Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KCNG3 Gene

protein-coding GIFtS: 55
GCID: GC02M042669

potassium voltage-gated channel, subfamily G, member 3

Explore 3 diseases affiliated with
KCNG3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Subfamily G, Member 3¹ ²		KV10.1²
Voltage-Gated Potassium Channel Subunit Kv10.1² ³		Potassium Voltage-Gated Channel Subfamily G Member 3²
Voltage-Gated Potassium Channel Subunit Kv6.3² ³		Voltage-Gated Potassium Channel 6.3²
KV6.3² ⁵		Voltage-Gated Potassium Channel Kv10.1²
Kv6.3¹		Voltage-Gated Potassium Channel Subunit Kv6.4²

External Ids:	HGNC: 18306¹	Entrez Gene: 170850²	Ensembl: ENSG00000171126⁷	OMIM: 606767⁵	UniProtKB: Q8TAE7³

Export aliases for KCNG3 gene to outside databases

Previous GC identifers: GC02M042659 GC02M042837 GC02M042643 GC02M042580 GC02M042523 GC02M042403

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNG3:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both

functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart

rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell

volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma

subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding

distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7

Function: Potassium channel subunit. Modulates channel activity

summary for KCNG3:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNG3 gene promoter:
LHX3b/Lhx3b Sp1 HTF AP-4 S8 POU2F1 FOXO4 POU2F1a LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KCNG3 promoter sequence

Search SABiosciences Chromatin IP Primers for KCNG3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNG3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21

KCNG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNG3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M042669: view genomic region (about GC identifiers)

Start:	42,669,157 bp from pter	End:	42,721,237 bp from pter
Size:	52,081 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily G member 3

Size: 436 amino acids; 49593 Da

Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers

Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Has to be

associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the

absence of KCNB1

Secondary accessions: Q53SC1

Alternative splicing: 2 isoforms: Q8TAE7-1 Q8TAE7-2

Explore the universe of human proteins at neXtProt for KCNG3: NX_Q8TAE7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TAE7

KCNG3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_579875.1 NP_758847.1

ENSEMBL proteins:

ENSP00000304127 ENSP00000378424

Reactome Protein details: Q8TAE7
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): KCNG3 OriGene Custom Protein Services for KCNG3
	GenScript Custom Purified and Recombinant Proteins Services for KCNG3
	Novus Biologicals KCNG3 Protein Novus Biologicals KCNG3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KCNG3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	12060745
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IEA	--

KCNG3 for ontologies About GeneDecksing

KCNG3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KCNG3
	GenScript Custom Superior Antibodies Services for KCNG3
	Novus Biologicals KCNG3 Antibodies
	Search for Antibodies for KCNG3 at Abcam
	Uscn Antibodies for KCNG3
	ThermoFisher Antibodies for KCNG3

Assay Products for KCNG3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KCNG3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KCNG3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNG3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005821 Ion_trans_dom

IPR000210 BTB/POZ-like

IPR011333 BTB/POZ_fold

IPR003971 K_chnl_volt-dep_Kv9

IPR003968 K_chnl_volt-dep_Kv

Graphical View of Domain Structure for InterPro Entry Q8TAE7

ProtoNet protein and cluster: Q8TAE7

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB003091 Potassium channel signature

IPB003971 Kv9 potassium channel alpha subunit signature

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Similarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7

Function: Potassium channel subunit. Modulates channel activity

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KCNG3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNG3
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNG3 (see all 34):
		hsa-miR-548j hsa-miR-136 hsa-miR-4307 hsa-miR-607 hsa-miR-188-5p hsa-miR-548k hsa-miR-548l hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: KCNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG3 (see all 7) OriGene shRNA RFP: KCNG3 OriGene siRNA: KCNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KCNG3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KCNG3 (NM_133329)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KCNG3
		Search LifeMap BioReagents cell lines for KCNG3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005249	voltage-gated potassium channel activity	--	--
GO:0005251	delayed rectifier potassium channel activity	IBA	--
GO:0005515	protein binding	IPI	11852086

KCNG3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KCNG3:

Increased cell death HMECs cel

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Potassium Channels

Potassium Channels

1.00

Voltage gated Potassium channels

0.43

Dopamine-DARPP32 Feedback onto cAMP Pathway

Dopamine-DARPP32 Feedback onto cAMP Pathway

1.00

Transmission across Chemical Synapses

Neuronal System

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNG3

Dopamine-DARPP32 Feedback onto cAMP Pathway

3 Reactome Pathways for KCNG3

	Potassium Channels
	Neuronal System
	Voltage gated Potassium channels

KCNG3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNG3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for KCNG3 (Q8TAE7³ ENSP00000304127⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNB1	Q14721³, ENSP00000360806⁴	I2D: score=2 STRING: ENSP00000360806
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
KCNC1	P48547³, ENSP00000265969⁴	I2D: score=1 STRING: ENSP00000265969
KCNF1	Q9H3M0³, ENSP00000295082⁴	I2D: score=2 STRING: ENSP00000295082
KCNA10	ENSP00000358786⁴	STRING: ENSP00000358786

