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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNH3 Gene

protein-coding   GIFtS: 56
GCID: GC12P049933

potassium voltage-gated channel, subfamily H (eag-related),...
 Explore 2 diseases affiliated with
KCNH3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNH3    

Aliases
for KCNH3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 31 2     ELK22 3
BEC11 2 3 5     ELK Channel 22 3
Kv12.21 2     Elk21
Brain-Specific Eag-Like Channel 12 3     Ether-A-Go-Go K(+) Channel Family Member2
Ether-A-Go-Go-Like Potassium Channel 22 3     Potassium Voltage-Gated Channel Subfamily H Member 32
Voltage-Gated Potassium Channel Subunit Kv12.22 3     KIAA12823

External Ids:    HGNC: 62521   Entrez Gene: 234162   Ensembl: ENSG000001355197   OMIM: 6045275   UniProtKB: Q9ULD83   

Export aliases for KCNH3 gene to outside databases

Previous GC identifers: GC12P050150 GC12P049989 GC12P049649 GC12P048219 GC12P046963


Summaries
for KCNH3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH3:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH3


Genomic Views
for KCNH3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

KCNH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049933:  view genomic region     (about GC identifiers)

Start:
 49,932,940 bp from pter      End:
 49,952,077 bp from pter
Size:
 19,138 bases      Orientation:
 plus strand

Proteins
for KCNH3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 3  
Size: 1083 amino acids; 117129 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA86596.1; Type=Erroneous initiation;
Secondary accessions: Q9UQ06

Explore the universe of human proteins at neXtProt for KCNH3: NX_Q9ULD8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULD8

    • KCNH3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036416.1  
    ENSEMBL proteins: 
     ENSP00000257981  
    Reactome Protein details: Q9ULD8
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNH3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS10455180


    KCNH3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KCNH3

    Protein Domains /
    Families
    for KCNH3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNH3 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR003950 K_chnl_volt-dep_ELK
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9ULD8

    ProtoNet protein and cluster: Q9ULD8

    5/6 Blocks protein families (see all 6):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003950 ELK potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Function
    for KCNH3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
    inactivation. Channel properties may be modulated by cAMP and subunit assembly

         Genatlas biochemistry entry for KCNH3:
    potassium voltage-gated channel,subfamily H (eag-related),member 3,ether-a-go-go K+ channel family member,exclusively
    expressed in the brain,mainly in the cerebral cortex,amygdala,hippocampus and striatum

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNH3 (see all 10):
    hsa-miR-3163 hsa-miR-596 hsa-miR-3678-3p hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-922 hsa-miR-125b hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: KCNH3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0005249voltage-gated potassium channel activity TAS10455180


    KCNH3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNH3:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for KCNH3: Kcnh3tm1Akmi Kcnh3tm1.2Tije
         2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnh3):
     behavior/neurological  nervous system 

    KCNH3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KCNH3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium Channels
    		Potassium Channels1.00
    		Voltage gated Potassium channels0.43
    2Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    3Transmission across Chemical Synapses
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNH3
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    3        Reactome Pathways for KCNH3
        Potassium Channels
    Neuronal System
    Voltage gated Potassium channels



    KCNH3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for KCNH3 (Q9ULD82 ENSP000002579814) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA4ENSP000003285114STRING: ENSP00000328511
    KCNA7ENSP000002214444STRING: ENSP00000221444
    KCNAB2ENSP000001642474STRING: ENSP00000164247
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006813potassium ion transport TAS10455180
    GO:0007268synaptic transmission TAS--


    KCNH3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNH3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]

    1 HMDB Compound for KCNH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Search CenterWatch for drugs/clinical trials and news about KCNH3 

    Transcripts
    for KCNH3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNH3 gene: 
    NM_012284.1  

    Unigene Cluster for KCNH3:

    Potassium voltage-gated channel, subfamily H (eag-related), member 3
    Hs.64064  [show with all ESTs]
    Unigene Representative Sequence: NM_012284
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257981(uc001ruh.1 uc010smj.1) ENST00000550434 ENST00000551415
    ENST00000548675

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNH3 (see all 10):
    hsa-miR-3163 hsa-miR-596 hsa-miR-3678-3p hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-922 hsa-miR-125b hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: KCNH3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNH3 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB022696.1 AB033108.1 BC033141.1 BC144254.1 BC150602.1 

    1 DOTS entry:

    DT.403685 

    24/39 AceView cDNA sequences (see all 39):

