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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNH7 Gene

protein-coding   GIFtS: 61
GCID: GC02M163191

potassium voltage-gated channel, subfamily H (eag-related),...
 Explore 5 diseases affiliated with
KCNH7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNH7    

Aliases
for KCNH7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 71 2     ERG-32 3
HERG31 2 5     Erg31
Kv11.31 2 5     Eag Related Protein 32
ERG32 3 5     Ether-A-Go-Go Related Gene Potassium Channel 32
Eag-Related Protein 32 3     Potassium Channel Subunit HERG-32
Ether-A-Go-Go-Related Gene Potassium Channel 32 3     Potassium Voltage-Gated Channel Subfamily H Member 72
Ether-A-Go-Go-Related Protein 32 3     HERG-31
Voltage-Gated Potassium Channel Subunit Kv11.32 3     

External Ids:    HGNC: 188631   Entrez Gene: 901342   Ensembl: ENSG000001846117   OMIM: 6081695   UniProtKB: Q9NS403   

Export aliases for KCNH7 gene to outside databases

Previous GC identifers: GC02M161281 GC02M161756 GC02M163430 GC02M163053 GC02M162936 GC02M155110


Summaries
for KCNH7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNH7:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming
(alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding
distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP
and subunit assembly

summary for KCNH7:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH7


Genomic Views
for KCNH7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH7 gene promoter:
         E2F   E2F-1   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNH7 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNH7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.3

KCNH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M163191:  view genomic region     (about GC identifiers)

Start:
 163,227,917 bp from pter      End:
 163,695,240 bp from pter
Size:
 467,324 bases      Orientation:
 minus strand

Proteins
for KCNH7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 7  
Size: 1196 amino acids; 135000 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By
similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAD01946.1; Type=Frameshift; Positions=792, 795;
Secondary accessions: Q53QU4 Q53TB7 Q53TP9 Q8IV15
Alternative splicing: 2 isoforms:  Q9NS40-1   Q9NS40-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNH7: NX_Q9NS40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NS40

    • KCNH7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_150375.2  NP_775185.1  

    ENSEMBL proteins: 
     ENSP00000331727   ENSP00000333781  
    Reactome Protein details: Q9NS40
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    Uscn Proteins for KCNH7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    KCNH7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KCNH7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNH7 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR003967 K_chnl_volt-dep_ERG
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9NS40

    ProtoNet protein and cluster: Q9NS40

    5 Blocks protein families:
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003967 ERG potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Function
    for KCNH7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP
    and subunit assembly

    miRNA
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    hsa-miR-3910 hsa-miR-448 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-449a hsa-miR-507 hsa-miR-1297 hsa-miR-570
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005242inward rectifier potassium channel activity IEA--
    GO:0005249voltage-gated potassium channel activity ----
    GO:0005267potassium channel activity ----


    KCNH7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNH7:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Kcnh7tm1Lex for KCNH7
         1 MGI phenotypic allele for Kcnh7 (no phenotypes)

    KCNH7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNH7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Voltage gated Potassium channels0.43
    2Potassium transporters: inward current
    		Potassium transporters: inward current1.00
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    4Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNH7
        Potassium transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNH7
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNH7
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNH7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNH7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for KCNH7 (Q9NS403 ENSP000003317274) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNB1ENSP000003608064STRING: ENSP00000360806
    KCNH1ENSP000002717514STRING: ENSP00000271751
    KCNH2ENSP000002621864STRING: ENSP00000262186
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006813potassium ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0007623circadian rhythm IEA--
    GO:0051291protein heterooligomerization IEA--


    KCNH7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNH7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    NS 1643hERG channel activator. Antiarrhythmic[448895-37-2]
    DofetilidehERG channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[115256-11-6]
    E-4031 dihydrochloridehERG channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNH7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    5 DrugBank Compounds for KCNH7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetinhibitor15926871 9257085
    Miconazole-- 22916-47-8targetinhibitor8760033 15778703
    DoxazosinDoxazosin mesilate (see all 2)74191-85-8targetinhibitor15098086
    PrazosinPrazocin (see all 6)19216-56-9targetinhibitor15098086
    TerazosinAbbott 45975 (see all 8)63590-64-7targetinhibitor15098086

    Search CenterWatch for drugs/clinical trials and news about KCNH7 

    Transcripts
    for KCNH7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNH7 gene (2 alternative transcripts): 
    NM_033272.3  NM_173162.2  

    Unigene Cluster for KCNH7:

    Potassium voltage-gated channel, subfamily H (eag-related), member 7
    Hs.657413  [show with all ESTs]
    Unigene Representative Sequence: NM_033272
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332142(uc002uch.2) ENST00000328032(uc002uci.3) ENST00000477019


    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNH7 (see all 25):
    hsa-miR-3910 hsa-miR-448 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-449a hsa-miR-507 hsa-miR-1297 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: KCNH7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF032897.1 AK098545.1 BC035815.1 

    4 DOTS entries:

    DT.40110642  DT.75112197  DT.40120858  DT.102834918 

    24/35 AceView cDNA sequences (see all 35):

