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KCNH4 Gene

protein-coding   GIFtS: 60
GCID: GC17M040308

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related),...

  See KCNH4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member
41 2
     ELK12 3
Brain-Specific Eag-Like Channel 22 3     ELK Channel 12 3
Ether-A-Go-Go-Like Potassium Channel 12 3     Kv12.32
Voltage-Gated Potassium Channel Subunit Kv12.32 3     Ether-A-Go-Go K(+) Channel Family Member2
BEC22 3     Potassium Voltage-Gated Channel Subfamily H Member 42

External Ids:    HGNC: 62531   Entrez Gene: 234152   Ensembl: ENSG000000895587   OMIM: 6045285   UniProtKB: Q9UQ053   

Export aliases for KCNH4 gene to outside databases

Previous GC identifers: GC17M039865 GC17M042464 GC17M040217 GC17M040682 GC17M037562 GC17M036074


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNH4 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a
pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may
be involved in cellular excitability of restricted neurons in the central nervous system. (provided by RefSeq,
Jul 2008)

GeneCards Summary for KCNH4 Gene:
KCNH4 (potassium voltage-gated channel, subfamily H (eag-related), member 4) is a protein-coding gene. Diseases associated with KCNH4 include campylobacteriosis. GO annotations related to this gene include phosphorelay sensor kinase activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows
no inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNH4 gene promoter:
         NRSF form 1   Tal-1beta   NRSF form 2   CREB   PPAR-gamma1   FOXJ2 (long isoform)   deltaCREB   ARP-1   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNH4 promoter sequence
   Search Chromatin IP Primers for KCNH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

KCNH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040308:  view genomic region     (about GC identifiers)

Start:
40,308,909 bp from pter      End:
40,333,296 bp from pter
Size:
24,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 4  
Size: 1017 amino acids; 111693 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits

Explore the universe of human proteins at neXtProt for KCNH4: NX_Q9UQ05

Explore proteomics data for KCNH4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn326, Asn414, Asn473
  • Modification sites at PhosphoSitePlus

  • See KCNH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036417.1  
    ENSEMBL proteins: 
     ENSP00000475564   ENSP00000264661  
    Reactome Protein details: Q9UQ05

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv12.3
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR003950 K_chnl_volt-dep_ELK
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9UQ05

    ProtoNet protein and cluster: Q9UQ05

    Selected Blocks protein domains (see all 6):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003950 ELK potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Find genes that share domains with KCNH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNH4_HUMAN, Q9UQ05
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows
    no inactivation. Channel properties may be modulated by cAMP and subunit assembly

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0004871signal transducer activity ----
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity IBA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KCNH4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNH4:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KCNH4

    miRNA
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    miRTarBase miRNAs that target KCNH4:
    hsa-mir-335-5p (MIRT018899), hsa-mir-26b-5p (MIRT030236)

    Block miRNA regulation of human, mouse, rat KCNH4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNH4 (see all 21):
    hsa-miR-596 hsa-miR-125a-5p hsa-miR-520a-5p hsa-miR-3150a-3p hsa-miR-23b* hsa-miR-661 hsa-miR-125b hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidKCNH4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNH4_HUMAN, Q9UQ05: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS10455180
    GO:0016020membrane ----

    Find genes that share ontologies with KCNH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNH4 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters outward current0.41
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Find genes that share SuperPaths with KCNH4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNH4
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNH4
        Voltage gated Potassium channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNH4
    Interactions:

        GeneGlobe Interaction Network for KCNH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNH4 (ENSP000002646614) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA5ENSP000002523214STRING: ENSP00000252321
    KCNA7ENSP000002214444STRING: ENSP00000221444
    KCNB1ENSP000003608064STRING: ENSP00000360806
    KCNC1ENSP000002659694STRING: ENSP00000265969
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000160phosphorelay signal transduction system ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS10455180
    GO:0007165signal transduction ----

    Find genes that share ontologies with KCNH4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNH4 gene: 
    NM_012285.2  

    Unigene Cluster for KCNH4:

    Potassium voltage-gated channel, subfamily H (eag-related), member 4
    Hs.304081  [show with all ESTs]
    Unigene Representative Sequence: NM_012285
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607371 ENST00000264661(uc002hzb.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KCNH4 (see all 21):
    hsa-miR-596 hsa-miR-125a-5p hsa-miR-520a-5p hsa-miR-3150a-3p hsa-miR-23b* hsa-miR-661 hsa-miR-125b hsa-miR-298
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    Additional mRNA sequence: AB022698.1 

