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KCNG4 Gene

protein-coding   GIFtS: 57
GCID: GC16M084255

Potassium Voltage-Gated Channel, Subfamily G, Member 4
  See related diseases
at
MalaCards
 

Aliases
for KCNG4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Subfamily G, Member 41 2     Potassium Voltage-Gated Channel Subfamily G Member 42
Voltage-Gated Potassium Channel Subunit Kv6.42 3     Voltage-Gated Potassium Channel Kv6.32
KV6.32 5     KCNG33
KV6.42 5     

External Ids:    HGNC: 196971   Entrez Gene: 931072   Ensembl: ENSG000001684187   OMIM: 6076035   UniProtKB: Q8TDN13   

Export aliases for KCNG4 gene to outside databases

Previous GC identifers: GC16M085222 GC16M083994 GC16M084035 GC16M082813 GC16M070009


Summaries
for KCNG4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNG4 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member
functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced
variants have been found in normal and cancerous tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNG4 Gene:
KCNG4 (potassium voltage-gated channel, subfamily G, member 4) is a protein-coding gene. Diseases associated with KCNG4 include fainting, and neuronitis. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal
activation to more negative values

summary for KCNG4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG4 Gene


Genomic Views
for KCNG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNG4 gene promoter:
         ER-alpha   HEN1   S8   E2F   E2F-1   HOXA5   SEF-1 (1)   AP-4   ATF   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNG4 promoter sequence
   Search Chromatin IP Primers for KCNG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

KCNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNG4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084255:  view genomic region     (about GC identifiers)

Start:
 84,254,741 bp from pter      End:
 84,273,356 bp from pter
Size:
 18,616 bases      Orientation:
 minus strand

Proteins
for KCNG4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 4  
Size: 519 amino acids; 58979 Da
Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Secondary accessions: Q96H24
Alternative splicing: 2 isoforms:  Q8TDN1-1   Q8TDN1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNG4: NX_Q8TDN1

Explore proteomics data for KCNG4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See KCNG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_758857.1  
    ENSEMBL proteins: 
     ENSP00000312129   ENSP00000457897  
    Reactome Protein details: Q8TDN1

    KCNG4 Human Recombinant Protein Products:

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    KCNG4 Assay Products:

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    Cloud-Clone Corp. CLIAs for KCNG4

    Domains /
    Families
    for KCNG4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv6.4
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027359 Channel_four-helix_dom
     IPR003971 K_chnl_volt-dep_Kv9

    Graphical View of Domain Structure for InterPro Entry Q8TDN1

    ProtoNet protein and cluster: Q8TDN1

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003969 Kv6 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily


    KCNG4 for domains           About GeneDecksing


    Function
    for KCNG4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNG4_HUMAN, Q8TDN1
    Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal
    activation to more negative values

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
         
    KCNG4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNG4:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNG4
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    miRNA
    Products:            		miRTarBase miRNAs that target KCNG4:
    hsa-mir-101-3p (MIRT027271), hsa-mir-103a-3p (MIRT027010), hsa-mir-16-5p (MIRT031572)

    Block miRNA regulation of human, mouse, rat KCNG4 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmid: KCNG4 3' UTR sequence
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    Gene Editing
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    In Situ Assay
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    Localization
    for KCNG4 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNG4_HUMAN, Q8TDN1: Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly
    another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----

    KCNG4 for ontologies           About GeneDecksing


    Pathways & Interactions
    for KCNG4 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNG4 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    		Potassium Channels0.43
    		Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    		Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNG4
        Dopamine-DARPP32 Feedback onto cAMP Pathway


    1 Reactome Pathway for KCNG4
        Voltage gated Potassium channels



    KCNG4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNG4
    Interactions:

        Search GeneGlobe Interaction Network for KCNG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNG4 (Q8TDN13 ENSP000003121294) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNB1Q147213, ENSP000003608064I2D: score=1 STRING: ENSP00000360806
    KCNF1Q9H3M03, ENSP000002950824I2D: score=1 STRING: ENSP00000295082
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    KCNG4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNG4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNG4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]



    Transcripts
    for KCNG4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KCNG4 gene (2 alternative transcripts): 
    NM_172347.2  NM_133490.2  

    Unigene Clusters for KCNG4:

    Potassium voltage-gated channel, subfamily G, member 4
    Hs.335877  [show with all ESTs], Hs.560407
    Unigene Representative Sequences: BC008969, NM_172347
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308251(uc010voc.2) ENST00000568181(uc002fhu.1)
    miRNA
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    Additional mRNA sequence: 

    AF348984.1 AF450108.1 BC109203.2 

    2 DOTS entries:

    DT.97821050  DT.86844971 

    9 AceView cDNA sequences:

    BC008969 NM_172347 AF450108 NM_133490 AF348984 AW409885 AW409623 BE270322 
    BE298461 

    GeneLoc Exon Structure


    Expression
    for KCNG4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    KCNG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATTTAAGA
    KCNG4 Expression
    About this image


