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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNH5 Gene

protein-coding   GIFtS: 60
GCID: GC14M063173

potassium voltage-gated channel, subfamily H (eag-related),...
 Explore 4 diseases affiliated with
KCNH5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNH5    

Aliases
for KCNH5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 51 2     HEAG21
H-EAG21 2     Eag21
Kv10.21 2     Ether-A-Go-Go-Related Potassium Channel 22
Ether-A-Go-Go Potassium Channel 22 3     Potassium Channel HEAG22
Voltage-Gated Potassium Channel Subunit Kv10.22 3     Potassium Voltage-Gated Channel Subfamily H Member 52
EAG22 3     Voltage-Gated Potassium Channel EAG22

External Ids:    HGNC: 62541   Entrez Gene: 271332   Ensembl: ENSG000001400157   OMIM: 6057165   UniProtKB: Q8NCM23   

Export aliases for KCNH5 gene to outside databases

Previous GC identifers: GC14M060501 GC14M056967 GC14M061163 GC14M062243 GC14M043339


Summaries
for KCNH5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNH5:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming
(alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in
differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward
rectifying current. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH5:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH5


Genomic Views
for KCNH5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH5 gene promoter:
         GR   AML1a   GR-beta   STAT5A   Arnt   PPAR-gamma1   c-Myb   STAT3   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNH5 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.1

KCNH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M063173:  view genomic region     (about GC identifiers)

Start:
 63,173,287 bp from pter      End:
 63,568,755 bp from pter
Size:
 395,469 bases      Orientation:
 minus strand

Proteins
for KCNH5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 5  
Size: 988 amino acids; 111877 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC11016.1; Type=Erroneous termination; Positions=436; Note=Translated as Gly;
Secondary accessions: C9JP98
Alternative splicing: 3 isoforms:  Q8NCM2-1   Q8NCM2-2   Q8NCM2-3   

Explore the universe of human proteins at neXtProt for KCNH5: NX_Q8NCM2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NCM2

    • KCNH5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_647479.2  NP_758963.1  NP_758964.1  

    ENSEMBL proteins: 
     ENSP00000321427   ENSP00000395439   ENSP00000378419   ENSP00000378415  
    Reactome Protein details: Q8NCM2
    Human Recombinant Protein Products: 
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    Uscn Proteins for KCNH5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA--
    GO:0016021integral to membrane IEA--


    KCNH5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNH5

    Protein Domains /
    Families
    for KCNH5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNH5 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR003949 K_chnl_volt-dep_EAG
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q8NCM2

    ProtoNet protein and cluster: Q8NCM2

    5/7 Blocks protein families (see all 7):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003949 EAG potassium channel signature


    UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Function
    for KCNH5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward
    rectifying current. Channel properties may be modulated by cAMP and subunit assembly

         Genatlas biochemistry entry for KCNH5:
    potassium voltage-gated channel, subfamily H (eag-related), member 5

    miRNA
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    hsa-miR-217 hsa-miR-16-2* hsa-miR-300 hsa-miR-7-2* hsa-miR-3942-5p hsa-miR-381 hsa-miR-1271 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): KCNH5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0005249voltage-gated potassium channel activity IEA--
    GO:0005516calmodulin binding IEA--


    KCNH5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for KCNH5:
     Increased G1 DNA content  Increased cell number in G1, s 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnh5):
     behavior/neurological  no phenotypic analysis 

    KCNH5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNH5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Potassium transporters: outward current0.42
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KCNH5
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNH5
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNH5
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNH5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for KCNH5 (Q8NCM23 ENSP000003214274) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA2P163893, ENSP000003145204I2D: score=1 STRING: ENSP00000314520
    KCNH1O952593, ENSP000002717514I2D: score=1 STRING: ENSP00000271751
    KCNAB2Q133033, ENSP000001642474I2D: score=1 STRING: ENSP00000164247
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CASKO149363I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007268synaptic transmission TAS--
    GO:0010389regulation of G2/M transition of mitotic cell cycle IDA--


    KCNH5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNH5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KCNH5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    1 Novoseek chemical compound relationship for KCNH5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 32.1 1 11943152 (1)

    Search CenterWatch for drugs/clinical trials and news about KCNH5 

    Transcripts
    for KCNH5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNH5 gene (3 alternative transcripts): 
    NM_139318.3  NM_172375.1  NM_172376.1  

    Unigene Cluster for KCNH5:

    Potassium voltage-gated channel, subfamily H (eag-related), member 5
    Hs.27043  [show with all ESTs]
    Unigene Representative Sequence: BC073979
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322893(uc001xfx.3 uc001xfy.3) ENST00000420622 ENST00000394968(uc001xfz.1)
    ENST00000394964(uc001xga.3)

    miRNA
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    hsa-miR-217 hsa-miR-16-2* hsa-miR-300 hsa-miR-7-2* hsa-miR-3942-5p hsa-miR-381 hsa-miR-1271 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): KCNH5 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF418206.1 AF472412.1 AF493798.1 BC043409.2 BC073979.1 