    5 DOTS entries:

    DT.75138552  DT.75144132  DT.95093587  DT.75195626  DT.95146325 

    12 AceView cDNA sequences:

    BX091763 AB022698 NM_012285 BX283895 BG758764 BM549668 AI873041 BQ447844 
    BE702920 AI932262 AW084816 BM013212 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCACTCA
    KCNH4 Expression
    About this image

    KCNH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.304081

    UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
    Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate
    nucleus, and at lower levels in cerebral cortex, occipital and hippocampus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNH4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnh41 , 5 potassium voltage-gated channel, subfamily H (eag-related), more1, 5 87.35(n)1
    89.97(a)1
      11 (63.57 cM)5
    3807281  NM_001081194.21  NP_001074663.11 
     1007403765 
    chicken
    (Gallus gallus)
    Aves KCNH41 potassium voltage-gated channel, subfamily H (eag-related), more 72.1(n)
    71.7(a)
      772091  XM_001235279.3  XP_001235280.3 
    lizard
    (Anolis carolinensis)
    Reptilia KCNH46
    potassium voltage-gated channel, subfamily H (eag-...
    60(a)
    1 ↔ 1
    6(72778967-72849640)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcnh41 potassium voltage-gated channel, subfamily H (eag-related), more 66.93(n)
    69.46(a)
      100488431  XM_002942318.2  XP_002942364.2 
    zebrafish
    (Danio rerio)
    Actinopterygii kcnh41 potassium voltage-gated channel, subfamily H (eag-related), more 66.55(n)
    66.52(a)
      100148126  XM_001920618.3  XP_001920653.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta elk3 potassium ion transport potassium
    channel
    52(a)     --


    ENSEMBL Gene Tree for KCNH4 (if available)
    TreeFam Gene Tree for KCNH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNH4 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  HCN22  CNGA12  CNGA22  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    5 SIMAP similar genes for KCNH4 using alignment to 1 protein entry:     KCNH4_HUMAN:
    KCNH8    KCNH3    KCNH5    KCNH6    KCNH1

    Find genes that share paralogs with KCNH4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNH4 (see all 600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357714
    A colorectal cancer sample4--see VAR_0357712 G R mis40--------
    rs1407658851,2
    --40309354(+) AGCCTC/TCGCGC 1 -- int10--------
    rs1446163201,2
    C--40309358(+) TCCGCA/GCCTGG 1 -- int10--------
    rs1134036821,2
    F--40309630(+) TTTTTC/TGTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs780377091,2
    C,F--40309636(+) GTTTTG/ATTTTG 1 -- int11Minor allele frequency- A:0.04EA 120
    rs2017679851,2
    C--40309699(+) CTGCT-/CACTGC 1 -- int10--------
    rs1844187461,2
    --40309724(+) GGGCTC/TAAGAG 1 -- int10--------
    rs1895183221,2
    --40309897(+) CTGGAA/GTAGCT 1 -- int10--------
    rs1140431601,2
    C,F--40309898(+) TGGAGT/CAGCTG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1179524281,2
    F--40309926(+) CACTAC/TACCTG 1 -- int11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for KCNH4 (40308909 - 40333296 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908244CNV Loss21882294
    dgv3169n71CNV Loss21882294
    nsv908241CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNH4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604528    OMIM disorders: --

    1 disease for KCNH4:    
    About MalaCards
    campylobacteriosis

    1 disease from the University of Copenhagen DISEASES database for KCNH4:
    Campylobacteriosis

    Find genes that share disorders with KCNH4           About GenesLikeMe

    Genetic Association Database (GAD): KCNH4
    Human Genome Epidemiology (HuGE) Navigator: KCNH4 (3 documents)

    Export disorders for KCNH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNH4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with KCNH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)1, 2, 3, 9 Miyake A.... Furuichi K. (J. Biol. Chem. 1999)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    4. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)1, 9 Zou A.... Wickenden A.D. (Am. J. Physiol. 2003)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    7. Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. (PubMed id 11050086)9 Vanhoutte P....Caboche J. (J. Biol. Chem. 2001)
    8. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. (PubMed id 20126313)9 Sharma A....Eberwine J. (PLoS ONE 2010)
    9. Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients. (PubMed id 10891039)9 Kyosseva S.V....Karson C.N. (Arch. Gen. Psychiatry 2000)
    10. Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation. (PubMed id 19390590)9 Gokce O....Luthi-Carter R. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23415 HGNC: 6253 AceView: KCNH4 Ensembl:ENSG00000089558 euGenes: HUgn23415
    ECgene: KCNH4 H-InvDB: KCNH4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KCNH4 gene:
    Search GeneIP for patents involving KCNH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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