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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KCNE4 Gene

protein-coding   GIFtS: 53
GCID: GC02P223880

Potassium Voltage-Gated Channel, Isk-Related Family, Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Potassium Voltage-Gated Channel, Isk-Related Family, Member 41 2     MIRP32 5
Minimum Potassium Ion Channel-Related Peptide 32 3     Cardiac Voltage-Gated Potassium Channel Accessory Subunit 42
MinK-Related Peptide 32 3     Potassium Voltage-Gated Channel Subfamily E Member 42
Potassium Channel Subunit Beta MiRP32 3     

External Ids:    HGNC: 62441   Entrez Gene: 237042   Ensembl: ENSG000001520497   OMIM: 6077755   UniProtKB: Q8WWG93   

Export aliases for KCNE4 gene to outside databases

Previous GC identifers: GC02P221939 GC02P222637 GC02P224119 GC02P223742 GC02P223625 GC02P215768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNE4 Gene:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and
cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This
member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to
modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed
in the embryo and in adult uterus. (provided by RefSeq, Jul 2008)

GeneCards Summary for KCNE4 Gene: 
KCNE4 (potassium voltage-gated channel, Isk-related family, member 4) is a protein-coding gene. Diseases associated with KCNE4 include familial atrial fibrillation, and quadriplegia. GO annotations related to this gene include voltage-gated potassium channel activity.

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
associate with KCNQ1/KVLTQ1 and inhibit potassium current

summary for KCNE4 Gene:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNE4 gene promoter:
         E2F-3a   E2F-4   GR   Nkx3-1 v4   E2F-5   GR-beta   E2F-2   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKCNE4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KCNE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KCNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.1

KCNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNE4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223880:  view genomic region     (about GC identifiers)

Start:
223,916,532 bp from pter      End:
224,063,117 bp from pter
Size:
146,586 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily E member 4  
Size: 170 amino acids; 18425 Da
Subunit: Associates with KCNQ1/KVLQT1 (Probable)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q53SM4 Q96CC4

Explore the universe of human proteins at neXtProt for KCNE4: NX_Q8WWG9

Explore proteomics data for KCNE4 at MOPED 

KCNE4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KCNE4 Protein Expression

REFSEQ proteins: NP_542402.3  
ENSEMBL proteins: 
 ENSP00000281830   ENSP00000473755  

Human Recombinant Protein Products for KCNE4: 
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OriGene Protein Over-expression Lysate for KCNE4
OriGene Custom MassSpec 
OriGene Custom Protein Services for KCNE4
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Novus Biologicals KCNE4 Protein
Novus Biologicals KCNE4 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for KCNE4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral to membrane IEA--
GO:0016324apical plasma membrane ----

KCNE4 for ontologies           About GeneDecksing



KCNE4 Antibody Products: 
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Abcam antibodies for KCNE4
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LSBio Antibodies in human, mouse, rat for KCNE4 

Assay Products for KCNE4: 
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GenScript Custom Assay Services for KCNE4
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Cloud-Clone Corp. ELISAs for KCNE4 
Cloud-Clone Corp. CLIAs for KCNE4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KCN: Potassium channels

1 InterPro protein domain:
 IPR000369 K_chnl_volt-dep_bsu_KCNE

Graphical View of Domain Structure for InterPro Entry Q8WWG9

ProtoNet protein and cluster: Q8WWG9

1 Blocks protein domain: IPB000369 KCNE voltage-gated K+ channel beta subunit family signature

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Similarity: Belongs to the potassium channel KCNE family


KCNE4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KCNE4_HUMAN, Q8WWG9
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of
pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May
associate with KCNQ1/KVLTQ1 and inhibit potassium current

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005249voltage-gated potassium channel activity IEA--
     
KCNE4 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Kcne4 (no phenotypes)

KCNE4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Kcne4tm1Lex for KCNE4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for KCNE4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KCNE4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KCNE4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KCNE4 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNE4
8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNE4 (see all 29):
hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidKCNE4 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of KCNE4

Clone
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OriGene clones in human, mouse for KCNE4 (see all 6)
OriGene ORF clones in mouse, rat for KCNE4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KCNE4 (NM_080671)
Sino Biological Human cDNA Clone for KCNE4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNE4
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                     Customized lentivirus expression plasmids for stable overexpression of KCNE4 

