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Aliases & Descriptions for KCNH7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ERG3 2 , 3 , 5 HERG-3 3 HERG3 1 , 2 , 5 Kv11.3 1 , 2 , 5 MGC45986 2 erg3 1
Descriptions Eag-related protein 3 3 Ether-a-go-go-related gene potassium channel 3 3 Ether-a-go-go-related protein 3 3 Voltage-gated potassium channel subunit Kv11.3 3 eag related protein 3 2 ether-a-go-go related gene potassium channel 3 2 potassium channel subunit HERG-3 2 potassium voltage-gated channel, subfamily H (eag-related), member 7 2 potassium voltage-gated channel, subfamily H, member 7 2
Search outside databases for aliases for KCNH7 genePrevious GC identifers: GC02M161281 GC02M161756 GC02M163191 GC02M163430 GC02M163053
Summaries for KCNH7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for KCNH7 : Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ionchannels from both functional and structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes amember of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha)subunit. There are at least two alternatively spliced transcript variants derived from this geneand encoding distinct isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 Function : Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties maybe modulated by cAMP and subunit assembly
Genomic Location for KCNH7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the KCNH7 gene Entrez Gene cytogenetic band: 2q24.2 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24.3 KCNH7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M162936:
(about GC identifiers )
Start:
162,936,163 bp from pter
End:
163,403,486 bp from pter
Size:
467,324 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_005403.16 Proteins for KCNH7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 (See
protein sequence )Recommended Name: Potassium voltage-gated channel subfamily H member 7 Size : 1196 amino acids; 135000 Da
Subunit : The potassium channel is probably composed of a homo- or heterotetrameric complex ofpore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer withKCNH2/ERG1 and KCNH6/ERG2 (By similarity)
Subcellular location : Membrane; Multi-pass membrane protein
Sequence caution : Sequence=AAD01946.1; Type=Frameshift; Positions=792, 795;
Secondary accessions : Q53QU4 Q53TB7 Q53TP9 Q8IV15Alternative splicing : 2 isoforms : Q9NS40-1 Q9NS40-2
REFSEQ proteins (2 alternative transcripts):
NP_150375.2 NP_775185.1 ENSEMBL proteins: ENSP00000331727 ENSP00000376488 ENSP00000333781 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for KCNH7: Assays for KCNH7:
Protein
Domains/ Families for KCNH7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NS40 ProtoNet protein and cluster: Q9NS40
5 Blocks protein families : IPB000014 PAS domain IPB000595 Cyclic nucleotide-binding domain IPB001610 PAC motif IPB003938 EAG/ELK/ERG potassium channel family signature IPB003967 ERG potassium channel family signature UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 Domain : The segment S4 is probably the voltage-sensor and is characterized by a series ofpositively charged amino acids at every third position Similarity : Belongs to the potassium channel family. H (Eag) subfamilySimilarity : Contains 1 cyclic nucleotide-binding domainSimilarity : Contains 1 PAC (PAS-associated C-terminal) domainSimilarity : Contains 1 PAS (PER-ARNT-SIM) domain
Gene Function for KCNH7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_173162 Applied Biosystems Silencer ® siRNAs for KCNH7 Sigma-Aldrich siRNA and siRNA Panels for KCNH7 Sigma-Aldrich shRNA Panels and shRNA for KCNH7 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_033272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_033272                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_033272  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033272 UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 Function : Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties maybe modulated by cAMP and subunit assembly
1 MGI phenotypic allele for Kcnh7 (no phenotypes)5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for KCNH7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Interacting proteins for KCNH7 (ENSP00000331727 3 Q9NS40 1 ) via UniProtKB, MINT, and/or STRING About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006811 ion transport
IEA -- GO:0006813 potassium ion transport
IEA -- GO:0007165 signal transduction
IEA --
About this table
Drugs & Compounds for KCNH7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for KCNH7 available from Tocris Bioscience About this table
Transcripts for KCNH7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_173162 Sigma-Aldrich siRNA and siRNA Panels for KCNH7 Sigma-Aldrich shRNA Panels and shRNA for KCNH7 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_033272 NM_173162
REFSEQ mRNAs for KCNH7 gene (2 alternative transcripts): NM_033272.2 NM_173162.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033272 NM_173162
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_033272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_033272                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_033272  
Additional cDNA sequence: AF032897.1 AK098545.1 BC035815.1
4 DOTS entries : DT.40110642 DT.75112197 DT.40120858 DT.102834918
24/35 AceView cDNA sequences (see all 35
):NM_173162 CD634938 CD634945 BC035815 CD634935 AK098545 AA496138 CD634932 NM_033272 AF032897 CD634943 CD634930 CD634941 CD634936 BG200964 AA496139 CD634953 CD634939 BG617817 CD634928 U48352 CD634933 CD634952 CD634951
highest scoring ESTs for KCNH7 :AF032897 BC035815 BM928062 AA496138 AK098545 BG617817 CD634928 CD634929 CD634930 CD634932
Unigene Cluster for KCNH7: Potassium voltage-gated channel, subfamily H (eag-related), member 7 Hs.657413 [show with all ESTs ] Unigene Representative Sequence: NM_033272 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH7 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 SP1 :       -   -       -         SP2 :                      
About this scheme ECgene alternative splicing isoforms for KCNH7 3 Ensembl transcripts including schematic representations : ENST00000332142
ENST00000392728
ENST00000328032
Expression for KCNH7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KCNH7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KCNH7 1 / 2 / 3
3 probe-sets matching KCNH7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTATGTATGTSOURCE GeneReport for Unigene cluster: Hs.657413 UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 Tissue specificity : Expressed in prolactin-secreting adenomas
Orthologs for KCNH7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KCNH7 gene from 5/9 species (see all 9
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
KCNH71
--
potassium voltage-gated channel, subfamily H (eag-related), more
93.34(n) 95.82(a)
478768 XM_535934.2 XP_535934.2
chimpanzee (Pan troglodytes)
KCNH71
--
potassium voltage-gated channel, subfamily H (eag-related), more
99.72(n) 99.83(a)
470573 XM_525954.2 XP_525954.2
cow (Bos taurus)
KCNH71
--
potassium voltage-gated channel, subfamily H (eag-related), more
92.77(n) 95.05(a)
534542 XM_614343.3 XP_614343.3
rat (Rattus norvegicus)
Kcnh71
--
potassium voltage-gated channel, subfamily H (eag-related), more
88.83(n) 94.71(a)
170739 NM_131912.1 NP_571987.1
mouse (Mus musculus)
Kcnh71 , 5
25
potassium voltage-gated channel, subfamily H (eag-related), more 1, 5
88.92(n) 1 94.79(a) 1
170738 1 NM_133207.2 1 NP_573470.2 1 AJ291608 5 AK034003 5 (see all 11 )
About this table Species with no ortholog for KCNH7 ENSEMBL Gene Tree for KCNH7 Paralogs for KCNH7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KCNH7 gene KCNH6 2 KCNH2 2
SNPs/Variants for KCNH7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for KCNH7 (up to first 250kb)
Disorders & Mutations for KCNH7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608169 Human Genome Epidemiology Navigator: KCNH7 (2 documents)
Medical News for KCNH7 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KCNH7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for KCNH7 gene (see all 16
):
Search for KCNH7
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KCNH7
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KCNH7
(According to HUGE )
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--
Specialized Databases showing KCNH7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KCNH7 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for KCNH7:
Tocris compounds for KCNH7
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