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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNH6 Gene

protein-coding   GIFtS: 60
GCID: GC17P061600

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member
61 2
     Kv11.22
Ether-A-Go-Go-Related Protein 22 3     Eag-Related Gene Member 22
Voltage-Gated Potassium Channel Subunit Kv11.22 3     Potassium Voltage-Gated Channel Subfamily H Member 62
ERG-22 3     Eag-Related Protein 23
ERG22 3     Ether-A-Go-Go-Related Gene Potassium Channel 23
hERG-22 3     hERG23
HERG22     

External Ids:    HGNC: 188621   Entrez Gene: 810332   Ensembl: ENSG000001738267   OMIM: 6081685   UniProtKB: Q9H2523   

Export aliases for KCNH6 gene to outside databases

Previous GC identifers: GC17P061251 GC17P064027 GC17P061941 GC17P062074 GC17P058954 GC17P056966


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNH6 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a
pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different
isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for KCNH6 Gene: 
KCNH6 (potassium voltage-gated channel, subfamily H (eag-related), member 6) is a protein-coding gene. Diseases associated with KCNH6 include acute lymphoblastic leukemia, and chronic lymphocytic leukemia, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include voltage-gated potassium channel activity. An important paralog of this gene is KCNH3.

UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying
current (By similarity). Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH6 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH6 gene promoter:
         CREB   RFX1   POU2F1   POU2F1a   COMP1   NRSF form 1   NRSF form 2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNH6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNH6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

KCNH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061600:  view genomic region     (about GC identifiers)

Start:
61,600,695 bp from pter      End:
61,626,338 bp from pter
Size:
25,644 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 6  
Size: 994 amino acids; 109925 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By
similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9BRD7
Alternative splicing: 3 isoforms:  Q9H252-1   Q9H252-2   Q9H252-3   

Explore the universe of human proteins at neXtProt for KCNH6: NX_Q9H252

Explore proteomics data for KCNH6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H252

  • KCNH6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNH6 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001265848.1  NP_001265849.1  NP_110406.1  NP_775115.1  

    ENSEMBL proteins: 
     ENSP00000463830   ENSP00000464672   ENSP00000462417   ENSP00000318212   ENSP00000463533  
     ENSP00000396900  
    Reactome Protein details: Q9H252
    Human Recombinant Protein Products for KCNH6: 
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    Cloud-Clone Corp. Proteins for KCNH6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IBA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    KCNH6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv11.2 
    Voltage-gated potassium channels

    5/8 InterPro protein domains (see all 8):
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR003967 K_chnl_volt-dep_ERG
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9H252

    ProtoNet protein and cluster: Q9H252

    5/7 Blocks protein domains (see all 7):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003950 ELK potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    KCNH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNH6_HUMAN, Q9H252
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying
    current (By similarity). Channel properties may be modulated by cAMP and subunit assembly

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity IBA--
         
    KCNH6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNH6:
     Synthetic lethal with cisplati 

         1 MGI phenotypic allele for Kcnh6 (no phenotypes)

    KCNH6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kcnh6tm1Lex for KCNH6

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNH6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Potassium transporters: inward current
    Potassium transporters: inward current
    4Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNH6
        Potassium transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNH6
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNH6
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNH6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for KCNH6 (ENSP000003182124) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    KCNA5ENSP000002523214STRING: ENSP00000252321
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006811ion transport ----
    GO:0007165signal transduction ----
    GO:0007268synaptic transmission TAS--
    GO:0042391regulation of membrane potential IBA--

    KCNH6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNH6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNH6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    5 DrugBank Compounds for KCNH6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IbutilideIbutilida [INN-Spanish] (see all 3)122647-32-9targetinhibitor15926871 9257085
    Miconazole-- 22916-47-8targetinhibitor8760033 15778703
    DoxazosinDoxazosin mesilate (see all 2)74191-85-8targetinhibitor15098086
    PrazosinPrazocin (see all 6)19216-56-9targetinhibitor15098086
    TerazosinAbbott 45975 (see all 8)63590-64-7targetinhibitor15098086

    1 IUPHAR Ligand for KCNH6 (Kv11.2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    NS1643
    ActivatorNone4.917610913

    3 Novoseek inferred chemical compound relationships for KCNH6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ergosterol 75.5 1 11353609 (1)
    sterol 69.6 2 15855491 (1), 16033255 (1)
    squalene 62.9 1 15328107 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNH6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNH6 gene (4 alternative transcripts): 
    NM_001278919.1  NM_001278920.1  NM_030779.3  NM_173092.2  

    Unigene Cluster for KCNH6:

    Potassium voltage-gated channel, subfamily H (eag-related), member 6
    Hs.591177  [show with all ESTs]
    Unigene Representative Sequence: NM_030779
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581784(uc002jaz.1) ENST00000580652(uc002jax.1) ENST00000583465
    ENST00000314672 ENST00000583023(uc002jay.3 uc010wpl.2 uc010wpm.2)
    ENST00000456941
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    Additional mRNA sequence: 

