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KCNH1 Gene

protein-coding GIFtS: 62

GC01M208923

potassium voltage-gated channel, subfamily H (eag-related), member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EAG ^², ³, ⁵
EAG1 ^², ³
Kv10.1 ^¹, ²
MGC142269 ^²
OTTHUMP00000034451 ^²
OTTHUMP00000034569 ^²
eag ^¹
eag1 ^¹
h-eag ^¹, ², ³
hEAG1 ^³

Descriptions
Ether-a-go-go potassium channel 1 ^², ³
Voltage-gated potassium channel subunit Kv10.1 ^³
ether-a-go-go, Drosophila, homolog of ^²
potassium channel, voltage-gated, subfamily H, member 1 ^²
potassium voltage-gated channel, subfamily H (eag-related), member 1 ^²
potassium voltage-gated channel, subfamily H, member 1 ^²

External Ids
HGNC: 6250¹
Entrez Gene: 3756²
UniProtKB: O95259³
Ensembl: ENSG00000143473⁷

Search outside databases for aliases for KCNH1 gene

Previous GC identifers: GC01M209587 GC01M206691 GC01M207495 GC01M207935 GC01M207244

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNH1:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

channels from both functional and structural standpoints. Their diverse functions include

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,

epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a

member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha)

subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated

at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts.

Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell

proliferation. Alternative splicing of this gene results in two transcript variants encoding

distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259

Function: Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier

potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates

IK(NI) current in myoblasts

Gene Wiki entry for KCNH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNH1 gene

Entrez Gene cytogenetic band: 1q32-q41 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.2

KCNH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M208923: (about GC identifiers)

Start:	208,923,178 bp from pter
End:	209,374,080 bp from pter
Size:	450,903 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily H member 1

Size: 989 amino acids; 111423 Da

Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of

pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with

KCNH5/EAG2. Interacts with ALG10B (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O76035

Alternative splicing: 2 isoforms: O95259-1 O95259-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002229.1 NP_758872.1

ENSEMBL proteins:

ENSP00000271751 ENSP00000355974

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (KCNH1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	9738473
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNH1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNH1
	Sigma-Aldrich Antibodies for KCNH1
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (KCNH1)
	Novus Biologicals Antibody for KCNH1

Assays for KCNH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95259

ProtoNet protein and cluster: O95259

5/6 Blocks protein families (see all 6 ):

IPB000014 PAS domain

IPB000595 Cyclic nucleotide-binding domain

IPB001610 PAC motif

IPB003938 EAG/ELK/ERG potassium channel family signature

IPB003949 EAG potassium channel signature

UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of

positively charged amino acids at every third position

Similarity: Belongs to the potassium channel family. H (Eag) subfamily

Similarity: Contains 1 cyclic nucleotide-binding domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172362

Applied Biosystems Silencer® siRNAs for KCNH1

Sigma-Aldrich siRNA and siRNA Panels for KCNH1

Sigma-Aldrich shRNA Panels and shRNA for KCNH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002238
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002238
untagged cDNA clones in CMV expression vector (see all 2): NM_002238

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_172362

UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259

Function: Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier

potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates

IK(NI) current in myoblasts

Genatlas biochemistry entry for KCNH1:

potassium voltage-gated channel,Drosophila ether-a-go-go (eag)-related subfamily H,expressed in

myoblasts at the onset of fusion and in adult brain tissue,similar to the non-inactivating delayed

rectified potassium channel (I(K(NI))

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000155	two-component sensor activity	IEA	--
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005251	delayed rectifier potassium channel activity	TAS	9738473
GO:0005516	calmodulin binding	IEA	--
GO:0030955	potassium ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KCNH1

5/46 Interacting proteins for KCNH1 (ENSP00000271751³) via UniProtKB, MINT, and/or STRING (see all 46 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNE1	ENSP00000337255³	STRING (score=.974)
KCNC1	ENSP00000265969³	STRING (score=.968)
KCNA3	ENSP00000358784³	STRING (score=.962)
KCNQ1	ENSP00000370153³	STRING (score=.959)
KCNQ2	ENSP00000359244³	STRING (score=.959)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000160	two-component signal transduction system (phosphorelay)	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	9738473
GO:0007520	myoblast fusion	TAS	9738473

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for KCNH1

Sigma-Aldrich Small Molecules for KCNH1:

Antagonist

Compounds for KCNH1 available from Tocris Bioscience

Compound	Action	CAS number
Chromanol 293B	IKs blocker. Also blocks ICFTR	[163163-23-3]
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
(-)-[3R,4S]-Chromanol 293B	IKs blocker. Enantiomer of (Cat. No. 1412)	[163163-24-4]
4-Aminopyridine	K+ channel blocker	[504-24-5]

About this table

1 Novoseek chemical compound relationship for KCNH1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	63.87	13	9490815 (2), 10880439 (1), 16478480 (1), 8938715 (1) (see all 8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172362

Sigma-Aldrich siRNA and siRNA Panels for KCNH1

Sigma-Aldrich shRNA Panels and shRNA for KCNH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002238 NM_172362

REFSEQ mRNAs for KCNH1 gene (2 alternative transcripts):

NM_002238.3 NM_172362.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002238 NM_172362

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002238
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002238
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002238

Additional cDNA sequence:

AJ001366.1 AK127526.1 BC113709.1 BC143599.1

4 DOTS entries:

DT.95103014 DT.91753863 DT.100008058 DT.455175

5 AceView cDNA sequences:

NM_002238 AJ001366 NM_172362 AF078741 AF078742

highest scoring ESTs for KCNH1:

AF078742 AJ001366 AF078741 BF949480 NM_002238 NM_172362 AA435647 DB021985 AA393900 AA908907

Unigene Cluster for KCNH1:

Potassium voltage-gated channel, subfamily H (eag-related), member 1

Hs.553187 [show with all ESTs]

Unigene Representative Sequence: NM_172362

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:															-
SP2:

About this scheme

ECgene alternative splicing isoforms for KCNH1

2 Ensembl transcripts including schematic representations:

ENST00000271751 ENST00000367007

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNH1

¹ / ² / ³

4 probe-sets matching KCNH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33088_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.10	AF078742	1.00	0.90	0.95	1
33087_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	2.05	AJ001366	1.00	0.90	0.95	1
207635_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002238	0.60	1.00	0.82	1
207635_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.553187
Expression variation in blood from EXPOLDB for KCNH1
UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259
Tissue specificity: Highly expressed in brain and in myoblasts at the onset of fusion, but not in
other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7
(epithelial tumor) cells, but not in normal epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNH1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNH1¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	87.56(n) 91.27(a)	490277 XM_547397.2 XP_547397.2
chimpanzee (Pan troglodytes)	KCNH1¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	99(n) 98.86(a)	745653 XM_001169423.1 XP_001169423.1
cow (Bos taurus)	KCNH1¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	91.18(n) 96.98(a)	281881 NM_174372.2 NP_776797.1
rat (Rattus norvegicus)	Kcnh1¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	88.32(n) 97.71(a)	65198 NM_031742.1 NP_113930.1
mouse (Mus musculus)	Kcnh1^{1, 5}	1⁵	potassium voltage-gated channel, subfamily H (eag-related), more^{1, 5}	88.67(n)¹ 96.99(a)¹	16510¹ NM_001038607.1¹ NP_001033696.1¹ AA547351⁵ AK047694⁵ (see all 12)

About this table Species with no ortholog for KCNH1

ENSEMBL Gene Tree for KCNH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNH1 gene

KCNH5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2529 NCBI SNPs in KCNH1 are shown (see all 2529 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 665)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11119568^1,2	A,C,F,H	208919131(+)	`CACAGG/CAGCTG`	2	--	ut3¹		4	EU EA WA	416
	rs6680517^1,2	A,C,F,H	208921438(+)	`CCCTTG/AAGCTC`	2	--	ut3¹		7	EU EA WA NA	558
--	rs11119680^1,2	A,C,F,H	209375826(+)	`GCTTAG/CATAAA`	2	--	ng3¹ tfbs³		4	EU EA WA	420
	rs11119569^1,2	A,C,F,H	208920972(+)	`GTGCCG/AGACAA`	2	--	ut3¹		5	EU WA NA	354
	rs12126648^1,2	A,C,F,H	208922743(+)	`AGTTAC/TAAATG`	2	--	ut3¹		11	EU EA WA NA	978
	rs1890841^1,2	A,C,F,O	208922474(+)	`CAGCCG/AGGCAC`	2	--	ut3¹		7	NA EA	498
	rs3135473^1,2	C,F,H	208923208(-)	`TACCTA/CCAACC`	2	--	ut3¹ ese³		12	EA NA EU WA	2380
	rs12126038^1,2	C,F,H	208919605(+)	`GGAGAG/TGAAGC`	2	--	ut3¹		7	EU EA WA NA	562
	rs3811395^1,2	C,F,H	209374739(+)	`AGGGCG/AAATGC`	2	--	ng3¹ tfbs³		5	EA EU WA	1906
	rs17260634^1,2	F,H	208918804(+)	`ATCCGT/CCGGAT`	2	--	ut3¹		7	NA EU EA WA	562

