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KCNH6 Gene

protein-coding GIFtS: 54

GC17P058954

potassium voltage-gated channel, subfamily H (eag-related), member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ERG2 ^², ³
HERG2 ^¹, ², ³
Kv11.2 ^¹, ²
erg2 ^¹

Descriptions
Eag-related protein 2 ^³
Ether-a-go-go-related gene potassium channel 2 ^³
Ether-a-go-go-related protein 2 ^³
Voltage-gated potassium channel subunit Kv11.2 ^³
eag related protein 2 ^²
eag-related gene member 2 ^²
ether-a-go-go related gene potassium channel 2 ^²
potassium voltage-gated channel, subfamily H (eag-related), member 6 ^²
potassium voltage-gated channel, subfamily H, member 6 ^²

External Ids
HGNC: 18862¹
Entrez Gene: 81033²
UniProtKB: Q9H252³
Ensembl: ENSG00000173826⁷

Search outside databases for aliases for KCNH6 gene

Previous GC identifers: GC17P061251 GC17P064027 GC17P061941 GC17P062074

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNH6:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a

member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha)

subunit. Several alternatively spliced transcript variants have been identified from this gene,

but the full-length nature of only two transcript variants has been determined. [provided by

RefSeq]

UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252

Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly

activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and

subunit assembly

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNH6 gene

Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3

KCNH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P058954: (about GC identifiers)

Start:	58,954,427 bp from pter
End:	59,160,897 bp from pter
Size:	206,471 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily H member 6

Size: 994 amino acids; 109925 Da

Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of

pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with

KCNH2/ERG1 and KCNH7/ERG3 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q9BRD7

Alternative splicing: 3 isoforms: Q9H252-1 Q9H252-2 Q9H252-3 (Experimental confirmation may be lacking for some isoforms)

REFSEQ proteins (2 alternative transcripts):

NP_110406.1 NP_775115.1

ENSEMBL proteins:

ENSP00000376695 ENSP00000309393 ENSP00000318212

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNH6)
	Human Recombinant Proteins from Abnova (KCNH6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNH6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNH6
	Sigma-Aldrich Antibodies for KCNH6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNH6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNH6)
	Novus Biologicals Antibody for KCNH6

Assays for KCNH6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H252

ProtoNet protein and cluster: Q9H252

5/7 Blocks protein families (see all 7 ):

IPB000014 PAS domain

IPB000595 Cyclic nucleotide-binding domain

IPB001610 PAC motif

IPB003938 EAG/ELK/ERG potassium channel family signature

IPB003950 ELK potassium channel family signature

UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. H (Eag) subfamily

Similarity: Contains 1 cyclic nucleotide-binding domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNH6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNH6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_030779

Applied Biosystems Silencer® siRNAs for KCNH6

Sigma-Aldrich siRNA and siRNA Panels for KCNH6

Sigma-Aldrich shRNA Panels and shRNA for KCNH6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNH6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_030779
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_030779
untagged cDNA clones in CMV expression vector (see all 4): BC006334

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_030779

UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252

Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly

activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and

subunit assembly

1 MGI phenotypic allele for Kcnh6 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Interacting proteins for KCNH6 (ENSP00000318212³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERG	ENSP00000288319³	STRING (score=.873)
BRCA1	ENSP00000350283³	STRING (score=.848)
ETS2	ENSP00000353344³	STRING (score=.833)
ETS1	ENSP00000324578³	STRING (score=.83)
TMPRSS2	ENSP00000330330³	STRING (score=.744)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	IEA	--
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNH6

Browse Small Molecules at Sigma-Aldrich

Compounds for KCNH6 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
E-4031 dihydrochloride	HERG channel blocker; inhibits rapid delayed rectifier K+ current (IKr)	[113559-13-0]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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3 Novoseek chemical compound relationships for KCNH6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ergosterol	76.27	1	11353609 (1)
sterol	70.37	2	15855491 (1), 16033255 (1)
squalene	63.81	1	15328107 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNH6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNH6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_030779

