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KCNG3 Gene

protein-coding   GIFtS: 49

GC02M042523
potassium voltage-gated channel, subfamily G, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KV10.1 2
KV6.3 2, 5
Kv10.1 3
Kv6.3 1
OTTHUMP00000158764 2
Descriptions
Voltage-gated potassium channel subunit Kv6.3 3
potassium voltage-gated channel, subfamily G, member 3 2
voltage-gated potassium channel 6.3 2
voltage-gated potassium channel Kv10.1 2
voltage-gated potassium channel subunit Kv6.4 2
External Ids
HGNC: 183061
Entrez Gene: 1708502
UniProtKB: Q8TAE73
Ensembl: ENSG000001711267
Search outside databases for aliases for KCNG3 gene

Previous GC identifers: GC02M042659 GC02M042837 GC02M042643 GC02M042580

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KCNG3:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion
channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a
member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit
functioning as a modulatory molecule. Alternative splicing results in two transcript variants
encoding distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7
Function: Potassium channel subunit. Modulates channel activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNG3 gene  

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

KCNG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M042523:     (about GC identifiers)

Start:
42,522,661 bp from pter
End:
42,574,741 bp from pter
Size:
52,081 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 3  
Size: 436 amino acids; 49593 Da
Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane
protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the
plasma membrane. Remains intracellular in the absence of KCNB1
Alternative splicing: 2 isoforms:  Q8TAE7-1   Q8TAE7-2   

REFSEQ proteins (2 alternative transcripts): 
NP_579875.1  NP_758847.1  


ENSEMBL proteins: 
ENSP00000384611 ENSP00000385136 ENSP00000304127 ENSP00000378424 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (KCNG3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IDA12060745
GO:0005886 plasma membrane IDA12060745
GO:0008076 voltage-gated potassium channel complex IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for KCNG3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for KCNG3
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Monoclonal and Polyclonal Antibodies from Abnova (KCNG3)
Novus Biologicals Antibodies for KCNG3

Assays for KCNG3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR005821 Ion_trans
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003971 K_chnl_volt-dep_Kv9
 IPR003968 K_chnl_volt-dep_Kv


   GeneDecks  KCNG3 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8TAE7

ProtoNet protein and cluster: Q8TAE7

3 Blocks protein families:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003971 Kv9 potassium channel alpha subunit signature


UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of
positively charged amino acids at every third position
Similarity: Belongs to the potassium channel family. G subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172344

              Applied Biosystems Silencer® siRNAs for KCNG3

              Sigma-Aldrich siRNA and siRNA Panels for KCNG3  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for KCNG3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_133329
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_133329
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133329 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_133329

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7
Function: Potassium channel subunit. Modulates channel activity

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity IEA--
GO:0005515 protein binding IPI11852086
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  KCNG3 


2 Interacting proteins for KCNG3 (ENSP000003041273) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
GYG1ENSP000003407363STRING (score=.76)
KCNH1ENSP000002717513STRING (score=.741)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCNG3 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG3)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_172344

              Sigma-Aldrich siRNA and siRNA Panels for KCNG3  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_133329  NM_172344  

REFSEQ mRNAs for KCNG3 gene (2 alternative transcripts): 

NM_133329.4   NM_172344.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_133329  NM_172344  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_133329
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_133329
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133329 

Additional cDNA sequence: 

AB070604.1 AF348982.1 AF450110.1 AF454547.1 AF454548.1 BC071558.1 

2 DOTS entries:

DT.97824200  DT.100017441 

9 AceView cDNA sequences:

NM_133329 AB070604 BC071558 NM_172344 AF454547 AF348982 AF454548 BF966122 
AF450110 

highest scoring ESTs for KCNG3:

AB070604 AF348982 AF454547 AF454548 BC071558 BF966122 NM_133329 NM_172344 CN287828 CN294705 

Unigene Cluster for KCNG3:

Potassium voltage-gated channel, subfamily G, member 3
Hs.352633  [show with all ESTs]
Unigene Representative Sequence: NM_133329


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNG3

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:                              
SP2:              -               

About this scheme

ECgene alternative splicing isoforms for KCNG3

4 Ensembl transcripts including schematic representations:
ENST00000407047  ENST00000404422  ENST00000306078  ENST00000394973  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNG3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCNG3

1 / 2

2 probe-sets matching KCNG3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1552897_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1552898_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.352633

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7
Tissue specificity: Detected in many parts of the brain with the exception of the cerebellum, in
testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal
cord

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCNG3 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNG31   -- potassium voltage-gated channel, subfamily G, member more 95.95(n)
98.62(a)
483049  XM_540164.2  XP_540164.2 
chimpanzee
(Pan troglodytes)
KCNG31   -- potassium voltage-gated channel, subfamily G, member more 99.77(n)
100(a)
470361  XM_001138271.1  XP_001138271.1 
cow
(Bos taurus)
KCNG31   -- potassium voltage-gated channel, subfamily G, member more 95.11(n)
98.28(a)
525901  XM_001251844.1  XP_001251845.1 
rat
(Rattus norvegicus)
Kcng31   -- potassium voltage-gated channel, subfamily G, member more 92.69(n)
96.77(a)
171011  NM_133426.2  NP_596917.2 
mouse
(Mus musculus)
Kcng31, 5 175
potassium voltage-gated channel, subfamily G, member more1, 5 93.38(n)1
96.54(a)1
2250301  NM_153512.11  NP_705732.11 
 AF4545515  AF4545525  (see all 7)
About this table        Species with no ortholog for KCNG3

ENSEMBL Gene Tree for KCNG3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCNG3 gene
KCNG42  KCNG22  KCNG12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/292 NCBI SNPs in KCNG3 are shown (see all 292 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 78)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs116848521,2
A,C,F,H42523124(+) TGAGGT/CTTGAA 2 -- ut31 ese37Minor allele frequency- C:0.35NA EU EA WA 554
rs116915841,2
A,C,F,H42523902(+) TCATTA/TCAGTA 2 -- ut31 ese37Minor allele frequency- T:0.31NA EU EA WA 560
rs104958961,2
C,F,H42523362(+) TCTGTT/CGCTAA 2 -- ut3112Minor allele frequency- C:0.07NS EU EA WA NA 670
rs75763681,2
F,H42524494(+) TGCAGT/CGCTCA 2 -- ut31 ese34Minor allele frequency- C:0.03EU EA WA 418
rs14963281,2
A,C,F,H,O42531091(+) GACAAC/TTGCTG 2 -- int120Minor allele frequency- N:0.00EU EA WA NA 1834
rs7136121,2
A,C,F,H,O42570125(-) CTAAGC/TTGGAT 2 -- int117Minor allele frequency- N:0.00NA EA NS EU WA 1083
rs14963301,2
A,C,F,H,O42545737(+) TTAGAG/AATAAT 2 -- int17Minor allele frequency- A:0.35NA EU EA WA 558
rs20882811,2
A,C,F,H,O42526235(+) TTTGTG/ATTCCA 2 -- int111Minor allele frequency- A:0.15EU EA WA NA 980
rs13906131,2
A,C,F,H,O42570167(-) TTAGCG/ATGATG 2 -- int113Minor allele frequency- A:0.26NS EU EA WA NA 736
rs19797551,2
A,C,F,H,O42561909(-) ATATTC/GTTATA 2 -- int119Minor allele frequency- N:0.00NA EA EU WA 1724
About this table

HapMap Linkage Disequilibrium images for KCNG3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606767

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for KCNG3 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 170850 HGNC: 18306 AceView: KCNG3 Ensembl:ENSG00000171126 euGenes: HUgn170850
ECgene: KCNG3 H-InvDB: KCNG3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCNG3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
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 Predesigned and custom siRNAs for KCNG3 Antibodies for KCNG3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCNG3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for KCNG3

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