Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNG2 Gene

protein-coding   GIFtS: 52
GCID: GC18P077677

potassium voltage-gated channel, subfamily G, member 2
 Explore 4 diseases affiliated with
KCNG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KCNG2    

Aliases
for KCNG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Potassium Voltage-Gated Channel, Subfamily G, Member 21 2     Kv6.21
KCNF21 2 3     KV6.22
Cardiac Potassium Channel Subunit2 3     Potassium Voltage-Gated Channel Subfamily G Member 22
Voltage-Gated Potassium Channel Subunit Kv6.22 3     

External Ids:    HGNC: 62491   Entrez Gene: 262512   Ensembl: ENSG000001783427   OMIM: 6056965   UniProtKB: Q9UJ963   

Export aliases for KCNG2 gene to outside databases

Previous GC identifers: GC18P077138 GC18P077358 GC18P075722 GC18P075724 GC18P074246


Summaries
for KCNG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KCNG2:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma
subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may
contribute to cardiac action potential repolarization. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96
Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal
activation to more negative values

summary for KCNG2:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG2


Genomic Views
for KCNG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNG2 gene promoter:
         AhR   AP-2gamma   GATA-1   Arnt   GATA-2   Max   POU2F1a   ATF   c-Myc   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KCNG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23   Ensembl cytogenetic band:  18q23   HGNC cytogenetic band: 18q23

KCNG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNG2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P077677:  view genomic region     (about GC identifiers)

Start:
 77,623,668 bp from pter      End:
 77,660,184 bp from pter
Size:
 36,517 bases      Orientation:
 plus strand

Proteins
for KCNG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 2  
Size: 466 amino acids; 51240 Da
Subunit: Heterodimer with KCNB1. Does not form homomultimers
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone

Explore the universe of human proteins at neXtProt for KCNG2: NX_Q9UJ96

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJ96

    • KCNG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036415.1  
    ENSEMBL proteins: 
     ENSP00000315654  
    Reactome Protein details: Q9UJ96
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KCNG2
    OriGene Custom Protein Services for KCNG2 
    GenScript Custom Purified and Recombinant Proteins Services for KCNG2
    Novus Biologicals KCNG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KCNG2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--


    KCNG2 for ontologies           About GeneDecksing



    KCNG2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KCNG2 
    GenScript Custom Superior Antibodies Services for KCNG2
    Novus Biologicals KCNG2 Antibodies
    Search for Antibodies for KCNG2 at Abcam  
    Uscn Antibodies for KCNG2
    Search ThermoFisher Antibodies for KCNG2

    Assay Products for KCNG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNG2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KCNG2

    Protein Domains /
    Families
    for KCNG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KCNG2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR003968 K_chnl_volt-dep_Kv
     IPR003131 T1-type_BTB

    Graphical View of Domain Structure for InterPro Entry Q9UJ96

    ProtoNet protein and cluster: Q9UJ96

    3 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003969 Kv6 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily


    Function
    for KCNG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96
    Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal
    activation to more negative values

         Genatlas biochemistry entry for KCNG2:
    potassium voltage-gated channel,subfamily G,member 2,rat Kv6.2 homolog,preferentially expressed in myocard

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNG2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KCNG2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG2 (see all 4)
    OriGene shRNA RFP: KCNG2
    OriGene siRNA: KCNG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KCNG2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KCNG2 (NM_012283)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNG2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNG2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KCNG2
    Search LifeMap BioReagents cell lines for KCNG2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KCNG2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005251delayed rectifier potassium channel activity TAS10551266


    KCNG2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KCNG2:
     Increased circadian period len 


    Pathways & Interactions
    for KCNG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Insulin Secretion
    		Regulation of Insulin Secretion1.00
    		Regulation of Insulin Secretion by Glucagon-like Peptide-10.55
    		Integration of energy metabolism0.74
    2Potassium Channels
    		Potassium Channels1.00
    		Voltage gated Potassium channels0.43
    3Metabolism
    		Metabolism1.00
    4Dopamine-DARPP32 Feedback onto cAMP Pathway
    		Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
    5Closing of Potassium voltage-gated channels by PKA
    		Closing of Potassium voltage-gated channels by PKA1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNG2
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    5/8        Reactome Pathways for KCNG2 (see all 8)
        Potassium Channels
    Regulation of Insulin Secretion by Glucagon-like Peptide-1
    Closing of Potassium voltage-gated channels by PKA
    Metabolism
    Regulation of Insulin Secretion



    KCNG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for KCNG2 (Q9UJ963 ENSP000003156544) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNB1Q147213, ENSP000003608064I2D: score=2 STRING: ENSP00000360806
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006813potassium ion transport TAS10551266
    GO:0007268synaptic transmission TAS--
    GO:0008016regulation of heart contraction TAS10551266
    GO:0044281small molecule metabolic process TAS--


    KCNG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KCNG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    Search CenterWatch for drugs/clinical trials and news about KCNG2 

    Transcripts
    for KCNG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KCNG2 gene: 
    NM_012283.1  

    Unigene Cluster for KCNG2:

    Potassium voltage-gated channel, subfamily G, member 2
    Hs.247905
    Unigene Representative Sequence: AK308622
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316249(uc010xfl.2) ENST00000590307

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNG2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KCNG2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG2 (see all 4)
    OriGene shRNA RFP: KCNG2
    OriGene siRNA: KCNG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KCNG2 (NM_012283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNG2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNG2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG2

    Additional cDNA sequence: 

    AJ011021.1 AK308622.1 

    1 DOTS entry:

    DT.91683270 

    2 AceView cDNA sequences:

    NM_012283 AJ011021 

    GeneLoc Exon Structure


    Expression
    for KCNG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KCNG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTTCCCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KCNG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KCNG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KCNG2

