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Aliases & Descriptions for KCNH3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BEC1 1, 2, 3, 5 | | ELK2 2, 3 | | KIAA1282 2, 3 | | Kv12.2 1, 2 | | elk2 1 |
| | | Descriptions |
|---|
| Brain-specific eag-like channel 1 3 | | ELK channel 2 3 | | Ether-a-go-go-like potassium channel 2 3 | | Voltage-gated potassium channel subunit Kv12.2 3 | | ether-a-go-go K(+) channel family member 2 | potassium voltage-gated channel, subfamily H (eag-related), member 3 2 |
|
| | Search outside databases for aliases for KCNH3 genePrevious GC identifers: GC12P050150 GC12P049989 GC12P049649 |
Summaries for KCNH3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly |
Genomic Location for KCNH3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNH3 gene 
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13KCNH3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P048219:
(about GC identifiers)
Start:
|
48,219,207 bp from pter |
End:
|
48,238,344 bp from pter |
Size:
|
19,138 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for KCNH3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily H member 3 Size: 1083 amino acids; 117129 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9UQ06REFSEQ proteins: NP_036416.1
ENSEMBL proteins: ENSP00000257981
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNH3: Assays for KCNH3: | Protein
Domains/ Families for KCNH3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9ULD8
ProtoNet protein and cluster: Q9ULD8 5/6 Blocks protein families (see all 6
): IPB000014 PAS domain IPB000595 Cyclic nucleotide-binding domain IPB001610 PAC motif IPB003938 EAG/ELK/ERG potassium channel family signature IPB003950 ELK potassium channel family signature
UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. H (Eag) subfamilySimilarity: Contains 1 cyclic nucleotide-binding domainSimilarity: Contains 1 PAC (PAS-associated C-terminal) domainSimilarity: Contains 1 PAS (PER-ARNT-SIM) domain | Gene Function for KCNH3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_035483
Applied Biosystems Silencer® siRNAs for KCNH3
Sigma-Aldrich siRNA and siRNA Panels for KCNH3  Sigma-Aldrich shRNA Panels and shRNA for KCNH3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012284                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012284                                  untagged cDNA clone in CMV expression vector: NM_012284 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012284
UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assemblyGenatlas biochemistry entry for KCNH3:potassium voltage-gated channel,subfamily H (eag-related),member 3,ether-a-go-go K+ channel family member,exclusively expressed in the brain,mainly in the cerebral cortex,amygdala,hippocampus and striatum4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KCNH3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNH3 
5 Interacting proteins for KCNH3 (ENSP000002579813) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000160 | two-component signal transduction system (phosphorelay) |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
TAS | 10455180 | About this table
|
Drugs & Compounds for KCNH3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for KCNH3 |
Compounds for KCNH3 available from Tocris Bioscience About this table
|
Transcripts for KCNH3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_035483
Sigma-Aldrich siRNA and siRNA Panels for KCNH3  Sigma-Aldrich shRNA Panels and shRNA for KCNH3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012284 REFSEQ mRNAs for KCNH3 gene: NM_012284.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012284               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012284                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012284                                  untagged cDNA clone in CMV expression vector: NM_012284  Additional cDNA sequence: AB022696.1 AB033108.1 BC033141.1 BC144254.1 BC150602.1 1 DOTS entry: DT.403685 24/39 AceView cDNA sequences (see all 39
):CA433932 AW248878 BM452074 AI272282 NM_012284 BX095172 BC033141 AB033108 AB022696 CD106245 BU187340 AI017220 BG060031 BQ045257 AW082228 BV185837 AI124750 AI627894 BE778330 AW249035 BE795800 AI873733 U69184 M79045
highest scoring ESTs for KCNH3:AB022696 AB033108 AI124750 AI627894 AI873733 AW248597 AW248878 AW249035 AW251056 AW518396 Unigene Cluster for KCNH3: Potassium voltage-gated channel, subfamily H (eag-related), member 3 Hs.64064 [show with all ESTs]Unigene Representative Sequence: NM_012284
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for KCNH3
1 Ensembl transcript including schematic representation: ENST00000257981
|
Expression for KCNH3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNH3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNH3
1 / 2 / 3 3 probe-sets matching KCNH3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.64064 UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus |
Orthologs for KCNH3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNH3 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNH31 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
89.57(n) 92.69(a) |
486556 XM_543682.2 XP_543682.2 |
chimpanzee (Pan troglodytes) |
KCNH31 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
99.63(n) 99.72(a) |
451880 XM_509046.2 XP_509046.2 |
cow (Bos taurus) |
KCNH31 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
92.3(n) 95.9(a) |
514409 XM_592255.3 XP_592255.3 |
rat (Rattus norvegicus) |
Kcnh31 |
-- |
potassium voltage-gated channel, subfamily H (eag-related), more |
89.32(n) 95.94(a) |
27150 NM_017108.1 NP_058804.1 |
mouse (Mus musculus) |
Kcnh31, 5 |
155
|
potassium voltage-gated channel, subfamily H (eag-related), more1, 5 |
89.72(n)1 95.84(a)1 |
165121 NM_010601.21 NP_034731.21 AF1091435 AK1350935 (see all 10) |
About this table Species with no ortholog for KCNH3
ENSEMBL Gene Tree for KCNH3 | Paralogs for KCNH3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNH3 gene
- KCNH42 KCNH82
|
SNPs/Variants for KCNH3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNH3 (up to first 250kb)
|
Disorders & Mutations for KCNH3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604527
|
Medical News for KCNH3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNH3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for KCNH3 gene: |
Search for KCNH3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNH3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNH3
(According to HUGE)
About This Section
| |
Specialized Databases showing KCNH3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNH3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNH3:

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|
 |  |  |
| | | | Tocris compounds for KCNH3 |
|
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Incremental update: 13 Oct 2009
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