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Aliases for KCNG1 Gene

Aliases for KCNG1 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily G Member 1 2 3 5
  • Potassium Voltage-Gated Channel, Subfamily G, Member 1 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.1 3 4
  • KH2 3 4
  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 1 3
  • Potassium Voltage-Gated Channel Subfamily G Member 1 3
  • Potassium Channel Kv6.1 3
  • Potassium Channel KH2 3
  • KV6.1 3
  • KCNG 3
  • K13 3

External Ids for KCNG1 Gene

Previous HGNC Symbols for KCNG1 Gene

  • KCNG

Previous GeneCards Identifiers for KCNG1 Gene

  • GC20M049349
  • GC20M050258
  • GC20M050305
  • GC20M049053
  • GC20M049621
  • GC20M046368

Summaries for KCNG1 Gene

Entrez Gene Summary for KCNG1 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG1 Gene

KCNG1 (Potassium Voltage-Gated Channel Modifier Subfamily G Member 1) is a Protein Coding gene. Diseases associated with KCNG1 include X-Linked Disease. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNG4.

UniProtKB/Swiss-Prot for KCNG1 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Tocris Summary for KCNG1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNG1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG1 Gene

Genomics for KCNG1 Gene

Regulatory Elements for KCNG1 Gene

Enhancers for KCNG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F050979 1.7 FANTOM5 Ensembl ENCODE 11.2 +42.0 42041 4.1 ATF1 PKNOX1 SIN3A DMAP1 BRCA1 ZNF48 GLIS2 ZNF143 FOS SP3 DPM1 PTPN1 ENSG00000232043 KCNG1 MOCS3 ENSG00000232358 PIR61443
GH20F050987 1.2 Ensembl ENCODE 11.6 +35.3 35315 0.9 HDGF ELF3 TBP INSM2 ARID4B SIN3A THRB RAD21 ZNF48 RFX5 KCNG1 ENSG00000232358 PIR61443
GH20F051303 1.2 Ensembl ENCODE 11.2 -282.5 -282459 3.5 ARID4B ZNF48 ZNF143 DEK ZNF263 YY2 NFYC MXD4 REST KAT8 KCNG1 DPM1 ENSG00000232043 PSMD10P1 LOC105372663 GC20M051206
GH20F051096 1.1 ENCODE 10.8 -74.2 -74229 2.5 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS SP3 KCNG1 ENSG00000232358 TMEM189 ENSG00000279835
GH20F051326 1.1 FANTOM5 ENCODE 10.6 -304.3 -304281 2.5 SIX4 CTCF KLF1 REST RAD21 ZKSCAN1 ZNF664 TGIF2 JUND CBX1 ENSG00000232358 KCNG1 LOC105372663 GC20M051206
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KCNG1 on UCSC Golden Path with GeneCards custom track

Promoters for KCNG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000402789 276 1401 ELK1 ZNF263 SP3 REST GLIS1 ZBTB33 ZNF24 ZBTB26 MGA CTCF

Genomic Location for KCNG1 Gene

Chromosome:
20
Start:
51,003,656 bp from pter
End:
51,023,176 bp from pter
Size:
19,521 bases
Orientation:
Minus strand

Genomic View for KCNG1 Gene

Genes around KCNG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG1 Gene

Proteins for KCNG1 Gene

  • Protein details for KCNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIX4-KCNG1_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily G member 1
    Protein Accession:
    Q9UIX4
    Secondary Accessions:
    • A8K3S4
    • O43528
    • Q5JXL5
    • Q9BRC1

    Protein attributes for KCNG1 Gene

    Size:
    513 amino acids
    Molecular mass:
    57913 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 (PubMed:19074135).

    Alternative splice isoforms for KCNG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNG1 Gene

Post-translational modifications for KCNG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNG1 Gene

Domains & Families for KCNG1 Gene

Gene Families for KCNG1 Gene

Suggested Antigen Peptide Sequences for KCNG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIX4

UniProtKB/Swiss-Prot:

KCNG1_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
genes like me logo Genes that share domains with KCNG1: view

Function for KCNG1 Gene

Molecular function for KCNG1 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,subfamily G,member 1,rat IK8 homolog,expressed in brain,placenta,skeletal muscle with an alternatively spliced from expressed in brain
UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Gene Ontology (GO) - Molecular Function for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005251 delayed rectifier potassium channel activity IEA,ISS --
GO:0005267 potassium channel activity NAS 9434767
genes like me logo Genes that share ontologies with KCNG1: view

Phenotypes for KCNG1 Gene

genes like me logo Genes that share phenotypes with KCNG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNG1

miRNA for KCNG1 Gene

miRTarBase miRNAs that target KCNG1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNG1 Gene

