Aliases for KCNE5 Gene
- Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5 2 3 5
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 5 2 3
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 1-Like 2 3
- Potassium Voltage-Gated Channel Subfamily E Member 1-Like Protein 3 4
- AMME Syndrome Candidate Gene 2 Protein 3 4
- Potassium Channel Subunit Beta MiRP4 3 4
- KCNE1L 3 4
External Ids for KCNE5 Gene
Previous HGNC Symbols for KCNE5 Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE5 Gene
KCNE5 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5) is a Protein Coding gene. Diseases associated with KCNE5 include Kcne5-Related Atrial Fibrillation and Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis. Among its related pathways are Cardiac conduction and Phase 1 - inactivation of fast Na+ channels. GO annotations related to this gene include ion channel binding and potassium channel regulator activity.
UniProtKB/Swiss-Prot for KCNE5 Gene
Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.