KCNG4 Gene
protein-coding GIFtS: 52
GCID: GC16M084255
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potassium voltage-gated channel, subfamily G, member 4
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Aliases
for KCNG4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Potassium Voltage-Gated Channel, Subfamily G, Member 41 2 | | Kv6.41 | | Voltage-Gated Potassium Channel Subunit Kv6.42 3 | | Potassium Voltage-Gated Channel Subfamily G Member 42 | | KV6.32 5 | | Voltage-Gated Potassium Channel Kv6.32 | | KV6.42 5 | | KCNG33 |
Export aliases for KCNG4 gene to outside databasesPrevious GC identifers: GC16M085222 GC16M083994 GC16M084035 GC16M082813 GC16M070009 |
Summaries
for KCNG4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNG4:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from bothfunctional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heartrate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cellvolume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as amodulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been foundin normal and cancerous tissues. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximalactivation to more negative values
 summary
for KCNG4:Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Gene Wiki entry for KCNG4
|
Genomic Views
for KCNG4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNG4 gene promoter:
ER-alpha HEN1 S8 E2F E2F-1 HOXA5 SEF-1 (1) AP-4 ATF Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNG4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNG4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1KCNG4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M084255: view genomic region
(about GC identifiers)
Start:
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84,255,823 bp from pter |
End:
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84,273,356 bp from pter |
Size:
|
17,534 bases |
Orientation:
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minus strand |
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Proteins
for KCNG4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily G member 4 Size: 519 amino acids; 58979 Da
Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possiblyanother partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1
Secondary accessions: Q96H24Alternative splicing: 2 isoforms: Q8TDN1-1 Q8TDN1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KCNG4: NX_Q8TDN1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDN1
KCNG4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_758857.1
ENSEMBL proteins: ENSP00000312129 ENSP00000457897 Reactome Protein details: Q8TDN1
Human Recombinant Protein Products for KCNG4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0008076 | voltage-gated potassium channel complex |
IEA | -- |
KCNG4 for ontologies About GeneDecksing
KCNG4 Antibody Products:
Assay Products for KCNG4: |
Protein
Domains /
Families
for KCNG4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNG4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8TDN1ProtoNet protein and cluster: Q8TDN1 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003969 Kv6 potassium channel alpha subunit signature
UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third positionSimilarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily |
Function
for KCNG4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KCNG4_HUMAN, Q8TDN1Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximalactivation to more negative values Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005249 | voltage-gated potassium channel activity |
-- | -- | | GO:0005251 | delayed rectifier potassium channel activity |
IBA | -- |
KCNG4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for KCNG4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KCNG4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG4 |
|
Pathways & Interactions
for KCNG4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Potassium Channels | | | 2 | Dopamine-DARPP32 Feedback onto cAMP Pathway | | | 3 | Transmission across Chemical Synapses | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNG4
3 
Reactome Pathways for KCNG4
KCNG4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNG4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for KCNG4 (Q8TDN13 ENSP000003121294) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007268 | synaptic transmission |
TAS | -- | | GO:0051260 | protein homooligomerization |
IEA | -- |
KCNG4 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNG4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for KCNG4 available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about KCNG4
|
Transcripts
for KCNG4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KCNG4 gene (2 alternative transcripts): NM_172347.2 NM_133490.2 Unigene Clusters for KCNG4: Potassium voltage-gated channel, subfamily G, member 4 Hs.335877 [show with all ESTs], Hs.560407 Unigene Representative Sequences: BC008969, NM_1723472 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308251(uc010voc.2) ENST00000568181(uc002fhu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KCNG4 (NM_172347) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KCNG4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG4 |
Additional cDNA sequence: AF348984.1 AF450108.1 BC109203.2 2 DOTS entries: DT.97821050 DT.86844971 9 AceView cDNA sequences: NM_172347 AF450108 AF348984 BC008969 NM_133490 AW409885 AW409623 BE270322 BE298461
GeneLoc Exon Structure
|
Expression
for KCNG4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KCNG4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATTTAAGA
About this image
See KCNG4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNG4
SOURCE GeneReport for Unigene clusters: Hs.335877 Hs.560407
UniProtKB/Swiss-Prot: KCNG4_HUMAN, Q8TDN1Tissue specificity: Highly expressed in brain, and at lower levels in liver, small intestine and colon
SABiosciences Custom PCR Arrays for KCNG4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNG4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG4 |
Orthologs
for KCNG4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KCNG4 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for KCNG4 (if available)
TreeFam Gene Tree for KCNG4 (if available) |
Paralogs
for KCNG4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KCNG4 gene
- KCNG32 KCNF12 KCNB22 KCNV12 KCNG22 KCNS22 KCNS32 KCNB12
- KCNV22 KCNG12 KCNS12
18 SIMAP similar genes for KCNG4 using alignment to 3 protein entries: KCNG4_HUMAN (see all proteins):KCNG1 KCNG2 KCNB1 KCNB2 KCNG3 KCNS2
KCNF1 KCNS3 KCNV1 KCND1 KCNS1 KCNV2
KCND3 KCNC2 KCND2 KCNA1 KCNC1 KCNA2
KCNG4 for paralogs About GeneDecksing
|
Genomic Variants
for KCNG4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KCNG4 (84255823 - 84273356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNG4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNG4 |
|
Disorders
/ Diseases
for KCNG4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNG4 for disorders About GeneDecksing
OMIM gene information: 607603
OMIM disorders: --
3  diseases for KCNG4: About MalaCardsneuronitis fainting pharyngitis
Human Genome Epidemiology (HuGE) Navigator: KCNG4 (1 document)
Export disorders for KCNG4 gene to outside databases
|
Publications
for KCNG4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KCNG4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KCNG4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745)1, 2, 3 Ottschytsch N.... Snyders D.J. (2002)
- International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135)1 Mederos Y Schnitzler M.... Preisig-Muller R. (2009)
- Conserved negative charges in the N-terminal tetramer ization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. (PubMed id 19717558)1 Bocksteins E....Snyders D.J. (2009)
- Domain analysis of Kv6.3, an electrically silent channel. (PubMed id 16096342)1 Ottschytsch N....Snyders D.J. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for KCNG4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNG4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNG4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNG4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KCNG4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KCNG4 gene:
Search GeneIP for patents involving KCNG4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNG4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | KCNG4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KCNG4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG4 |
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