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HapMap Linkage Disequilibrium images for KCNH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603305

UniProtKB/Swiss-Prot: KCNH1_HUMAN, O95259

Overexpression of EAG may confer a growth advantage to cancer cells and favor tumor cell

proliferation

1 Novoseek disease relationship for KCNH1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	2	19351862 (1), 15365094 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for KCNH1 gene (see all 38 ):

Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. (PubMed id 9738473)^{1, 2, 3, 4} Occhiodoro T.... Fischer-Lougheed J. (1998)
Inhibition of human ether a go-go potassium channels by Ca(2+)/calmodulin. (PubMed id 10880439)^{1, 3, 4} Schoenherr R.... Heinemann S.H. (2000)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{2, 3} Gutman G.A....Wang X. (2005)
Functional distinction of human EAG1 and EAG2 potassium channels. (PubMed id 11943152)^{3, 4} Schoenherr R.... Heinemann S.H. (2002)
Oncogenic potential of EAG K(+) channels. (PubMed id 10523298)^{3, 4} Pardo L.A.... Stuehmer W. (1999)
Ether a go-go potassium channel expression in soft tissue sarcoma patients. (PubMed id 17022811)^{1, 3} Mello de Queiroz F....Pardo L.A. (2006)
Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. (PubMed id 16478480)^{1, 3} Ziechner U....Heinemann S.H. (2006)
Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. (PubMed id 18650019)^{1, 3} Martin S....Del Bel E. (2008)
Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells. (PubMed id 18222922)³ Spitzner M....Kunzelmann K. (2008)
Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. (PubMed id 18927085)³ Downie B.R....Pardo L.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3756	HGNC: 6250	AceView: KCNH1	Ensembl:ENSG00000143473	euGenes: HUgn3756
ECgene: KCNH1	H-InvDB: KCNH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KCNH1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KCNH1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNH1		Antibodies for KCNH1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNH1		Small molecules for KCNH1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KCNH1)
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Tocris compounds for KCNH1

	Drugs for KCNH1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for KCNH1

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KCNH1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for KCNH1

Summaries
for KCNH1

Genomic Location
for KCNH1

Proteins
for KCNH1

Protein Domains/
Families
for KCNH1

Gene Function
for KCNH1

Pathways & Interactions
for KCNH1

Drugs & Compounds
for KCNH1

Transcripts
for KCNH1

Expression
for KCNH1

Orthologs
for KCNH1

Paralogs
for KCNH1

SNPs/Variants
for KCNH1

Disorders & Mutations
for KCNH1

Medical News
for KCNH1

Publications
for KCNH1

Search for KCNH1

Genome Databases showing KCNH1

Other Databases showing KCNH1

Specialized Databases showing KCNH1

Licensable Technologies
for KCNH1

Services
for KCNH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNH1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor KCNH1

Summariesfor KCNH1

Genomic Locationfor KCNH1

Proteinsfor KCNH1

Protein Domains/Familiesfor KCNH1

Gene Functionfor KCNH1

Pathways & Interactionsfor KCNH1

Drugs & Compoundsfor KCNH1

Transcriptsfor KCNH1

Expression for KCNH1

Orthologsfor KCNH1

Paralogsfor KCNH1

SNPs/Variantsfor KCNH1

Disorders & Mutationsfor KCNH1

Medical Newsfor KCNH1

Publicationsfor KCNH1

Search for KCNH1

Genome Databases showing KCNH1

Other Databases showing KCNH1

Specialized Databases showing KCNH1

Licensable Technologiesfor KCNH1

Servicesfor KCNH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNH1

Summaries
for KCNH1

Genomic Location
for KCNH1

Proteins
for KCNH1

Protein Domains/
Families
for KCNH1

Gene Function
for KCNH1

Pathways & Interactions
for KCNH1

Drugs & Compounds
for KCNH1

Transcripts
for KCNH1

Expression
for KCNH1

Orthologs
for KCNH1

Paralogs
for KCNH1

SNPs/Variants
for KCNH1

Disorders & Mutations
for KCNH1

Medical News
for KCNH1

Publications
for KCNH1

Licensable Technologies
for KCNH1

Services
for KCNH1