Cell Line
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Search LifeMap BioReagents cell lines for KCNE4
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNE4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for KCNE4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Dopamine-DARPP32 Feedback onto cAMP Pathway
Dopamine-DARPP32 Feedback onto cAMP Pathway
2Antiarrhythmic Pathway, Pharmacodynamics
Antiarrhythmic Pathway, Pharmacodynamics

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KCNE4
    Dopamine-DARPP32 Feedback onto cAMP Pathway


1 PharmGKB Pathway for KCNE4
    Antiarrhythmic Pathway, Pharmacodynamics

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNE4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for KCNE4 (Q8WWG93 ENSP000002818304) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KCNQ1P517873, ENSP000001558404I2D: score=1 STRING: ENSP00000155840
PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
KCNA1Q094703I2D: score=1 
--ENSP000002288584STRING: ENSP00000228858
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----

KCNE4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNE4 available from Tocris Bioscience    About this table
CompoundAction CAS #
ICA 110381KV7.2/7.3 activator; displays anticonvulsant properties[325457-99-6]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
JNJ 303Potent and selective IKs blocker[878489-28-2]
E-4031 dihydrochlorideKV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)[113559-13-0]
ShK-Dap22Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro[220384-25-8]

Search CenterWatch for drugs/clinical trials and news about KCNE4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KCNE4 gene: 
NM_080671.3  

Unigene Cluster for KCNE4:

Potassium voltage-gated channel, Isk-related family, member 4
Hs.348522  [show with all ESTs]
Unigene Representative Sequence: NM_080671
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000281830(uc002vnl.4) ENST00000488477 ENST00000604125
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KCNE4
8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KCNE4 (see all 29):
hsa-miR-300 hsa-miR-15a hsa-miR-767-5p hsa-miR-331-3p hsa-miR-766 hsa-miR-1297 hsa-miR-424 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidKCNE4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for KCNE4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KCNE4
Clone
Products:
     
OriGene clones in human, mouse for KCNE4 (see all 6)
OriGene ORF clones in mouse, rat for KCNE4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KCNE4 (NM_080671)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KCNE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KCNE4
Sirion Biotech Customized lentivirus for stable overexpression of KCNE4 
                     Customized lentivirus expression plasmids for stable overexpression of KCNE4 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for KCNE4
OriGene qSTAR qPCR primer pairs in human, mouse for KCNE4
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KCNE4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNE4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNE4

Additional mRNA sequence: 

AK294423.1 AK313203.1 AY065987.1 BC014429.1 DQ192293.1 

3 DOTS entries:

DT.97840581  DT.100834171  DT.97806316 

24/50 AceView cDNA sequences (see all 50):

AA058640 BM820427 AA730156 AI287239 BX324837 BX499846 BQ421396 BU153359 
BC014429 BI756417 BF793600 CK818864 BQ436497 AI375138 BM126272 BM662449 
AI620414 AA479033 BP359441 CB117750 BP362679 NM_080671 BP362695 BP348485 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KCNE4 expression in normal human tissues (normalized intensities)      KCNE4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCCTTGTCA
KCNE4 Expression
About this image


KCNE4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Uterus (Reproductive System)    fully expand to see all 2 entries
         myometrium   
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Heart (Cardiovascular System)
         Atrioventricular Node Cells Atrioventricular Node
 
 Endothelium (Cardiovascular System)
         aorta   
 
 Eye (Sensory Organs)
         optic nerve head astrocytes   

See KCNE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KCNE4

SOURCE GeneReport for Unigene cluster: Hs.348522

UniProtKB/Swiss-Prot: KCNE4_HUMAN, Q8WWG9
Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small
intestine, lung and heart

