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KCNG1 Gene

protein-coding   GIFtS: 58
GCID: GC20M049621

Potassium Voltage-Gated Channel, Subfamily G, Member 1


(Previous symbol: KCNG)
  Search for KCNG1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Potassium Voltage-Gated Channel, Subfamily G, Member 11 2     KV6.12
KCNG1 2     Potassium Channel KH22
Voltage-Gated Potassium Channel Subunit Kv6.12 3     Potassium Channel Kv6.12
kH22 3     Potassium Voltage-Gated Channel Subfamily G Member 12
K132     KH25

External Ids:    HGNC: 62481   Entrez Gene: 37552   Ensembl: ENSG000000265597   OMIM: 6037885   UniProtKB: Q9UIX43   

Export aliases for KCNG1 gene to outside databases

Previous GC identifers: GC20M049349 GC20M050258 GC20M050305 GC20M049053 GC20M046368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNG1 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is
abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in
normal and cancerous tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNG1 Gene:
KCNG1 (potassium voltage-gated channel, subfamily G, member 1) is a protein-coding gene. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel activity. An important paralog of this gene is KCNF1.

UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
Function: Probable potassium channel subunit. May need to associate with another protein to form a functional
channel. May modulate channel activity

summary for KCNG1 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNG1 gene promoter:
         TBP   MIF-1   C/EBPalpha   E47   N-Myc   MEF-2A   E2F-1   E2F   Hand1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNG1 promoter sequence
   Search Chromatin IP Primers for KCNG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

KCNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M049621:  view genomic region     (about GC identifiers)

Start:
49,620,193 bp from pter      End:
49,639,675 bp from pter
Size:
19,483 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily G member 1  
Size: 513 amino acids; 57913 Da
Subunit: Heterotetramer of potassium channel proteins (By similarity)
Secondary accessions: A8K3S4 O43528 Q5JXL5 Q9BRC1
Alternative splicing: 2 isoforms:  Q9UIX4-1   Q9UIX4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KCNG1: NX_Q9UIX4

Explore proteomics data for KCNG1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KCNG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002228.2  
    ENSEMBL proteins: 
     ENSP00000360626   ENSP00000394075   ENSP00000394093   ENSP00000408116   ENSP00000396058  
     ENSP00000379338  
    Reactome Protein details: Q9UIX4

    KCNG1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels
    Kv: Voltage-gated ion channels / Potassium channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: Kv6.1
    Voltage-gated potassium channels

    Selected InterPro protein domains (see all 9):
     IPR005821 Ion_trans_dom
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR027359 Channel_four-helix_dom
     IPR028325 VG_K_chnl

    Graphical View of Domain Structure for InterPro Entry Q9UIX4

    ProtoNet protein and cluster: Q9UIX4

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB003091 Potassium channel signature
    IPB003969 Kv6 potassium channel alpha subunit signature


    UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily


    Find genes that share domains with KCNG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNG1_HUMAN, Q9UIX4
    Function: Probable potassium channel subunit. May need to associate with another protein to form a functional
    channel. May modulate channel activity

         Genatlas biochemistry entry for KCNG1:
    potassium voltage-gated channel,subfamily G,member 1,rat IK8 homolog,expressed in brain,placenta,skeletal muscle
    with an alternatively spliced from expressed in brain

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005249voltage-gated potassium channel activity ----
    GO:0005251delayed rectifier potassium channel activity IBA--
    GO:0005267potassium channel activity NAS9434767
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KCNG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KCNG1:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNG1
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    miRNA
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    miRTarBase miRNAs that target KCNG1:
    hsa-mir-324-5p (MIRT043216)

    Block miRNA regulation of human, mouse, rat KCNG1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KCNG1:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): KCNG1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNG1_HUMAN, Q9UIX4: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008076voltage-gated potassium channel complex IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with KCNG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium Channels
    Potassium Channels0.43
    Voltage gated Potassium channels0.43
    2Transmission across Chemical Synapses
    Neuronal System0.68
    3Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Find genes that share SuperPaths with KCNG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNG1
        Dopamine-DARPP32 Feedback onto cAMP Pathway

    1 Reactome Pathway for KCNG1
        Voltage gated Potassium channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNG1
    Interactions:

        GeneGlobe Interaction Network for KCNG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KCNG1 (Q9UIX43 ENSP000003606264) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNB1Q147213, ENSP000003608064I2D: score=1 STRING: ENSP00000360806
    KCNA10ENSP000003587864STRING: ENSP00000358786
    KCNA2ENSP000003145204STRING: ENSP00000314520
    KCNA3ENSP000003587844STRING: ENSP00000358784
    KCNA4ENSP000003285114STRING: ENSP00000328511
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006813potassium ion transport NAS9434767
    GO:0007268synaptic transmission TAS--
    GO:0051260protein homooligomerization IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with KCNG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for KCNG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNG1 gene (2 alternative transcripts): 
    NM_002237.3  NM_172318.2  

    Unigene Cluster for KCNG1:

    Potassium voltage-gated channel, subfamily G, member 1
    Hs.118695  [show with all ESTs]
    Unigene Representative Sequence: AK128721
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371571(uc002xwa.4) ENST00000506387 ENST00000439216 ENST00000424171
    ENST00000433903 ENST00000447736 ENST00000396017(uc002xwb.3)
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    1 qRT-PCR Assays for microRNA that regulate KCNG1:
    hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): KCNG1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF033383.1 AK128721.1 AK290689.1 BC006367.1 BC046629.2 

