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KCNE4 Gene

protein-coding   GIFtS: 54
GCID: GC02P223880

Potassium Voltage-Gated Channel, Isk-Related Family, Member...

  Search for KCNE4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Potassium Voltage-Gated Channel, Isk-Related Family, Member 41 2     MIRP32 5
Minimum Potassium Ion Channel-Related Peptide 32 3     Cardiac Voltage-Gated Potassium Channel Accessory Subunit 42
MinK-Related Peptide 32 3     Potassium Voltage-Gated Channel Subfamily E Member 42
Potassium Channel Subunit Beta MiRP32 3     

External Ids:    HGNC: 62441   Entrez Gene: 237042   Ensembl: ENSG000001520497   OMIM: 6077755   UniProtKB: Q8WWG93   
ORGUL members:         

Export aliases for KCNE4 gene to outside databases

Previous GC identifers: GC02P221939 GC02P222637 GC02P224119 GC02P223742 GC02P223625 GC02P215768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KCNE4 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This
member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to
modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed
in the embryo and in adult uterus. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNE4 Gene:
KCNE4 (potassium voltage-gated channel, Isk-related family, member 4) is a protein-coding gene. GO annotations related to this gene include voltage-gated potassium channel activity.

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
associate with KCNQ1/KVLTQ1 and inhibit potassium current

summary for KCNE4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the KCNE4 gene promoter:
         E2F-3a   E2F-4   GR   Nkx3-1 v4   E2F-5   GR-beta   E2F-2   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNE4 promoter sequence
   Search Chromatin IP Primers for KCNE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KCNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

KCNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNE4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223880:  view genomic region     (about GC identifiers)

Start:
223,916,532 bp from pter      End:
224,063,117 bp from pter
Size:
146,586 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily E member 4  
Size: 170 amino acids; 18425 Da
Subunit: Associates with KCNQ1/KVLQT1 (Probable)
Secondary accessions: Q53SM4 Q96CC4

Explore the universe of human proteins at neXtProt for KCNE4: NX_Q8WWG9

Explore proteomics data for KCNE4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8

  • See KCNE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542402.3  
    ENSEMBL proteins: 
     ENSP00000281830   ENSP00000473755  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KCN: Potassium channels

    1 InterPro protein domain:
     IPR000369 K_chnl_volt-dep_bsu_KCNE

    Graphical View of Domain Structure for InterPro Entry Q8WWG9

    ProtoNet protein and cluster: Q8WWG9

    1 Blocks protein domain: IPB000369 KCNE voltage-gated K+ channel beta subunit family signature

    UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
    Similarity: Belongs to the potassium channel KCNE family


    Find genes that share domains with KCNE4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCNE4_HUMAN, Q8WWG9
    Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
    pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
    associate with KCNQ1/KVLTQ1 and inhibit potassium current

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005249voltage-gated potassium channel activity IEA--
         
    Find genes that share ontologies with KCNE4           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Kcne4 (no phenotypes)

    Find genes that share phenotypes with KCNE4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kcne4tm1Lex for KCNE4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KCNE4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNE4

    miRNA
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    Block miRNA regulation of human, mouse, rat KCNE4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KCNE4 (see all 29):
    hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidKCNE4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCNE4_HUMAN, Q8WWG9: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with KCNE4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KCNE4 About    
    See pathways by source

    SuperPathContained pathways About
    1Dopamine-DARPP32 Feedback onto cAMP Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    2Antiarrhythmic Pathway, Pharmacodynamics
    Antiarrhythmic Pathway, Pharmacodynamics

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KCNE4
        Dopamine-DARPP32 Feedback onto cAMP Pathway


    1 PharmGKB Pathway for KCNE4
        Antiarrhythmic Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KCNE4
    Interactions:

        GeneGlobe Interaction Network for KCNE4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KCNE4 (Q8WWG93 ENSP000002818304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNQ1P517873, ENSP000001558404I2D: score=1 STRING: ENSP00000155840
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    KCNA1Q094703I2D: score=1 
    --ENSP000002288584STRING: ENSP00000228858
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----

    Find genes that share ontologies with KCNE4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KCNE4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
    XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
    JNJ 303Potent and selective IKs blocker[878489-28-2]
    E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
    ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KCNE4 gene: 
    NM_080671.3  

    Unigene Cluster for KCNE4:

    Potassium voltage-gated channel, Isk-related family, member 4
    Hs.348522  [show with all ESTs]
    Unigene Representative Sequence: NM_080671
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281830(uc002vnl.4) ENST00000488477 ENST00000604125
    miRNA
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    hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
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    OriGene qPCR primer pairs and template standards for KCNE4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KCNE4
      QuantiTect SYBR Green Assays in human, mouse, rat KCNE4
      QuantiFast Probe-based Assays in human, mouse, rat KCNE4

    Additional mRNA sequence: 

    AK294423.1 AK313203.1 AY065987.1 BC014429.1 DQ192293.1 

    3 DOTS entries:

    DT.97840581  DT.100834171  DT.97806316 

    Selected AceView cDNA sequences (see all 50):

