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Aliases & Descriptions for KCNG3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KV10.1 2 KV6.3 2 , 5 Kv10.1 3 Kv6.3 1 OTTHUMP00000158764 2
Descriptions Voltage-gated potassium channel subunit Kv6.3 3 potassium voltage-gated channel, subfamily G, member 3 2 voltage-gated potassium channel 6.3 2 voltage-gated potassium channel Kv10.1 2 voltage-gated potassium channel subunit Kv6.4 2
Search outside databases for aliases for KCNG3 genePrevious GC identifers: GC02M042659 GC02M042837 GC02M042643 GC02M042580
Summaries for KCNG3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for KCNG3 : Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ionchannels from both functional and structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes amember of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunitfunctioning as a modulatory molecule. Alternative splicing results in two transcript variantsencoding distinct isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 Function : Potassium channel subunit. Modulates channel activity
Genomic Location for KCNG3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the KCNG3 gene Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21 KCNG3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M042523:
(about GC identifiers )
Start:
42,522,661 bp from pter
End:
42,574,741 bp from pter
Size:
52,081 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_022184.14 Proteins for KCNG3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 (See
protein sequence )Recommended Name: Potassium voltage-gated channel subfamily G member 3 Size : 436 amino acids; 49593 Da
Subunit : Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers
Subcellular location : Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membraneprotein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in theplasma membrane. Remains intracellular in the absence of KCNB1 Alternative splicing : 2 isoforms : Q8TAE7-1 Q8TAE7-2
REFSEQ proteins (2 alternative transcripts):
NP_579875.1 NP_758847.1 ENSEMBL proteins: ENSP00000384611 ENSP00000385136 ENSP00000304127 ENSP00000378424 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for KCNG3: Assays for KCNG3:
Protein
Domains/ Families for KCNG3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8TAE7 ProtoNet protein and cluster: Q8TAE7
3 Blocks protein families : IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003971 Kv9 potassium channel alpha subunit signature UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 Domain : The segment S4 is probably the voltage-sensor and is characterized by a series ofpositively charged amino acids at every third position Similarity : Belongs to the potassium channel family. G subfamily
Gene Function for KCNG3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172344 Applied Biosystems Silencer ® siRNAs for KCNG3 Sigma-Aldrich siRNA and siRNA Panels for KCNG3 Sigma-Aldrich shRNA Panels and shRNA for KCNG3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_133329                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_133329                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_133329  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_133329 UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 Function : Potassium channel subunit. Modulates channel activity
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for KCNG3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for KCNG3 2 Interacting proteins for KCNG3 (ENSP00000304127 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006811 ion transport
IEA -- GO:0006813 potassium ion transport
IEA --
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Drugs & Compounds for KCNG3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for KCNG3 available from Tocris Bioscience About this table
Transcripts for KCNG3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_172344 Sigma-Aldrich siRNA and siRNA Panels for KCNG3 Sigma-Aldrich shRNA Panels and shRNA for KCNG3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_133329 NM_172344
REFSEQ mRNAs for KCNG3 gene (2 alternative transcripts): NM_133329.4 NM_172344.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_133329 NM_172344
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_133329                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_133329                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_133329  
Additional cDNA sequence: AB070604.1 AF348982.1 AF450110.1 AF454547.1 AF454548.1 BC071558.1
2 DOTS entries : DT.97824200 DT.100017441
9 AceView cDNA sequences :NM_133329 AB070604 BC071558 NM_172344 AF454547 AF348982 AF454548 BF966122 AF450110
highest scoring ESTs for KCNG3 :AB070604 AF348982 AF454547 AF454548 BC071558 BF966122 NM_133329 NM_172344 CN287828 CN294705
Unigene Cluster for KCNG3: Potassium voltage-gated channel, subfamily G, member 3 Hs.352633 [show with all ESTs ] Unigene Representative Sequence: NM_133329 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNG3 ExUns: 1a · 1b · 1c ^ 2a · 2b SP1 :           SP2 :     -      
About this scheme ECgene alternative splicing isoforms for KCNG3 4 Ensembl transcripts including schematic representations : ENST00000407047
ENST00000404422
ENST00000306078
ENST00000394973
Expression for KCNG3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KCNG3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KCNG3 1 / 2
2 probe-sets matching KCNG3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.352633 UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 Tissue specificity : Detected in many parts of the brain with the exception of the cerebellum, intestis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinalcord
Orthologs for KCNG3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KCNG3 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
KCNG31
--
potassium voltage-gated channel, subfamily G, member more
95.95(n) 98.62(a)
483049 XM_540164.2 XP_540164.2
chimpanzee (Pan troglodytes)
KCNG31
--
potassium voltage-gated channel, subfamily G, member more
99.77(n) 100(a)
470361 XM_001138271.1 XP_001138271.1
cow (Bos taurus)
KCNG31
--
potassium voltage-gated channel, subfamily G, member more
95.11(n) 98.28(a)
525901 XM_001251844.1 XP_001251845.1
rat (Rattus norvegicus)
Kcng31
--
potassium voltage-gated channel, subfamily G, member more
92.69(n) 96.77(a)
171011 NM_133426.2 NP_596917.2
mouse (Mus musculus)
Kcng31 , 5
175
potassium voltage-gated channel, subfamily G, member more 1, 5
93.38(n) 1 96.54(a) 1
225030 1 NM_153512.1 1 NP_705732.1 1 AF454551 5 AF454552 5 (see all 7 )
About this table Species with no ortholog for KCNG3 ENSEMBL Gene Tree for KCNG3 Paralogs for KCNG3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KCNG3 gene KCNG4 2 KCNG2 2 KCNG1 2
SNPs/Variants for KCNG3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for KCNG3 (up to first 250kb)
Disorders & Mutations for KCNG3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606767
Medical News for KCNG3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KCNG3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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7 PubMed articles for KCNG3 gene : Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. (PubMed id 11852086) 2, 3, 4 Sano Y.... Furuichi K. (2002) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104) 2, 3 Gutman G.A....Wang X. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745) 3, 4 Ottschytsch N.... Snyders D.J. (2002) Modification of Kv2.1 K+ currents by the silent Kv10 subunits. (PubMed id 15046870) 1, 3 Vega-Saenz de Miera E.C. (2004) Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135) 3 Mederos Y Schnitzler M.... Preisig-Muller R. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing KCNG3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KCNG3
(According to HUGE )
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--
Specialized Databases showing KCNG3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KCNG3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for KCNG3:
Tocris compounds for KCNG3
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