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Aliases for KCNH6 Gene

Aliases for KCNH6 Gene

  • Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 6 2 3
  • HERG2 3 4 6
  • Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 6 2 3
  • Voltage-Gated Potassium Channel Subunit Kv11.2 3 4
  • Ether-A-Go-Go-Related Protein 2 3 4
  • HERG-2 3 4
  • ERG-2 3 4
  • ERG2 3 4
  • Potassium Voltage-Gated Channel Subfamily H Member 6 3
  • Ether-A-Go-Go-Related Gene Potassium Channel 2 4
  • Eag-Related Gene Member 2 3
  • Eag-Related Protein 2 4
  • Kv11.2 3

External Ids for KCNH6 Gene

Summaries for KCNH6 Gene

Entrez Gene Summary for KCNH6 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for KCNH6 Gene

KCNH6 (Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 6) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include signal transducer activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for KCNH6 Gene

  • Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.

Tocris Summary for KCNH6 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNH6 Gene

Genomics for KCNH6 Gene

Genomic Location for KCNH6 Gene

Start:
63,523,334 bp from pter
End:
63,548,977 bp from pter
Size:
25,644 bases
Orientation:
Plus strand

Genomic View for KCNH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNH6 Gene

Regulatory Elements for KCNH6 Gene

Proteins for KCNH6 Gene

  • Protein details for KCNH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H252-KCNH6_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily H member 6
    Protein Accession:
    Q9H252
    Secondary Accessions:
    • Q9BRD7

    Protein attributes for KCNH6 Gene

    Size:
    994 amino acids
    Molecular mass:
    109925 Da
    Quaternary structure:
    • The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By similarity).

    Alternative splice isoforms for KCNH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNH6 Gene

Proteomics data for KCNH6 Gene at MOPED

Post-translational modifications for KCNH6 Gene

Other Protein References for KCNH6 Gene

No data available for DME Specific Peptides for KCNH6 Gene

Domains for KCNH6 Gene

Gene Families for KCNH6 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H252

UniProtKB/Swiss-Prot:

KCNH6_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q9H252
  • Contains 1 cyclic nucleotide-binding domain.:
    • Q9H252
  • Contains 1 PAC (PAS-associated C-terminal) domain.:
    • Q9H252
  • Contains 1 PAS (PER-ARNT-SIM) domain.:
    • Q9H252
Family:
  • Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily.:
    • Q9H252
genes like me logo Genes that share domains with KCNH6: view

Function for KCNH6 Gene

Molecular function for KCNH6 Gene

UniProtKB/Swiss-Prot Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.

Gene Ontology (GO) - Molecular Function for KCNH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNH6: view

Phenotypes for KCNH6 Gene

GenomeRNAi human phenotypes for KCNH6:
genes like me logo Genes that share phenotypes with KCNH6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNH6 Gene

Localization for KCNH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNH6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNH6 Gene COMPARTMENTS Subcellular localization image for KCNH6 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with KCNH6: view

Pathways for KCNH6 Gene

genes like me logo Genes that share pathways with KCNH6: view

Pathways by source for KCNH6 Gene

1 Qiagen pathway for KCNH6 Gene

Interacting Proteins for KCNH6 Gene

Gene Ontology (GO) - Biological Process for KCNH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006811 ion transport --
GO:0007165 signal transduction IEA --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNH6: view

Compounds for KCNH6 Gene

(5) Tocris Compounds for KCNH6 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(1) HMDB Compounds for KCNH6 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(5) Drugbank Compounds for KCNH6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Doxazosin
  • Doxazosin mesilate
74191-85-8 target inhibitor
Ibutilide
  • Ibutilida [INN-Spanish]
122647-32-9 target inhibitor
Miconazole
22916-47-8 target inhibitor
Prazosin
  • Prazocin
19216-56-9 target inhibitor
Terazosin
  • Abbott 45975
63590-64-7 target inhibitor

