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Aliases & Descriptions for KCNE4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC20353 2 | | MIRP3 2, 5 | | MiRP3 1 |
| | | Descriptions |
|---|
| MinK-related peptide 3 2, 3 | | Minimum potassium ion channel-related peptide 3 2, 3 | | Potassium channel subunit beta MiRP3 3 | | cardiac voltage-gated potassium channel accessory subunit 4 2 | | potassium voltage-gated channel subfamily E member 4 2 | potassium voltage-gated channel, Isk-related family, member 4 2 |
|
| | Search outside databases for aliases for KCNE4 genePrevious GC identifers: GC02P221939 GC02P222637 GC02P223880 GC02P224119 GC02P223742 |
Summaries for KCNE4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KCNE4: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq] UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium currentGene Wiki entry for KCNE4 |
Genomic Location for KCNE4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KCNE4 gene 
Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.1 HGNC cytogenetic band: 2q36.1KCNE4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P223625:
(about GC identifiers)
Start:
|
223,625,106 bp from pter |
End:
|
223,628,599 bp from pter |
Size:
|
3,494 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for KCNE4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9 (See
protein sequence)Recommended Name: Potassium voltage-gated channel subfamily E member 4 Size: 170 amino acids; 18439 Da
Subunit: Associates with KCNQ1/KVLQT1 (Probable)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q53SM4 Q96CC4REFSEQ proteins: NP_542402.2
ENSEMBL proteins: ENSP00000281830
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KCNE4: Assays for KCNE4: | Protein
Domains/ Families for KCNE4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8WWG9
ProtoNet protein and cluster: Q8WWG9 1 Blocks protein family: IPB000369 KCNE voltage-gated K+ channel beta subunit family signature
UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9Similarity: Belongs to the potassium channel KCNE family | Gene Function for KCNE4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080671
Applied Biosystems Silencer® siRNAs for KCNE4
Sigma-Aldrich siRNA for KCNE4  Sigma-Aldrich shRNA for KCNE4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080671                                  untagged cDNA clone in CMV expression vector: NM_080671 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080671
UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current1 MGI phenotypic allele for Kcne4 (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005244 | voltage-gated ion channel activity |
IEA | -- | | GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0030955 | potassium ion binding |
IEA | -- | About this table | Pathways & Interactions for KCNE4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for KCNE4 
5 Interacting proteins for KCNE4 (ENSP000002818303) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
IEA | -- | About this table
|
Drugs & Compounds for KCNE4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNE4 available from Tocris Bioscience About this table
1 PharmGKB drug compound relationship for KCNE4 gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| antiarrhythmics | FA   | 12096056 | About this table
|
Transcripts for KCNE4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080671
Sigma-Aldrich siRNA for KCNE4  Sigma-Aldrich shRNA for KCNE4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080671 REFSEQ mRNAs for KCNE4 gene: NM_080671.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080671               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080671                                  untagged cDNA clone in CMV expression vector: NM_080671  Additional cDNA sequence: AK294423.1 AK313203.1 AY065987.1 BC014429.1 DQ192293.1 3 DOTS entries: DT.97840581 DT.100834171 DT.97806316 24/50 AceView cDNA sequences (see all 50
):AI287239 BM820427 AA730156 AA058640 CK818864 BX324837 BX381340 BQ216886 BP348485 BX327955 BM126272 BC014429 AA479033 CA390179 BQ421396 BQ718246 BF793600 AY065987 BX499846 AI375138 CN481584 BI756417 BX327956 AI002715
highest scoring ESTs for KCNE4:AA730156 AI375138 AW748651 AY065987 BC014429 BF793600 BG330322 BQ215885 BQ216886 BQ420572 Unigene Cluster for KCNE4: Potassium voltage-gated channel, Isk-related family, member 4 Hs.348522 [show with all ESTs]Unigene Representative Sequence: NM_080671
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000281830
|
Expression for KCNE4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KCNE4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KCNE4
1 / 2 / 3 5 probe-sets matching KCNE4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCCTTGTCA
SOURCE GeneReport for Unigene cluster: Hs.348522 UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart |
Orthologs for KCNE4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNE4 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
KCNE41 |
-- |
potassium voltage-gated channel, Isk-related family, more |
91.76(n) 91.76(a) |
488549 XM_545668.2 XP_545668.1 |
chimpanzee (Pan troglodytes) |
LOC7444781 |
-- |
hypothetical protein LOC744478 |
99.22(n) 99.41(a) |
744478 XM_001166586.1 XP_001166586.1 |
cow (Bos taurus) |
KCNE41 |
-- |
potassium voltage-gated channel, Isk-related family, more |
88.1(n) 88.69(a) |
615761 XM_879929.2 XP_885022.1 |
rat (Rattus norvegicus) |
Kcne41 |
-- |
potassium voltage-gated channel, Isk-related subfamily, more |
87.25(n) 90.59(a) |
367302 NM_212526.1 NP_997691.1 |
mouse (Mus musculus) |
Kcne41, 5 |
15
|
potassium voltage-gated channel, Isk-related subfamily, more1, 5 |
86.67(n)1 90(a)1 |
578141 NM_021342.11 NP_067317.11 AF0765335 AK1334695 (see all 10) |
About this table Species with no ortholog for KCNE4
ENSEMBL Gene Tree for KCNE4 | Paralogs for KCNE4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for KCNE4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KCNE4 (up to first 250kb)
|
Disorders & Mutations for KCNE4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607775
Human Gene Mutation Database: KCNE4 Human Genome Epidemiology Navigator: KCNE4 (2 documents)
|
Medical News for KCNE4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KCNE4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for KCNE4 gene (see all 20
): |
Search for KCNE4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KCNE4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KCNE4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNE4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KCNE4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KCNE4:

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| | | | Tocris compounds for KCNE4 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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