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KCNG1 Gene

protein-coding   GIFtS: 54

GC20M049053
potassium voltage-gated channel, subfamily G, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KCNG)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
K13 1, 2
KCNG 2
KH2 5
KV6.1 2
Kv6.1 1
MGC12878 2
OTTHUMP00000043416 2
kH2 1, 2, 3
Descriptions
Voltage-gated potassium channel subunit Kv6.1 3
potassium channel KH2 2
potassium channel Kv6.1 2
potassium voltage-gated channel, subfamily G, member 1 2
External Ids
HGNC: 62481
Entrez Gene: 37552
UniProtKB: Q9UIX43
Ensembl: ENSG000000265597
Search outside databases for aliases for KCNG1 gene

Previous GC identifers: GC20M049349 GC20M050258 GC20M050305

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for KCNG1:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion
channels from both functional and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,
epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a
member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in
skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and
cancerous tissues. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
Function: Probable potassium channel subunit. May need to associate with another protein to form a
functional channel. May modulate channel activity

Gene Wiki entry for KCNG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KCNG1 gene  

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

KCNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M049053:     (about GC identifiers)

Start:
49,053,600 bp from pter
End:
49,073,082 bp from pter
Size:
19,483 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.9  NT_011362.9  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 1  
Size: 513 amino acids; 57913 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43528 Q9BRC1
Alternative splicing: 2 isoforms:  Q9UIX4-1   Q9UIX4-2   

REFSEQ proteins (2 alternative transcripts): 
NP_002228.2  NP_758529.1  


ENSEMBL proteins: 
ENSP00000360626 ENSP00000379338 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (KCNG1)
Human Recombinant Proteins from Abnova (KCNG1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008076 voltage-gated potassium channel complex IEA--
GO:0016020 membrane IEA--
GO:0016021 integral to membrane NAS--
About this table

Antibodies for KCNG1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for KCNG1
Browse R&D Systems for Antibodies
Antibodies from Abcam (KCNG1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for KCNG1

Assays for KCNG1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR005821 Ion_trans
 IPR000210 BTB/POZ-like
 IPR011333 BTB/POZ_fold
 IPR003968 K_chnl_volt-dep_Kv
 IPR003131 K_chnl_volt-dep_Kv_tetra


   GeneDecks  KCNG1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9UIX4

ProtoNet protein and cluster: Q9UIX4

3 Blocks protein families:
IPB000210 BTB/POZ domain
IPB003091 Potassium channel signature
IPB003969 Kv6 potassium channel alpha subunit signature


UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of
positively charged amino acids at every third position
Similarity: Belongs to the potassium channel family. G subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002237

              Applied Biosystems Silencer® siRNAs for KCNG1

              Sigma-Aldrich siRNA and siRNA Panels for KCNG1  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for KCNG1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002237
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002237
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002237 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002237

UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
Function: Probable potassium channel subunit. May need to associate with another protein to form a
functional channel. May modulate channel activity

Genatlas biochemistry entry for KCNG1:
potassium voltage-gated channel,subfamily G,member 1,rat IK8 homolog,expressed in
brain,placenta,skeletal muscle with an alternatively spliced from expressed in brain

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity IEA--
GO:0005515 protein binding IEA--
GO:0030955 potassium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  KCNG1 


4 Interacting proteins for KCNG1 (ENSP000003606263) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PCBP2ENSP000003524383STRING (score=.924)
FMR1ENSP000003595063STRING (score=.919)
PCBP1ENSP000003055563STRING (score=.913)
HNRNPKENSP000003654583STRING (score=.887)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport NAS9434767
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Compounds for KCNG1 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener[83440-03-3]
4-AminopyridineK+ channel blocker[504-24-5]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (KCNG1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (KCNG1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002237

              Sigma-Aldrich siRNA and siRNA Panels for KCNG1  
                     Sigma-Aldrich shRNA Panels and shRNA for KCNG1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002237  

REFSEQ mRNAs for KCNG1 gene (2 alternative transcripts): 

NM_002237.3   NM_172318.2   

NM_002237  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002237
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002237
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002237 

Additional cDNA sequence: 

AF033383.1 AK128721.1 AK290689.1 BC006367.1 BC046629.2 

8 DOTS entries:

DT.40123540  DT.100755364  DT.92421268  DT.97773572  DT.80101975  DT.92421270  DT.120803154  DT.92421269 

24/57 AceView cDNA sequences (see all 57 ):

BQ276383 BX281494 BQ941236 AW236594 CN480356 AW135991 BE672888 BG029104 
AI968477 NM_002237 AK128721 NM_172318 BM556621 AU130821 BC046629 AF033383 
BF183007 BE389327 AI674491 AW205780 CN484514 BF569197 BG772332 BG491520 

highest scoring ESTs for KCNG1:

AW160644 BC006367 BC046629 BE299334 BF308289 BG772332 BI597848 AA115391 AA193556 AA687429 

Unigene Cluster for KCNG1:

Potassium voltage-gated channel, subfamily G, member 1
Hs.118695  [show with all ESTs]
Unigene Representative Sequence: AK128721


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KCNG1 (see all 7 )

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7
SP1:                    -                                                                     
SP2:                    -                                                                     
SP3:                    -     -     -                                                         
SP4:                          -     -                                                         
SP5:                    -     -     -     -                                   -     -         

About this scheme

ECgene alternative splicing isoforms for KCNG1

2 Ensembl transcripts including schematic representations:
ENST00000371571  ENST00000396017  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KCNG1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for KCNG1

1 / 2 / 3

5 probe-sets matching KCNG1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37498_at2, 3 U95-A 3 1.00 0.94 1.00 1.00 AL050404 0.20 1.00 0.72 1

211053_at2, 3 U133-A 1 1.00 1.00 -- -- BC006367 0.80 1.00 0.91 1

214595_at2, 3 U133-A 1 1.00 1.00 -- -- AI332979 0.60 1.00 0.82 1

211053_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

214595_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  KCNG1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.118695

Expression variation in blood from EXPOLDB for KCNG1

UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
Tissue specificity: Detected in brain and placenta, and at much lower levels in kidney and pancreas

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for KCNG1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNG11   -- potassium voltage-gated channel, subfamily G, member more 93.31(n)
94.15(a)
485929  XM_543053.2  XP_543053.2 
chimpanzee
(Pan troglodytes)
KCNG11   -- potassium voltage-gated channel, subfamily G, member more 99.68(n)
100(a)
745113  XM_001168547.1  XP_001168547.1 
cow
(Bos taurus)
KCNG11   -- potassium voltage-gated channel, subfamily G, member more 92.14(n)
94.15(a)
539813  XM_589649.3  XP_589649.1 
rat
(Rattus norvegicus)
Kcng11   -- potassium voltage-gated channel, subfamily G, member more 86.94(n)
92.59(a)
296395  XM_215951.4  XP_215951.1 
mouse
(Mus musculus)
Kcng11, 5 25
potassium voltage-gated channel, subfamily G, member more1, 5 87.39(n)1
92.98(a)1
2417941  NM_001081134.11  NP_001074603.11 
 AI8462485  AW0610315  (see all 11)
About this table        Species with no ortholog for KCNG1

ENSEMBL Gene Tree for KCNG1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for KCNG1 gene
KCNG32  KCNG42  KCNG22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


8 NCBI SNPs in KCNG1 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs60209191,2
A,F,H49073584(+) AAAACC/GCCACT 1 -- ng316Minor allele frequency- G:0.41EU EA WA MN 774
--
rs60209201,2
--49073911(+) AATTCC/GTAGGG 1 -- ng310--------
--
rs673702051,2
--49075061(+) GAAAT-/TTTTTTT 1 -- ng310--------
--
rs732748311,2
--49075036(+) CAGGCC/TTCTGC 1 -- ng310--------
--
rs351923441,2
--49074803(+) CATGG-/TAGCCC 1 -- ng310--------
--
rs732748301,2
--49073959(+) CCGCGA/GGGCCG 1 -- ng310--------
--
rs732748281,2
--49073819(+) TCGCGC/TGCCTT 1 -- ng310--------
--
rs739098861,2
--49074665(+) GACCTA/GTTTCC 1 -- ng310--------
About this table
The following additional 52 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs6122992 rs540761 rs6013054 rs6020909 rs16995678 rs11904901 rs6020922
 rs6091248 rs6020913 rs34416332 rs911018 rs6126138 rs16995676 rs8118905
 rs6020900 rs1473714 rs4811111 rs4811110 rs17789068 rs6126137 rs6091253
 rs11697989 rs6020905 rs1054269 rs6126139 rs6126147 rs11699706 rs6067608
 rs6122991 rs6096227 rs6020912 rs1010464 rs34965247 rs13041974 rs13042521
 rs6020911 rs17727099 rs4811113 rs1570009 rs6013053 rs4811106 rs6122993
 rs6020902 rs1054267 rs4809820 rs6096234 rs761600 rs1040771 rs1850
 rs6020901 rs6020899 rs6126140

HapMap Linkage Disequilibrium images for KCNG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603788

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for KCNG1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3755 HGNC: 6248 AceView: KCNG1 Ensembl:ENSG00000026559 euGenes: HUgn3755
ECgene: KCNG1 H-InvDB: KCNG1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for KCNG1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for KCNG1-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for KCNG1 Antibodies for KCNG1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KCNG1 Browse small molecules at Sigma-Aldrich
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for KCNG1

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