    4 DOTS entries:

    DT.100018940  DT.100018941  DT.97819289  DT.100741448 

    19 AceView cDNA sequences:

    F05455 F01716 AF472412 NM_172376 AF493798 NM_172375 AW628656 Z38438 
    NM_139318 BC073979 AF418206 BX281706 BC043409 F05456 AK074484 CD636893 
    U69185 CD636891 BQ439615 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -                                         -                                       
    SP2:                                                              -                       -               
    SP3:                                                              -                 -     -               
    SP4:              -     -                                                                                 


    ECgene alternative splicing isoforms for KCNH5

    Expression
    for KCNH5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGGATATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNH5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNH5

    SOURCE GeneReport for Unigene cluster: Hs.27043

    UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Tissue specificity: Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney

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    In Situ
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    Orthologs
    for KCNH5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KCNH5 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNH51 potassium voltage-gated channel, subfamily H (eag-related), more 84.99(n)
    95.85(a)    		   423514  XM_421414.2  XP_421414.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNH56
    		 --
    		 90(a)
    		 1 ↔ 1
    		 1(2566080-2796690)
    zebrafish
    (Danio rerio)    		 Actinopterygii kcnh51 potassium voltage-gated channel, subfamily H (eag-related), more 72.44(n)
    80.72(a)    		   100331767  XM_002664207.1  XP_002664253.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eag3 courtship behavior voltage-gated potassium
    channel    		 61(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea egl-23 channel protein 57(a)   V(1289525-1299037)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons KAT31 Potassium channel KAT3 41.38(n)
    28.05(a)    		   829400  NM_202936.1  NP_974665.1 


    ENSEMBL Gene Tree for KCNH5 (if available)
    TreeFam Gene Tree for KCNH5 (if available) 

    Paralogs
    for KCNH5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNH5 gene
    KCNH62  KCNH32  HCN32  HCN42  HCN22  KCNH42  CNGA22  CNGA12  
    HCN12  KCNH72  KCNH22  CNGB12  CNGA42  CNGA32  CNGB32  KCNH12  
    KCNH82  
    7 SIMAP similar genes for KCNH5 using alignment to 2 protein entries:     KCNH5_HUMAN (see all proteins):
    KCNH1    KCNH2    KCNH4    KCNH7    KCNH8    KCNH6
    KCNH3

    KCNH5 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNH5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6678 NCBI SNPs in KCNH5 are shown (see all 6678)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1882474731,2
    		--63173657(+) TATCCA/CACACT 2 -- ds50010--------
    rs1397905071,2
    		--63173930(+) TCTTCA/GAATAT 2 -- ds50010--------
    rs763464161,2
    		--63173964(+) TCATAC/TTCTTT 2 -- ut310--------
    rs1912932971,2
    		--63173997(+) ATAAAC/TGTAAA 2 -- ut310--------
    rs1827647391,2
    		--63174027(+) CATAAG/TATACA 2 -- ut310--------
    rs1876422041,2
    		--63174127(+) GTCATC/TATCTT 2 -- ut310--------
    rs1482004691,2
    		F--63174304(+) ATCTGG/TGGGGG 3 P syn1 ut311Minor allele frequency- T:0.00NA 4528
    rs2003823621,2
    		--63174305(+) TCTGGC/GGGGGT 3 P R ut31 mis10--------
    rs1503667791,2
    		C,F,--63174367(+) TCCGAC/GAGTAT 3 L ut31 syn12Minor allele frequency- G:0.00NA EU 5873
    rs2022017341,2
    		--63174405(+) TAGGGA/CAGTCA 3 A S mis1 ut310--------

    HapMap Linkage Disequilibrium report for KCNH5 (63173287 - 63423287 bp, first 250kb of KCNH5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for KCNH5
         3 CNVs: 76655 76654 101968
         1 Indel: 71910

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    Disorders / Diseases
    for KCNH5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNH5 for disorders           About GeneDecksing

    OMIM gene information: 605716    OMIM disorders: --

    4 diseases for KCNH5:    About MalaCards
    neuronitis    lung cancer    cerebritis    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: KCNH5 (4 documents)

    Export disorders for KCNH5 gene to outside databases

    Publications
    for KCNH5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNH5 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with KCNH5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional distinction of human EAG1 and EAG2 potassium channels. (PubMed id 11943152)1, 2, 9 Schoenherr R.... Heinemann S.H. (2002)
    2. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
    3. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular identification and characterisation of the human eag2 potassium channel. (PubMed id 12135768)1, 2 Ju M. and Wray D. (2002)
    7. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. (PubMed id 9738473)1, 3 Occhiodoro T.... Fischer-Lougheed J. (1998)
    8. [Three-dimensional structure of human Kv10.2 ion chann el studied by single particle electron microscopy and molecular modeling]. (PubMed id 22792721)1 Sokolova O.S....Kirpichnikov M.P. (2012)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for KCNH5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNH5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27133 HGNC: 6254 AceView: KCNH5 Ensembl:ENSG00000140015 euGenes: HUgn27133
    ECgene: KCNH5 H-InvDB: KCNH5

    Other Databases showing KCNH5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNH5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNH5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNH5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNH5 gene:
    Search GeneIP for patents involving KCNH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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