KCNG4 Gene

Aliases
for KCNG4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC16M085222 GC16M083994 GC16M084035 GC16M082813 GC16M070009

Summaries
for KCNG4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for KCNG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NC_018927.2  NT_010498.16  

SwitchGear Promoter luciferase reporter plasmid: KCNG4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNG4

KCNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084255:  view genomic region     (about GC identifiers)

Proteins
for KCNG4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for KCNG4: NX_Q8TDN1

Explore proteomics data for KCNG4 at MOPED

Post-translational modifications: 

KCNG4 Human Recombinant Protein Products:

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	antibodies-online peptides for KCNG4

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Domains /
Families
for KCNG4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8TDN1

Find genes that share domains with KCNG4           About GenesLikeMe

Function
for KCNG4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for KCNG4

miRNA Products:		miRTarBase miRNAs that target KCNG4: hsa-mir-101-3p (MIRT027271), hsa-mir-103a-3p (MIRT027010), hsa-mir-16-5p (MIRT031572)
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		Predesigned siRNA for gene silencing in human, mouse, rat KCNG4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for KCNG4

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG4

Localization
for KCNG4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	1
nucleus	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for KCNG4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for KCNG4 About     See pathways by source

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	SuperPath	Contained pathways About
1	Potassium Channels	Potassium Channels 0.43 Voltage gated Potassium channels 0.43
2	Transmission across Chemical Synapses	Neuronal System 0.68
3	Dopamine-DARPP32 Feedback onto cAMP Pathway	Dopamine-DARPP32 Feedback onto cAMP Pathway

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNG4

Dopamine-DARPP32 Feedback onto cAMP Pathway

1 Reactome Pathway for KCNG4

Voltage gated Potassium channels

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for KCNG4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for KCNG4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for KCNG4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KCNG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGATTTAAGA

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Brain (Nervous System)    fully expand to see all 7 entries
Thalamus
Midbrain

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG4

Orthologs
for KCNG4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for KCNG4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for KCNG4 gene

KCNF1²  KCNG3²  KCNB2²  KCNV1²  KCNG2²  KCNS2²  KCNS3²  KCNB1²  

KCNV2²  KCNG1²  KCNS1²  

16 SIMAP similar genes for KCNG4 using alignment to 3 protein entries:     KCNG4_HUMAN (see all proteins):

KCNG1    KCNG2    KCNB1    KCNB2    KCNG3    KCNS2

KCNF1    KCNS3    KCNV1    KCND1    KCNS1    KCNV2

KCND3    KCNC2    KCND2    KCNA1

Find genes that share paralogs with KCNG4           About GenesLikeMe

Genomic Variants
for KCNG4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KCNG4 (see all 731)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1821215061,2		--	84254243(+)	TGATCA/TTGTGC	1	--	ds5001		0	--	--	--	--
rs71848101,2	H	--	84254283(+)	CAAACT/CCCTAT	1	--	ds5001		4		NS EA	412
rs395531,2	C,F,H	--	84254287(+)	CTCCTG/ATGTGG	1	--	ds5001		29		EA NA NS WA CSA	2571
rs1853312001,2		--	84254294(+)	GTGGGC/TCATGC	1	--	ds5001		0	--	--	--	--
rs1881354491,2		--	84254366(+)	TTGACA/GGAATC	1	--	ds5001		0	--	--	--	--
rs395521,2	C,F,O,H	--	84254384(+)	ATTAAA/GCCCGT	1	--	ds5001		39		NA PA NS EA WA CSA	3524
rs1439102771,2		--	84254400(+)	AGGGAA/GGGCTG	1	--	ds5001		0	--	--	--	--
rs1813306771,2		--	84254437(+)	TCATCC/TCAAAC	1	--	ds5001		0	--	--	--	--
rs1138863361,2	C,F	--	84254454(+)	TCTCAC/TGCCCA	1	--	ds5001		2		CSA	3
rs1402331531,2		--	84254505(+)	TCACTC/TTGCCC	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNG4 (84254741 - 84273356 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for KCNG4:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2672151	CNV	Deletion	23128226
nsv907063	CNV	Loss	21882294
nsv833309	CNV	Loss	17160897
nsv833310	CNV	Loss	17160897
nsv907064	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KCNG4

DNA2.0 Custom Variant and Variant Library Synthesis for KCNG4

Disorders / Diseases
for KCNG4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for KCNG4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745)^{1, 2, 3} Ottschytsch N.... Snyders D.J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (PLoS Genet. 2012)
6. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PubMed id 19074135)¹ Mederos Y Schnitzler M.... Preisig-Muller R. (J. Biol. Chem. 2009)
7. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. (PubMed id 19717558)¹ Bocksteins E....Snyders D.J. (J. Biol. Chem. 2009)
8. Domain analysis of Kv6.3, an electrically silent channel. (PubMed id 16096342)¹ Ottschytsch N....Snyders D.J. (J. Physiol. (Lond.) 2005)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

External Searches for KCNG4 gene

Genome Databases showing KCNG4 gene

Other Databases showing KCNG4 gene

Specialized Databases showing KCNG4 gene

Products
for KCNG4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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