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Aliases for KCNG2 Gene

Aliases for KCNG2 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 2 2 3
  • Potassium Voltage-Gated Channel, Subfamily G, Member 2 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.2 3 4
  • Cardiac Potassium Channel Subunit 3 4
  • KCNF2 3 4
  • Potassium Voltage-Gated Channel Subfamily G Member 2 3
  • KV6.2 3

External Ids for KCNG2 Gene

Summaries for KCNG2 Gene

Entrez Gene Summary for KCNG2 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG2 Gene

KCNG2 (Potassium Channel, Voltage Gated Modifier Subfamily G, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNG2 Gene

  • Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values

Tocris Summary for KCNG2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG2 Gene

Genomics for KCNG2 Gene

Genomic Location for KCNG2 Gene

Start:
79,863,668 bp from pter
End:
79,900,184 bp from pter
Size:
36,517 bases
Orientation:
Plus strand

Genomic View for KCNG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG2 Gene

Regulatory Elements for KCNG2 Gene

Proteins for KCNG2 Gene

  • Protein details for KCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ96-KCNG2_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 2
    Protein Accession:
    Q9UJ96
    Secondary Accessions:

    Protein attributes for KCNG2 Gene

    Size:
    466 amino acids
    Molecular mass:
    51240 Da
    Quaternary structure:
    • Heterodimer with KCNB1. Does not form homomultimers
    Miscellaneous:
    • Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone

neXtProt entry for KCNG2 Gene

Proteomics data for KCNG2 Gene at MOPED

Post-translational modifications for KCNG2 Gene

No Post-translational modifications

Other Protein References for KCNG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG2 Gene

Domains for KCNG2 Gene

Gene Families for KCNG2 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNG2_HUMAN
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q9UJ96
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.:
    • Q9UJ96
genes like me logo Genes that share domains with KCNG2: view

Function for KCNG2 Gene

Molecular function for KCNG2 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,subfamily G,member 2,rat Kv6.2 homolog,preferentially expressed in myocard
UniProtKB/Swiss-Prot Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values

Gene Ontology (GO) - Molecular Function for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNG2: view

Phenotypes for KCNG2 Gene

GenomeRNAi human phenotypes for KCNG2:
genes like me logo Genes that share phenotypes with KCNG2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNG2 Gene

Localization for KCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNG2 Gene COMPARTMENTS Subcellular localization image for KCNG2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KCNG2: view

Pathways for KCNG2 Gene

genes like me logo Genes that share pathways with KCNG2: view

Gene Ontology (GO) - Biological Process for KCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 10551266
GO:0007268 synaptic transmission TAS --
GO:0008016 regulation of heart contraction TAS 10551266
genes like me logo Genes that share ontologies with KCNG2: view

Compounds for KCNG2 Gene

(5) Tocris Compounds for KCNG2 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
genes like me logo Genes that share compounds with KCNG2: view

Transcripts for KCNG2 Gene

mRNA/cDNA for KCNG2 Gene

(5) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG2 Gene

No ASD Table

Relevant External Links for KCNG2 Gene

GeneLoc Exon Structure for
KCNG2
ECgene alternative splicing isoforms for
KCNG2

Expression for KCNG2 Gene

mRNA expression in normal human tissues for KCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG2 Gene

This gene is overexpressed in Brain - Hippocampus (8.0) and Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNG2 Gene

SOURCE GeneReport for Unigene cluster for KCNG2 Gene Hs.247905

mRNA Expression by UniProt/SwissProt for KCNG2 Gene

Q9UJ96-KCNG2_HUMAN
Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta
genes like me logo Genes that share expressions with KCNG2: view

Orthologs for KCNG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNG2 36
  • 98.75 (n)
  • 98.58 (a)
KCNG2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNG2 36
  • 91.83 (n)
  • 92.01 (a)
KCNG2 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNG2 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcng2 36
  • 88.86 (n)
  • 91.42 (a)
Kcng2 16
Kcng2 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Kcng2 36
  • 88.56 (n)
  • 92.33 (a)
chicken
(Gallus gallus)
Aves KCNG2 37
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01045232.1 37
  • 52 (a)
ManyToMany
Species with no ortholog for KCNG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG2 Gene

ENSEMBL:
Gene Tree for KCNG2 (if available)
TreeFam:
Gene Tree for KCNG2 (if available)

Paralogs for KCNG2 Gene

Paralogs for KCNG2 Gene

Selected SIMAP similar genes for KCNG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNG2: view

Variants for KCNG2 Gene

Sequence variations from dbSNP and Humsavar for KCNG2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs732039 -- 79,877,612(-) GGAAC(G/T)AGGCT intron-variant
rs732040 -- 79,877,677(-) GTGGG(G/T)GCTCC intron-variant
rs737504 -- 79,900,015(+) GTCAC(C/T)GGCCT downstream-variant-500B
rs891488 -- 79,877,424(+) AGGGA(C/T)GCAGA intron-variant
rs891489 -- 79,877,493(+) GCTGC(A/G)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNG2 Gene

Variant ID Type Subtype PubMed ID
nsv428359 CNV Gain 18775914
nsv910000 CNV Loss 21882294
nsv525694 CNV Loss 19592680
nsv910009 CNV Loss 21882294
nsv910028 CNV Gain 21882294
nsv519406 CNV Gain 19592680
nsv470437 CNV Loss 18288195
nsv910039 CNV Loss 21882294
nsv910040 CNV Loss 21882294
dgv3491n71 CNV Loss 21882294
dgv3492n71 CNV Loss 21882294
nsv910047 CNV Gain 21882294
dgv3493n71 CNV Loss 21882294
nsv469607 CNV Loss 16826518
nsv910058 CNV Loss 21882294
nsv910060 CNV Loss 21882294
nsv509710 CNV Insertion 20534489
nsv910061 CNV Loss 21882294
dgv3494n71 CNV Loss 21882294
esv29216 CNV Gain 19812545
nsv131019 CNV Loss 16902084
esv2672923 CNV Deletion 23128226
nsv130639 CNV Loss 16902084
nsv520750 CNV Loss 19592680
esv2487517 CNV Deletion 19546169
esv23843 CNV Gain 19812545
nsv821139 CNV Deletion 20802225
esv1026680 CNV Deletion 17803354
nsv130646 CNV Loss 16902084
esv4697 CNV Deletion 18987735
esv1002151 CNV Deletion 20482838
esv23902 CNV Loss 19812545
esv2666043 CNV Deletion 23128226
esv2674523 CNV Deletion 23128226
esv2118355 CNV Deletion 18987734
esv1438403 CNV Insertion 17803354
nsv130913 CNV Loss 16902084

Relevant External Links for KCNG2 Gene

HapMap Linkage Disequilibrium report
KCNG2

Disorders for KCNG2 Gene

No disorders were found for KCNG2 Gene.

No data available for UniProtKB/Swiss-Prot for KCNG2 Gene

Publications for KCNG2 Gene

  1. Structural and functional characterization of Kv6.2, a new gamma- subunit of voltage-gated potassium channel. (PMID: 10551266) Zhu X.-R. … Pongs O. (Recept. Channels 1999) 2 3 4 23
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. (PMID: 24143882) Gelernter J. … Farrer L.A. (Biol. Psychiatry 2014) 3

Products for KCNG2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KCNG2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KCNG2
    • Block miRNA regulation of KCNG2 using miScript Target Protectors

    Sources for KCNG2 Gene

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