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Aliases for KCNF1 Gene

Aliases for KCNF1 Gene

  • Potassium Channel, Voltage Gated Modifier Subfamily F, Member 1 2 3
  • KH1 3 4 6
  • Potassium Voltage-Gated Channel, Subfamily F, Member 1 2 3
  • Potassium Channel, Voltage Gated Subfamily F, Member 1 2 3
  • Voltage-Gated Potassium Channel Subunit Kv5.1 3 4
  • Potassium Voltage-Gated Channel Subfamily F Member 1 3
  • Potassium Channel Kv5.1 3
  • Potassium Channel KH1 3
  • KV5.1 3
  • KCNF 3
  • IK8 3

External Ids for KCNF1 Gene

Previous HGNC Symbols for KCNF1 Gene

  • KCNF

Previous GeneCards Identifiers for KCNF1 Gene

  • GC02P010837
  • GC02P011103
  • GC02P011073
  • GC02P011002
  • GC02P010969
  • GC02P011052

Summaries for KCNF1 Gene

Entrez Gene Summary for KCNF1 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNF1 Gene

KCNF1 (Potassium Channel, Voltage Gated Modifier Subfamily F, Member 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity and potassium channel activity. An important paralog of this gene is KCNB2.

UniProtKB/Swiss-Prot for KCNF1 Gene

  • Putative voltage-gated potassium channel

Tocris Summary for KCNF1 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNF1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNF1 Gene

Genomics for KCNF1 Gene

Regulatory Elements for KCNF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNF1 Gene

Start:
10,911,937 bp from pter
End:
10,914,225 bp from pter
Size:
2,289 bases
Orientation:
Plus strand

Genomic View for KCNF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNF1 Gene

Proteins for KCNF1 Gene

  • Protein details for KCNF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3M0-KCNF1_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily F member 1
    Protein Accession:
    Q9H3M0
    Secondary Accessions:
    • O43527
    • Q585L3

    Protein attributes for KCNF1 Gene

    Size:
    494 amino acids
    Molecular mass:
    55584 Da
    Quaternary structure:
    • Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1.

neXtProt entry for KCNF1 Gene

Proteomics data for KCNF1 Gene at MOPED

Post-translational modifications for KCNF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNF1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNF1 Gene

Domains for KCNF1 Gene

Gene Families for KCNF1 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3M0

UniProtKB/Swiss-Prot:

KCNF1_HUMAN :
  • Q9H3M0
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
Family:
  • Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily.
genes like me logo Genes that share domains with KCNF1: view

Function for KCNF1 Gene

Molecular function for KCNF1 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,subfamily G,member 2,rat K13 homolog,expressed in brain,placenta,skeletal muscle with an alternatively spliced isoform,also expressed in skeletal muscle
UniProtKB/Swiss-Prot Function: Putative voltage-gated potassium channel

Gene Ontology (GO) - Molecular Function for KCNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005267 potassium channel activity TAS 9434767
genes like me logo Genes that share ontologies with KCNF1: view

Phenotypes for KCNF1 Gene

GenomeRNAi human phenotypes for KCNF1:
genes like me logo Genes that share phenotypes with KCNF1: view

Animal Model Products

CRISPR Products

miRNA for KCNF1 Gene

miRTarBase miRNAs that target KCNF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KCNF1 Gene

Localization for KCNF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNF1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNF1 Gene COMPARTMENTS Subcellular localization image for KCNF1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KCNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNF1: view

Pathways for KCNF1 Gene

genes like me logo Genes that share pathways with KCNF1: view

Pathways by source for KCNF1 Gene

1 Qiagen pathway for KCNF1 Gene

Gene Ontology (GO) - Biological Process for KCNF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006813 potassium ion transport TAS 9434767
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCNF1: view

Compounds for KCNF1 Gene

(5) Tocris Compounds for KCNF1 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]
genes like me logo Genes that share compounds with KCNF1: view

Transcripts for KCNF1 Gene

mRNA/cDNA for KCNF1 Gene

(25) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNF1 Gene

Potassium voltage-gated channel, subfamily F, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNF1 Gene

No ASD Table

Relevant External Links for KCNF1 Gene

GeneLoc Exon Structure for
KCNF1
ECgene alternative splicing isoforms for
KCNF1

Expression for KCNF1 Gene

mRNA expression in normal human tissues for KCNF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNF1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (7.6), Brain - Cortex (7.5), Brain - Nucleus accumbens (basal ganglia) (6.1), Brain - Frontal Cortex (BA9) (5.7), Brain - Caudate (basal ganglia) (5.5), and Brain - Anterior cingulate cortex (BA24) (5.3).

