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Aliases for KCNH7 Gene

Aliases for KCNH7 Gene

  • Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 7 2 3
  • ERG3 3 4 6
  • Ether-A-Go-Go-Related Gene Potassium Channel 3 3 4
  • Voltage-Gated Potassium Channel Subunit Kv11.3 3 4
  • Ether-A-Go-Go-Related Protein 3 3 4
  • Eag-Related Protein 3 3 4
  • Kv11.3 3 6
  • Erg-3 3 4
  • HERG3 3 6
  • Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 7 2
  • Potassium Voltage-Gated Channel Subfamily H Member 7 3
  • Potassium Channel Subunit HERG-3 3
  • HERG-3 4

External Ids for KCNH7 Gene

Previous GeneCards Identifiers for KCNH7 Gene

  • GC02M161281
  • GC02M161756
  • GC02M163191
  • GC02M163430
  • GC02M163053
  • GC02M162936
  • GC02M155110

Summaries for KCNH7 Gene

Entrez Gene Summary for KCNH7 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNH7 Gene

KCNH7 (Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 7) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include signal transducer activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for KCNH7 Gene

  • Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly

Tocris Summary for KCNH7 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNH7 Gene

Genomics for KCNH7 Gene

Regulatory Elements for KCNH7 Gene

Genomic Location for KCNH7 Gene

Start:
162,371,407 bp from pter
End:
162,838,747 bp from pter
Size:
467,341 bases
Orientation:
Minus strand

Genomic View for KCNH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNH7 Gene

Proteins for KCNH7 Gene

  • Protein details for KCNH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS40-KCNH7_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily H member 7
    Protein Accession:
    Q9NS40
    Secondary Accessions:
    • Q53QU4
    • Q53TB7
    • Q53TP9
    • Q8IV15

    Protein attributes for KCNH7 Gene

    Size:
    1196 amino acids
    Molecular mass:
    135000 Da
    Quaternary structure:
    • The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity).
    SequenceCaution:
    • Sequence=AAD01946.1; Type=Frameshift; Positions=792, 795; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNH7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNH7 Gene

Proteomics data for KCNH7 Gene at MOPED

Post-translational modifications for KCNH7 Gene

  • Glycosylation at Asn600
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNH7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNH7 Gene

Domains for KCNH7 Gene

Gene Families for KCNH7 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS40

UniProtKB/Swiss-Prot:

KCNH7_HUMAN :
  • Q9NS40
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • Contains 1 cyclic nucleotide-binding domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
Family:
  • Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily.
genes like me logo Genes that share domains with KCNH7: view

Function for KCNH7 Gene

Molecular function for KCNH7 Gene

UniProtKB/Swiss-Prot Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly

Gene Ontology (GO) - Molecular Function for KCNH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005216 ion channel activity --
GO:0005242 inward rectifier potassium channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005267 potassium channel activity --
genes like me logo Genes that share ontologies with KCNH7: view

Phenotypes for KCNH7 Gene

GenomeRNAi human phenotypes for KCNH7:
genes like me logo Genes that share phenotypes with KCNH7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNH7 Gene

Localization for KCNH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNH7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNH7 Gene COMPARTMENTS Subcellular localization image for KCNH7 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KCNH7: view

Pathways for KCNH7 Gene

genes like me logo Genes that share pathways with KCNH7: view

Pathways by source for KCNH7 Gene

1 Qiagen pathway for KCNH7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KCNH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006811 ion transport --
GO:0006813 potassium ion transport --
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with KCNH7: view

Compounds for KCNH7 Gene

(5) Tocris Compounds for KCNH7 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(1) HMDB Compounds for KCNH7 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(5) Drugbank Compounds for KCNH7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Doxazosin
  • Doxazosin mesilate
74191-85-8 target inhibitor
Ibutilide
  • Ibutilida [INN-Spanish]
122647-32-9 target inhibitor
Miconazole
22916-47-8 target inhibitor
Prazosin
  • Prazocin
19216-56-9 target inhibitor
Terazosin
  • Abbott 45975
63590-64-7 target inhibitor
genes like me logo Genes that share compounds with KCNH7: view

Transcripts for KCNH7 Gene

Unigene Clusters for KCNH7 Gene

Potassium voltage-gated channel, subfamily H (eag-related), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNH7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCNH7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNH7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2:

Relevant External Links for KCNH7 Gene

GeneLoc Exon Structure for
KCNH7
ECgene alternative splicing isoforms for
KCNH7

Expression for KCNH7 Gene

mRNA expression in normal human tissues for KCNH7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNH7 Gene

