,2	C,F,	--	164878695(+)	GGGTCC/TCTTCC	1	--	us2k1		2		WA NA	238
rs68788561,2	C,F,	--	164878696(+)	GGTCCC/GTTCCA	1	--	us2k1		2		WA NA	238
rs104755421,2	C,F,H,	--	164878849(+)	ATGACA/GTTTCT	1	--	us2k1		12		NS EA NA WA CSA	1210
rs1134059541,2		--	164879032(+)	GGCAGA/GCAGCA	1	--	us2k1		2		CSA WA	120
rs133403901,2	C,F,H,	--	164879116(+)	TCCCCG/AGAGGC	1	--	us2k1		6		NS EA CSA WA	533
rs793493821,2	C,F,	--	164879280(+)	AGGAAG/AGAAAG	1	--	us2k1		1		WA	118
rs1132555871,2		--	164879439(+)	CCCTGC/TTCTGC	1	--	us2k1		1		CSA	2

HapMap Linkage Disequilibrium report for KCNIP1 (169780491 - 170030491 bp, first 250kb of KCNIP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 20 variations for KCNIP1
     8 CNVs: 81117 93351 81120 64366 43386 99351 81118 93349
     12 Indels: 81119 93354 93356 93350 93353 81122 41284 42234 81123 93355 81121 93352

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNIP1

DNA2.0 Custom Variant and Variant Library Synthesis for KCNIP1

Disorders / Diseases
for KCNIP1 gene

Publications
for KCNIP1 gene

PubMed articles for KCNIP1 gene, integrated from 9 sources (see all 33): (articles sorted by number of sources associating them with KCNIP1)

Utopia: connect your pdf to the dynamic world of online information

1. Modulation of A-type potassium channels by a family of calcium sensors. (PubMed id 10676964)^{1, 2, 3} An W.F.... Rhodes K.J. (2000)
2. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. (PubMed id 14980207)^{1, 2, 9} Scannevin R.H.... Rhodes K.J. (2004)
3. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. (PubMed id 11423117)^{1, 2, 9} Nakamura T.Y....Coetzee W.A. (2001)
4. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PubMed id 16112838)^{1, 2, 9} Pruunsild P. and Timmusk T. (2005)
5. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. (PubMed id 17057713)^{1, 2} Pioletti M.... Minor D.L. Jr. (2006)
6. Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. (PubMed id 15184042)^{1, 2} Lin Y.-L.... Chang L.-S. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. Protein-protein interactions of KChIP proteins and Kv4.2. (PubMed id 15358149)^{1, 2} Lin Y.-L.... Chang L.S. (2004)
9. Differential modulation of Kv4 kinetics by KCHIP1 splice variants. (PubMed id 14572458)^{1, 2} Van Hoorick D.... Snyders D.J. (2003)
10. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. (PubMed id 12829703)^{1, 2} Shibata R.... Trimmer J.S. (2003)

External Searches for KCNIP1 gene

Genome Databases showing KCNIP1 gene

Other Databases showing KCNIP1 gene

Specialized Databases showing KCNIP1 gene

Products
for KCNIP1 gene