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Aliases for KCNG1 Gene

Aliases for KCNG1 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily G, Member 1 2 3
  • KH2 3 4 6
  • Potassium Voltage-Gated Channel, Subfamily G, Member 1 2 3
  • Voltage-Gated Potassium Channel Subunit Kv6.1 3 4
  • Potassium Voltage-Gated Channel Subfamily G Member 1 3
  • Potassium Channel Kv6.1 3
  • Potassium Channel KH2 3
  • KV6.1 3
  • KCNG 3
  • K13 3

External Ids for KCNG1 Gene

Previous Symbols for KCNG1 Gene

  • KCNG

Summaries for KCNG1 Gene

Entrez Gene Summary for KCNG1 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNG1 Gene

KCNG1 (Potassium Channel, Voltage Gated Modifier Subfamily G, Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNG1 Gene

  • Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity

Tocris Summary for KCNG1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNG1 Gene

Genomics for KCNG1 Gene

Genomic Location for KCNG1 Gene

51,003,656 bp from pter
51,023,138 bp from pter
19,483 bases
Minus strand

Genomic View for KCNG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNG1 Gene

Regulatory Elements for KCNG1 Gene

Proteins for KCNG1 Gene

  • Protein details for KCNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium voltage-gated channel subfamily G member 1
    Protein Accession:
    Secondary Accessions:
    • A8K3S4
    • O43528
    • Q5JXL5
    • Q9BRC1

    Protein attributes for KCNG1 Gene

    513 amino acids
    Molecular mass:
    57913 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins.

    Alternative splice isoforms for KCNG1 Gene


neXtProt entry for KCNG1 Gene

Proteomics data for KCNG1 Gene at MOPED

Post-translational modifications for KCNG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNG1 Gene

Domains for KCNG1 Gene

Gene Families for KCNG1 Gene

  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels

Suggested Antigen Peptide Sequences for KCNG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position:
    • Q9UIX4
  • Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.:
    • Q9UIX4
genes like me logo Genes that share domains with KCNG1: view

Function for KCNG1 Gene

Molecular function for KCNG1 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,subfamily G,member 1,rat IK8 homolog,expressed in brain,placenta,skeletal muscle with an alternatively spliced from expressed in brain
UniProtKB/Swiss-Prot Function: Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity

Gene Ontology (GO) - Molecular Function for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity NAS 9434767
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNG1: view

Phenotypes for KCNG1 Gene

GenomeRNAi human phenotypes for KCNG1:
genes like me logo Genes that share phenotypes with KCNG1: view

miRNA for KCNG1 Gene

miRTarBase miRNAs that target KCNG1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNG1 Gene

Localization for KCNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNG1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNG1 Gene COMPARTMENTS Subcellular localization image for KCNG1 gene
Compartment Confidence
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with KCNG1: view

Pathways for KCNG1 Gene

genes like me logo Genes that share pathways with KCNG1: view

Pathways by source for KCNG1 Gene

1 Qiagen pathway for KCNG1 Gene

Gene Ontology (GO) - Biological Process for KCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport NAS 9434767
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNG1: view

Compounds for KCNG1 Gene

(5) Tocris Compounds for KCNG1 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
genes like me logo Genes that share compounds with KCNG1: view

Transcripts for KCNG1 Gene

Unigene Clusters for KCNG1 Gene

Potassium voltage-gated channel, subfamily G, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - - - -

Relevant External Links for KCNG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNG1 Gene

mRNA expression in normal human tissues for KCNG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNG1 Gene

This gene is overexpressed in Uterus (11.3) and Fallopian Tube (4.6).

SOURCE GeneReport for Unigene cluster for KCNG1 Gene Hs.118695

mRNA Expression by UniProt/SwissProt for KCNG1 Gene

Tissue specificity: Detected in brain and placenta, and at much lower levels in kidney and pancreas
genes like me logo Genes that share expressions with KCNG1: view

No data available for Protein expression for KCNG1 Gene

Orthologs for KCNG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNG1 35
  • 99.68 (n)
  • 100 (a)
KCNG1 36
  • 100 (a)
(Bos Taurus)
Mammalia KCNG1 35
  • 92.14 (n)
  • 94.15 (a)
KCNG1 36
  • 94 (a)
(Canis familiaris)
Mammalia KCNG1 35
  • 92.92 (n)
  • 93.57 (a)
KCNG1 36
  • 93 (a)
(Mus musculus)
Mammalia Kcng1 35
  • 87.39 (n)
  • 92.98 (a)
Kcng1 16
Kcng1 36
  • 93 (a)
(Monodelphis domestica)
Mammalia KCNG1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia KCNG1 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Kcng1 35
  • 86.94 (n)
  • 92.59 (a)
(Gallus gallus)
Aves KCNG1 35
  • 72.9 (n)
  • 79.72 (a)
KCNG1 36
  • 79 (a)
(Anolis carolinensis)
Reptilia KCNG1 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcng1 35
  • 71.6 (n)
  • 77.51 (a)
(Danio rerio)
Actinopterygii kcng1 35
  • 71.59 (n)
  • 71.26 (a)
kcng1 36
  • 69 (a)
Species with no ortholog for KCNG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNG1 Gene

Gene Tree for KCNG1 (if available)
Gene Tree for KCNG1 (if available)

Paralogs for KCNG1 Gene

Paralogs for KCNG1 Gene

genes like me logo Genes that share paralogs with KCNG1: view

Variants for KCNG1 Gene

Sequence variations from dbSNP and Humsavar for KCNG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1850 -- 51,003,734(+) TTATT(C/T)GCATG utr-variant-3-prime
rs498318 -- 51,019,345(+) tgttt(C/T)tacaa intron-variant
rs761600 -- 51,006,224(+) CTGCA(C/T)CCCAA intron-variant
rs1010464 -- 51,017,350(+) GAACA(C/T)ACACA intron-variant
rs1054267 -- 51,004,304(-) GGTGG(A/G)CTATG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KCNG1 Gene

Variant ID Type Subtype PubMed ID
nsv912920 CNV Loss 21882294
esv33318 CNV Gain 17666407
esv33244 CNV Gain 17666407
esv32899 CNV Gain 17666407
nsv3414 CNV Insertion 18451855

Relevant External Links for KCNG1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNG1 Gene

Disorders for KCNG1 Gene

(2) University of Copenhagen DISEASES for KCNG1 Gene

genes like me logo Genes that share disorders with KCNG1: view

No data available for UniProtKB/Swiss-Prot for KCNG1 Gene

Publications for KCNG1 Gene

  1. Isolation, characterization, and mapping of two human potassium channels. (PMID: 9434767) Su K. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for KCNG1 Gene

Sources for KCNG1 Gene

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