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Aliases for KCNG3 Gene

Aliases for KCNG3 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 3 2 3
  • Potassium Voltage-Gated Channel, Subfamily G, Member 3 2 3
  • Voltage-Gated Potassium Channel Subunit Kv10.1 3 4
  • Voltage-Gated Potassium Channel Subunit Kv6.3 3 4
  • KV6.3 3 6
  • Potassium Voltage-Gated Channel Subfamily G Member 3 3
  • Voltage-Gated Potassium Channel Subunit Kv6.4 3
  • Voltage-Gated Potassium Channel Kv10.1 3
  • Voltage-Gated Potassium Channel 6.3 3
  • Kv10.1 3

External Ids for KCNG3 Gene

Summaries for KCNG3 Gene

Entrez Gene Summary for KCNG3 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG3 Gene

KCNG3 (Potassium Channel, Voltage Gated Modifier Subfamily G, Member 3) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNG3 Gene

  • Potassium channel subunit. Modulates channel activity

Tocris Summary for KCNG3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG3 Gene

Genomics for KCNG3 Gene

Genomic Location for KCNG3 Gene

Start:
42,442,017 bp from pter
End:
42,494,097 bp from pter
Size:
52,081 bases
Orientation:
Minus strand

Genomic View for KCNG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG3 Gene

Regulatory Elements for KCNG3 Gene

Proteins for KCNG3 Gene

  • Protein details for KCNG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE7-KCNG3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 3
    Protein Accession:
    Q8TAE7
    Secondary Accessions:
    • Q53SC1

    Protein attributes for KCNG3 Gene

    Size:
    436 amino acids
    Molecular mass:
    49593 Da
    Quaternary structure:
    • Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers

    Alternative splice isoforms for KCNG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG3 Gene

Proteomics data for KCNG3 Gene at MOPED

Post-translational modifications for KCNG3 Gene

No Post-translational modifications

Other Protein References for KCNG3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG3 Gene

Domains for KCNG3 Gene

Gene Families for KCNG3 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNG3_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q8TAE7
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily.:
    • Q8TAE7
genes like me logo Genes that share domains with KCNG3: view

Function for KCNG3 Gene

Molecular function for KCNG3 Gene

UniProtKB/Swiss-Prot Function: Potassium channel subunit. Modulates channel activity

Gene Ontology (GO) - Molecular Function for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding IPI 11852086
genes like me logo Genes that share ontologies with KCNG3: view

Phenotypes for KCNG3 Gene

GenomeRNAi human phenotypes for KCNG3:
genes like me logo Genes that share phenotypes with KCNG3: view

miRNA for KCNG3 Gene

miRTarBase miRNAs that target KCNG3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNG3 Gene

Localization for KCNG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG3 Gene

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNG3 Gene COMPARTMENTS Subcellular localization image for KCNG3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12060745
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNG3: view

Pathways for KCNG3 Gene

genes like me logo Genes that share pathways with KCNG3: view

Pathways by source for KCNG3 Gene

1 Qiagen pathway for KCNG3 Gene

Gene Ontology (GO) - Biological Process for KCNG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCNG3: view

Compounds for KCNG3 Gene

(5) Tocris Compounds for KCNG3 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
genes like me logo Genes that share compounds with KCNG3: view

Transcripts for KCNG3 Gene

mRNA/cDNA for KCNG3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNG3 Gene

Potassium voltage-gated channel, subfamily G, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for KCNG3 Gene

GeneLoc Exon Structure for
KCNG3
ECgene alternative splicing isoforms for
KCNG3

Expression for KCNG3 Gene

mRNA expression in normal human tissues for KCNG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.7), Brain - Putamen (basal ganglia) (4.7), Brain - Caudate (basal ganglia) (4.5), and Brain - Anterior cingulate cortex (BA24) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNG3 Gene

SOURCE GeneReport for Unigene cluster for KCNG3 Gene Hs.352633

mRNA Expression by UniProt/SwissProt for KCNG3 Gene

Q8TAE7-KCNG3_HUMAN
Tissue specificity: Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord
genes like me logo Genes that share expressions with KCNG3: view

Orthologs for KCNG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNG3 36
  • 99.77 (n)
  • 100 (a)
KCNG3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNG3 37
  • 98 (a)
OneToOne
LOC525901 36
  • 95.47 (n)
  • 98.49 (a)
dog
(Canis familiaris)
Mammalia KCNG3 36
  • 95.95 (n)
  • 98.62 (a)
KCNG3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcng3 36
  • 93.38 (n)
  • 96.54 (a)
Kcng3 16
Kcng3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNG3 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNG3 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcng3 36
  • 92.69 (n)
  • 96.77 (a)
chicken
(Gallus gallus)
Aves KCNG3 36
  • 82.83 (n)
  • 86.77 (a)
KCNG3 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNG3 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcng3 36
  • 75.72 (n)
  • 82.9 (a)
zebrafish
(Danio rerio)
Actinopterygii kcng3 36
  • 68.82 (n)
  • 80.38 (a)
kcng3 37
  • 78 (a)
OneToOne
Species with no ortholog for KCNG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG3 Gene

ENSEMBL:
Gene Tree for KCNG3 (if available)
TreeFam:
Gene Tree for KCNG3 (if available)

Paralogs for KCNG3 Gene

Paralogs for KCNG3 Gene

Selected SIMAP similar genes for KCNG3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNG3: view

Variants for KCNG3 Gene

Sequence variations from dbSNP and Humsavar for KCNG3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs713611 -- 42,489,844(-) AGTCA(A/G)AATTA intron-variant
rs713612 -- 42,489,481(-) CTAAG(C/T)TGGAT intron-variant
rs1390610 -- 42,489,875(-) AGAAA(G/T)GACAA intron-variant
rs1390611 -- 42,489,740(-) GTCCA(G/T)CCTGG intron-variant
rs1390612 -- 42,489,574(-) CTTAA(A/G)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNG3 Gene

Variant ID Type Subtype PubMed ID
nsv873970 CNV Gain 21882294
nsv524679 CNV Loss 19592680
esv2671664 CNV Deletion 23128226
esv23097 CNV Loss 19812545

Relevant External Links for KCNG3 Gene

HapMap Linkage Disequilibrium report
KCNG3

Disorders for KCNG3 Gene

Relevant External Links for KCNG3

Genetic Association Database (GAD)
KCNG3
Human Genome Epidemiology (HuGE) Navigator
KCNG3
genes like me logo Genes that share disorders with KCNG3: view

No data available for UniProtKB/Swiss-Prot for KCNG3 Gene

Publications for KCNG3 Gene

  1. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. (PMID: 11852086) Sano Y. … Furuichi K. (FEBS Lett. 2002) 2 3 4
  2. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PMID: 12060745) Ottschytsch N. … Snyders D.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  3. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. (PMID: 15046870) Vega-Saenz de Miera E.C. (Brain Res. Mol. Brain Res. 2004) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3

Products for KCNG3 Gene

Sources for KCNG3 Gene

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