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Aliases for KCNH5 Gene

Aliases for KCNH5 Gene

  • Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 5 2 3
  • Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 5 2 3
  • Voltage-Gated Potassium Channel Subunit Kv10.2 3 4
  • HEAG2 3 4
  • EAG2 3 4
  • Potassium Voltage-Gated Channel Subfamily H Member 5 3
  • Ether-A-Go-Go-Related Potassium Channel 2 3
  • Ether-A-Go-Go Potassium Channel 2 4
  • H-EAG2 3
  • Kv10.2 3

External Ids for KCNH5 Gene

Previous GeneCards Identifiers for KCNH5 Gene

  • GC14M060501
  • GC14M056967
  • GC14M061163
  • GC14M062243
  • GC14M063173
  • GC14M043339

Summaries for KCNH5 Gene

Entrez Gene Summary for KCNH5 Gene

  • This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for KCNH5 Gene

KCNH5 (Potassium Channel, Voltage Gated Eag Related Subfamily H, Member 5) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include calmodulin binding and phosphorelay sensor kinase activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for KCNH5 Gene

  • Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly

Tocris Summary for KCNH5 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNH5 Gene

Genomics for KCNH5 Gene

Regulatory Elements for KCNH5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNH5 Gene

62,699,454 bp from pter
63,102,037 bp from pter
402,584 bases
Minus strand

Genomic View for KCNH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNH5 Gene

Proteins for KCNH5 Gene

  • Protein details for KCNH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium voltage-gated channel subfamily H member 5
    Protein Accession:
    Secondary Accessions:
    • C9JP98

    Protein attributes for KCNH5 Gene

    988 amino acids
    Molecular mass:
    111877 Da
    Quaternary structure:
    • The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable).
    • Sequence=BAC11016.1; Type=Erroneous termination; Positions=436; Note=Translated as Gly.; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNH5 Gene


neXtProt entry for KCNH5 Gene

Proteomics data for KCNH5 Gene at MOPED

Post-translational modifications for KCNH5 Gene

Other Protein References for KCNH5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNH5 Gene

Domains for KCNH5 Gene

Gene Families for KCNH5 Gene

  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels

Suggested Antigen Peptide Sequences for KCNH5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NCM2
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • Contains 1 cyclic nucleotide-binding domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 1 PAS (PER-ARNT-SIM) domain.
  • Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily.
genes like me logo Genes that share domains with KCNH5: view

Function for KCNH5 Gene

Molecular function for KCNH5 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel, subfamily H (eag-related), member 5
UniProtKB/Swiss-Prot Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly

Gene Ontology (GO) - Molecular Function for KCNH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000155 phosphorelay sensor kinase activity IEA --
GO:0004871 signal transducer activity --
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with KCNH5: view

Phenotypes for KCNH5 Gene

genes like me logo Genes that share phenotypes with KCNH5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNH5 Gene

Localization for KCNH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNH5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNH5 Gene COMPARTMENTS Subcellular localization image for KCNH5 gene
Compartment Confidence
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for KCNH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 22855790
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0009986 cell surface IDA 22855790
genes like me logo Genes that share ontologies with KCNH5: view

Pathways for KCNH5 Gene

genes like me logo Genes that share pathways with KCNH5: view

Pathways by source for KCNH5 Gene

1 Qiagen pathway for KCNH5 Gene

Gene Ontology (GO) - Biological Process for KCNH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000160 phosphorelay signal transduction system IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006811 ion transport --
GO:0007165 signal transduction --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with KCNH5: view

Compounds for KCNH5 Gene

(5) Tocris Compounds for KCNH5 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(1) HMDB Compounds for KCNH5 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP

(1) Novoseek inferred chemical compound relationships for KCNH5 Gene

Compound -log(P) Hits PubMed IDs
potassium 32.1 1
genes like me logo Genes that share compounds with KCNH5: view

Transcripts for KCNH5 Gene

Unigene Clusters for KCNH5 Gene

Potassium voltage-gated channel, subfamily H (eag-related), member 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNH5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNH5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - -
SP3: - - -
SP4: - -

