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Aliases & Descriptions for KCNG2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KCNF2 1, 2, 3 | | KV6.2 2 | | Kv6.2 1 | | OTTHUMP00000041994 2 |
| | | Descriptions |
|---|
| Cardiac potassium channel subunit 2, 3 | | Voltage-gated potassium channel subunit Kv6.2 3 | | potassium voltage-gated channel, subfamily G, member 2 2 |
|
| | Search outside databases for aliases for KCNG2 genePrevious GC identifers: GC18P077138 GC18P077677 GC18P077358 GC18P075722 |
Summaries for KCNG2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNG2: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values |
Genomic Location for KCNG2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNG2 gene 
Entrez Gene cytogenetic band: 18q22-q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23KCNG2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P075724:
(about GC identifiers)
Start:
|
75,724,656 bp from pter |
End:
|
75,760,804 bp from pter |
Size:
|
36,149 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000018.8 NT_010879.15
| Proteins for KCNG2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily G member 2 Size: 466 amino acids; 51240 Da
Subunit: Heterodimer with KCNB1. Does not form homomultimers
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenoneREFSEQ proteins: NP_036415.1
ENSEMBL proteins: ENSP00000315654
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNG2: Assays for KCNG2: | Protein
Domains/ Families for KCNG2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UJ96
ProtoNet protein and cluster: Q9UJ96 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003969 Kv6 potassium channel alpha subunit signature
UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. G subfamily | Gene Function for KCNG2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012283
Applied Biosystems Silencer® siRNAs for KCNG2
Sigma-Aldrich siRNA and siRNA Panels for KCNG2  Sigma-Aldrich shRNA Panels and shRNA for KCNG2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012283                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012283 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012283
UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96Function: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative valuesGenatlas biochemistry entry for KCNG2:potassium voltage-gated channel,subfamily G,member 2,rat Kv6.2 homolog,preferentially expressed in myocard4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KCNG2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/41 Interacting proteins for KCNG2 (ENSP000003156543) via UniProtKB, MINT, and/or STRING (see all 41
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNG2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for KCNG2 |
Compounds for KCNG2 available from Tocris Bioscience About this table
|
Transcripts for KCNG2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012283
Sigma-Aldrich siRNA and siRNA Panels for KCNG2  Sigma-Aldrich shRNA Panels and shRNA for KCNG2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012283 REFSEQ mRNAs for KCNG2 gene: NM_012283.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012283               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012283                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012283                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012283  Additional cDNA sequence: AJ011021.1 AK308622.1 1 DOTS entry: DT.91683270 2 AceView cDNA sequences:AJ011021 NM_012283
highest scoring ESTs for KCNG2:AJ011021 NM_012283 DA104125 Unigene Cluster for KCNG2: Potassium voltage-gated channel, subfamily G, member 2 Hs.247905 Unigene Representative Sequence: AK308622
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000316249
|
Expression for KCNG2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNG2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNG2
1 / 2 / 3 2 probe-sets matching KCNG2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCTTCCCGG
SOURCE GeneReport for Unigene cluster: Hs.247905 UniProtKB/Swiss-Prot: KCNG2_HUMAN, Q9UJ96Tissue specificity: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta |
Orthologs for KCNG2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNG2 gene from 4 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
cow (Bos taurus) |
KCNG21 |
-- |
potassium voltage-gated channel, subfamily G, member more |
91.76(n) 91.68(a) |
506324 XM_582754.3 XP_582754.3 |
rat (Rattus norvegicus) |
Kcng21 |
-- |
potassium voltage-gated channel, subfamily G, member more |
89.56(n) 93.73(a) |
307234 XM_225718.3 XP_225718.3 |
mouse (Mus musculus) |
Kcng21, 5 |
185
|
potassium voltage-gated channel, subfamily G, member more1, 5 |
88.79(n)1 91.42(a)1 |
2404441 XM_140499.71 XP_140499.61 AA5915245 AK1587805 |
chicken (Gallus gallus) |
KCNG21 |
-- |
potassium voltage-gated channel, subfamily G, member more |
66.04(n) 69.03(a) |
395902 NM_205039.1 NP_990370.1 |
About this table Species with no ortholog for KCNG2
ENSEMBL Gene Tree for KCNG2 | Paralogs for KCNG2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNG2 gene
- KCNG32 KCNG42 KCNG12
|
SNPs/Variants for KCNG2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNG2 (up to first 250kb)
|
Disorders & Mutations for KCNG2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605696
|
Medical News for KCNG2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNG2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 2 PubMed articles for KCNG2 gene: |
Search for KCNG2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNG2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNG2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNG2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNG2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNG2:

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| | | | Tocris compounds for KCNG2 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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