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KCNG4 Gene

protein-coding   GIFtS: 47

GC16M082813
potassium voltage-gated channel, subfamily G, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KCNG3 3
KV6.3 2, 5
KV6.4 2, 5
Kv6.4 1
MGC129609 2
MGC4558 2
Descriptions
Voltage-gated potassium channel subunit Kv6.4 3
potassium voltage-gated channel, subfamily G, member 4 2
potassium voltage-gated channel, subfamily G, member 4,
isoform 1 2
voltage-gated potassium channel Kv6.3 2
External Ids
HGNC: 196971
Entrez Gene: 931072
UniProtKB: Q8TDN13
Ensembl: ENSG000001684187
Search outside databases for aliases for KCNG4 gene

Previous GC identifers: GC16M085222 GC16M083994 GC16M084035

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for KCNG4:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion
channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a
member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory
subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have
been found in normal and cancerous tissues. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the
half-maximal activation to more negative values

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNG4 gene  

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

KCNG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M082813:     (about GC identifiers)

Start:
82,813,324 bp from pter
End:
82,830,857 bp from pter
Size:
17,534 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010498.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 4  
Size: 519 amino acids; 58979 Da
Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Has to be associated with
KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in
the absence of KCNB1
Secondary accessions: Q96H24
Alternative splicing: 2 isoforms:  Q8TDN1-1   Q8TDN1-2   

REFSEQ proteins (2 alternative transcripts): 
NP_597997.1  NP_758857.1  


ENSEMBL proteins: 
ENSP00000312129 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0008076 voltage-gated potassium channel complex IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for KCNG4: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KCNG4

Assays for KCNG4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR005821 Ion_trans
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003971 K_chnl_volt-dep_Kv9
 IPR003968 K_chnl_volt-dep_Kv


   GeneDecks  KCNG4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8TDN1

ProtoNet protein and cluster: Q8TDN1

3 Blocks protein families:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003969 Kv6 potassium channel alpha subunit signature


UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of
positively charged amino acids at every third position
Similarity: Belongs to the potassium channel family. G subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG4)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172347

              Applied Biosystems Silencer® siRNAs for KCNG4

              Sigma-Aldrich siRNA and siRNA Panels for KCNG4  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_133490
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_133490
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133490 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_172347

UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the
half-maximal activation to more negative values

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity IEA--
GO:0005515 protein binding IEA--
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for KCNG4 (ENSP000003121293) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
GYG1ENSP000003407363STRING (score=.76)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCNG4 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG4)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG4)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172347

              Sigma-Aldrich siRNA and siRNA Panels for KCNG4  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_172347  

REFSEQ mRNAs for KCNG4 gene (2 alternative transcripts): 

NM_133490.2   NM_172347.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_172347  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_133490
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_133490
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133490 

Additional cDNA sequence: 

AF348984.1 AF450108.1 BC008969.2 BC109203.2 

2 DOTS entries:

DT.97821050  DT.86844971 

9 AceView cDNA sequences:

NM_172347 NM_133490 BC008969 AF450108 AF348984 AW409885 AW409623 BE270322 
BE298461 

highest scoring ESTs for KCNG4:

AW409885 BC008969 BE270322 BE298461 AF348984 AF450108 AW409623 NM_133490 NM_172347 BC109203 

Unigene Cluster for KCNG4:

Potassium voltage-gated channel, subfamily G, member 4
Hs.335877  [show with all ESTs]
Unigene Representative Sequence: BC008969


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000308251  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNG4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCNG4

1 / 2

1 probe-set matching KCNG4 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1552598_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGATTTAAGA

SOURCE GeneReport for Unigene cluster: Hs.335877

UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1
Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and
colon

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCNG4 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNG41   -- potassium voltage-gated channel, subfamily G, member more 85.76(n)
83.23(a)
489683  XM_546803.2  XP_546803.1 
chimpanzee
(Pan troglodytes)
KCNG41   -- potassium voltage-gated channel, subfamily G, member more 98.78(n)
98.65(a)
468051  XM_523443.2  XP_523443.2 
cow
(Bos taurus)
KCNG41   -- potassium voltage-gated channel, subfamily G, member more 86.68(n)
86.08(a)
534070  XM_613699.3  XP_613699.2 
rat
(Rattus norvegicus)
Kcng41   -- potassium voltage-gated channel, subfamily G, member more 82.34(n)
82.67(a)
307900  XM_226524.4  XP_226524.3 
mouse
(Mus musculus)
Kcng41, 5 85
potassium voltage-gated channel, subfamily G, member more1, 5 82.4(n)1
82.87(a)1
667331  NM_025734.21  NP_080010.21 
 AF4501095  AK0150015  (see all 9)
About this table        Species with no ortholog for KCNG4

ENSEMBL Gene Tree for KCNG4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCNG4 gene
KCNG32  KCNG22  KCNG12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/173 NCBI SNPs in KCNG4 are shown (see all 173 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 121)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs7347101,2
A,C,F,H,O82831935(-) AAGAAA/GGTGAA 1 -- ng3110Minor allele frequency- N:0.00NA EA EU WA 794
rs2448181,2
A,C,F,H,O82830933(+) AATCTT/CTCTTC 1 -- ng31 trp312Minor allele frequency- C:0.33EA NA EU WA 1044
rs71964821,2
A,C,F,H82813911(+) GCTCCC/TGCTCG 1 G/R mis1 ese35Minor allele frequency- T:0.17EU EA WA NA 498
rs7460801,2
A,C,F,H82831906(-) GAGCAC/ACTACA 1 -- ng318Minor allele frequency- A:0.09EU EA WA 826
rs177363701,2
C,F,H82814120(+) GAGAGC/TATTCG 1 C/Y mis116Minor allele frequency- T:0.09NA EU EA WA 1478
rs47829051,2
C,F,H82813923(+) CCTCTC/TGCCGT 1 E/K mis1 ese39Minor allele frequency- T:0.04EU EA WA NA 914
rs169630741,2
C,F,H82812953(+) CATAGG/ACTCAG 1 -- ng5115Minor allele frequency- A:0.16NA EU EA WA 1400
rs129202491,2
C,F,H82813270(+) AGTGTG/ATTTCA 1 -- ng518Minor allele frequency- A:0.07EU EA WA 840
rs47825991,2
C,F,H82832506(+) GGAACG/AAATCC 1 -- ng3111Minor allele frequency- A:0.11EU EA WA NA 976
rs116464431,2
C,F,H82827977(+) CAGCCG/AGTTCA 1 W/R mis112Minor allele frequency- A:0.23EU EA WA NA 1050
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HapMap Linkage Disequilibrium images for KCNG4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607603

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for KCNG4 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 93107 HGNC: 19697 AceView: KCNG4 Ensembl:ENSG00000168418 euGenes: HUgn93107
ECgene: KCNG4 H-InvDB: KCNG4
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCNG4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for KCNG4-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for KCNG4 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCNG4 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for KCNG4

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