    KCNG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             Midbrain   
    KCNG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    KCNG4 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.335877 Hs.560407

    UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
    Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and colon

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    In Situ
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    Orthologs
    for KCNG4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNG4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kcng41 , 5 potassium voltage-gated channel, subfamily G, member 4 less1, 5 82.34(n)1
    82.87(a)1    		   8 (68.07 cM)5
    667331  NM_025734.21  NP_080010.21 
     1196238545 
    chicken
    (Gallus gallus)    		 Aves KCNG41 potassium voltage-gated channel, subfamily G, member 4 less 68.19(n)
    72.56(a)    		   395901  XM_425129.3  XP_425129.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNG46
    		 potassium voltage-gated channel, subfamily G, memb...
    		 69(a)
    		 1 ↔ 1
    		 GL343849.1(96540-116852)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia kcng41 potassium voltage-gated channel, subfamily G, member 4 less 63.97(n)
    68.28(a)    		   100497160  XM_002934951.2  XP_002934997.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii kcng4a1 potassium voltage-gated channel, subfamily G, member 4a less 68.04(n)
    68.26(a)    		   561003  NM_001110029.1  NP_001103499.1 


    ENSEMBL Gene Tree for KCNG4 (if available)
    TreeFam Gene Tree for KCNG4 (if available)

    Paralogs
    for KCNG4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNG4 gene
    KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS22  KCNS32  KCNB12  
    KCNV22  KCNG12  KCNS12  
    16 SIMAP similar genes for KCNG4 using alignment to 3 protein entries:     KCNG4_HUMAN (see all proteins):
    KCNG1    KCNG2    KCNB1    KCNB2    KCNG3    KCNS2
    KCNF1    KCNS3    KCNV1    KCND1    KCNS1    KCNV2
    KCND3    KCNC2    KCND2    KCNA1

    KCNG4 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNG4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNG4 (see all 731)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1821215061,2
    		--84254243(+) TGATCA/TTGTGC 1 -- ds50010--------
    rs71848101,2
    		H--84254283(+) CAAACT/CCCTAT 1 -- ds50014Minor allele frequency- C:0.00NS EA 412
    rs395531,2
    		C,F,H--84254287(+) CTCCTG/ATGTGG 1 -- ds500129Minor allele frequency- A:0.27EA NA NS WA CSA 2571
    rs1853312001,2
    		--84254294(+) GTGGGC/TCATGC 1 -- ds50010--------
    rs1881354491,2
    		--84254366(+) TTGACA/GGAATC 1 -- ds50010--------
    rs395521,2
    		C,F,O,H--84254384(+) ATTAAA/GCCCGT 1 -- ds500139Minor allele frequency- G:0.29NA PA NS EA WA CSA 3524
    rs1439102771,2
    		--84254400(+) AGGGAA/GGGCTG 1 -- ds50010--------
    rs1813306771,2
    		--84254437(+) TCATCC/TCAAAC 1 -- ds50010--------
    rs1138863361,2
    		C,F--84254454(+) TCTCAC/TGCCCA 1 -- ds50012Minor allele frequency- T:0.33CSA 3
    rs1402331531,2
    		--84254505(+) TCACTC/TTGCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KCNG4 (84254741 - 84273356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672151CNV Deletion23128226
    nsv907063CNV Loss21882294
    nsv833309CNV Loss17160897
    nsv833310CNV Loss17160897
    nsv907064CNV Loss21882294

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    Disorders / Diseases
    for KCNG4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607603    OMIM disorders: --

    2 diseases for KCNG4:    
    About MalaCards
    fainting    neuronitis


    KCNG4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KCNG4
    Human Genome Epidemiology (HuGE) Navigator: KCNG4 (1 document)

    Export disorders for KCNG4 gene to outside databases

    Publications
    for KCNG4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNG4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with KCNG4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745)1, 2, 3 Ottschytsch N.... Snyders D.J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PubMed id 19074135)1 Mederos Y Schnitzler M.... Preisig-Muller R. (J. Biol. Chem. 2009)
    7. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. (PubMed id 19717558)1 Bocksteins E....Snyders D.J. (J. Biol. Chem. 2009)
    8. Domain analysis of Kv6.3, an electrically silent channel. (PubMed id 16096342)1 Ottschytsch N....Snyders D.J. (J. Physiol. (Lond.) 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    External Searches for KCNG4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    Genome Databases showing KCNG4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 93107 HGNC: 19697 AceView: KCNG4 Ensembl:ENSG00000168418 euGenes: HUgn93107
    ECgene: KCNG4 H-InvDB: KCNG4

    Other Databases showing KCNG4 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing KCNG4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNG4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNG4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for KCNG4 gene:
    Search GeneIP for patents involving KCNG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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