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Aliases & Descriptions for KCNG1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases K13 1 , 2 KCNG 2 KH2 5 KV6.1 2 Kv6.1 1 MGC12878 2 OTTHUMP00000043416 2 kH2 1 , 2 , 3
Descriptions Voltage-gated potassium channel subunit Kv6.1 3 potassium channel KH2 2 potassium channel Kv6.1 2 potassium voltage-gated channel, subfamily G, member 1 2
Search outside databases for aliases for KCNG1 genePrevious GC identifers: GC20M049349 GC20M050258 GC20M050305
Summaries for KCNG1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for KCNG1 : Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ionchannels from both functional and structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes amember of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed inskeletal muscle. Multiple alternatively spliced transcript variants have been found in normal andcancerous tissues. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 Function : Probable potassium channel subunit. May need to associate with another protein to form afunctional channel. May modulate channel activity
Gene Wiki entry for KCNG1
Genomic Location for KCNG1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the KCNG1 gene Entrez Gene cytogenetic band: 20q13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13 KCNG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M049053:
(about GC identifiers )
Start:
49,053,600 bp from pter
End:
49,073,082 bp from pter
Size:
19,483 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000020.9 NT_011362.9 Proteins for KCNG1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 (See
protein sequence )Recommended Name: Potassium voltage-gated channel subfamily G member 1 Size : 513 amino acids; 57913 Da
Subunit : Heterotetramer of potassium channel proteins (By similarity)
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : O43528 Q9BRC1Alternative splicing : 2 isoforms : Q9UIX4-1 Q9UIX4-2
REFSEQ proteins (2 alternative transcripts):
NP_002228.2 NP_758529.1 ENSEMBL proteins: ENSP00000360626 ENSP00000379338 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008076 voltage-gated potassium channel complex
IEA -- GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
NAS --
About this table Antibodies for KCNG1: Assays for KCNG1:
Protein
Domains/ Families for KCNG1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UIX4 ProtoNet protein and cluster: Q9UIX4
3 Blocks protein families : IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003969 Kv6 potassium channel alpha subunit signature UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 Domain : The segment S4 is probably the voltage-sensor and is characterized by a series ofpositively charged amino acids at every third position Similarity : Belongs to the potassium channel family. G subfamily
Gene Function for KCNG1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002237 Applied Biosystems Silencer ® siRNAs for KCNG1 Sigma-Aldrich siRNA and siRNA Panels for KCNG1 Sigma-Aldrich shRNA Panels and shRNA for KCNG1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002237                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002237                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002237  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002237 UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 Function : Probable potassium channel subunit. May need to associate with another protein to form afunctional channel. May modulate channel activity
Genatlas biochemistry entry for KCNG1 :potassium voltage-gated channel,subfamily G,member 1,rat IK8 homolog,expressed inbrain,placenta,skeletal muscle with an alternatively spliced from expressed in brain 4 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005244 voltage-gated ion channel activity
IEA -- GO:0005249 voltage-gated potassium channel activity
IEA -- GO:0005515 protein binding
IEA -- GO:0030955 potassium ion binding
IEA --
About this table
Pathways & Interactions for KCNG1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for KCNG1 4 Interacting proteins for KCNG1 (ENSP00000360626 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for KCNG1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for KCNG1 available from Tocris Bioscience About this table
Transcripts for KCNG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_002237 Sigma-Aldrich siRNA and siRNA Panels for KCNG1 Sigma-Aldrich shRNA Panels and shRNA for KCNG1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002237
REFSEQ mRNAs for KCNG1 gene (2 alternative transcripts): NM_002237.3 NM_172318.2 NM_002237
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_002237                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_002237                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_002237  
Additional cDNA sequence: AF033383.1 AK128721.1 AK290689.1 BC006367.1 BC046629.2
8 DOTS entries : DT.40123540 DT.100755364 DT.92421268 DT.97773572 DT.80101975 DT.92421270 DT.120803154 DT.92421269
24/57 AceView cDNA sequences (see all 57
):BQ276383 BX281494 BQ941236 AW236594 CN480356 AW135991 BE672888 BG029104 AI968477 NM_002237 AK128721 NM_172318 BM556621 AU130821 BC046629 AF033383 BF183007 BE389327 AI674491 AW205780 CN484514 BF569197 BG772332 BG491520
highest scoring ESTs for KCNG1 :AW160644 BC006367 BC046629 BE299334 BF308289 BG772332 BI597848 AA115391 AA193556 AA687429
Unigene Cluster for KCNG1: Potassium voltage-gated channel, subfamily G, member 1 Hs.118695 [show with all ESTs ] Unigene Representative Sequence: AK128721 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KCNG1 (see all 7
) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 SP1 :       -                         SP2 :       -                         SP3 :       -   -   -                     SP4 :         -   -                     SP5 :       -   -   -   -             -   -    
About this scheme ECgene alternative splicing isoforms for KCNG1 2 Ensembl transcripts including schematic representations : ENST00000371571
ENST00000396017
Expression for KCNG1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KCNG1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KCNG1 1 / 2 / 3
5 probe-sets matching KCNG1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.118695 Expression variation in blood from EXPOLDB for KCNG1
UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 Tissue specificity : Detected in brain and placenta, and at much lower levels in kidney and pancreas
Orthologs for KCNG1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KCNG1 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
KCNG11
--
potassium voltage-gated channel, subfamily G, member more
93.31(n) 94.15(a)
485929 XM_543053.2 XP_543053.2
chimpanzee (Pan troglodytes)
KCNG11
--
potassium voltage-gated channel, subfamily G, member more
99.68(n) 100(a)
745113 XM_001168547.1 XP_001168547.1
cow (Bos taurus)
KCNG11
--
potassium voltage-gated channel, subfamily G, member more
92.14(n) 94.15(a)
539813 XM_589649.3 XP_589649.1
rat (Rattus norvegicus)
Kcng11
--
potassium voltage-gated channel, subfamily G, member more
86.94(n) 92.59(a)
296395 XM_215951.4 XP_215951.1
mouse (Mus musculus)
Kcng11 , 5
25
potassium voltage-gated channel, subfamily G, member more 1, 5
87.39(n) 1 92.98(a) 1
241794 1 NM_001081134.1 1 NP_001074603.1 1 AI846248 5 AW061031 5 (see all 11 )
About this table Species with no ortholog for KCNG1 ENSEMBL Gene Tree for KCNG1 Paralogs for KCNG1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KCNG1 gene KCNG3 2 KCNG4 2 KCNG2 2
SNPs/Variants for KCNG1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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The following additional 52 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for KCNG1 (up to first 250kb)
Disorders & Mutations for KCNG1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603788
Medical News for KCNG1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KCNG1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for KCNG1 gene : Isolation, characterization, and mapping of two human potassium channels. (PubMed id 9434767) 1, 2, 3, 4 Su K.... Li Y. (1997) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104) 2, 3 Gutman G.A....Wang X. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 3, 4 Deloukas P....Rogers J. (2001) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 3 Brandenberger R.... Stanton L.W. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. (PubMed id 8980147) 3 Post M.A....Brown A.M. (1996)
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Genome Databases showing KCNG1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KCNG1
(According to HUGE )
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--
Specialized Databases showing KCNG1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KCNG1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for KCNG1:
Tocris compounds for KCNG1
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