This gene is overexpressed in Whole Blood (19.4) and Testis (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNH7 Gene

SOURCE GeneReport for Unigene cluster for KCNH7 Gene Hs.657413

mRNA Expression by UniProt/SwissProt for KCNH7 Gene

Q9NS40-KCNH7_HUMAN
Tissue specificity: Expressed in prolactin-secreting adenomas.
genes like me logo Genes that share expressions with KCNH7: view

In Situ Assay Products

Orthologs for KCNH7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KCNH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNH7 35
  • 99.72 (n)
  • 99.83 (a)
KCNH7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNH7 36
  • 94 (a)
OneToOne
LOC534542 35
  • 92.86 (n)
  • 95.4 (a)
dog
(Canis familiaris)
Mammalia KCNH7 35
  • 93.34 (n)
  • 95.82 (a)
KCNH7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnh7 35
  • 88.92 (n)
  • 94.79 (a)
Kcnh7 16
Kcnh7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNH7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNH7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnh7 35
  • 88.83 (n)
  • 94.71 (a)
chicken
(Gallus gallus)
Aves KCNH7 35
  • 80.38 (n)
  • 86.87 (a)
KCNH7 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNH7 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnh7 35
  • 74.24 (n)
  • 80.53 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnh1a 36
  • 34 (a)
ManyToMany
si:dkey-240h6.1 35
  • 66.7 (n)
  • 71.7 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007709 35
  • 61.86 (n)
  • 66.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta sei 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-103 35
  • 58.59 (n)
  • 61.57 (a)
unc-103 36
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons KAT1 35
  • 41.06 (n)
  • 27.15 (a)
rice
(Oryza sativa)
Liliopsida Os02g0245800 35
  • 41.35 (n)
  • 27.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12709 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for KCNH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNH7 Gene

ENSEMBL:
Gene Tree for KCNH7 (if available)
TreeFam:
Gene Tree for KCNH7 (if available)

Paralogs for KCNH7 Gene

Selected SIMAP similar genes for KCNH7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNH7: view

Variants for KCNH7 Gene

Sequence variations from dbSNP and Humsavar for KCNH7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs305665 -- 162,807,350(-) AAGTG(A/T)TTCTC intron-variant
rs305666 -- 162,805,930(-) ttgcc(A/G)taaaa intron-variant
rs305667 -- 162,804,648(-) caata(C/T)tgatt intron-variant
rs305668 -- 162,804,621(-) atggg(A/T)tgtgt intron-variant
rs305669 -- 162,803,727(-) TACTG(C/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNH7 Gene

Variant ID Type Subtype PubMed ID
dgv4353n71 CNV Loss 21882294
nsv875354 CNV Loss 21882294
esv1006625 CNV Deletion 20482838
nsv875357 CNV Loss 21882294
nsv3011 CNV Insertion 18451855
esv2596964 CNV Deletion 19546169
nsv875358 CNV Gain 21882294
esv2667624 CNV Deletion 23128226
esv270053 CNV Insertion 20981092
esv273848 CNV Insertion 20981092
esv2130433 CNV Deletion 18987734
esv2721052 CNV Deletion 23290073
esv274108 CNV Insertion 20981092
esv2044759 CNV Deletion 18987734
esv2721053 CNV Deletion 23290073
esv3985 CNV Deletion 18987735
nsv214757 CNV Loss 16902084
esv9501 CNV Loss 19470904
esv2558699 CNV Insertion 19546169
esv273010 CNV Insertion 20981092
esv270107 CNV Insertion 20981092
nsv213705 CNV Insertion 16902084

Relevant External Links for KCNH7 Gene

HapMap Linkage Disequilibrium report
KCNH7
Human Gene Mutation Database (HGMD)
KCNH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNH7 Gene

Disorders for KCNH7 Gene

Relevant External Links for KCNH7

Genetic Association Database (GAD)
KCNH7
Human Genome Epidemiology (HuGE) Navigator
KCNH7
genes like me logo Genes that share disorders with KCNH7: view

No data available for UniProtKB/Swiss-Prot for KCNH7 Gene

Publications for KCNH7 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. (PMID: 20953190) . … Trembath R.C. (Nat. Genet. 2010) 3 48
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48
  5. HERG K(+) currents in human prolactin-secreting adenoma cells. (PMID: 12634931) Bauer C.K. … Schwarz J.R. (Pflugers Arch. 2003) 3 4

Products for KCNH7 Gene

Sources for KCNH7 Gene

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