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KCNH3 Gene

protein-coding   GIFtS: 59
GCID: GC12P049933

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related),...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member
31 2
     ELK Channel 22 3
BEC12 3 5     Kv12.22
Brain-Specific Eag-Like Channel 12 3     Ether-A-Go-Go K(+) Channel Family Member2
Ether-A-Go-Go-Like Potassium Channel 22 3     Potassium Voltage-Gated Channel Subfamily H Member 32
Voltage-Gated Potassium Channel Subunit Kv12.22 3     KIAA12823
ELK22 3     

External Ids:    HGNC: 62521   Entrez Gene: 234162   Ensembl: ENSG000001355197   OMIM: 6045275   UniProtKB: Q9ULD83   

Export aliases for KCNH3 gene to outside databases

Previous GC identifers: GC12P050150 GC12P049989 GC12P049649 GC12P048219 GC12P046963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KCNH3 Gene:
KCNH3 (potassium voltage-gated channel, subfamily H (eag-related), member 3) is a protein-coding gene. GO annotations related to this gene include phosphorelay sensor kinase activity and voltage-gated potassium channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH3 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNH3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNH3 promoter sequence
   Search Chromatin IP Primers for KCNH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

KCNH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049933:  view genomic region     (about GC identifiers)

Start:
49,932,940 bp from pter      End:
49,952,091 bp from pter
Size:
19,152 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 3  
Size: 1083 amino acids; 117129 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits
Sequence caution: Sequence=BAA86596.1; Type=Erroneous initiation;
Secondary accessions: Q9UQ06

Explore the universe of human proteins at neXtProt for KCNH3: NX_Q9ULD8

Explore proteomics data for KCNH3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn421, Asn428, Asn436

  • See KCNH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036416.1  
    ENSEMBL proteins: 
     ENSP00000257981  
    Reactome Protein details: Q9ULD8

    KCNH3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv12.2
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR003950 K_chnl_volt-dep_ELK
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q9ULD8

    ProtoNet protein and cluster: Q9ULD8

    Selected Blocks protein domains (see all 6):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003950 ELK potassium channel family signature


    UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    Find genes that share domains with KCNH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNH3_HUMAN, Q9ULD8
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
    inactivation. Channel properties may be modulated by cAMP and subunit assembly

         Genatlas biochemistry entry for KCNH3:
    potassium voltage-gated channel,subfamily H (eag-related),member 3,ether-a-go-go K+ channel family
    member,exclusively expressed in the brain,mainly in the cerebral cortex,amygdala,hippocampus and striatum

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155phosphorelay sensor kinase activity IEA--
    GO:0004871signal transducer activity ----
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity TAS10455180
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with KCNH3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNH3:
     Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Kcnh3):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with KCNH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KCNH3: Kcnh3tm1Akmi Kcnh3tm1.2Tije Kcnh3tm1(KOMP)Vlcg

       genOway: Develop your customized and physiologically relevant rodent model for KCNH3

    miRNA
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    miRTarBase miRNAs that target KCNH3:
    hsa-mir-335-5p (MIRT016741)

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    Selected qRT-PCR Assays for microRNAs that regulate KCNH3 (see all 10):
    hsa-miR-3163 hsa-miR-596 hsa-miR-3678-3p hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-922 hsa-miR-125b hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidKCNH3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNH3_HUMAN, Q9ULD8: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IBA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS10455180

    Find genes that share ontologies with KCNH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Find genes that share SuperPaths with KCNH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNH3
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNH3
        Voltage gated Potassium channels


        Pathway & Disease-focused RT2 Profiler PCR Array including KCNH3: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KCNH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNH3 (Q9ULD81, 2 ENSP000002579814) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA4ENSP000003285114STRING: ENSP00000328511
    KCNA7ENSP000002214444STRING: ENSP00000221444
    KCNAB2ENSP000001642474STRING: ENSP00000164247
    KCNAB3ENSP000003027194STRING: ENSP00000302719
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000160phosphorelay signal transduction system ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006811ion transport ----
    GO:0006813potassium ion transport TAS10455180
    GO:0007165signal transduction ----

    Find genes that share ontologies with KCNH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNH3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

    1 HMDB Compound for KCNH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 IUPHAR Ligand for KCNH3 (Kv12.2)    About this table
    LigandTypeActionAffinityPubmed IDs
    Cs+
    Pore BlockerNone1.212193184



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNH3 gene: 
    NM_012284.1  

    Unigene Cluster for KCNH3:

    Potassium voltage-gated channel, subfamily H (eag-related), member 3
    Hs.64064  [show with all ESTs]
    Unigene Representative Sequence: NM_012284
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257981(uc001ruh.1 uc010smj.1) ENST00000550434 ENST00000551415
    ENST00000548675
    miRNA
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    Additional mRNA sequence: 