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006813	potassium ion transport	--	--
GO:0007268	synaptic transmission	TAS	--
GO:0051260	protein homooligomerization	IEA	--

KCNG3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNG3 available from Tocris Bioscience About this table

Compound	Action	CAS #
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

Search CenterWatch for drugs/clinical trials and news about KCNG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNG3 gene (2 alternative transcripts):

NM_133329.5 NM_172344.2

Unigene Cluster for KCNG3:

Potassium voltage-gated channel, subfamily G, member 3

Hs.352633 [show with all ESTs]

Unigene Representative Sequence: NM_133329

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306078(uc002rsm.3 uc002rsn.3) ENST00000394973

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KCNG3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNG3
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNG3 (see all 34):
		hsa-miR-548j hsa-miR-136 hsa-miR-4307 hsa-miR-607 hsa-miR-188-5p hsa-miR-548k hsa-miR-548l hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: KCNG3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG3 (see all 7) OriGene shRNA RFP: KCNG3 OriGene siRNA: KCNG3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): KCNG3 (NM_133329)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNG3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG3

Additional cDNA sequence:

AB070604.1 AF348982.1 AF454547.1 AF454548.1 BC071558.1

2 DOTS entries:

DT.97824200 DT.100017441

9 AceView cDNA sequences:

AB070604 NM_172344 BC071558 NM_133329 AF454548 AF454547 AF348982 BF966122

AF450110

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KCNG3 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b
SP1:
SP2:					-

ECgene alternative splicing isoforms for KCNG3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KCNG3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KCNG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNG3

SOURCE GeneReport for Unigene cluster: Hs.352633

UniProtKB/Swiss-Prot: KCNG3_HUMAN, Q8TAE7

Tissue specificity: Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas,

lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord

SABiosciences Custom PCR Arrays for KCNG3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KCNG3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KCNG3 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KCNG3¹	potassium voltage-gated channel, subfamily G, member more	82.83(n) 86.77(a)		421393 XM_419451.3 XP_419451.3
lizard (Anolis carolinensis)	Reptilia	KCNG3⁶	--	75(a)	1 ↔ 1	GL343231.1(82192-106543)
zebrafish (Danio rerio)	Actinopterygii	kcng3¹	potassium voltage-gated channel, subfamily G, member more	68.98(n) 80.14(a)		565643 XM_688909.2 XP_694001.2
honey bee (Apis mellifera)	Insecta	--	--	24(a)	possible ortholog	Group13.15(957-3745)
worm (Caenorhabditis elegans)	Secernentea	kvs-3⁶ C32C4.1⁶ (see all 6)	Protein C32C4.1, isoform a (see all 6)	26(a) 23(a) (see all 6)	many ↔ many many ↔ many (see all 6)	V(9318279-9320971) V(10636001-10645105)

ENSEMBL Gene Tree for KCNG3 (if available)
TreeFam Gene Tree for KCNG3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KCNG3 gene

KCNF1² KCNB2² KCNV1² KCNG2² KCNS2² KCNS3² KCNB1² KCNV2²

KCNG4² KCNG1² KCNS1²

18/19 SIMAP similar genes for KCNG3 using alignment to 1 protein entry: KCNG3_HUMAN(see all similar genes):

KCNG1 KCNG2 KCNG4 KCNB1 KCNB2 KCNS2

KCNS1 KCNS3 KCNV1 KCNF1 KCNV2 KCND3

KCNA1 KCNA3 KCNC1 KCNA7 KCNC4 KCNA10

KCNG3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201293756^1,2	C	--	42454321(+)	`CGCGCC/TTGGGC`	1	--	us2k¹		0	--	--	--	--
rs7578869^1,2	C,	--	42455197(+)	`TGCCTG/TCCCGT`	1	--	us2k¹		0	--	--	--	--
rs34702230^1,2	C	--	42455330(+)	`CGGCGG/TTACCT`	1	--	us2k¹		1		NA	2
rs10153860^1,2	C,	--	42456993(+)	`AAAAGC/TTCAAA`	1	--	ut3¹		2		NA	122
rs3821230^1,2	C,	--	42457123(-)	`TTGTTT/CAATAT`	1	--	ds500¹		1		EA	120
rs73930422^1,2	C,	--	42457126(+)	`TTAAAC/GAAGAA`	1	--	ds500¹		2		WA	120
rs78240960^1,2	C,	--	42457386(+)	`TTCAGG/AAAGAT`	1	--	ds500¹		3		NA EA	242
rs186739206^1,2		--	42668675(+)	`ATCACA/GTCTCA`	2	--	ds500¹		0	--	--	--	--
rs191878822^1,2		--	42668779(+)	`CAACAA/GGAGAT`	2	--	ds500¹		0	--	--	--	--
rs143062894^1,2		--	42668843(+)	`TACAT-/TATATAT`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KCNG3 (42669157 - 42721237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNG3
1 Indel: 73401

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNG3

DNA2.0 Custom Variant and Variant Library Synthesis for KCNG3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNG3 for disorders           About GeneDecksing

OMIM gene information: 606767    OMIM disorders: --

3 diseases for KCNG3:    About MalaCards

neuronitis fainting pharyngitis

Human Genome Epidemiology (HuGE) Navigator: KCNG3 (1 document)

