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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNE4 Gene

protein-coding   GIFtS: 50
GCID: GC02P223880

potassium voltage-gated channel, Isk-related family, member...

 Explore 6 diseases affiliated with
KCNE4 via our new
 Human Malady Compendium 
Biological research products
for KCNE4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Isk-Related Family, Member 41 2     MIRP32 5
Minimum Potassium Ion Channel-Related Peptide 32 3     MiRP31
MinK-Related Peptide 32 3     Cardiac Voltage-Gated Potassium Channel Accessory Subunit 42
Potassium Channel Subunit Beta MiRP32 3     Potassium Voltage-Gated Channel Subfamily E Member 42

External Ids:    HGNC: 62441   Entrez Gene: 237042   Ensembl: ENSG000001520497   OMIM: 6077755   UniProtKB: Q8WWG93   

Export aliases for KCNE4 gene to outside databases

Previous GC identifers: GC02P221939 GC02P222637 GC02P224119 GC02P223742 GC02P223625 GC02P215768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNE4:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a
type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the
gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and
in adult uterus. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
associate with KCNQ1/KVLTQ1 and inhibit potassium current

summary for KCNE4:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNE4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNE4 gene promoter:
         E2F-3a   E2F-4   GR   Nkx3-1 v4   E2F-5   GR-beta   E2F-2   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNE4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

KCNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNE4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223880:  view genomic region     (about GC identifiers)

Start:
223,916,532 bp from pter      End:
224,063,117 bp from pter
Size:
146,586 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily E member 4  
Size: 170 amino acids; 18425 Da
Subunit: Associates with KCNQ1/KVLQT1 (Probable)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q53SM4 Q96CC4

Explore the universe of human proteins at neXtProt for KCNE4: NX_Q8WWG9

KCNE4 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_542402.3  
ENSEMBL proteins: 
 ENSP00000281830  

Human Recombinant Protein Products: 
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OriGene Protein Over-expression Lysate: KCNE4
OriGene Custom Protein Services for KCNE4 
GenScript Custom Purified and Recombinant Proteins Services for KCNE4
Novus Biologicals KCNE4 Protein
Novus Biologicals KCNE4 Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for KCNE4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--
GO:0016324apical plasma membrane IEA--


KCNE4 for ontologies           About GeneDecksing



KCNE4 Antibody Products: 
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Uscn Antibodies for KCNE4
Search ThermoFisher Antibodies for KCNE4

Assay Products for KCNE4: 
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Uscn ELISAs and CLIAs for KCNE4


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNE4 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR000369 K_chnl_volt-dep_bsu_KCNE

Graphical View of Domain Structure for InterPro Entry Q8WWG9

ProtoNet protein and cluster: Q8WWG9

1 Blocks protein family: IPB000369 KCNE voltage-gated K+ channel beta subunit family signature

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Similarity: Belongs to the potassium channel KCNE family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
associate with KCNQ1/KVLTQ1 and inhibit potassium current

miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNE4
8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNE4 (see all 29):
hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidKCNE4 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNE4 (see all 7)
OriGene shRNA RFP: KCNE4
OriGene siRNA: KCNE4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNE4

Gene Editing
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Clone
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNE4 

Cell Line
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Search LifeMap BioReagents cell lines for KCNE4

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNE4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005249voltage-gated potassium channel activity IEA--


KCNE4 for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Kcne4tm1Lex for KCNE4
     1 MGI phenotypic allele for Kcne4 (no phenotypes)

KCNE4 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Dopamine-DARPP32 Feedback onto cAMP Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway1.00
2Antiarrhythmic Pathway, Pharmacodynamics
Antiarrhythmic Pathway, Pharmacodynamics1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNE4
    Dopamine-DARPP32 Feedback onto cAMP Pathway

1 PharmGKB Pathway for KCNE4
    Antiarrhythmic Pathway, Pharmacodynamics

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNE4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for KCNE4 (Q8WWG93 ENSP000002818304) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KCNQ1P517873, ENSP000001558404I2D: score=1 STRING: ENSP00000155840
PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
KCNA1Q094703I2D: score=1 
--ENSP000002288584STRING: ENSP00000228858
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNE4 available from Tocris Bioscience    About this table
CompoundAction CAS #
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
4-AminopyridineNon-selective KV channel blocker[504-24-5]
Search CenterWatch for drugs/clinical trials and news about KCNE4 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNE4 gene: 
NM_080671.3  

Unigene Cluster for KCNE4:

Potassium voltage-gated channel, Isk-related family, member 4
Hs.348522  [show with all ESTs]
Unigene Representative Sequence: NM_080671
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000281830(uc002vnl.4) ENST00000488477

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNE4
8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNE4 (see all 29):
hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidKCNE4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KCNE4 (see all 7)
OriGene shRNA RFP: KCNE4
OriGene siRNA: KCNE4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNE4
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KCNE4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KCNE4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: KCNE4 (NM_080671)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNE4 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNE4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNE4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNE4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNE4

Additional cDNA sequence: 

