Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCNF1 Gene

Aliases for KCNF1 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily F Member 1 2 3
  • Potassium Channel, Voltage Gated Modifier Subfamily F, Member 1 3 5
  • Potassium Voltage-Gated Channel, Subfamily F, Member 1 2 3
  • Potassium Channel, Voltage Gated Subfamily F, Member 1 2 3
  • Voltage-Gated Potassium Channel Subunit Kv5.1 3 4
  • KH1 3 4
  • Potassium Channel Kv5.1 3
  • Potassium Channel KH1 3
  • KV5.1 3
  • KCNF 3
  • IK8 3

External Ids for KCNF1 Gene

Previous HGNC Symbols for KCNF1 Gene

  • KCNF

Previous GeneCards Identifiers for KCNF1 Gene

  • GC02P010837
  • GC02P011103
  • GC02P011073
  • GC02P011002
  • GC02P010969
  • GC02P011052

Summaries for KCNF1 Gene

Entrez Gene Summary for KCNF1 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNF1 Gene

KCNF1 (Potassium Voltage-Gated Channel Modifier Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNB1.

UniProtKB/Swiss-Prot for KCNF1 Gene

  • Putative voltage-gated potassium channel.

Tocris Summary for KCNF1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNF1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNF1 Gene

Genomics for KCNF1 Gene

Regulatory Elements for KCNF1 Gene

Enhancers for KCNF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNF1 on UCSC Golden Path with GeneCards custom track

Promoters for KCNF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNF1 Gene

10,911,937 bp from pter
10,914,225 bp from pter
2,289 bases
Plus strand

Genomic View for KCNF1 Gene

Genes around KCNF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNF1 Gene

Proteins for KCNF1 Gene

  • Protein details for KCNF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium voltage-gated channel subfamily F member 1
    Protein Accession:
    Secondary Accessions:
    • O43527
    • Q585L3

    Protein attributes for KCNF1 Gene

    494 amino acids
    Molecular mass:
    55584 Da
    Quaternary structure:
    • Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1.

neXtProt entry for KCNF1 Gene

Proteomics data for KCNF1 Gene at MOPED

Post-translational modifications for KCNF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNF1 Gene

Domains & Families for KCNF1 Gene

Gene Families for KCNF1 Gene

Suggested Antigen Peptide Sequences for KCNF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.
genes like me logo Genes that share domains with KCNF1: view

Function for KCNF1 Gene

Molecular function for KCNF1 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,subfamily G,member 2,rat K13 homolog,expressed in brain,placenta,skeletal muscle with an alternatively spliced isoform,also expressed in skeletal muscle
UniProtKB/Swiss-Prot Function:
Putative voltage-gated potassium channel.
genes like me logo Genes that share phenotypes with KCNF1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNF1

miRNA for KCNF1 Gene

miRTarBase miRNAs that target KCNF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNF1 Gene

Localization for KCNF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNF1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNF1 Gene COMPARTMENTS Subcellular localization image for KCNF1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KCNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with KCNF1: view

Pathways & Interactions for KCNF1 Gene

genes like me logo Genes that share pathways with KCNF1: view

Pathways by source for KCNF1 Gene

1 Qiagen pathway for KCNF1 Gene

Gene Ontology (GO) - Biological Process for KCNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNF1: view

No data available for SIGNOR curated interactions for KCNF1 Gene

Drugs & Compounds for KCNF1 Gene

(1) Drugs for KCNF1 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNF1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NS 1643
NS 5806
PD 118057

(5) Tocris Compounds for KCNF1 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNF1: view

Transcripts for KCNF1 Gene

mRNA/cDNA for KCNF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNF1 Gene

Potassium voltage-gated channel, subfamily F, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNF1 Gene

No ASD Table

Relevant External Links for KCNF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNF1 Gene

mRNA expression in normal human tissues for KCNF1 Gene

mRNA differential expression in normal tissues according to GTEx for KCNF1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.6), Brain - Cortex (x7.5), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Frontal Cortex (BA9) (x5.7), Brain - Caudate (basal ganglia) (x5.5), and Brain - Anterior cingulate cortex (BA24) (x5.3).