Sigma-Aldrich siRNA and siRNA Panels for KCNH6

Sigma-Aldrich shRNA Panels and shRNA for KCNH6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_030779 NM_173092

REFSEQ mRNAs for KCNH6 gene (2 alternative transcripts):

NM_030779.2 NM_173092.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_030779 NM_173092

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_030779
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_030779
                                 untagged cDNA clones in CMV expression vector (see all 4): BC006334

Additional cDNA sequence:

AF311913.1 AK090969.1 AK091877.1 AK296498.1 AK298363.1 BC006334.2

4 DOTS entries:

DT.92001686 DT.40246903 DT.91740938 DT.91853909

24/25 AceView cDNA sequences (see all 25 ):

BU170580 AF311913 NM_173092 NM_030779 BM561167 CD632739 BF685466 CD632735

AX746709 CD632727 BM461490 CD632733 CD632731 CD632729 BG395842 BC006334

AX747233 AK091877 H96171 AA908657 AK090969 BE465143 BE672839 CD632737

highest scoring ESTs for KCNH6:

AA908657 AK091877 AF311913 AI699256 AK090969 BC006334 BE465143 BE672839 BF685466 BG395842

Unigene Cluster for KCNH6:

Potassium voltage-gated channel, subfamily H (eag-related), member 6

Hs.591177 [show with all ESTs]

Unigene Representative Sequence: NM_030779

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH6

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16
SP1:																			-												-								-
SP2:																			-
SP3:																															-
SP4:

About this scheme

ECgene alternative splicing isoforms for KCNH6

3 Ensembl transcripts including schematic representations:

ENST00000392968 ENST00000350328 ENST00000314672

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNH6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNH6

¹ / ² / ³

7 probe-sets matching KCNH6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
86319_at²^{, 3}	U95-D	1	0.62	1.00	1.00	1.00	AA908657	0.80	1.00	0.91	1
211045_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006334	0.60	1.00	0.82	1
221023_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_030779	0.60	1.00	0.82	1
211046_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006334	0.60	1.00	0.82	1
211045_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221023_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211046_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNH6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TCAGGACAGT

SOURCE GeneReport for Unigene cluster: Hs.591177
UniProtKB/Swiss-Prot: KCNH6_HUMAN, Q9H252
Tissue specificity: Expressed in prolactin-secreting adenomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNH6 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNH6¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	89.35(n) 90.37(a)	610684 XM_848226.1 XP_853319.1
cow (Bos taurus)	KCNH6¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	90.04(n) 91.82(a)	527872 XM_867795.2 XP_872888.2
rat (Rattus norvegicus)	Kcnh6¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	87.16(n) 90.32(a)	116745 NM_053937.1 NP_446389.1
mouse (Mus musculus)	Kcnh6^{1, 5}	11⁵	potassium voltage-gated channel, subfamily H (eag-related), more^{1, 5}	87.51(n)¹ 90.74(a)¹	192775¹ NM_001037712.1¹ NP_001032801.1¹ AK038513⁵ AL596331⁵ (see all 7)
chicken (Gallus gallus)	KCNH6¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	72.6(n) 70.67(a)	414871 XM_418075.2 XP_418075.2

About this table Species with no ortholog for KCNH6

ENSEMBL Gene Tree for KCNH6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNH6 gene