AK294423.1 AK313203.1 AY065987.1 BC014429.1 DQ192293.1 

3 DOTS entries:

DT.97840581  DT.100834171  DT.97806316 

24/50 AceView cDNA sequences (see all 50):

AA730156 AI287239 AA058640 BM820427 CA390179 BQ421396 BX327956 AY065987 
BG330322 CK818864 BX327955 BX381340 AI375138 BQ215885 BQ718246 BM126272 
BP374050 BP362695 AI620414 BI756417 BP359441 AA479033 BX324837 BM907429 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNE4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTTGTCA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See KCNE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNE4

SOURCE GeneReport for Unigene cluster: Hs.348522

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small
intestine, lung and heart

    SABiosciences Custom PCR Arrays for KCNE4
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KCNE4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNE4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNE4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNE4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNE4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCNE4 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcne41 , 5 potassium voltage-gated channel, Isk-related subfamily, more1, 5 86.67(n)1
90(a)1
  1 (40.89 cM)5
578141  NM_021342.11  NP_067317.11 
 788169495 
chicken
(Gallus gallus)
Aves KCNE41 potassium voltage-gated channel, Isk-related family, more 74.44(n)
76(a)
  771271  XM_003641755.1  XP_003641803.1 
lizard
(Anolis carolinensis)
Reptilia KCNE46
--
69(a)
1 ↔ 1
3(25350539-25351057)
zebrafish
(Danio rerio)
Actinopterygii kcne41 potassium voltage-gated channel, Isk-related family, more 56.85(n)
50(a)
  794240  NM_001082897.1  NP_001076366.1 


ENSEMBL Gene Tree for KCNE4 (if available)
TreeFam Gene Tree for KCNE4 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 NCBI SNPs in KCNE4 are shown (see all 128    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs346453301,2
C,--215768779(+) TTTTT-/AATCAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
rs726171261,2
C,--215768779(+) TTTTTA/TATCAA 1 -- int10--------
rs1811418741,2
--223914717(+) AATTTC/TTGTAT 1 -- us2k10--------
rs1162167561,2
F,--223914802(+) CTCAGC/ACTCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1866617521,2
--223914827(+) ACTGAA/GCTAAG 1 -- us2k10--------
rs348607911,2
C,F,--223914828(+) CTGAAC/ATAAGA 1 -- us2k15Minor allele frequency- A:0.05NA CSA WA 244
rs118904211,2
C,F,A,H,--223914850(+) GCCTCG/TTTTAA 1 -- us2k134Minor allele frequency- N:0.00NS EA NA WA CSA 3399
rs725487891,2
C,--223914975(+) CTGCTT/CTTCCT 1 -- us2k13Minor allele frequency- C:0.00CSA WA 856
rs343484021,2
C,F,--223914998(+) TGCTTC/TGTCCT 1 -- us2k17Minor allele frequency- T:0.01NA CSA WA 982
rs1468037061,2
--223915106(+) AACTTC/TAGCCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for KCNE4 (223916532 - 224063117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KCNE4: --
Human Gene Mutation Database (HGMD): KCNE4

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KCNE4
DNA2.0 Custom Variant and Variant Library Synthesis for KCNE4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNE4 for disorders           About GeneDecksing

OMIM gene information: 607775    OMIM disorders: --

6 diseases for KCNE4:    About MalaCards
atrial fibrillation    familial atrial fibrillation    quadriplegia    lymphoblastic leukemia
neuronitis    leukemia

1 disease from the University of Copenhagen DISEASES database for KCNE4:
Long QT syndrome
Human Genome Epidemiology (HuGE) Navigator: KCNE4 (2 documents)

Export disorders for KCNE4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KCNE4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with KCNE4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Novel gene hKCNE4 slows the activation of the KCNQ1 channel. (PubMed id 12670483)1, 3 Teng S....Hui R. (2003)
  4. KCNE4 is an inhibitory subunit to the KCNQ1 channel. (PubMed id 12096056)1, 2 Grunnet M.... Klaerke D.A. (2002)
  5. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PubMed id 10219239)1, 3 Abbott G.W.... Goldstein S.A.N. (1999)
  6. KCNE4 suppresses Kv1.3 currents by modulating traffic king, surface expression and channel gating. (PubMed id 19773357)1, 9 SolAc L....Felipe A. (2009)
  7. KCNE4 juxtamembrane region is required for interactio n with calmodulin and for functional suppression of KCNQ1. (PubMed id 21118809)1 Ciampa E.J....George A.L. (2011)
  8. The membrane protein MiRP3 regulates Kv4.2 channels i n a KChIP-dependent manner. (PubMed id 20498229)1 Levy D.I....Goldstein S.A. (2010)
  9. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
  10. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1 TreviA+o L.R....Relling M.V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 23704 HGNC: 6244 AceView: KCNE4 Ensembl:ENSG00000152049 euGenes: HUgn23704
ECgene: KCNE4 H-InvDB: KCNE4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KCNE4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KCNE4 gene:
Search GeneIP for patents involving KCNE4

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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von Willebrand factor
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