    SOURCE GeneReport for Unigene cluster: Hs.247905

    UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96
    Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in
    brain, lung and placenta

        SABiosciences Custom PCR Arrays for KCNG2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNG2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG2
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KCNG2

    Orthologs
    for KCNG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KCNG2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KCNG21 potassium voltage-gated channel, subfamily G, member more 66.04(n)
    69.03(a)    		   395902  NM_205039.1  NP_990370.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KCNG26
    		 --
    		 58(a)
    		 1 ↔ 1
    		 4(53002834-53033171)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR848728.16
    CABZ01045232.16
    		 --
    52(a)
    		 possible ortholog
    1 ↔ 1
    		 2(41838136-41842617)
    19(12129824-12169950)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 24(a)
    		 possible ortholog
    		 Group13.15(957-3745)
    worm
    (Caenorhabditis elegans)    		 Secernentea kvs-36
    kvs-16
    (see all 6)    		 Protein KVS-3
    K (potassium) Voltage-gated Sensory channel subuni...
    (see all 6)    		 29(a)
    23(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 V(9318279-9320971)
    X(7690539-7707035)


    ENSEMBL Gene Tree for KCNG2 (if available)
    TreeFam Gene Tree for KCNG2 (if available) 

    Paralogs
    for KCNG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KCNG2 gene
    KCNG32  KCNF12  KCNB22  KCNV12  KCNS22  KCNS32  KCNB12  KCNV22  
    KCNG42  KCNG12  KCNS12  
    13 SIMAP similar genes for KCNG2 using alignment to 1 protein entry:     KCNG2_HUMAN:
    KCNG1    KCNG4    KCNB1    KCNB2    KCNG3    KCNV2
    KCNS2    KCNF1    KCNS3    KCNS1    KCNV1    KCND3
    KCNA1

    KCNG2 for paralogs           About GeneDecksing



    Genomic Variants
    for KCNG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/962 NCBI SNPs in KCNG2 are shown (see all 962)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1825677991,2
    		--77621668(+) TAGATG/TAATGT 1 -- us2k10--------
    rs47990941,2
    		C,F,H,--77621727(+) TTTCTT/CCCCTG 1 -- us2k1 trp319Minor allele frequency- C:0.27NS EA NA WA 2344
    rs1152322901,2
    		F,--77621816(+) CCGTTT/ATCTTC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1431305221,2
    		--77621922(+) AGACCC/TTCTAA 1 -- us2k10--------
    rs1880389001,2
    		--77622088(+) GAAATA/CTTTTC 1 -- us2k10--------
    rs1511493571,2
    		--77622251(+) CCCCTA/CTCCCC 1 -- us2k10--------
    rs110815691,2
    		C,F,H,--77622356(+) GTTCCA/CATAGC 1 -- us2k129Minor allele frequency- C:0.28NS EA NA WA 3192
    rs110815701,2
    		C,F,--77622376(+) AGCAAG/ATGGTG 1 -- us2k18Minor allele frequency- A:0.28NA WA EA 368
    rs1930773791,2
    		--77622407(+) GTCTGA/GAATGA 1 -- us2k10--------
    rs1158851701,2
    		--77622446(+) TCTGCG/ATGTCT 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for KCNG2 (77623668 - 77660184 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for KCNG2
         7 CNVs: 73233 102753 61656 50060 73234 23551 67421
         6 Indels: 12005 45717 12003 42721 12004 12002

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNG2
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNG2

    Disorders / Diseases
    for KCNG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KCNG2 for disorders           About GeneDecksing

    OMIM gene information: 605696    OMIM disorders: --

    4 diseases for KCNG2:    About MalaCards
    neuronitis    fainting    myocarditis    pharyngitis


    Export disorders for KCNG2 gene to outside databases

    Publications
    for KCNG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KCNG2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KCNG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of Kv6.2, a new gamma- subunit of voltage-gated potassium channel. (PubMed id 10551266)1, 2, 3, 9 Zhu X.-R.... Pongs O. (1999)
    2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)

    External Searches for KCNG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KCNG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26251 HGNC: 6249 AceView: KCNG2 Ensembl:ENSG00000178342 euGenes: HUgn26251
    ECgene: KCNG2 H-InvDB: KCNG2

    Other Databases showing KCNG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KCNG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KCNG2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KCNG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KCNG2 gene:
    Search GeneIP for patents involving KCNG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KCNG2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KCNG2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNG2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNG2  
     OriGene Protein Over-expression Lysate for KCNG2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KCNG2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNG2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KCNG2   OriGene Custom Protein Services for KCNG2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KCNG2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNG2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNG2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNG2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNG2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNG2
     GenScript Custom Purified and Recombinant Proteins Services for KCNG2 GenScript cDNA clones with any tag delivered in your preferred vector for KCNG2
     GenScript Custom Assay Services for KCNG2 GenScript Custom Superior Antibodies Services for KCNG2
     GenScript Custom overexpressing Cell Line Services for KCNG2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNG2 promoter
     Search Chromatin IP Primers for KCNG2
     RT2 qPCR Primer Assay in human, mouse, rat KCNG2
     Search GNC Networks for KCNG2
     SABiosciences PCR Arrays including human, mouse, rat KCNG2
     Tocris compounds for KCNG2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KCNG2 antibodies
     KCNG2 lysates
     Search for Antibodies for KCNG2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KCNG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KCNG2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KCNG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KCNG2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KCNG2
     SwitchGear Promoter luciferase reporter plasmids for KCNG2
     Search ThermoFisher Antibodies for KCNG2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KCNG2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KCNG2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4