(1) IUPHAR Ligand for KCNH6 Gene

Ligand Type Action Affinity Pubmed IDs
NS1643 Activator None 4.9

(3) Novoseek inferred chemical compound relationships for KCNH6 Gene

Compound -log(P) Hits PubMed IDs
ergosterol 75.5 1
sterol 69.6 2
squalene 62.9 1
genes like me logo Genes that share compounds with KCNH6: view

Transcripts for KCNH6 Gene

Unigene Clusters for KCNH6 Gene

Potassium voltage-gated channel, subfamily H (eag-related), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNH6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for KCNH6 Gene

GeneLoc Exon Structure for
KCNH6
ECgene alternative splicing isoforms for
KCNH6

Expression for KCNH6 Gene

mRNA expression in normal human tissues for KCNH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNH6 Gene

This gene is overexpressed in Kidney - Cortex (17.3), Pituitary (7.7), Prostate (5.9), and Small Intestine - Terminal Ileum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNH6 Gene

SOURCE GeneReport for Unigene cluster for KCNH6 Gene Hs.591177

mRNA Expression by UniProt/SwissProt for KCNH6 Gene

Q9H252-KCNH6_HUMAN
Tissue specificity: Expressed in prolactin-secreting adenomas.
genes like me logo Genes that share expressions with KCNH6: view

Orthologs for KCNH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNH6 35
  • 99.41 (n)
  • 99.12 (a)
KCNH6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNH6 35
  • 89.73 (n)
  • 90.91 (a)
KCNH6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNH6 35
  • 89.35 (n)
  • 90.37 (a)
KCNH6 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnh6 35
  • 87.51 (n)
  • 90.74 (a)
Kcnh6 16
Kcnh6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNH6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kcnh6 35
  • 87.16 (n)
  • 90.32 (a)
chicken
(Gallus gallus)
Aves KCNH6 35
  • 76.3 (n)
  • 75.41 (a)
KCNH6 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485121 35
  • 69.03 (n)
  • 72.14 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnh6 35
  • 67.99 (n)
  • 68.49 (a)
si:dkey-240h6.1 36
  • 48 (a)
ManyToMany
Species with no ortholog for KCNH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNH6 Gene

ENSEMBL:
Gene Tree for KCNH6 (if available)
TreeFam:
Gene Tree for KCNH6 (if available)

Paralogs for KCNH6 Gene

Selected SIMAP similar genes for KCNH6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNH6: view

Variants for KCNH6 Gene

Sequence variations from dbSNP and Humsavar for KCNH6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs867640 -- 63,524,584(-) GCCAG(A/G)ACCAG intron-variant
rs867641 -- 63,524,257(-) TCGCA(C/G)GTGCA reference, synonymous-codon, intron-variant
rs883990 -- 63,523,895(+) CACAT(C/G)CCTGC intron-variant
rs3815004 -- 63,521,963(+) TGCCT(A/G)AGGTG upstream-variant-2KB
rs4257270 -- 63,524,932(+) GAAGC(A/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNH6 Gene

Variant ID Type Subtype PubMed ID
nsv908683 CNV Loss 21882294
esv2675657 CNV Deletion 23128226
nsv507852 CNV Insertion 20534489

Relevant External Links for KCNH6 Gene

HapMap Linkage Disequilibrium report
KCNH6
Human Gene Mutation Database (HGMD)
KCNH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNH6 Gene

Disorders for KCNH6 Gene

Relevant External Links for KCNH6

Human Genome Epidemiology (HuGE) Navigator
KCNH6
genes like me logo Genes that share disorders with KCNH6: view

No data available for UniProtKB/Swiss-Prot for KCNH6 Gene

Publications for KCNH6 Gene

  1. HERG K(+) currents in human prolactin-secreting adenoma cells. (PMID: 12634931) Bauer C.K. … Schwarz J.R. (Pflugers Arch. 2003) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3

Products for KCNH6 Gene

Sources for KCNH6 Gene

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