Relevant External Links for KCNH5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNH5 Gene

mRNA expression in normal human tissues for KCNH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNH5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.6), Brain - Cortex (10.0), Brain - Anterior cingulate cortex (BA24) (6.2), Brain - Hypothalamus (4.4), and Brain - Amygdala (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNH5 Gene

SOURCE GeneReport for Unigene cluster for KCNH5 Gene Hs.27043

mRNA Expression by UniProt/SwissProt for KCNH5 Gene

Tissue specificity: Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney
genes like me logo Genes that share expressions with KCNH5: view

Expression partners for KCNH5 Gene

In Situ Assay Products

No data available for Protein differential expression in normal tissues for KCNH5 Gene

Orthologs for KCNH5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNH5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNH5 35
  • 93.69 (n)
  • 99.09 (a)
KCNH5 36
  • 99 (a)
(Canis familiaris)
Mammalia KCNH5 35
  • 93.83 (n)
  • 99.09 (a)
KCNH5 36
  • 99 (a)
(Mus musculus)
Mammalia Kcnh5 35
  • 91.33 (n)
  • 98.08 (a)
Kcnh5 16
Kcnh5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Kcnh5 35
  • 91.36 (n)
  • 98.28 (a)
(Monodelphis domestica)
Mammalia KCNH5 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia KCNH5 36
  • 94 (a)
(Pan troglodytes)
Mammalia KCNH5 36
  • 100 (a)
(Gallus gallus)
Aves KCNH5 35
  • 84.95 (n)
  • 95.85 (a)
KCNH5 36
  • 96 (a)
(Anolis carolinensis)
Reptilia KCNH5 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnh5 35
  • 81.38 (n)
  • 92.27 (a)
(Danio rerio)
Actinopterygii kcnh5a 35
  • 72.65 (n)
  • 81.85 (a)
kcnh5a 36
  • 72 (a)
kcnh5b 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta eag 37
  • 61 (a)
eag 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea egl-2 37
  • 57 (a)
egl-2 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for KCNH5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNH5 Gene

Gene Tree for KCNH5 (if available)
Gene Tree for KCNH5 (if available)

Paralogs for KCNH5 Gene

Selected SIMAP similar genes for KCNH5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNH5: view

Variants for KCNH5 Gene

Sequence variations from dbSNP and Humsavar for KCNH5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs171456 -- 62,817,013(-) aagtt(C/T)aataa intron-variant
rs171457 -- 62,838,827(-) TTACT(C/T)TTTCC intron-variant
rs171458 -- 62,822,969(+) ATACC(A/G)AAATA intron-variant
rs171459 -- 62,822,461(+) tatac(C/G)aacac intron-variant
rs173376 -- 62,814,740(-) agtgg(G/T)gtgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNH5 Gene

Variant ID Type Subtype PubMed ID
nsv902014 CNV Loss 21882294
nsv527675 CNV Gain 19592680
nsv507756 CNV Insertion 20534489
esv1128942 CNV Insertion 17803354
esv2497499 CNV Insertion 19546169
esv274258 CNV Insertion 20981092
esv270248 CNV Insertion 20981092
esv1264722 CNV Insertion 17803354
nsv902015 CNV Loss 21882294
esv275351 CNV Loss 21479260
dgv137n21 CNV Gain 19592680
nsv902016 CNV Loss 21882294
esv21487 CNV Loss 19812545

Relevant External Links for KCNH5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNH5 Gene

Disorders for KCNH5 Gene

Relevant External Links for KCNH5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KCNH5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KCNH5 Gene

Publications for KCNH5 Gene

  1. Functional distinction of human EAG1 and EAG2 potassium channels. (PMID: 11943152) Schoenherr R. … Heinemann S.H. (FEBS Lett. 2002) 3 4 23
  2. Molecular identification and characterisation of the human eag2 potassium channel. (PMID: 12135768) Ju M. … Wray D. (FEBS Lett. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3

Products for KCNH5 Gene

Sources for KCNH5 Gene

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