    AA730156 AA058640 AI287239 BM820427 BQ421396 CK818864 CN481584 BQ436497 
    BX499846 BX327956 BG330322 BX381340 AA479033 BI756417 AI002715 NM_080671 
    BQ718246 BQ216886 BU158875 BM126272 AI375138 BM662449 AY065987 BP362695 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KCNE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTGTCA
    KCNE4 Expression
    About this image


    KCNE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
    KCNE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KCNE4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348522

    UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
    Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small
    intestine, lung and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KCNE4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kcne41 , 5 potassium voltage-gated channel, Isk-related subfamily, more1, 5 86.67(n)1
    90(a)1
      1 (40.89 cM)5
    578141  NM_021342.11  NP_067317.11 
     788169495 
    chicken
    (Gallus gallus)
    Aves KCNE41 potassium voltage-gated channel, Isk-related family, more 72.6(n)
    73.01(a)
      771271  XM_004937040.1  XP_004937097.1 
    lizard
    (Anolis carolinensis)
    Reptilia KCNE46
    potassium voltage-gated channel, Isk-related famil...
    60(a)
    1 ↔ 1
    3(25348530-25353166)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kcne41 potassium voltage-gated channel, Isk-related family, more 55.63(n)
    52.32(a)
      100490086  XM_002936603.2  XP_002936649.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kcne41 potassium voltage-gated channel, Isk-related family, more 56.62(n)
    50.68(a)
      794240  NM_001082897.1  NP_001076366.1 


    ENSEMBL Gene Tree for KCNE4 (if available)
    TreeFam Gene Tree for KCNE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KCNE4 gene
    1 SIMAP similar gene for KCNE4 using alignment to 3 protein entries:     KCNE4_HUMAN (see all proteins):
    KCNE1

    Find genes that share paralogs with KCNE4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KCNE4 (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811418741,2
    --223914717(+) AATTTC/TTGTAT 1 -- us2k10--------
    rs1162167561,2
    C,F--223914802(+) CTCAGC/ACTCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1866617521,2
    --223914827(+) ACTGAA/GCTAAG 1 -- us2k10--------
    rs348607911,2
    C,F--223914828(+) CTGAAC/ATAAGA 1 -- us2k15Minor allele frequency- A:0.05NA CSA WA 244
    rs118904211,2
    C,F,A,H--223914850(+) GCCTCG/TTTTAA 1 -- us2k134Minor allele frequency- N:0.00NS EA NA WA CSA 3399
    rs725487891,2
    C,F--223914975(+) CTGCTT/CTTCCT 1 -- us2k13Minor allele frequency- C:0.00CSA WA 856
    rs343484021,2
    C,F--223914998(+) TGCTTC/TGTCCT 1 -- us2k17Minor allele frequency- T:0.01NA CSA WA 982
    rs1468037061,2
    --223915106(+) AACTTC/TAGCCT 1 -- us2k10--------
    rs413110391,2
    C,F--223915240(+) TGACCA/GATCTC 1 -- us2k14Minor allele frequency- G:0.05NS NA EA 560
    rs1421459861,2
    C--223915351(+) AGGCT-/TAGA  
            
    TATAG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KCNE4 (223916532 - 224063117 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KCNE4: --
    Human Gene Mutation Database (HGMD): KCNE4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KCNE4
    DNA2.0 Custom Variant and Variant Library Synthesis for KCNE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607775    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for KCNE4:
    Long QT syndrome

    Find genes that share disorders with KCNE4           About GenesLikeMe

    Genetic Association Database (GAD): KCNE4
    Human Genome Epidemiology (HuGE) Navigator: KCNE4 (2 documents)

    Export disorders for KCNE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KCNE4 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with KCNE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (Obesity (Silver Spring) 2011)
    2. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    3. The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population. (PubMed id 17016049)1, 4 Zeng Z....Pu J. (Cardiology 2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. [The association of single nucleotide polymorphism of slow delayed rectifier K+ channel genes with atrial fibrillation in Han nationality Chinese]. (PubMed id 16563243)1, 4 Zeng Z.Y....Gu D.F. (Zhonghua Xin Xue Guan Bing Za Zhi 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Novel gene hKCNE4 slows the activation of the KCNQ1 channel. (PubMed id 12670483)1, 3 Teng S....Hui R. (Biochem. Biophys. Res. Commun. 2003)
    8. KCNE4 is an inhibitory subunit to the KCNQ1 channel. (PubMed id 12096056)1, 2 Grunnet M.... Klaerke D.A. (J. Physiol. (Lond.) 2002)
    9. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PubMed id 10219239)1, 3 Abbott G.W.... Goldstein S.A.N. (Cell 1999)
    10. KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. (PubMed id 19773357)1, 9 SolAc L....Felipe A. (J. Cell. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23704 HGNC: 6244 AceView: KCNE4 Ensembl:ENSG00000152049 euGenes: HUgn23704
    ECgene: KCNE4 H-InvDB: KCNE4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KCNE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KCNE4 gene:
    Search GeneIP for patents involving KCNE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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