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Aliases for KCNIP1 Gene

Aliases for KCNIP1 Gene

  • Kv Channel Interacting Protein 1 2 3
  • A-Type Potassium Channel Modulatory Protein 1 3 4
  • Vesicle APC-Binding Protein 3 4
  • KCHIP1 3 4
  • VABP 3 4
  • Potassium Channel Interacting Protein 1 3
  • Potassium Channel-Interacting Protein 1 4
  • Kv Channel-Interacting Protein 1 3

External Ids for KCNIP1 Gene

Previous GeneCards Identifiers for KCNIP1 Gene

  • GC05P170167
  • GC05P170634
  • GC05P169716
  • GC05P169911
  • GC05P169863
  • GC05P164879
  • GC05P169780

Summaries for KCNIP1 Gene

Entrez Gene Summary for KCNIP1 Gene

  • This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for KCNIP1 Gene

KCNIP1 (Kv Channel Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein N-terminus binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for KCNIP1 Gene

  • Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.

Tocris Summary for KCNIP1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNIP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNIP1 Gene

Genomics for KCNIP1 Gene

Regulatory Elements for KCNIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNIP1 Gene

170,353,487 bp from pter
170,736,632 bp from pter
383,146 bases
Plus strand

Genomic View for KCNIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNIP1 Gene

Proteins for KCNIP1 Gene

  • Protein details for KCNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kv channel-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z7B4
    • Q3YAD0
    • Q3YAD1
    • Q3YAD2
    • Q3YAD3
    • Q5U822

    Protein attributes for KCNIP1 Gene

    227 amino acids
    Molecular mass:
    26817 Da
    Quaternary structure:
    • Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3.

    Three dimensional structures from OCA and Proteopedia for KCNIP1 Gene

    Alternative splice isoforms for KCNIP1 Gene


neXtProt entry for KCNIP1 Gene

Proteomics data for KCNIP1 Gene at MOPED

Post-translational modifications for KCNIP1 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for KCNIP1 Gene

Domains for KCNIP1 Gene

Gene Families for KCNIP1 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for KCNIP1 Gene

Suggested Antigen Peptide Sequences for KCNIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NZI2
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with KCNIP1: view

Function for KCNIP1 Gene

Molecular function for KCNIP1 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.

Gene Ontology (GO) - Molecular Function for KCNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0005509 calcium ion binding IDA 17187064
GO:0005515 protein binding IPI 15358149
GO:0015459 potassium channel regulator activity IDA 10676964
genes like me logo Genes that share ontologies with KCNIP1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNIP1 Gene

Localization for KCNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNIP1 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, dendrite.

Subcellular locations from

Jensen Localization Image for KCNIP1 Gene COMPARTMENTS Subcellular localization image for KCNIP1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix --
GO:0005737 cytoplasm IDA 10676964
GO:0005886 plasma membrane --
GO:0008076 voltage-gated potassium channel complex IDA 10676964
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with KCNIP1: view

Pathways for KCNIP1 Gene

SuperPathways for KCNIP1 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for KCNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005513 detection of calcium ion --
GO:0007165 signal transduction --
GO:0007268 synaptic transmission --
GO:0034765 regulation of ion transmembrane transport --
GO:0045760 positive regulation of action potential IEA --
genes like me logo Genes that share ontologies with KCNIP1: view

No data available for Pathways by source for KCNIP1 Gene

Compounds for KCNIP1 Gene

(5) Tocris Compounds for KCNIP1 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(2) HMDB Compounds for KCNIP1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • K+

(2) Novoseek inferred chemical compound relationships for KCNIP1 Gene

Compound -log(P) Hits PubMed IDs
potassium 37.1 1
calcium 13.9 2

(1) PharmGKB related drug/compound annotations for KCNIP1 Gene

Drug/compound Annotation
verapamil CA
genes like me logo Genes that share compounds with KCNIP1: view

Transcripts for KCNIP1 Gene

Unigene Clusters for KCNIP1 Gene

Kv channel interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNIP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for KCNIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNIP1 Gene

mRNA expression in normal human tissues for KCNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNIP1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.4), Brain - Putamen (basal ganglia) (5.2), Brain - Amygdala (5.0), Brain - Hypothalamus (5.0), Brain - Caudate (basal ganglia) (4.9), and Brain - Anterior cingulate cortex (BA24) (4.1).

Protein differential expression in normal tissues for KCNIP1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNIP1 Gene

SOURCE GeneReport for Unigene cluster for KCNIP1 Gene Hs.484111

mRNA Expression by UniProt/SwissProt for KCNIP1 Gene

Tissue specificity: Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus
genes like me logo Genes that share expressions with KCNIP1: view

