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KCNG4 Gene(Protein Coding)

Potassium Voltage-Gated Channel Modifier Subfamily G Member 4

GCID:
GC16M084255
GIFtS:
50
Genes Participants
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Aliases for KCNG4 Gene

Aliases for KCNG4 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily G Member 4 2 3
  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 4 3 5
  • Potassium Voltage-Gated Channel, Subfamily G, Member 4 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.4 3 4
  • Voltage-Gated Potassium Channel Kv6.3 3
  • KV6.3 3
  • KV6.4 3
  • KCNG3 4

External Ids for KCNG4 Gene

Previous GeneCards Identifiers for KCNG4 Gene

  • GC16M085222
  • GC16M083994
  • GC16M084035
  • GC16M082813
  • GC16M070009

Summaries for KCNG4 Gene

Entrez Gene Summary for KCNG4 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG4 Gene

KCNG4 (Potassium Voltage-Gated Channel Modifier Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.

UniProtKB/Swiss-Prot for KCNG4 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Tocris Summary for KCNG4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNG4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG4 Gene

Genomics for KCNG4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for KCNG4 Gene

Enhancers for KCNG4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNG4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KCNG4 gene promoter:

Genomic Location for KCNG4 Gene

Chromosome:
16
Start:
84,218,667 bp from pter
End:
84,239,750 bp from pter
Size:
21,084 bases
Orientation:
Minus strand

Genomic View for KCNG4 Gene

Genes around KCNG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNG4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KCNG4 Gene

Proteins for KCNG4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KCNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN1-KCNG4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 4
    Protein Accession:
    Q8TDN1
    Secondary Accessions:
    • Q96H24

    Protein attributes for KCNG4 Gene

    Size:
    519 amino acids
    Molecular mass:
    58979 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:19074135).

    Alternative splice isoforms for KCNG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG4 Gene

Proteomics data for KCNG4 Gene at MOPED

Post-translational modifications for KCNG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG4 Gene

Domains & Families for KCNG4 Gene

Gene Families for KCNG4 Gene

HGNC:
IUPHAR :

Protein Domains for KCNG4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDN1

UniProtKB/Swiss-Prot:

KCNG4_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.
genes like me logo Genes that share domains with KCNG4: view

Function for KCNG4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for KCNG4 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Phenotypes for KCNG4 Gene

GenomeRNAi human phenotypes for KCNG4:
genes like me logo Genes that share phenotypes with KCNG4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNG4

miRNA for KCNG4 Gene

miRTarBase miRNAs that target KCNG4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNG4 Gene

Localization for KCNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG4 Gene

Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:19074135). {ECO:0000269 PubMed:19074135}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNG4 Gene COMPARTMENTS Subcellular localization image for KCNG4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNG4: view

Pathways & Interactions for KCNG4 Gene

genes like me logo Genes that share pathways with KCNG4: view

Pathways by source for KCNG4 Gene

1 Qiagen pathway for KCNG4 Gene

Gene Ontology (GO) - Biological Process for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IDA 19074135
genes like me logo Genes that share ontologies with KCNG4: view

No data available for SIGNOR curated interactions for KCNG4 Gene

Drugs & Compounds for KCNG4 Gene

Products:

  1. Drug

(1) Drugs for KCNG4 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNG4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNG4 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNG4: view

Transcripts for KCNG4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KCNG4 Gene

(2) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG4 Gene

No ASD Table

Relevant External Links for KCNG4 Gene

GeneLoc Exon Structure for
KCNG4
ECgene alternative splicing isoforms for
KCNG4

Expression for KCNG4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for KCNG4 Gene

mRNA expression in normal human tissues for KCNG4 Gene
mRNA expression by BioGPS for KCNG4 GenemRNA expression by GTEx for KCNG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG4 Gene

This gene is overexpressed in Brain - Substantia nigra (x6.5), Brain - Amygdala (x5.4), Brain - Hippocampus (x4.9), Brain - Hypothalamus (x4.8), and Brain - Putamen (basal ganglia) (x4.1).

SOURCE GeneReport for Unigene cluster for KCNG4 Gene Hs.335877

mRNA Expression by UniProt/SwissProt for KCNG4 Gene

Q8TDN1-KCNG4_HUMAN
Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and colon.
genes like me logo Genes that share expression patterns with KCNG4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNG4 Gene

Orthologs for KCNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia KCNG4 35
  • 86.67 (n)
  • 85.74 (a)
KCNG4 36
  • 86 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia KCNG4 35
  • 85.48 (n)
  • 82.57 (a)
KCNG4 36
  • 82 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Kcng4 35
  • 82.34 (n)
  • 82.87 (a)
Kcng4 16
Kcng4 36
  • 82 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia KCNG4 35
  • 98.78 (n)
  • 98.65 (a)
KCNG4 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Kcng4 35
  • 82.27 (n)
  • 82.67 (a)
oppossum
(Monodelphis domestica)
 Mammalia KCNG4 36
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KCNG4 36
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KCNG4 35
  • 68.19 (n)
  • 72.56 (a)
CKV6.3 36
  • 71 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia KCNG4 36
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia kcng4 35
  • 63.97 (n)
  • 68.28 (a)
zebrafish
(Danio rerio)
 Actinopterygii kcng4a 35
  • 68.04 (n)
  • 68.26 (a)
KCNG4 (1 of 2) 36
  • 52 (a)
 OneToMany
kcng4a 36
  • 56 (a)
 OneToMany
Species with no ortholog for KCNG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG4 Gene

ENSEMBL:
Gene Tree for KCNG4 (if available)
TreeFam:
Gene Tree for KCNG4 (if available)

Paralogs for KCNG4 Gene

Paralogs for KCNG4 Gene

(16) SIMAP similar genes for KCNG4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNG4: view

Variants for KCNG4 Gene

Sequence variations from dbSNP and Humsavar for KCNG4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs35379218 - 84,237,464(-) GAGAC(A/C/G/T)GGGGC reference, missense
rs11646443 - 84,236,870(+) CAGCC(A/G)GTTCA reference, missense
rs17736370 - 84,223,013(+) GAGAG(C/T)ATTCG reference, missense
rs4782905 - 84,222,816(+) CCTCT(C/T)GCCGT reference, missense
rs7196482 - 84,222,804(+) GCTCC(C/T)GCTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KCNG4 Gene

Variant ID Type Subtype PubMed ID
nsv833309 CNV Loss 17160897
nsv907063 CNV Loss 21882294
nsv833310 CNV Loss 17160897
esv2672151 CNV Deletion 23128226
nsv907064 CNV Loss 21882294

Variation tolerance for KCNG4 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.17; 98.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCNG4 Gene

Disorders for KCNG4 Gene

Relevant External Links for KCNG4

Genetic Association Database (GAD)
KCNG4
Human Genome Epidemiology (HuGE) Navigator
KCNG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNG4

No disorders were found for KCNG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNG4 Gene

Publications for KCNG4 Gene

  1. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PMID: 12060745) Ottschytsch N. … Snyders D.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 67
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for KCNG4 Gene

Sources for KCNG4 Gene

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