SOURCE GeneReport for Unigene cluster for KCNF1 Gene Hs.23735

mRNA Expression by UniProt/SwissProt for KCNF1 Gene

Q9H3M0-KCNF1_HUMAN
Tissue specificity: Detected in heart, brain, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with KCNF1: view

In Situ Assay Products

No data available for Protein expression for KCNF1 Gene

Orthologs for KCNF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNF1 35
  • 95.37 (n)
  • 94.27 (a)
KCNF1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNF1 35
  • 92.38 (n)
  • 96.56 (a)
KCNF1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNF1 35
  • 93.93 (n)
  • 96.15 (a)
KCNF1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnf1 35
  • 89.45 (n)
  • 96.55 (a)
Kcnf1 16
Kcnf1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNF1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNF1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcnf1 35
  • 88.91 (n)
  • 96.55 (a)
chicken
(Gallus gallus)
Aves KCNF1 35
  • 75.86 (n)
  • 85.8 (a)
KCNF1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNF1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnf1 35
  • 72.93 (n)
  • 79.96 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnf1a 36
  • 64 (a)
OneToMany
kcnf1b 35
  • 71.38 (n)
  • 74.95 (a)
kcnf1b 36
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C32C4.1 36
  • 25 (a)
OneToMany
exp-2 36
  • 29 (a)
OneToMany
kvs-1 36
  • 26 (a)
OneToMany
kvs-3 36
  • 31 (a)
OneToMany
kvs-4 36
  • 26 (a)
OneToMany
kvs-5 36
  • 21 (a)
OneToMany
C32C4.1 37
  • 33 (a)
F44A2.2 37
  • 32 (a)
exp-2 37
  • 38 (a)
Y48A6B.6 37
  • 33 (a)
Species with no ortholog for KCNF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNF1 Gene

ENSEMBL:
Gene Tree for KCNF1 (if available)
TreeFam:
Gene Tree for KCNF1 (if available)

Paralogs for KCNF1 Gene

Paralogs for KCNF1 Gene

Selected SIMAP similar genes for KCNF1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KCNF1 Gene

genes like me logo Genes that share paralogs with KCNF1: view

Variants for KCNF1 Gene

Sequence variations from dbSNP and Humsavar for KCNF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1046004 -- 10,913,493(+) TAAGA(A/G)CATCC missense, reference
rs1046005 -- 10,913,573(+) CGCTG(A/G)GCAAG missense, reference
rs1882651 -- 10,910,044(-) TGTGT(C/G)GAAAT upstream-variant-2KB
rs2602169 -- 10,914,056(+) CCTCT(C/G)CCAAG utr-variant-3-prime
rs2602170 -- 10,914,057(+) CTCTG(C/G)CAAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KCNF1 Gene

Variant ID Type Subtype PubMed ID
nsv873662 CNV Loss 21882294
nsv521177 CNV Loss 19592680

Relevant External Links for KCNF1 Gene

HapMap Linkage Disequilibrium report
KCNF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNF1 Gene

Disorders for KCNF1 Gene

No disorders were found for KCNF1 Gene.

No data available for UniProtKB/Swiss-Prot for KCNF1 Gene

Publications for KCNF1 Gene

  1. Isolation, characterization, and mapping of two human potassium channels. (PMID: 9434767) Su K. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  4. MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. (PMID: 23840749) Petko J. … Levenson R. (PLoS ONE 2013) 3
  5. Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. (PMID: 12445884) Godreau D. … Hatem S.N. (Cardiovasc. Res. 2002) 4

Products for KCNF1 Gene

Sources for KCNF1 Gene

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