    8 DOTS entries:

    DT.40123540  DT.100755364  DT.97773572  DT.92421268  DT.80101975  DT.92421270  DT.120803154  DT.92421269 

    Selected AceView cDNA sequences (see all 57):

    BE672888 CN480356 BG029104 BX281494 AW236594 AI968477 NM_002237 BQ941236 
    AW135991 BQ276383 AF033383 BC046629 BI491647 BI597848 BF057007 BC006367 
    CA488240 AI674491 AU130821 BF569197 CN484514 AW205780 AA960807 BG491520 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KCNG1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7
    SP1:                    -                                                                     
    SP2:                    -                                                                     
    SP3:                    -     -     -                                                         
    SP4:                          -     -                                                         
    SP5:                    -     -     -     -                                   -     -         


    ECgene alternative splicing isoforms for KCNG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KCNG1 Expression
    About this image


    KCNG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
             Umbilical cord blood-derived mesenchymal stem cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    KCNG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118695

    UniProtKB/Swiss-Prot: KCNG1_HUMAN, Q9UIX4
    Tissue specificity: Detected in brain and placenta, and at much lower levels in kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNG1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcng11 , 5 potassium voltage-gated channel, subfamily G, member more1, 5 87.39(n)1
    92.98(a)1
      2 (88.55 cM)5
    2417941  NM_001081134.11  NP_001074603.11 
     1682601175 
    chicken
    (Gallus gallus)
    Aves KCNG11 potassium voltage-gated channel, subfamily G, member more 72.9(n)
    79.72(a)
      419347  XM_004947260.1  XP_004947317.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNG16
    potassium voltage-gated channel, subfamily G, memb...
    78(a)
    1 ↔ 1
    GL343226.1(1970653-1990130)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcng11 potassium voltage-gated channel, subfamily G, member more 71.6(n)
    77.51(a)
      100125206  NM_001103205.1  NP_001096675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcng11 potassium voltage-gated channel, subfamily G, member more 71.59(n)
    71.26(a)
      796774  NM_001110410.1  NP_001103880.1 


    ENSEMBL Gene Tree for KCNG1 (if available)
    TreeFam Gene Tree for KCNG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNG1 gene
    KCNF12  KCNG32  KCNB22  KCNV12  KCNG22  KCNS22  KCNS32  KCNB12  
    KCNV22  KCNG42  KCNS12  
    Selected SIMAP similar genes for KCNG1 using alignment to 5 protein entries:     KCNG1_HUMAN (see all proteins) (see all similar genes):
    KCNG4    KCNG2    KCNB1    KCNB2    KCNG3    KCNS2
    KCNS3    KCNS1    KCNV1    KCNV2    KCNF1    KCND3
    KCND1    KCND2    KCNC2    KCNA1    KCNA2    KCNC1

    Find genes that share paralogs with KCNG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNG1 (see all 457)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790465561,2
    F--49619731(+) ACATGA/TTTTTT 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1883905461,2
    --49619750(+) AAATGA/GACTGA 1 -- int10--------
    rs1455892821,2
    --49619928(+) CAGAGG/TGGGGG 1 -- int10--------
    rs1165360401,2
    F--49619949(+) AGAAAC/TGAGAG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs60130541,2
    C,F,H--49619986(+) TTCCTA/TAAAGT 1 -- int124Minor allele frequency- T:0.18NS EA NA WA CSA 1353
    rs48111091,2
    C,F,A,H--49620119(+) TAAGAG/CAGCCC 1 -- int112Minor allele frequency- C:0.25NA WA CSA EA 375
    rs1380783241,2
    --49620133(+) GGAAGA/GCATTC 1 -- int10--------
    rs2002517111,2
    C--49620227(-) CTGGAA/GAAAAA 1 -- ut310--------
    rs18501,2
    C,F,A,H--49620271(+) TTATTT/CGCATG 1 -- ut3131Minor allele frequency- C:0.26MN NS EA NA WA CSA 3292
    rs119050781,2
    H--49620278(+) CATGGG/TGAAAA 1 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for KCNG1 (49620193 - 49639675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KCNG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3414CNV Insertion18451855
    nsv912920CNV Loss21882294
    esv33244CNV Gain17666407
    esv32899CNV Gain17666407
    esv33318CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNG1
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603788    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for KCNG1:
    Fragile X syndrome     Intellectual disability

    Find genes that share disorders with KCNG1           About GenesLikeMe


    Export disorders for KCNG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNG1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with KCNG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping of two human potassium channels. (PubMed id 9434767)1, 2, 3, 9 Su K.... Li Y. (Biochem. Biophys. Res. Commun. 1997)
    2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (Pharmacol. Rev. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). (PubMed id 23918034)1 KA1hnisch J.... . (Clin Oral Investig 2014)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3755 HGNC: 6248 AceView: KCNG1 Ensembl:ENSG00000026559 euGenes: HUgn3755
    ECgene: KCNG1 H-InvDB: KCNG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KCNG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNG1 gene:
    Search GeneIP for patents involving KCNG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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