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Aliases & Descriptions for KCNH8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ELK 2 | | ELK1 2, 3 | | ELK3 3 | | Kv12.1 1, 2 | | elk3 1, 2 | | hElk1 3 |
| | | Descriptions |
|---|
| ELK channel 3 3 | | Ether-a-go-go-like potassium channel 3 2, 3 | | Voltage-gated potassium channel subunit Kv12.1 3 | | ether-a-go-go-like potassium channel 1 2 | potassium voltage-gated channel, subfamily H (eag-related), member 8 2 | | potassium voltage-gated channel, subfamily H, member 8 2 |
|
| | Search outside databases for aliases for KCNH8 genePrevious GC identifers: GC03P018574 GC03P018804 GC03P019040 |
Summaries for KCNH8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNH8: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNH8_HUMAN, Q96L42Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly |
Genomic Location for KCNH8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNH8 gene 
Entrez Gene cytogenetic band: 3p24.3 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24.3KCNH8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P019165:
(about GC identifiers)
Start:
|
19,165,021 bp from pter |
End:
|
19,552,139 bp from pter |
Size:
|
387,119 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for KCNH8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNH8_HUMAN, Q96L42 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily H member 8 Size: 1107 amino acids; 123804 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q59GQ6REFSEQ proteins: NP_653234.2
ENSEMBL proteins: ENSP00000328813
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for KCNH8: Assays for KCNH8: | Protein
Domains/ Families for KCNH8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96L42
ProtoNet protein and cluster: Q96L42 5/6 Blocks protein families (see all 6
): IPB000014 PAS domain IPB000595 Cyclic nucleotide-binding domain IPB001610 PAC motif IPB003938 EAG/ELK/ERG potassium channel family signature IPB003950 ELK potassium channel family signature
UniProtKB/Swiss-Prot: KCNH8_HUMAN, Q96L42Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. H (Eag) subfamilySimilarity: Contains 1 cyclic nucleotide-binding domainSimilarity: Contains 1 PAC (PAS-associated C-terminal) domainSimilarity: Contains 1 PAS (PER-ARNT-SIM) domain | Gene Function for KCNH8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144633
Applied Biosystems Silencer® siRNAs for KCNH8
Sigma-Aldrich siRNA and siRNA Panels for KCNH8  Sigma-Aldrich shRNA Panels and shRNA for KCNH8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_144633                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_144633                                  untagged cDNA clone in CMV expression vector: NM_144633 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_144633
UniProtKB/Swiss-Prot: KCNH8_HUMAN, Q96L42Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000155 | two-component sensor activity |
IEA | -- | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNH8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNH8 
5/10 Interacting proteins for KCNH8 (ENSP000003288133) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000160 | two-component signal transduction system (phosphorelay) |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
IEA | -- | About this table
|
Drugs & Compounds for KCNH8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for KCNH8 |
Compounds for KCNH8 available from Tocris Bioscience About this table
1 Novoseek chemical compound relationship for KCNH8 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| potassium |
32.84 |
1 |
12890647 (1) |
About this table
|
Transcripts for KCNH8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_144633
Sigma-Aldrich siRNA and siRNA Panels for KCNH8  Sigma-Aldrich shRNA Panels and shRNA for KCNH8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_144633 REFSEQ mRNAs for KCNH8 gene: NM_144633.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_144633               OriGene GFP tagged cDNA clone in CMV expression vector: NM_144633                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_144633                                  untagged cDNA clone in CMV expression vector: NM_144633  Additional cDNA sequence: AB209053.1 AK294417.1 AK294759.1 AK295633.1 AK309034.1 AY053503.1 5 DOTS entries: DT.426005 DT.120856306 DT.75168344 DT.95219980 DT.92011108 9 AceView cDNA sequences:BX095864 AI187878 BC031226 BE244277 NM_144633 AY053503 CD637042 CD637044 N55423
highest scoring ESTs for KCNH8:AI187878 AY053503 BX095864 N55423 AA974031 AB209053 AL707308 AL708181 BC031226 BE244277 Unigene Cluster for KCNH8: Potassium voltage-gated channel, subfamily H (eag-related), member 8 Hs.475656 [show with all ESTs]Unigene Representative Sequence: AY053503
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH8
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KCNH8
1 Ensembl transcript including schematic representation: ENST00000328405
|
Expression for KCNH8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNH8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNH8
1 / 2 / 3 1 probe-set matching KCNH8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTTAAGGTC
SOURCE GeneReport for Unigene cluster: Hs.475656 UniProtKB/Swiss-Prot: KCNH8_HUMAN, Q96L42Tissue specificity: Primarily expressed in the nervous system |
Orthologs for KCNH8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNH8 gene from 5/8 species (see all 8
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNH81 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
92.32(n) 95.93(a) |
485649 XM_542769.2 XP_542769.2 |
chimpanzee (Pan troglodytes) |
KCNH81 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
99.52(n) 99.19(a) |
460215 XM_001162632.1 XP_001162632.1 |
rat (Rattus norvegicus) |
Kcnh81 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
86.71(n) 92.64(a) |
246325 NM_145095.1 NP_659563.1 |
mouse (Mus musculus) |
Kcnh81, 5 |
175
|
potassium voltage-gated channel, subfamily H (eag-related), more1, 5 |
86.92(n)1 92.55(a)1 |
2114681 NM_001031811.11 NP_001026981.11 AC1220555 AC1225405 (see all 13) |
chicken (Gallus gallus) |
KCNH81 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
78.96(n) 84.27(a) |
420648 XM_418747.2 XP_418747.2 |
About this table Species with no ortholog for KCNH8
ENSEMBL Gene Tree for KCNH8 | Paralogs for KCNH8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNH8 gene
- KCNH42 KCNH32
|
SNPs/Variants for KCNH8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNH8 (up to first 250kb)
|
Disorders & Mutations for KCNH8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608260
|
Medical News for KCNH8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNH8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for KCNH8 gene: |
Search for KCNH8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNH8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNH8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNH8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNH8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNH8:

 | |
 | | | | |
|
 |  |  |
| | | | Tocris compounds for KCNH8 |
|
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Incremental update: 13 Oct 2009
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