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Aliases & Descriptions for KCNH4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BEC2 2, 3 | | ELK1 2, 3 | | Kv12.3 1, 2 | | elk1 1 |
| | | Descriptions |
|---|
| Brain-specific eag-like channel 2 2, 3 | | ELK channel 1 2, 3 | | Ether-a-go-go-like potassium channel 1 2, 3 | | Voltage-gated potassium channel subunit Kv12.3 3 | | ether-a-go-go K(+) channel family member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 4 2 | | potassium voltage-gated channel, subfamily H, member 4 2 |
|
| | Search outside databases for aliases for KCNH4 genePrevious GC identifers: GC17M039865 GC17M042464 GC17M040217 GC17M040682 |
Summaries for KCNH4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNH4: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly |
Genomic Location for KCNH4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNH4 gene 
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21KCNH4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037562:
(about GC identifiers)
Start:
|
37,562,439 bp from pter |
End:
|
37,586,822 bp from pter |
Size:
|
24,384 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010755.15
| Proteins for KCNH4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily H member 4 Size: 1017 amino acids; 111693 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane proteinPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036417.1
ENSEMBL proteins: ENSP00000264661
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNH4: Assays for KCNH4: | Protein
Domains/ Families for KCNH4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UQ05
ProtoNet protein and cluster: Q9UQ05 5/6 Blocks protein families (see all 6
): IPB000014 PAS domain IPB000595 Cyclic nucleotide-binding domain IPB001610 PAC motif IPB003938 EAG/ELK/ERG potassium channel family signature IPB003950 ELK potassium channel family signature
UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. H (Eag) subfamilySimilarity: Contains 1 cyclic nucleotide-binding domainSimilarity: Contains 1 PAC (PAS-associated C-terminal) domainSimilarity: Contains 1 PAS (PER-ARNT-SIM) domain | Gene Function for KCNH4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012285
Applied Biosystems Silencer® siRNAs for KCNH4
Sigma-Aldrich siRNA and siRNA Panels for KCNH4  Sigma-Aldrich shRNA Panels and shRNA for KCNH4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012285                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012285                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012285 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012285
UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KCNH4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNH4 
5/75 Interacting proteins for KCNH4 (ENSP000002646613) via UniProtKB, MINT, and/or STRING (see all 75
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000160 | two-component signal transduction system (phosphorelay) |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
TAS | 10455180 | About this table
|
Drugs & Compounds for KCNH4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNH4 available from Tocris Bioscience About this table
|
Transcripts for KCNH4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012285
Sigma-Aldrich siRNA and siRNA Panels for KCNH4  Sigma-Aldrich shRNA Panels and shRNA for KCNH4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012285 REFSEQ mRNAs for KCNH4 gene: NM_012285.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012285               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012285                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012285                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012285  Additional cDNA sequence: AB022698.1 5 DOTS entries: DT.75138552 DT.75144132 DT.75195626 DT.95093587 DT.95146325 12 AceView cDNA sequences:AB022698 NM_012285 BX091763 BX283895 BM549668 BG758764 BQ447844 AI873041 AW084816 AI932262 BE702920 BM013212
highest scoring ESTs for KCNH4:AB022698 AW084816 NM_012285 AI873041 AI932262 BE702920 BG758764 BM013212 BM549668 BQ447844 Unigene Cluster for KCNH4: Potassium voltage-gated channel, subfamily H (eag-related), member 4 Hs.304081 [show with all ESTs]Unigene Representative Sequence: AB022698
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000264661
|
Expression for KCNH4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNH4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNH4
1 / 2 / 3 2 probe-sets matching KCNH4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTCTCACTCA
SOURCE GeneReport for Unigene cluster: Hs.304081 UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus |
Orthologs for KCNH4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNH4 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNH41 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
91.38(n) 92.72(a) |
607649 XM_844412.1 XP_849505.1 |
chimpanzee (Pan troglodytes) |
KCNH41 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
99.57(n) 99.61(a) |
742588 XM_001166613.1 XP_001166613.1 |
rat (Rattus norvegicus) |
Kcnh41 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
86.77(n) 89.85(a) |
114032 NM_053630.1 NP_446082.1 |
mouse (Mus musculus) |
Kcnh41, 5 |
11 (61.30 cM)5
|
potassium voltage-gated channel, subfamily H (eag-related), more1, 5 |
87.35(n)1 89.97(a)1 |
3807281 NM_001081194.11 NP_001074663.11 AL5914665 AL5914695 (see all 11) |
chicken (Gallus gallus) |
KCNH41 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
71.46(n) 70.04(a) |
772091 XM_001235279.1 XP_001235280.1 |
About this table Species with no ortholog for KCNH4
ENSEMBL Gene Tree for KCNH4 | Paralogs for KCNH4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNH4 gene
- KCNH32 KCNH82
|
SNPs/Variants for KCNH4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNH4 (up to first 250kb)
|
Disorders & Mutations for KCNH4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604528
|
Medical News for KCNH4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNH4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for KCNH4 gene (see all 13
): |
Search for KCNH4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNH4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNH4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNH4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNH4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNH4:

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| | | | Tocris compounds for KCNH4 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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