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Aliases & Descriptions for KCNF1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| IK8 1, 2 | | KCNF 2 | | KH1 5 | | KV5.1 2 | | Kv5.1 1 | | MGC33316 2 | | kH1 1, 2, 3 |
| | | Descriptions |
|---|
| Voltage-gated potassium channel subunit Kv5.1 3 | | potassium channel KH1 2 | | potassium channel Kv5.1 2 | | potassium voltage-gated channel, subfamily F, member 1 2 |
|
| | Search outside databases for aliases for KCNF1 genePrevious GC identifers: GC02P010837 GC02P011103 GC02P011073 |
Summaries for KCNF1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNF1: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNF1_HUMAN, Q9H3M0Function: Putative voltage-gated potassium channel |
Genomic Location for KCNF1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNF1 gene 
Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25KCNF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P011002:
(about GC identifiers)
Start:
|
10,969,514 bp from pter |
End:
|
10,971,802 bp from pter |
Size:
|
2,289 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005334.15
| Proteins for KCNF1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNF1_HUMAN, Q9H3M0 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily F member 1 Size: 494 amino acids; 55584 Da
Subunit: Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O43527Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002227.2
ENSEMBL proteins: ENSP00000295082
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for KCNF1: Assays for KCNF1: | Protein
Domains/ Families for KCNF1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H3M0
ProtoNet protein and cluster: Q9H3M0 3 Blocks protein families: IPB000210 BTB/POZ domain IPB003091 Potassium channel signature IPB003971 Kv9 potassium channel alpha subunit signature
UniProtKB/Swiss-Prot: KCNF1_HUMAN, Q9H3M0Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third positionSimilarity: Belongs to the potassium channel family. F subfamily | Gene Function for KCNF1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002236
Applied Biosystems Silencer® siRNAs for KCNF1
Sigma-Aldrich siRNA and siRNA Panels for KCNF1  Sigma-Aldrich shRNA Panels and shRNA for KCNF1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002236                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002236                                  untagged cDNA clone in CMV expression vector: NM_002236 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002236
UniProtKB/Swiss-Prot: KCNF1_HUMAN, Q9H3M0Function: Putative voltage-gated potassium channelGenatlas biochemistry entry for KCNF1:potassium voltage-gated channel,subfamily G,member 2,rat K13 homolog,expressed in brain,placenta,skeletal muscle with an alternatively spliced isoform,also expressed in skeletal muscle1 MGI phenotypic allele for Kcnf1 (no phenotypes)
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNF1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNF1 
--2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for KCNF1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNF1 available from Tocris Bioscience About this table
|
Transcripts for KCNF1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002236
Sigma-Aldrich siRNA and siRNA Panels for KCNF1  Sigma-Aldrich shRNA Panels and shRNA for KCNF1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002236 REFSEQ mRNAs for KCNF1 gene: NM_002236.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002236               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002236                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002236                                  untagged cDNA clone in CMV expression vector: NM_002236  Additional cDNA sequence: AF029780.1 AF033382.1 BC026110.2 3 DOTS entries: DT.110435 DT.100745018 DT.92416967 24/25 AceView cDNA sequences (see all 25
):AI274992 NM_002236 AF029780 BF516107 Z38223 AI942483 AI361583 CB054271 AF033382 BG708997 CB054272 BC026110 F04496 BM714346 AA316752 BV183403 BI757855 BQ613980 AA984726 BQ549847 R21482 R45529 F05186 CB155571
highest scoring ESTs for KCNF1:AF033382 AA316752 AA984726 AF029780 AI274992 AI361583 BC026110 BF516107 BG708997 BI757855 Unigene Cluster for KCNF1: Potassium voltage-gated channel, subfamily F, member 1 Hs.23735 [show with all ESTs]Unigene Representative Sequence: BC026110
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000295082
|
Expression for KCNF1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNF1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNF1
1 / 2 / 3 3 probe-sets matching KCNF1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCATCGACAG
SOURCE GeneReport for Unigene cluster: Hs.23735
Expression variation in blood from EXPOLDB for KCNF1 UniProtKB/Swiss-Prot: KCNF1_HUMAN, Q9H3M0Tissue specificity: Detected in heart, brain, liver, skeletal muscle, kidney and pancreas |
Orthologs for KCNF1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNF1 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNF11 |
-- |
potassium voltage-gated channel, subfamily F, member more |
93.93(n) 96.15(a) |
482968 XM_540081.1 XP_540081.1 |
cow (Bos taurus) |
KCNF11 |
-- |
potassium voltage-gated channel, subfamily F, member more |
92.38(n) 96.56(a) |
505879 XM_582243.3 XP_582243.2 |
rat (Rattus norvegicus) |
Kcnf11 |
-- |
potassium voltage-gated channel, subfamily F, member more |
88.91(n) 96.55(a) |
298908 XM_216678.4 XP_216678.4 |
mouse (Mus musculus) |
Kcnf11, 5 |
125
|
potassium voltage-gated channel, subfamily F, member more1, 5 |
89.45(n)1 96.55(a)1 |
3825711 NM_201531.21 NP_963289.11 AI6423215 AK1373675 (see all 9) |
chicken (Gallus gallus) |
KCNF11 |
-- |
potassium voltage-gated channel, subfamily F, member more |
75.86(n) 85.8(a) |
428652 XM_426210.2 XP_426210.2 |
About this table Species with no ortholog for KCNF1
ENSEMBL Gene Tree for KCNF1 | Paralogs for KCNF1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KCNF1 gene
- KCNV22
|
SNPs/Variants for KCNF1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNF1 (up to first 250kb)
|
Disorders & Mutations for KCNF1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603787
|
Medical News for KCNF1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNF1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for KCNF1 gene:- Isolation, characterization, and mapping of two human potassium channels. (PubMed id 9434767)1, 2, 3, 4 Su K.... Li Y. (1997)
- International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)2, 3 Gutman G.A....Wang X. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. (PubMed id 12445884)4 Godreau D....Hatem S.N. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. (PubMed id 12060745)3 Ottschytsch N.... Snyders D.J. (2002)
- Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. (PubMed id 16815889)1 Fantozzi I....Yuan J.X. (2006)
|
Search for KCNF1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNF1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNF1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNF1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNF1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNF1:

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|
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| | | | Tocris compounds for KCNF1 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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