SOURCE GeneReport for Unigene cluster for KCNF1 Gene Hs.23735

mRNA Expression by UniProt/SwissProt for KCNF1 Gene

Tissue specificity: Detected in heart, brain, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with KCNF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNF1 Gene

Orthologs for KCNF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNF1 35
  • 92.38 (n)
  • 96.56 (a)
KCNF1 36
  • 96 (a)
(Canis familiaris)
Mammalia KCNF1 35
  • 93.93 (n)
  • 96.15 (a)
KCNF1 36
  • 95 (a)
(Mus musculus)
Mammalia Kcnf1 35
  • 89.45 (n)
  • 96.55 (a)
Kcnf1 16
Kcnf1 36
  • 94 (a)
(Pan troglodytes)
Mammalia KCNF1 35
  • 95.37 (n)
  • 94.27 (a)
KCNF1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Kcnf1 35
  • 88.91 (n)
  • 96.55 (a)
(Monodelphis domestica)
Mammalia KCNF1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia KCNF1 36
  • 86 (a)
(Gallus gallus)
Aves KCNF1 35
  • 75.86 (n)
  • 85.8 (a)
KCNF1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia KCNF1 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnf1 35
  • 72.93 (n)
  • 79.96 (a)
(Danio rerio)
Actinopterygii kcnf1b 35
  • 71.38 (n)
  • 74.95 (a)
kcnf1a 36
  • 64 (a)
kcnf1b 36
  • 72 (a)
(Caenorhabditis elegans)
Secernentea C32C4.1 37
  • 33 (a)
exp-2 37
  • 38 (a)
F44A2.2 37
  • 32 (a)
Y48A6B.6 37
  • 33 (a)
C32C4.1 36
  • 25 (a)
exp-2 36
  • 29 (a)
kvs-1 36
  • 26 (a)
kvs-3 36
  • 31 (a)
kvs-4 36
  • 26 (a)
kvs-5 36
  • 21 (a)
Species with no ortholog for KCNF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNF1 Gene

Gene Tree for KCNF1 (if available)
Gene Tree for KCNF1 (if available)

Paralogs for KCNF1 Gene

Paralogs for KCNF1 Gene

(21) SIMAP similar genes for KCNF1 Gene using alignment to 1 proteins: Pseudogenes for KCNF1 Gene

genes like me logo Genes that share paralogs with KCNF1: view

Variants for KCNF1 Gene

Sequence variations from dbSNP and Humsavar for KCNF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1046004 -- 10,913,493(+) TAAGA(A/G)CATCC reference, missense
rs1046005 -- 10,913,573(+) CGCTG(A/G)GCAAG reference, missense
rs3732104 -- 10,912,894(+) GACGC(A/G)GCCGA reference, synonymous-codon
rs3732105 -- 10,913,614(+) GTCAT(C/T)GCCAT reference, synonymous-codon
rs34106012 -- 10,910,010(+) ACCTA(-/A)GGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KCNF1 Gene

Variant ID Type Subtype PubMed ID
nsv873662 CNV Loss 21882294
nsv521177 CNV Loss 19592680

Variation tolerance for KCNF1 Gene

Residual Variation Intolerance Score: 8.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KCNF1 Gene

Disorders for KCNF1 Gene

Relevant External Links for KCNF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KCNF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNF1 Gene

Publications for KCNF1 Gene

  1. Isolation, characterization, and mapping of two human potassium channels. (PMID: 9434767) Su K. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  3. MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. (PMID: 23840749) Petko J. … Levenson R. (PLoS ONE 2013) 3
  4. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. (PMID: 16815889) Fantozzi I. … Yuan J.X. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for KCNF1 Gene

Sources for KCNF1 Gene