    BC033141 AB022696 AB033108 CD106245 AW248878 AI272282 NM_012284 BM452074 
    BX095172 CA433932 AW251056 AW082228 AI873733 BE795800 BV185837 BE266788 
    AW249035 M79045 BQ045257 AI627894 AL134774 BG060031 U69184 AI124750 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                            -                                                               
    SP2:                                                                                                            
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for KCNH3

    Expression
    for KCNH3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNH3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNH3

    SOURCE GeneReport for Unigene cluster: Hs.64064

    UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
    Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex,
    occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus

        SABiosciences Expression via Pathway-Focused PCR Array including KCNH3: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for KCNH3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNH3 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia KCNH36
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343198.1(2028159-2052814)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000066141 potassium voltage-gated channel subfamily H member more 60.33(n)
    59.06(a)    		   100006614  XM_001919401.2  XP_001919436.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta elk3 potassium ion transport potassium channel 48(a)     --


    ENSEMBL Gene Tree for KCNH3 (if available)
    TreeFam Gene Tree for KCNH3 (if available) 

    Paralogs
    for KCNH3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNH3 gene
    KCNH62  KCNH52  HCN32  HCN42  HCN22  KCNH42  CNGA22  CNGA12  
    HCN12  KCNH72  KCNH22  CNGB12  CNGA42  CNGA32  CNGB32  KCNH12  
    KCNH82  
    6 SIMAP similar genes for KCNH3 using alignment to 2 protein entries:     KCNH3_HUMAN (see all proteins):
    KCNH8    KCNH4    KCNH1    KCNH5    KCNH2    KCNH6

    KCNH3 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNH3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/322 NCBI SNPs in KCNH3 are shown (see all 322)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1408571611,2
    		--49930993(+) TCTACC/TAAAAA 1 -- us2k10--------
    rs1447278351,2
    		--49931084(+) TTGGTC/GGGCAT 1 -- us2k10--------
    rs38633901,2
    		A--49931154(+) ccgtcA/Ccaaaa 1 -- us2k10--------
    rs1906493441,2
    		--49931456(+) CCTCAG/TGGTCA 1 -- us2k10--------
    rs111690631,2
    		C,F,A,H,--49931585(+) GCTGAT/CGAGGG 1 -- us2k122Minor allele frequency- C:0.37NS EA NA WA CSA 2353
    rs767110011,2
    		F,--49931625(+) AGTGCG/ATCTCG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs116131831,2
    		C,F,H,--49931730(+) CTCGCT/CGGCAA 1 -- us2k13Minor allele frequency- C:0.36NA WA 126
    rs11500561,2
    		C,F,A,H,--49931867(-) TGCCCG/TGGGGC 1 -- us2k16Minor allele frequency- T:0.02NA WA EA 250
    rs1478901471,2
    		--49932053(+) GGAGAA/GGCAAG 1 -- us2k10--------
    rs1818680031,2
    		--49932256(+) CCAGAG/TCGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNH3 (49932940 - 49952077 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KCNH3: --

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    Disorders / Diseases
    for KCNH3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNH3 for disorders           About GeneDecksing

    OMIM gene information: 604527    OMIM disorders: --

    2 diseases for KCNH3:    About MalaCards
    cerebritis    immunodeficiency


    Export disorders for KCNH3 gene to outside databases

    Publications
    for KCNH3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNH3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCNH3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)1, 2, 3, 9 Miyake A.... Furuichi K. (1999)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    4. Interaction of human immunodeficiency virus gp120 wit h the voltage-gated potassium channel BEC1. (PubMed id 20638388)1 Herrmann M....Mueller-Lantzsch N. (2010)
    5. Disruption of the ether-a-go-go K+ channel gene BEC1/ KCNH3 enhances cognitive function. (PubMed id 19923296)1 Miyake A....Katou M. (2009)
    6. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)1 Zou A.... Wickenden A.D. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. (PubMed id 11893742)9 Smith G.A....Schlichter L.C. (2002)

    External Searches for KCNH3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNH3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23416 HGNC: 6252 AceView: KCNH3 Ensembl:ENSG00000135519 euGenes: HUgn23416
    ECgene: KCNH3 H-InvDB: KCNH3

    Other Databases showing KCNH3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1282

    Specialized Databases showing KCNH3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNH3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNH3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNH3 gene:
    Search GeneIP for patents involving KCNH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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