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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNH4 Gene

protein-coding   GIFtS: 59
GCID: GC17M040308

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related),...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member
41 2
     ELK12 3
Brain-Specific Eag-Like Channel 22 3     ELK Channel 12 3
Ether-A-Go-Go-Like Potassium Channel 12 3     Kv12.32
Voltage-Gated Potassium Channel Subunit Kv12.32 3     Ether-A-Go-Go K(+) Channel Family Member2
BEC22 3     Potassium Voltage-Gated Channel Subfamily H Member 42

External Ids:    HGNC: 62531   Entrez Gene: 234152   Ensembl: ENSG000000895587   OMIM: 6045285   UniProtKB: Q9UQ053   

Export aliases for KCNH4 gene to outside databases

Previous GC identifers: GC17M039865 GC17M042464 GC17M040217 GC17M040682 GC17M037562 GC17M036074


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNH4 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a
pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may
be involved in cellular excitability of restricted neurons in the central nervous system. (provided by RefSeq,
Jul 2008)

GeneCards Summary for KCNH4 Gene: 
KCNH4 (potassium voltage-gated channel, subfamily H (eag-related), member 4) is a protein-coding gene. Diseases associated with KCNH4 include campylobacteriosis, and neuronitis, and among its related super-pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include phosphorelay sensor kinase activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows
no inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH4 gene promoter:
         NRSF form 1   Tal-1beta   NRSF form 2   CREB   PPAR-gamma1   FOXJ2 (long isoform)   deltaCREB   ARP-1   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNH4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNH4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

KCNH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040308:  view genomic region     (about GC identifiers)

Start:
40,308,909 bp from pter      End:
40,333,296 bp from pter
Size:
24,388 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 4  
Size: 1017 amino acids; 111693 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for KCNH4: NX_Q9UQ05

Explore proteomics data for KCNH4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQ05

  • KCNH4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KCNH4 Protein Expression
    REFSEQ proteins: NP_036417.1  
    ENSEMBL proteins: 
     ENSP00000475564   ENSP00000264661  
    Reactome Protein details: Q9UQ05
    Human Recombinant Protein Products for KCNH4: 
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    Cloud-Clone Corp. Proteins for KCNH4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex TAS10455180
    GO:0016020membrane ----

    KCNH4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv12.3 
    Voltage-gated potassium channels

    5/9 InterPro protein domains (see all 9):
     IPR003950 K_chnl_volt-dep_ELK
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9UQ05

    ProtoNet protein and cluster: Q9UQ05

    5/6 Blocks protein domains (see all 6):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003950 ELK potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    KCNH4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNH4_HUMAN, Q9UQ05
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows
    no inactivation. Channel properties may be modulated by cAMP and subunit assembly

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0004871signal transducer activity ----
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity IBA--
    GO:0005515protein binding ----
         
    KCNH4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNH4:
     Synthetic lethal with Ras 

    Animal Models:
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    hsa-miR-596 hsa-miR-125a-5p hsa-miR-520a-5p hsa-miR-3150a-3p hsa-miR-23b* hsa-miR-661 hsa-miR-125b hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidKCNH4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KCNH4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Potassium transporters: outward current0.42
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KCNH4
        Potassium transporters- outward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNH4
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNH4
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNH4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for KCNH4 (ENSP000002646614) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA7ENSP000002214444STRING: ENSP00000221444
    KCNB1ENSP000003608064STRING: ENSP00000360806
    KCNC1ENSP000002659694STRING: ENSP00000265969
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000160phosphorelay signal transduction system ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS10455180
    GO:0007165signal transduction ----

    KCNH4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNH4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about KCNH4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KCNH4 gene: 
    NM_012285.2  

    Unigene Cluster for KCNH4:

    Potassium voltage-gated channel, subfamily H (eag-related), member 4
    Hs.304081  [show with all ESTs]
    Unigene Representative Sequence: NM_012285
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607371 ENST00000264661(uc002hzb.2)

    miRNA
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    hsa-miR-596 hsa-miR-125a-5p hsa-miR-520a-5p hsa-miR-3150a-3p hsa-miR-23b* hsa-miR-661 hsa-miR-125b hsa-miR-298
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    Additional mRNA sequence: AB022698.1 