Localization for KCNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG1 Gene

Cell membrane; Multi-pass membrane protein. Note=Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). {ECO:0000269 PubMed:19074135}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNG1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 colocalizes_with voltage-gated potassium channel complex IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with KCNG1: view

Pathways & Interactions for KCNG1 Gene

genes like me logo Genes that share pathways with KCNG1: view

Pathways by source for KCNG1 Gene

1 Qiagen pathway for KCNG1 Gene

Gene Ontology (GO) - Biological Process for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,NAS 9434767
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNG1: view

No data available for SIGNOR curated interactions for KCNG1 Gene

Drugs & Compounds for KCNG1 Gene

(4) Drugs for KCNG1 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Aminopyridine Approved Pharma Pore Blocker potassium channel-blocking agent, Non-selective KV channel blocker 68
E-4031 dihydrochloride Pharma KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 0
Linopirdine dihydrochloride Pharma KV7 (KCNQ) channel blocker 0
XE 991 dihydrochloride Pharma Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents 0

(1) Additional Compounds for KCNG1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HMR 1556
223749-46-0

(5) Tocris Compounds for KCNG1 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker 504-24-5
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) 113559-13-0
HMR 1556 Potent and selective Iks channel blocker 223749-46-0
Linopirdine dihydrochloride KV7 (KCNQ) channel blocker 113168-57-3
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents 122955-13-9
genes like me logo Genes that share compounds with KCNG1: view

Transcripts for KCNG1 Gene

Unigene Clusters for KCNG1 Gene

Potassium voltage-gated channel, subfamily G, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:

Relevant External Links for KCNG1 Gene

GeneLoc Exon Structure for
KCNG1
ECgene alternative splicing isoforms for
KCNG1

Expression for KCNG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNG1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNG1 Gene

This gene is overexpressed in Uterus (x11.3) and Fallopian Tube (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of KCNG1 Gene:

KCNG1

SOURCE GeneReport for Unigene cluster for KCNG1 Gene:

Hs.118695

mRNA Expression by UniProt/SwissProt for KCNG1 Gene:

Q9UIX4-KCNG1_HUMAN
Tissue specificity: Expressed in brain and placenta, and at much lower levels in kidney and pancreas (PubMed:9434767).
genes like me logo Genes that share expression patterns with KCNG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNG1 Gene

Orthologs for KCNG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNG1 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia KCNG1 34 35
  • 92.92 (n)
cow
(Bos Taurus)
Mammalia KCNG1 34 35
  • 92.14 (n)
mouse
(Mus musculus)
Mammalia Kcng1 34 16 35
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Kcng1 34
  • 86.94 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNG1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNG1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNG1 34 35
  • 72.9 (n)
lizard
(Anolis carolinensis)
Reptilia KCNG1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcng1 34
  • 71.6 (n)
zebrafish
(Danio rerio)
Actinopterygii kcng1 34 35
  • 71.59 (n)
Species where no ortholog for KCNG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG1 Gene

ENSEMBL:
Gene Tree for KCNG1 (if available)
TreeFam:
Gene Tree for KCNG1 (if available)

Paralogs for KCNG1 Gene

Paralogs for KCNG1 Gene

genes like me logo Genes that share paralogs with KCNG1: view

Variants for KCNG1 Gene

Sequence variations from dbSNP and Humsavar for KCNG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1010464 -- 51,017,350(+) GAACA(C/T)ACACA intron-variant, upstream-variant-2KB
rs1054267 -- 51,004,304(-) GGTGG(A/G)CTATG reference, missense
rs1054268 -- 51,004,246(-) AGCAT(A/C)CTGAG reference, synonymous-codon
rs1054269 -- 51,004,168(-) CTCAA(A/G)CAGGA reference, synonymous-codon
rs10626097 -- 51,008,643(+) TTTTT(-/TT)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNG1 Gene

Variant ID Type Subtype PubMed ID
esv32899 CNV gain 17666407
esv33244 CNV gain 17666407
esv33318 CNV gain 17666407
nsv3414 CNV insertion 18451855

Variation tolerance for KCNG1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNG1 Gene

Disorders for KCNG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
x-linked disease
- elite association - COSMIC cancer census association via MalaCards
Search KCNG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNG1
genes like me logo Genes that share disorders with KCNG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNG1 Gene

Publications for KCNG1 Gene

  1. Isolation, characterization, and mapping of two human potassium channels. (PMID: 9434767) Su K. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
  2. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. (PMID: 19074135) Mederos Y Schnitzler M. … Preisig-Muller R. (J. Biol. Chem. 2009) 3 4 64
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for KCNG1 Gene

Sources for KCNG1 Gene

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