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Aliases for KCNE4 Gene

Aliases for KCNE4 Gene

  • Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4 2 3
  • Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 4 2 3 5
  • Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 2 3
  • Minimum Potassium Ion Channel-Related Peptide 3 3 4
  • Potassium Channel Subunit Beta MiRP3 3 4
  • Cardiac Voltage-Gated Potassium Channel Accessory Subunit 4 3
  • MINK-Related Peptide 3 3
  • MinK-Related Peptide 3 4
  • MIRP3 3

External Ids for KCNE4 Gene

Previous GeneCards Identifiers for KCNE4 Gene

  • GC02P221939
  • GC02P222637
  • GC02P223880
  • GC02P224119
  • GC02P223742
  • GC02P223625
  • GC02P215768

Summaries for KCNE4 Gene

Entrez Gene Summary for KCNE4 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNE4 Gene

KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4) is a Protein Coding gene. Diseases associated with KCNE4 include hypokalemic periodic paralysis, type 1. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include voltage-gated potassium channel activity.

UniProtKB/Swiss-Prot for KCNE4 Gene

  • Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.

Tocris Summary for KCNE4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNE4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNE4 Gene

Genomics for KCNE4 Gene

Regulatory Elements for KCNE4 Gene

Enhancers for KCNE4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KCNE4 on UCSC Golden Path with GeneCards custom track

Promoters for KCNE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNE4 Gene

Chromosome:
2
Start:
223,051,814 bp from pter
End:
223,198,399 bp from pter
Size:
146,586 bases
Orientation:
Plus strand

Genomic View for KCNE4 Gene

Genes around KCNE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNE4 Gene

Proteins for KCNE4 Gene

  • Protein details for KCNE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWG9-KCNE4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily E member 4
    Protein Accession:
    Q8WWG9
    Secondary Accessions:
    • B7Z275
    • Q53SM4
    • Q96CC4

    Protein attributes for KCNE4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23806 Da
    Quaternary structure:
    • Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.
    SequenceCaution:
    • Sequence=AAH14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL49979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KCNE4 Gene

Proteomics data for KCNE4 Gene at MOPED

Post-translational modifications for KCNE4 Gene

  • Glycosylation at Asn 9
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNE4 Gene

Domains & Families for KCNE4 Gene

Protein Domains for KCNE4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWG9

UniProtKB/Swiss-Prot:

KCNE4_HUMAN :
  • Belongs to the potassium channel KCNE family.
Family:
  • Belongs to the potassium channel KCNE family.
genes like me logo Genes that share domains with KCNE4: view

Function for KCNE4 Gene

Molecular function for KCNE4 Gene

UniProtKB/Swiss-Prot Function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.
genes like me logo Genes that share phenotypes with KCNE4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNE4 Gene

Localization for KCNE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNE4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNE4 Gene COMPARTMENTS Subcellular localization image for KCNE4 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with KCNE4: view

Pathways & Interactions for KCNE4 Gene

genes like me logo Genes that share pathways with KCNE4: view

Pathways by source for KCNE4 Gene

Gene Ontology (GO) - Biological Process for KCNE4 Gene

None

No data available for SIGNOR curated interactions for KCNE4 Gene

Drugs & Compounds for KCNE4 Gene

(1) Drugs for KCNE4 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flupirtine maleate Pharma KV7 channel activator 0

(4) Additional Compounds for KCNE4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNE4 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNE4: view

Transcripts for KCNE4 Gene

mRNA/cDNA for KCNE4 Gene

Unigene Clusters for KCNE4 Gene

Potassium voltage-gated channel, Isk-related family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNE4 Gene

No ASD Table

Relevant External Links for KCNE4 Gene

GeneLoc Exon Structure for
KCNE4
ECgene alternative splicing isoforms for
KCNE4

Expression for KCNE4 Gene

mRNA expression in normal human tissues for KCNE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNE4 Gene

This gene is overexpressed in Artery - Tibial (x4.4).

SOURCE GeneReport for Unigene cluster for KCNE4 Gene Hs.348522

mRNA Expression by UniProt/SwissProt for KCNE4 Gene

Q8WWG9-KCNE4_HUMAN
Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.
genes like me logo Genes that share expression patterns with KCNE4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KCNE4 Gene

Orthologs for KCNE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNE4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNE4 35
  • 88.1 (n)
  • 88.69 (a)
KCNE4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNE4 35
  • 87.18 (n)
  • 83.71 (a)
KCNE4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcne4 35
  • 86.67 (n)
  • 90 (a)
Kcne4 16
Kcne4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNE4 35
  • 99.1 (n)
  • 98.64 (a)
KCNE4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcne4 35
  • 87.25 (n)
  • 90.59 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNE4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNE4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNE4 35
  • 72.6 (n)
  • 73.01 (a)
KCNE4 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNE4 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcne4 35
  • 55.63 (n)
  • 52.32 (a)
zebrafish
(Danio rerio)
Actinopterygii kcne4 35
  • 56.62 (n)
  • 50.68 (a)
kcne4 36
  • 43 (a)
OneToOne
Species with no ortholog for KCNE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNE4 Gene

ENSEMBL:
Gene Tree for KCNE4 (if available)
TreeFam:
Gene Tree for KCNE4 (if available)

Paralogs for KCNE4 Gene

(1) SIMAP similar genes for KCNE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNE4: view

No data available for Paralogs for KCNE4 Gene

Variants for KCNE4 Gene

Sequence variations from dbSNP and Humsavar for KCNE4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12621643 - 223,053,265(+) GACGA(G/T)GAGCT reference, missense
rs13409084 - 223,052,969(+) TCTAC(A/G)GCATT reference, missense
rs3795884 -- 223,053,645(-) GGCAA(A/G)CATAT utr-variant-3-prime
rs3795885 -- 223,053,615(-) CAGAA(C/T)CCCAA utr-variant-3-prime
rs3795886 -- 223,052,911(-) CCGCC(A/G)CCGGC reference, synonymous-codon

Variation tolerance for KCNE4 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNE4 Gene

HapMap Linkage Disequilibrium report
KCNE4
Human Gene Mutation Database (HGMD)
KCNE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNE4 Gene

Disorders for KCNE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNE4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypokalemic periodic paralysis, type 1
  • familial periodic paralysis
- elite association - COSMIC cancer census association via MalaCards
Search KCNE4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNE4

Genetic Association Database (GAD)
KCNE4
Human Genome Epidemiology (HuGE) Navigator
KCNE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNE4
genes like me logo Genes that share disorders with KCNE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNE4 Gene

Publications for KCNE4 Gene

  1. Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. (PMID: 19687231) Vanoye C.G. … George A.L. (J. Gen. Physiol. 2009) 3 4 23 67
  2. KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. (PMID: 19773357) SolAc L. … Felipe A. (J. Cell. Sci. 2009) 3 23
  3. Novel gene hKCNE4 slows the activation of the KCNQ1 channel. (PMID: 12670483) Teng S. … Hui R. (Biochem. Biophys. Res. Commun. 2003) 2 3
  4. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PMID: 10219239) Abbott G.W. … Goldstein S.A.N. (Cell 1999) 2 3
  5. [Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant]. (PMID: 23866632) FreA-din M.B. … Puzyrev V.P. (Genetika 2013) 3

Products for KCNE4 Gene

Sources for KCNE4 Gene

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