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Aliases for KCNG4 Gene

Aliases for KCNG4 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 4 2 3
  • Potassium Voltage-Gated Channel, Subfamily G, Member 4 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.4 3 4
  • KV6.3 3 6
  • KV6.4 3 6
  • Potassium Voltage-Gated Channel Subfamily G Member 4 3
  • Voltage-Gated Potassium Channel Kv6.3 3
  • KCNG3 4

External Ids for KCNG4 Gene

Summaries for KCNG4 Gene

Entrez Gene Summary for KCNG4 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG4 Gene

KCNG4 (Potassium Channel, Voltage Gated Modifier Subfamily G, Member 4) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNG4 Gene

  • Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values

Tocris Summary for KCNG4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG4 Gene

Genomics for KCNG4 Gene

Genomic Location for KCNG4 Gene

Start:
84,218,667 bp from pter
End:
84,239,750 bp from pter
Size:
21,084 bases
Orientation:
Minus strand

Genomic View for KCNG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG4 Gene

Regulatory Elements for KCNG4 Gene

Proteins for KCNG4 Gene

  • Protein details for KCNG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN1-KCNG4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 4
    Protein Accession:
    Q8TDN1
    Secondary Accessions:
    • Q96H24

    Protein attributes for KCNG4 Gene

    Size:
    519 amino acids
    Molecular mass:
    58979 Da
    Quaternary structure:
    • Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers

    Alternative splice isoforms for KCNG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG4 Gene

Proteomics data for KCNG4 Gene at MOPED

Post-translational modifications for KCNG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNG4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG4 Gene

Domains for KCNG4 Gene

Gene Families for KCNG4 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q8TDN1

UniProtKB/Swiss-Prot:

KCNG4_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q8TDN1
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily.:
    • Q8TDN1
genes like me logo Genes that share domains with KCNG4: view

Function for KCNG4 Gene

Molecular function for KCNG4 Gene

UniProtKB/Swiss-Prot Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values

Gene Ontology (GO) - Molecular Function for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
genes like me logo Genes that share ontologies with KCNG4: view

Phenotypes for KCNG4 Gene

GenomeRNAi human phenotypes for KCNG4:
genes like me logo Genes that share phenotypes with KCNG4: view

miRNA for KCNG4 Gene

miRTarBase miRNAs that target KCNG4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNG4 Gene

Localization for KCNG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG4 Gene

Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNG4 Gene COMPARTMENTS Subcellular localization image for KCNG4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNG4: view

Pathways for KCNG4 Gene

genes like me logo Genes that share pathways with KCNG4: view

Pathways by source for KCNG4 Gene

1 Qiagen pathway for KCNG4 Gene

Gene Ontology (GO) - Biological Process for KCNG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCNG4: view

Compounds for KCNG4 Gene

(5) Tocris Compounds for KCNG4 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
genes like me logo Genes that share compounds with KCNG4: view

Transcripts for KCNG4 Gene

mRNA/cDNA for KCNG4 Gene

(2) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG4 Gene

No ASD Table

Relevant External Links for KCNG4 Gene

GeneLoc Exon Structure for
KCNG4
ECgene alternative splicing isoforms for
KCNG4

Expression for KCNG4 Gene

mRNA expression in normal human tissues for KCNG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG4 Gene

This gene is overexpressed in Brain - Substantia nigra (6.5), Brain - Amygdala (5.4), Brain - Hippocampus (4.9), Brain - Hypothalamus (4.8), and Brain - Putamen (basal ganglia) (4.1).

SOURCE GeneReport for Unigene cluster for KCNG4 Gene Hs.335877

mRNA Expression by UniProt/SwissProt for KCNG4 Gene

Q8TDN1-KCNG4_HUMAN
Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and colon
genes like me logo Genes that share expressions with KCNG4: view

No data available for Protein expression for KCNG4 Gene

Orthologs for KCNG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNG4 35
  • 98.78 (n)
  • 98.65 (a)
KCNG4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNG4 35
  • 86.67 (n)
  • 85.74 (a)
KCNG4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNG4 35
  • 85.48 (n)
  • 82.57 (a)
KCNG4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcng4 35
  • 82.34 (n)
  • 82.87 (a)
Kcng4 16
Kcng4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNG4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNG4 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcng4 35
  • 82.27 (n)
  • 82.67 (a)
chicken
(Gallus gallus)
Aves CKV6.3 36
  • 71 (a)
OneToOne
KCNG4 35
  • 68.19 (n)
  • 72.56 (a)
lizard
(Anolis carolinensis)
Reptilia KCNG4 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcng4 35
  • 63.97 (n)
  • 68.28 (a)
zebrafish
(Danio rerio)
Actinopterygii KCNG4 (1 of 2) 36
  • 52 (a)
OneToMany
kcng4a 35
  • 68.04 (n)
  • 68.26 (a)
kcng4a 36
  • 56 (a)
OneToMany
Species with no ortholog for KCNG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG4 Gene

ENSEMBL:
Gene Tree for KCNG4 (if available)
TreeFam:
Gene Tree for KCNG4 (if available)

Paralogs for KCNG4 Gene

Paralogs for KCNG4 Gene

Selected SIMAP similar genes for KCNG4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNG4: view

Variants for KCNG4 Gene

Sequence variations from dbSNP and Humsavar for KCNG4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs39549 -- 84,221,510(+) AGGTC(A/C/G)CAGAT utr-variant-3-prime
rs39550 -- 84,221,240(+) ACCTA(C/T)AATTC utr-variant-3-prime
rs39551 -- 84,221,205(+) GAGAT(A/G)ACTAG utr-variant-3-prime
rs39552 -- 84,220,778(+) ATTAA(A/G)CCCGT downstream-variant-500B
rs39553 -- 84,220,681(+) CTCCT(A/G)TGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KCNG4 Gene

Variant ID Type Subtype PubMed ID
nsv833309 CNV Loss 17160897
nsv907063 CNV Loss 21882294
nsv833310 CNV Loss 17160897
esv2672151 CNV Deletion 23128226
nsv907064 CNV Loss 21882294

Relevant External Links for KCNG4 Gene

HapMap Linkage Disequilibrium report
KCNG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNG4 Gene

Disorders for KCNG4 Gene

Relevant External Links for KCNG4

Genetic Association Database (GAD)
KCNG4
Human Genome Epidemiology (HuGE) Navigator
KCNG4
genes like me logo Genes that share disorders with KCNG4: view

No data available for UniProtKB/Swiss-Prot for KCNG4 Gene

Publications for KCNG4 Gene

  1. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PMID: 12060745) Ottschytsch N. … Snyders D.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for KCNG4 Gene

Sources for KCNG4 Gene

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