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KCNG4 Gene(Protein Coding)

Potassium Voltage-Gated Channel Modifier Subfamily G Member 4

GCID:
GC16M084255
GIFtS:
42
Genes Participants
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Aliases for KCNG4 Gene

Aliases for KCNG4 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily G Member 4 2 3 5
  • Potassium Voltage-Gated Channel, Subfamily G, Member 4 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.4 3 4
  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 4 3
  • Potassium Voltage-Gated Channel Subfamily G Member 4 3
  • Voltage-Gated Potassium Channel Kv6.3 3
  • KV6.3 3
  • KV6.4 3
  • KCNG3 4

External Ids for KCNG4 Gene

Previous GeneCards Identifiers for KCNG4 Gene

  • GC16M085222
  • GC16M083994
  • GC16M084035
  • GC16M082813
  • GC16M070009

Summaries for KCNG4 Gene

Entrez Gene Summary for KCNG4 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG4 Gene

KCNG4 (Potassium Voltage-Gated Channel Modifier Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNG1.

UniProtKB/Swiss-Prot for KCNG4 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Tocris Summary for KCNG4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNG4 Gene

Additional gene information for KCNG4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG4 Gene

Genomics for KCNG4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KCNG4 Gene

Promoters and enhancers for KCNG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16I084239 Enhancer 0.3 Ensembl 550.8 +0.1 149 0.4 CTCF KCNG4 PIR45029
GH16I084367 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.2 -129.8 -129803 3.8 CLOCK FOXA2 NFIB NEUROD1 SIN3A RFX5 ZNF121 ZNF143 FOS RCOR1 ATP2C2 KCNG4 GC16P084460
GH16I084266 Enhancer 0.9 ENCODE 11.9 -26.8 -26830 0.2 PKNOX1 ATF1 MLX ARID4B ZNF76 FEZF1 ETS1 ZNF143 FOS CREM WFDC1 KCNG4 NECAB2 GC16M084262 RNA5SP433 LOC105376777
GH16I084044 Enhancer 0.9 ENCODE dbSUPER 10.4 +195.4 195399 0.2 SOX13 CTCF ESRRA NFATC3 ARID4B RAD21 RARA SMC3 NR2F6 ZNF444 SLC38A8 TAF1C NECAB2 OSGIN1 ADAD2 DNAAF1 HSDL1 KCNG4 ENSG00000274677
GH16I084396 Enhancer 0.7 ENCODE 10.9 -157.0 -157000 0.2 FOXA2 SIN3A CEBPG CTBP1 GATA3 FOSL2 ZNF444 FOS TCF7L2 SMARCE1 KCNG4 ATP2C2 GC16P084460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNG4 gene promoter:

Genomic Locations for KCNG4 Gene

Genomic Locations for KCNG4 Gene
chr16:84,218,667-84,239,750
(GRCh38/hg38)
Size:
21,084 bases
Orientation:
Minus strand
chr16:84,254,741-84,273,356
(GRCh37/hg19)

Genomic View for KCNG4 Gene

Genes around KCNG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNG4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KCNG4 Gene

Proteins for KCNG4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KCNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN1-KCNG4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 4
    Protein Accession:
    Q8TDN1
    Secondary Accessions:
    • Q96H24

    Protein attributes for KCNG4 Gene

    Size:
    519 amino acids
    Molecular mass:
    58979 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:19074135).

    Alternative splice isoforms for KCNG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG4 Gene

Post-translational modifications for KCNG4 Gene

No Post-translational modifications

Other Protein References for KCNG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG4 Gene

Domains & Families for KCNG4 Gene

Gene Families for KCNG4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Voltage-gated ion channels

Protein Domains for KCNG4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDN1

UniProtKB/Swiss-Prot:

KCNG4_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.
genes like me logo Genes that share domains with KCNG4: view

Function for KCNG4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for KCNG4 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Phenotypes From GWAS Catalog for KCNG4 Gene

Gene Ontology (GO) - Molecular Function for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005251 delayed rectifier potassium channel activity IDA 19074135
GO:0005267 potassium channel activity IEA --
GO:0044325 ion channel binding IPI 19074135
genes like me logo Genes that share ontologies with KCNG4: view
genes like me logo Genes that share phenotypes with KCNG4: view

Animal Model Products

CRISPR Products

miRNA for KCNG4 Gene

miRTarBase miRNAs that target KCNG4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNG4 Gene

Localization for KCNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG4 Gene

Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:19074135). {ECO:0000269 PubMed:19074135}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNG4 gene
Compartment Confidence
plasma membrane 5
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 colocalizes_with voltage-gated potassium channel complex IDA 19074135
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNG4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNG4 Gene