    AK098545 CD634935 NM_033272 CD634932 NM_173162 AA496138 BC035815 CD634938 
    CD634945 CD634936 CD634939 BG200964 CD634953 AF032897 CD634933 AA496139 
    BG617817 U48352 CD634943 CD634928 CD634930 CD634941 CD634952 CD634947 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -                 -                     
    SP2:                                                                  


    ECgene alternative splicing isoforms for KCNH7

    Expression
    for KCNH7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNH7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATGTATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNH7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNH7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNH7

    SOURCE GeneReport for Unigene cluster: Hs.657413

    UniProtKB/Swiss-Prot: KCNH7_HUMAN, Q9NS40
    Tissue specificity: Expressed in prolactin-secreting adenomas

        SABiosciences Expression via Pathway-Focused PCR Array including KCNH7: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for KCNH7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KCNH7 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNH71 potassium voltage-gated channel, subfamily H (eag-related), more 80.38(n)
    86.87(a)    		   424184  XM_422030.3  XP_422030.3 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNH76
    KCNH26
    		 --
    		 84(a)
    55(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343359.1(184702-327417)
    GL343807.1(122230-201227)
    zebrafish
    (Danio rerio)    		 Actinopterygii kcnh71 potassium voltage-gated channel, subfamily H (eag-related), more 65.68(n)
    70.51(a)    		   560289  XM_683686.3  XP_688778.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sei6
    		 seizure
    		 46(a)
    		 1 → many
    		 2R(19936728-19940562)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-1036
    		 UNCoordinated family member (unc-103)
    		 46(a)
    		 1 → many
    		 III(4121438-4146421)
    rice
    (Oryza sativa)    		 Liliopsida Os01g07567001 hypothetical protein 39.67(n)
    26.57(a)    		   4325143  NM_001050825.1  NP_001044290.1 


    ENSEMBL Gene Tree for KCNH7 (if available)
    TreeFam Gene Tree for KCNH7 (if available) 

    Paralogs
    for KCNH7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNH7 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  HCN22  KCNH42  CNGA22  
    CNGA12  HCN12  KCNH22  CNGB12  CNGA42  CNGA32  CNGB32  KCNH12  
    KCNH82  
    4 SIMAP similar genes for KCNH7 using alignment to 1 protein entry:     KCNH7_HUMAN:
    KCNH2    KCNH1    KCNH5    KCNH6

    KCNH7 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNH7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7687 NCBI SNPs in KCNH7 are shown (see all 7687)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1834297121,2
    		--163227445(+) ATTTTA/TAAACA 1 -- ds50010--------
    rs1871494551,2
    		--163227456(+) TTTTTA/TGTAGA 1 -- ds50010--------
    rs751643401,2
    		F,--163227550(+) AGTTTG/TTGTTA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1487962221,2
    		--163227612(+) AAAAAC/GCAAAA 1 -- ds50010--------
    rs1424711941,2
    		--163227761(+) GGATAC/TGGCTT 1 -- ds50010--------
    rs1919191701,2
    		--163227830(+) ATGAAC/TGTAAT 1 -- ds50010--------
    rs787523211,2
    		F,--163227849(+) AACATC/TTTGAT 1 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1512959151,2
    		--163227985(+) TTTGCA/GTGGAA 1 -- ut310--------
    rs1397086861,2
    		--163228046(+) TCCATA/GCAAGA 1 -- ut310--------
    rs1835095961,2
    		--163228238(+) TGGTAA/CCTTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KCNH7 (163227917 - 163477917 bp, first 250kb of KCNH7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for KCNH7
         2 CNVs: 98042 98043
         5 Indels: 61851 40383 45894 12105 42833

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    Disorders / Diseases
    for KCNH7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNH7 for disorders           About GeneDecksing

    OMIM gene information: 608169    OMIM disorders: --

    5 diseases for KCNH7:    About MalaCards
    neuronitis    multiple sclerosis    gout    seizures
    adenoma

    Human Genome Epidemiology (HuGE) Navigator: KCNH7 (6 documents)

    Export disorders for KCNH7 gene to outside databases

    Publications
    for KCNH7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNH7 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with KCNH7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    2. HERG K(+) currents in human prolactin-secreting adenoma cells. (PubMed id 12634931)1, 2 Bauer C.K.... Schwarz J.R. (2003)
    3. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. A genome-wide association study identifies new psoria sis susceptibility loci and an interaction between HLA-C and ERAP1. (PubMed id 20953190)1  ....Trembath R.C. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients. (PubMed id 19156166)1 Couturier N....Brassat D. (2009)
    9. IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk. (PubMed id 18285833)1 Martinez A....Urcelay E. (2008)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)

    External Searches for KCNH7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNH7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90134 HGNC: 18863 AceView: KCNH7 Ensembl:ENSG00000184611 euGenes: HUgn90134
    ECgene: KCNH7 H-InvDB: KCNH7

    Other Databases showing KCNH7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNH7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNH7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNH7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNH7 gene:
    Search GeneIP for patents involving KCNH7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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