    SABiosciences Custom PCR Arrays for KCNE4
Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KCNE4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KCNE4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KCNE4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KCNE4 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Kcne41 , 5 potassium voltage-gated channel, Isk-related subfamily, more1, 5 86.67(n)1
90(a)1
  1 (40.89 cM)5
578141  NM_021342.11  NP_067317.11 
 788169495 
chicken
(Gallus gallus)
Aves KCNE41 potassium voltage-gated channel, Isk-related family, more 74.44(n)
76(a)
  771271  XM_003641755.1  XP_003641803.1 
lizard
(Anolis carolinensis)
Reptilia KCNE46
Uncharacterized protein
60(a)
1 ↔ 1
3(25348530-25353166)
zebrafish
(Danio rerio)
Actinopterygii kcne41 potassium voltage-gated channel, Isk-related family, more 56.85(n)
50(a)
  794240  NM_001082897.1  NP_001076366.1 


ENSEMBL Gene Tree for KCNE4 (if available)
TreeFam Gene Tree for KCNE4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KCNE4 gene
1 SIMAP similar gene for KCNE4 using alignment to 3 protein entries:     KCNE4_HUMAN (see all proteins):
KCNE1

KCNE4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/146 SNPs in KCNE4 are shown (see all 146)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811418741,2
--223914717(+) AATTTC/TTGTAT 1 -- us2k10--------
rs1162167561,2
C,F--223914802(+) CTCAGC/ACTCTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1866617521,2
--223914827(+) ACTGAA/GCTAAG 1 -- us2k10--------
rs348607911,2
C,F--223914828(+) CTGAAC/ATAAGA 1 -- us2k15Minor allele frequency- A:0.05NA CSA WA 244
rs118904211,2
C,F,A,H--223914850(+) GCCTCG/TTTTAA 1 -- us2k134Minor allele frequency- N:0.00NS EA NA WA CSA 3399
rs725487891,2
C,F--223914975(+) CTGCTT/CTTCCT 1 -- us2k13Minor allele frequency- C:0.00CSA WA 856
rs343484021,2
C,F--223914998(+) TGCTTC/TGTCCT 1 -- us2k17Minor allele frequency- T:0.01NA CSA WA 982
rs1468037061,2
--223915106(+) AACTTC/TAGCCT 1 -- us2k10--------
rs413110391,2
C,F--223915240(+) TGACCA/GATCTC 1 -- us2k14Minor allele frequency- G:0.05NS NA EA 560
rs1421459861,2
C--223915351(+) AGGCT-/TAGA  
        
TATAG
1 -- us2k10--------

HapMap Linkage Disequilibrium report for KCNE4 (223916532 - 224063117 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for KCNE4: --

Human Gene Mutation Database (HGMD): KCNE4
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing KCNE4
DNA2.0 Custom Variant and Variant Library Synthesis for KCNE4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607775    OMIM disorders: --

6 diseases for KCNE4:    About MalaCards
familial atrial fibrillation    quadriplegia    long qt syndrome    lymphoblastic leukemia
neuronitis    leukemia

1 disease from the University of Copenhagen DISEASES database for KCNE4:
Long QT syndrome

KCNE4 for disorders           About GeneDecksing

Genetic Association Database (GAD): KCNE4
Human Genome Epidemiology (HuGE) Navigator: KCNE4 (2 documents)

Export disorders for KCNE4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KCNE4 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with KCNE4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (2010)
  2. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1, 4 TreviA+o L.R....Relling M.V. (2009)
  3. The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population. (PubMed id 17016049)1, 4 Zeng Z....Pu J. (2007)
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  5. [The association of single nucleotide polymorphism of slow delayed rectifier K+ channel genes with atrial fibrillation in Han nationality Chinese] (PubMed id 16563243)1, 4 Zeng Z.Y....Gu D.F. (2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Novel gene hKCNE4 slows the activation of the KCNQ1 channel. (PubMed id 12670483)1, 3 Teng S....Hui R. (2003)
  8. KCNE4 is an inhibitory subunit to the KCNQ1 channel. (PubMed id 12096056)1, 2 Grunnet M.... Klaerke D.A. (2002)
  9. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PubMed id 10219239)1, 3 Abbott G.W.... Goldstein S.A.N. (1999)
  10. KCNE4 suppresses Kv1.3 currents by modulating traffic king, surface expression and channel gating. (PubMed id 19773357)1, 9 SolAc L....Felipe A. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23704 HGNC: 6244 AceView: KCNE4 Ensembl:ENSG00000152049 euGenes: HUgn23704
ECgene: KCNE4 H-InvDB: KCNE4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KCNE4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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