    AB022696.1 AB033108.1 BC033141.1 BC144254.1 BC150602.1 

    1 DOTS entry:

    DT.403685 

    Selected AceView cDNA sequences (see all 39):

    AI272282 AW248878 AB022696 AB033108 CA433932 BM452074 BX095172 NM_012284 
    BC033141 CD106245 AI627894 BG060031 AW082228 AL134774 AI017220 AW518396 
    AI124750 BV185837 AW251056 BE266788 BE778330 BE646495 BE795800 BU187340 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                            -                                                               
    SP2:                                                                                                            
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for KCNH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNH3 Expression
    About this image


    KCNH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    KCNH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.64064

    UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
    Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex,
    occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus

        Pathway & Disease-focused RT2 Profiler PCR Array including KCNH3: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KCNH3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcnh31 , 5 potassium voltage-gated channel, subfamily H (eag-related), more1, 5 89.6(n)1
    95.57(a)1
      15 (56.08 cM)5
    165121  NM_010601.31  NP_034731.31 
     992249765 
    lizard
    (Anolis carolinensis)
    Reptilia KCNH36
    potassium voltage-gated channel, subfamily H (eag-...
    68(a)
    1 ↔ 1
    GL343198.1(2028159-2119290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004922371 potassium voltage-gated channel subfamily H member more 61.54(n)
    63.36(a)
      100492237  XM_002940721.2  XP_002940767.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000066141 potassium voltage-gated channel subfamily H member more 63.85(n)
    62.8(a)
      100006614  XM_001919401.3  XP_001919436.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta elk3 potassium ion transport potassium
    channel
    48(a)     --


    ENSEMBL Gene Tree for KCNH3 (if available)
    TreeFam Gene Tree for KCNH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNH3 gene
    KCNH62  KCNH52  HCN32  HCN42  KCNH42  HCN22  CNGA12  CNGA22  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    6 SIMAP similar genes for KCNH3 using alignment to 2 protein entries:     KCNH3_HUMAN (see all proteins):
    KCNH8    KCNH4    KCNH2    KCNH1    KCNH5    KCNH6

    Find genes that share paralogs with KCNH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNH3 (see all 467)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408571611,2
    --49930993(+) TCTACC/TAAAAA 1 -- us2k10--------
    rs1447278351,2
    C--49931084(+) TTGGTC/GGGCAT 1 -- us2k10--------
    rs38633901,2
    A--49931154(+) ccgtcA/Ccaaaa 1 -- us2k10--------
    rs3759115061,2
    C--49931181(+) AAAAA-/TTCAC 
     ACAGACC
    AAAAT
    1 -- us2k10--------
    rs1906493441,2
    --49931456(+) CCTCAG/TGGTCA 1 -- us2k10--------
    rs111690631,2
    C,F,A,H--49931585(+) GCTGAT/CGAGGG 1 -- us2k122Minor allele frequency- C:0.37NS EA NA WA CSA 2353
    rs767110011,2
    C,F--49931625(+) AGTGCG/ATCTCG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs116131831,2
    C,F,H--49931730(+) CTCGCT/CGGCAA 1 -- us2k13Minor allele frequency- C:0.36NA WA 126
    rs11500561,2
    C,F,A,H--49931867(-) TGCCCG/TGGGGC 1 -- us2k16Minor allele frequency- T:0.02NA WA EA 250
    rs1478901471,2
    --49932053(+) GGAGAA/GGCAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNH3 (49932940 - 49952091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KCNH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899071CNV Loss21882294
    nsv832406CNV Loss17160897
    nsv899070CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNH3
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604527    OMIM disorders: --


    Find genes that share disorders with KCNH3           About GenesLikeMe

    Genetic Association Database (GAD): KCNH3

    Export disorders for KCNH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNH3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KCNH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)1, 2, 3, 9 Miyake A.... Furuichi K. (J. Biol. Chem. 1999)
    2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    4. Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. (PubMed id 20638388)1 Herrmann M....Mueller-Lantzsch N. (FEBS Lett. 2010)
    5. Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function. (PubMed id 19923296)1 Miyake A....Katou M. (J. Neurosci. 2009)
    6. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)1 Zou A.... Wickenden A.D. (Am. J. Physiol. 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. (PubMed id 11893742)9 Smith G.A....Schlichter L.C. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23416 HGNC: 6252 AceView: KCNH3 Ensembl:ENSG00000135519 euGenes: HUgn23416
    ECgene: KCNH3 H-InvDB: KCNH3

    (According to HUGE)
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    HUGE: KIAA1282

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNH3 gene:
    Search GeneIP for patents involving KCNH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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