Pathways & Interactions for KCNG4 Gene

genes like me logo Genes that share pathways with KCNG4: view

Pathways by source for KCNG4 Gene

1 Qiagen pathway for KCNG4 Gene

Gene Ontology (GO) - Biological Process for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNG4: view

No data available for SIGNOR curated interactions for KCNG4 Gene

Drugs & Compounds for KCNG4 Gene

Products:

  1. Drug

(4) Drugs for KCNG4 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KCNG4 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for KCNG4 Gene

Compound Action Cas Number
Chromanol 293B IKs blocker. Also blocks ICFTR 163163-23-3
Flupirtine maleate KV7 channel activator 75507-68-5
Kaliotoxin KV and KCa blocker 145199-73-1
MaxiPost Potassium channel modulator; exerts subtype-specific effects 187523-35-9
genes like me logo Genes that share compounds with KCNG4: view

Transcripts for KCNG4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KCNG4 Gene

(2) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG4 Gene

No ASD Table

Relevant External Links for KCNG4 Gene

GeneLoc Exon Structure for
KCNG4
ECgene alternative splicing isoforms for
KCNG4

Expression for KCNG4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNG4 Gene

mRNA expression in normal human tissues for KCNG4 Gene
mRNA expression by GTEx for KCNG4 GenemRNA expression by BioGPS for KCNG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG4 Gene

This gene is overexpressed in Brain - Substantia nigra (x6.5), Brain - Amygdala (x5.4), Brain - Hippocampus (x4.9), Brain - Hypothalamus (x4.8), and Brain - Putamen (basal ganglia) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of KCNG4 Gene:

KCNG4

SOURCE GeneReport for Unigene cluster for KCNG4 Gene:

Hs.335877

mRNA Expression by UniProt/SwissProt for KCNG4 Gene:

Q8TDN1-KCNG4_HUMAN
Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Evidence on tissue expression from TISSUES for KCNG4 Gene

  • Muscle(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KCNG4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNG4 Gene

Orthologs for KCNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KCNG4 33 34
  • 98.78 (n)
cow
(Bos Taurus)
 Mammalia KCNG4 33 34
  • 86.67 (n)
dog
(Canis familiaris)
 Mammalia KCNG4 33 34
  • 85.48 (n)
mouse
(Mus musculus)
 Mammalia Kcng4 33 16 34
  • 82.34 (n)
rat
(Rattus norvegicus)
 Mammalia Kcng4 33
  • 82.27 (n)
oppossum
(Monodelphis domestica)
 Mammalia KCNG4 34
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KCNG4 34
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CKV6.3 34
  • 71 (a)
 OneToOne
KCNG4 33
  • 68.19 (n)
lizard
(Anolis carolinensis)
 Reptilia KCNG4 34
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia kcng4 33
  • 63.97 (n)
zebrafish
(Danio rerio)
 Actinopterygii kcng4a 33 34
  • 68.04 (n)
KCNG4 (1 of 2) 34
  • 52 (a)
 OneToMany
Species where no ortholog for KCNG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG4 Gene

ENSEMBL:
Gene Tree for KCNG4 (if available)
TreeFam:
Gene Tree for KCNG4 (if available)

Paralogs for KCNG4 Gene

Paralogs for KCNG4 Gene

(16) SIMAP similar genes for KCNG4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNG4: view

Variants for KCNG4 Gene

Sequence variations from dbSNP and Humsavar for KCNG4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000012795 -- 84,238,881(-) C/A intron_variant
rs1000016728 -- 84,226,772(-) G/A/C intron_variant
rs1000106886 -- 84,228,495(-) C/T intron_variant
rs1000118187 -- 84,228,591(-) C/T intron_variant
rs1000206938 -- 84,240,863(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNG4 Gene

Variant ID Type Subtype PubMed ID
esv2672151 CNV deletion 23128226
esv2761930 CNV gain 21179565
esv3639412 CNV loss 21293372
esv3639413 CNV loss 21293372
esv3639414 CNV loss 21293372
esv3639415 CNV loss 21293372
nsv1059227 CNV loss 25217958
nsv1065790 CNV loss 25217958
nsv1111143 CNV tandem duplication 24896259
nsv483044 CNV gain 15286789
nsv833309 CNV loss 17160897
nsv833310 CNV loss 17160897

Variation tolerance for KCNG4 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.17; 98.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNG4 Gene

Disorders for KCNG4 Gene

Additional Disease Information for KCNG4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCNG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNG4 Gene

Publications for KCNG4 Gene

  1. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PMID: 12060745) Ottschytsch N … Snyders DJ (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PMID: 19074135) Mederos Y Schnitzler M … Preisig-Müller R (The Journal of biological chemistry 2009) 3 4 58
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KCNG4 Gene

Sources for KCNG4 Gene

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