Expression partners for KCNIP1 Gene

In Situ Assay Products

Orthologs for KCNIP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KCNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNIP1 35
  • 94.29 (n)
  • 98.15 (a)
  • 98 (a)
(Canis familiaris)
Mammalia KCNIP1 35
  • 91.92 (n)
  • 94.71 (a)
  • 91 (a)
(Mus musculus)
Mammalia Kcnip1 35
  • 91.92 (n)
  • 99.56 (a)
Kcnip1 16
Kcnip1 36
  • 100 (a)
(Pan troglodytes)
Mammalia KCNIP1 35
  • 99.41 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Kcnip1 35
  • 91.78 (n)
  • 99.12 (a)
(Monodelphis domestica)
Mammalia KCNIP1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia KCNIP1 36
  • 94 (a)
(Gallus gallus)
Aves KCNIP1 35
  • 79.44 (n)
  • 93.39 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia KCNIP1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnip1 35
  • 75.77 (n)
  • 88.55 (a)
(Danio rerio)
Actinopterygii kcnip1a 35
  • 77.04 (n)
  • 83.16 (a)
kcnip1a 36
  • 76 (a)
kcnip1b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5890 37
  • 51 (a)
CG5890 35
  • 57.85 (n)
  • 53.44 (a)
CG42683 36
  • 15 (a)
CG5890 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002000 35
  • 59.7 (n)
  • 53.11 (a)
(Caenorhabditis elegans)
Secernentea F21A10.1 37
  • 34 (a)
ncs-3 36
  • 41 (a)
ncs-4 36
  • 29 (a)
ncs-7 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRQ1 36
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13134 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for KCNIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNIP1 Gene

Gene Tree for KCNIP1 (if available)
Gene Tree for KCNIP1 (if available)

Paralogs for KCNIP1 Gene

Selected SIMAP similar genes for KCNIP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNIP1: view

Variants for KCNIP1 Gene

Sequence variations from dbSNP and Humsavar for KCNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs50057 -- 170,707,494(+) CACAC(A/G)AACAG intron-variant
rs50364 -- 170,710,705(+) TATCC(A/G)GTTGT intron-variant
rs102684 -- 170,708,153(+) CTTTC(C/T)GTCCC intron-variant
rs102685 -- 170,708,188(+) ACCAA(C/T)GTGGA intron-variant
rs102686 -- 170,708,221(+) GGAAC(A/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv462515 CNV Loss 19166990
nsv471054 CNV Loss 18288195
nsv883106 CNV Loss 21882294
esv2731063 CNV Deletion 23290073
esv2731064 CNV Deletion 23290073
esv2731065 CNV Deletion 23290073
esv2731066 CNV Deletion 23290073
esv2731067 CNV Deletion 23290073
esv2731068 CNV Deletion 23290073
nsv525397 CNV Loss 19592680
esv2656865 CNV Deletion 23128226
nsv5126 CNV Insertion 18451855
nsv5127 CNV Loss 18451855
esv2731069 CNV Deletion 23290073
esv2731070 CNV Deletion 23290073
esv3236 CNV Deletion 18987735
esv2731071 CNV Deletion 23290073
esv2731072 CNV Deletion 23290073
nsv462516 CNV Loss 19166990
esv2662417 CNV Deletion 23128226
nsv830549 CNV Gain 17160897
nsv462518 CNV Loss 19166990
esv2731074 CNV Deletion 23290073
esv2188655 CNV Deletion 18987734
esv2731075 CNV Deletion 23290073
esv2731076 CNV Deletion 23290073
esv2731077 CNV Deletion 23290073
nsv5128 CNV Insertion 18451855
esv2668484 CNV Deletion 23128226
esv2502584 CNV Deletion 19546169
nsv823343 CNV Loss 20364138
dgv154e180 CNV Gain 20482838
esv3889 CNV Deletion 18987735
dgv1056e199 CNV Deletion 23128226
esv22848 CNV Gain+Loss 19812545
nsv820522 CNV Deletion 20802225
esv2731078 CNV Deletion 23290073
nsv823344 CNV Loss 20364138
nsv823345 CNV Gain+Loss 20364138
nsv823346 CNV Loss 20364138
esv2731079 CNV Deletion 23290073
esv2666800 CNV Deletion 23128226
nsv510005 CNV Loss 20534489
esv2731080 CNV Deletion 23290073
esv2096299 CNV Deletion 18987734
esv4823 CNV Deletion 18987735
esv2731081 CNV Deletion 23290073
esv2521487 CNV Deletion 19546169
nsv330149 CNV Loss 16902084
esv1660639 CNV Deletion 17803354
esv2731082 CNV Deletion 23290073

Relevant External Links for KCNIP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNIP1 Gene

Disorders for KCNIP1 Gene

Relevant External Links for KCNIP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KCNIP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCNIP1 Gene

Publications for KCNIP1 Gene

  1. Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. (PMID: 11423117) Nakamura T.Y. … Coetzee W.A. (FEBS Lett. 2001) 3 4 23
  2. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. (PMID: 14980207) Scannevin R.H. … Rhodes K.J. (Neuron 2004) 3 4 23
  3. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. (PMID: 16112838) Pruunsild P. … Timmusk T. (Genomics 2005) 3 4 23
  4. Modulation of A-type potassium channels by a family of calcium sensors. (PMID: 10676964) An W.F. … Rhodes K.J. (Nature 2000) 2 3 4
  5. Functional interaction between KChIP1 and GFP-fused Kv4.3L co-expressed in HEK293 cells. (PMID: 11976919) Hatano N. … Imaizumi Y. (Pflugers Arch. 2002) 3 23

Products for KCNIP1 Gene

Sources for KCNIP1 Gene

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