    5 DOTS entries:

    DT.75138552  DT.75144132  DT.95093587  DT.75195626  DT.95146325 

    12 AceView cDNA sequences:

    BX091763 AB022698 NM_012285 BM549668 BX283895 BG758764 AI873041 BQ447844 
    AW084816 BE702920 AI932262 BM013212 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCACTCA
    KCNH4 Expression
    About this image


    See KCNH4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNH4

    SOURCE GeneReport for Unigene cluster: Hs.304081

    UniProtKB/Swiss-Prot: KCNH4_HUMAN, Q9UQ05
    Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate
    nucleus, and at lower levels in cerebral cortex, occipital and hippocampus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KCNH4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnh41 , 5 potassium voltage-gated channel, subfamily H (eag-related), more1, 5 87.35(n)1
    89.97(a)1
      11 (63.57 cM)5
    3807281  NM_001081194.21  NP_001074663.11 
     1007403765 
    chicken
    (Gallus gallus)
    Aves KCNH41 potassium voltage-gated channel, subfamily H (eag-related), more 71.93(n)
    71.05(a)
      772091  XM_001235279.2  XP_001235280.2 
    lizard
    (Anolis carolinensis)
    Reptilia KCNH46
    potassium voltage-gated channel, subfamily H (eag-...
    61(a)
    1 ↔ 1
    6(72778967-72849640)
    zebrafish
    (Danio rerio)
    Actinopterygii kcnh41 potassium voltage-gated channel, subfamily H (eag-related), more 66.67(n)
    66.59(a)
      100148126  XM_001920618.2  XP_001920653.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta elk3 potassium ion transport potassium
    channel
    52(a)     --


    ENSEMBL Gene Tree for KCNH4 (if available)
    TreeFam Gene Tree for KCNH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNH4 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  HCN22  CNGA22  CNGA12  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    6 SIMAP similar genes for KCNH4 using alignment to 1 protein entry:     KCNH4_HUMAN:
    KCNH8    KCNH3    KCNH5    KCNH6    KCNH2    KCNH1

    KCNH4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/600 SNPs in KCNH4 are shown (see all 600)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357714
    A colorectal cancer sample4--see VAR_0357712 G R mis40--------
    rs1407658851,2
    --40309354(+) AGCCTC/TCGCGC 1 -- int10--------
    rs1446163201,2
    C--40309358(+) TCCGCA/GCCTGG 1 -- int10--------
    rs1134036821,2
    F--40309630(+) TTTTTC/TGTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs780377091,2
    C,F--40309636(+) GTTTTG/ATTTTG 1 -- int11Minor allele frequency- A:0.04EA 120
    rs2017679851,2
    C--40309699(+) CTGCT-/CACTGC 1 -- int10--------
    rs1844187461,2
    --40309724(+) GGGCTC/TAAGAG 1 -- int10--------
    rs1895183221,2
    --40309897(+) CTGGAA/GTAGCT 1 -- int10--------
    rs1140431601,2
    C,F--40309898(+) TGGAGT/CAGCTG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1179524281,2
    F--40309926(+) CACTAC/TACCTG 1 -- int11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for KCNH4 (40308909 - 40333296 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNH4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908244CNV Loss21882294
    dgv3169n71CNV Loss21882294
    nsv908241CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604528    OMIM disorders: --

    3 diseases for KCNH4:    About MalaCards
    campylobacteriosis    neuronitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for KCNH4:
    Campylobacteriosis

    KCNH4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): KCNH4
    Human Genome Epidemiology (HuGE) Navigator: KCNH4 (3 documents)

    Export disorders for KCNH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNH4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with KCNH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)1, 2, 3, 9 Miyake A.... Furuichi K. (1999)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    4. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)1, 9 Zou A.... Wickenden A.D. (2003)
    5. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. (PubMed id 11050086)9 Vanhoutte P....Caboche J. (2001)
    8. A neurotoxic phosphoform of Elk-1 associates with inc lusions from multiple neurodegenerative diseases. (PubMed id 20126313)9 Sharma A....Eberwine J. (2010)
    9. Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients. (PubMed id 10891039)9 Kyosseva S.V....Karson C.N. (2000)
    10. Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation. (PubMed id 19390590)9 Gokce O....Luthi-Carter R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23415 HGNC: 6253 AceView: KCNH4 Ensembl:ENSG00000089558 euGenes: HUgn23415
    ECgene: KCNH4 H-InvDB: KCNH4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KCNH4 gene:
    Search GeneIP for patents involving KCNH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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