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Aliases & Descriptions for KCNG4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KCNG3 3 KV6.3 2 , 5 KV6.4 2 , 5 Kv6.4 1 MGC129609 2 MGC4558 2
Descriptions Voltage-gated potassium channel subunit Kv6.4 3 potassium voltage-gated channel, subfamily G, member 4 2 potassium voltage-gated channel, subfamily G, member 4, isoform 1 2 voltage-gated potassium channel Kv6.3 2
Search outside databases for aliases for KCNG4 genePrevious GC identifers: GC16M085222 GC16M083994 GC16M084035
Summaries for KCNG4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for KCNG4 : Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ionchannels from both functional and structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes amember of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatorysubunit. The gene has strong expression in brain. Multiple alternatively spliced variants havebeen found in normal and cancerous tissues. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 Function : Potassium channel subunit. Modulates channel activity by shifting the threshold and thehalf-maximal activation to more negative values
Genomic Location for KCNG4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the KCNG4 gene Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1 KCNG4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M082813:
(about GC identifiers )
Start:
82,813,324 bp from pter
End:
82,830,857 bp from pter
Size:
17,534 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000016.8 NT_010498.15 Proteins for KCNG4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 (See
protein sequence )Recommended Name: Potassium voltage-gated channel subfamily G member 4 Size : 519 amino acids; 58979 Da
Subunit : Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Subcellular location : Cell membrane; Multi-pass membrane protein. Note=Has to be associated withKCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular inthe absence of KCNB1
Secondary accessions : Q96H24Alternative splicing : 2 isoforms : Q8TDN1-1 Q8TDN1-2
REFSEQ proteins (2 alternative transcripts):
NP_597997.1 NP_758857.1 ENSEMBL proteins: ENSP00000312129 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0008076 voltage-gated potassium channel complex
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for KCNG4: Assays for KCNG4:
Protein
Domains/ Families for KCNG4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8TDN1 ProtoNet protein and cluster: Q8TDN1
3 Blocks protein families : IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003969 Kv6 potassium channel alpha subunit signature UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 Domain : The segment S4 is probably the voltage-sensor and is characterized by a series ofpositively charged amino acids at every third position Similarity : Belongs to the potassium channel family. G subfamily
Gene Function for KCNG4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172347 Applied Biosystems Silencer ® siRNAs for KCNG4 Sigma-Aldrich siRNA and siRNA Panels for KCNG4 Sigma-Aldrich shRNA Panels and shRNA for KCNG4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_133490                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_133490                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_133490  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_172347 UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 Function : Potassium channel subunit. Modulates channel activity by shifting the threshold and thehalf-maximal activation to more negative values
4 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005244 voltage-gated ion channel activity
IEA -- GO:0005249 voltage-gated potassium channel activity
IEA -- GO:0005515 protein binding
IEA -- GO:0030955 potassium ion binding
IEA --
About this table
Pathways & Interactions for KCNG4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for KCNG4 (ENSP00000312129 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006811 ion transport
IEA -- GO:0006813 potassium ion transport
IEA --
About this table
Drugs & Compounds for KCNG4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for KCNG4 available from Tocris Bioscience About this table
Transcripts for KCNG4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172347 Sigma-Aldrich siRNA and siRNA Panels for KCNG4 Sigma-Aldrich shRNA Panels and shRNA for KCNG4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_172347
REFSEQ mRNAs for KCNG4 gene (2 alternative transcripts): NM_133490.2 NM_172347.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_172347
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_133490                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_133490                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_133490  
Additional cDNA sequence: AF348984.1 AF450108.1 BC008969.2 BC109203.2
2 DOTS entries : DT.97821050 DT.86844971
9 AceView cDNA sequences :NM_172347 NM_133490 BC008969 AF450108 AF348984 AW409885 AW409623 BE270322 BE298461
highest scoring ESTs for KCNG4 :AW409885 BC008969 BE270322 BE298461 AF348984 AF450108 AW409623 NM_133490 NM_172347 BC109203
Unigene Cluster for KCNG4: Potassium voltage-gated channel, subfamily G, member 4 Hs.335877 [show with all ESTs ] Unigene Representative Sequence: BC008969 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000308251
Expression for KCNG4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KCNG4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KCNG4 1 / 2
1 probe-set matching KCNG4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGATTTAAGASOURCE GeneReport for Unigene cluster: Hs.335877 UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 Tissue specificity : Highly expressed in brain, and at lower levels in liver, small intestine andcolon
Orthologs for KCNG4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KCNG4 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
KCNG41
--
potassium voltage-gated channel, subfamily G, member more
85.76(n) 83.23(a)
489683 XM_546803.2 XP_546803.1
chimpanzee (Pan troglodytes)
KCNG41
--
potassium voltage-gated channel, subfamily G, member more
98.78(n) 98.65(a)
468051 XM_523443.2 XP_523443.2
cow (Bos taurus)
KCNG41
--
potassium voltage-gated channel, subfamily G, member more
86.68(n) 86.08(a)
534070 XM_613699.3 XP_613699.2
rat (Rattus norvegicus)
Kcng41
--
potassium voltage-gated channel, subfamily G, member more
82.34(n) 82.67(a)
307900 XM_226524.4 XP_226524.3
mouse (Mus musculus)
Kcng41 , 5
85
potassium voltage-gated channel, subfamily G, member more 1, 5
82.4(n) 1 82.87(a) 1
66733 1 NM_025734.2 1 NP_080010.2 1 AF450109 5 AK015001 5 (see all 9 )
About this table Species with no ortholog for KCNG4 ENSEMBL Gene Tree for KCNG4 Paralogs for KCNG4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KCNG4 gene KCNG3 2 KCNG2 2 KCNG1 2
SNPs/Variants for KCNG4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for KCNG4 (up to first 250kb)
Disorders & Mutations for KCNG4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607603
Medical News for KCNG4 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KCNG4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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7 PubMed articles for KCNG4 gene :
Search for KCNG4
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KCNG4
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KCNG4
(According to HUGE )
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--
Specialized Databases showing KCNG4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KCNG4 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for KCNG4:
Tocris compounds for KCNG4
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