    AF311913.1 AK090969.1 AK091877.1 AK296498.1 AK298363.1 BC006334.2 

    4 DOTS entries:

    DT.92001686  DT.40246903  DT.91740938  DT.91853909 

    24/25 AceView cDNA sequences (see all 25):

    NM_030779 BU170580 NM_173092 AF311913 CD632739 BF685466 AK090969 BM461490 
    CD632731 CD632727 CD632735 BG395842 AA908657 AK091877 BM561167 AX746709 
    CD632733 AX747233 H96171 BC006334 CD632729 BE465143 BE672839 CD632737 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                        -                                   -                       -         
    SP2:                                                        -                                                                     
    SP3:                                                                                            -                                 
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for KCNH6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNH6 expression in normal human tissues (normalized intensities)      KCNH6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGACAGT
    KCNH6 Expression
    About this image


    KCNH6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud

    See KCNH6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNH6

    SOURCE GeneReport for Unigene cluster: Hs.591177

    UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252
    Tissue specificity: Expressed in prolactin-secreting adenomas

        SABiosciences Expression via Pathway-Focused PCR Array including KCNH6: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNH6 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnh61 , 5 potassium voltage-gated channel, subfamily H (eag-related), more1, 5 87.51(n)1
    90.74(a)1
      11 (68.87 cM)5
    1927751  NM_001037712.11  NP_001032801.11 
     1060081245 
    chicken
    (Gallus gallus)
    Aves KCNH61 potassium voltage-gated channel, subfamily H (eag-related), more 74.51(n)
    72.74(a)
      414871  XM_418075.3  XP_418075.3 
    lizard
    (Anolis carolinensis)
    Reptilia KCNH66
    Uncharacterized protein
    67(a)
    1 ↔ 1
    6(60982089-61144436)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnh21 potassium voltage-gated channel, subfamily H (eag-related), more 67.52(n)
    68.45(a)
      405763  NM_212837.1  NP_998002.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sei6
    seizure
    45(a)
    1 → many
    2R(19936728-19940562)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1031 Protein UNC-103 58.51(n)
    69.24(a)
      175527  NM_001129210.1  NP_001122682.1 


    ENSEMBL Gene Tree for KCNH6 (if available)
    TreeFam Gene Tree for KCNH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNH6 gene
    KCNH32  KCNH52  HCN32  HCN42  KCNH42  HCN22  CNGA22  CNGA12  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    7 SIMAP similar genes for KCNH6 using alignment to 3 protein entries:     KCNH6_HUMAN (see all proteins):
    KCNH2    KCNH8    KCNH5    KCNH1    KCNH7    KCNH4
    KCNH3

    KCNH6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in KCNH6 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422290251,2
    --61598714(+) GCTCTA/GTAAGA 2 -- us2k10--------
    rs1507116651,2
    --61598800(+) GGAAAA/GTGATG 2 -- us2k10--------
    rs1394856811,2
    C--61598822(+) TGAATC/GAATGA 2 -- us2k10--------
    rs1451176261,2
    --61598904(+) AGCCCC/TTTCTT 2 -- us2k10--------
    rs1996946271,2
    C--61598911(+) TCTTTC/TCCTCC 2 -- us2k10--------
    rs1475999671,2
    --61598948(+) AGCCAC/GGACAT 2 -- us2k10--------
    rs1476696851,2
    C--61599028(+) GACAA-/ACACACA 2 -- us2k10--------
    rs1852415041,2
    --61599031(+) AAACAA/CACATC 2 -- us2k10--------
    rs1425368731,2
    C--61599149(+) ATATTC/TCTTTC 2 -- us2k10--------
    rs1908831201,2
    --61599185(+) TGTTCA/TTCAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNH6 (61600695 - 61626338 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNH6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675657CNV Deletion23128226
    nsv507852CNV Insertion20534489
    nsv908683CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608168    OMIM disorders: --

    11 diseases for KCNH6:    About MalaCards
    acute lymphoblastic leukemia    chronic lymphocytic leukemia    lymphoblastic leukemia    neuropathy
    schizophrenia    crohn's disease    adenoma    leukemia
    neuronitis    prostate cancer    prostatitis


    KCNH6 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KCNH6 (1 document)

    Export disorders for KCNH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNH6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with KCNH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HERG K(+) currents in human prolactin-secreting adenoma cells. (PubMed id 12634931)1, 2, 9 Bauer C.K.... Schwarz J.R. (2003)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    6. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation. (PubMed id 15926871)7 Doggrell S.A. and Hancox J.C. (2005)
    9. Blockade of HERG cardiac K+ current by antifungal drug miconazole. (PubMed id 15778703)7 Kikuchi K....Nakashima Y. (2005)
    10. Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. (PubMed id 15098086)7 Thomas D....Karle C.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81033 HGNC: 18862 AceView: KCNH6 Ensembl:ENSG00000173826 euGenes: HUgn81033
    ECgene: KCNH6 H-InvDB: KCNH6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNH6 gene:
    Search GeneIP for patents involving KCNH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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