Export disorders for KCNG3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KCNG3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KCNG3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. (PubMed id 11852086)^{1, 2, 3} Sano Y.... Furuichi K. (2002)
International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745)^{1, 2} Ottschytsch N.... Snyders D.J. (2002)
Modification of Kv2.1 K+ currents by the silent Kv10 subunits. (PubMed id 15046870)^{1, 9} Vega-Saenz de Miera E.C. (2004)
Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy. (PubMed id 22204340)¹ Pardo L.A....Stuhmer W. (2012)
Mutation of histidine 105 in the t1 domain of the potassium channel kv2.1 disrupts heteromerization with kv6.3 and kv6.4. (PubMed id 19074135)¹ Mederos Y Schnitzler M.... Preisig-Muller R. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 170850	HGNC: 18306	AceView: KCNG3	Ensembl:ENSG00000171126	euGenes: HUgn170850
ECgene: KCNG3	H-InvDB: KCNG3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KCNG3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KCNG3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KCNG3 gene:
Search GeneIP for patents involving KCNG3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KCNG3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG3
	OriGene Protein Over-expression Lysate for KCNG3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KCNG3		OriGene 3'-UTR Clone for KCNG3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KCNG3		OriGene Custom Protein Services for KCNG3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNG3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNG3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNG3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG3

	GenScript Custom Purified and Recombinant Proteins Services for KCNG3		GenScript cDNA clones with any tag delivered in your preferred vector for KCNG3
	GenScript Custom Assay Services for KCNG3		GenScript Custom Superior Antibodies Services for KCNG3
	GenScript Custom overexpressing Cell Line Services for KCNG3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNG3 promoter
	Search Chromatin IP Primers for KCNG3
	RT² qPCR Primer Assay in human, mouse, rat KCNG3
	GNC Network for KCNG3
	SABiosciences PCR Arrays including human, mouse, rat KCNG3

Tocris compounds for KCNG3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KCNG3 antibodies
	KCNG3 proteins
	KCNG3 lysates

	Search for Antibodies for KCNG3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KCNG3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

KCNG3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for KCNG3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG3

	SwitchGear 3'UTR luciferase reporter plasmids for KCNG3
	SwitchGear Promoter luciferase reporter plasmids for KCNG3

ThermoFisher Antibodies for KCNG3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNG3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KCNG3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KCNG3 Gene

potassium voltage-gated channel, subfamily G, member 3

Aliases
for KCNG3 gene

Summaries
for KCNG3 gene

Genomic Views
for KCNG3 gene

Proteins
for KCNG3 gene

Protein Domains /
Families
for KCNG3 gene

Function
for KCNG3 gene

Pathways & Interactions
for KCNG3 gene

Drugs & Compounds
for KCNG3 gene

Transcripts
for KCNG3 gene

Expression
for KCNG3 gene

Orthologs
for KCNG3 gene

Paralogs
for KCNG3 gene

Genomic Variants
for KCNG3 gene

Disorders / Diseases
for KCNG3 gene

Publications
for KCNG3 gene

External Searches for KCNG3 gene

Genome Databases showing KCNG3 gene

Other Databases showing KCNG3 gene

Specialized Databases showing KCNG3 gene

Intellectual Property
for KCNG3 gene

Products
for KCNG3 gene

View Random Gene

Advanced Search

Export list of displayed genes

KCNG3 Gene

potassium voltage-gated channel, subfamily G, member 3

Aliasesfor KCNG3 gene

Summariesfor KCNG3 gene

Genomic Viewsfor KCNG3 gene

Proteinsfor KCNG3 gene

Protein Domains /Familiesfor KCNG3 gene

Functionfor KCNG3 gene

Pathways & Interactionsfor KCNG3 gene

Drugs & Compoundsfor KCNG3 gene

Transcriptsfor KCNG3 gene

Expression for KCNG3 gene

Orthologsfor KCNG3 gene

Paralogsfor KCNG3 gene

Genomic Variantsfor KCNG3 gene

Disorders / Diseasesfor KCNG3 gene

Publicationsfor KCNG3 gene

External Searches for KCNG3 gene

Genome Databases showing KCNG3 gene

Other Databases showing KCNG3 gene

Specialized Databases showing KCNG3 gene

Intellectual Propertyfor KCNG3 gene

Productsfor KCNG3 gene

View Random Gene

Aliases
for KCNG3 gene

Summaries
for KCNG3 gene

Genomic Views
for KCNG3 gene

Proteins
for KCNG3 gene

Protein Domains /
Families
for KCNG3 gene

Function
for KCNG3 gene

Pathways & Interactions
for KCNG3 gene

Drugs & Compounds
for KCNG3 gene

Transcripts
for KCNG3 gene

Expression
for KCNG3 gene

Orthologs
for KCNG3 gene

Paralogs
for KCNG3 gene

Genomic Variants
for KCNG3 gene

Disorders / Diseases
for KCNG3 gene

Publications
for KCNG3 gene

Intellectual Property
for KCNG3 gene

Products
for KCNG3 gene