KCNH2² KCNH7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/113 NCBI SNPs in KCNH6 are shown (see all 113 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs35819807^1,2	C,F	58976784(-)	`TGTCCG/ATTGCC`	2	M/T	mis¹		5		NA EU EA WA	450
--	rs35399062^1,2	F	58961453(-)	`TGGTCC/TGCCTG`	2	G/R	mis¹		1		NA	30
--	rs9890263^1,2	C	58977373(+)	`CAGCCC/TCCCAG`	2	--	ng3¹ int¹		0	--	--	--	--
	rs3815004^1,2	H	58953056(+)	`TGCCTA/GAGGTG`	2	--	ng5¹ tfbs³		5		EA EU WA	1908
	rs7225568^1,2	A,C,F,H	58965155(+)	`AGCGAC/TCAGGA`	2	D/D	syn¹		13		NA EA EU WA	1060
	rs7224716^1,2	C,F,H	58965125(+)	`TTCACG/ACCCTA`	2	T/T	syn¹ ese³		5		EU EA WA NA	434
	rs7221517^1,2	C,F	58961440(+)	`TCTCAT/CGGCAG`	2	H/H	syn¹ ese³		1		NA	30
	rs35166012^1,2	F	58976731(-)	`GGACTA/GCAGTC`	2	C/C	syn¹		1		NA	30
	rs7221979^1,2	A,C,F,H	58968249(+)	`CCCAGA/GTAGTG`	2	--	int¹		8		EU EA WA NA	634
	rs4968656^1,2	A,C,F,H	58970691(+)	`TCCCCA/GTCACT`	2	--	int¹		12		EU EA WA NA	1202

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HapMap Linkage Disequilibrium images for KCNH6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608168

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for KCNH6 gene (see all 20 ):

HERG K(+) currents in human prolactin-secreting adenoma cells. (PubMed id 12634931)^{1, 3, 4} Bauer C.K.... Schwarz J.R. (2003)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
The eag family of K+ channels in Drosophila and mammals. (PubMed id 10414305)³ Ganetzky B....Titus S.A. (1999)
Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia. (PubMed id 19108891)¹ Bohne A....Baldus C.D. (2009)
Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. (PubMed id 16033255)¹ Laggner C....Moebius F.F. (2005)
Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans. (PubMed id 18338253)¹ Restano-Cassulini R....Possani L.D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 81033	HGNC: 18862	AceView: KCNH6	Ensembl:ENSG00000173826	euGenes: HUgn81033
ECgene: KCNH6	H-InvDB: KCNH6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNH6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNH6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNH6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNH6		Antibodies for KCNH6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNH6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for KCNH6
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KCNH6

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KCNH6 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for KCNH6

Summaries
for KCNH6

Genomic Location
for KCNH6

Proteins
for KCNH6

Protein Domains/
Families
for KCNH6

Gene Function
for KCNH6

Pathways & Interactions
for KCNH6

Drugs & Compounds
for KCNH6

Transcripts
for KCNH6

Expression
for KCNH6

Orthologs
for KCNH6

Paralogs
for KCNH6

SNPs/Variants
for KCNH6

Disorders & Mutations
for KCNH6

Medical News
for KCNH6

Publications
for KCNH6

Search for KCNH6

Genome Databases showing KCNH6

Other Databases showing KCNH6

Specialized Databases showing KCNH6

Licensable Technologies
for KCNH6

Services
for KCNH6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNH6 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor KCNH6

Summariesfor KCNH6

Genomic Locationfor KCNH6

Proteinsfor KCNH6

Protein Domains/Familiesfor KCNH6

Gene Functionfor KCNH6

Pathways & Interactionsfor KCNH6

Drugs & Compoundsfor KCNH6

Transcriptsfor KCNH6

Expression for KCNH6

Orthologsfor KCNH6

Paralogsfor KCNH6

SNPs/Variantsfor KCNH6

Disorders & Mutationsfor KCNH6

Medical Newsfor KCNH6

Publicationsfor KCNH6

Search for KCNH6

Genome Databases showing KCNH6

Other Databases showing KCNH6

Specialized Databases showing KCNH6

Licensable Technologiesfor KCNH6

Servicesfor KCNH6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNH6

Summaries
for KCNH6

Genomic Location
for KCNH6

Proteins
for KCNH6

Protein Domains/
Families
for KCNH6

Gene Function
for KCNH6

Pathways & Interactions
for KCNH6

Drugs & Compounds
for KCNH6

Transcripts
for KCNH6

Expression
for KCNH6

Orthologs
for KCNH6

Paralogs
for KCNH6

SNPs/Variants
for KCNH6

Disorders & Mutations
for KCNH6

Medical News
for KCNH6

Publications
for KCNH6

Licensable Technologies
for KCNH6

Services
for KCNH6